A7KAA9_9PHYC Uncharacterized protein Z849R (trembl)


A7KAB0_9PHYC Uncharacterized protein z850L (trembl)


L7P648_9CIRC Replication-associated protein (trembl)


M1JD72_9VIRU Nonstructural replication protein-like protein (trembl)


K7X4M8_9MONO Non-structural protein V (trembl)


suppression by virus of host type I interferon-mediated signaling pathway

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity

Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


modulation by symbiont of host cellular process

Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism.


K7X4N2_9MONO RNA-directed RNA polymerase L (trembl)


structural constituent of virion

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The action of a molecule that contributes to the structural integrity of a virion.


virion assembly

A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed.


K7XBE1_9MONO Attachment protein (trembl)


exo-alpha-sialidase activity

Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.


host cell surface receptor binding

Binding to a receptor on the host cell surface.


viral life cycle

A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.


virion attachment to host cell

The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.


virion membrane

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The lipid bilayer surrounding a virion.


viral nucleocapsid

The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.


helical viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure.


ribonucleoprotein complex

A macromolecular complex that contains both RNA and protein molecules.


K7XN73_9MONO Fusion glycoprotein F0 (trembl)


fusion of virus membrane with host plasma membrane

Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm.


A0A8K0YXK4_9VIRU Movement protein TGB2 (trembl)


A0A8K0YXL0_9VIRU Movement protein TGBp3 (trembl)


A0A8K0YXN3_9VIRU Triple gene block protein 1 (trembl)


A0A8K1DQQ3_9VIRU Capsid protein (trembl)


A0A8K1DQT3_9VIRU Viral replicase (trembl)


A0A8K1DR73_9VIRU RNA silencing suppressor (trembl)


Q91UI8_9VIRU RNA silencing suppressor (trembl)


Q91UJ0_9VIRU Movement protein TGBp3 (trembl)


Q91UJ1_9VIRU Movement protein TGB2 (trembl)


A0A0U3TCD6_9VIRU Nucleocapsid protein (trembl)


A0A0U4CCN7_9VIRU RNA-directed RNA polymerase L (trembl)


viral genome replication

Any process involved directly in viral genome replication, including viral nucleotide metabolism.


A0A223A3I0_9CLOS Putative coat protein (trembl)


A0A223A3Q7_9CLOS Putative 58 kDa protein (Fragment) (trembl)


A0A223A460_9CLOS Putative transmembrane protein (trembl)


A0A223A4D7_9CLOS Putative thaumatin-like protein (trembl)


A0A223A549_9CLOS Heat shock protein 70-like protein (trembl)


G8H9D4_9VIRU Putative replicase (trembl)


host cell Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.


A0A6G5X254_9VIRU RNA-directed RNA polymerase L (trembl)


A0A6G5X2C3_9VIRU Uncharacterized protein (trembl)


POLS_ABPVR Structural polyprotein (sprot)


POLN_ABPVR Replicase polyprotein (sprot)


A0A0C5ARY4_9VIRU Envelopment polyprotein (trembl)


fusion of virus membrane with host endosome membrane

Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell.


membrane fusion involved in viral entry into host cell

Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell.


host cell Golgi membrane

The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus.


A0A0C5AUQ0_9VIRU RNA-directed RNA polymerase L (trembl)


host cell endoplasmic reticulum-Golgi intermediate compartment

A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport.


K4HHN2_ARV Non-structural transmembrane glycoprotein (trembl)


endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.


host cell endomembrane system

A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction.


K4HIF6_ARV Virion transmembrane glycoprotein (trembl)


A0A0A7W5B8_9POLY Large T antigen (trembl)


disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity

Any process in which interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1).


perturbation by virus of host G1/S transition checkpoint

A process in which a virus interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction.


A0A0A7W5I1_9POLY Minor capsid protein (trembl)


A0A0A7W722_9POLY Minor capsid protein VP2 (trembl)


Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.


rRNA (guanine) methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine.


ribonucleoside triphosphate phosphatase activity

Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.


maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


preribosome, large subunit precursor

A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.


AAP_AAV2S Assembly activating protein AAP (sprot)


host cell nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic host cells.


protein binding

Binding to a protein.


perturbation by virus of G2/M transition of host mitotic cell cycle

A process in which a virus interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase.


permeabilization of host organelle membrane involved in viral entry into host cell

Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm.


viral entry via permeabilization of inner membrane

The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane.


endocytosis involved in viral entry into host cell

Any endocytosis that is involved in the uptake of a virus into a host cell.


clathrin-dependent endocytosis of virus by host cell

Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus.


A0A1J1DNU3_9TOMB Capsid protein (trembl)


T=3 icosahedral viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.


A0A1J1DWM6_9TOMB RNA-directed RNA polymerase (trembl)


A0A916KNR7_9POXV Uncharacterized protein (trembl)


A0A916KNR8_9POXV Uncharacterized protein (trembl)


A0A916KNT8_9POXV RING-type domain-containing protein (trembl)


A0A916KNU6_9POXV Thymidine kinase (trembl)


A0A916KNV3_9POXV VLTF-2 late transcription factor 2 (trembl)


A0A916KNV7_9POXV Ribonucleoside-diphosphate reductase small chain (trembl)


A0A916KNV8_9POXV Uncharacterized protein (trembl)


A0A916KNW2_9POXV DNA polymerase (trembl)


A0A916KNW7_9POXV Poly(A) polymerase catalytic subunit (trembl)


A0A916KNX1_9POXV Inhibitor of apoptosis 3 (trembl)


A0A916KNX6_9POXV mRNA decapping enzyme (Cop-D9R) (trembl)


A0A916KNY5_9POXV Uncharacterized protein (trembl)


A0A916KNY7_9POXV DNA topoisomerase (trembl)


A0A916KNY8_9POXV Entry-fusion complex protein OPG086 (trembl)


A0A916KNZ0_9POXV Protein tyrosine phosphatase 2 (trembl)


A0A916KNZ1_9POXV Early transcription factor 82 kDa subunit (trembl)


positive regulation of DNA-templated transcription

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.


A0A916KNZ4_9POXV Uncharacterized protein (trembl)


A0A916KNZ5_9POXV DNA-directed RNA polymerase (trembl)


A0A916KP00_9POXV Uncharacterized protein (trembl)


A0A916KP01_9POXV RNA helicase NPH-II (trembl)


A0A916KP05_9POXV Ser/thr kinase (Cop-B1R) (trembl)


A0A916KP12_9POXV Protein phosphatase 1B (trembl)


cation binding

Binding to a cation, a charged atom or group of atoms with a net positive charge.


A0A916KP14_9POXV Entry-fusion complex component, myristylprotein (trembl)


A0A916KP16_9POXV Uncharacterized protein (trembl)


A0A916KP27_9POXV Phospholipase A2-like domain-containing protein (trembl)


phospholipase A2 activity

Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.


phospholipid metabolic process

The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.


arachidonic acid secretion

The controlled release of arachidonic acid from a cell or a tissue.


A0A916KP28_9POXV Sensor histidine kinase (trembl)


A0A916KP29_9POXV 62 kDa protein (trembl)


response to antibiotic

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.


A0A916KP31_9POXV Inhibitor of apoptosis 4 (trembl)


A0A916KP38_9POXV IMV MP/virus entry (Cop-A28L) (trembl)


A0A916KP40_9POXV Uncharacterized protein (trembl)


A0A916KP42_9POXV Entry and fusion IMV protein (Cop-L5R) (trembl)


A0A916KP45_9POXV Probable AP endonuclease (trembl)


A0A916KP48_9POXV Uncharacterized protein (trembl)


A0A916KP54_9POXV Leucine rich repeat gene family (trembl)


A0A916KP56_9POXV mRNA-capping enzyme catalytic subunit (trembl)


A0A916KP57_9POXV Viral late gene transcription factor 3 (trembl)


A0A916KP58_9POXV Uncharacterized protein (trembl)


A0A916KP59_9POXV Virion core protein 4b (trembl)


A0A916KP60_9POXV Late 16kDa membrane protein (Cop-J5L) (trembl)


A0A916KP61_9POXV glycylpeptide N-tetradecanoyltransferase (trembl)


A0A916KP62_9POXV RING-type domain-containing protein (trembl)


A0A916KP65_9POXV Uncharacterized protein (trembl)


A0A916KP66_9POXV Uncharacterized protein (trembl)


A0A916KP69_9POXV IMV membrane protein entry/fusion complex component (Cop-A21L) (trembl)


calcium ion binding

Binding to a calcium ion (Ca2+).


A0A916KP74_9POXV Viral membrane associated, early morphogenesis protein (Cop-A9L) (trembl)


A0A916KP75_9POXV P35 apoptosis inhibitor (trembl)


A0A916KP77_9POXV Uncharacterized protein (trembl)


A0A916KP78_9POXV Holliday junction resolvase (trembl)


A0A916KP80_9POXV DNA-directed RNA polymerase 147 kDa polypeptide (trembl)


A0A916KP88_9POXV Uncharacterized protein (trembl)


A0A916KP91_9POXV Virion core cysteine protease (trembl)


A0A916KP92_9POXV Uncharacterized protein (trembl)


A0A916KP98_9POXV Methyltransferase domain-containing protein (trembl)


A0A916KPA4_9POXV N1R/p28-like protein (trembl)


A0A916KPA7_9POXV Cu/Zn superoxide dismutase (trembl)


A0A916KPB0_9POXV Leucine rich repeat gene family (trembl)


A0A916KPB2_9POXV Protein phosphatase 2C (trembl)


A0A916KPB5_9POXV Uncharacterized protein (trembl)


A0A916KPB7_9POXV Uncharacterized protein (trembl)


A0A916KPC0_9POXV Uncharacterized protein (trembl)


A0A916KPC5_9POXV Uncharacterized protein (trembl)


A0A916KPD1_9POXV RNA polymerase-associated transcription-specificity factor RAP94 (trembl)


A0A916KPE1_9POXV Metalloprotease (Cop-G1L) (trembl)


ubiquitin conjugating enzyme binding

Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.


protein polyubiquitination

Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.


positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


ubiquitin ligase complex

A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.


A0A916KPG9_9POXV Myristylated protein, essential for entry/fusion (Cop-A16L) (trembl)


A0A916KPI1_9POXV Uncharacterized protein (trembl)


A0A916KPK6_9POXV Uncharacterized protein (trembl)


A0A916KPL3_9POXV Morph, VETF-s early transcription factor small (trembl)


A0A916KPM7_9POXV Uncharacterized protein (trembl)


A0A916KPN5_9POXV Uncharacterized protein (trembl)


A0A916NWN9_9POXV Early transcription factor 70 kDa subunit (trembl)


A0A916NWQ0_9POXV Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (trembl)


regulation of mRNA 3'-end processing

Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.


A0A916NWS5_9POXV Cell division protein FtsL (trembl)


A0A916NWU2_9POXV Uncharacterized protein (trembl)


A0A916NWV6_9POXV Poly(A) polymerase small subunit VP39 (trembl)


A0A916NWW2_9POXV Uncharacterized protein (trembl)


A0A916NWY4_9POXV Uncharacterized protein (trembl)


A0A916NX03_9POXV Uncharacterized protein (trembl)


A0A916NX23_9POXV S-S bond formation pathway protein substrate (Cop-F9L) (trembl)


A0A916NX88_9POXV N1R/p28-like protein (trembl)


A0A916NXD0_9POXV P35 apoptosis inhibitor (trembl)


A0A916P041_9POXV G-protein coupled receptors family 2 profile 2 domain-containing protein (trembl)


transmembrane signaling receptor activity

Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.


cell surface receptor signaling pathway

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.


A0A916P060_9POXV Uncharacterized protein (trembl)


A0A916P069_9POXV Uncharacterized protein (trembl)


A0A916P091_9POXV dUTPase-like domain-containing protein (trembl)


A0A916P0A8_9POXV IMV membrane protein (Cop-L1R) (trembl)


A0A916P0B4_9POXV Nucleoside triphosphatase I (trembl)


A0A916P0M3_9POXV Uncharacterized protein (trembl)


A0A916P0P8_9POXV Uracil-DNA glycosylase, DNA polymerase processivity factor (trembl)


A0A916P0Q7_9POXV IMV heparin binding surface protein (trembl)


A0A916P0R1_9POXV DNA photolyase (trembl)


Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.


photoreactive repair

The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.


A0A916P0R3_9POXV Uncharacterized protein (trembl)


A0A916P0U8_9POXV Sulfhydryl oxidase FAD-linked (Cop-E10R) (trembl)


A0A916P0V5_9POXV Uncharacterized protein (trembl)


A0A916P0Y0_9POXV NAD-dependent DNA ligase (trembl)


A0A916P100_9POXV Serine/threonine-protein kinase 2 (trembl)


A0A916P625_9POXV Peptidase M10 metallopeptidase domain-containing protein (trembl)


A0A916P648_9POXV Uncharacterized protein (trembl)


A0A916P676_9POXV Uncharacterized protein (trembl)


A0A916P683_9POXV Uncharacterized protein (trembl)


A0A916P690_9POXV Uncharacterized protein (trembl)


A0A916P6A5_9POXV Entry-fusion complex essential component (Cop-H2R) (trembl)


CAPSD_AADNV Capsid protein VP1/VP2 (sprot)


A0A2Z4GIN2_9MONO RNA-directed RNA polymerase (trembl)


A0A1Z2RT16_9VIRU Uncharacterized protein (trembl)


A0A1Z2RT28_9VIRU Virion glycoprotein N-terminal domain-containing protein (trembl)


A0A1Z2RT29_9VIRU Uncharacterized protein (trembl)


A0A1Z2RT07_9VIRU Putative major core protein (trembl)


VP6_APRVF Microtubule-associated protein VP6 (sprot)


viral inner capsid

The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions.


host cytoskeleton

A cellular structure that forms the internal framework of eukaryotic and prokaryotic host cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.


VP5_APRVF Outer capsid protein VP5 (sprot)


viral outer capsid

The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions.


CAPSD_APRVF Putative major capsid protein VP3 (sprot)


T=2 icosahedral viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers.


RDRP_APRVF RNA-directed RNA polymerase VP2 (sprot)


VP1_APRVF Putative structural protein VP1 (sprot)


D4QF72_APBV1 Major virion protein (trembl)


D4QF73_APBV1 Minor virion protein (trembl)


D4QF74_APBV1 Minor virion protein (trembl)


D4QF75_APBV1 Minor virion protein (trembl)


D4QF78_APBV1 Uncharacterized protein (trembl)


AV2_CLVN Uncharacterized 13.1 kDa protein (sprot)


modulation by virus of host process

The process in which a virus effects a change in the structure or processes of its host organism.


negative regulation of gene silencing by regulatory ncRNA

Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.


host cell perinuclear region of cytoplasm

The host cell cytoplasm situated near, or occurring around, the host nucleus.


TRAP_CLVN Transcriptional activator protein (sprot)


REN_CLVN Replication enhancer protein (sprot)


NSP_CLVN Nuclear shuttle protein (sprot)


REP_CLVN Replication-associated protein (sprot)


host cell junction

A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.


host cell plasmodesma

A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell.


A0A1S6PCS2_9VIRU Readthrough protein (trembl)


serine-type exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


T2FEJ9_9POLY Minor capsid protein VP2 (trembl)


T2FFC5_9POLY Major capsid protein VP1 (trembl)


T2FFJ0_9POLY Minor capsid protein (trembl)


A0A0B5GDD0_9REOV Non-structural protein NS2 (trembl)


A0A0B5GGK4_9REOV Core protein VP4 (trembl)


A0A0B5GPD2_9REOV RNA-directed RNA polymerase (trembl)


A0A0B5GT51_9REOV Outer capsid protein VP2 (trembl)


B1PJ62_9REOV Membrane bound protein (trembl)


B4UUP0_9REOV Outer capsid protein VP5 (trembl)


adhesion of symbiont to host cell

The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly.


W5ZZ53_9REOV Inner capsid protein (trembl)


C1BEG0_9VIRU Movement protein TGB2 (trembl)


C1BEG1_9VIRU Movement protein TGBp3 (trembl)


Q8UZK2_9VIRU RNA-dependent RNA polymerase (trembl)


A0A0B5JFR5_9NIDO GP3 envelope protein (trembl)


A0A0B5JKI0_9NIDO GP4 glycoprotein (trembl)


A0A0B5JQL0_9NIDO GP5 glycosylated envelope protein (trembl)


A0A0B5JQL5_9NIDO Replicase polyprotein 1ab (trembl)


A0A0B5JWP0_9NIDO GP2 glycosylated envelope protein (trembl)


A0A0B5JWP6_9NIDO Envelope protein M (trembl)


148R_ASFB7 Uncharacterized membrane protein EP148R (sprot)


PNG3_ASFB7 Uncharacterized membrane protein pNG3 (sprot)


PNG4_ASFB7 Uncharacterized membrane protein pNG4 (sprot)


PNG6_ASFB7 Uncharacterized membrane protein pNG6 (sprot)


host cell cytosol

The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.


taxis

The directed movement of a motile cell or organism in response to an external stimulus.


P22_ASFB7 Inner membrane protein p22 (sprot)


I329L_ASFB7 Transmembrane protein I329L (sprot)


suppression by virus of host toll-like receptor signaling pathway

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism.


VF73R_ASFB7 Uncharacterized protein I73R (sprot)


TFIIS_ASFB7 Transcription factor TFIIS homolog (sprot)


UBC_ASFB7 Ubiquitin-conjugating enzyme E2 (sprot)


DIPP_ASFB7 mRNA-decapping protein g5R (sprot)


suppression by virus of host gene expression

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.


host cell rough endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface.


P12_ASFB7 Inner membrane protein p12 (sprot)


cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.


RPB6_ASFB7 DNA-directed RNA polymerase RPB6 homolog (sprot)


viral transcription

The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.


ARBH_ASFB7 Apoptosis regulator Bcl-2 homolog (sprot)


suppression by virus of host autophagy

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host.


regulation of apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process.


RPB1_ASFB7 DNA-directed RNA polymerase RPB1 homolog (sprot)


DNA-templated viral transcription

A transcription process that uses a viral DNA as a template.


RPB2_ASFB7 DNA-directed RNA polymerase RPB2 homolog (sprot)


RPB10_ASFB7 DNA-directed RNA polymerase RPB10 homolog (sprot)


RIR1_ASFB7 Ribonucleoside-diphosphate reductase large subunit (sprot)


RIR2_ASFB7 Ribonucleoside-diphosphate reductase small chain (sprot)


PK1_ASFB7 Serine/threonine-protein kinase 1 (sprot)


regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.


DPOLX_ASFB7 Repair DNA polymerase X (sprot)


VHLP_ASFB7 Viral histone-like protein (sprot)


host cell endoplasmic reticulum lumen

The volume enclosed by the membranes of the host cell endoplasmic reticulum.


IAP_ASFB7 Inhibitor of apoptosis protein (sprot)


suppression by symbiont of host apoptotic process

Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction.


VPRT_ASFB7 Cysteine protease S273R (sprot)


VF137_ASFB7 Structural protein A137R (sprot)


suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity

Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1.


VF84_ASFB7 Transmembrane protein EP84R (sprot)


VF421_ASFB7 Uncharacterized protein K421R (sprot)


VF145_ASFB7 Uncharacterized protein K145R (sprot)


viral capsid assembly

The assembly of a virus capsid from its protein subunits.


VF69R_ASFB7 Uncharacterized membrane protein X69R (sprot)


disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1).


disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).


VF118_ASFB7 Uncharacterized protein A118R (sprot)


VF859_ASFB7 Probable helicase A859L (sprot)


VF317_ASFB7 Uncharacterized protein F317L (sprot)


VF165_ASFB7 Uncharacterized protein F165R (sprot)


PRIM_ASFB7 Putative helicase/primase complex protein (sprot)


VF205_ASFB7 Uncharacterized protein K205R (sprot)


induction by virus of host autophagy

Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.


VF424_ASFB7 Probable methyltransferase EP424R (sprot)


VF152_ASFB7 Uncharacterized protein EP152R (sprot)


EP153_ASFB7 Lectin-like protein EP153R (sprot)


VF364_ASFB7 ERCC4 domain-containing protein EP364R (sprot)


M1249_ASFB7 Minor capsid protein M1249L (sprot)


suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity

Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.


VF129_ASFB7 Uncharacterized protein C129R (sprot)


VF717_ASFB7 Uncharacterized protein C717R (sprot)


VF122_ASFB7 Uncharacterized protein C122R (sprot)


VF257_ASFB7 Transmembrane protein C257L (sprot)


PAP1_ASFB7 Putative poly(A) polymerase catalytic subunit (sprot)


H962R_ASFB7 Putative primase C962R (sprot)


FLSO_ASFB7 FAD-linked sulfhydryl oxidase (sprot)


dimethylallyltranstransferase activity

Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.


farnesyltranstransferase activity

Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.


geranyltranstransferase activity

Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.


prenyltransferase activity

Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).


geranylfarnesyl diphosphate synthase activity

Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate.


isoprenoid biosynthetic process

The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


geranyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of geranyl diphosphate.


geranylgeranyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.


farnesyl diphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.


P49_ASFB7 Minor capsid protein p49 (sprot)


VF169_ASFB7 Transmembrane protein B169L (sprot)


VF475_ASFB7 Uncharacterized protein B475L (sprot)


VF385_ASFB7 Zinc finger protein B385R (sprot)


VF117_ASFB7 Uncharacterized protein B117L (sprot)


VF175_ASFB7 Uncharacterized protein B175L (sprot)


VFB66_ASFB7 Transmembrane protein B66L (sprot)


ETFL_ASFB7 Early transcription factor large subunit homolog (sprot)


VF123_ASFB7 Uncharacterized protein CP123L (sprot)


VF312_ASFB7 Uncharacterized protein CP312R (sprot)


RPB5_ASFB7 DNA-directed RNA polymerase RPB5 homolog (sprot)


RPB3_ASFB7 DNA-directed RNA polymerase RPB3-11 homolog (sprot)


VF171_ASFB7 Uncharacterized protein H171R (sprot)


VF124_ASFB7 Uncharacterized protein H124R (sprot)


VF108_ASFB7 Inner membrane protein H108R (sprot)


CAPSP_ASFB7 Penton protein H240R (sprot)


VF509_ASFB7 Putative ATP-dependent RNA helicase QP509L (sprot)


cysteine desulfurase activity

Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine.


iron-sulfur cluster assembly

The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.


VF184_ASFB7 Uncharacterized protein E184L (sprot)


P54_ASFB7 Inner membrane protein p54 (sprot)


microtubule-dependent intracellular transport of viral material towards cell periphery

The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane.


VF423_ASFB7 Uncharacterized protein E423R (sprot)


VF301_ASFB7 Uncharacterized protein E301R (sprot)


VF146_ASFB7 Uncharacterized protein E146L (sprot)


VF199_ASFB7 Inner membrane protein E199L (sprot)


DUTP_ASFB7 Deoxyuridine 5'-triphosphate nucleotidohydrolase (sprot)


E248R_ASFB7 Inner membrane protein pE248R (sprot)


viral inner membrane

The lipid bilayer of a virion contained inside the protein capsid.


APE_ASFB7 Probable AP endonuclease (sprot)


viral DNA repair

The process of restoring viral DNA after damage or errors in replication.


VFE66_ASFB7 host translation inhibitor E66L (sprot)


perturbation by virus of host G0/G1 transition checkpoint

A process in which a virus interferes with the normal execution of the host cell G0/G1 transition checkpoint.


suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity

Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


protein serine/threonine phosphatase inhibitor activity

Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.


protein phosphatase regulator activity

Binds to and modulates the activity of a protein phosphatase.


suppression by virus of host translation initiation

Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein.


regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


protein phosphatase type 1 complex

A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.


DP96R_ASFB7 TBK1 inhibitor DP96R (sprot)


DP60R_ASFB7 Uncharacterized protein DP60R (sprot)


P17_ASFB7 Minor capsid protein p17 (sprot)


H962L_ASFB7 Putative RNA helicase B962L (sprot)


suppression by virus of host adaptive immune response

Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).


ETFS_ASFB7 Early transcription factor large subunit homolog (sprot)


TFNPH_ASFB7 Termination factor NPH-I homolog (sprot)


P10_ASFB7 Structural DNA-binding protein p10 (sprot)


virion nucleoid

The region of a virion in which the nucleic acid is confined.


VF93L_ASFB7 Uncharacterized membrane protein KP93L/DP93R (sprot)


RPB7_ASFB7 DNA-directed RNA polymerase RPB7 homolog (sprot)


A0A8E7PDY2_9VIRU Movement protein TGB2 (trembl)


A0A8E7PE05_9VIRU Movement protein TGBp3 (trembl)


A0A8E7PEB2_9VIRU Capsid protein (trembl)


A0A8E7PFN3_9VIRU Triple gene block protein 1 (trembl)


A0A8E7UE35_9VIRU RNA-dependent RNA polymerase (trembl)


A0A8D9PGS6_9RHAB RNA-directed RNA polymerase (trembl)


D1GV13_9GEMI Replication enhancer (trembl)


D1GV14_9GEMI Transcriptional activator protein (trembl)


D1GV15_9GEMI Replication-associated protein (trembl)


E5AZV9_9VIRU Replication associated protein (trembl)


Q9DXI0_9GEMI Replication-associated protein (trembl)


Q9DXI1_9GEMI Transcriptional activator protein (trembl)


Q9DXI2_9GEMI Replication enhancer (trembl)


Q287B9_NPVAS Ribonucleoside-diphosphate reductase (trembl)


viral occlusion body

A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host.


2',3'-cyclic GMP-AMP binding

Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages.


structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.


protein tag activity

A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.


modification-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.


Q287E1_NPVAS Late expression factor 11 (trembl)


Q287H2_NPVAS DNA-directed DNA polymerase (trembl)


protein autoubiquitination

The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.


Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.


regulation of DNA repair

Any process that modulates the frequency, rate or extent of DNA repair.


Q287M5_NPVAS ribonucleoside-diphosphate reductase (trembl)


Q287N1_NPVAS Alkaline exonuclease (trembl)


fibroblast growth factor receptor binding

Binding to a fibroblast growth factor receptor (FGFR).


growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.


positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.


positive regulation of cell population proliferation

Any process that activates or increases the rate or extent of cell proliferation.


fibroblast growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.


positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).


regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.


Q287P4_NPVAS Ecdysteroid UDP-glucosyltransferase (trembl)


UDP-glycosyltransferase activity

Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.


F4ZCK0_9VIRU Envelopment polyprotein (trembl)


F4ZCK1_9VIRU RNA-directed RNA polymerase L (trembl)


modulation by symbiont of host protein ubiquitination

Any process by which a symbiont increases or decreases ubiquitination of target proteins of a host organism.


A0A220IGE2_9PAPI Replication protein E1 (trembl)


A0A220IGE4_9PAPI Minor capsid protein L2 (trembl)


microtubule-dependent intracellular transport of viral material towards nucleus

The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules.


transport of viral material towards nucleus

The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane.


host cell endosome

A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation.


A0A220IGE5_9PAPI Regulatory protein E2 (trembl)


A0A220IGF5_9PAPI Major capsid protein L1 (trembl)


T=7 icosahedral viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres.


protein domain specific binding

Binding to a specific domain of a protein.


A0A220IGE7_9PAPI Regulatory protein E2 (trembl)


A0A220IGE8_9PAPI Replication protein E1 (trembl)


A0A220IGG0_9PAPI Minor capsid protein L2 (trembl)


A0A220IGG3_9PAPI Major capsid protein L1 (trembl)


A0A0K1RL37_9CIRC Putative replication initiation protein (Fragment) (trembl)


A0A3G6V9C9_9CLOS ORF1a polyprotein (trembl)


A0A0M5L4E9_9VIRU RNA-directed RNA polymerase L (trembl)


A8QZ16_9VIRU Envelopment polyprotein (trembl)


VGA4_ALHV1 Uncharacterized gene A4 protein (sprot)


DNBI_ALHV1 Major DNA-binding protein (sprot)


TRM1_ALHV1 Tripartite terminase subunit 1 (sprot)


viral DNA genome packaging

The packing of viral DNA into a capsid.


GB_ALHV1 Envelope glycoprotein B (sprot)


host cell endosome membrane

The lipid bilayer surrounding a host cell endosome.


DPOL_ALHV1 DNA polymerase catalytic subunit (sprot)


VGA5_ALHV1 G-protein coupled receptor A5 (sprot)


G protein-coupled receptor activity

Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


G protein-coupled receptor signaling pathway

The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.


SCAF_ALHV1 Capsid scaffolding protein (sprot)


viral release from host cell

The dissemination of mature viral particles from a host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane.


CVC2_ALHV1 Capsid vertex component 2 (sprot)


viral genome packaging

The encapsulation of the viral genome within the capsid.


TMP biosynthetic process

The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate.


GH_ALHV1 Envelope glycoprotein H (sprot)


T=16 icosahedral viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres.


TRX2_ALHV1 Triplex capsid protein 2 (sprot)


VG27_ALHV1 Uncharacterized gene 27 protein (sprot)


TRM3_ALHV1 Tripartite terminase subunit 3 (sprot)


CVC1_ALHV1 Capsid vertex component 1 (sprot)


CEP2_ALHV1 Cytoplasmic envelopment protein 2 (sprot)


viral tegument

A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically.


VG36_ALHV1 Putative tyrosine kinase 36 (sprot)


protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.


non-membrane spanning protein tyrosine kinase activity

Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.


AN_ALHV1 Shutoff alkaline exonuclease (sprot)


induction by virus of catabolism of host mRNA

The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA).


CEP3_ALHV1 Cytoplasmic envelopment protein 3 (sprot)


viral budding from Golgi membrane

A viral budding that starts with formation of a membrane curvature in the host Golgi membrane.


GM_ALHV1 Envelope glycoprotein M (sprot)


host cell nuclear inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope.


VG40_ALHV1 Uncharacterized gene 40 protein (sprot)


CEP1_ALHV1 Cytoplasmic envelopment protein 1 (sprot)


HELI_ALHV1 DNA replication helicase (sprot)


UNG_ALHV1 Uracil-DNA glycosylase (sprot)


GL_ALHV1 Envelope glycoprotein L (sprot)


BRLF1_ALHV1 Putative transcription activator BRLF1 homolog (sprot)


VGA7_ALHV1 Putative C-type lectin protein A7 (sprot)


VGA8_ALHV1 Uncharacterized gene A8 protein (sprot)


GN_ALHV1 Envelope glycoprotein N (sprot)


DUT_ALHV1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (sprot)


dUTP metabolic process

The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate.


TEG7_ALHV1 Tegument protein UL51 homolog (sprot)


DNA primase activity

Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.


DNA replication, synthesis of RNA primer

The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.


bidirectional double-stranded viral DNA replication

A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions.


IE63_ALHV1 Immediate-early phosphoprotein 57 (sprot)


VG59_ALHV1 DNA polymerase processivity factor (sprot)


RIR2_ALHV1 Ribonucleoside-diphosphate reductase small subunit (sprot)


viral latency

The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate.


release from viral latency

The process by which a virus begins to replicate following a latency replication decision (switch).


RIR1_ALHV1 Ribonucleoside-diphosphate reductase large subunit (sprot)


TRX1_ALHV1 Triplex capsid protein 1 (sprot)


ITP_ALHV1 Inner tegument protein (sprot)


LTP_ALHV1 Large tegument protein deneddylase (sprot)


SCP_ALHV1 Small capsomere-interacting protein (sprot)


UL49_ALHV1 Uncharacterized gene 66 protein (sprot)


NEC2_ALHV1 Nuclear egress protein 2 (sprot)


TRM2_ALHV1 Tripartite terminase subunit 2 (sprot)


UL32_ALHV1 Packaging protein UL32 homolog (sprot)


NEC1_ALHV1 Nuclear egress protein 1 (sprot)


viral budding from nuclear membrane

A viral budding that starts with formation of a membrane curvature in the host nuclear membrane.


exit of virus from host cell nucleus by nuclear egress

The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm.


VP75_ALHV1 Probable membrane antigen 75 (sprot)


intracellular transport of virus

The directed movement of a virus, or part of a virus, within the host cell.


VGA9_ALHV1 Putative apoptosis regulator A9 (sprot)


VGA10_ALHV1 Uncharacterized gene A10 protein (sprot)


VGA2_ALHV1 Uncharacterized protein A2 (sprot)


VP03_ALHV1 Probable tegument protein antigen 3 (sprot)


SEMA_ALHV1 Semaphorin-like protein A3 (sprot)


integrin binding

Binding to an integrin.


semaphorin receptor binding

Binding to a semaphorin receptor.


chemorepellent activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.


integrin-mediated signaling pathway

The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


axon guidance

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.


positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.


positive regulation of axon extension

Any process that activates or increases the frequency, rate or extent of axon extension.


negative regulation of axon extension involved in axon guidance

Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.


regulation of inflammatory response

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.


positive regulation of macrophage cytokine production

Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


semaphorin-plexin signaling pathway

The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.


A0A2Z5CJA2_9VIRU Replication associated protein (trembl)


A0A2Z5CI32_9VIRU Replication-associated protein (trembl)


A0A2Z5CK60_9VIRU Replication-associated protein (trembl)


MEM_GOGV Putative membrane protein (sprot)


suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity

Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E).


L_GOGV RNA-directed RNA polymerase L (sprot)


cap snatching

A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.


viral replication complex

Specific locations and structures in the virus infected cell involved in replicating the viral genome.


NS2_ADVG Non-structural protein NS2 (sprot)


NS3_ADVG Non-structural protein NS3 (sprot)


A0A451G5G8_9RHAB RNA-directed RNA polymerase (trembl)


A0A0C5GVW6_9VIRU Capsid protein (trembl)


A0A0C5GWS6_9VIRU Movement protein TGBp3 (trembl)


A0A0C5H7M3_9VIRU RNA-dependent RNA polymerase (trembl)


Q913Z7_9VIRU Movement protein TGB2 (trembl)


A0A0K0PRX7_9GEMI Replication-associated protein (trembl)


A0A0K0PSZ7_9GEMI Replication-associated protein (trembl)


RDRP_AMVLE RNA-directed RNA polymerase 2a (sprot)


positive stranded viral RNA replication

A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.


A0A1X9PY58_9VIRU Movement protein TGBp3 (trembl)


A0A2U9K4W4_9GEMI Movement protein BC1 (trembl)


A0A2U9K4W6_9GEMI Nuclear shuttle protein (trembl)


X2C677_9GEMI Transcriptional activator protein (trembl)


X2C6Y5_9GEMI Replication-associated protein (trembl)


X2C8Y6_9GEMI Replication enhancer (trembl)


A0A2H5MI89_9VIRU RNA-directed RNA polymerase (trembl)


C0L9E1_9VIRU RNA replication protein (trembl)


C0L9E4_9VIRU Movement protein TGBp3 (trembl)


A0A024A1N5_9RHAB Virion transmembrane glycoprotein G (trembl)


Q65A77_9VIRU RNA-directed RNA polymerase (trembl)


Q65A78_9VIRU Putative coat protein (trembl)


A0A0U1UZ37_9ALPC Spike glycoprotein (trembl)


receptor-mediated virion attachment to host cell

The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.


A0A0U1WHF8_9ALPC Membrane protein (trembl)


A0A0U1WHG4_9ALPC ORF1ab polyprotein (trembl)


RNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.


omega peptidase activity

Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes.


5'-3' DNA helicase activity

Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis.


A0A0U1WHG6_9ALPC Uncharacterized protein (trembl)


A0A0U1WJX0_9ALPC Small envelope protein (trembl)


A0A6G9LUF7_9POLY Minor capsid protein VP2 (trembl)


A0A6G9LUG9_9POLY Large T antigen (trembl)


A0A6G9LWU8_9POLY Small T antigen (trembl)


A0A6G9LXA2_9POLY Viral protein 1 (trembl)


A0A5J6XVL7_9POLY Middle T antigen (trembl)


K7QJJ1_9POLY Capsid protein VP1 (trembl)


K7QKH3_9POLY Minor capsid protein (trembl)


Q3V6G4_9VIRU Movement protein TGBp3 (trembl)


Q3V6G5_9VIRU Triple gene block protein 2 (trembl)


Q3V6G6_9VIRU Triple gene block protein 1 (trembl)


Q3V6G7_9VIRU RNA replication protein (trembl)


Q2TJB0_9VIRU Triple gene block 1 protein 26k (trembl)


Q2TJB1_9VIRU RNA replication protein (trembl)


Q52Z67_9VIRU Movement protein TGBp3 (trembl)


Q4GZI5_9GEMI Replication-associated protein (trembl)


Q4GZI6_9GEMI Transcriptional activator protein (trembl)


Q4GZI7_9GEMI Replication enhancer (trembl)


A0A146HTD0_9VIRU Putative coat protein (trembl)


A0A146HTF4_9VIRU RNA-directed RNA polymerase (trembl)


A0A076L0Y3_9VIRU RNA-dependent RNA polymerase (trembl)


Q65A75_9VIRU RNA-dependent RNA polymerase (trembl)


Q65A76_9VIRU Putative coat protein (trembl)


A0A1S5SHT7_9VIRU RNA-directed RNA polymerase L (trembl)


A0A1S5SHT8_9VIRU Envelopment polyprotein (trembl)


V5V0U1_9VIRU Putative triple gene block protein 1 (trembl)


V5V1N5_9VIRU Movement protein TGBp3 (trembl)


V5V1R1_9VIRU RNA replication protein (trembl)


V5V1S7_9VIRU Putative triple gene block protein 2 (trembl)


V5V388_9VIRU Putative coat protein (trembl)


A0A0U2HZR0_9VIRU Putative NTPase (trembl)


A0A0U2I066_9VIRU Ribonucleotide reductase large subunit (trembl)


A0A0U2JD16_9VIRU Major capsid protein (trembl)


A0A0U2JDP8_9VIRU Transmembrane protein (trembl)


A0A0U2JP15_9VIRU IMV membrane protein (trembl)


A0A0U2JPS1_9VIRU dUTP diphosphatase (trembl)


A0A0U2K4Q0_9VIRU Neurofilament triplet H1-like protein (trembl)


A0A0U2K4U5_9VIRU Orf20-like protein (trembl)


A0A0U2K695_9VIRU Uncharacterized protein (trembl)


A0A0U2K6G7_9VIRU ElF2a-like protein (trembl)


ribosome binding

Binding to a ribosome.


A0A0U2Q8X2_9VIRU Cytosine DNA methyltransferase (trembl)


A0A0U2QAJ0_9VIRU Putative LITAF/PIG7 membrane-associated motif in LPS-induced tumor necrosis factor alpha factor (trembl)


cytoplasmic side of lysosomal membrane

The side (leaflet) of the lysosomal membrane that faces the cytoplasm.


A0A0U2QB90_9VIRU L-protein-like protein (trembl)


A0A0U2QD11_9VIRU Transmembrane protein (trembl)


A0A0U2QD42_9VIRU ribonucleoside-diphosphate reductase (trembl)


A0A0U2QFB5_9VIRU Transmembrane protein (trembl)


A0A0U2QHL9_9VIRU Putative tyrosine kinase (trembl)


A0A0U2QI73_9VIRU Putative phosphotransferase (trembl)


A0A0U2R6L5_9VIRU Uncharacterized protein (trembl)


A0A0U2R6P5_9VIRU Putative D5 family NTPase/ATPase (trembl)


A0A0U2R7T3_9VIRU Putative myeloid cell leukemia protein (trembl)


A0A0U2RDY1_9VIRU Transmembrane protein (trembl)


A0A0U2RDZ5_9VIRU Putative hydrolase of the metallo-beta-lactamase superfamily (trembl)


A0A0U2RE09_9VIRU Protein kinase domain-containing protein (trembl)


A0A0U2RGH4_9VIRU Holliday junction resolvase (trembl)


A0A0U2RGT0_9VIRU Putative deoxynucleoside kinase (trembl)


A0A0U2RGW3_9VIRU Transmembrane protein (trembl)


A0A0U2RNN4_9VIRU Transcription elongation factor II (trembl)


A0A0U2RNW3_9VIRU Putative myristylated membrane protein (trembl)


A0A0U2RP96_9VIRU Sulfhydryl oxidase (trembl)


A0A0U2RPC8_9VIRU Helicase-like protein (trembl)


A0A0U2RPH2_9VIRU Putative replicating factor (trembl)


A0A0U2RQ57_9VIRU DNA-directed RNA polymerase subunit beta (trembl)


A0A0U2RR20_9VIRU Putative DNA repair protein RAD2 (trembl)


A0A0U2RTZ9_9VIRU Putative ATPase-dependent protease (trembl)


A0A0U2RU13_9VIRU DNA-directed DNA polymerase (trembl)


A0A0U2RUR7_9VIRU p8.141C-like protein (trembl)


A0A0U2RVD0_9VIRU Uncharacterized protein (trembl)


A0A0U2S082_9VIRU DNA-directed RNA polymerase subunit (trembl)


A0A0U2S0A0_9VIRU thymidylate synthase (trembl)


I1W5T2_9VIRU Putative viral replicase (trembl)


I1W5T3_9VIRU Triple gene block protein 1 (trembl)


I1W5T4_9VIRU Movement protein TGB2 (trembl)


I1W5T5_9VIRU Movement protein TGBp3 (trembl)


I1W5T7_9VIRU RNA silencing suppressor (trembl)


Q997A3_9BROM RNA-directed RNA polymerase 2a (trembl)


Q997A4_9BROM Replication protein 1a (trembl)


A0A1P8YT73_9VIRU Replication associated protein (trembl)


A0A1P8YT80_9VIRU Replication-associated protein (trembl)


Y014_AMEPV Uncharacterized leucine-rich repeat-containing protein AMV014/Q3 (sprot)


positive regulation of Ras protein signal transduction

Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.


NTP1_AMEPV Nucleoside triphosphatase I (sprot)


A28_AMEPV Envelope protein A28 homolog (sprot)


I7_AMEPV Core protease I7 homolog (sprot)


P87507_AMEPV DNA topoisomerase I (trembl)


transcription regulator complex

A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.


Q9EMH5_AMEPV Uracil-DNA glycosylase (trembl)


Q9EMI5_AMEPV DNA-directed RNA polymerase 147 kDa polypeptide (trembl)


NMT_AMEPV Putative glycylpeptide N-tetradecanoyltransferase (sprot)


Q9EMJ6_AMEPV Probable AP endonuclease (trembl)


Q9EMK1_AMEPV Viral late gene transcription factor 3 (trembl)


Q9EMP6_AMEPV Serine/threonine-protein kinase (trembl)


Q9EMQ2_AMEPV Virion core protein 4b (trembl)


Q9EMR4_AMEPV mRNA-capping enzyme catalytic subunit (trembl)


lipid transporter activity

Enables the directed movement of lipids into, out of or within a cell, or between cells.


ABC-type transporter activity

Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.


Q9EMT4_AMEPV Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (trembl)


Q9EMT5_AMEPV Sulfhydryl oxidase (trembl)


Q9EMU4_AMEPV Early transcription factor 82 kDa subunit (trembl)


Q9EMW8_AMEPV RNA helicase NPH-II (trembl)


PTPH_AMEPV Putative tyrosine-protein phosphatase AMV078 (sprot)


Q9EMX8_AMEPV Entry-fusion complex protein OPG086 (trembl)


extracellular matrix

A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.


Q9EMY3_AMEPV DNA-directed RNA polymerase (trembl)


Q9EMY9_AMEPV Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (trembl)


Q9EMZ5_AMEPV RNA polymerase-associated transcription-specificity factor RAP94 (trembl)


Q9EN10_AMEPV Poly(A) polymerase catalytic subunit (trembl)


Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine.


Q9EN44_AMEPV Deoxyuridine 5'-triphosphate nucleotidohydrolase (trembl)


nicotinamide riboside transmembrane transporter activity

Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other.


nicotinamide riboside transport

The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


A1YZN4_9ALPH Tegument/envelope protein (trembl)


A1YZN7_9ALPH Tripartite terminase subunit 2 (trembl)


A1YZN8_9ALPH Nuclear egress protein 2 (trembl)


A2TIU6_9ALPH Capsid vertex component 1 (trembl)


A2TIU8_9ALPH Triplex capsid protein 2 (trembl)


A2TIV0_9ALPH Envelope protein UL20 (trembl)


host cell nuclear membrane

Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space.


A2TIV6_9ALPH Small capsomere-interacting protein (trembl)


A2TIV8_9ALPH Capsid scaffolding protein (trembl)


A2TIW0_9ALPH Envelope glycoprotein B (trembl)


A3RMA2_9ALPH DNA helicase/primase complex-associated protein (trembl)


A3RMA4_9ALPH Envelope glycoprotein M (trembl)


A3RMA5_9ALPH Envelope glycoprotein L (trembl)


A4GRJ3_9ALPH Envelope glycoprotein H (trembl)


A4GRJ6_9ALPH Capsid vertex component 2 (trembl)


A4GRK2_9ALPH Nuclear egress protein 1 (trembl)


A4GRK3_9ALPH Packaging protein UL32 (trembl)


A4ZX80_9ALPH Tegument protein VP22 (trembl)


A4ZX81_9ALPH Envelope glycoprotein (trembl)


A4ZX82_9ALPH Deoxyuridine 5'-triphosphate nucleotidohydrolase (trembl)


A5A413_9ALPH Tegument serine/threonine protein kinase (trembl)


A5A414_9ALPH Tegument protein UL14 (trembl)


A5A417_9ALPH Regulatory protein US1 (trembl)


A7L873_9ALPH Tegument protein UL51 (trembl)


A9QXU7_9ALPH Envelope glycoprotein K (trembl)


fusion of viral membrane with host outer nuclear membrane

Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit.


positive regulation of syncytium formation by virus

The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


host cell nuclear matrix

The dense fibrillar network lying on the inner side of the host nuclear membrane.


B4XS31_9ALPH Envelope glycoprotein D (trembl)


B5LRM7_9ALPH Uracil-DNA glycosylase (trembl)


B6E8Y9_9ALPH Tegument protein UL37 (trembl)


B6E8Z0_9ALPH Triplex capsid protein 1 (trembl)


B6E8Z2_9ALPH Ribonucleoside-diphosphate reductase small subunit (trembl)


deNEDDylase activity

An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.


C6ZD01_9ALPH DNA polymerase processivity factor (trembl)


C6ZD04_9ALPH Ribonucleoside-diphosphate reductase large subunit (trembl)


C6ZD24_9ALPH Major capsid protein (trembl)


C6ZD35_9ALPH Replication origin-binding protein (trembl)


C6ZD38_9ALPH Envelope glycoprotein E (trembl)


anchoring junction

A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.


E1U2A6_9ALPH Envelope glycoprotein I (trembl)


E1U2B0_9ALPH Multifunctional expression regulator (trembl)


E6Y393_9ALPH DNA replication helicase (trembl)


E6Y398_9ALPH Tegument protein UL47 (trembl)


E6Y399_9ALPH Alpha trans-inducing protein (trembl)


H9DUZ2_9ALPH Virion host shutoff protein (trembl)


H9DV04_9ALPH Major DNA-binding protein (trembl)


H9DV05_9ALPH Tripartite terminase subunit 1 (trembl)


H9DV17_9ALPH Tripartite terminase subunit 3 (trembl)


A0A088SG43_9GEMI Transcriptional activator protein (trembl)


A0A088SGC3_9GEMI Replication-associated protein (trembl)


A0A088SGJ4_9GEMI Capsid protein (trembl)


A0A088T1G4_9GEMI Replication enhancer (trembl)


A0A140GL60_9VIRU Virion-associated protein (trembl)


A0A140GL62_9VIRU Enzymatic polyprotein (trembl)


RNA-directed DNA polymerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.


aspartic-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.


RNA-templated DNA biosynthetic process

A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.


A0A140GL63_9VIRU Transactivator/viroplasmin protein (trembl)


Q2Q474_9TOMB RNA-directed RNA polymerase (trembl)


W5RNT1_9CIRC Replication-associated protein (trembl)


W6JIJ4_9POXV Leucine-rich repeat gene family protein (trembl)


W6JIK4_9POXV Uncharacterized protein (trembl)


W6JIL4_9POXV Nicotinamide riboside kinase 1 (trembl)


W6JIL6_9POXV Uncharacterized protein (trembl)


W6JIM7_9POXV Putative membrane protein (trembl)


W6JIP4_9POXV Putative calcium binding protein (trembl)


W6JIQ1_9POXV IMV membrane protein (trembl)


W6JIR8_9POXV Putative late transcription factor VLTF-2 (trembl)


W6JIS3_9POXV Protein kinase domain containing protein (trembl)


W6JIS6_9POXV Holliday junction resolvase (trembl)


W6JIS7_9POXV Putative core protein (trembl)


W6JIT4_9POXV Superoxide dismutase (trembl)


W6JIT6_9POXV Putative myristylated membrane protein (trembl)


W6JIT8_9POXV Uncharacterized protein (trembl)


W6JIT9_9POXV Uncharacterized protein (trembl)


W6JIU0_9POXV Tryptophan-rich sensory protein (trembl)


W6JIU3_9POXV Uncharacterized protein (trembl)


W6JIU5_9POXV Precursor p4a of core protein 4a (trembl)


W6JIU6_9POXV Putative glycosyl transferase (trembl)


W6JIU7_9POXV DNA helicase, transcriptional elongation (trembl)


W6JIV1_9POXV Reverse transcriptase (trembl)


W6JIV2_9POXV Serin/threonine kinase like (trembl)


W6JIV8_9POXV Zinc-dependent metalloprotease (trembl)


collagen catabolic process

The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.


W6JIW0_9POXV Serine/threonine-protein kinase 2 (trembl)


W6JIW3_9POXV Putative viral membrane protein (trembl)


W6JIW7_9POXV Triacylglycerol lipase (trembl)


W6JIW8_9POXV Putative NTP pyrophosphohydrolase mutT motif (trembl)


W6JIX0_9POXV Uncharacterized protein (trembl)


W6JIX9_9POXV Uncharacterized protein (trembl)


W6JIY5_9POXV Capcid protein VP1-like (trembl)


W6JIZ0_9POXV S-S bond formation pathway protein (trembl)


W6JIZ4_9POXV Putative glycoprotein B (trembl)


W6JIZ6_9POXV Early transcription factor 82 kDa subunit (trembl)


W6JJ01_9POXV Late transcription factor VLTF-3 (trembl)


W6JJ15_9POXV Probable AP endonuclease (trembl)


W6JJ19_9POXV Uncharacterized protein (trembl)


W6JJ26_9POXV Uncharacterized protein (trembl)


W6JJ39_9POXV Putative exonuclease RNase T and DNA polymerase III (trembl)


W6JKS0_9POXV Matrix metalloproteinase (trembl)


W6JKT0_9POXV Putative ATP-binding cassette transporter (trembl)


W6JKU0_9POXV IMV membrane protein involved in fusion and entry (trembl)


W6JKU5_9POXV Uncharacterized protein (trembl)


W6JKV6_9POXV Uncharacterized protein (trembl)


W6JKY2_9POXV DNA-directed RNA polymerase (trembl)


W6JKY5_9POXV IMV membrane protein (trembl)


W6JKZ1_9POXV Uncharacterized protein (trembl)


W6JKZ5_9POXV Putative early transcription factor small subunit (trembl)


W6JKZ6_9POXV Putative ser/thr protein kinase (trembl)


W6JKZ9_9POXV G-protein coupled receptor Mth2-like (trembl)


W6JL01_9POXV Uncharacterized protein (trembl)


W6JL07_9POXV mRNA-capping enzyme catalytic subunit (trembl)


W6JL13_9POXV RNA polymerase-associated transcription-specificity factor RAP94 (trembl)


W6JL18_9POXV Ubiquitin/ribosomal protein (trembl)


ribosome

An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.


W6JL25_9POXV RNA helicase NPH-II (trembl)


W6JL30_9POXV Putative poly(A) polymerase small subunit (trembl)


W6JL37_9POXV DNA-directed RNA polymerase beta chain (trembl)


W6JL47_9POXV Peritrophin-A domain containing protein (trembl)


W6JL61_9POXV Entry-fusion complex protein OPG086 (trembl)


W6JL64_9POXV DNA-directed RNA polymerase 147 kDa polypeptide (trembl)


W6JL71_9POXV Zinc-dependent metalloprotease (trembl)


W6JL79_9POXV Uncharacterized protein (trembl)


W6JL81_9POXV Uncharacterized protein (trembl)


W6JL83_9POXV Phosphatidic acid phosphatase type 2 (trembl)


phosphatidate phosphatase activity

Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.


phospholipid dephosphorylation

The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


W6JLB2_9POXV Poxvirus myristoylprotein (trembl)


W6JLB8_9POXV Metallophosphoesterase domain-containing protein (trembl)


cell wall modification

The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.


W6JLC2_9POXV Putative myristylated membrane protein (trembl)


W6JLD1_9POXV Translation elongation factor eEF-3 like (trembl)


W6JLD5_9POXV Uncharacterized protein (trembl)


W6JLG4_9POXV Putative NAD+ dependent DNA ligase (trembl)


W6JLH1_9POXV Cation transport ATPase (trembl)


W6JLH5_9POXV Uncharacterized protein (trembl)


W6JLI2_9POXV Translation initiation factor elF-4e (trembl)


W6JLI8_9POXV Uncharacterized protein (trembl)


W6JLJ1_9POXV Virion core protein 4b (trembl)


W6JLK0_9POXV Poly(A) polymerase catalytic subunit (trembl)


W6JLK9_9POXV Ubiquitin-conjugating enzyme E2 (trembl)


W6JLL8_9POXV PPM-type phosphatase domain-containing protein (trembl)


W6JLM1_9POXV Uncharacterized protein (trembl)


W6JLM5_9POXV Putative NTPase/helicase (trembl)


W6JLN7_9POXV glycylpeptide N-tetradecanoyltransferase (trembl)


W6JLN8_9POXV Leucine rich repeat gene family protein (trembl)


W6JLQ8_9POXV Zinc-dependent metalloprotease (trembl)


W6JPJ3_9POXV Uncharacterized protein (trembl)


W6JPJ7_9POXV Uracil-DNA glycosylase (trembl)


W6JPJ9_9POXV Putative mRNA capping enzyme small subunit (trembl)


W6JPK2_9POXV Uncharacterized protein (trembl)


W6JPK4_9POXV Nucleoside triphosphatase I (trembl)


W6JPK8_9POXV 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (trembl)


W6JPK9_9POXV Uncharacterized protein (trembl)


W6JPL0_9POXV Virion membrane protein (trembl)


W6JPL3_9POXV Leucine-rich repeat protein (trembl)


W6JPL4_9POXV Endonuclease/exonuclease/phosphatase domain-containing protein (trembl)


W6JPL5_9POXV Uncharacterized protein (trembl)


W6JPL7_9POXV Uncharacterized protein (trembl)


W6JPM1_9POXV Uncharacterized protein (trembl)


W6JPM3_9POXV Uncharacterized protein (trembl)


W6JPM4_9POXV ATP-dependent DNA ligase (trembl)


W6JPM5_9POXV Nucleopolyhedrovirus p26 protein (trembl)


W6JPM6_9POXV Putative vaccinia G1L metaloprotease (trembl)


W6JPM9_9POXV Uncharacterized protein (trembl)


W6JPN2_9POXV Uncharacterized protein (trembl)


W6JPN3_9POXV Uncharacterized protein (trembl)


W6JPN4_9POXV Gamma-glutamyl cyclotransferase like (trembl)


W6JPN8_9POXV Peptidase M10 metallopeptidase domain-containing protein (trembl)


A0A291NVX1_9VIRU Envelopment polyprotein (trembl)


A0A291NVX5_9VIRU RNA-directed RNA polymerase L (trembl)


A0A7D9MVR7_9VIRU Envelopment polyprotein (trembl)


A0A7D9MVR8_9VIRU RNA-directed RNA polymerase L (trembl)


W8QE04_9VIRU Uncharacterized protein (trembl)


W8QE16_9VIRU DNA-directed RNA polymerase (trembl)


W8QE20_9VIRU Membrane-type matrix metallopeptidase-1 (trembl)


W8QE39_9VIRU Type III restriction enzyme, res subunit:DEAD/DEAH box helicase, N-terminal (trembl)


W8QE45_9VIRU Lipid membrane protein (trembl)


W8QE57_9VIRU ribonucleoside-diphosphate reductase (trembl)


W8QE71_9VIRU RuvC-like Holliday junction resolvase (trembl)


W8QE83_9VIRU 5'-3' exoribonuclease 1 (trembl)


W8QE87_9VIRU Resolvase HTH domain-containing protein (trembl)


W8QEY7_9VIRU C3H1-type domain-containing protein (trembl)


W8QF03_9VIRU Putative tyrosine protein kinase (trembl)


W8QF08_9VIRU Ribonucleoside-diphosphate reductase large subunit (trembl)


W8QF12_9VIRU DNA-directed DNA polymerase (trembl)


W8QF27_9VIRU Transcription factor TFIIB cyclin-like domain-containing protein (trembl)


W8QF41_9VIRU Uncharacterized protein (trembl)


W8QF60_9VIRU DNA ligase (NAD(+)) (trembl)


siRNA binding

Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.


regulation of regulatory ncRNA processing

Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing.


RISC-loading complex

A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.


W8QF75_9VIRU DNA repair exonuclease SbcCD D subunit (trembl)


DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.


W8QMX2_9VIRU Uncharacterized protein (trembl)


W8QMY0_9VIRU OTU domain-containing protein (trembl)


W8QMY5_9VIRU Uncharacterized protein (trembl)


W8QMZ0_9VIRU TFIIS-type domain-containing protein (trembl)


W8QMZ3_9VIRU Putative myristylated membrane protein (trembl)


W8QMZ6_9VIRU Serine/threonine-protein kinase pim-2-like protein (trembl)


W8QN00_9VIRU Flap structure-specific endonuclease (trembl)


W8QN18_9VIRU SWI/SNF2 family helicase (trembl)


W8QN22_9VIRU Uncharacterized protein (trembl)


W8QN39_9VIRU DNA-directed RNA polymerase subunit (trembl)


W8QN42_9VIRU Uncharacterized protein (trembl)


W8QN45_9VIRU Histone H2A/H2B/H3 domain-containing protein (trembl)


W8QRE1_9VIRU RING-type domain-containing protein (trembl)


W8QRF9_9VIRU DNA binding/packing protein (trembl)


W8QRH5_9VIRU thymidylate synthase (trembl)


W8QRK5_9VIRU High mobility group protein-like protein (trembl)


W8R9J9_9VIRU D5 family helicase-primase (trembl)


W8R9K4_9VIRU Sulfhydryl oxidase (trembl)


W8R9M2_9VIRU Papain-like proteinase (trembl)


W8R9P9_9VIRU Uncharacterized protein (trembl)


W8R9R8_9VIRU dUTP diphosphatase (trembl)


W8R9S2_9VIRU Haloacid dehalogenase-like hydrolases (trembl)


W8R9T0_9VIRU SWIB complex BAF60b domain-containing protein (trembl)


RNA polymerase I cis-regulatory region sequence-specific DNA binding

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element).


transcription initiation at RNA polymerase I promoter

A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I.


nucleolar large rRNA transcription by RNA polymerase I

The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.


W8R9T5_9VIRU DNA topoisomerase 2 (trembl)


W8R9U1_9VIRU Putative deoxynucleotide monophosphate kinase (trembl)


A0A1Y0KBX0_9MONO Matrix protein (trembl)


A0A1Y0KC98_9MONO Fusion glycoprotein F0 (trembl)


A0A1Y0KCC6_9MONO RNA-directed RNA polymerase L (trembl)


exo-alpha-(2->3)-sialidase activity

Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates.


exo-alpha-(2->6)-sialidase activity

Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates.


exo-alpha-(2->8)-sialidase activity

Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates.


Q1G404_NPVAP Late expression factor 11 (trembl)


Q1HGW8_NPVAP Occlusion-derived virus envelope protein E26 (trembl)


Q1HGX4_NPVAP Envelope F protein (trembl)


Q1HGX8_NPVAP Uncharacterized protein (trembl)


Q1HGY1_NPVAP Uncharacterized protein (trembl)


Q1HGZ1_NPVAP Transcription regulator (trembl)


Q1HGZ3_NPVAP Global transactivator (trembl)


Q1HGZ9_NPVAP DNA-directed RNA polymerase (trembl)


Q1HH00_NPVAP RRM domain-containing protein (trembl)


Q1HH13_NPVAP Per os infection factor-6 (trembl)


Q1HH22_NPVAP Very-late factor 1 (trembl)


Q1HH30_NPVAP Major viral capsid protein (trembl)


Q1HH31_NPVAP Late expression factor 4 (trembl)


Q1HH35_NPVAP Occlusion-derived virus envelope protein E25 (trembl)


Q1HH49_NPVAP Chitin-binding protein 2 (trembl)


Q1HH55_NPVAP Per os infection factor-3 (trembl)


Q1HH61_NPVAP Uncharacterized protein (trembl)


Q1HH62_NPVAP 3' repair exonuclease (trembl)


Q1HH67_NPVAP Viral capsid protein (trembl)


Q1HH71_NPVAP Alkaline exonuclease (trembl)


Q1HH84_NPVAP Chitin-binding protein (trembl)


calmodulin-dependent protein kinase activity

Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.


calmodulin binding

Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.


cellular response to oxidative stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


actin binding

Binding to monomeric or multimeric forms of actin, including actin filaments.


Q5I7H1_NPVAP Occlusion-derived virus envelope-56 protein (trembl)


Q5MAH3_NPVAP Late expression factor 3 (trembl)


Q5Y4P0_NPVAP Protein tyrosine phosphatase 1 (trembl)


Q5Y4P2_NPVAP Protein tyrosine phosphatase 2 (trembl)


Q5Y4P5_NPVAP Late expression factor 2 (trembl)


Q7T5F9_NPVAP Late expression factor 5 (trembl)


A0A2V0A0Q4_9VIRU RNA-dependent RNA polymerase (trembl)


A0A8D9PGZ9_9RHAB RNA-directed RNA polymerase (trembl)


D9U543_9VIRU RNA-directed RNA polymerase (trembl)


A0A218KIR8_9VIRU ORF1/ORF2 fusion protein (trembl)


G8XU73_9BETA Membrane protein A1 (trembl)


G8XU86_9BETA Membrane protein UL14 (trembl)


G8XU87_9BETA Membrane protein A13 (trembl)


immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.


G8XU89_9BETA Membrane protein A14 (trembl)


signaling receptor binding

Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


peptide antigen binding

Binding to an antigen peptide.


antigen processing and presentation of endogenous peptide antigen via MHC class Ib

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.


G8XU93_9BETA Membrane protein A18 (trembl)


G8XUA7_9BETA Tegument protein pp150 (trembl)


G8XUA8_9BETA Envelope glycoprotein UL33 (trembl)


C-C chemokine receptor activity

Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.


C-C chemokine binding

Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.


positive regulation of cytosolic calcium ion concentration

Any process that increases the concentration of calcium ions in the cytosol.


calcium-mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.


cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


G8XUB2_9BETA Envelope glycoprotein UL37 (trembl)


G8XUB4_9BETA Membrane glycoprotein UL40 (trembl)


G8XUB5_9BETA Membrane protein A20A (trembl)


G8XUB9_9BETA DNA polymerase processivity factor (trembl)


G8XUC0_9BETA Ribonucleotide reductase subunit 1 (trembl)


G8XUC1_9BETA Capsid triplex subunit 1 (trembl)


G8XUC2_9BETA Tegument protein UL37 (trembl)


G8XUC3_9BETA Large tegument protein (trembl)


G8XUC4_9BETA Small capsomere-interacting protein (trembl)


G8XUC6_9BETA Nuclear egress protein 2 (trembl)


G8XUC7_9BETA Tripartite terminase subunit 2 (trembl)


G8XUC8_9BETA Packaging protein UL32 (trembl)


G8XUC9_9BETA Nuclear egress protein 1 (trembl)


G8XUD1_9BETA Envelope glycoprotein B (trembl)


G8XUD2_9BETA Tripartite terminase subunit 1 (trembl)


G8XUD3_9BETA Major DNA-binding protein (trembl)


G8XUD4_9BETA mRNA export factor ICP27 homolog (trembl)


G8XUD6_9BETA Tegument protein UL51 homolog (trembl)


G8XUD7_9BETA Deoxyuridine 5'-triphosphate nucleotidohydrolase (trembl)


G8XUD8_9BETA Envelope glycoprotein N (trembl)


G8XUD9_9BETA Envelope glycoprotein O (trembl)


G8XUE0_9BETA Envelope glycoprotein 24 (Fragment) (trembl)


G8XUE1_9BETA Envelope glycoprotein H (trembl)


G8XUE2_9BETA Nuclear protein UL24 (trembl)


G8XUE3_9BETA Capsid vertex component 2 (trembl)


G8XUE4_9BETA Envelope protein UL78 (trembl)


G8XUE6_9BETA Capsid scaffolding protein (trembl)


G8XUE8_9BETA Tegument protein pp71 (trembl)


G8XUE9_9BETA Tegument protein pp65 (trembl)


G8XUF1_9BETA Triplex capsid protein 2 (trembl)


G8XUF2_9BETA Major capsid protein (trembl)


G8XUF5_9BETA Tripartite terminase subunit 3 (trembl)


G8XUF8_9BETA DNA packaging tegument protein UL17 (trembl)


G8XUG2_9BETA Tegument serine/threonine protein kinase (trembl)


G8XUG4_9BETA Cytoplasmic envelopment protein 3 (trembl)


G8XUG5_9BETA Envelope glycoprotein M (trembl)


G8XUG6_9BETA DNA helicase/primase complex-associated protein (trembl)


G8XUG9_9BETA DNA replication helicase (trembl)


G8XUH0_9BETA Viral interleukin-10 homolog (trembl)


cytokine activity

The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.


regulation of cytokine production

Any process that modulates the frequency, rate, or extent of production of a cytokine.


G8XUH2_9BETA Uracil-DNA glycosylase (trembl)


G8XUH3_9BETA Envelope glycoprotein L (trembl)


entry receptor-mediated virion attachment to host cell

The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that mediates/triggers viral entry by endocytosis/pinocytosis or by inducing fusion/penetration.


G8XUH6_9BETA Membrane glycoprotein UL119 (trembl)


G8XUH7_9BETA Membrane protein A21 (trembl)


positive regulation of cytokine production involved in immune response

Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.


negative regulation of alpha-beta T cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation.


positive regulation of peptidyl-tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.


defense response to Gram-negative bacterium

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.


defense response to Gram-positive bacterium

Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.


positive regulation of T cell migration

Any process that activates or increases the frequency, rate or extent of T cell migration.


G8XUH8_9BETA Membrane protein UL121 (trembl)


G8XUH9_9BETA Regulatory protein IE2 (trembl)


G8XUI0_9BETA Regulatory protein IE1 (trembl)


G8XUI1_9BETA Membrane protein UL124 (trembl)


G8XUI2_9BETA Envelope protein UL128 (trembl)


G8XUI3_9BETA Envelope glycoprotein UL130 (trembl)


G8XUI4_9BETA Envelope protein UL131A (trembl)


G8XUI5_9BETA Envelope glycoprotein UL132 (trembl)


G8XUI6_9BETA Membrane protein UL148 (trembl)


G8XUI8_9BETA Membrane protein A22B (trembl)


G8XUI9_9BETA Membrane protein A23 (trembl)


G8XUJ0_9BETA Membrane protein A24 (trembl)


chemokine activity

The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


G8XUJ3_9BETA Membrane protein A25A (trembl)


G8XUJ4_9BETA Membrane protein A25B (trembl)


G8XUJ5_9BETA Membrane protein A25C (trembl)


G8XUJ6_9BETA Membrane protein A25D (trembl)


G8XUJ7_9BETA Membrane protein A25E (trembl)


G8XUK2_9BETA Membrane protein A28 (trembl)


G8XUK3_9BETA Membrane protein A29 (trembl)


G8XUK5_9BETA Membrane protein A31 (trembl)


G8XUK6_9BETA Membrane protein A32 (trembl)


G8XUL0_9BETA Membrane protein A33 (trembl)


G8XUL2_9BETA Membrane protein A34 (trembl)


G8XUL3_9BETA Membrane protein A35 (trembl)


G8XUL4_9BETA Membrane protein A36 (trembl)


G8XUL5_9BETA Membrane protein A37 (trembl)


G8XUL6_9BETA Membrane protein A38 (trembl)


G8XUL7_9BETA Membrane protein A39 (trembl)


G8XUL8_9BETA Membrane protein A40 (trembl)


G8XUM1_9BETA Membrane protein A43 (trembl)


MHC class I protein binding

Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


G8XUM2_9BETA Membrane protein A44 (trembl)


G8XUM3_9BETA Membrane protein A45 (trembl)


G8XUM4_9BETA Membrane protein A46 (trembl)


A0A9N6YJD9_9VIRU Nucleocapsid protein (Fragment) (trembl)


A0A9N6YJT3_9VIRU Glycoprotein (Fragment) (trembl)


A0A9N6YK18_9VIRU RNA-dependent RNA polymerase (trembl)


A0A5B8HBW2_9VIRU RNA-directed RNA polymerase L (trembl)


A0A0S1MMX4_9VIRU Capsid protein (trembl)


A0A0S1MNC2_9VIRU Capsid protein (trembl)


A0A4D6BMF8_9VIRU Replication-associated protein (trembl)


A0A4D6BNS9_9VIRU Replication-associated protein (trembl)


A0A345GNZ4_9NIDO Replicase polyprotein 1ab (trembl)


A0A345GNZ5_9NIDO Putative structural polyprotein (trembl)


negative stranded viral RNA replication

A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).


RNA-templated viral transcription

A transcription process that uses viral RNA as a template.


A0A2U7PKX3_9VIRU RING finger protein Z (trembl)


viral budding via host ESCRT complex

Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.


viral budding

A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space.


viral budding from plasma membrane

A viral budding that starts with formation of a curvature in the host plasma membrane around which the virion particle assembles.


A0A2U7PVP1_9VIRU Pre-glycoprotein polyprotein GP complex (trembl)


receptor-mediated endocytosis of virus by host cell

Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell.


A0A2U7PZY1_9VIRU RNA-directed RNA polymerase L (trembl)


RDRP_ACLSP RNA-directed RNA polymerase (sprot)


MP_ACLSP Putative movement protein (sprot)


A0A2U8N4S3_9TOMB Readthrough protein (trembl)


A0A2U8N4X5_9TOMB RNA-directed RNA polymerase (trembl)


Q9QGG9_9BROM RNA-directed RNA polymerase 2a (trembl)


Q9QGH0_9BROM Replication protein 1a (trembl)


A0A4D6DD03_9RHAB RNA-directed RNA polymerase (trembl)


A0A4D6DD31_9RHAB Putative glycoprotein (trembl)


MP_ASGVP Probable movement protein (sprot)


RDRP_ASPVP RNA replication polyprotein (sprot)


TGB1_ASPVP Movement and silencing protein TGBp1 (sprot)


TGB2_ASPVP Movement protein TGB2 (sprot)


TGB3_ASPVP Movement protein TGBp3 (sprot)


A0A6C0X2K4_9MONO RNA-directed RNA polymerase (trembl)


A0A6C0X4K5_9MONO Sigma-54 factor interaction domain-containing protein (trembl)


W0UT97_9VIRU RNA silencing suppressor (trembl)


W0UU68_9VIRU Replication-associated polyprotein (trembl)


A0A0F6TGK2_9CIRC Replication-associated protein (trembl)


VNS2_AQRVC Non-structural protein 2 (sprot)


VP7_AQRVC Outer capsid protein VP7 (sprot)


T=13 icosahedral viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres.


viral intermediate capsid

The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions.


VNS5_AQRVC Non-structural protein 5 (sprot)


VP4_AQRVC Outer capsid protein VP4 (sprot)


host cell surface binding

Binding to the surface of a host cell.


VP5_AQRVC Microtubule-associated protein VP5 (sprot)


VNS1_AQRVC Non-structural protein 1 (sprot)


CAPSD_AQRVC Major inner capsid protein VP3 (sprot)


RDRP_AQRVC RNA-directed RNA polymerase VP2 (sprot)


VP1_AQRVC Outer capsid protein VP1 (sprot)


VP1_AQRVG Outer capsid protein VP1 (sprot)


RDRP_AQRVG RNA-directed RNA polymerase VP2 (sprot)


CAPSD_AQRVG Major inner capsid protein VP3 (sprot)


VNS1_AQRVG Non-structural protein 1 (sprot)


VP5_AQRVG Microtubule-associated protein VP5 (sprot)


VP4_AQRVG Outer capsid protein VP4 (sprot)


VNS5_AQRVG Non-structural protein 5 (sprot)


VNS2_AQRVG Non-structural protein 2 (sprot)


VP7_AQRVG Outer capsid protein VP7 (sprot)


A0A1B4ZBZ5_9VIRU RNA-dependent RNA polymerase (trembl)


A0A343FNE1_9ORTO RNA-directed RNA polymerase catalytic subunit (trembl)


A0A343FNE3_9ORTO Hemagglutinin protein (trembl)


A0A345BKA2_9VIRU Replication-associated protein (trembl)


A0A0G2UEF4_9CLOS Minor coat protein (trembl)


A0A0G2UG82_9CLOS RNA-dependent RNA polymerase (Fragment) (trembl)


A0A0G2UMJ8_9CLOS Heat shock protein 70 (trembl)


W1I6K0_9VIRU RNA dependent RNA polymerase (trembl)


A0A068QK28_9VIRU Polynucleotide kinase/ligase (trembl)


A0A068QK35_9VIRU Uncharacterized protein (trembl)


A0A068QK46_9VIRU Sulfhydryl oxidase (trembl)


A0A068QK70_9VIRU Non-specific serine/threonine protein kinase (trembl)


A0A068QK77_9VIRU Putative helicase (trembl)


A0A068QK91_9VIRU Uncharacterized protein (trembl)


A0A068QK96_9VIRU Uncharacterized protein (trembl)


A0A068QKD0_9VIRU DNA ligase (NAD(+)) (trembl)


A0A068QKD1_9VIRU Putative tyrosine phosphatase (trembl)


A0A068QKD3_9VIRU Uncharacterized protein (trembl)


A0A068QKD4_9VIRU Uncharacterized protein (trembl)


A0A068QKD6_9VIRU DNA-directed RNA polymerase subunit (trembl)


A0A068QKD7_9VIRU Lipid membrane protein (trembl)


A0A068QKE1_9VIRU Patatin phospholipase (trembl)


A0A068QKE7_9VIRU Uncharacterized protein (trembl)


A0A068QKF6_9VIRU dUTP diphosphatase (trembl)


A0A068QKF8_9VIRU Uncharacterized protein (trembl)


A0A068QKF9_9VIRU Uncharacterized protein (trembl)


A0A068QKG9_9VIRU Hydrolase, NUDIX family (trembl)