regulation of jasmonic acid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid.


regulation of tensidol A biosynthetic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that modulates the frequency, rate or extent of tensidol A biosynthetic process.


negative regulation of homocysteine metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.


regulation of proline catabolic process to glutamate

Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate.


positive regulation of penicillin catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.


positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase

Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase.


negative regulation of ferulate catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of ferulate catabolic process.


regulation of fatty acid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.


negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA

Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA.


negative regulation of acetate catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate.


positive regulation of methane biosynthetic process from formic acid

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from formic acid.


negative regulation of proline catabolic process to glutamate

Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate.


positive regulation of penicillin metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system.


positive regulation of ferulate catabolic process

Any process that activates or increases the frequency, rate or extent of ferulate catabolic process.


negative regulation of gamma-aminobutyric acid catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process.


regulation of cysteine metabolic process

Any process that modulates the frequency, rate or extent of cysteine metabolic process.


regulation of glutamine family amino acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.


positive regulation of cysteine metabolic process

Any process that activates or increases the frequency, rate or extent of cysteine metabolic process.


positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA

Any process that activates or increases the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA.


negative regulation of naphtho-gamma-pyrone biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process.


negative regulation of cellular glucuronidation

Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation.


regulation of endocrocin biosynthetic process

Any process that modulates the frequency, rate or extent of endocrocin biosynthetic process.


regulation of ubiquinone biosynthetic process

Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.


negative regulation of testosterone biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process.


negative regulation of selenocysteine metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine metabolic process.


negative regulation of tensidol B biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process.


regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent).


negative regulation of prostaglandin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


regulation of F-9775B biosynthetic process

Any process that modulates the frequency, rate or extent of F-9775B biosynthetic process.


negative regulation of initiation of acetate catabolic process by acetate

Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.


positive regulation of fatty acid beta-oxidation

Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.


negative regulation of indoleacetic acid biosynthetic process via tryptophan

Any process that stops, prevents or reduces the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan.


positive regulation of tryptophan metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


regulation of lysine biosynthetic process via aminoadipic acid

Any process that modulates the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid.


negative regulation of penicillin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of penicillin biosynthetic process.


negative regulation of ammonia assimilation cycle

Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle.


negative regulation of glutamate metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process.


positive regulation of abscisic acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid.


positive regulation of ubiquinone biosynthetic process

Any process that activates or increases the frequency, rate or extent of ubiquinone biosynthetic process.


negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid

Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid.


regulation of glyoxylate cycle

Any process that modulates the frequency, rate or extent of glyoxylate cycle.


positive regulation of progesterone biosynthetic process

Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process.


regulation of penicillin biosynthetic process

Any process that modulates the frequency, rate or extent of penicillin biosynthetic process.


regulation of methane biosynthetic process from 3-(methylthio)propionic acid

Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid.


regulation of acetate catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.


positive regulation of homocysteine metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.


negative regulation of homoserine biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of homoserine biosynthetic process.


positive regulation of fever generation by positive regulation of prostaglandin biosynthesis

Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


regulation of homoserine biosynthetic process

Any process that modulates the frequency, rate or extent of homoserine biosynthetic process.


regulation of aldosterone metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.


positive regulation of ecdysteroid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids.


positive regulation of acetate catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate.


negative regulation of gerfelin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of gerfelin biosynthetic process.


positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA

Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA.


negative regulation of ecdysteroid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids.


regulation of fumonisin biosynthetic process

Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process.


positive regulation of proline catabolic process to glutamate

Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate.


regulation of penicillin catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.


regulation of gibberellin biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins.


negative regulation of emericellin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process.


positive regulation of glyoxylate cycle

Any process that activates or increases the frequency, rate or extent of glyoxylate cycle.


regulation of retinoic acid biosynthetic process

Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process.


negative regulation of endocrocin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of endocrocin biosynthetic process.


regulation of emericellin biosynthetic process

Any process that modulates the frequency, rate or extent of emericellin biosynthetic process.


negative regulation of cysteine metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process.


positive regulation of cellular glucuronidation

Any process that activates or increases the frequency, rate or extent of cellular glucuronidation.


regulation of arginine biosynthetic process

Any process that modulates the frequency, rate or extent of arginine biosynthetic process.


positive regulation of retinoic acid biosynthetic process

Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process.


regulation of proline metabolic process

Any process that modulates the frequency, rate or extent of proline metabolic process.


negative regulation of asperthecin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of asperthecin biosynthetic process.


regulation of aldosterone biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


positive regulation of prostaglandin biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


negative regulation of kojic acid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process.


regulation of tensidol B biosynthetic process

Any process that modulates the frequency, rate or extent of tensidol B biosynthetic process.


negative regulation of neosartoricin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of neosartoricin biosynthetic process.


negative regulation of aldosterone biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


positive regulation of proline metabolic process

Any process that activates or increases the frequency, rate or extent of proline metabolic process.


regulation of fever generation by regulation of prostaglandin biosynthesis

Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


negative regulation of arginine catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process.


regulation of selenocysteine metabolic process

Any process that modulates the frequency, rate or extent of selenocysteine metabolic process.


positive regulation of gibberellin biosynthetic process

Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins.


positive regulation of glutamate metabolic process

Any process that activates or increases the frequency, rate or extent of glutamate metabolic process.


positive regulation of L-dopa biosynthetic process

Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process.


positive regulation of ammonia assimilation cycle

Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle.


positive regulation of fatty acid oxidation

Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.


positive regulation of homoserine biosynthetic process

Any process that activates or increases the frequency, rate or extent of homoserine biosynthetic process.


positive regulation of arginine biosynthetic process

Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process.


regulation of methane biosynthetic process from formic acid

Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid.


initiation of acetate catabolic process

The activation of the chemical reactions and pathways resulting in the breakdown of acetate.


regulation of cellular glucuronidation

Any process that modulates the frequency, rate or extent of cellular glucuronidation.


negative regulation of helvolic acid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of helvolic acid biosynthetic process.


negative regulation of butyryl-CoA catabolic process to butyrate

Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate.


regulation of abscisic acid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid.


regulation of 1-aminocyclopropane-1-carboxylate metabolic process

Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.


positive regulation of fatty acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


positive regulation of selenocysteine metabolic process

Any process that activates or increases the frequency, rate or extent of selenocysteine metabolic process.


negative regulation of polyketide biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process.


negative regulation of L-dopa biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process.


regulation of androst-4-ene-3,17-dione biosynthetic process

Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process.


positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.


regulation of ammonia assimilation cycle

Any process that modulates the frequency, rate or extent of ammonia assimilation cycle.


regulation of tetrapyrrole biosynthetic process from glutamate

Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate.


regulation of ecdysteroid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.


positive regulation of gamma-aminobutyric acid catabolic process

Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process.


negative regulation of progesterone biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process.


negative regulation of penicillin metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system.


positive regulation of naphtho-gamma-pyrone biosynthetic process

Any process that activates or increases the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process.


negative regulation of glyoxylate cycle

Any process that stops, prevents or reduces the frequency, rate or extent of glyoxylate cycle.


negative regulation of methane biosynthetic process from formic acid

Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from formic acid.


regulation of unsaturated fatty acid biosynthetic process

Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process.


negative regulation of 'de novo' NAD biosynthetic process from tryptophan

Any process that stops, prevents or reduces the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan.


negative regulation of proline biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of proline biosynthetic process.


regulation of xanthone-containing compound biosynthetic process

Any process that modulates the frequency, rate or extent of xanthone-containing compound biosynthetic process.


initiation of acetate catabolic process by acetate

The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.


positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation.


negative regulation of aldosterone metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.


negative regulation of F-9775A biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of F-9775A biosynthetic process.


negative regulation of F-9775B biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of F-9775B biosynthetic process.


regulation of kojic acid biosynthetic process

Any process that modulates the frequency, rate or extent of kojic acid biosynthetic process.


regulation of o-orsellinic acid biosynthetic process

Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process.


regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA

Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA.


negative regulation of bile acid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


regulation of penicillin metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system.


negative regulation of proline metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process.


negative regulation of ecdysteroid biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.


regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase

Any process that modulates the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase.


positive regulation of 'de novo' NAD biosynthetic process from tryptophan

Any process that activates or increases the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan.


positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid

Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid.


regulation of jasmonic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid.


regulation of leucine biosynthetic process

Any process that modulates the frequency, rate or extent of leucine biosynthetic process.


regulation of fatty acid beta-oxidation

Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.


negative regulation of progesterone biosynthesis involved in luteolysis

Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis.


positive regulation of xanthone-containing compound biosynthetic process

Any process that activates or increases the frequency, rate or extent of xanthone-containing compound biosynthetic process.


regulation of L-ascorbic acid biosynthetic process

Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process.


regulation of neosartoricin biosynthetic process

Any process that modulates the frequency, rate or extent of neosartoricin biosynthetic process.


regulation of homocysteine metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.


negative regulation of o-orsellinic acid biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process.


regulation of monodictyphenone biosynthetic process

Any process that modulates the frequency, rate or extent of monodictyphenone biosynthetic process.


positive regulation of tetrapyrrole biosynthetic process from glutamate

Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate.


regulation of fatty acid oxidation

Any process that modulates the frequency, rate or extent of fatty acid oxidation.


negative regulation of fatty acid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


positive regulation of butyryl-CoA catabolic process to butyrate

Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate.


positive regulation of citrulline biosynthetic process

Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process.


regulation of indoleacetic acid biosynthetic process via tryptophan

Any process that modulates the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan.


cobyrinic acid a,c-diamide synthase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide.


positive regulation of germ tube formation

Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction.


B800-820 antenna complex

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.


cell migration involved in coronary vasculogenesis

The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart.


cell migration involved in vasculogenesis

The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.


Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate.


positive regulation of calcium:sodium antiporter activity

Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity.


regulation of sodium ion transmembrane transport

Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport.


positive regulation of sodium ion transmembrane transport

Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport.


negative regulation of voltage-gated sodium channel activity

Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity.


regulation of sodium:proton antiporter activity

Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


regulation of sodium ion import across plasma membrane

Any process that modulates the frequency, rate or extent of sodium ion import across the plasma membrane.


positive regulation of sodium ion export across plasma membrane

Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.


negative regulation of sodium ion transmembrane transporter activity

Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.


positive regulation of sodium ion transmembrane transporter activity

Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.


negative regulation of sodium ion transmembrane transport

Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport.


regulation of P-type sodium:potassium-exchanging transporter activity

Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity.


regulation of calcium:sodium antiporter activity

Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity.


negative regulation of P-type sodium:potassium-exchanging transporter activity

Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity.


regulation of sodium ion export across plasma membrane

Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane.


negative regulation of sodium ion export across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane.


positive regulation of sodium:proton antiporter activity

Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


negative regulation of sodium ion import across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane.


negative regulation of sodium:proton antiporter activity

Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


regulation of voltage-gated sodium channel activity

Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity.


positive regulation of sodium ion import across plasma membrane

Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane.


negative regulation of calcium:sodium antiporter activity

Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity.


positive regulation of voltage-gated sodium channel activity

Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity.


regulation of kainate selective glutamate receptor activity

Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity.


tRNA-guanine transglycosylation

The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine.


cysteine sulfinate desulfinase activity

Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite.


mast cell apoptotic process

Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


cAMP response element binding

Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.


nitric oxide storage

The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.


His-Purkinje system development

The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.


ventricular cardiac muscle tissue development

The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.


bundle of His development

The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.


Purkinje myocyte development

The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.


negative regulation of cellotriose catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose catabolic process.


inositol tetrakisphosphate 1-kinase activity

Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.


phospholipase C-activating tachykinin receptor signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by tachykinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


phospholipase C-activating endothelin receptor signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


phospholipase C-activating serotonin receptor signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


phospholipase C-activating adrenergic receptor signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


phospholipase C-activating dopamine receptor signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


phospholipase C-activating angiotensin-activated signaling pathway involved in heart process

An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.


phospholipase C-activating angiotensin-activated signaling pathway

A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


phospholipase C-activating rhodopsin mediated signaling pathway

A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by a rhodopsin molecule being activated by a photon, and ending with the regulation of a downstream cellular process, e.g. transcription.


MIS12/MIND type complex

A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.


gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling

A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


gap junction channel activity

A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.


gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling

A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


gap junction channel activity involved in cardiac conduction electrical coupling

A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling

A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling

A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling

A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


gap junction channel activity involved in cell communication by electrical coupling

Any gap junction channel activity that is involved in cell communication by electrical coupling.


pyrimidine nucleobase fermentation

The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP.


interleukin-4 binding

Binding to interleukin-4.


FACT complex assembly

The aggregation, arrangement and bonding together of a set of components to form a FACT complex.


anatomical entity

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.


acellular anatomical structure

Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.


multi cell part structure

A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.


material anatomical entity

Anatomical entity that has mass.


anatomical structure

Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.


negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process.


Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O = H+ + 2-(7'-methylthio)heptylmalate + coenzyme A.


detection of low humidity stimulus involved in sensory perception

The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity.


negative regulation of 18-methylnonadec-1-ene metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process.


negative regulation of olefin metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of olefin metabolic process.


negative regulation of 18-methylnonadec-1-ene biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process.


negative regulation of nonadec-1-ene metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene metabolic process.


negative regulation of ethylene biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process.


negative regulation of octadecene biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of octadecene biosynthetic process.


negative regulation of 17-methylnonadec-1-ene biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process.


negative regulation of octadecene metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process.


negative regulation of nonadec-1-ene biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene biosynthetic process.


negative regulation of (Z)-nonadeca-1,14-diene metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process.


negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process.


negative regulation of isoprene metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of isoprene metabolic process.


negative regulation of olefin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of olefin biosynthetic process.


negative regulation of 17-methylnonadec-1-ene metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process.


cyanelle outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope.


plant-type hypersensitive response

The rapid, localized death of plant cells in response to invasion by a pathogen.


symbiont-induced defense-related programmed cell death

Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules.


replication compartment

Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously.


nuclear viral factory

A viral factory located in the nucleus of a host cell.


peristromal region viral factory

A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses.


virogenic stroma

A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled.


positive regulation of timing of anagen

Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.


positive regulation of hair follicle maturation

Any process that activates or increases the frequency, rate or extent of hair follicle maturation.


positive regulation of timing of exogen

Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle.


positive regulation of timing of catagen

Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


cellular response to tumor cell

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.


respiratory burst involved in defense response

A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


respiratory burst after phagocytosis

A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.


respiratory burst involved in inflammatory response

A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.


interleukin-6 binding

Binding to interleukin-6.


positive regulation of early stripe melanocyte differentiation

Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation.


positive regulation of melanocyte differentiation

Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.


positive regulation of late stripe melanocyte differentiation

Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation.


heterotrimeric G-protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex.


alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex

A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2.


Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor.


negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


peptide antigen binding

Binding to an antigen peptide.


exogenous lipid antigen binding

Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).


protein antigen binding

Binding to a protein antigen.


lipid antigen binding

Binding to a lipid antigen.


endogenous lipid antigen binding

Binding to an endogenous cellular lipid antigen.


rhizobactin 1021 biosynthetic process

The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.


tertiary alcohol metabolic process

The chemical reactions and pathways involving tertiary alcohol.


rhizobactin 1021 metabolic process

The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.


cis-abienol biosynthetic process

The chemical reactions and pathways resulting in the formation of cis-abienol.


tetracenomycin C catabolic process

The chemical reactions and pathways resulting in the breakdown of tetracenomycin C.


cortisol metabolic process

The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


tetracenomycin C metabolic process

The chemical reactions and pathways involving tetracenomycin C.


neosartoricin biosynthetic process

The chemical reactions and pathways resulting in the formation of neosartoricin.


paxilline biosynthetic process

The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels.


rhodopsin catabolic process

The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas.


asperfuranone catabolic process

The chemical reactions and pathways resulting in the breakdown of asperfuranone.


cortisol biosynthetic process

The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


viridicatumtoxin biosynthetic process

The chemical reactions and pathways resulting in the formation of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system.


neosartoricin metabolic process

The chemical reactions and pathways involving neosartoricin.


asperfuranone biosynthetic process

The chemical reactions and pathways resulting in the formation of asperfuranone.


tetracenomycin C biosynthetic process

The chemical reactions and pathways resulting in the formation of tetracenomycin C.


tertiary alcohol biosynthetic process

The chemical reactions and pathways resulting in the formation of tertiary alcohol.


cis-abienol metabolic process

The chemical reactions and pathways involving cis-abienol.


cis-abienol catabolic process

The chemical reactions and pathways resulting in the breakdown of cis-abienol.


neosartoricin catabolic process

The chemical reactions and pathways resulting in the breakdown of neosartoricin.


paraherquonin biosynthetic process

The chemical reactions and pathways resulting in the formation of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture.


asperfuranone metabolic process

The chemical reactions and pathways involving asperfuranone.


Hub1 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond.


sulfopyruvate decarboxylase activity

Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde.


optic nerve formation

The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR).


negative regulation of mast cell proliferation

Any process that stops, prevents or reduces the rate or extent of mast cell proliferation.


embryonic heart tube dorsal/ventral pattern formation

The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis.


negative regulation of p38MAPK cascade

Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.


lateral line nerve development

The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


posterior lateral line nerve development

The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


anterior lateral line nerve development

The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.


trabecula formation

The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


heart trabecula formation

The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.


spleen trabecula formation

The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.


liver trabecula formation

The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod.


bone trabecula formation

The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.


guanylate cyclase inhibitor activity

Binds to and stops, prevents or reduces the activity of guanylate cyclase.


acetylglutamate kinase regulator activity

Binds to and modulates the activity of acetylglutamate kinase.


channel activator activity

Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


gonadotropin hormone-releasing hormone activity

The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.


inositol phosphoceramide synthase regulator activity

Binds to and modulates the activity of inositol phosphoceramide synthase.


histone methyltransferase inhibitor activity

Binds to and stops, prevents or reduces the activity of a histone methyltransferase.


acetyltransferase activator activity

Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.


ornithine decarboxylase activator activity

Binds to and increases ornithine decarboxylase activity.


cytoskeletal motor inhibitor activity

Binds to and stops, prevents, or reduces the activity of a motor protein.


opioid peptide activity

Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.


cyclin-dependent protein serine/threonine kinase regulator activity

Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.


transmembrane receptor protein tyrosine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase.


chemoattractant activity involved in axon guidance

Any chemoattractant activity that is involved in axon guidance.


RNA polymerase inhibitor activity

Binds to and stops, prevents or reduces the activity of RNA polymerase.


eclosion hormone activity

The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis.


phosphatidylcholine-sterol O-acyltransferase activator activity

Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase.


pseudophosphatase activity

Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.


cyclin-dependent protein kinase activating kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).


histone deacetylase inhibitor activity

Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes.


phosphatidylinositol 3-kinase activator activity

Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K).


peptidase activator activity involved in apoptotic process

Binds to and increases the activity of a peptidase that is involved in the apoptotic process.


peroxidase inhibitor activity

Binds to and stops, prevents or reduces the activity of peroxidase.


urease activator activity

Increases the activity of urease by promoting the incorporation of nickel into the active site.


phosphatidylinositol 3-kinase inhibitor activity

Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K).


morphogen activity

Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.


melanin-concentrating hormone activity

The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.


digestive hormone activity

The action characteristic of a hormone that takes part in the digestion process.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


adenylate cyclase regulator activity

Binds to and modulates the activity of adenylate cyclase.


Binds to and increases the activity of an endodeoxyribonuclease.


tyrosine 3-monooxygenase activator activity

Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase).


mating pheromone activity

The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.


tryptophan hydroxylase activator activity

Increases the activity of the enzyme tryptophase hydroxylase.


phospholipase inhibitor activity

Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.


phosphatase activator activity

Binds to and increases the activity of a phosphatase.


glutamate-cysteine ligase regulator activity

Binds to and modulates the activity of glutamate-cysteine ligase.


ligase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ligase.


melanocyte-stimulating hormone activity

The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates.


aldehyde dehydrogenase (NAD+) inhibitor activity

Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+).


[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity

Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase.


transporter inhibitor activity

Binds to and stops, prevents, or reduces the activity of a transporter.


calcium sensitive guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.


myoinhibitory hormone activity

The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction.


telomerase inhibitor activity

Binds to and stops, prevents or reduces the activity of telomerase.


protein kinase C inhibitor activity

Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.


sodium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a sodium channel.


neurohypophyseal hormone activity

The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin.


calcium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a calcium channel.


cyclase regulator activity

Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction.


phospholipase D activator activity

Binds to and increases the activity of the enzyme phospholipase D.


ubiquitin-protein transferase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase.


ATPase inhibitor activity

Binds to and stops, prevents or reduces an ATP hydrolysis activity.


cAMP-dependent protein kinase regulator activity

Modulation of the activity of the enzyme cAMP-dependent protein kinase.


polynucleotide adenylyltransferase activator activity

Increases the activity of the enzyme polynucleotide adenylyltransferase.


ornithine decarboxylase inhibitor activity

Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.


acetylcholine receptor inhibitor activity

Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.


cysteine-type endopeptidase activator activity involved in apoptotic process

Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.


phospholipase D inhibitor activity

Binds to and stops, prevents or reduces the activity of phospholipase D.


receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.


growth hormone-releasing hormone activity

The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland.


prothoracicotrophic hormone activity

The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects.


follicle-stimulating hormone activity

The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.


methionine adenosyltransferase regulator activity

Binds to and modulates the activity of methionine adenosyltransferase.


protein phosphatase activator activity

Binds to and increases the activity of a protein phosphatase.


lipoprotein lipase activator activity

Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.


cyclin-dependent protein kinase activating kinase regulator activity

Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase.


deubiquitinase activator activity

Binds to and increases the activity of a deubiquitinase.


calcium-dependent protein serine/threonine phosphatase regulator activity

Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.


pituitary adenylate cyclase activating polypeptide activity

The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.


phospholipase activator activity

Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.


adenylate cyclase inhibitor activity

Binds to and decreases the activity of adenylate cyclase.


cysteine-type endopeptidase activator activity

Binds to and increases the activity of a cysteine-type endopeptidase.


endopeptidase activator activity

Binds to and increases the activity of an endopeptidase.


ubiquitin ligase activator activity

Binds to and increases the activity of a ubiquitin ligase.


iron ion transmembrane transporter inhibitor activity

Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter.


cyclin-dependent protein serine/threonine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.


repressor of RNA polymerase inhibitor activity

Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor.


GTPase inhibitor activity

Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.


chemokine activity

The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


guanyl nucleotide exchange factor inhibitor activity

Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.


competence pheromone activity

A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence.


histone deacetylase regulator activity

Binds to and modulates the activity of histone deacetylase.


death receptor agonist activity

Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.


protein tyrosine kinase activator activity

Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.


guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase.


calcium channel regulator activity

Modulates the activity of a calcium channel.


DNA strand exchange activator activity

Binds to and increases a DNA strand exchange activity.


miRNA inhibitor activity via base-pairing

Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs).


L-dopa decarboxylase activator activity

Interacts with and increases L-dopa decarboxylase activity.


Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity.


growth hormone activity

The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth.


ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity

Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.


ribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of ribonuclease.


UTP:glucose-1-phosphate uridylyltransferase regulator activity

Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase.


receptor signaling protein tyrosine kinase activator activity

Binds to and increases the activity of a receptor signaling protein tyrosine kinase.


pathogen-derived receptor ligand activity

The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.


ubiquitin-protein transferase activator activity

Binds to and increases the activity of a ubiquitin-protein transferase.


actin severing activator activity

Binds to and increases the activity of a actin severing protein.


receptor antagonist activity

The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.


cyclic nucleotide phosphodiesterase activator activity

Binds to and increases the activity of cyclic nucleotide phosphodiesterase.


cyclin-dependent protein serine/threonine kinase activator activity

Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.


calcium-dependent protein kinase regulator activity

Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner.


transcription regulator activator activity

A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification.


lipase inhibitor activity

Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


acetylcholine receptor activator activity

Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.


endoribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of endoribonuclease.


RNA helicase inhibitor activity

Binds to and stops, prevents or reduces the activity of an RNA helicase.


potassium channel activator activity involved in G protein-coupled receptor signaling pathway

Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.


ion channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an ion channel.


ornithine carbamoyltransferase inhibitor activity

Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase.


pectinesterase inhibitor activity

Binds to and stops, prevents or reduces the activity of pectinesterase.


guanylate cyclase regulator activity

Modulates the activity of guanylate cyclase.


protein tyrosine phosphatase activator activity

Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.


interleukin-1 receptor antagonist activity

Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.


eukaryotic elongation factor-2 kinase regulator activity

Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase.


ion channel regulator activity

Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


myosin phosphatase regulator activity

Binds to and modulates of the activity of myosin phosphatase.


exoribonuclease activator activity

Binds to and increases the activity of an exoribonuclease.


ecdysis-triggering hormone activity

The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.


GTP cyclohydrolase I regulator activity

Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.


methyltransferase regulator activity

Binds to and modulates the activity of a methyltransferase.


tRNA methyltransferase activator activity

Binds to and increases the activity of a methyltransferase.


cysteine-type endopeptidase regulator activity involved in apoptotic process

Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.


mRNA phosphatase activator activity

Binds to and increases the activity of mRNA phosphatase.


neurotransmitter receptor regulator activity

A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing.


signaling receptor inhibitor activity

Binds to and modulates the activity of a signaling receptor.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity

Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity

Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase.


adenyl-nucleotide exchange factor activity

Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.


potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a potassium channel.


interleukin-1 type II receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type II receptors.


peptidyl-dipeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain.


Rho GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.


metalloendopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.


phosphatidylinositol 3-kinase regulator activity

Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.


sodium channel regulator activity

Binds to and modulates the activity of a sodium channel.


ATPase regulator activity

Binds to and modulates the activity of an ATP hydrolysis activity.


nitric-oxide synthase inhibitor activity

Binds to and stops, prevents or reduces the activity of nitric oxide synthase.


transcription regulator inhibitor activity

A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.


receptor ligand inhibitor activity

Binds to and decreases the activity of the ligand of a signaling receptor.


interleukin-1 type I receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 type I receptors.


histone acetyltransferase regulator activity

Binds to and modulates the activity of histone acetyltransferase.


small conductance calcium-activated potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel.


RNA lariat debranching enzyme activator activity

Binds to and increases the activity of an RNA lariat debranching enzyme.


1-phosphatidylinositol 4-kinase activator activity

Binds to and increases the activity of 1-phosphatidylinositol 4-kinase.


phospholipase A2 activator activity

Binds to and increases the activity of the enzyme phospholipase A2.


tRNA ligase activator activity

Binds to and increases the activity of a tRNA ligase.


acetolactate synthase regulator activity

Binds to and modulates the activity of acetolactate synthase.


calcium-dependent cysteine-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner.


eukaryotic elongation factor-2 kinase activator activity

Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase.


Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.


sphingomyelin phosphodiesterase activator activity

Binds to and increases the activity of the enzyme sphingomyelin phosphodiesterase.


activin receptor antagonist activity

Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.


transporter activator activity

Binds to and increases the activity of a transporter.


sphingolipid activator protein activity

Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.


transporter regulator activity

Binds to and modulates the activity of a transporter.


outward rectifier potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.


dolichol-phosphate-mannose synthase regulator activity

Binds to and modulates the activity of dolichol-phosphate-mannose synthase.


ion channel regulator activity involved in G protein-coupled receptor signaling pathway

Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling.


nuclease inhibitor activity

Binds to and modulates the activity of a nuclease.


polygalacturonase inhibitor activity

Binds to and stops, prevents or reduces the activity of polygalacturonase.


pheromone activity

The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant.


phosphorylase kinase regulator activity

Modulation of the activity of the enzyme phosphorylase kinase.


ribonucleoside-diphosphate reductase inhibitor activity

Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase.


transmembrane receptor protein tyrosine kinase activator activity

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.


aspartic-type endopeptidase inhibitor activity

Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases.


recombinase activator activity

Binds to and increases the activity of a recombinase.


DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity

Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.


inward rectifier potassium channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.


cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.


guanyl nucleotide exchange factor activator activity

Binds to and increases the activity of a guanyl nucleotide exchange factor.


chemokine receptor antagonist activity

Interacts with chemokine receptors to reduce the action of a chemokine.


thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


chemoattractant activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.


DNA polymerase processivity factor activity

An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.


SUMO ligase regulator activity

Binds to and modulates the activity of a SUMO ligase.


fibroblast growth factor receptor antagonist activity

Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.


The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.


guiding stereospecific synthesis activity

The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis.


cytoskeletal motor activator activity

Binds to and increases the activity of a motor protein.


DNA strand exchange inhibitor activity

Binds to and stops, prevents or reduces a DNA strand exchange activity.


chloride channel regulator activity

Binds to and modulates the activity of a chloride channel.


kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a kinase.


cAMP-dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.


nitric-oxide synthase regulator activity

Binds to and modulates the activity of nitric oxide synthase.


alpha-amylase inhibitor activity

Binds to and stops, prevents or reduces the activity of alpha-amylase.


myostimulatory hormone activity

The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction.


cyclase inhibitor activity

Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction.


cytoskeletal motor regulator activity

Binds to and modulates the activity of a motor protein.


G protein activity

A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).


ornithine decarboxylase regulator activity

Binds to and modulates the activity of the enzyme ornithine decarboxylase.


ubiquitin ligase inhibitor activity

Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.


ecdysiostatic hormone activity

The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion.


channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a channel.


lipase activator activity

Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


adenylate cyclase activator activity

Binds to and increases the activity of adenylate cyclase.


cyclase activator activity

Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction.


protein serine/threonine kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.


protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a protein tyrosine kinase.


calcium-dependent protein kinase inhibitor activity

Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase.


phospholipase A2 inhibitor activity

Binds to and stops, prevents or reduces the activity of phospholipase A2.


ligase regulator activity

Binds to and modulates the activity of a ligase.


superoxide-generating NADPH oxidase activator activity

Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase.


diuretic hormone activity

The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.


neuropeptide activity

The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron.


lysozyme inhibitor activity

Binds to and stops, prevents or reduces the activity of lysozyme.


deoxyribonuclease inhibitor activity

Binds to and stops, prevents or reduces the activity of deoxyribonuclease.


guanyl-nucleotide exchange factor adaptor activity

The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.


dUTP pyrophosphatase inhibitor activity

Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase.


Rab GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.


chemorepellent activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.


ubiquitin-protein transferase regulator activity

Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.


potassium channel activator activity

Binds to and increases the activity of a potassium channel, resulting in its opening.


chloride channel inhibitor activity

Binds to and stops, prevents, or reduces the activity of a chloride channel.


sulfopyruvate decarboxylase complex

A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis.


2-butanone oxidase activity

Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate.


negative regulation of photomorphogenesis

Any process that stops, reduces or prevents photomorphogenesis.


terminal web assembly

The aggregation, arrangement and bonding together of a set of components to form a terminal web.


positive regulation of brain-derived neurotrophic factor-activated receptor activity

Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


positive regulation of protein-pyridoxal-5-phosphate linkage

Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


positive regulation of kinin cascade

Any process that activates or increases the frequency, rate, or extent of the kinin cascade.


positive regulation of serine-type peptidase activity

Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity.


positive regulation of cap-dependent translational initiation

Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation.


regulation of hepatocyte growth factor production

Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production.


positive regulation of CD86 production

Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.


positive regulation of protein autoubiquitination

Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.


positive regulation of protein kinase C activity

Any process that activates or increases the frequency, rate or extent of protein kinase C activity.


regulation of translation at synapse

Any process that regulates translation occurring at the synapse.


regulation of glucosylceramide catabolic process

Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process.


positive regulation of proteolysis associated with antigen processing and presentation

Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of CD24 production

Any process that modulates the frequency, rate or extent of CD24 biosynthetic process.


positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division

Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division.


negative regulation of peptidyl-tyrosine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


negative regulation of hepatocyte growth factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production.


negative regulation of protein polyubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination.


regulation of gliotoxin biosynthetic process

Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process.


positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


positive regulation of aspartic-type peptidase activity

Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity.


negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.


regulation of amyloid-beta formation

Any process that modulates the frequency, rate or extent of amyloid-beta formation.


positive regulation of myosin light chain kinase activity

Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.


negative regulation of protein K63-linked ubiquitination

Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination.


positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity

Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate.


negative regulation of ubiquitin-protein transferase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.


negative regulation of peptidyl-cysteine S-nitrosylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


positive regulation of tubulin deacetylation

Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


inhibition of cysteine-type endopeptidase activity involved in apoptotic process

Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process.


positive regulation of protein histidine kinase activity

Any process that increases the frequency, rate or extent of protein histidine kinase activity.


positive regulation of protein catabolic process in the vacuole

Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole.


negative regulation of cyclin-dependent protein kinase activity

Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity.