proton motive force-driven ATP synthesis

The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.


nucleoside triphosphate biosynthetic process

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.


KERATIN, TYPE II CYTOSKELETAL 6B-RELATED


KERATIN, TYPE II CYTOSKELETAL 2 EPIDERMAL


intermediate filament

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.


intermediate filament cytoskeleton

Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.


keratin filament

A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.


intermediate filament organization

Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.


intermediate filament cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.


intermediate filament-based process

Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.


Golgi to plasma membrane protein transport

The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.


CHORIOGONADOTROPIN SUBUNIT BETA 3-RELATED


CHORIOGONADOTROPIN SUBUNIT BETA VARIANT 2


Thyrotropin-releasing hormone receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent


Seh1-associated complex

A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.


negative regulation of TORC1 signaling

Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.


nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.


nuclear inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.


oxidoreductase activity, acting on the CH-CH group of donors

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.


cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


secondary alcohol biosynthetic process

The chemical reactions and pathways resulting in the formation of secondary alcohol.


sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


phytosteroid metabolic process

The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi.


SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL


mitochondrial intermembrane space

The region between the inner and outer lipid bilayers of the mitochondrial envelope.


dicarboxylic acid metabolic process

The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).


mitochondrial respiratory chain complex II assembly

The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane.


LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED


LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG


KDEL  LYS-ASP-GLU-LEU  CONTAINING - RELATED


IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2


IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1


BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2


BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 3


BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1


IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 3


GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1


ruffle membrane

The portion of the plasma membrane surrounding a ruffle.


V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10


V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2


ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4


ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5


ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 7


SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA


SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3


SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1


POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 2


POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1


SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-4


SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-2


P-type ion transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.


regulation of intracellular protein transport

Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.


bioactive lipid receptor activity

Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.


phosphatidylcholine binding

Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.


DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4


DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 4-RELATED


DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 2, MITOCHONDRIAL


DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 4-LIKE 1-RELATED


diterpenoid metabolic process

The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.


retinoid metabolic process

The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.


terpenoid metabolic process

The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups.


FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3


FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2


signaling receptor complex adaptor activity

The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex.


trans-Golgi network membrane

The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 24


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-6


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-3


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-1


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-4


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-1


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT DELTA


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT EPSILON


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-2


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-3


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3


NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT PI


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-2


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-3


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT THETA


GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2


amino acid binding

Binding to an amino acid, organic acids containing one or more amino substituents.


response to amino acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.


NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1


CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8


APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD


peptidase activator activity

Binds to and increases the activity of a peptidase.


PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3


PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL


mitochondrial membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.


inner mitochondrial membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane.


TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B


transcription factor TFIID complex

A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.


RNA polymerase II preinitiation complex assembly

The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.


KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 2


KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 3


KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 1


poly(A) binding

Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.


regulation of alternative mRNA splicing, via spliceosome

Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.


CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED


EH DOMAIN-BINDING PROTEIN 1-LIKE PROTEIN 1


COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG


COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG


EMBRYONIC GROWTH_DIFFERENTIATION FACTOR 1


TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN


TRANSFORMING GROWTH FACTOR BETA-2 PROPROTEIN


TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 12


SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 10


sugar transmembrane transporter activity

Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides.


glucose transmembrane transport

The process in which glucose is transported across a membrane.


histone modifying activity

A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression.


histone methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue.


histone H3K4 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein.


INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-LIKE 1


KAZAL-TYPE SERINE PROTEASE INHIBITOR DOMAIN-CONTAINING PROTEIN 1


INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7


ciliary basal body

A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.


BBSome

A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B.


non-motile cilium assembly

The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.


oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.


dioxygenase activity

Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.


aromatic amino acid metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5


RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3


RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2


RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2


RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1


RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2


RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6


RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1C


RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2


RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1


RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR


RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3


RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A


RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS1


RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4


RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1


RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B


RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1


PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2  MPV17


LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT3


LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT1


LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 2


LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2


GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT


GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA


PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA


GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 4


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 7


Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.


CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1


ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC


ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL


NADP metabolic process

The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.


GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-1


GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15


GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA


GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS XLAS


GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11


GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-2


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-3


GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z) SUBUNIT ALPHA


GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14


GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-2


GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3


GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12


GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-13


GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1


GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA


dopamine receptor binding

Binding to a dopamine receptor.


hormone receptor binding

Binding to a receptor for a hormone.


dopamine receptor signaling pathway

The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


Rho protein signal transduction

An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal.


positive regulation of lipase activity

Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.


positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.


Cdc73/Paf1 complex

A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.


basal RNA polymerase II transcription machinery binding

Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.


RNA polymerase II complex binding

Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.


basal transcription machinery binding

Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.


positive regulation of DNA-templated transcription, elongation

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


positive regulation of transcription elongation by RNA polymerase II

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


mRNA 3'-end processing

Any process involved in forming the mature 3' end of an mRNA molecule.


ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 1


ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7


ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2


ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6


ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3


ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8


NUCLEOSIDE DIPHOSPHATE PHOSPHATASE ENTPD5


ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4


nucleoside diphosphate phosphatase activity

Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate.


chromatin DNA binding

Binding to DNA that is assembled into chromatin.


VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 65


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 63


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 46


ALKALINE PHOSPHATASE, TISSUE-NONSPECIFIC ISOZYME


TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE


PROTEIN TYROSINE PHOSPHATASE DOMAIN-CONTAINING PROTEIN 1


CYCLIN-DEPENDENT KINASE INHIBITOR 3-RELATED


DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14B


DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14A


DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14C


kinocilium

A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.


stereocilium bundle

A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.


positive regulation of cell division

Any process that activates or increases the frequency, rate or extent of cell division.


MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER


39S RIBOSOMAL PROTEIN L34, MITOCHONDRIAL


KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 6


KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 3


KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 8


KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 7


KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 2


KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 12


COPII-coated vesicle budding

The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 14


TRAPP complex

A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active.


SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN


SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2


SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN


SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 3


mitotic cytokinesis

A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.


V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN


V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN


V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2A


V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2B


PROSTAGLANDIN F2 RECEPTOR NEGATIVE REGULATOR


V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4


CELL DIVISION CYCLE 7-RELATED PROTEIN KINASE


INACTIVE SERINE_THREONINE-PROTEIN KINASE VRK3


ciliary transition zone

A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.


recombinational repair

A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.


double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.


DNA recombination

Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.


double-strand break repair via break-induced replication

The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.


peptidyl-tyrosine modification

The modification of peptidyl-tyrosine.


peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA


SPERM MITOCHONDRIAL-ASSOCIATED CYSTEINE-RICH PROTEIN


rough endoplasmic reticulum

The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1D


CAM KINASE-LIKE VESICLE-ASSOCIATED PROTEIN


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA


MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA


MYOSIN LIGHT CHAIN KINASE 2, SKELETAL_CARDIAC MUSCLE


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1B


PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER_TESTIS ISOFORM


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G


PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE_HEART ISOFORM


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1


CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA


LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG


DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 3


DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 6-RELATED


DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 1


DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 4


MITOTIC-SPINDLE ORGANIZING PROTEIN 2A-RELATED


TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN


ECOTROPIC VIRAL INTEGRATION SITE 5 PROTEIN HOMOLOG


TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN


ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN


ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17A


ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17B


ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17C


thiolester hydrolase activity

Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.


neutral lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity.


acylglycerol metabolic process

The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


acylglycerol catabolic process

The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


neutral lipid metabolic process

The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.


SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3


core promoter sequence-specific DNA binding

Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.


snRNA transcription by RNA polymerase II

The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.


VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED


VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A


VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B


ER to Golgi transport vesicle membrane

The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.


SNAP receptor activity

Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.


TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT


TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1


TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4


MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2


MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1


regulation of cilium assembly

Any process that modulates the frequency, rate or extent of cilium assembly.


POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12


POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15


POLYUNSATURATED FATTY ACID 5-LIPOXYGENASE


POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15B


BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 3


MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE  MARCKS


MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE


actin filament bundle

An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.


actomyosin

Any complex of actin, myosin, and accessory proteins.


stress fiber

A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.


TESTIS-SPECIFIC PROTEIN PBS13  T-COMPLEX 11


T-COMPLEX PROTEIN 11 X-LINKED PROTEIN 1-RELATED


protein kinase A signaling

An intracellular signaling cassette that starts with the activation of protein kinase A (PKA), and ends with the regulation of a downstream cellular process, e.g. transcription. The PKA catalytic subunit (PKA-C) is normally present in a complex with its regulatory subunit, PKA-R. The inhibitory action of PKA-R is released upon cAMP binding, which results in the activation of PKA-C.


aspartate family amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.


aspartate family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED


TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11


GERM CELL-SPECIFIC GENE 1-LIKE PROTEIN 2


G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 2


G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP14


PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7


NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 17


COILED-COIL DOMAIN-CONTAINING PROTEIN 136


CENTROSOMAL PROTEIN OF 170 KDA PROTEIN B


regulation of membrane depolarization

Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.


RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3


MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 21


PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS


response to toxic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.


Hsp90 protein binding

Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.


ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN


ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3


ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2


ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 1


TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN


TUMOR PROTEIN P63-REGULATED GENE 1 PROTEIN


ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 5C-RELATED


ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 17-RELATED


protein localization to Golgi apparatus

A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.


protein localization to cilium

A process in which a protein is transported to, or maintained in, a location within a cilium.


RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS  CANCER ASSOCIATED SURFACE ANTIGEN RCAS1   ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN


RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS


CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8


CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8


Golgi transport complex

A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8.


TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11


ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8


tRNA methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.


tRNA methylation

The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.


tRNA wobble uridine modification

The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.


CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN


tumor necrosis factor-mediated signaling pathway

The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


response to tumor necrosis factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.


ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL


ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL


carbon-oxygen lyase activity

Catalysis of the breakage of a carbon-oxygen bond.


hydro-lyase activity

Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.


adenylate cyclase inhibiting G protein-coupled glutamate receptor activity

Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.


CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15


CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG


INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN


INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 5


INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 1


INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 2


INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 10


INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3


response to type I interferon

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


type I interferon-mediated signaling pathway

The series of molecular signals initiated by type I interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10


ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME


LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3


LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 12


PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1


LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8


LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4


LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 3


plasma membrane raft

A membrane raft that is part of the plasma membrane.


caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.


cargo receptor activity

Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.


low-density lipoprotein particle receptor activity

Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.


amyloid-beta clearance

The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


sterol transport

The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


intracellular sterol transport

The directed movement of sterols within cells.


intracellular cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.


cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO BETA CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 4 CHAIN-RELATED


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP ALPHA 1 CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 5 CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 3 CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 2 CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 2 CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP BETA 1 CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN


HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 55


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 52


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 26


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 38


ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2


DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1


CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE-LIKE-RELATED


CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE


protein import into nucleus

The directed movement of a protein from the cytoplasm to the nucleus.


import into nucleus

The directed movement of substances into the nucleus.


TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN


TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 1


TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 2


TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 1-LIKE 1


protein insertion into ER membrane

The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.


adenylate cyclase activity

Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.


MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR


REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1


REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG


digestion

The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


tissue homeostasis

A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.


anatomical structure homeostasis

A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA_BETA


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B


SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2


receptor signaling pathway via JAK-STAT

Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.


receptor signaling pathway via STAT

An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.


CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN


NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN


BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN


TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1


YJEF N-TERMINAL DOMAIN-CONTAINING PROTEIN 3


RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED


RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9


filopodium assembly

The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN


STEROL REGULATORY ELEMENT-BINDING PROTEIN


STEROL REGULATORY ELEMENT-BINDING PROTEIN 2


STEROL REGULATORY ELEMENT-BINDING PROTEIN 1


IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2


RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N


intracellular glucose homeostasis

A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.


response to glucose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.


PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL


toll-like receptor signaling pathway

The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN


PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B


SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM


SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM


SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM


SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM


protein serine/threonine phosphatase complex

A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.


NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1


NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1


FERRITIN HEAVY POLYPEPTIDE-LIKE 17-RELATED


maintenance of location

Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.


maintenance of location in cell

Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.


CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT GAMMA


CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT GAMMA


INACTIVE RIBONUCLEASE-LIKE PROTEIN 12-RELATED


INACTIVE RIBONUCLEASE-LIKE PROTEIN 13-RELATED


antimicrobial humoral immune response mediated by antimicrobial peptide

An immune response against microbes mediated by anti-microbial peptides in body fluid.


GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1


CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B


CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A


glycosaminoglycan metabolic process

The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.


sulfur compound catabolic process

The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.


aminoglycan metabolic process

The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.


DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER


MINICHROMOSOME MAINTENANCE DOMAIN-CONTAINING PROTEIN 2


MCM complex

A hexameric protein complex required for the initiation and regulation of DNA replication.


single-stranded DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.


cell cycle DNA replication

The DNA-dependent DNA replication that takes place as part of the cell cycle.


nuclear DNA replication

The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.


DNA unwinding involved in DNA replication

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.


mitotic DNA replication initiation

Any DNA replication initiation involved in mitotic cell cycle DNA replication.


mitotic DNA replication

Any nuclear DNA replication that is involved in a mitotic cell cycle.


DNA replication initiation

The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.


DNA strand elongation involved in DNA replication

The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.


LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72


UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14


proteasome binding

Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.


glycolytic process

The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.


Prp19 complex

A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.


URACIL NUCLEOTIDE_CYSTEINYL LEUKOTRIENE RECEPTOR


intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


INTRAFLAGELLAR TRANSPORT PROTEIN 22 HOMOLOG


melanosome

A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.


melanosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.


regulation of filopodium assembly

Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


UDP-xylosyltransferase activity

Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.


xylosyltransferase activity

Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


chondroitin sulfate proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


chondroitin sulfate proteoglycan metabolic process

The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2


S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1


N-acetyltransferase activity

Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.


ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A  ABCA


RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4


ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2


ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 6


ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 13


ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 10


ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8


ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 9


cholesterol efflux

The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE


HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2


presynaptic active zone

A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.


carboxy-lyase activity

Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.


carbon-carbon lyase activity

Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.


glutamate metabolic process

The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.


PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED


DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6


SPERM-TAIL PG-RICH REPEAT-CONTAINING PROTEIN 2


OUTER DENSE FIBER PROTEIN 3-LIKE PROTEIN 2


OUTER DENSE FIBER PROTEIN 3-LIKE PROTEIN 1


TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED


TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN-LIKE PROTEIN TPT1P8-RELATED


DISCO-INTERACTING PROTEIN 2  DIP2 -RELATED


COILED-COIL DOMAIN-CONTAINING PROTEIN 34


HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED


CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1


NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA


epsilon DNA polymerase complex

A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.


DNA polymerase complex

A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA.


The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


nucleotide-sugar metabolic process

The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


glycosphingolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.


GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 1


GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 2


EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER


tRNA threonylcarbamoyladenosine metabolic process

The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED


PHOSPHOLIPASE A2 INHIBITOR AND LY6_PLAUR DOMAIN-CONTAINING PROTEIN


SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG


transcription factor TFIIH holo complex

A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.


mediator complex

A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


cyclin-dependent protein kinase activity

Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.


cyclin-dependent protein serine/threonine kinase activity

Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


cyclin binding

Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.


regulation of G2/M transition of mitotic cell cycle

Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


regulation of dendrite development

Any process that modulates the frequency, rate or extent of dendrite development.


regulation of dendrite morphogenesis

Any process that modulates the frequency, rate or extent of dendrite morphogenesis.


G2/M transition of mitotic cell cycle

The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.


negative regulation of G2/M transition of mitotic cell cycle

Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


mitotic G2/M transition checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.


mitotic DNA integrity checkpoint signaling

A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


mitotic G2 DNA damage checkpoint signaling

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.


mitotic DNA damage checkpoint signaling

A signal transduction process involved in mitotic DNA damage checkpoint.


cell cycle G2/M phase transition

The cell cycle process by which a cell in G2 phase commits to M phase.


ubiquitin protein ligase binding

Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.


MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1


CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1


U2 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.


snRNA binding

Binding to a small nuclear RNA (snRNA).


mRNA polyadenylation

The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.


MELANIN-CONCENTRATING HORMONE RECEPTOR 1


neuropeptide binding

Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).


regulation of insulin secretion

Any process that modulates the frequency, rate or extent of the regulated release of insulin.


regulation of peptide secretion

Any process that modulates the frequency, rate, or extent of peptide secretion.


regulation of peptide hormone secretion

Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


regulation of peptide transport

Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED


aspartic-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.


SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL


respiratory chain complex

Any protein complex that is part of a respiratory chain.


respirasome

The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


mitochondrial respirasome

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


aerobic electron transport chain

A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.


tricarboxylic acid cycle

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.


mitochondrial ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.


mitochondrial electron transport, succinate to ubiquinone

The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II.


MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70


ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6


TRANSCRIPTION FACTOR SPT20 HOMOLOG-LIKE 1


TRANSCRIPTION FACTOR SPT20 HOMOLOG-LIKE 2-RELATED


stereocilium

An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.


PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 3


PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 4


PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 1


PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 2


regulation of cytosolic calcium ion concentration

Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.


C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED


microtubule polymerization or depolymerization

Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.


microtubule polymerization

The addition of tubulin heterodimers to one or both ends of a microtubule.


microtubule nucleation

The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).


intramolecular transferase activity

Catalysis of the transfer of a functional group from one position to another within a single molecule.


mRNA modification

The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine within an RNA molecule.


U12-type spliceosomal complex

Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.


pre-mRNA binding

Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.


NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1


regulation of BMP signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.


regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.


negative regulation of BMP signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.


axonemal microtubule

A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.


four-way junction DNA binding

Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.


5'-3' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.


LIM HOMEOBOX TRANSCRIPTION FACTOR 1-BETA


LIM HOMEOBOX TRANSCRIPTION FACTOR 1-ALPHA


MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER


CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN SCAMC-2


MITOCHONDRIAL COENZYME A TRANSPORTER SLC25A42


CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN SCAMC-3


CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN SCAMC-1


quaternary ammonium group transport

The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.


regulation of transforming growth factor beta receptor signaling pathway

Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.


mannosyltransferase activity

Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8


PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1


detoxification

Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 18


RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2


RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28


PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER


PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE


perikaryon

The portion of the cell soma (neuronal cell body) that excludes the nucleus.


terminal bouton

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.


positive regulation of peptide secretion

Any process that activates or increases the frequency, rate, or extent of peptide secretion.


positive regulation of peptide hormone secretion

Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


positive regulation of hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.


NEURAL RETINA-SPECIFIC LEUCINE ZIPPER PROTEIN


39S RIBOSOMAL PROTEIN L13, MITOCHONDRIAL


UDP-glucosyltransferase activity

Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule.


cellular response to amino acid starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.


EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 3


NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4 HOMOLOG A


DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED


NUCLEAR PORE COMPLEX PROTEIN NUP93  NUCLEOPORIN NUP93   DEAD EYE PROTEIN


CELL SURFACE GLYCOPROTEIN OX2 RECEPTOR PRECURSOR


CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1


CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 2


TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL


mitochondrial respiratory chain complex III assembly

The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane.


cytochrome complex assembly

The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.


HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66


U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG


TRIPARTITE MOTIF-CONTAINING PROTEIN 16-RELATED


MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE


RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1


MITOCHONDRIAL MRNA PSEUDOURIDINE SYNTHASE RPUSD3


PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL


DNA-directed DNA polymerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.


DNA polymerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group.


double-strand break repair via nonhomologous end joining

The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.


INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER


INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H1


INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2


INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4


INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3


INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5


INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H6


DISCOIDIN, CUB AND LCCL DOMAIN-CONTAINING PROTEIN 1


DISCOIDIN, CUB AND LCCL DOMAIN-CONTAINING PROTEIN 2


SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C


11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2


SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY 9C MEMBER 7


DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 9


17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2


17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6


NAD-retinol dehydrogenase activity

Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.


retinol metabolic process

The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.


U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED


U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3


NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3


NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2


NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1


HEPATOMA-DERIVED GROWTH FACTOR-LIKE PROTEIN 1


HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 3


HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 2


transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.


POST-GPI ATTACHMENT TO PROTEINS FACTOR 6


nuclear periphery

The portion of the nuclear lumen proximal to the inner nuclear membrane.


FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED


spindle midzone

The area in the center of the spindle where the spindle microtubules from opposite poles overlap.


microtubule depolymerization

The removal of tubulin heterodimers from one or both ends of a microtubule.


FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED


ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 11


racemase and epimerase activity, acting on carbohydrates and derivatives

Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.


chondroitin sulfate metabolic process

The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.


TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 3


TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 4


TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 1


TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 2


MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER


NADH dehydrogenase complex

An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.


NADH dehydrogenase activity

Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.


RIBOSOME BIOGENESIS PROTEIN BOP1  BLOCK OF PROLIFERATION 1 PROTEIN


DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2B


DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2C


DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2


dendrite development

The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.


dendrite morphogenesis

The process in which the anatomical structures of a dendrite are generated and organized.


XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2


26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11


INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4B


UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED


UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3


G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE


RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN


SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED


SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1


SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3


EXOSTOSIN  HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED


glucuronosyltransferase activity

Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.


ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1


SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER


ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4


ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 1


ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251


ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6


ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5


ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4


ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1


ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 3


lipid droplet

An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.


lipid storage

The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.


CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A


CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1


CHLORIDE INTRACELLULAR CHANNEL PROTEIN 2


CHLORIDE INTRACELLULAR CHANNEL PROTEIN 4


CHLORIDE INTRACELLULAR CHANNEL PROTEIN 3


MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR 2


PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3


MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR


PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 4


microtubule plus-end

The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.


HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN


HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E


HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN H-RELATED


MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN


MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A-RELATED


HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN


HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G


T-CELL SURFACE GLYCOPROTEIN CD1E, MEMBRANE-ASSOCIATED


HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B ALPHA CHAIN


HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN F


regulation of leukocyte mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.


positive regulation of adaptive immune response

Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.


positive regulation of lymphocyte mediated immunity

Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.


positive regulation of leukocyte mediated immunity

Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.


regulation of cell killing

Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.


TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE 3-LIKE PROTEIN


ONCOPROTEIN-INDUCED TRANSCRIPT 3 PROTEIN


ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1


CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1


TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3


PANCREATIC SECRETORY GRANULE MEMBRANE MAJOR GLYCOPROTEIN GP2


E3 UBIQUITIN-PROTEIN LIGASE HAKAI-RELATED


CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED


39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL


intraciliary transport particle A

The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.


(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME


BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6


DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN


PROTEIN KINASE DOMAIN-CONTAINING PROTEIN


SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN


SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1


COILED-COIL DOMAIN-CONTAINING PROTEIN 86


VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE


POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3


POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 2


POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1-RELATED


POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 3


POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E REGULATORY BETA SUBUNIT 5


POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 4


TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 1


TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 2


establishment of mitotic spindle localization

The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.


COILED-COIL DOMAIN-CONTAINING PROTEIN 168


LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN CCDC168


V-TYPE IMMUNOGLOBULIN DOMAIN-CONTAINING SUPPRESSOR OF T-CELL ACTIVATION


NUCLEOLAR PROTEIN FAMILY A MEMBER 1  SNORNP PROTEIN GAR1


H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1


EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN


EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1


EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2


EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3


EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8


CARBONIC ANHYDRASE 5A, MITOCHONDRIAL-RELATED


precatalytic spliceosome

A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.


MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30


SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1


COILED-COIL DOMAIN-CONTAINING PROTEIN 42


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 100


CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 73


COILED-COIL DOMAIN-CONTAINING PROTEIN 38


plasma membrane phospholipid scrambling

The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).


triglyceride biosynthetic process

The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.


triglyceride metabolic process

The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.


INACTIVE C-ALPHA-FORMYLGLYCINE-GENERATING ENZYME 2


INACTIVE PANCREATIC LIPASE-RELATED PROTEIN 1


triglyceride lipase activity

Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.


triglyceride catabolic process

The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.


FATTY ACID HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2


CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2


CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1


CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2


inner dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 10


NOTCH-REGULATED ANKYRIN REPEAT-CONTAINING PROTEIN


ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6


BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 3


GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN


ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT


ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA


STEROID TRANSMEMBRANE TRANSPORTER SLC22A24


SOLUTE CARRIER FAMILY 22 MEMBER 31-RELATED


quaternary ammonium group transmembrane transporter activity

Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.


ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 1


ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 2


regulation of B cell activation

Any process that modulates the frequency, rate or extent of B cell activation.


regulation of B cell proliferation

Any process that modulates the frequency, rate or extent of B cell proliferation.


glycogen biosynthetic process

The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.


glucan biosynthetic process

The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.


MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46


mitochondrial fission

The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN


REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2


REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A


REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1B


FATTY ACID DESATURASE 2-LIKE PROTEIN FADS2B-RELATED


SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT


SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT


SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT


CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6


ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2


INTERFERON-INDUCED GTP-BINDING PROTEIN MX1


INTERFERON-INDUCED GTP-BINDING PROTEIN MX2


DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL


MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN


TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561


PLASMA MEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYBRD1


LYSOSOMAL MEMBRANE ASCORBATE-DEPENDENT FERRIREDUCTASE CYB561A3


RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C


ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2


ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1


ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3


OLFACTORY RECEPTOR FAMILY 1 SUBFAMILY R MEMBER 1 PSEUDOGENE


PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 2


PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 4


PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 3


PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 1


GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN 2


PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8


SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL


INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4


SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 3


SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 1


SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 2


MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER


ENDOPLASMIC RETICULUM MEMBRANE ADAPTER PROTEIN XK


ubiquitin binding

Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.


TISSUE-RESIDENT T-CELL TRANSCRIPTION REGULATOR PROTEIN ZNF683


TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1


ESCRT I complex

An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.


ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.


NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121


NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121C-RELATED


ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI


ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 6


ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 8


ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 4


V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT


V-TYPE PROTON ATPASE 21 KDA PROTEOLIPID SUBUNIT C''


V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C


ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3


ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10


G PATCH DOMAIN-CONTAINING PROTEIN 2-LIKE


fucosyltransferase activity

Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1


positive regulation of phagocytosis

Any process that activates or increases the frequency, rate or extent of phagocytosis.


exosome (RNase complex)

A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.


C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 2


C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1


MAPK cascade

An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.


stress-activated protein kinase signaling cascade

The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.