regulation of dauer larval development

Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.


plasmid recombination

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules.


secologanin synthase activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O.


G protein-coupled opioid receptor activity

Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.


aerobic phenol-containing compound metabolic process

The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen.


positive regulation of cholesterol storage

Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


negative regulation of molecular function in another organism

Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism.


interleukin-17F production

The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


mesothelial-mesenchymal cell signaling involved in early lung development

Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung.


W-molybdopterin cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.


snRNA pseudouridylation guide activity

Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule.


G protein-coupled chemoattractant receptor activity

Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


cellular response to salt stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


aculeacin-A deacylase activity

Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain.


positive regulation of hematopoietic progenitor cell differentiation

Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.


musculoskeletal movement

The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.


(R)-mandelate dehydrogenase activity

Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor.


mammary gland alveolus development

The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.


9-fluorenone dioxygenase activity

Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone.


Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene.


(E)-caffeate-CoA ligase activity

Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate.


cholesterol 25-hydroxylase activity

Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O.


regulation of leukocyte differentiation

Any process that modulates the frequency, rate or extent of leukocyte differentiation.


lipid A-core heptosyltransferase activity

Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+.


alpha,alpha-phosphotrehalase activity

Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate.


arachidonate 8(S)-lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.


peptidyl-arginine methylation, to symmetrical-dimethyl arginine

The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine.


positive regulation of membrane depolarization during AV node cell action potential

Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential.


Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O.


stellate cell precursor proliferation

The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


alkylamidase activity

Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylammonium.


3-phenylpropionate metabolic process

The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins.


positive regulation of seed germination

Any process that activates or increase the rate of seed germination.


fungal-type cell wall assembly

The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall.


vitamin transmembrane transporter activity

Enables the transfer of a vitamin from one side of a membrane to the other.


deNEDDylase activity

An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.


methionine adenosyltransferase activity

Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.


sepiapterin reductase activity

Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+.


Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine.


female germline ring canal stabilization

Maintenance of the structural integrity of the ring canals connecting the female germline cyst.


response to sulfur dioxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus.


long-chain fatty-acyl-CoA metabolic process

The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol.


intracellular nickel ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of nickel ions within a cell.


regulation of plus-end directed microtubule sliding

Any process that mediates the frequency, rate, or extent of plus-end directed microtubule sliding.


unsubstituted mannan metabolic process

The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units.


phospholipid scramblase activity

Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.


response to differentiation-inducing factor 1

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus.


DDT 2,3-dioxygenase activity

Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT.


XCL1 production

The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


eukaryotic translation initiation factor 2B complex assembly

The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2B complex.


cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity

Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) = cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A.


myelination of posterior lateral line nerve axons

The formation of compact myelin sheaths around the axons of the posterior lateral line nerve.


pimeloyl-CoA dehydrogenase activity

Catalysis of the reaction: NAD+ + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H+ + NADH.


post-embryonic pectoral fin morphogenesis

The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.


galactose transmembrane transporter activity

Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.


Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.


myeloid cell activation involved in immune response

A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.


induction of conjugation upon nitrogen starvation

The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation.


quinate 3-dehydrogenase (NADP+) activity

Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+.


positive regulation of growth plate cartilage chondrocyte proliferation

Any process that increases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


convergent extension involved in mesonephric nephron morphogenesis

The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros.


vegetative to reproductive phase transition of meristem

The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.


1,6-anhydro-N-acetyl-beta-muramic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid.


enterobactin catabolic process

The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway.


messenger ribonucleoprotein complex assembly

The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex.


fucoidanase activity

Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate.


tendon cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.


methyl fluoride metabolic process

The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils.


N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity

Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide.


sperm storage

The retention of sperm by a female following mating.


glycine betaine-activated nonselective monoatomic cation channel activity

Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts.


urea cycle

The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.


regulation of female gonad development

Any process that modulates the frequency, rate or extent of female gonad development.


AMP-activated protein kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP.


protein localization to eisosome filament

A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.


Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O.


detection of oxidative stress

The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.


GDP-L-galactose biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate.


metanephric interstitial fibroblast fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast.


negative regulation of monoatomic ion transmembrane transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.


brush border assembly

The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border.


streptomycin biosynthetic process

The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.


spore encystment

The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol.


methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.


forked DNA-dependent helicase activity

Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis.


Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP.


dihydroneopterin aldolase activity

Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.


Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate.


neuronal pentraxin receptor activity

Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+.


calcium-release channel activity

Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.


positive regulation of collecting lymphatic vessel constriction

Any process that activates or increases the frequency, rate or extent of collecting lymphatic vessel constriction.


mitochondrial translational termination

The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).


Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H+ + lipid IV(a).


diamine oxidase activity

Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide.


positive regulation of asexual sporulation resulting in formation of a cellular spore

Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis.


galactose to glucose-1-phosphate metabolic process

The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate.


glutathione derivative biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione derivative.


tRNA (guanine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine.


symbiont-mediated pore formation in host plasma membrane

The disruption of host plasma membrane integrity by formation of a pore, resulting in deregulated ion homeostasis, and cellular dysfunction that can result in cell death.


olfactory nerve formation

The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


receptor localization to non-motile cilium

A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium.


female gamete generation

Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.


pre-mRNA branch point binding

Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site.


tetrapeptide transmembrane transporter activity

Enables the transfer of tetrapeptide from one side of a membrane to the other.


Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine.


The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


regulation of conjugation with cellular fusion

Any process that modulates the rate or frequency of conjugation with cellular fusion.


peptidyl-histidine methylation, to form tele-methylhistidine

The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).


basement membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.


diphosphate metabolic process

The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid.


Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate.


alpha-bisabolene synthase activity

Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate.


envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism

A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism.


ligase activity, forming carbon-nitrogen bonds

Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration

The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.


cellular response to methylamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus.


renal interstitial fibroblast development

The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure.


negative regulation of cell fate determination

Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination.


symbiont-mediated stabilization of host tight cell-cell junction

The process in which a symbiont organism that stabilizes the its host tight cell-cell junctions, making them less dynamic. The tight junction is a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other, and plays a role in the inflammatory response of the host.


lymphocyte apoptotic process

Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


protein localization to ciliary membrane

A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.


acyltransferase activity, acyl groups converted into alkyl on transfer

Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.


4-hydroxymandelate synthase activity

Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2.


regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling

Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell.


hydroxylamine oxidoreductase activity

Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor.


ventricular septum intermedium morphogenesis

The developmental process in which a ventricular septum intermedium is generated and organized.


methylglyoxal catabolic process to lactate

The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate.


Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate.


cytoskeletal matrix organization at active zone

The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane.


reduced coenzyme F420:heterodisulfide oxidoreductase activity

Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH.


global genome nucleotide-excision repair

The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome.


larval walking behavior

The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.


negative regulation of heterotypic cell-cell adhesion

Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.


glycolate catabolic process

The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid).


FAD-AMP lyase (cyclizing) activity

Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate.


Gq/11-coupled serotonin receptor activity

Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.


C-C chemokine receptor activity

Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.


cold-induced thermogenesis

The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature.


oenocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.


The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydrosarcinapterin.


floral whorl development

The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant.


cutin biosynthetic process

The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants.


nicotine dehydrogenase activity

Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor.


positive regulation of cell differentiation involved in phenotypic switching

Any process that activates or increases the frequency, rate or extent of cell differentiation involved in phenotypic switching.


pyrrolizidine alkaloid biosynthetic process

The chemical reactions and pathways resulting in the formation of pyrrolizidine alkaloid.


URM1 transferase activity

Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages.


optic nerve maturation

A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


sterol O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.


ER-nucleus signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.


endodeoxyribonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.


galactomannan metabolic process

The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units.


The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


Peyer's patch development

The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.


cellular response to UV

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


platelet morphogenesis

Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.


haloalkane dehalogenase activity

Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide.


Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.


autophagosome localization

Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell.


ciliary neurotrophic factor receptor activity

Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


reductive tricarboxylic acid cycle

A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.


alanine racemase activity

Catalysis of the reaction: L-alanine = D-alanine.


regulation of Toll signaling pathway

Any process that modulates the frequency, rate or extent of the Tl signaling pathway.


erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid.


response to cytochalasin B

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus.


rhombomere 3 morphogenesis

The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


beak development

The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus.


Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2.


Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.


The chemical reactions and pathways resulting in the formation of beta-D-galactofuranose.


maternal aggressive behavior

Aggressive behavior of a female to protect her offspring from a threat.


regulation of conidium formation

Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.


activated CD8-positive, alpha-beta T cell apoptotic process

Any apoptotic process in an activated CD8-positive, alpha-beta T cell.


G protein-coupled nucleotide receptor activity

Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+.


response to muscle activity involved in regulation of muscle adaptation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation.


positive regulation of ventricular cardiac muscle cell action potential

Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential.


cerebellar cortex morphogenesis

The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


long-chain fatty acid binding

Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


shelterin complex assembly

The aggregation, arrangement and bonding together of a set of components to form a shelterin complex. A shelterin complex is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase.


positive regulation of circadian rhythm

Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.


negative regulation of arabinoxylan-containing compound catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of arabinoxylan-containing compound catabolic process.


response to protozoan

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.


regulation of nematode male tail tip morphogenesis

Any process that modulates the frequency, rate or extent of nematode male tail tip morphogenesis, the process in which the anatomical structure of the adult male tail tip is generated and organized.


Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ = 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid.


shoot system morphogenesis

The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground.


'de novo' L-methionine biosynthetic process

The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components.


ADP-ribosyl-[dinitrogen reductase] hydrolase activity

Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase].


MBF transcription complex assembly

The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex.


pyruvate family amino acid metabolic process

The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine.


voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.


Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH.


cellular response to arsenite(3-)

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus.


stress response to copper ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus.


CO-methylating acetyl-CoA synthase activity

Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA.


regulation of vegetative phase change

Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development.


regulation of CD4-positive, alpha-beta T cell differentiation

Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.


taxane 13-alpha-hydroxylase activity

Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5alpha,13alpha-diol.


primary lung bud formation

The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.


arachidonate transmembrane transporter activity

Enables the transfer of arachidonate from one side of a membrane to the other.


vinorine hydroxylase activity

Catalysis of the reaction: H+ + NADPH + O2 + vinorine = H2O + NADP+ + vomilenine.


positive regulation of gamma-delta T cell activation involved in immune response

Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response.


radial spoke assembly

The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules.


exit of virus from host cell nucleus

The directed movement of the viral genome or a viral particle out of the host cell nucleus.


chitin biosynthetic process

The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


negative regulation of establishment or maintenance of neuroblast polarity

Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity.


Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends.


somatostatin receptor signaling pathway

A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process.


positive regulation of cardioblast differentiation

Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


heparan sulfate proteoglycan metabolic process

The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.


Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate.


fatty acid beta-oxidation using acyl-CoA dehydrogenase

A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).


The chemical reactions and pathways involving 4-hydroxyphenylacetate.


positive regulation of D-aspartate import across plasma membrane

Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.


negative regulation of type II interferon-mediated signaling pathway

Any process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.


regulation of laminaritriose transport

Any process that modulates the frequency, rate or extent of laminaritriose transport.


liver regeneration

The regrowth of lost or destroyed liver.


efferent axon development in a lateral line nerve

The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve.


cellular response to mercury ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.


glutamine N-acyltransferase activity

Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.


Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein].


hemicellulose metabolic process

The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present.


MHC class II biosynthetic process

The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.


positive regulation of transport across blood-brain barrier

Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier.


telencephalon regionalization

The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.


regulation of non-canonical Wnt signaling pathway

Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway.


pigment accumulation in response to UV light

The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus.


regulation of CD8-positive, alpha-beta T cell activation

Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.


hindbrain radial glia guided cell migration

The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain.


dGMP metabolic process

The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate).


regulation of intracellular steroid hormone receptor signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


intracellular magnesium ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of magnesium ions within a cell.


prepulse inhibition

The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse.


negative regulation of striated muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.


ingression involved in gastrulation with mouth forming second

The migration of individual cells into the embryo involved in deuterostomic gastrulation.


negative regulation of late stripe melanocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation.


positive regulation of iron ion transmembrane transport

Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore.


Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol.


pectin catabolic process

The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.


lymph vessel morphogenesis

The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph.


cytochrome metabolic process

The chemical reactions and pathways involving a cytochrome.


L-glutamine aminotransferase activity

Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid.


protein demethylase activity

Catalysis of the removal of a methyl group from a protein.


amyloid fibril formation

The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.


cephalosporinase activity

Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin.


modulation by host of symbiont catalytic activity

The process in which a host organism effects a change in the enzyme activity of its symbiont organism.


post-embryonic retina morphogenesis in camera-type eye

The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage.


histone H3 ubiquitin ligase activity

Catalysis of the transfer of ubiquitin to a histone H3 substrate.


negative regulation of odontoblast differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation.


histone H3K23 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23).


heart wedging

The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart.


protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity

Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


leucophore differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance.


tRNA gene clustering

The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae.


symbiont-mediated disruption of host cell nucleus

The process in which an organism effects a change that impairs the structure or function of the host cell nucleus.


Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H.


symbiont-mediated perturbation of host defense response

A process in which a symbiont interferes with the ability of the host to mount a defense in response to its presence. The host is defined as the larger of the organisms involved in a symbiotic interaction.


methane catabolic process

The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes.


negative regulation of appetite by leptin-mediated signaling pathway

The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.


Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA.


rubredoxin-NADP+ reductase activity

Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+.


spinal cord oligodendrocyte cell differentiation

The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.


Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite.


beta-alanine biosynthetic process via 3-hydroxypropionate

The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in).


germarium-derived oocyte fate determination

The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster.


regulation of cold-induced thermogenesis

Any process that modulates the frequency, rate or extent of cold-induced thermogenesis.


vascular endothelial cell response to fluid shear stress

Any response to fluid shear stress in a vascular endothelial cell.


fumonisin catabolic process

The chemical reactions and pathways resulting in the breakdown of fumonisin.


positive regulation of olefin metabolic process

Any process that activates or increases the frequency, rate or extent of olefin metabolic process.


regulation of cellular response to alcohol

Any process that modulates the frequency, rate or extent of cellular response to alcohol.


SCF ubiquitin ligase complex binding

Binding to a SCF ubiquitin ligase complex.


chitin synthase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).


regulation of cell proliferation in dorsal spinal cord

The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord.


leukotriene receptor activity

Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine.


carbon dioxide binding

Binding to carbon dioxide.


UDP-D-galacturonate metabolic process

The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate.


negative regulation of anion transmembrane transport

Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport.


L-gulonate 3-dehydrogenase activity

Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH.


aryl sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.


symbiont-mediated suppression of host antigen processing and presentation

A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC protein complex.


protein-bilin linkage

The covalent linkage of bilin and a protein.


stomium development

The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released.


Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP.


pronephric glomerulus morphogenesis

The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.


phthalate binding

Binding to a phthalate, any ester or salt of phthalic acid.


ABC-type iron-sulfur cluster transporter activity

Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out).


rhombomere 1 structural organization

The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


glucanosyltransferase activity

Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation.


perillic acid-CoA ligase (AMP-forming) activity

Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA.


2-propylphenol monooxygenase activity

Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD.


dihydroorotate dehydrogenase activity

Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.


Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O.


thymus epithelium morphogenesis

The process in which the thymus epithelium is generated and organized.


response to rapamycin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus.


acylglycerol biosynthetic process

The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


intestinal epithelial cell migration

The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.


forebrain neuroblast differentiation

The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.


ATP-sensitive calcium-release channel activity

Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts.


thymidine metabolic process

The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.


Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate.


cardioblast cell midline fusion

The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment.


peptidyl-arginine N-methylation

The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein.


acrosome matrix dispersal

The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane.


ribonucleoside biosynthetic process

The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.


response to glutathione

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus.


molybdenum incorporation into molybdenum-molybdopterin complex

The incorporation of molybdenum into a molybdenum-molybdopterin complex.


protein arginylation

The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.


regulation of glycerol transport

Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


negative regulation of smooth endoplasmic reticulum calcium ion concentration

Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum.


envenomation resulting in negative regulation of heart rate in another organism

A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism.


rhombomere 7 formation

The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


regulation of lymphocyte differentiation

Any process that modulates the frequency, rate or extent of lymphocyte differentiation.


Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor.


cell motility in response to potassium ion

Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus.


negative regulation of circadian sleep/wake cycle, REM sleep

Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.


glutathione thiolesterase activity

Catalysis of the reaction: S-acylglutathione + H2O = a carboxylate + glutathione + H+.


stamen formation

The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts.


organ or tissue specific immune response

An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.


rhombomere 4 morphogenesis

The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate.


protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine

The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine.


pentadec-1-ene metabolic process

The chemical reactions and pathways involving pentadec-1-ene.


asparagine biosynthetic process from oxaloacetate

The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate.


dinitrosyl-iron complex binding

Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.


homoaconitate hydratase activity

Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O.


Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+.


phosphoketolase activity

Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O.


positive regulation of vitamin D receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity.


intrinsic apoptotic signaling pathway in response to osmotic stress

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.


G protein-coupled enkephalin receptor activity

Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.


pons structural organization

The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.


positive regulation of cardiac vascular smooth muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation.


RNA glycosylase activity

Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule.


apigenin 7-O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate = S-adenosyl-L-homocysteine + genkwanin.


Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate.


growth plate cartilage chondrocyte proliferation

The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein].


cellular response to inorganic substance

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.


symbiont-mediated perturbation of host Rab signal transduction

A process in which a symbiont alters a Rab protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).


canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation.


B-1 B cell homeostasis

The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


negative regulation of neuron migration

Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.


negative regulation of L-arginine import across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of L-arginine import across plasma membrane.


thiaminase activity

Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+.


Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).


glial cell-neuron signaling

Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.


starch metabolic process

The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.


positive regulation of osteoclast development

Any process that activates or increases the frequency, rate or extent of osteoclast development.


evasion of DNA end degradation by host

A process by which a symbiont evades and ends degradation of its DNA when free DNA ends are exposed. DNA ends are exposed during the life cycle of some viruses and these are targeted by host cells to destroy the virus. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases.


Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine.


multi-organism reproductive process

A biological process that directly contributes to the process of producing new individuals, involving another organism.


ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential

Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.


tryptophan 5-monooxygenase activity

Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.


positive regulation of ascospore formation

Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus.


cholesterol dehydrogenase activity

Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+.


Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O.


salicylic acid glucosyltransferase (ester-forming) activity

Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP.


L-xylulokinase activity

Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate.


Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate.


collagen V binding

Binding to a type V collagen trimer.


perturbation of host induced systemic resistance

A process in which an organism effects a change that affects the induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid = L-homomethionine + a 2-oxo carboxylate.


Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate.


negative regulation of vitamin metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


multicellular organismal-level chemical homeostasis

A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.


cholesterol sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+.


Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.


cellular response to oxygen radical

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion.


maintenance of imaginal histoblast diploidy

The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells.


sulfiredoxin activity

Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.


negative regulation of memory T cell differentiation

Any process that stops, prevents, or reduces the rate of memory T cell differentiation.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in).


pectoral fin morphogenesis

The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.


synaptic vesicle clustering

The process that results in grouping synaptic vesicles in presynaptic structures.


lung induction

The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung.


signal clustering

Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.


xylan acetylation

The addition of one or more acetyl groups to a xylan molecule.


epidermal growth factor receptor ligand maturation

Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.


dihydromethanopterin reductase activity

Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP.


maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.


cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity

Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose.


fruit development

The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant.


leg disc anterior/posterior pattern formation

The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc.


regulation of artery smooth muscle contraction

Any process that modulates the frequency, rate or extent of artery smooth muscle contraction.


K antigen metabolic process

The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens.


The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system.


socket cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support.


negative regulation of action potential

Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


negative regulation of retina development in camera-type eye

Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye.


lipoate synthase activity

Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.


Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O.


positive regulation of cornification

Any process that activates or increases the frequency, rate or extent of cornification.


negative regulation of ATP citrate synthase activity

Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity.


germ cell migration

The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.


regulation of systemic arterial blood pressure by circulatory renin-angiotensin

The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.


Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 = 2-exo-hydroxy-1,8-cineole + NADP + H2O.


regulation of entry of bacterium into host cell

Any process that modulates the frequency, rate or extent of entry of bacterium into host cell.


gas vesicle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps.


3-hydroxybutyryl-CoA epimerase activity

Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.


peptidyl-lysine deglutarylation

The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein.


inhibitory postsynaptic potential

A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.


regulation of transmission of nerve impulse

Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.


positive regulation of toll-like receptor 13 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway.


regulation of icosanoid secretion

Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell.


regulation of cardiac muscle cell apoptotic process

Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.


regulation of mesodermal cell fate determination

Any process that modulates the frequency, rate or extent of mesoderm cell fate determination.


Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA.


RNA nucleotide deletion

The modification of an RNA molecule by removal of a single nucleotide.


symbiont-mediated suppression of host MAPK cascade

A process in which a symbiont interferes with, inhibits or disrupts a MAPK signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol.


branching involved in open tracheal system development

The process in which the anatomical structures of branches in the open tracheal system are generated and organized.


MCM complex assembly

The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication.


endoplasmic reticulum stress-induced pre-emptive quality control

The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome.


gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity

Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide.


threonine efflux transmembrane transporter activity

Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane.


snRNA modification

The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA.


nitric-oxide synthase biosynthetic process

The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.


Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.


long-term synaptic potentiation

A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.


positive regulation of appetite

Any process that increases appetite.


Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+.


apoptotic nuclear changes

Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.


3-hydroxybenzyl alcohol metabolic process

The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum.


2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity

Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose.


Catalysis of the reaction: dehydroabietadienal + NADPH + O2 = dehydroabietic acid + NADP + H2O.


negative regulation of hemostasis

Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis.


A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation.


ocellus pigmentation

The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates.


negative gravitropism

The orientation of plant parts away from gravity.


Hsp90 deacetylation

The modification of an Hsp90 protein by removal of acetyl groups.


co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

Any process involved in transcription termination-coupled 3' processing of RNA polymerase II mRNA transcripts by the 3' end cleavage and addition of a poly(A) tail. This pathway is required for the maturation of primary protein-encoding transcripts into functional mRNAs that can be exported from the nucleus and translated in the cytoplasm, but is also required for polyadenylation-dependent decay.


sensory perception of touch

The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).


naphthalene disulfonate 1,2-dioxygenase activity

Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene).


negative regulation of proton-transporting ATP synthase activity, rotational mechanism

Any process that stops, prevents or reduces the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism.


maintenance of chromosome location

Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere.


tubulin-tyrosine carboxypeptidase

Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine.


self proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.


adenohypophysis formation

The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.


U3 snoRNA binding

Binding to a U3 small nucleolar RNA.


3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity

Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain.


granum assembly

A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts.


myeloid progenitor cell differentiation

The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.


Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + H+ + NADPH.


response to cisplatin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.


Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + hesperetin(1-) + S-adenosyl-L-homocysteine.


negative regulation of T cell differentiation in thymus

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.


dCDP catabolic process

The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate.


trophectodermal cellular morphogenesis

The morphogenesis of trophectoderm cells.


response to DNA replication checkpoint signaling

A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling.


aspartyl-tRNA aminoacylation

The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA.


Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA.


negative regulation of white fat cell proliferation

Any process that stops or decreases the rate or extent of white fat cell proliferation.


arachidonate-CoA ligase activity

Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+.


positive regulation of glucocorticoid mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway.


The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


neuromuscular junction development, skeletal muscle fiber

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber.


interferon-kappa production

The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


intestinal epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.


cell adhesion involved in dendrite retrograde extension

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite.


response to cytokinin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.


Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide.


mitotic prophase

The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.


corticospinal neuron axon guidance through the medullary pyramid

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues.


red or far-red light signaling pathway

The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.


ribulose bisphosphate carboxylase complex assembly

The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex.


nitrite reductase activity

Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor.


negative regulation of lymphangiogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis.


regulation of endothelial cell chemotaxis to fibroblast growth factor

Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor.


actin phosphorylation

The transfer of one or more phosphate groups to an actin molecule.


symbiont-mediated perturbation of host receptor-mediated signal transduction

A process by which a symbiont alters or subverts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


choline monooxygenase activity

Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O.


lincomycin metabolic process

The chemical reactions and pathways involving lincomycin.


regulation of natural killer cell apoptotic process

Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process.


regulation of nitric oxide mediated signal transduction

Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).


response to cholecystokinin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus.


mitochondrial respirasome assembly

The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.


galactose catabolic process via D-galactonate

The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate.


putamen development

The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.