haptoglobin binding

Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.


type 6 serotonin receptor binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to a type 6 serotonin receptor.


C3HC4-type RING finger domain binding

Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.


type 2B serotonin receptor binding

Binding to a type 2B serotonin receptor.


interleukin-9 binding

Binding to interleukin-9.


CD4 receptor binding

Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages.


type 2 metabotropic GABA receptor binding

Binding to a type 2 metabotropic GABA receptor.


MIT domain binding

Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.


protein phosphatase 5 binding

Binding to protein phosphatase 5.


type 1 cannabinoid receptor binding

Binding to a type 1 cannabinoid receptor.


GAF domain binding

Binding to a GAF protein domain.


very-low-density lipoprotein particle binding

Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.


protein phosphatase 1 binding

Binding to a protein phosphatase 1.


14-3-3 protein binding

Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.


syndecan binding

Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.


protein binding involved in heterotypic cell-cell adhesion

Binding to a protein or protein complex contributing to the adhesion of two different types of cells.


sevenless binding

Binding to a sevenless (sev) protein, a receptor tyrosine kinase.


MHC class Ib protein binding

Binding to a major histocompatibility complex class Ib molecules.


type 1 fibroblast growth factor receptor binding

Binding to a type 1 fibroblast growth factor receptor (FGFR1).


Edg-2 lysophosphatidic acid receptor binding

Binding to an Edg-2 lysophosphatidic acid receptor.


type-I cohesin domain binding

Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain.


complement component C5a binding

Binding to a C5a product of the complement cascade.


type 2 somatostatin receptor binding

Binding to a type 2 somatostatin receptor.


substance P receptor binding

Binding to a substance P receptor.


G-protein alpha-subunit binding

Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.


type A cholecystokinin receptor binding

Binding to a type A cholecystokinin receptor.


dynein intermediate chain binding

Binding to an intermediate chain of the dynein complex.


myosin II heavy chain binding

Binding to a heavy chain of a myosin II complex.


type 1 angiotensin receptor binding

Binding to a type 1 angiotensin receptor.


LIM domain binding

Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.


amylin binding

Binding to amylin.


receptor-receptor interaction

The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.


Toll-like receptor 2 binding

Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.


troponin T binding

Binding to troponin T, the tropomyosin-binding subunit of the troponin complex.


complement component iC3b binding

Binding to a iC3b product of the complement cascade.


type 2 neuropeptide Y receptor binding

Binding to a type 2 neuropeptide Y receptor.


D4 dopamine receptor binding

Binding to a D4 dopamine receptor.


CARD domain binding

Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.


apolipoprotein A-I binding

Binding to apolipoprotein A-I.


alpha-2B adrenergic receptor binding

Binding to an alpha-2B adrenergic receptor.


TFIIE-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


preprotein binding

Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.


interleukin-21 binding

Binding to interleukin-21.


interleukin-12 binding

Binding to interleukin-12.


hemoglobin beta binding

Binding to a hemoglobin beta chain.


proteinase activated receptor binding

Binding to a proteinase activated receptor.


SOCS family protein binding

Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions.


MHC class Ib protein binding, via antigen binding groove

Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove.


GTP cyclohydrolase binding

Binding to a GTP cyclohydrolase.


P2Y10 nucleotide receptor binding

Binding to a P2Y10 nucleotide receptor.


adiponectin binding

Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.


co-receptor binding

Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.


K48-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.


P2Y8 nucleotide receptor binding

Binding to a P2Y8 nucleotide receptor.


complement component C4b binding

Binding to a C4b product of the classical complement cascade.


thromboxane A2 receptor binding

Binding to a thromboxane A2 receptor.


ephrin receptor binding

Binding to an ephrin receptor.


G protein-coupled glutamate receptor binding

Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor).


type-II cohesin domain binding

Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain.


type 1 somatostatin receptor binding

Binding to a type 1 somatostatin receptor.


corticotropin-releasing hormone receptor binding

Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


diacyl lipopeptide binding

Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups.


G protein-coupled histamine receptor binding

Binding to a G protein-coupled (metabotropic) histamine receptor.


ErbB-3 class receptor binding

Binding to the protein-tyrosine kinase receptor ErbB-3/HER3.


myosin I tail binding

Binding to the tail region of a myosin I heavy chain.


myosin XI tail binding

Binding to the tail region of a myosin XI heavy chain.


TIR domain binding

Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.


phospholipase binding

Binding to a phospholipase.


kringle domain binding

Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors.


interleukin-26 binding

Binding to interleukin-26.


semaphorin receptor binding

Binding to a semaphorin receptor.


beta-endorphin receptor binding

Binding to a beta-endorphin receptor.


interleukin-11 binding

Binding to interleukin-11.


RNA polymerase III general transcription initiation factor binding

Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III.


myosin II binding

Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.


type 1B melatonin receptor binding

Binding to a type 1B melatonin receptor.


type B gastrin/cholecystokinin receptor binding

Binding to a type B gastrin/cholecystokinin receptor.


glutamate receptor binding

Binding to a glutamate receptor.


hexon binding

Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus.


P2Y6 nucleotide receptor binding

Binding to a P2Y6 nucleotide receptor.


BMP receptor binding

Binding to a BMP receptor.


endoplasmic reticulum signal peptide binding

Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.


type 1 cysteinyl leukotriene receptor binding

Binding to a type 1 cysteinyl leukotriene receptor.


G protein-coupled acetylcholine receptor binding

Binding to a G protein-coupled acetylcholine receptor.


denatured protein binding

Binding to a denatured protein.


urotensin receptor binding

Binding to a urotensin receptor.


eukaryotic initiation factor 4E binding

Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.


p53 binding

Binding to one of the p53 family of proteins.


TFIIA-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.


interleukin-23 binding

Binding to interleukin-23.


chemokine (C-C motif) ligand 21 binding

Binding to chemokine (C-C motif) ligand 21.


neuromedin K receptor binding

Binding to a neuromedin K receptor.


glycosylated region protein binding

Binding to a glycosylated region of a protein.


alpha-1A adrenergic receptor binding

Binding to an alpha-1A adrenergic receptor.


beta-3 adrenergic receptor binding

Binding to a beta-3 adrenergic receptor.


ganglioside binding

Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues.


acrosin binding

Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities.


V2 vasopressin receptor binding

Binding to a V2 vasopressin receptor.


H3 histamine receptor binding

Binding to a H3 histamine receptor.


cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.


type 4 metabotropic glutamate receptor binding

Binding to a type 4 metabotropic glutamate receptor.


MHC class I protein binding, via antigen binding groove

Binding to a major histocompatibility complex class I molecules via the antigen binding groove.


type I interferon binding

Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.


myosin I heavy chain binding

Binding to a heavy chain of a myosin I complex.


alpha-catenin binding

Binding to catenin complex alpha subunit.


type 1 melanocortin receptor binding

Binding to a type 1 melanocortin receptor.


hemoglobin binding

Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


troponin I binding

Binding to troponin I, the inhibitory subunit of the troponin complex.


adrenergic receptor binding

Binding to an adrenergic receptor.


zf-TRAF domain binding

Binding to a TRAF-type zinc finger domain of a protein.


lipase binding

Binding to a lipase.


G-protein gamma-subunit binding

Binding to a G-protein gamma subunit.


interferon binding

Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.


cytoskeletal regulatory protein binding

Binding to a protein involved in modulating the reorganization of the cytoskeleton.


Edg-6 sphingosine 1-phosphate receptor binding

Binding to an Edg-6 sphingosine 1-phosphate receptor.


prostanoid receptor binding

Binding to a prostanoid receptor.


interleukin-22 binding

Binding to interleukin-22.


plastid single-subunit type RNA polymerase binding

Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


insulin-like growth factor I binding

Binding to insulin-like growth factor I.


TFIIIB-class transcription factor complex binding

Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


TFIIIC-class transcription factor complex binding

Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


C2 domain binding

Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes.


cholecystokinin receptor binding

Binding to a cholecystokinin receptor.


talin binding

Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types.


type 2 metabotropic glutamate receptor binding

Binding to a type 2 metabotropic glutamate receptor.


interleukin-20 binding

Binding to interleukin-20.


low-density lipoprotein particle receptor binding

Binding to a low-density lipoprotein receptor.


TAP1 binding

Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein.


prolactin-releasing peptide receptor binding

Binding to a prolactin-releasing peptide receptor.


type I activin receptor binding

Binding to a type I activin receptor.


glycosylation-dependent protein binding

Binding to a protein upon glycosylation of the target protein.


BH1 domain binding

Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.


EP3 subtype prostaglandin E2 receptor binding

Binding to an EP3 subtype prostaglandin E2 receptor.


type III interferon binding

Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far.


ATPase binding

Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.


protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


peptidyl-proline 4-dioxygenase binding

Binding to a peptidyl-proline 4-dioxygenase.


Edg-4 lysophosphatidic acid receptor binding

Binding to an Edg-4 lysophosphatidic acid receptor.


mitochondrial single-subunit type RNA polymerase binding

Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


chemokine (C-C motif) ligand 7 binding

Binding to chemokine (C-C motif) ligand 7.


RNA polymerase II complex recruiting activity

Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.


protein phosphatase 2A binding

Binding to protein phosphatase 2A.


high-density lipoprotein particle receptor binding

Binding to a high-density lipoprotein receptor.


CH domain binding

Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins.


cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.


vacuolar sorting signal binding

Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole.


interleukin-19 binding

Binding to interleukin-19.


C-X3-C chemokine binding

Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.


collectin binding

Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.


type 1 metabotropic glutamate receptor binding

Binding to a type 1 metabotropic glutamate receptor.


secretin receptor binding

Binding to a secretin receptor.


RBL family protein binding

Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose.


PDZ domain binding

Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.


opioid receptor binding

Binding to an opioid receptor.


calcitonin binding

Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.


cyclosporin A binding

Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.


neuromedin U receptor binding

Binding to one or more specific sites on a neuromedin U receptor.


K6-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein.


eukaryotic initiation factor 4G binding

Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.


interleukin-18 binding

Binding to interleukin-18.


P2Y11 nucleotide receptor binding

Binding to a P2Y11 nucleotide receptor.


MDA-5 binding

Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.


cargo receptor ligand activity

The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.


Binding to a protein upon phosphorylation of the target protein.


type 1 metabotropic GABA receptor binding

Binding to a type 1 metabotropic GABA receptor.


type 2C serotonin receptor binding

Binding to a type 2C serotonin receptor.


virion binding

Binding to a virion, either by binding to components of the capsid or the viral envelope.


melanin-concentrating hormone receptor binding

Binding to a melanin-concentrating hormone receptor.


Edg-1 sphingosine 1-phosphate receptor binding

Binding to an Edg-1 sphingosine 1-phosphate receptor.


K11-linked polyubiquitin modification-dependent protein binding

Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein.


type 5B serotonin receptor binding

Binding to a type 5B serotonin receptor.


neuromedin U binding

Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses.


apolipoprotein binding

Binding to an apolipoprotein, the protein component of a lipoprotein complex.


gonadotropin-releasing hormone receptor binding

Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


type 1 neuromedin U receptor binding

Binding to a type 1 neuromedin U receptor.


platelet activating factor receptor binding

Binding to a platelet activating factor receptor.


nuclear vitamin D receptor binding

Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.


parathyroid hormone receptor binding

Binding to a parathyroid hormone receptor.


death effector domain binding

Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).


nuclear mineralocorticoid receptor binding

Binding to a nuclear mineralocorticoid receptor.


V1A vasopressin receptor binding

Binding to a V1A vasopressin receptor.


transcription corepressor binding

Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.


FFAT motif binding

Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.


virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.


bombesin receptor binding

Binding to a bombesin receptor.


angiostatin binding

Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis.


macrophage migration inhibitory factor binding

Binding to the cytokine, macrophage migration inhibitory factor.


exogenous protein binding

Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein.


granulocyte macrophage colony-stimulating factor complex binding

Binding to a granulocyte macrophage colony-stimulating factor complex.


corticotropin-releasing hormone binding

Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


nitric-oxide synthase binding

Binding to nitric-oxide synthase.


pentraxin binding

Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.


A2B adenosine receptor binding

Binding to an A2B adenosine receptor.


myosin V binding

Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.


cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication

Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.


bacterial-type RNA polymerase core enzyme binding

Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.


high molecular weight B cell growth factor receptor binding

Binding to a high molecular weight B cell growth factor receptor.


TFIIH-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


STAT family protein binding

Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.


Hsp27 protein binding

Binding to Hsp27 proteins, a lightweight heat shock protein.


BIR domain binding

Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain.


titin binding

Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.


connexin binding

Binding to a connexin, any of a group of related proteins that assemble to form gap junctions.


spectrin binding

Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.


RNA polymerase II C-terminal domain binding

Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function.


interleukin-12 alpha subunit binding

Binding to the alpha subunit of interleukin-12.


prostacyclin receptor binding

Binding to a prostacyclin receptor.


chloroplast targeting sequence binding

Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.


nuclear retinoid X receptor binding

Binding to a nuclear retinoid X receptor.


interleukin-13 binding

Binding to interleukin-13.


nodal binding

Binding to a nodal protein, a member of the transforming growth factor-beta superfamily.


cell adhesion receptor activity

The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins.


Fc-gamma receptor I complex binding

Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.


transferrin receptor binding

Binding to a transferrin receptor.


EP2 subtype prostaglandin E2 receptor binding

Binding to an EP2 subtype prostaglandin E2 receptor.


somatostatin binding

Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin.


chondroitin sulfate proteoglycan binding

Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.


fMet-Leu-Phe receptor binding

Binding to a fMet-Leu-Phe receptor.


MHC class II protein binding, via lateral surface

Binding to the lateral surface of major histocompatibility complex class II molecules.


scavenger receptor binding

Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.


type 6 metabotropic glutamate receptor binding

Binding to a type 6 metabotropic glutamate receptor.


D3 dopamine receptor binding

Binding to a D3 dopamine receptor.


laminin-1 binding

Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.


type 7 metabotropic glutamate receptor binding

Binding to a type 7 metabotropic glutamate receptor.


DH domain binding

Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.


alpha-2C adrenergic receptor binding

Binding to an alpha-2C adrenergic receptor.


CD8 receptor binding

Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.


SUMO binding

Binding to the small ubiquitin-like protein SUMO.


type 1 orexin receptor binding

Binding to a type 1 orexin receptor.


muscle alpha-actinin binding

Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.


tropomyosin binding

Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.


complement component C3d binding

Binding to a C3d product of the complement cascade.


aryl hydrocarbon receptor binding

Binding to an aryl hydrocarbon receptor.


translation elongation factor binding

Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.


protein heterodimerization activity

Binding to a nonidentical protein to form a heterodimer.


single-subunit type RNA polymerase binding

Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


insulin-like growth factor II binding

Binding to insulin-like growth factor II.


interleukin-27 binding

Binding to interleukin-27.


TFIIB-class transcription factor binding

Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


type 1B serotonin receptor binding

Binding to a type 1B serotonin receptor.


tapasin binding

Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules.


opsin binding

Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.


Edg-7 lysophosphatidic acid receptor binding

Binding to an Edg-7 lysophosphatidic acid receptor.


leucine zipper domain binding

Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.


arrestin family protein binding

Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.


lysine-acetylated histone binding

Binding to a histone in which a lysine residue has been modified by acetylation.


patched binding

Binding to a patched (ptc) protein, a receptor for hedgehog proteins.


dynein light chain binding

Binding to a light chain of the dynein complex.


calcium-dependent protein binding

Binding to a protein or protein complex in the presence of calcium.


type 1 neurotensin receptor binding

Binding to a type 1 neurotensin receptor.


myosin tail binding

Binding to the tail region of a myosin heavy chain.


type-III cohesin domain binding

Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain.


nuclear retinoic acid receptor binding

Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.


epidermal growth factor binding

Binding to epidermal growth factor.


endothelial differentiation G protein-coupled receptor binding

Binding to an endothelial differentiation G protein-coupled receptor.


peroxisome membrane class-2 targeting sequence binding

Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner.


penicillin binding

Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.


TFIIIA-class transcription factor binding

Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters.


DNA binding domain binding

Binding to a protein's DNA binding domain (DBD).


neuroligin family protein binding

Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.


ADP-D-ribose modification-dependent protein binding

Binding to a protein upon ADP-ribosylation of the target protein.


ciliary neurotrophic factor binding

Binding to the cytokine ciliary neurotrophic factor.


orexin receptor binding

Binding to an orexin receptor.


zymogen binding

Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.


gamma-catenin binding

Binding to catenin complex gamma subunit.


EP4 subtype prostaglandin E2 receptor binding

Binding to an EP4 subtype prostaglandin E2 receptor.


FYXD domain binding

Binding to a FXYD domain.


calcium-dependent outer dynein arm binding

Binding to an outer dynein arm in the presence of calcium.


interleukin-33 binding

Binding to interleukin-33.


triacyl lipopeptide binding

Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups.


SAM domain binding

Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes.


peroxisome matrix targeting signal-2 binding

Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).


glial cell-derived neurotrophic factor receptor binding

A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


GBD domain binding

Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.


proctolin receptor binding

Binding to a proctolin receptor.


MHC class I protein binding

Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


insulin-like growth factor binding

Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.


T cell receptor binding

Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells.


hepatocyte growth factor binding

Binding to a hepatocyte growth factor.


Tat protein binding

Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.


H9 melatonin receptor binding

Binding to a H9 melatonin receptor.


glucagon receptor binding

Binding to a glucagon receptor.


PH domain binding

Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.


type 1 member 3 taste receptor binding

Binding to a type 1 member 3 taste receptor.


myosin VI light chain binding

Binding to a light chain of a myosin VI complex.


beta-2-microglobulin binding

Binding to beta-2-microglobulin.


endocytic targeting sequence binding

Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits.


MATH domain binding

Binding to a meprin and TRAF homology (MATH) domain.


interleukin-8 binding

Binding to interleukin-8.


intercellular adhesion molecule-3 receptor binding

Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1.


cell adhesive protein binding involved in AV node cell-bundle of His cell communication

Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.


extracellular matrix protein binding

Binding to a protein that is part of an extracellular matrix.


H2 histamine receptor binding

Binding to a H2 histamine receptor.


corazonin receptor binding

Binding to a corazonin receptor.


myosin VI heavy chain binding

Binding to a heavy chain of a myosin VI complex.


MH2 domain binding

Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.


nuclear localization sequence binding

Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.


hedgehog family protein binding

Binding to a member of the hedgehog protein family, signaling proteins involved in development.


RIP homotypic interaction motif binding

Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases.


interleukin-10 binding

Binding to interleukin-10.


ErbB-4 class receptor binding

Binding to the protein-tyrosine kinase receptor ErbB-4/HER4.


nuclear glucocorticoid receptor binding

Binding to a nuclear glucocorticoid receptor.


V1B vasopressin receptor binding

Binding to a V1B vasopressin receptor.


cAMP response element binding protein binding

Binding to a cAMP response element binding protein (a CREB protein).


filamin binding

Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


MADS box domain binding

Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs.


type 1 member 1 taste receptor binding

Binding to a type 1 member 1 taste receptor.


low molecular weight kininogen binding

Binding to a kininogen of low molecular mass.


peptide hormone receptor binding

Binding to a receptor for a peptide hormone.


type 7 serotonin receptor binding

Binding to a type 7 serotonin receptor.


proteoglycan binding

Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


neuropeptide F receptor binding

Binding to a neuropeptide F receptor.


acetylation-dependent protein binding

Binding to a protein upon acetylation of the target protein.


beta-2 adrenergic receptor binding

Binding to a beta-2 adrenergic receptor.


CRD domain binding

Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins.


death domain binding

Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.


importin-alpha family protein binding

Binding to a member of the importin-alpha family.


neurotrophin binding

Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.


nuclear cortisol receptor binding

Binding to a nuclear cortisol receptor.


chemokine (C-C motif) ligand 12 binding

Binding to chemokine (C-C motif) ligand 12.


type 4 neuropeptide Y receptor binding

Binding to a type 4 neuropeptide Y receptor.


linear polyubiquitin binding

Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next.


actinin binding

Binding to actinin, any member of a family of proteins that crosslink F-actin.


prostaglandin F2-alpha receptor binding

Binding to a prostaglandin F2-alpha receptor.


farnesylated protein binding

Binding to a farnesylated protein.


pituitary adenylate cyclase-activating polypeptide receptor binding

Binding to a pituitary adenylate cyclase-activating polypeptide receptor.


gastric inhibitory polypeptide receptor binding

Binding to a gastric inhibitory polypeptide receptor.


Rho GDP-dissociation inhibitor binding

Binding to a Rho GDP-dissociation inhibitor protein.


myosin II head/neck binding

Binding to the head/neck region of a myosin II heavy chain.


ubiquitin-specific protease binding

Binding to a ubiquitin-specific protease.


type-II dockerin domain binding

Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain.


RAGE receptor binding

Binding to a RAGE receptor, the receptor for advanced glycation end-products.


interleukin-17 binding

Binding to a member of the interleukin-17 family of cytokines.


laminin binding involved in cell-matrix adhesion

Any laminin protein binding that occurs as part of cell-matrix adhesion.


olfactory receptor binding

Binding to an olfactory receptor.


orexigenic neuropeptide QRFP receptor binding

Binding to an orexigenic neuropeptide QRFP receptor.


ciliary targeting signal binding

Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane.


thioesterase binding

Binding to a thioesterase.


gonadotropin-releasing hormone binding

Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


A3 adenosine receptor binding

Binding to an A3 adenosine receptor.


poly-ADP-D-ribose modification-dependent protein binding

Binding to a protein upon poly-ADP-ribosylation of the target protein.


angiotensin receptor binding

Binding to an angiotensin receptor.


subtype 3 bombesin receptor binding

Binding to a subtype 3 bombesin receptor.


delta-catenin binding

Binding to the delta subunit of the catenin complex.


DNA polymerase binding

Binding to a DNA polymerase.


immunoglobulin receptor binding

Binding to one or more specific sites on an immunoglobulin receptor molecule.


thioglucosidase binding

Binding to a thioglucosidase enzyme.


Krueppel-associated box domain binding

Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.


Rel homology domain binding

Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT.


urea binding

Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2.


endothelin B receptor binding

Binding to an endothelin B receptor.


DDEL sequence binding

Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


oxytocin receptor binding

Binding to an oxytocin receptor.


type 3 melanocortin receptor binding

Binding to a type 3 melanocortin receptor.


insulin receptor substrate binding

Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.


type 4 melanocortin receptor binding

Binding to a type 4 melanocortin receptor.


kisspeptin receptor binding

Binding to a kisspeptin receptor.


type 1D serotonin receptor binding

Binding to a type 1D serotonin receptor.


caspase binding

Binding to a caspase family protein.


H3K27me3 modified histone binding

Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation.


kininogen binding

Binding to a kininogen, a kinin precursor.


high mobility group box 1 binding

Binding to high mobility group box 1 (HMBGB1).


adrenomedullin receptor binding

Binding to an adrenomedullin receptor.


type 1 melanin-concentrating hormone receptor binding

Binding to a type 1 melanin-concentrating hormone receptor.


LEM domain binding

Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF).


transcription coregulator binding

Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.


syntaxin-3 binding

Binding to a syntaxin-3 SNAP receptor.


thyrotropin-releasing hormone receptor binding

Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.


S100 protein binding

Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.


CAP-Gly domain binding

Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets.


histone methyltransferase binding

Binding to a histone methyltransferase enzyme.


vasopressin receptor binding

Binding to a vasopressin receptor.


MHC class I protein binding, via lateral surface

Binding to a major histocompatibility complex class I molecules via the lateral surface.


EGF repeat binding

Binding to Epidermal Growth Factor (EGF) repeats.


type 2 vasoactive intestinal polypeptide receptor binding

Binding to a type 2 vasoactive intestinal polypeptide receptor.


protein phosphatase 2B binding

Binding to a protein phosphatase 2B.


apolipoprotein A-I receptor binding

Binding to an apolipoprotein A-I receptor.


mu-type opioid receptor binding

Binding to a mu-type opioid receptor.


type 5 metabotropic glutamate receptor binding

Binding to a type 5 metabotropic glutamate receptor.


insulin receptor binding

Binding to an insulin receptor.


interleukin-25 binding

Binding to interleukin-25.


cannabinoid receptor binding

Binding to a cannabinoid receptor.


cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication

Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells.


ankyrin binding

Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.


P2Y2 nucleotide receptor binding

Binding to a P2Y2 nucleotide receptor.


type 3 galanin receptor binding

Binding to a type 3 galanin receptor.


SMC family protein binding

Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization.


titin Z domain binding

Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.


AF-1 domain binding

Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.


type 5 somatostatin receptor binding

Binding to a type 5 somatostatin receptor.


SUMO polymer binding

Binding to a polymer of the small ubiquitin-like protein SUMO.


ubiquitin conjugating enzyme binding

Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.


CD70 receptor binding

Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells.


C2H2 zinc finger domain binding

Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.


nuclear thyroid hormone receptor binding

Binding to a nuclear thyroid hormone receptor.


scaffold protein binding

Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.


myosin VI binding

Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


imaginal disc growth factor receptor binding

Binding to an imaginal disc growth factor receptor.


proline-rich region binding

Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.


oligopeptide binding

Binding to an oligopeptide.


neuregulin binding

Binding to a neuregulin, a member of the EGF family of growth factors.


neuropeptide receptor binding

Binding to a neuropeptide receptor.


clathrin heavy chain binding

Binding to a clathrin heavy chain.


galanin receptor binding

Binding to a galanin receptor.


ubiquitin modification-dependent histone binding

Binding to a histone protein in which a residue has been modified by ubiquitination.


laminin binding

Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells.


bradykinin receptor binding

Binding to a bradykinin receptor.


smoothened binding

Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.


Toll binding

Binding to a Toll protein, a transmembrane receptor.


Pyrin domain binding

Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.


chemokine (C-C motif) ligand 19 binding

Binding to chemokine (C-C motif) ligand 19.


corticotropin hormone receptor binding

Binding to a corticotropin hormone receptor.


POU domain binding

Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.


Notch binding

Binding to a Notch (N) protein, a surface receptor.


NFAT protein binding

Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.


myosin light chain binding

Binding to a light chain of a myosin complex.


C5a anaphylatoxin chemotactic receptor binding

Binding to a C5a anaphylatoxin chemotactic receptor.


telethonin binding

Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.


Edg-3 sphingosine 1-phosphate receptor binding

Binding to an Edg-3 sphingosine 1-phosphate receptor.


TFIIF-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


GTP-dependent protein binding

Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.


RNA polymerase I general transcription initiation factor binding

Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I.


type 8 metabotropic glutamate receptor binding

Binding to a type 8 metabotropic glutamate receptor.


eukaryotic initiation factor eIF2 binding

Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.


complement component C3b binding

Binding to a C3b product of the complement cascade.


ubiquitin-like protein binding

Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.


type 3 proteinase activated receptor binding

Binding to a type 3 proteinase activated receptor.


frizzled binding

Binding to a frizzled (fz) receptor.


follicle-stimulating hormone receptor binding

Binding to a follicle-stimulating hormone receptor.


H4 histamine receptor binding

Binding to a H4 histamine receptor.


apelin receptor binding

Binding to an apelin receptor.


ceramide binding

Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes.


type 5 neuropeptide Y receptor binding

Binding to a type 5 neuropeptide Y receptor.


growth hormone-releasing hormone receptor binding

Binding to a growth hormone-releasing hormone receptor.


RIG-I binding

Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.


nuclear progesterone receptor binding

Binding to a nuclear progesterone receptor.


C5L2 anaphylatoxin chemotactic receptor binding

Binding to a C5L2 anaphylatoxin chemotactic receptor.


phosphorylated histone binding

Binding to a histone in which a residue has been modified by phosphorylation.


protein domain specific binding

Binding to a specific domain of a protein.


troponin C binding

Binding to troponin C, the calcium-binding subunit of the troponin complex.


ErbB-2 class receptor binding

Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.


microtubule lateral binding

Binding to the side of a microtubule.


lipopeptide binding

Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.


HECT domain binding

Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein.


heparan sulfate proteoglycan binding

Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.


phytochrome binding

Binding to a phytochrome.


ATP-dependent protein binding

Binding to a protein or protein complex using energy from ATP hydrolysis.


myosin VI head/neck binding

Binding to the head/neck region of a myosin VI heavy chain.


apolipoprotein receptor binding

Binding to an apolipoprotein receptor.


poly-glutamine tract binding

Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.


interleukin-7 binding

Binding to interleukin-7.


methylation-dependent protein binding

Binding to a protein upon methylation of the target protein.


type 1 member 2 taste receptor binding

Binding to a type 1 member 2 taste receptor.


adenylate cyclase binding

Binding to an adenylate cyclase.


peroxisome matrix targeting signal-1 binding

Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L.


cell adhesion mediator activity

The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.


G-protein beta-subunit binding

Binding to a G-protein beta subunit.


RHG protein domain binding

Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif).


LBD domain binding

Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.


type 2 melanin-concentrating hormone receptor binding

Binding to a type 2 melanin-concentrating hormone receptor.


phosphatidylinositol 3-kinase regulatory subunit binding

Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.


interleukin-12 beta subunit binding

Binding to the beta subunit of interleukin-12.


brain-derived neurotrophic factor binding

Binding to brain-derived neurotrophic factor.


D5 dopamine receptor binding

Binding to a D5 dopamine receptor.


type 2 galanin receptor binding

Binding to a type 2 galanin receptor.


interleukin-3 binding

Binding to interleukin-3.


A1 adenosine receptor binding

Binding to an A1 adenosine receptor.


PTB domain binding

Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain.


chromo shadow domain binding

Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.


very-low-density lipoprotein particle receptor binding

Binding to a very-low-density lipoprotein receptor.


sulfonylurea receptor binding

Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.


peroxisome proliferator activated receptor binding

Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma.


BH domain binding

Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.


FH1 domain binding

Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain.


type 1F serotonin receptor binding

Binding to a type 1F serotonin receptor.


FK506 binding

Binding to a 23-membered macrolide lactone FK506.


FMN-binding domain binding

Binding to the FMN-binding domain of a protein.


type 5 melanocortin receptor binding

Binding to a type 5 melanocortin receptor.


H4K20me3 modified histone binding

Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.


D1 dopamine receptor binding

Binding to a D1 dopamine receptor.


myosin I binding

Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.


C-X-C chemokine binding

Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.


plastid PEP RNA polymerase core enzyme binding

Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit.


P2Y1 nucleotide receptor binding

Binding to a P2Y1 nucleotide receptor.


transmembrane receptor protein serine/threonine kinase binding

Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity.


type 4 serotonin receptor binding

Binding to a type 4 serotonin receptor.


sterol-dependent protein binding

Binding to a protein or protein complex in the presence of sterols.


GDP-dissociation inhibitor binding

Binding to a GDP-dissociation inhibitor protein.


high molecular weight kininogen receptor binding

Binding to a high molecular weight kininogen receptor.


co-SMAD binding

Binding to a common mediator SMAD signaling protein.


MHC class II protein binding

Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


tau protein binding

Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.


TAP2 binding

Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein.


bone sialoprotein binding

Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin.


neuropilin binding

Binding to a member of the neuropilin family.


glucagon family peptide binding

Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP).


motilin receptor binding

Binding to a motilin receptor.


hepatocyte growth factor receptor binding

Binding to an hepatocyte growth factor receptor.


tachykinin receptor binding

Binding to a tachykinin receptor.


phosphopantetheine binding

Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).


AF-2 domain binding

Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.


GTPase binding

Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP.


interleukin-24 binding

Binding to interleukin-24.


endothelin A receptor binding

Binding to an endothelin A receptor.


nerve growth factor binding

Binding to nerve growth factor (NGF).


lamin binding

Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.


neurokinin receptor binding

Binding to a neurokinin receptor.


beta-1 adrenergic receptor binding

Binding to a beta-1 adrenergic receptor.


ghrelin receptor binding

Binding to a ghrelin receptor.


neuropeptide Y receptor binding

Binding to a neuropeptide Y receptor.


delta-type opioid receptor binding

Binding to a delta-type opioid receptor.


myosin II tail binding

Binding to the tail region of a myosin II heavy chain.


type 2A serotonin receptor binding

Binding to a type 2A serotonin receptor.


taste receptor binding

Binding to a taste receptor.


F-bar domain binding

Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins.


interleukin-2 binding

Binding to interleukin-2.


gastrin-releasing peptide receptor binding

Binding to a gastrin-releasing peptide receptor.


neurotensin receptor binding

Binding to a neurotensin receptor.


nociceptin receptor binding

Binding to a nociceptin receptor.


corticotropin-releasing hormone receptor 1 binding

Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.


interleukin-5 binding

Binding to interleukin-5.


type 1 parathyroid hormone receptor binding

Binding to a type 1 parathyroid hormone receptor.


TRAIL binding

Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.


lutropin-choriogonadotropic hormone receptor binding

Binding to a lutropin-choriogonadotropic hormone receptor.


lipoamide binding

Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.


type 1 proteinase activated receptor binding

Binding to a type 1 proteinase activated receptor.


serpin family protein binding

Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors.


dynein heavy chain binding

Binding to a heavy chain of the dynein complex.


adipokinetic hormone receptor binding

Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


ubiquitin-dependent protein binding

Binding to a protein upon ubiquitination of the target protein.


alpha-latrotoxin receptor binding

Binding to an alpha-latrotoxin receptor.


leptin receptor binding

Binding to a leptin receptor.


platelet-derived growth factor receptor binding

Binding to a platelet-derived growth factor receptor.


CD154 receptor binding

Binding to CD154, a receptor found on the surface of some activated lymphocytes.


misfolded protein binding

Binding to a misfolded protein.


deaminase binding

Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3).


dynein light intermediate chain binding

Binding to a light intermediate chain of the dynein complex.


ganglioside GM3 binding

Binding to ganglioside GM3.


torso binding

Binding to a torso (tor) protein, a receptor tyrosine kinase.


type 2 orexin receptor binding

Binding to a type 2 orexin receptor.


BH4 domain binding

Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.


B2 bradykinin receptor binding

Binding to a B2 bradykinin receptor.


syntaxin-1 binding

Binding to a syntaxin-1 SNAP receptor.


antisigma factor binding

Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator.


kappa-type opioid receptor binding

Binding to a kappa-type opioid receptor.


alpha-2A adrenergic receptor binding

Binding to an alpha-2A adrenergic receptor.


KDEL sequence binding

Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


type 1 neuropeptide Y receptor binding

Binding to a type 1 neuropeptide Y receptor.


peroxisome targeting sequence binding

Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.


H3K9me3 modified histone binding

Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation.


D2 dopamine receptor binding

Binding to a D2 dopamine receptor.


BH3 domain binding

Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.


interleukin-16 binding

Binding to interleukin-16.


type 1A melatonin receptor binding

Binding to a type 1A melatonin receptor.


SET domain binding

Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation.


dynactin binding

Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.


high molecular weight kininogen binding

Binding to a kininogen of high molecular mass.


TIMP family protein binding

Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family.


neuromedin B receptor binding

Binding to a neuromedin B receptor.


transcription coactivator binding

Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.


hemoglobin alpha binding

Binding to a hemoglobin alpha chain.


LRR domain binding

Binding to a LRR domain (leucine rich repeats) of a protein.


TPR domain binding

Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.


type 1 galanin receptor binding

Binding to a type 1 galanin receptor.


cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication

Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells.


RNA polymerase V core binding

Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing.


complement component C3dg binding

Binding to a C3dg product of the complement cascade.


calcitonin receptor binding

Binding to a calcitonin receptor.


small protein activating enzyme binding

Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme.


type 2 cannabinoid receptor binding

Binding to a type 2 cannabinoid receptor.


CNBH domain intrinsic ligand binding

Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide.


WD40-repeat domain binding

Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain.


P2Y4 nucleotide receptor binding

Binding to a P2Y4 nucleotide receptor.


vascular endothelial growth factor binding

Binding to a vascular endothelial growth factor.


bacterial-type RNA polymerase holo enzyme binding

Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.


thyrotropin-releasing hormone binding

Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system.


wishful thinking binding

Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor.


beta-tubulin binding

Binding to the microtubule constituent protein beta-tubulin.


general transcription initiation factor binding

Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation.


Roundabout binding

Binding to Roundabout (ROBO) receptor, a transmembrane receptor.


armadillo repeat domain binding

Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation.


Binding to succinate-semialdehyde dehydrogenase.


type 3 somatostatin receptor binding

Binding to a type 3 somatostatin receptor.


type-III dockerin domain binding

Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain.


Toll-like receptor 4 binding

Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


calcitonin family binding

Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)).


MDM2/MDM4 family protein binding

Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53.


type 5A serotonin receptor binding

Binding to a type 5A serotonin receptor.


RNA polymerase III core binding

Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


BMP binding

Binding to a member of the bone morphogenetic protein (BMP) family.


FBXO family protein binding

Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction.


L27 domain binding

Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.


myosin head/neck binding

Binding to the head/neck region of a myosin heavy chain.


GTPase activating protein binding

Binding to a GTPase activating protein.


F-box domain binding

Binding to an F-box domain of a protein.


natural killer cell lectin-like receptor binding

Binding to a lectin-like natural killer cell receptor.


type 2 fibroblast growth factor receptor binding

Binding to a type 2 fibroblast growth factor receptor (FGFR2).


type 1 vasoactive intestinal polypeptide receptor binding

Binding to a type 1 vasoactive intestinal polypeptide receptor.


DNA topoisomerase binding

Binding to a DNA topoisomerase.


interleukin-35 binding

Binding to interleukin-35.


phosphoprotein binding

Binding to a phosphorylated protein.


HLH domain binding

Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.


substance K receptor binding

Binding to a substance K receptor.


peroxisome membrane targeting sequence binding

Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane.


fibronectin binding

Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.


RNA polymerase IV core binding

Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production.


complement component C3a binding

Binding to a C3a product of the complement cascade.


protein self-association

Binding to a domain within the same polypeptide.


integrin binding involved in cell-matrix adhesion

Any integrin binding that occurs as part of the process of cell-matrix adhesion.


TFIID-class transcription factor complex binding

Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


TAP binding

Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2.


virus coreceptor activity

Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity.


FHA domain binding

Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich.


P2Y9 nucleotide receptor binding

Binding to a P2Y9 nucleotide receptor.


splicing factor binding

Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.


acetylcholine receptor binding

Binding to an acetylcholine receptor.


somatostatin receptor binding

Binding to a somatostatin receptor.


RNA polymerase I core binding

Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


cell-matrix adhesion mediator activity

The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix.


vasoactive intestinal polypeptide receptor binding

Binding to a vasoactive intestinal polypeptide receptor.


clathrin light chain binding

Binding to a clathrin light chain.


R-SMAD binding

Binding to a receptor-regulated SMAD signaling protein.


histone acetyltransferase binding

Binding to an histone acetyltransferase.


type 1E serotonin receptor binding

Binding to a type 1E serotonin receptor.


netrin receptor binding

Binding to a netrin receptor.


I-SMAD binding

Binding to an inhibitory SMAD signaling protein.


mitochondrion targeting sequence binding

Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.


polo box domain specific binding

Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases.


myosin I light chain binding

Binding to a light chain of a myosin I complex.


type 2 angiotensin receptor binding

Binding to a type 2 angiotensin receptor.


melanocortin receptor binding

Binding to a melanocortin receptor.


gamma-tubulin binding

Binding to the microtubule constituent protein gamma-tubulin.


H1 histamine receptor binding

Binding to a H1 histamine receptor.


alpha-1B adrenergic receptor binding

Binding to an alpha-1B adrenergic receptor.


DEAD/H-box RNA helicase binding

Binding to a DEAD/H-box RNA helicase.


ionotropic glutamate receptor binding

Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.


A2A adenosine receptor binding

Binding to an A2A adenosine receptor.


type II activin receptor binding

Binding to a type II activin receptor.


collagen binding involved in cell-matrix adhesion

Any collagen binding that occurs as part of cell-matrix adhesion.


interleukin-15 binding

Binding to interleukin-15.


neurexin family protein binding

Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.


calcitonin gene-related peptide binding

Binding to calcitonin gene-related peptide (CGRP).


MH1 domain binding

Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.


myosin heavy chain binding

Binding to a heavy chain of a myosin complex.


EH domain binding

Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R.


epidermal growth factor receptor binding

Binding to an epidermal growth factor receptor.


BH2 domain binding

Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.


Toll-like receptor binding

Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.


chemokine (C-C motif) ligand 2 binding

Binding to chemokine (C-C motif) ligand 2.


myosin I head/neck binding

Binding to the head/neck region of a myosin I heavy chain.


type 3 metabotropic glutamate receptor binding

Binding to a type 3 metabotropic glutamate receptor.


ER retention sequence binding

Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.


type II interferon binding

Binding to type II interferon, also known as interferon-gamma.


nuclear androgen receptor binding

Binding to a nuclear androgen receptor.


opsonin binding

Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.


melatonin receptor binding

Binding to a melatonin receptor.


inhibin binding

Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers.


receptor serine/threonine kinase binding

Binding to a receptor that possesses protein serine/threonine kinase activity.


ELYC domain binding

Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC.


amino-terminal vacuolar sorting propeptide binding

Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles.


WW domain binding

Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.


RNA polymerase II general transcription initiation factor binding

Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.


adenosine receptor binding

Binding to an adenosine receptor.


beta-endorphin binding

Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin.


type 2 proteinase activated receptor binding

Binding to a type 2 proteinase activated receptor.


FATZ binding

Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components.


dystroglycan binding

Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).


type 2 cysteinyl leukotriene receptor binding

Binding to a type 2 cysteinyl leukotriene receptor.


alpha-actinin binding

Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.


X11-like protein binding

Binding to X11-like protein, a neuron-specific adaptor protein.


type-I dockerin domain binding

Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain.


ubiquitination-like modification-dependent protein binding

Binding to a protein upon modification by a ubiquitin-like protein of the target protein.


Edg-5 sphingosine 1-phosphate receptor binding

Binding to an Edg-5 sphingosine 1-phosphate receptor.


platelet-derived growth factor binding

Binding to platelet-derived growth factor.


complement component C1q complex binding

Binding to a C1q complex, a component of the classical complement cascade.


corticotropin-releasing hormone receptor 2 binding

Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery.


HMG box domain binding

Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.


G protein-coupled nucleotide receptor binding

Binding to a G protein-coupled (metabotropic) nucleotide receptor.


profilin binding

Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.


mono-ADP-D-ribose modification-dependent protein binding

Binding to a protein upon mono-ADP-ribosylation of the target protein.


chemokine (C-C motif) ligand 5 binding

Binding to chemokine (C-C motif) ligand 5.


POZ domain binding

Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.


G protein-coupled GABA receptor binding

Binding to a G protein-coupled (metabotropic) GABA receptor.


G protein-coupled serotonin receptor binding

Binding to a metabotropic serotonin receptor.


disordered domain specific binding

Binding to a disordered domain of a protein.


benzodiazepine receptor binding

Binding to a peripheral benzodiazepine receptor (PBR).


protein insertion into ER membrane by stop-transfer membrane-anchor sequence

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.


negative regulation of cellular response to amino acid starvation

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation.


social behavior

Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.


positive regulation of superoxide dismutase activity

Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity.


telencephalon astrocyte cell migration

The orderly movement of an astrocyte cell through the telencephalon.


telencephalon glial cell migration

The orderly movement of glial cells through the telencephalon.


pyramidal neuron migration to cerebral cortex

The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex.


oligodendrocyte cell migration from the subpallium to the cortex

The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development.


cerebral cortex radial glia-guided migration

The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.


telencephalon microglial cell migration

The orderly movement of microglial cells through the telencephalon.


telencephalon oligodendrocyte cell migration

The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population.


glossopharyngeal nerve development

Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.


negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


negative regulation of nucleotide-binding oligomerization domain containing signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway.


negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.


MAP kinase serine/threonine phosphatase activity

Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate.


MAP kinase phosphatase activity

Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate.


MAP kinase tyrosine phosphatase activity

Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate.


MAP kinase tyrosine/serine/threonine phosphatase activity

Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.


neuron-neuron synaptic transmission

The process of synaptic transmission from a neuron to another neuron across a synapse.


epidermal-dermal junction

biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction.


biochanin-A reductase activity

Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + H+ + NADPH.


positive regulation of intestinal epithelial cell development

Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development.


cellular response to amitrole

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus.


response to amitrole

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus.


NADPH-adrenodoxin reductase activity

Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.


succinate-semialdehyde dehydrogenase (NAD+) activity

Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.


regulation of macrophage chemotaxis

Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


regulation of leukocyte chemotaxis

Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.


regulation of natural killer cell chemotaxis

Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis.


negative regulation of macrophage chemotaxis

Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


negative regulation of leukocyte chemotaxis

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.


regulation of monocyte chemotaxis

Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.


regulation of eosinophil chemotaxis

Any process that modulates the frequency, rate or extent of eosinophil chemotaxis.


positive regulation of B cell chemotaxis

Any process that activates or increases the frequency, rate or extent of B cell chemotaxis.


negative regulation of lymphocyte chemotaxis

Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.


negative regulation of B cell chemotaxis

Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis.


positive regulation of myeloid dendritic cell chemotaxis

Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis.


negative regulation of myeloid dendritic cell chemotaxis

Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis.


positive regulation of lymphocyte chemotaxis

Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.