tyrosine-based site-specific recombinase activity

Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site.


dTTP metabolic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate.


diphthine synthase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H+ + 3 S-adenosyl-L-homocysteine.


2,5-dioxopiperazine hydrolase activity

Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine.


8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.


cysteine lyase activity

Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide.


Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H+ = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4.


low-affinity phosphate transmembrane transporter activity

Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


N-glycan processing to lysosome

The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome.


malate dehydrogenase (NADP+) activity

Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+.


floral organ abscission

The controlled shedding of floral organs.


enucleation

The process in which nucleated precursor cells lose their nucleus.


Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP = (6E)-8-hydroxygeranial + NADPH + H+.


snRNA transcription

The synthesis of small nuclear RNA (snRNA) from a DNA template.


methionyl-tRNA aminoacylation

The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


B-1a B cell differentiation

The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.


positive stranded viral RNA replication

A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.


auditory receptor cell morphogenesis

Any process that alters the size or shape of an auditory receptor cell.


hypothalamus development

The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.


chrysobactin biosynthetic process

The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine).


Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate.


Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H+.


induction of platelet aggregation in another organism

Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism.


Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule.


cellular response to curcumin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus.


amylin receptor 3 signaling pathway

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The series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos.


epithelial cell proliferation involved in salivary gland morphogenesis

The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.


isopimaradienol hydroxylase activity

Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 = isopimaradiene-diol + NADP + H2O.


tartrate catabolic process

The chemical reactions and pathways resulting in the breakdown of tartrate.


regulation of hepatocyte growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.


primary alcohol metabolic process

The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.


paraxial mesoderm development

The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.


Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R.


cell wall biogenesis

A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.


aldarate transmembrane transporter activity

Enables the transfer of aldarate from one side of a membrane to the other.


protein kinase C deactivation

Any process resulting in the inhibition or termination of the activity of protein kinase C.


acetyl-coenzyme A:acetyl alcohol acetyltransferase activity

Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A.


Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP.


homogentisate 1,2-dioxygenase activity

Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.


negative regulation of mast cell activation

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.


leukocyte adhesion to vascular endothelial cell

The attachment of a leukocyte to vascular endothelial cell via adhesion molecules.


poly(glycerol phosphate) teichoic acid metabolic process

The chemical reactions and pathways involving poly(glycerol phosphate) teichoic acid.


intussusceptive angiogenesis

The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.


levanase activity

Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units.


dITP catabolic process

The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.


phosphocreatine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.


sorocarp stalk morphogenesis

The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.


sperm mitochondrial sheath assembly

The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.


positive regulation of vascular wound healing

Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


RNA localization to chromatin

A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.


ionotropic taste receptor activity

Enables the transmembrane transfer of an ion by a channel that opens when a soluble compound has been bound by the channel complex or one of its constituent parts.


mating-type factor pheromone receptor activity

Combining with a mating-type factor pheromone to initiate a change in cell activity.


mesonephric interstitial fibroblast development

The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure.


methanol metabolic process

The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent.


4-methoxybenzoate monooxygenase (O-demethylating) activity

Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O.


regulation of lipoprotein particle clearance

Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


positive regulation of endothelial cell migration

Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.


ureter development

The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


tRNA-derived regulatory ncRNA processing

A process leading to the generation of a functional small regulatory non-coding RNA derived from a tRNA.


protein localization to Cajal body

A process in which a protein is transported to, or maintained in, a location within a Cajal body.


membrane raft distribution

The process that establishes the spatial arrangement of membrane rafts within a cellular membrane.


negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching.


positive regulation of endocytic recycling

Any process that activates or increases the frequency, rate or extent of endocytic recycling.


nucleoside ribosyltransferase activity

Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1.


regulation of cargo loading into COPII-coated vesicle

Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle.


Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose.


arabinogalactan binding

Binding to arabinogalactan.


response to mitotic DNA integrity checkpoint signaling

A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling.


amylin receptor signaling pathway

A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


mycolic acid metabolic process

The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain.


regulation of toll-like receptor signaling pathway

Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.


maintenance of Golgi location

Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere.


globoside biosynthetic process via lactosylceramide

The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group.


berbamunine metabolic process

The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid.


planar cell polarity pathway involved in cardiac right atrium morphogenesis

The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium.


presynaptic modulation of chemical synaptic transmission

Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.


RNA-DNA hybrid ribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.


pole cell fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed.


detection of stimulus involved in sensory perception of pain

The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal.


N-acetylgalactosamine kinase activity

Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.


facial nerve development

The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.


methylamine metabolic process

The chemical reactions and pathways involving methylamine (CH3NH2).


detection of humidity stimulus involved in sensory perception

The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity.


septation initiation signaling

The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis.


glossopharyngeal nerve maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.


cell proliferation involved in imaginal disc-derived wing morphogenesis

The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis.


dorsal/ventral pattern formation, imaginal disc

The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed.


proximal convoluted tubule segment 1 cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney.


Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine.


morphine metabolic process

The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum.


ent-cassadiene-C2-hydroxylase activity

Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ = 2alpha-hydroxy-ent-cassadiene + NADP + H2O.


Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA.


male germ-line cyst formation

Formation of a group of interconnected cells derived from a single male gonial founder cell.


positive regulation of microglia differentiation

Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell.


N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity

Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine.


initiator methionyl aminopeptidase activity

Catalysis of the release of N-terminal initiator methionine from peptides.


precorrin-2 dehydrogenase activity

Catalysis of the reaction: NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin.


negative regulation of nerve growth factor receptor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor.


membrane protein proteolysis involved in retrograde protein transport, ER to cytosol

Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol.


metanephric descending thin limb development

The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle.


regulation of AV node cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


negative regulation of inner ear receptor cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation.


negative regulation of meiotic cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.


nerve growth factor processing

The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor.


histone H4 ubiquitin ligase activity

Catalysis of the transfer of ubiquitin to a histone H4 substrate.


Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate.


retinal ganglion cell axon guidance

The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


negative regulation of myoblast proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.


cardiac fibroblast cell differentiation

The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.


middle ear morphogenesis

The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).


negative regulation of ectoderm development

Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.


Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose.


RNA modification guide activity

Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue.


Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine.


dihydroxyfluorene dioxygenase activity

Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid.


mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication

A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication.


response to intra-S DNA damage checkpoint signaling

A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling.


peptidyl-arginine N5-methylation

The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine.


movement of group I intron

Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction.


ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase

A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide.


sinapate ester biosynthetic process

The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate.


neutrophil mediated cytotoxicity

The directed killing of a target cell by a neutrophil.


cranial ganglion development

The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.


positive regulation of stem cell differentiation

Any process that activates or increases the frequency, rate or extent of stem cell differentiation.


D-ribose biosynthetic process

The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose).


maintenance of shoot apical meristem identity

The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.


negative regulation of ureter smooth muscle cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation.


pteridine-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.


behavioral defense response

A behavioral response seeking to protect an organism from an a perceived external threat to that organism.


citrate catabolic process to diacetyl

The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP.


nephric duct formation

The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney.


branching involved in salivary gland morphogenesis

The process in which the branching structure of the salivary gland is generated and organized.


gluconate 2-dehydrogenase (acceptor) activity

Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor.


presynaptic active zone disassembly

The disaggregation of a presynaptic active zone into its constituent components.


meristem determinacy

The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate).


Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+.


head kidney morphogenesis

The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney.


GABA receptor activity

Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.


Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene.


embryonic neurocranium morphogenesis

The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.


regulation of trichome patterning

Any process that modulates the frequency, rate or extent of trichome patterning.


regulation of sporulation

Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in).


plasmacytoid dendritic cell activation involved in immune response

A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.


stabilization of membrane potential

The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


detection of mechanical stimulus involved in sensory perception of wind

The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal.


negative regulation of Schwann cell proliferation

Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


central nervous system neuron development

The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.


geraniol dehydrogenase activity

Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH.


iron-sulfur-molybdenum cofactor catabolic process

The chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor.


protein localization to non-growing cell tip

A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip.


left/right axis specification

The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).


glutamate catabolic process via 2-oxoglutarate

The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate.


pyrimidine dimer repair

The repair of UV-induced T-T, C-T and C-C dimers.


protein demethylation

The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.


protein-DNA covalent cross-linking activity

Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein.


symbiont-mediated perturbation of host microtubule cytoskeleton

The process in which an organism effects a change that impairs the structure or function of the host microtubule cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction.


regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


regulation of lung blood pressure

The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure.


21-deoxycortisol binding

Binding to 21-deoxycortisol.


male pigmentation

Establishment of a pattern of pigment in males.


specification of plant organ axis polarity

The process in which the polarity of a plant organ axis is specified.


execution phase of necroptosis

A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died.


detection of mechanical stimulus involved in sensory perception of sound

The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.


primary meristem tissue development

The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium.


3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity

Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O.


detection of nodal flow

The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.


RNA endonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.


response to electrical stimulus involved in regulation of muscle adaptation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.


osmoregulated periplasmic glucan biosynthetic process

The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan.


bacitracin A biosynthetic process

The chemical reactions and pathways resulting in the formation of bacitracin A.


response to G1 cell size control checkpoint signaling

A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling.


Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3.


cellular response to protozoan

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.


negative regulation of kainate selective glutamate receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway.


methane monooxygenase NADH activity

Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O.


fatty-acyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.


TRAIL-activated apoptotic signaling pathway

An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.


alveolar primary septum development

The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms.


hypochord development

The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta.


behavioral fear response

An acute behavioral change resulting from a perceived external threat.


arginyl-tRNA aminoacylation

The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


negative regulation of asymmetric cell division

Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.


L-rhamnose isomerase activity

Catalysis of the reaction: L-rhamnose = L-rhamnulose.


4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity

Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O.


muscle cell cellular homeostasis

The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.


aldehyde catabolic process

The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.


phosphocreatine metabolic process

The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle.


maintenance of protein complex location

Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away.


positive regulation of cell-matrix adhesion

Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.


symbiont-mediated suppression of host innate immune response

A process in which a symbiont inhibits or disrupts the normal execution of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.


5-carbamoylmethyl uridine residue modification

The chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA.


acetate ester metabolic process

The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.


dethiobiotin synthase activity

Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate.


versiconal hemiacetal acetate esterase activity

Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate.


cell migration involved in endocardial cushion formation

The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


arabinosyltransferase activity

Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor).


vascular endothelial cell response to oscillatory fluid shear stress

Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell.


enzyme-substrate adaptor activity

An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity.


Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein.


The chemical reactions and pathways involving (Z)-nonadeca-1,14-diene.


high-affinity L-ornithine transmembrane transporter activity

Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP.


equatorial microtubule organizing center assembly

The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center.


thylakoid membrane disassembly

The controlled breakdown of the thylakoid membrane in the context of a normal process.


extracellular polysaccharide metabolic process

The chemical reactions and pathways involving polysaccharides used in extracellular structures.


alcohol dehydrogenase (NADP+) activity

Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.


1,3-beta-glucanosyltransferase activity

Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation.


protein polyufmylation

Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain.


Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide.


negative regulation of sulfur utilization

Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization.


negative regulation of compound eye photoreceptor development

Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development.


torso signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H+.


positive regulation of myoblast proliferation

Any process that activates or increases the frequency, rate or extent of myoblast proliferation.


naringenin 3-dioxygenase activity

Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2.


positive regulation of developmental growth

Any process that activates, maintains or increases the rate of developmental growth.


gibberellin 20-oxidase activity

Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones.


homing of group II introns

Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure.


ethanolamine-containing compound metabolic process

The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it.


interleukin-3 receptor activity

Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


secretory granule maturation

Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling.


negative regulation of vascular associated smooth muscle cell migration

Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.


endosome membrane tubulation

A membrane tubulation process occurring in an endosome membrane.


Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose.


magnetoreception by sensory perception of mechanical stimulus

The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field.


regulation of cell projection size

A process that modulates the size of a cell projection.


histone H2AK13 ubiquitin ligase activity

Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue.


regulation of the force of heart contraction by chemical signal

The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


pituitary gland development

The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.


appressorium-mediated entry into host

Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction.


G protein-coupled glycine receptor activity

Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signaling.


cellular response to high density lipoprotein particle stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus.


xylose binding

Binding to the D- or L-enantiomer of xylose.


mitral valve formation

The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


regulation of inosine transport

Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


inductive mesenchymal to epithelial cell signaling

Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells.


negative regulation of sterol import

Any process that stops, prevents or reduces the frequency, rate or extent of sterol import.


exocrine pancreas development

The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.


accessory nerve formation

The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.


dextransucrase activity

Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1).


pyridoxal phosphate transmembrane transporter activity

Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.


regulation of hexasaccharide transport

Any process that modulates the frequency, rate or extent of hexasaccharide transport.


glutamatergic neuron differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron.


mono-ADP-D-ribose binding

Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment.


establishment of ommatidial planar polarity

The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.


dorsal vessel heart proper cell fate commitment

The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in).


abscisic acid metabolic process

The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid.


linolenate delta15 desaturase activity

Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor = 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor.


sebaceous gland placode formation

The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud.


induction of blood coagulation in another organism

Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.


regulation of integrin-mediated signaling pathway

Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway.


telomerase RNA localization

Any process in which telomerase RNA is transported to, or maintained in, a specific location.


cytoplasm organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.


cell surface receptor signaling pathway involved in heart development

The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time.


histone H3K9me2 methyltransferase activity

Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3.


leucoplast fission

The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes.


sulfate transmembrane transporter activity

Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.


response to retinoic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.


diarylpropane peroxidase activity

Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O.


mesenchymal stem cell differentiation involved in nephron morphogenesis

The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


regulation of systemic arterial blood pressure by baroreceptor feedback

The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control.


cytidine kinase activity

Catalysis of the reaction: ATP + cytidine = ADP + CMP.


alkanesulfonate catabolic process

The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.


copal-8-ol diphosphate(3-) metabolic process

The chemical reactions and pathways involving copal-8-ol diphosphate(3-).


Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol.


modulation by host of viral molecular function

A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected.


cell differentiation in spinal cord

The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.


contractile vacuole localization

The directed movement of the contractile vacuole to a specific location.


prostaglandin H2 endoperoxidase reductase activity

Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).


vitamin D3 25-hydroxylase activity

Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.


Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine.


melibiose binding

Binding to melibiose.


flavone biosynthetic process

The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone).


pectin binding

Binding to pectin.


positive regulation of glucose mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway.


protein to membrane docking

The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere.


arg-arg specific dibasic protein processing

Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein.


D-serine transmembrane transporter activity

Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid.


4-hydroxybenzoate 3-monooxygenase [NADH] activity

Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+.


colon epithelial cell migration

The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.


fructose-6-phosphate binding

Binding to fructose 6-phosphate.


glutamate catabolic process to aspartate

The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate.


pancreatic stellate cell proliferation

The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus.


mushroom body development

The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.


central canal development

The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord.


lipid droplet organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.


negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus.


inositol tetrakisphosphate 3-kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.


carbohydrate localization

Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.


sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process

The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-).


cellular response to aluminum ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.


induction of synaptic plasticity by chemical substance

The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require.


DNA damage response, signal transduction by p53 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.


positive regulation of skeletal muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.


malonyl-malonyl acyl carrier protein-condensing enzyme activity

Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] = 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein].


keratin filament binding

Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.


positive regulation of progesterone secretion

Any process that activates or increases the frequency, rate or extent of progesterone secretion.


Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.


endocardial cushion to mesenchymal transition involved in heart valve formation

A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.


interferon-delta production

The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


mannose biosynthetic process

The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose.


5-oxovalerate dehydrogenase activity

Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+.


limit dextrinase activity

Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan.


peptide glutaryltransferase activity

Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein].


positive regulation of saliva secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of saliva.


mannitol 2-dehydrogenase activity

Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH.


tryptophan catabolic process

The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


molting cycle, collagen and cuticulin-based cuticle

The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans.


protein-exporting ATPase activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.


Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome = H+ + cyclo-dopa 5-O-glucoside + UDP.


tRNA guanylyltransferase activity

Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.


Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate.


male germ-line cyst encapsulation

Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad.


negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


renal inner medulla development

The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney.


DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates

Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN.


negative regulation of cholangiocyte apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process.


2-phenylethylamine receptor activity

Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity.


face development

The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.


regulation of feeding behavior

Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.


regulation of platelet-derived growth factor receptor-beta signaling pathway

Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.


fluorene catabolic process

The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents.


complement component C3b receptor activity

Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


glycerol-3-phosphate oxidase activity

Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2.


negative regulation of cell migration in another organism

Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism.


myrtenal dehydrogenase activity

Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid.


generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


follicular dendritic cell activation

A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.


endosome fission

The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.


CAG codon-amino acid adaptor activity

A triplet codon-amino acid adaptor activity that recognizes a CAG codon.


cell-matrix adhesion involved in tangential migration using cell-cell interactions

The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex.


protein maturation by [4Fe-4S] cluster transfer

The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.


P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration

A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration.


protein localization to membrane raft

A process in which a protein is transported to, or maintained in, a location within a membrane raft.


heat shock-mediated polytene chromosome puffing

The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus.


negative regulation of cuticle pigmentation

Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism.


histone H3K56 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein.


galactitol biosynthetic process

The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose.


oxidoreductase activity, acting on CH or CH2 groups

Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


nerve development

The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.


response to G2 transition size control checkpoint signaling

A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling.


positive regulation of glucose import

Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.


diencephalon development

The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.


central tolerance induction to self antigen

Tolerance induction in the central lymphoid organs directed at self antigens.


microtubule severing ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.


S-linalool synthase activity

Catalysis of the reaction: geranyl diphosphate + H2O = (S)-linalool + diphosphate.


protocatechuate decarboxylase activity

Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2.


negative regulation of response to macrophage colony-stimulating factor

Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor.


peptidyl-selenocysteine modification

The modification of peptidyl-selenocysteine.


Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate.


negative regulation of defense response to bacterium

Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.


glomerular parietal epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


glucosylglycerol metabolic process

The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol.


regulation of insulin receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin receptor signaling.


Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments.


neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.


endothelin receptor activity

Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.


regulation of smooth muscle cell-matrix adhesion

Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion.


atrial cardiac muscle cell to AV node cell signaling

Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell.


negative regulation of chemokinesis

Any process that stops, prevents or reduces the frequency, rate or extent of chemokinesis.


plant gross anatomical part developmental process

Any developmental process whose specific outcome is the progression of a gross anatomical part of a plant from an initial immature state, to a later, more mature state.


oxazole or thiazole biosynthetic process

The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position.


cargo adaptor activity

Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.


seed coat development

The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure.


insemination

The introduction of semen or sperm into the genital tract of a female.


citrate CoA-transferase activity

Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.


immune response-inhibiting cell surface receptor signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of inhibiting an immune response.


indole phytoalexin metabolic process

The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response.


hopanoid biosynthetic process

The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus.


sexual sporulation

The formation of spores derived from the products of meiosis.


undecaprenyl-diphosphatase activity

Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.


regulation of response to calcium ion

Any process that modulates the frequency, rate or extent of response to calcium ion.


regulation of meiotic joint molecule formation

Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination.


6-deoxy-6-sulfofructose kinase activity

Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP.


neural retina development

The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix.


Z-phenylacetaldoxime metabolic process

The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants.


strigolactone metabolic process

The chemical reactions and pathways involving strigolactone.


chitosan binding

Binding to chitosan.


regulation of cell fate commitment

Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


positive regulation of synaptic plasticity

A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


developmental induction

A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).


positive regulation of artery morphogenesis

Any process that activates or increases the frequency, rate or extent of artery morphogenesis.


GTP biosynthetic process

The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.


D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity

Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate = D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate.


cellular response to cholecystokinin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus.


positive regulation of response to wounding

Any process that activates or increases the frequency, rate or extent of response to wounding.


interleukin-20 receptor activity

Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


positive regulation of behavioral fear response

Any process that activates or increases the frequency, rate or extent of behavioral fear response.


silicon efflux transmembrane transporter activity

Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane.


phosphorus utilization

A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism.


endoplasmic reticulum-plasma membrane tethering

The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.


wing disc morphogenesis

The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura.


beta-fructofuranosidase activity

Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside.


teichoic acid D-alanylation

The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid.


antigen processing and presentation initiated by receptor mediated uptake of antigen

Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor.


peptidyl-lysine 4-dioxygenase activity

Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2.


(S)-limonene 7-monooxygenase activity

Catalysis of the reaction: (4S)-limonene + H+ + NADPH + O2 = (4S)-perillyl alcohol + H2O + NADP+.


smoothened signaling pathway involved in lung development

The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development.


regulation of nitrogen cycle metabolic process

Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process.


sulfite reductase (ferredoxin) activity

Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin.


isocitrate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H.


glycyl-radical enzyme activating activity

Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM).


cross-receptor inhibition within G protein-coupled receptor heterodimer

Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit.


protein-arginine omega-N symmetric methyltransferase activity

Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.


thyroid hormone binding

Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.


negative regulation of epithelial tube formation

Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation.


blood vessel endothelial cell delamination

The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet.


semi-lunar valve development

The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure.


regulation of compound eye retinal cell apoptotic process

Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process.


Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds.


regulation of spontaneous neurotransmitter secretion

Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion.


ADP-specific glucokinase activity

Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate.


regulation of defense response to fungus

Any process that modulates the frequency, rate or extent of defense response to fungus.


Catalysis of the reaction: 2-methylpropanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].


cellular response to leukotriene B4

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus.


negative regulation of placenta blood vessel development

Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development.


negative regulation of flavonoid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids.


chlorophenol 4-monooxygenase activity

Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol.


floral meristem determinacy

The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate).


positive regulation of natural killer cell activation

Any process that activates or increases the frequency, rate or extent of natural killer cell activation.


peptidyl-methionine oxidation

The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone.


pentacyclic triterpenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.


iminodiacetate dehydrogenase activity

Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine.


Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.


negative regulation of calcium-mediated signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling.


cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity

Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 = ent-sandaracopimaradien-3beta-ol + NADP + H2O.


negative regulation of antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.


rhombomere boundary formation

The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


apolipoprotein A-I-mediated signaling pathway

The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


UTP binding

Binding to UTP, uridine 5'-triphosphate.


modification of postsynaptic actin cytoskeleton

Any process that modifies the structure of a postsynaptic actin cytoskeleton.


phthalate 3,4-dioxygenase activity

Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+.


allantoate deiminase activity

Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine.


positive regulation of lipopolysaccharide-mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol.


phototaxis

The directed movement of a motile cell or organism in response to light.


Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate.


midgut development

The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.


AMP-thymidine kinase activity

Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate.


indole-3-acetaldehyde reductase (NADPH) activity

Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH.


Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H+ + UDP.


isoleucyl-tRNA aminoacylation

The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


regulation of intermediate mesodermal cell fate determination

Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination.


regulation of gastric acid secretion

Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


short-chain fatty acyl-CoA dehydrogenase activity

Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.


glycerophosphodiester transmembrane transporter activity

Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.


The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule.


multicellular organism adhesion

The attachment of a multicellular organism to a substrate or other organism.


Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor.


indole acetic acid carboxyl methyltransferase activity

Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine.


encysted zoospore germination

The physiological, developmental and morphological changes that occur in an encysted zoospore, that germinates by developing a germ tube that may penetrate the host directly or indirectly through an appressorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction.


sulfinylpropanyl adenylate synthase

Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate.


regulation of ribonucleoprotein complex localization

Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization.


pronephric duct morphogenesis

The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.


Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A.


multivesicular body organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.


HNK-1 sulfotransferase activity

Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R).


endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


negative regulation of SREBP signaling pathway in response to increased oxygen levels

Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels.


production of molecular mediator involved in inflammatory response

The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.


regulation of keratinocyte apoptotic process

Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process.


theanine hydrolase activity

Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine.


negative regulation of ERBB4 signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway.


positive regulation of female pigmentation

Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females.


regulation of macrophage proliferation

Any process that modulates the frequency, rate or extent of macrophage proliferation.


learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time.


erythrocyte clearance

The selective elimination of erythrocytes from the body by autoregulatory mechanisms.


stomatal opening

The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange.


glucosinolate metabolic process

The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.


regulation of response to cell cycle checkpoint signaling

Any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling.


endoplasmic reticulum membrane biogenesis

The process in which an endoplasmic reticulum membrane is synthesized, aggregates, and bonds together.


positive regulation of response to G1 DNA damage checkpoint signaling

Any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling.


positive regulation of chromosome attachment to the nuclear envelope

Any process that activates or increases the frequency, rate or extent of the chromosome attachment to the nuclear envelope.


histone H3K36 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein.


soyasapogenol B UDP-glucosyl transferase activity

Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B = UDP(3-) + a soyasapogenol B monoglucoside.


positive regulation of defense response to oomycetes

Any process that activates or increases the frequency, rate or extent of defense response to oomycetes.


lectin-induced modified bacterial internalization

The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


regulation of transcytosis

Any process that modulates the frequency, rate or extent of transcytosis.


tetrahydrofolate biosynthetic process

The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.


negative regulation of renal albumin absorption

Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption.


regulation of calcium-dependent cell-cell adhesion

Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.


capsorubin synthase activity

Catalysis of the reaction: violaxanthin = capsorubin.


regulation of renal amino acid absorption

Any process that modulates the frequency, rate or extent of renal amino acid absorption.


regulation of post-embryonic development

Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.


planar cell polarity pathway involved in axon guidance

Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance.


cell adhesion involved in single-species biofilm formation

The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.


cellular modified histidine biosynthetic process

The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.


GDP-L-fucose metabolic process

The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate.


positive regulation of conidiophore development

Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.


hexulose-6-phosphate isomerase activity

Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate.


oligosaccharide transmembrane transporter activity

Enables the transfer of oligosaccharide from one side of a membrane to the other.


Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP.


response to vitamin B2

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus.


positive regulation of lipid catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.


intrachromosomal DNA recombination

The process of DNA recombination occurring within a single chromosome.


regulation of axial mesodermal cell fate specification

Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification.


polyphosphate kinase activity

Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).


phytoceramidase activity

Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine.


rRNA endonuclease activity

Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes.


spermine acetylation

The modification of spermine by addition of acetyl groups.


positive regulation of plasmacytoid dendritic cell antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.


digestive tract development

The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.


methanesulfonic acid metabolic process

The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide.