regulation of secondary metabolic process

Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.


positive regulation of cardiac muscle adaptation

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.


symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity

A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).


regulation of endothelial cell development

Any process that modulates the frequency, rate or extent of endothelial cell development.


cordyol C biosynthetic process

The chemical reactions and pathways resulting in the formation of cordyol C.


retinal cell programmed cell death

Programmed cell death that occurs in the developing retina.


hematopoietic stem cell migration

The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.


G protein-coupled purinergic nucleotide receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process.


response to 4-nitroquinoline N-oxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus.


chlorophyllide a oxygenase [overall] activity

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+.


protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine

Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues.


type II interferon production

The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.


double layer follicle stage

The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus.


gibberellic acid mediated signaling pathway, G-alpha-independent

The series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors.


mannosylglycerate biosynthetic process

The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms.


nicotinic acid riboside kinase activity

Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide.


ornithine metabolic process

The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.


cellular response to vitamin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.


endoplasmic reticulum localization

Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell.


nicotinic acid riboside biosynthetic process

The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid.


positive regulation of penetration hypha formation

Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction.


dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.


L-lactate dehydrogenase (cytochrome) activity

Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.


endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)

Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.


negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.


abscisic acid-activated signaling pathway

The series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.


meiotic interphase

The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA.


aortic valve morphogenesis

The process in which the structure of the aortic valve is generated and organized.


regulation of Rac protein signal transduction

Any process that modulates the frequency, rate or extent of Rac protein signal transduction.


regulation of photoperiodism, flowering

Any process that modulates the frequency, rate or extent of photoperiodism, flowering.


high-affinity ferrous iron transmembrane transporter activity

Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


cyanophycin synthetase activity (L-aspartate-adding)

Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp.


hypotaurine dehydrogenase activity

Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine.


Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+.


parturition

The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.


maintenance of kidney identity

The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


proteasome core complex binding

Binding to a proteasome core complex.


septin collar organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar.


sequestering of extracellular ligand from receptor

The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.


leukocyte chemotaxis involved in inflammatory response

The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.


retinol isomerase activity

Catalysis of the reaction: all-trans-retinol = 11-cis-retinol.


paraxial mesoderm structural organization

The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure.


regulation of cell proliferation in midbrain

Any process that modulates the frequency, rate or extent of cell proliferation in midbrain.


cell budding

A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell.


ISG15-specific peptidase activity

A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated.


protein auto-ADP-ribosylation

The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.


chondrocyte development involved in endochondral bone morphogenesis

The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.


Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate.


T cell aggregation

The adhesion of one T cell to one or more other T cells via adhesion molecules.


Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone.


regulation of epithelial cell apoptotic process

Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process.


phthalate 4,5-dioxygenase activity

Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+.


viral DNA cleavage involved in viral genome maturation

The cleavage of viral DNA into singular functional units.


centromere localization

A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location.


cerebellar Purkinje cell layer formation

The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


negative regulation of transcytosis

Any process that stops, prevents or reduces the frequency, rate or extent of transcytosis.


myotube differentiation

The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


response to photooxidative stress

Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.


regulation of epinephrine uptake

Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell.


high-affinity phosphate transmembrane transporter activity

Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


estrone sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.


neuroblast migration

The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.


somatic processes downstream of sex determination signal

The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways.


thyroid hormone metabolic process

The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


nucleoside salvage

Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis.


protein-RNA complex remodeling

The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex.


dermatan sulfate catabolic process

The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


monensin A biosynthetic process

The chemical reactions and pathways resulting in the formation of monensin A.


aminolevulinate transaminase activity

Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine.


hydroxylysine metabolic process

The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases.


alcohol O-octanoyltransferase activity

Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester.


Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ = 4-pregnen-20,21-diol-3-one + NAD.


pH-gated monoatomic ion channel activity

Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH).


Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+.


Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O.


regulation of neuron migration

Any process that modulates the frequency, rate or extent of neuron migration.


regulation of Schwann cell proliferation

Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


regulation of tumor necrosis factor-mediated signaling pathway

Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.


positive regulation of early endosome to late endosome transport

Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.


amnioserosa maintenance

Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis.


oxylipin metabolic process

The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.


regulation of response to toluene

Any process that modulates the frequency, rate or extent of response to toluene.


convergent extension involved in axis elongation

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.


phytochelatin biosynthetic process

The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11.


progesterone 21-hydroxylase activity

Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


regulation of atrial cardiac muscle cell membrane depolarization

Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte.


third ventricle development

The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina.


positive regulation of connective tissue replacement

Any process that activates or increases the frequency, rate or extent of connective tissue replacement.


L-lactate dehydrogenase activity

Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.


sinus venosus development

The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.


inosinate nucleosidase activity

Catalysis of the reaction: H2O + IMP = D-ribose 5-phosphate + hypoxanthine.


cellular response to growth hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.


pseurotin A biosynthetic process

The chemical reactions and pathways resulting in the formation of pseurotin A.


positive regulation of cardiac ventricle formation

Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation.


lead sulfide oxidation

The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate.


detoxification of cadmium ion

Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion.


nucleus ambiguus development

The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure.


D-glutamate cyclase activity

Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O.


positive regulation of parathyroid hormone secretion

Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion.


germ cell repulsion

The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue.


negative regulation of mammary stem cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation.


phloroglucinol reductase activity

Catalysis of the reaction: dihydrophloroglucinol + NADP+ = H+ + NADPH + phloroglucinol.


gallbladder development

The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile.


lipoteichoic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


striated muscle contraction involved in embryonic body morphogenesis

The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology.


regulation of fat cell proliferation

Any process that modulates the frequency, rate or extent of fat cell proliferation.


dATP catabolic process

The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).


fruit valve development

The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces.


root hair cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a root hair cell.


enniatin metabolic process

The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores.


stem cell fate determination

The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed.


dehydroquinate synthase activity

Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+.


regulation of Schwann cell chemotaxis

Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis.


Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate.


glutamine binding

Binding to glutamine, 2,5-diamino-5-oxopentanoic acid.


negative regulation of oxidative phosphorylation uncoupler activity

Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity.


positive regulation of the force of heart contraction by circulating epinephrine

The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction.


vegetative phase change

Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development.


nerve growth factor production

The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels.


co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway

Any process involved in transcription termination-coupled 3' processing of RNA polymerase II RNA transcripts by 3' end cleavage and addition of a poly(A) tail. This pathway is required for the maturation of primary protein-encoding transcripts into functional RNAs that can be exported from the nucleus and translated in the cytoplasm, but is also required for polyadenylation-dependent decay.


2-hydroxypropyl-CoM lyase activity

Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane.


regulation of synaptic plasticity by receptor localization to synapse

Any process that modulates synaptic plasticity, the ability of synapses to change as circumstances require, via receptor localization to the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. Processes may include receptor transport to, and/or maintenance at, the synapse.


poly-N-methyl-propylamination

The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin.


positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


bacterial-type flagellum-dependent cell motility

Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.


mast cell cytokine production

Any process that contributes to cytokine production by a mast cell.


positive regulation of vascular associated smooth muscle cell apoptotic process

Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.


glyoxal oxidase activity

Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2.


tube closure

Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold.


cytidine transmembrane transporter activity

Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other.


positive regulation of skeletal muscle satellite cell differentiation

Any process that activates or increases the frequency, rate or extent of satellite cell differentiation.


hypochlorous acid biosynthetic process

The chemical reactions and pathways resulting in the formation of hypochlorous acid.


methyl jasmonate methylesterase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate.


glucoside 3-dehydrogenase activity

Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor.


regulation of establishment or maintenance of cell polarity regulating cell shape

Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape.


positive regulation of meiotic chromosome separation

Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation.


ammonium excretion

The elimination of ammonium ions from an excretory cell.


follicular B cell differentiation

The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.


Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide.


(+)-camphor biosynthetic process

The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone.


endospore formation

The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions.


ornaline synthase activity

Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ = ornaline + NADP + H2O.


Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 34 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 34 in tRNA.


Tie signaling pathway

The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


venous endothelial cell fate commitment

The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell.


negative regulation of cardiac muscle adaptation

Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.


cardiac pacemaker cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.


P-type sodium transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism.


podocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells.


Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light.


Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate.


Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH.


transsulfuration

The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.


glucuronate catabolic process

The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid.


glycolate transmembrane transporter activity

Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA).


response to symbiont defenses

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


cystathionine gamma-synthase activity

Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.


Z-farnesyl diphosphate synthase activity

Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate.


DNA strand displacement

The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.


host-mediated regulation of oral microbiota composition

The biological process involved in maintaining the steady-state number of cells within a population of free-living cells, such as the bacteria, in the mouth.


Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid.


notochord development

The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.


endothelial cell chemotaxis to vascular endothelial growth factor

The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF).


regulation of chondrocyte differentiation involved in endochondral bone morphogenesis

Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.


intermediate filament polymerization

Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.


negative regulation of retinal cone cell fate commitment

Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell.


establishment of mitochondrion localization

The directed movement of the mitochondrion to a specific location.


pyridine nucleoside metabolic process

The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose.


maintenance of CRISPR repeat elements

Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences.


Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA.


spiracle morphogenesis, open tracheal system

The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.


oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound.


negative regulation of Kit signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway.


metanephric cap mesenchymal cell proliferation involved in metanephros development

The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip.


Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate.


alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity

Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP.


response to beta-carotene

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus.


neurotransmitter receptor diffusion trapping

The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane.


positive regulation of secondary growth

Any process that activates or increases the frequency, rate or extent of secondary growth.


spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)

Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).


xylan metabolic process

The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone.


protein farnesylation

The covalent attachment of a farnesyl group to a protein.


G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.


corticosterone binding

Binding to corticosterone.


galactose catabolic process via UDP-galactose

The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.


positive regulation of atrichoblast fate specification

Any process that induces or promotes atrichoblast fate specification.


pheromone-dependent signal transduction involved in conjugation with cellular fusion

A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.


octopamine biosynthetic process

The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species.


regulation of leukocyte apoptotic process

Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.


pyroptosome complex assembly

The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex.


steroid sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.


melatonin biosynthetic process

The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine).


oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen.


cardiac muscle cell contraction

The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.


maltose binding

Binding to maltose.


ice binding

Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal.


anaerobic 2-aminobenzoate metabolic process

The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen.


main body follicle cell migration

The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte.


embryonic pectoral fin morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.


septal cell proliferation

The multiplication or reproduction of septal cells, resulting in the expansion of a cell population.


N-ethylmaleimide reductase activity

Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+.


negative regulation of endocytic recycling

Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling.


lens placode formation involved in camera-type eye formation

Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles.


recombinational interstrand cross-link repair

Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.


intracellular bile acid receptor signaling pathway

The series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


substrate-independent telencephalic tangential migration

The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact.


histidine ammonia-lyase activity

Catalysis of the reaction: L-histidine = urocanate + NH3.


regulation of fibronectin-dependent thymocyte migration

Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration.


phthalate 3,4-cis-dihydrodiol dehydrogenase activity

Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+.


flocculation

The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs.


Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate.


ferric-vibriobactin transmembrane transporter activity

Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other.


regulation of establishment of planar polarity involved in neural tube closure

Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


regulation of C-C chemokine receptor CCR7 signaling pathway

Any process that modulates the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway.


regulation of cerebellar neuron development

Any process that modulates the frequency, rate or extent of cerebellar neuron development.


negative regulation of cell adhesion molecule production

Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.


neuron fate specification

The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


far-red light signaling pathway

The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.


amacrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.


(-)-endo-fenchol synthase activity

Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate.


nitric oxide production involved in inflammatory response

The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.


Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone.


primary oocyte stage

The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells.


maintenance of protein location in membrane

Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere.


glycerate transmembrane transporter activity

Enables the transfer of glycerate from one side of a membrane to the other.


positive regulation of short-term neuronal synaptic plasticity

A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.


SCF complex disassembly in response to cadmium stress

The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress.


N-terminal protein amino acid methylation

The methylation of the N-terminal amino acid of a protein.


negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation.


positive regulation of synaptic transmission, cholinergic

Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.


penicillinase activity

Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin.


regulation of eye photoreceptor cell development

Any process that modulates the frequency, rate or extent of eye photoreceptor development.


Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate.


cortisol binding

Binding to cortisol.


positive regulation of smooth muscle cell migration

Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.


The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


positive regulation of response to DNA damage checkpoint signaling

Any process that activates or increases the frequency, rate or extent of response to DNA damage checkpoint signaling.


conversion of aspartyl-tRNA to asparaginyl-tRNA

The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA.


Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP.


protein desuccinylation

The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein.


positive regulation of sporulation resulting in formation of a cellular spore

Any process that activates or increases the frequency, rate or extent of sporulation.


negative regulation of muscle organ development

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.


response to mitotic spindle checkpoint signaling

A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling.


aerobic respiration, using arsenite as electron donor

The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems.


The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase.


transcription by RNA polymerase IV

The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter.


Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate.


positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.


regulation of single-species biofilm formation on inanimate substrate

Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate.


pyridoxine 4-oxidase activity

Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2.


NADPH pyrophosphatase activity

Catalysis of the reaction: NADPH + H2O = NMNH + ADP.


D-serine biosynthetic process

The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine.


oocyte dorsal/ventral axis specification

The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.


symbiont-mediated disruption of host cell PML body

The process in which an organism effects a change that impairs the structure or function of the host PML body. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction.


interleukin-13 receptor activity

Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


phosphoenolpyruvate transmembrane transporter activity

Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other.


cap-independent translational initiation of linear mRNA

The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation.


high-affinity L-glutamate transmembrane transporter activity

Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


borate efflux transmembrane transporter activity

Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane.


paspalinine synthase activity

Catalysis of the reaction: paspalicine + O2 + NADPH + H+ = paspalinine + NADP + H2O.


Catalysis of the reaction: nuatigenin + UDP-D-glucose = H+ + nuatigenin 3-beta-D-glucopyranoside + UDP.


intracellular monoatomic anion homeostasis

A homeostatic process involved in the maintenance of a steady state level of monoatomic anions within a cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom.


adipate-CoA ligase activity

Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-.


respiratory system process

A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.


Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+.


hydroquinone binding

Binding to hydroquinone.


galactonate dehydratase activity

Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O.


DNA/RNA hybrid binding

Binding to a RNA/DNA hybrid.


stamen filament development

The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen.


cysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid.


negative regulation of beta-galactosidase activity

Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity.


Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H+ = 2-methylbutanal + CO2.


linoleate 9S-lipoxygenase activity

Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.


maintenance of protein location in mast cell secretory granule

A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere.


positive regulation of granulocyte differentiation

Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.


(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity

Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.


copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide

The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide.


response to interleukin-18

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus.


mannosyl diphosphorylinositol ceramide metabolic process

The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative.


C-C chemokine receptor CCR2 signaling pathway

The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.


nitrotoluene catabolic process

The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached.


cellular response to indolebutyric acid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus.


regulation of cell communication by chemical coupling

Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels.


photosynthesis, light reaction

The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I.


radial glia guided migration of Purkinje cell

The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.


positive regulation of endoplasmic reticulum unfolded protein response

Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation.


endocannabinoid signaling pathway

The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol.


phenylalanine 2-monooxygenase activity

Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O.


negative regulation of basophil differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation.


cellular response to cAMP

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.


regulation of cyclodextrin catabolic process

Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process.


7,8-dihydroxy benzo(a)pyrene dioxygenase activity

Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate.


mammary gland involution

The tissue remodeling that removes differentiated mammary epithelia during weaning.


embryonic heart tube left/right pattern formation

The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place.


Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1.


EGF-domain serine xylosyltransferase activity

Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine.


Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate.


regulation of neuronal synaptic plasticity in response to neurotrophin

The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


negative regulation of forward locomotion

Any process that stops, prevents or reduces the frequency, rate or extent of forward locomotion.


calcium ion binding involved in regulation of cytosolic calcium ion concentration

The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations.


starch granule initiation

The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts.


pentose catabolic process to butan-1-ol

The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol.


UDP-L-arabinose metabolic process

The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate.


18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity

Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.


glutaminyl-tRNAGln biosynthesis via transamidation

A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase.


peptidyl-aspartic acid carboxylation

The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid.


retina blood vessel maintenance

A retina homeostatic process preventing the degeneration of a retina blood vessel.


response to catecholamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.


Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine.


cellular response to maltose stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus.


regulation of brood size

Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time.


(R)-mevalonic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of (R)-mevalonic acid.


delta6-acyl-lipid desaturase activity

Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O.


response to monoamine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.


lactate oxidation

The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons.


protein deubiquitination involved in ubiquitin-dependent protein catabolic process

The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism.


establishment of centrosome localization

The directed movement of the centrosome to a specific location.


The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydromethanopterin.


histone H3K122 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122).


regulation of CD4-positive, alpha-beta T cell proliferation

Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.


L-phenylalanine biosynthetic process

The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.


holocytochrome-c synthase activity

Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.


negative regulation of fat cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process.


positive regulation of glial cell migration

Any process that activates or increases the frequency, rate or extent of glial cell migration.


dihydride TNP tautomerase activity

Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form).


methylglyoxal catabolic process

The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.


regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.


positive regulation of macrophage derived foam cell differentiation

Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


cystathionine beta-synthase activity

Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.


ABC-type bacteriocin transporter activity

Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate.


retrograde trans-synaptic signaling by soluble gas

Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand.


genitalia morphogenesis

The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.


dGTP binding

Binding to dGTP, deoxyguanosine triphosphate.


modulation of nutrient release by symbiont

Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


protein unfolding

The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.


tetrahymanol cyclase activity

Catalysis of the reaction: squalene = tetrahymanol.


structural constituent of vitelline membrane

The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster.


regulation of vascular wound healing

Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


positive regulation of cellular extravasation

Any process that activates or increases the frequency, rate, or extent of cellular extravasation.


The chemical reactions and pathways involving a tetrahydromethanopterin.


ductus arteriosus closure

The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.


negative regulation of response to drug

Any process that stops, prevents or reduces the frequency, rate or extent of response to drug.


renal tubular secretion

The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.


ureidosuccinase activity

Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4.


long-chain fatty acid omega-1 hydroxylase activity

Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase.


Catalysis of the reaction: caffeoylshikimate + coenzyme A = caffeoyl-CoA + shikimate.


inflorescence phyllotactic patterning

The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem.


ribitol 2-dehydrogenase activity

Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH.


basal dendrite arborization

The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches.


high-affinity thiamine:proton symporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


xanthosine transmembrane transporter activity

Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other.


farnesyl diphosphate biosynthetic process, mevalonate pathway

The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.


protease localization to T cell secretory granule

Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell.


depsipeptide metabolic process

The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively.


protein linear deubiquitination

A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein.


inner ear receptor cell stereocilium organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.


metanephric renal vesicle morphogenesis

The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells.


myoblast fusion

A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


stress granule assembly

The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity

Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


response to flavonoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus.


limb basal epidermal cell fate specification

The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


cell-cell signaling involved in mesonephros development

Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ.


poly(C) RNA binding

Binding to a sequence of cytosine residues in an RNA molecule.


Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol.


negative regulation of CD4-positive, alpha-beta T cell activation

Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.


negative regulation of peptide antigen transport

Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport.


cardiac neural crest cell development involved in outflow tract morphogenesis

The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.


L-arabinokinase activity

Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H+.


response to ketone

A response that results in a state of tolerance to ketone.


Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+.


negative regulation of type B pancreatic cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.


regulation of inflammatory response to wounding

Any process that modulates the frequency, rate or extent of the inflammatory response to wounding.


prostaglandin J receptor activity

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.


growth hormone secretagogue receptor activity

Combining with ghrelin to initiate a change in cell activity.


myoblast fate commitment involved in skeletal muscle regeneration

The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


cellular response to nitrate

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus.


regulation of striated muscle tissue development

Any process that modulates the frequency, rate or extent of striated muscle development.


positive regulation of maternal process involved in parturition

Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition.


membrane curvature sensor activity

Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.


oleoyl-CoA ligase activity

Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA.


The chemical reactions and pathways resulting in the breakdown of 2-methylbut-2-enoyl-CoA(4-).


nitrite transmembrane transporter activity

Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other.


trans-zeatin-O-glucoside UDP glycosyltransferase activity

Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP.


JUN phosphorylation

The process of introducing a phosphate group into a JUN protein.


ether metabolic process

The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds.


enteroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.


brain morphogenesis

The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).


4,9-DSHA hydrolase activity

Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+.


Atg12 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond.


GDP-mannose metabolic process

The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.


DNA ligation involved in DNA recombination

The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination.


regulation of compound eye pigmentation

Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye.


positive regulation of toll-like receptor signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.


quercetin biosynthetic process

The chemical reactions and pathways resulting in the formation of quercetin.


negative regulation of ephrin receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of ephrin receptor signaling pathway.


metanephric glomerular epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells.


methionine synthase activity

Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.


fungal-type cell wall organization or biogenesis

A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall.


lens fiber cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.


positive regulation of transmission of nerve impulse

Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in).


DNA replication, Okazaki fragment processing

The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand.


ciliary transition fiber assembly

The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber.


nucleoside oxidase activity

Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O.


long descending thin limb bend development

The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment.


adult heart development

The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.


metanephric glomerulus vasculature morphogenesis

The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.


specification of plant organ position

The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ.


piperitol synthase activity

Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 = (+)-piperitol + NADP + 2 H2O.


regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway

Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.


L-kynurenine metabolic process

The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).


peptidyl-dipeptidase activity

Catalysis of the release of C-terminal dipeptides from a polypeptide chain.


Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine.


collagen-activated signaling pathway

The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


2,4-dichlorobenzoate metabolic process

The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs).


mycolate cell wall layer assembly

The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer.


positive regulation of lens fiber cell differentiation

Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation.


haustorium neck formation

The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction.


response to methotrexate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


response to olanzapine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus.


negative regulation of lipid localization

Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization.


regulation of pro-T cell differentiation

Any process that modulates the frequency, rate or extent of pro-T cell differentiation.


high-affinity basic amino acid transmembrane transporter activity

Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


sarcosine reductase activity

Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin.


cord factor receptor activity

Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity.


regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.


nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide

The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide.


ectodermal placode formation

The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.


PLC activating G protein-coupled glutamate receptor activity

A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.


RNA-templated transcription

The synthesis of an RNA transcript from an RNA template.


mitotic anaphase

The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.


tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity

Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives.


cellular response to tetracycline

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus.


Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate.


negative regulation of killing of cells of another organism

Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism.


vanillate amino acid synthetase activity

Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate.


peristalsis

A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.


galacturonate metabolic process

The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.


D-arginine metabolic process

The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.


L-glucuronate reductase activity

Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH.


acetaldehyde dehydrogenase (acetylating) activity

Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.


acetyl-CoA biosynthetic process from ethanol

The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde.


P-TEFb-cap methyltransferase complex localization

Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location.


cellular response to mercaptoethanol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus.


positive regulation of cellobiose metabolic process

Any process that activates or increases the frequency, rate or extent of cellobiose metabolic process.


Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine.


vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles.


acireductone dioxygenase [iron(II)-requiring] activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in).


dimethyl sulfoxide reductase activity

Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O.


sesquiterpene synthase activity

Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons.


plant parenchymal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure.


regulation of endodermal cell differentiation

Any process that modulates the frequency, rate or extent of endodermal cell differentiation.


regulation of cilium movement

Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.


detection of biotic stimulus

The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.


establishment of blood-retinal barrier

Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type.


Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+.


Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP.


negative regulation of chemotaxis to arachidonic acid

Any process that stops, prevents or reduces the frequency, rate or extent of chemotaxis to arachidonic acid.


renal albumin absorption

A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron.


3-cyano-L-alanine metabolic process

The chemical reactions and pathways involving 3-cyano-L-alanine.


Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+.


Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.


polychlorinated biphenyl binding

Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings.


positive regulation of sporangium germination

Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination.


IAA-Phe conjugate hydrolase activity

Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine.


positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus

Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in).


sulfur compound binding

Binding to a sulfur compound.


positive regulation of glucocorticoid secretion

Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion.


melanin metabolic process

The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.


pyrimidine deoxyribonucleoside salvage

Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis.


response to dithiothreitol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.


lithium ion binding

Binding to a lithium ion (Li+).


branched-chain amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.


HLA-C specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte.


negative regulation of insulin-like growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.


berbamunine biosynthetic process

The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid.


alcohol O-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.


negative regulation of lymphocyte migration

Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.


Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+.


Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate.


striated muscle cell proliferation

The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.


P-TEFb complex binding

Binding to a P-TEFb complex.