adherens junction organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.


homophilic cell adhesion via plasma membrane adhesion molecules

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.


sprouting angiogenesis

The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.


ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN


CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL


CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED


ETS TRANSLOCATION VARIANT 3-LIKE PROTEIN


ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF-LIKE


ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF


FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR


SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR


ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34A-RELATED


piRNA processing

A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.


PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE-LIKE PROTEIN 1


PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 GAMMA


PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 BETA


PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 BETA


PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 ALPHA


PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 GAMMA


PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA


lipid kinase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the phosphorylation of a simple or complex lipid.


LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 4


LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5


positive regulation of adenylate cyclase activity

Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.


regulation of adenylate cyclase activity

Any process that modulates the frequency, rate or extent of adenylate cyclase activity.


reproductive system development

The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.


reproductive structure development

The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.


male sex differentiation

The establishment of the sex of a male organism by physical differentiation.


sex differentiation

The establishment of the sex of an organism by physical differentiation.


male gonad development

The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.


regulation of endocytosis

Any process that modulates the frequency, rate or extent of endocytosis.


positive regulation of endocytosis

Any process that activates or increases the frequency, rate or extent of endocytosis.


regulation of receptor-mediated endocytosis

Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.


BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED


CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 40


HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN


CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 41


HAIRY AND ENHANCER OF SPLIT-RELATED PROTEIN HELT


HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2


HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1


Notch signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


circadian regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.


Notch signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1


defense response to fungus

Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.


defense response to Gram-negative bacterium

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.


SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 1


LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 2


STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 11


LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 4


STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 7


LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 1


LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 3


SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2


methylated histone binding

Binding to a histone in which a residue has been modified by methylation.


MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA


CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL


MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT BETA


CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL


mitochondrial protein processing

The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.


protein targeting to mitochondrion

The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.


protein processing involved in protein targeting to mitochondrion

The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments.


protein localization to mitochondrion

A process in which a protein is transported to, or maintained in, a location within the mitochondrion.


mitochondrial transport

Transport of substances into, out of or within a mitochondrion.


establishment of protein localization to mitochondrion

The directed movement of a protein to the mitochondrion or a part of the mitochondrion.


HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 SPECIFIC


EMC complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.


cysteine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1


NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2


NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3


negative regulation of canonical NF-kappaB signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 1


POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 2


POLYCYSTIC KIDNEY DISEASE 2-LIKE 1 PROTEIN


POLYCYSTIC KIDNEY DISEASE 2-LIKE 2 PROTEIN


POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 3


POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN


calcium-activated potassium channel activity

Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.


detection of mechanical stimulus

The series of events by which a mechanical stimulus is received and converted into a molecular signal.


response to mechanical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.


NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR


NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 3


ENDOPLASMIC RETICULUM MEMBRANE SENSOR NFE2L1


TRANSCRIPTION FACTOR NF-E2 45 KDA SUBUNIT


NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2


response to oxidative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


cellular response to chemical stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress.


cellular response to oxidative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.


osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.


THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2


THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2


KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL3


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 6-RELATED


KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL2-RELATED


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 2


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 4


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 2


KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL5A-RELATED


NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 3


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 1-RELATED


T-CELL-INTERACTING, ACTIVATING RECEPTOR ON MYELOID CELLS PROTEIN 1


KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL1-RELATED


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 4


LEUKOCYTE-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR 2


V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5


LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 5


LEUKOCYTE-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR 1


KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR-LIKE PROTEIN KIR3DX1-RELATED


KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL4


peptidyl-lysine acetylation

The acetylation of peptidyl-lysine.


internal peptidyl-lysine acetylation

The addition of an acetyl group to a non-terminal lysine residue in a protein.


protein acetylation

The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


internal protein amino acid acetylation

The addition of an acetyl group to a non-terminal amino acid in a protein.


39S RIBOSOMAL PROTEIN L11, MITOCHONDRIAL


cytosolic ribosome

A ribosome located in the cytosol.


cytosolic large ribosomal subunit

The large subunit of a ribosome located in the cytosol.


ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27


PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS


isomerase activity

Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.


protein disulfide isomerase activity

Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.


NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED


CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2


CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1


iron-sulfur cluster assembly

The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.


5HT2 type receptor mediated signaling pathway


5HT4 type receptor mediated signaling pathway


Histamine H2 receptor mediated signaling pathway


adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).


cellular response to organic cyclic compound

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.


regulation of muscle contraction

Any process that modulates the frequency, rate or extent of muscle contraction.


regulation of muscle system process

Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.


RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY


RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3


proteasome accessory complex

A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.


proteasome regulatory particle

A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.


proteasome regulatory particle, lid subcomplex

The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.


proteasome complex

A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.


endopeptidase complex

A protein complex which is capable of endopeptidase activity.


COP9 signalosome

A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.


C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8


protease binding

Binding to a protease or a peptidase.


acrosomal membrane

The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.


acrosomal vesicle

A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.


secretory granule membrane

The lipid bilayer surrounding a secretory granule.


secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.


plasma membrane fusion

The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.


fusion of sperm to egg plasma membrane involved in single fertilization

The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.


plasma membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.


membrane fusion

The membrane organization process that joins two lipid bilayers to form a single membrane.


COPII-coated ER to Golgi transport vesicle

A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).


DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE


DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED


glucosyltransferase activity

Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


protein N-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.


beta-catenin binding

Binding to a catenin beta subunit.


regulation of microtubule cytoskeleton organization

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.


extrinsic apoptotic signaling pathway in absence of ligand

The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.


negative regulation of canonical Wnt signaling pathway

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


negative regulation of Wnt signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.


VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1


regulation of calcium-mediated signaling

Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.


T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN


T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED


POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD21


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD12


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD19


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD16


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD11


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD15


BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD14


negative regulation of monoatomic ion transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of G protein-coupled receptor signaling pathway

Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.


NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY


neuropeptide hormone activity

The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.


feeding behavior

Behavior associated with the intake of food.


METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 1


METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 2-RELATED


METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 3-RELATED


DNA methylation-dependent heterochromatin formation

Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.


FLAGELLUM-ASSOCIATED COILED-COIL DOMAIN-CONTAINING PROTEIN 1


DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2


oligosaccharyltransferase complex

A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.


ATP-DEPENDENT RNA HELICASE DDX53-RELATED


ATP-DEPENDENT RNA HELICASE DDX43-RELATED


ATP-DEPENDENT RNA HELICASE DDX59-RELATED


ATP-DEPENDENT RNA HELICASE DDX41-RELATED


ATP-DEPENDENT RNA HELICASE DDX20-RELATED


ATP-DEPENDENT RNA HELICASE DDX17-RELATED


ATP-DEPENDENT RNA HELICASE DDX23-RELATED


SMN-Sm protein complex

A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.


SMN complex

A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.


poly(A)+ mRNA export from nucleus

The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.


spliceosomal snRNP assembly

The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.


U3 SMALL NUCLEOLAR RNA  U3 SNORNA  ASSOCIATED PROTEIN


negative regulation of MAPK cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.


negative regulation of stress-activated MAPK cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


regulation of p38MAPK cascade

Any process that modulates the frequency, rate or extent of p38MAPK cascade.


HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL


lipid oxidation

The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.


fatty acid catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.


fatty acid beta-oxidation

A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39


OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 1


COILED-COIL DOMAIN-CONTAINING PROTEIN 63


outer dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


cilium movement

The directed, self-propelled movement of a cilium.


axonemal dynein complex assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


POTE ANKYRIN DOMAIN FAMILY MEMBER B-RELATED


POTE ANKYRIN DOMAIN FAMILY MEMBER G-RELATED


TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER


EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-1


EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2


EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-1-LIKE


IMMUNOGLOBULIN SUPERFAMILY DCC SUBCLASS MEMBER 4


IMMUNOGLOBULIN SUPERFAMILY DCC SUBCLASS MEMBER 3


CELL ADHESION MOLECULE-RELATED_DOWN-REGULATED BY ONCOGENES


axonal growth cone

The migrating motile tip of a growing nerve cell axon.


COILED-COIL DOMAIN-CONTAINING PROTEIN 180


vitamin transport

The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


INTRAFLAGELLAR TRANSPORT PROTEIN 27 HOMOLOG


regulated exocytosis

A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.


positive regulation of secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.


positive regulation of exocytosis

Any process that activates or increases the frequency, rate or extent of exocytosis.


positive regulation of secretion by cell

Any process that activates or increases the frequency, rate or extent of secretion by cell.


pigmentation

The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.


neurotransmitter receptor transport to postsynaptic membrane

The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.


protein localization to synapse

Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


vesicle fusion

Fusion of the membrane of a transport vesicle with its target membrane.


organelle membrane fusion

The joining of two lipid bilayers to form a single organelle membrane.


phagolysosome assembly

The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.


organelle fusion

The creation of a single organelle from two or more organelles.


PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1


39S RIBOSOMAL PROTEIN L52, MITOCHONDRIAL


PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR


PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR 1


PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR 2


cytosolic small ribosomal subunit

The small subunit of a ribosome located in the cytosol.


small ribosomal subunit

The smaller of the two subunits of a ribosome.


negative regulation of Ras protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.


negative regulation of small GTPase mediated signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.


tissue morphogenesis

The process in which the anatomical structures of a tissue are generated and organized.


morphogenesis of an epithelium

The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.


ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER


ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 2


ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 1


SH3 domain binding

Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.


regulation of epidermal growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.


DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1


DNA exonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.


3'-5'-DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.


DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.


ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER


ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3


ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 2


ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1


intracellular lipid transport

The directed movement of lipids within cells.


long-chain fatty acid transport

The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


flavin adenine dinucleotide binding

Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.


oxidoreductase activity, acting on NAD(P)H

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


canonical inflammasome complex

A cytosolic protein complex that is capable of activating caspase-1.


cysteine-type endopeptidase activity involved in apoptotic process

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.


epidermis development

The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.


Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.


regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.


positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.


skin development

The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.


activation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.


epidermal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.


erythrocyte differentiation

The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.


intrinsic apoptotic signaling pathway in response to DNA damage

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.


intrinsic apoptotic signaling pathway

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).


positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.


CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3


CatSper complex

A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.


sperm motility

Any process involved in the controlled movement of a sperm cell.


cilium movement involved in cell motility

Movement of cilia mediated by motor proteins that contributes to the movement of a cell.


flagellated sperm motility

The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.


sperm capacitation

A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.


cilium or flagellum-dependent cell motility

Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.


cilium-dependent cell motility

Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY D MEMBER 1


DIFFERENTIALLY EXPRESSED IN FDCP 6 HOMOLOG


LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 1


EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 2


COLLAGEN AND CALCIUM-BINDING EGF DOMAIN-CONTAINING PROTEIN 1


LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 2


LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 3


LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 4


cell division site

The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.


cytoskeleton-dependent cytokinesis

A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.


cytokinesis

The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.


P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR


DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR  DMRT


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 2


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C2


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C1


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A1


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 3


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR B1


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 1


DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A2


tRNA processing

The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.


tRNA modification

The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.


SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED


ubiquitin-like protein ligase binding

Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase.


TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE


GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1


sugar-phosphatase activity

Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.


monosaccharide metabolic process

The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


glucose metabolic process

The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.


glucose 6-phosphate metabolic process

The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.


hexose biosynthetic process

The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.


hexose metabolic process

The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.


MAINTENANCE OF KILLER 16  MAK16  PROTEIN-RELATED


signaling adaptor activity

The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.


GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2


GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1


GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1


GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2


lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.


cyclase activity

Catalysis of a ring closure reaction.


phosphorus-oxygen lyase activity

Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


cGMP-mediated signaling

An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell.


cyclic-nucleotide-mediated signaling

An intracellular signaling cassette that starts with production or release of the cyclic nucleotide, and ends with the activation of downstream effectors that further transmit the signal within the cell.


cyclic nucleotide metabolic process

The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


cGMP biosynthetic process

The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.


WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3


WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4


antigen processing and presentation

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.


cell fate specification

The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.


mesoderm formation

The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.


mesoderm morphogenesis

The process in which the anatomical structures of the mesoderm are generated and organized.


mesoderm development

The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.


determination of left/right symmetry

The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.


left/right pattern formation

The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.


mononuclear cell migration

The movement of a mononuclear cell within or between different tissues and organs of the body.


lymphocyte migration

The movement of a lymphocyte within or between different tissues and organs of the body.


central nervous system neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.


cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.


regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


metaphase chromosome alignment

A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


establishment of chromosome localization

The directed movement of a chromosome to a specific location.


mitotic metaphase chromosome alignment

A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


chromosome localization

Any process in which a chromosome is transported to, or maintained in, a specific location.


microfilament motor activity

A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.


establishment or maintenance of epithelial cell apical/basal polarity

Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.


establishment or maintenance of apical/basal cell polarity

Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.


establishment or maintenance of bipolar cell polarity

Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns.


N-acyltransferase activity

Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.


IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED


NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3 LIGAND 1


IMMUNOGLOBULIN HEAVY CONSTANT ALPHA 1-RELATED


antibacterial humoral response

An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.


antimicrobial humoral response

An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.


PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 4


PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6


PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5


PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 7


serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


serine hydrolase activity

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


epidermal growth factor receptor signaling pathway

The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.


ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL


ATP SYNTHASE-COUPLING FACTOR 6, MITOCHONDRIAL


ATPase complex

A protein complex which is capable of ATPase activity.


mitochondrial proton-transporting ATP synthase complex

A proton-transporting ATP synthase complex found in the mitochondrial membrane.


proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.


inner mitochondrial membrane protein complex

Any protein complex that is part of the inner mitochondrial membrane.


proton-transporting ATP synthase complex

A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.


TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS


smoothened signaling pathway

The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.


APOLIPOPROTEIN L DOMAIN-CONTAINING PROTEIN 1


brush border

The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.


cluster of actin-based cell projections

A cell part consisting of multiple, closely packed actin-based cell projections.


antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).


metal cation:proton antiporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in).


regulation of intracellular pH

Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.


regulation of pH

Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.


regulation of cellular pH

Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.


SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL


RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1


oxidoreductase complex

Any protein complex that possesses oxidoreductase activity.


LYSOSOMAL ACID LIPASE_CHOLESTERYL ESTER HYDROLASE


DNA DC-DU-EDITING ENZYME APOBEC-3A-RELATED


hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2.


deaminase activity

Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R).


DNA modification

The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.


DNA demethylation

The removal of a methyl group from one or more nucleotides within an DNA molecule.


FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2


FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ETA


TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F


TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 7


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE T


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE U


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE DELTA


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE H


SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 4


SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 3


SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 1


efflux transmembrane transporter activity

Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.


IMMUNOGLOBULIN-LIKE AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1


chemokine receptor binding

Binding to a chemokine receptor.


positive regulation of mononuclear cell migration

Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.


positive regulation of leukocyte migration

Any process that activates or increases the frequency, rate, or extent of leukocyte migration.


positive regulation of leukocyte chemotaxis

Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.


MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL


long-chain fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE


PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE


response to reactive oxygen species

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


glutathione metabolic process

The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.


LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4


LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 3


ACETYLCHOLINESTERASE COLLAGENIC TAIL PEPTIDE


collagen trimer

A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.


low-density lipoprotein particle binding

Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.


protein-lipid complex binding

Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules.


lipoprotein particle binding

Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.


pattern recognition receptor activity

Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.


kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.


sensory perception of sound

The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.


sensory perception of mechanical stimulus

The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


cartilage development

The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


T CELL RECEPTOR ALPHA VARIABLE 23_DELTA VARIABLE 6


T CELL RECEPTOR ALPHA VARIABLE 29_DELTA VARIABLE 5


CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C


HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A


CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7B


DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A


CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A


DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C


ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA


CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B


CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A


CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA'


CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D


DUAL 3',5'-CYCLIC-AMP AND -GMP PHOSPHODIESTERASE 11A


HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8B


DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B


HIGH AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7A


HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A


ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA


ciliary membrane

The portion of the plasma membrane surrounding a cilium.


Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.


Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.


Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.


Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.


cAMP-mediated signaling

An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell.


oogenesis

The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.


regulation of cAMP-mediated signaling

Any process which modulates the frequency, rate or extent of cAMP-mediated signaling.


negative regulation of cAMP-mediated signaling

Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling.


purine ribonucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


purine-containing compound catabolic process

The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.


LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A-RELATED


LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B


PLATELET ENDOTHELIAL CELL ADHESION MOLECULE


HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA


LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-A-RELATED


HIGH AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR I-RELATED


RALBP1-ASSOCIATED EPS DOMAIN-CONTAINING PROTEIN 1


EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15


RALBP1-ASSOCIATED EPS DOMAIN-CONTAINING PROTEIN 2


EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15-LIKE 1


recycling endosome membrane

The lipid bilayer surrounding a recycling endosome.


endocytic vesicle

A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.


clathrin-dependent endocytosis

An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.


FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I


myofibril assembly

Formation of myofibrils, the repeating units of striated muscle.


striated muscle cell development

The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.


sarcomere organization

The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


cellular component assembly involved in morphogenesis

The cellular component assembly that is part of the initial shaping of the component during its developmental progression.


actomyosin structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.


GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR


negative regulation of neuron apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.


metalloexopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


metalloaminopeptidase activity

Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


aminopeptidase activity

Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.


peptide catabolic process

The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.


U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3


ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2


ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1


ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3


FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 1


FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 2


FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 3


TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25


transcription elongation factor complex

Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.


regulation of DNA-templated transcription elongation

Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


regulation of transcription elongation by RNA polymerase II

Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


nuclear receptor binding

Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.


RNA polymerase II-specific DNA-binding transcription factor binding

Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.


DNA-binding transcription factor binding

Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.


HOMEODOMAIN-INTERACTING PROTEIN KINASE 2


HOMEODOMAIN-INTERACTING PROTEIN KINASE 4


DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4


DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3


HOMEODOMAIN-INTERACTING PROTEIN KINASE 3


DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A


DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1B


DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2


HOMEODOMAIN-INTERACTING PROTEIN KINASE 1


intrinsic apoptotic signaling pathway by p53 class mediator

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.


intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.


signal transduction by p53 class mediator

An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein.


peptidyl-threonine phosphorylation

The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


IG-LIKE V-TYPE DOMAIN-CONTAINING PROTEIN FAM187A


DYNEIN HEAVY CHAIN DOMAIN-CONTAINING PROTEIN 1


microtubule associated complex

Any multimeric complex connected to a microtubule.


motile cilium

A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.


9+2 motile cilium

A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).


dynein complex

Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.


inner dynein arm

Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


axonemal dynein complex

A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


cytoplasmic microtubule

Any microtubule in the cytoplasm of a cell.


cytoplasmic dynein complex

Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.


outer dynein arm

Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


sperm flagellum

A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.


nuclear migration

The directed movement of the nucleus to a specific location within a cell.


cytoplasmic microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.


intraciliary retrograde transport

The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins.


RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1-RELATED


RNA BINDING MOTIF PROTEIN, X-LINKED-LIKE-1


regulation of mRNA splicing, via spliceosome

Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.


PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL


DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3


DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1


RNA polymerase III complex

RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.


Transcription regulation by bZIP transcription factor


5'-3' RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.


DNA-directed 5'-3' RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template.


RNA polymerase III activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase I activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 2


MITOCHONDRIAL AMIDOXIME-REDUCING COMPONENT 1


EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED


BMP-BINDING ENDOTHELIAL REGULATOR PROTEIN


RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR-LIKE PROTEIN


LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1


MYOSIN LIGHT CHAIN 1_3, SKELETAL MUSCLE ISOFORM


myosin complex

A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.


structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.


exocyst

A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.


Golgi to plasma membrane transport

The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.


WAS_WASL-INTERACTING PROTEIN FAMILY MEMBER 3


alpha-tubulin binding

Binding to the microtubule constituent protein alpha-tubulin.


Arp2/3 complex-mediated actin nucleation

The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.


regulation of apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.


regulation of intrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.


positive regulation of intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.


positive regulation of apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.


regulation of response to endoplasmic reticulum stress

Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress.


SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75A


MELANOMA ANTIGEN PREFERENTIALLY EXPRESSED IN TUMORS


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14B


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14


ENDOTHELIAL CELL-SELECTIVE ADHESION MOLECULE


acetylglucosaminyltransferase activity

Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.


UDP-galactosyltransferase activity

Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.


neural crest cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.


mesenchymal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.


mesenchyme development

The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.


stem cell development

The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.


neural crest cell development

The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.


stem cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


neural crest cell migration

The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.


positive regulation of axonogenesis

Any process that activates or increases the frequency, rate or extent of axonogenesis.


positive regulation of cell growth

Any process that activates or increases the frequency, rate, extent or direction of cell growth.


integrin-mediated signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


positive regulation of immune effector process

Any process that activates or increases the frequency, rate, or extent of an immune effector process.


positive regulation of growth

Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.


motor neuron axon guidance

The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.


bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.


post-mRNA release spliceosomal complex

A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac.


LEUCINE RICH REPEAT  IN FLII  INTERACTING PROTEIN


LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 2


LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 1


translesion synthesis

The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.


DNA biosynthetic process

The biosynthetic process resulting in the formation of DNA.


DNA synthesis involved in DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.


SH3 ADAPTER PROTEIN SPIN90  NCK INTERACTING PROTEIN WITH SH3 DOMAIN


Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.


Binding to phosphatidylinositol bisphosphate.


phosphatidylserine binding

Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.


response to radiation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.


DNA geometric change

The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.


hormone secretion

The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.


response to ionizing radiation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.


peptide transport

The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


peptide secretion

The controlled release of a peptide from a cell or a tissue.


response to estradiol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.


peptide hormone secretion

The regulated release of a peptide hormone from a cell.


regeneration

The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).


positive regulation of lipid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


hormone transport

The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


tissue regeneration

The regrowth of lost or destroyed tissues.


cellular response to reactive oxygen species

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


insulin secretion

The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.


response to interleukin-1

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.


cellular response to steroid hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.


DNA duplex unwinding

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.


DNA conformation change

A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.


response to steroid hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.


calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.


intracellular calcium ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.


mitochondrial calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.


cytokinetic process

A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).


WD REPEAT AND COILED-COIL-CONTAINING PROTEIN


H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHA


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHB


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHC


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHD


T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED


T CELL RECEPTOR ALPHA VARIABLE 36_DELTA VARIABLE 7


T CELL RECEPTOR ALPHA VARIABLE 20-RELATED


T CELL RECEPTOR ALPHA VARIABLE 1-1-RELATED


T CELL RECEPTOR ALPHA CHAIN MC.7.G5-RELATED


regulation of double-strand break repair

Any process that modulates the frequency, rate or extent of double-strand break repair.


regulation of DNA repair

Any process that modulates the frequency, rate or extent of DNA repair.


TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1


negative regulation of innate immune response

Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.


POTE ANKYRIN DOMAIN FAMILY MEMBER E-RELATED


Arp2/3 protein complex

A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.


actin cortical patch

An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.


Ino80 complex

A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.


INO80-type complex

A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair.


SWI/SNF superfamily-type complex

A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.


SWI/SNF complex

A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.


Swr1 complex

A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.


structural constituent of cytoskeleton

The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.


nucleosome binding

Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.


DBH-LIKE MONOOXYGENASE PROTEIN 2-RELATED


copper ion binding

Binding to a copper (Cu) ion.


biogenic amine metabolic process

The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.


catecholamine metabolic process

The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.


MAP_MICROTUBULE AFFINITY-REGULATING KINASE 4


PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1


HORMONALLY UP-REGULATED NEU TUMOR-ASSOCIATED KINASE


MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3


VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 2


VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 3


VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 1


SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN


PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL


FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1


amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.


membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a membrane.


REPLICATION STRESS RESPONSE REGULATOR SDE2


ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 3


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 6


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 1


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 10


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 4


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 7


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 9


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 2


TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 5


endoplasmic reticulum-Golgi intermediate compartment

A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.


vesicle targeting, to, from or within Golgi

The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.


vesicle targeting

The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.


vesicle budding from membrane

The evagination of a membrane, resulting in formation of a vesicle.


CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19


CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 16


CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 7


CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 3


CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1


CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 4


CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 20


V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE


INTERFERON-RELATED DEVELOPMENTAL REGULATOR 2


INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1


SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN


SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 8-RELATED


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 4


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 2


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 1


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 7-RELATED


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 6-RELATED


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 5


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 3


SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 9


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).


aromatic amino acid transmembrane transporter activity

Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.


basic amino acid transmembrane transporter activity

Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3.


proton transmembrane transport

The directed movement of a proton across a membrane.


basic amino acid transport

The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


CHROMOSOME TRANSMISSION FIDELITY FACTOR 18


CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG


ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5


ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2


INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1


negative regulation of apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.


negative regulation of intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.


mitochondrial fusion

Merging of two or more mitochondria within a cell to form a single compartment.


apoptotic mitochondrial changes

The morphological and physiological alterations undergone by mitochondria during apoptosis.


release of cytochrome c from mitochondria

The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.


ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL


ATP SYNTHASE SUBUNIT EPSILON-LIKE PROTEIN, MITOCHONDRIAL


ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL


proton channel activity

Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.


proton-transporting ATP synthase activity, rotational mechanism

Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out).


ATP biosynthetic process

The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


purine ribonucleoside triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.


purine nucleoside triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.


ribonucleoside triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.