intracellular aspartate homeostasis

A homeostatic process involved in the maintenance of a steady state level of aspartate within a cell.


biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).


cellular response to endothelin

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3).


inorganic diphosphate phosphatase activity

Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate.


Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+.


negative regulation of DNA damage response, signal transduction by p53 class mediator

Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.


peptidyl-aspartic acid modification

The modification of peptidyl-aspartic acid.


phagosome maturation involved in apoptotic cell clearance

A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.


isocitrate metabolic process

The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.


regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress.


positive regulation of vascular associated smooth muscle cell dedifferentiation

Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation.


zinc ion transmembrane transporter activity

Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.


Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside.


effector-mediated perturbation of host innate immune response by symbiont

A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


regulation of phospholipid efflux

Any process that modulates the frequency, rate or extent of phospholipid efflux.


protein lipoylation

The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.


somatostatin receptor activity

Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).


Notch signaling pathway involved in heart induction

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The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.


Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H+.


response to dsDNA

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.


S-methylmethionine metabolic process

The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle.


negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator.


forebrain astrocyte differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.


positive regulation of defense response to virus by host

Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.


cytoplasm protein quality control

The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.


hydrogen biosynthetic process

The chemical reactions and pathways resulting in the formation of H2 (dihydrogen).


regulation of microglial cell activation

Any process that modulates the frequency, rate or extent of microglial cell activation.


negative regulation of response to food

Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus.


protein kinase C activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.


female germline ring canal formation, actin assembly

Recruitment and organization of actin filaments in female germline ring canals.


acyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.


Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+.


chorismate metabolic process

The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid.


regulation of peptide antigen transport

Any process that modulates the frequency, rate or extent of peptide antigen transport.


Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2.


O antigen biosynthetic process

The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in).


phosphoglycerate kinase activity

Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+.


cleistothecium development

The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.


UMP kinase activity

Catalysis of the reaction: ATP + UMP = ADP + UDP.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in).


steroid 22-alpha hydroxylase activity

Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O.


T-helper cell differentiation

The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.


de novo centriole assembly

Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects.


positive regulation of lung alveolus development

Any process that activates or increases the frequency, rate or extent of lung alveolus development.


phenol 2-monooxygenase activity

Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O.


mammillotectal axonal tract development

The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus.


Wnt receptor activity

Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.


P-type potassium:proton transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).


benzene catabolic process

The chemical reactions and pathways resulting in the breakdown of benzene.


closure of embryonic heart tube

Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold.


Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline.


vagus nerve morphogenesis

The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.


positive regulation of cell cycle process

Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.


chitin binding

Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.


response to tumor cell

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.


regulation of ecdysone receptor-mediated signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor-mediated signaling pathway.


pons reticulospinal tract morphogenesis

Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord.


response to leptomycin B

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus.


proboscis morphogenesis, eye-antennal disc-derived

The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized.


The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine.


W-molybdopterin cofactor catabolic process

The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.


cellular response to L-glutamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus.


geraniol kinase activity

Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate.


midbrain-hindbrain boundary initiation

The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


Catalysis of the reaction: 3-hydroxybenzoate + H+ + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD+.


ventricular cardiac muscle cell membrane repolarization

The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.


indole 2,3-dioxygenase activity

Catalysis of the reaction: indole + O2 = 2-formamidobenzaldehyde.


purine nucleoside binding

Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.


negative regulation of semaphorin-plexin signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway.


negative regulation of vascular associated smooth muscle cell dedifferentiation

Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation.


polyprenyltransferase activity

Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).


L-arabitol metabolic process

The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group.


negative regulation of L-threonine import across plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of L-threonine import into cell.


voluntary skeletal muscle contraction

A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.


decanoyltransferase activity

Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule.


2-hydroxyglutarate dehydrogenase activity, forward reaction

Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor.


ADP metabolic process

The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate.


negative regulation of high-density lipoprotein particle clearance

Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


cytosine transmembrane transporter activity

Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other.


regulation of tube length, open tracheal system

Ensuring that a tube in an open tracheal system is of the correct length.


postsynaptic neurotransmitter receptor activity

Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission.


determination of dorsal/ventral asymmetry

Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis.


symbiont-mediated activation of host inflammasome-mediated signal transduction

A process in which a symbiont subverts an inflammasome-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.


ocellus photoreceptor cell development

Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus.


neuromast support cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).


dITP diphosphatase activity

Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate.


glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group

Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3.


negative regulation of formation of structure involved in a symbiotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism.


cellular response to jasmonic acid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.


thyroid hormone catabolic process

The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


embryonic dorsal fin morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins.


(13S)-vitexifolin A synthase activity

Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate.


geraniol 10-hydroxylase activity

Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O.


cellular response to camptothecin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.


Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP.


thiol S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether.


NAD-dependent histone H3K14 deacetylase activity

Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.


abscisic acid binding

Binding to abscisic acid, a plant hormone that regulates aspects of plant growth.


cellular response to ergosterol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus.


PEP carboxykinase C4 photosynthesis

The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK).


cellular response to formaldehyde

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus.


glioblast division

The process resulting in the physical partitioning and separation of a glioblast into daughter cells.


alpha-1,4-glucan synthase activity

Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP.


ureter urothelium development

The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter.


sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization

The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization.


negative regulation of determination of dorsal identity

Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity.


positive regulation of angiogenesis

Any process that activates or increases angiogenesis.


platelet-derived growth factor receptor activity

Combining with platelet-derived growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


cellular response to amine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.


Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in).


presynaptic active zone assembly

The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.


iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide

The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide.


positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation.


alkyl hydroperoxide reductase activity

Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.


parasexual reproduction with cellular fusion

A type of reproduction in which new individuals are produced from two individuals, with the fusion of two somatic cells.


organellar voltage-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane.


hydroperoxy icosatetraenoate dehydratase activity

A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H2O.


itaconyl-CoA hydratase activity

Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O.


sperm incapacitation

The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males.


adrenal cortex formation

The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).


regulation of cornification

Any process that modulates the frequency, rate or extent of cornification.


negative regulation of response to cytokine stimulus

Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus.


post-embryonic dorsal fin morphogenesis

The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins.


sulfur amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.


amine dehydrogenase activity

Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+.


stizolobate synthase activity

Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde.


amyloid precursor protein metabolic process

The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.


sexual sporulation resulting in formation of a multicellular or syncytial spore

The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.


traversing start control point of mitotic cell cycle

A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.


O-phosphoserine sulfhydrylase activity

Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate.


anterior lateral line nerve glial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve.


Lugaro cell differentiation

The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


dissimilatory sulfite reductase activity

Catalysis of the reactions: [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H+ + sulfite and [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H+ + sulfite.


growth plate cartilage chondrocyte morphogenesis

The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.


regulation of hepatic stellate cell proliferation

Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation.


quinolinate catabolic process

The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


intracellular mRNA localization involved in anterior/posterior axis specification

Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis.


bioluminescence

The production of light by certain enzyme-catalyzed reactions in cells.


Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H+.


mitochondrion-endoplasmic reticulum membrane tether activity

The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.


'de novo' GDP-L-fucose biosynthetic process

The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271).


positive regulation of hepatocyte growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.


mammary gland formation

The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme.


negative regulation of hematopoietic progenitor cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.


Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH.


epistomal sclerite development

The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure.


oxysterol binding

Binding to oxysterol, an oxidized form of cholesterol.


positive regulation of hepatic stellate cell activation

Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.


regulation of cytolysis

Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm.


cellular response to lipoteichoic acid

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


agglutination involved in conjugation with mutual genetic exchange

The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism.


SREBP-SCAP complex retention in endoplasmic reticulum

Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER.


cardioblast cell fate specification

The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


carbon fixation

A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates).


actin cortical patch assembly

Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.


negative regulation of response to calcium ion

Any process that stops, prevents or reduces the frequency, rate or extent of response to calcium ion.


negative regulation of erythrocyte aggregation

Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation.


positive regulation of the force of heart contraction by epinephrine

The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction.


anterior/posterior pattern specification involved in ureteric bud development

The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate.


response to decalin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decalin stimulus.


cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity

Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P).


positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.


positive regulation of C-C chemokine receptor CCR7 signaling pathway

Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway.


prothoracic disc development

Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle.


FAD metabolic process

The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide.


peptidyl-tyrosine dehydrogenation

The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues.


regulation of dopamine receptor signaling pathway

Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


swim bladder formation

The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ.


psychomotor behavior

The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument.


Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+.


The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


IRES-dependent translational initiation of linear mRNA

The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation.


regulation of branching involved in salivary gland morphogenesis

Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium.


trans-activation response element binding

Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter.


cellulose-polysulfatase activity

Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin.


ultradian rhythm

The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours.


protein-phosphocysteine-glucose phosphotransferase system transporter activity

Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


telomeric loop disassembly

The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.


substantia propria of cornea development

The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure.


snoRNA guided rRNA 2'-O-methylation

The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation.


methylenediurea deaminase activity

Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea.


protein localization to actin filament bundle

A process in which a protein is transported to, or maintained in, the location of an actin filament bundle.


Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate.


voltage-gated calcium channel activity involved SA node cell action potential

Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


positive regulation of spore germination

Any process that activates or increases the frequency, rate or extent of spore germination.


endoribonuclease activity, cleaving miRNA-paired mRNA

Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA.


histone H3K56 acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56).


induction of negative chemotaxis

Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical.


cerebral cortex radially oriented cell migration

The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.


Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H+ + NADH.


response to neutral pH

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP.


positive gravitropism

The orientation of plant parts towards gravity.


(+)-pulegone reductase, (+)-isomenthone as substrate, activity

Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+.


chlorophyll binding

Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment.


alpha-beta T cell lineage commitment

The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.


high-density lipoprotein particle binding

Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.


rRNA primary transcript binding

Binding to an unprocessed ribosomal RNA transcript.


ferrichrome biosynthetic process

The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.


response to ethylene

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus.


regulation of spore-bearing organ development

Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores.


N-formylglutamate deformylase activity

Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate.


negative regulation of mononuclear cell migration

Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.


menstruation

The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.


regulatory T cell apoptotic process

Any apoptotic process in a regulatory T cell.


phospholipid-hydroperoxide glutathione peroxidase activity

Catalysis of the reaction: a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.


Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+.


posterior commissure morphogenesis

Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon.


spermidine dehydrogenase activity

Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor.


regulation of late endosome to lysosome transport

Any process that modulates the frequency, rate or extent of late endosome to lysosome transport.


aspartate transamidation

The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group.


cellular detoxification of metal ion

Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion.


cell adhesion involved in multi-species biofilm formation

The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species.


sinoatrial valve formation

The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


multi-multicellular organism process

A multicellular organism process which involves another multicellular organism of the same or different species.


glucose oxidase activity

Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2.


positive regulation of gonad development

Any process that activates or increases the frequency, rate or extent of gonad development.


Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine.


flower phyllotactic patterning

The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium.


selenium-containing prosthetic group metabolic process

The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments.


cyanogenic glycoside metabolic process

The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits.


ectodermal cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.


flavonoid catabolic process

The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton.


lutein biosynthetic process

The chemical reactions and pathways resulting in the formation of lutein.


right lung morphogenesis

The process in which anatomical structures of the right lung are generated and organized.


positive regulation of cardioblast proliferation

Any process that activates or increases the frequency, rate or extent of cardioblast proliferation.


epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.


ethanol-acetate fermentation to butyrate and caproate

The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP.


lysine biosynthetic process via alpha-aminoadipate and saccharopine

The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine.


protein propionyltransferase activity

Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide.


sterol catabolic process

The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


internal mammary gland bud epithelial cell differentiation

The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape.


vitamin catabolic process

The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


3-ethylmalate synthase activity

Catalysis of the reaction: butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H+.


corticospinal neuron axon decussation

The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side.


thyroxine 5-deiodinase activity

Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.


maintenance of protein localization to heterochromatin

A process in which a protein is maintained in a location in telomeric heterochromatin.


development of secondary male sexual characteristics

The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.


dichloromethane dehalogenase activity

Catalysis of the reaction: dichloromethane + H2O = 2 chloride + formaldehyde + 2 H+.


SAGA complex localization to transcription regulatory region

Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene.


negative regulation of natural killer cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation.


photosynthetic acclimation

A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light.


asparagine catabolic process via L-aspartate

The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate.


N-terminal protein amino acid glucuronylation

The glucuronylation of the N-terminal amino acid of proteins.


embryonic process involved in female pregnancy

A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.


Spemann organizer formation at the dorsal lip of the blastopore

Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan.


taste bud development

The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors.


response to dinitrophenol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus.


caffeoyl-CoA: alcohol caffeoyl transferase activity

Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA.


regulation of skeletal muscle tissue development

Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.


intracellular chloride ion homeostasis

A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell.


negative regulation of cell proliferation involved in compound eye morphogenesis

Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.


regulation of olefin biosynthetic process

Any process that modulates the frequency, rate or extent of olefin biosynthetic process.


chitin-based cuticle development

Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.


compound leaf morphogenesis

The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development.


histone H3K37 methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group to the lysine residue at position 37 of the histone H3 protein.


2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity

Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide.


levan fructotransferase (DFA-IV-forming) activity

Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide.


vitelline membrane formation

Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg.


negative regulation of oospore formation

Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes.


Atg8-family conjugating enzyme activity

Isoenergetic transfer of an Atg8 family modifer from one protein to a phosphatidylethanolamine or  phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X.


lipoprotein amino acid oxidation

The modification of a lipoprotein by oxidation of one or more amino acids in the protein.


9-cis-beta-carotene 9',10'-cleavage oxygenase activity

Catalysis of the reaction: 9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone.


multivesicular body fusion to apical plasma membrane

The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell.


response to UV-B

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.


response to forskolin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.


ABC-type peptide antigen transporter activity

Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate.


tabersonine 16-hydroxylase activity

Catalysis of the reaction: H+ + NADPH + O2 + tabersonine = 16-hydroxytabersonine + H2O + NADP+.


regulation of cellular extravasation

Any process that modulates the frequency, rate, or extent of cellular extravasation.


cellular response to methylglyoxal

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.


branching involved in blood vessel morphogenesis

The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.


negative regulation of hair follicle cell proliferation

Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation.


negative regulation of G protein-coupled receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.


diphenyl ether 1,2-dioxygenase activity

Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+.


serotonin binding

Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


positive regulation of neural retina development

Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol).


establishment of protein localization to spindle pole body

The directed movement of a protein to a specific location at the spindle pole body.


L-glutamine biosynthetic process

The chemical reactions and pathways resulting in the formation of L-glutamine.


formin-nucleated actin cable assembly

The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


ADP-D-ribose binding

Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment.


negative regulation of adipose tissue development

Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.


benzoyl acetate-CoA ligase activity

Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA.


transcription elongation factor activity

A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.


negative regulation of cellodextrin catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin catabolic process.


positive regulation of sporangium development

Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms.


epithelial cell morphogenesis involved in gastrulation

The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.


Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.


response to vitamin B1

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus.


basidium development

The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi.


establishment of planar polarity of larval imaginal disc epithelium

Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates.


positive regulation of long-day photoperiodism, flowering

Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase.


circadian temperature homeostasis

Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.


establishment or maintenance of microtubule cytoskeleton polarity

Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.


class II DNA-(apurinic or apyrimidinic site) endonuclease activity

Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.


microsporocyte differentiation

The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell.


NLRP3 inflammasome complex assembly

The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell.


cellular response to oxidopamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus.


regulation of cumulus cell differentiation

Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation.


diestrus

The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum.


acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.


pyruvate metabolic process

The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.


compound eye photoreceptor development

The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.


Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside.


mRNA dihydrouridine synthase activity

Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+.


pollen development

The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.


ganglion structural organization

The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure.


taurine dioxygenase activity

Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite.


skeletal muscle satellite cell activation

The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.


plant-type cell wall organization

A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana.


negative regulation of myotube differentiation

Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


karyogamy

The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.


amine biosynthetic process

The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.


regulation of gluconate transmembrane transport

Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore.


plasmacytoid dendritic cell cytokine production

Any process that contributes to cytokine production by a plasmacytoid dendritic cell.


protein N-linked glucosylation via asparagine

A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue.


box C/D RNA metabolic process

The chemical reactions and pathways involving box C/D type small nucleolar RNA.


bile acid receptor activity

Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile.


4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity

Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA <=> 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A.


D-alanine [D-alanyl carrier protein] ligase activity

Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate.


maintenance of vesicle location

Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere.


Ran protein signal transduction

The series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state.


membrane depolarization during action potential

The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


regulation of cilium movement involved in cell motility

Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility.


peptidyl-allysine oxidation to 2-aminoadipic acid

The oxidation of allysine to 2-aminoadipic acid.


Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD+ = H+ + NADH + phenanthrene-3,4-diol.


regulation of MyD88-dependent toll-like receptor signaling pathway

Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.


auditory receptor cell fate commitment

The process in which the cellular identity of auditory hair cells is acquired and determined.


holo-citrate lyase synthase activity

Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase.


response to parasitic plant

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant.


vagina development

The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.


sulfolipid metabolic process

The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid.


lovastatin nonaketide synthase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+.


negative regulation of choline O-acetyltransferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of choline O-acetyltransferase activity.


linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity

Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O <=> vicianose + linalool.


negative regulation of emodin biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of emodin biosynthetic process.


fosmidomycin transmembrane transporter activity

Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other.


Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate.


positive regulation of humoral immune response

Any process that activates or increases the frequency, rate, or extent of a humoral immune response.


Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione.


deoxyribose-phosphate aldolase activity

Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.


regulation of embryonic skeletal joint development

Any process that modulates the frequency, rate or extent of embryonic skeletal joint development.


positive regulation of urine volume by pressure natriuresis

An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis.


regulation of lung alveolus development

Any process that modulates the frequency, rate or extent of lung alveolus development.


response to pheromone regulating conjugation with mutual genetic exchange

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion.


sexual sporulation resulting in formation of a cellular spore

The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.


regulation of growth of unicellular organism as a thread of attached cells

Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.


L-phenylalanine biosynthetic process from chorismate via phenylpyruvate

The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate.


regulation of dopamine uptake involved in synaptic transmission

Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell.


protein localization to T-tubule

A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


UDP-galactose biosynthetic process

The chemical reactions and pathways resulting in the formation of UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate.


isoquinoline alkaloid metabolic process

The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.


positive regulation of hormone metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone.


tropism

The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it.


single subunit type RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


positive regulation of cerebellar granule cell migration by calcium

The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration.


opsonization

The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.


Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside <=> quercetin 3-O-rhamnoside-7-O-glucoside + UDP.


monomethyl-sulfatase activity

Catalysis of the reaction: H2O + monomethyl sulfate = H+ + methanol + sulfate.


regulation of stress response to copper ion

Any process that modulates the frequency, rate or extent of stress response to copper ion.


extraction of mislocalized protein from membrane

The removal of a mislocalized protein from a cellular membrane.


negative regulation of maltoheptaose metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose metabolic process.


Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid.


regulation of adipose tissue development

Any process that modulates the frequency, rate or extent of adipose tissue development.


glutaryl-CoA dehydrogenase activity

3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].


o-aminophenol oxidase activity

Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O.


kojibiose phosphorylase activity

Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose.


intermediate mesoderm morphogenesis

The process in which the anatomical structures of the intermediate mesoderm are generated and organized.


terrequinone A biosynthetic process

The chemical reactions and pathways resulting in the formation of terrequinone A.


Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP.


membrane repolarization

The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.


negative regulation of cellular response to macrophage colony-stimulating factor stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus.


histone H3T11 kinase activity

Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3.


G protein-coupled receptor signaling pathway involved in social behavior

Any G protein-coupled receptor signaling pathway that is involved in social behavior.


cellular response to folic acid

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.


response to thiabendazole

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus.


3-oxo-palmitate decarboxylase activity

Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide.


fumagillin catabolic process

The chemical reactions and pathways resulting in the breakdown of fumagillin.


His-Purkinje system cell development

The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles.


GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine

The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.


induction of programmed cell death by hormones

Any process induced by hormones that directly activates any of the steps required for programmed cell death.


Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + kinetin-7-N-glucoside + UDP.


histone H3K36me2/H3K36me3 demethylase activity

Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


sulfoacetaldehyde lyase activity

Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite.


regulation of glucosylceramidase activity

Any process that modulates the frequency, rate or extent of glucosylceramidase activity.


Notch signaling involved in heart development

The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.


glutathione oxidase activity

Catalysis of the reaction: 2 glutathione + O2 = glutathione disulfide + H2O2.


sulfur oxygenase/reductase activity

Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+.


regulation of beta-lactamase activity

Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid.


cellular response to nitric oxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.


prostacyclin receptor activity

Combining with prostacyclin (PGI(2)) to initiate a change in cell activity.


protein insertion into plasma membrane raft

The process in which a protein is incorporated into a plasma membrane raft.


mRNA CDS binding

Binding to an mRNA molecule coding sequence (CDS).


short-chain fatty acid metabolic process

The chemical reactions and pathways involving a fatty acid with an aliphatic tail of less than 6 carbons.


auditory behavior

The behavior of an organism in response to a sound.


Malpighian tubule development

The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.


FMN reductase (NADPH) activity

Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+.


negative regulation of response to oxidative stress

Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress.


Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine.


2-hydroxyacyl-CoA lyase activity

Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA.


Notch receptor processing, ligand-independent

The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.


Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate.


positive regulation of lipid localization

Any process that activates or increases the frequency, rate or extent of lipid localization.


atrioventricular node cell fate commitment

The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells.


arabinoxylan binding

Binding to arabinoxylan.


cytoplasmic translational elongation

The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.


regulation of vesicle targeting, to, from or within Golgi

Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.


fermentative hydrogen production

The fermentation of organic substances with a net release of hydrogen.


oocyte microtubule cytoskeleton organization

Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.


Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose.


salicylate 1-monooxygenase activity

Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2.


phthalate 4,5-cis-dihydrodiol dehydrogenase activity

Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + H+ + NADH.


Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+.


positive regulation of mannotriose transport

Any process that activates or increases the frequency, rate or extent of mannotriose transport.


homogentisate catabolic process

The chemical reactions and pathways resulting in the breakdown of homogentisate.


Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site.


Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP.


regulation of hindgut contraction

Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.


lymphoid lineage cell migration

The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.


fused antrum stage

The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space.


ferric-chelate reductase (NADPH) activity

Catalysis of the reaction: 2 Fe3+-siderophore + NADP+ + H+ -> 2 Fe2+-siderophore + NADPH.


enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity

Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+.


glycerol to glycerone phosphate metabolic process

The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate.


negative regulation of opioid receptor signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway.


ammonia-lyase activity

Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.


quinaldate 4-oxidoreductase activity

Catalysis of the reaction: A + H2O + quinaldate = AH(2) + kynurenate.


ajugose synthase activity

Catalysis of the reaction: 2 verbascose <=> ajugose + stachyose.


phosphogluco-amylopectin water dikinase activity

Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin.


p-coumarate 3-hydroxylase activity

Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+.


neuron remodeling

The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.


anaerobic 2,4,6-trinitrotoluene metabolic process

The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen.


G protein-coupled pyrimidinergic nucleotide receptor activity

Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


endothelial tube morphogenesis

The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.


C-5 sterol desaturase activity

Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.


dATP binding

Binding to dATP, deoxyadenosine triphosphate.


negative regulation of natural killer cell mediated immunity

Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.


naringenin 2-hydroxylase activity

Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O.


typhasterol C-23 hydroxylase activity

Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor.


3-ketopimelyl-CoA thiolase activity

Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA.


flavonoid 3',5'-hydroxylase activity

Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O.


regulation of cellular response to manganese ion

Any process that modulates the frequency, rate or extent of cellular response to manganese ion.


ERBB2-EGFR signaling pathway

The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.


semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis

Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis.


Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17.


terpentetriene synthase activity

Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene.


funalenone catabolic process

The chemical reactions and pathways resulting in the breakdown of funalenone.


transition metal ion transmembrane transporter activity

Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


branching involved in labyrinthine layer morphogenesis

The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.


regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis.


regulation of systemic arterial blood pressure by norepinephrine

The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine.


uronic acid transmembrane transporter activity

Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose.


relaxation of skeletal muscle

A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases.


regulation of motor neuron apoptotic process

Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.


oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor.


negative regulation of toll-like receptor 6 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway.


negative regulation of smooth muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.


alpha-ketoglutarate-dependent xanthine dioxygenase activity

Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate.


catechol O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.


mannan binding

Binding to mannan.


vitamin D 23-hydroxylase activity

Catalysis of the hydroxylation of C-23 of any form of vitamin D.


Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.


homoserine catabolic process

The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid.


alpha-L-arabinofuranosidase activity

Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.


negative regulation of R7 cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation.


dATP biosynthetic process

The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).


(S)-2-hydroxy-acid oxidase activity

Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.


cone photoresponse recovery

The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.


tryparedoxin peroxidase activity

Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O.


regulation of regulatory T cell differentiation

Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.


response to azide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus.


fatty acid derivative binding

Binding to fatty acid derivative.


thioether S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.


fatty acid primary amide metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform primary fatty amides.


superior salivary nucleus development

The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.


germ-line cyst formation

Formation of a group of interconnected cells derived from a single gonial founder cell.


Delta8-sphingolipid desaturase activity

Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor.


renal outer medulla development

The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla.


establishment of competence for transformation

The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.


negative phototaxis

The directed movement of a cell or organism away from a source of light.


Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H+ + staurosporine.


positive regulation of SREBP signaling pathway

Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway.


dorsal motor nucleus of vagus nerve structural organization

The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure.


emodin biosynthetic process

The chemical reactions and pathways resulting in the formation of emodin.


biogenic amine biosynthetic process

The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.


sphingomyelin catabolic process

The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.


positive regulation of flagellated sperm motility

Any process that activates or increases the frequency, rate or extent of flagellated sperm motility.


Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP.


positive regulation of cell-cell adhesion mediated by integrin

Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin.


negative regulation of sequestering of triglyceride

Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.


negative regulation of mating type switching

Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching.


bacitracin A metabolic process

The chemical reactions and pathways involving bacitracin A.


annealing activity

An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule.


regulation of glutamate receptor signaling pathway

Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway.


allose kinase activity

Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate.