B0LBX4_9VIRU Putative nuclear shuttle protein (trembl)


cytoplasm

biolink:CellularComponent biolink:AnatomicalEntity biolink:OrganismalEntity biolink:BiologicalEntity biolink:NamedThing biolink:PhysicalEssence biolink:SubjectOfInvestigation biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.


host cell cytoplasm

The cytoplasm of a host cell.


host cell nucleus

A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.


viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.


B0LBX6_9VIRU Putative movement protein (trembl)


membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.


B0LBX8_9VIRU Putative replicase protein (trembl)


RNA binding

biolink:MolecularActivity biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

Binding to an RNA molecule or a portion thereof.


RNA helicase activity

Unwinding of an RNA helix, driven by ATP hydrolysis.


catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.


nucleotidyltransferase activity

Catalysis of the transfer of a nucleotidyl group to a reactant.


endodeoxyribonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.


DNA replication

biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:Occurrent biolink:OntologyClass biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.


metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.


K4JUL8_ABHV DNA-directed DNA polymerase (trembl)


nucleotide binding

Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.


nucleic acid binding

Binding to a nucleic acid.


DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).


DNA-directed DNA polymerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.


3'-5'-DNA exonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.


base-excision repair, gap-filling

Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template.


nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.


SOS response

An error-prone process for repairing damaged microbial DNA.


viral DNA genome replication

The replication of a viral DNA genome.


DNA replication proofreading

Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.


K4JUM2_ABHV Putative tRNA ligase (trembl)


ligase activity

Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.


K4JUM7_ABHV Uncharacterized protein (trembl)


DNA ligase activity

Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.


DNA ligase (ATP) activity

Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).


ATP binding

Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.


DNA ligation

The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.


DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.


DNA recombination

Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.


DNA damage response

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.


DNA biosynthetic process

The biosynthetic process resulting in the formation of DNA.


K4JV09_ABHV Putative inhibitor of apoptosis protein (trembl)


cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.


ubiquitin protein ligase activity

Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.


positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.


regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.


K4JV15_ABHV Uncharacterized protein (trembl)


K4JV20_ABHV Uncharacterized protein (trembl)


K4JV33_ABHV ribonucleoside-diphosphate reductase (trembl)


ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.


metal ion binding

Binding to a metal ion.


The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.


K4JV47_ABHV Putative DEAD-box ATP-dependent RNA helicase (trembl)


helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.


hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.


K4JV51_ABHV Uncharacterized protein (trembl)


K4JV75_ABHV Uncharacterized protein (trembl)


K4JV80_ABHV Putative inhibitor of apoptosis protein (trembl)


K4JVA2_ABHV Eukaryotic translation initiation factor 3 30 kDa subunit (trembl)


K4JX26_ABHV Uncharacterized protein (trembl)


K4JX31_ABHV Uncharacterized protein (trembl)


K4JX33_ABHV Putative DNA packaging terminase (trembl)


chromosome organization

A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.


K4JX37_ABHV Uncharacterized protein (trembl)


K4JX93_ABHV PHTF1/2 N-terminal domain-containing protein (trembl)


K4JYD8_ABHV Putative eukaryotic translation initiation factor (trembl)


translation initiation factor activity

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.


GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.


formation of translation preinitiation complex

The joining of the small ribosomal subunit, ternary complex, and mRNA.


formation of cytoplasmic translation initiation complex

Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.


translation

The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.


translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


K4JYE9_ABHV Uncharacterized protein (trembl)


actin filament polymerization

Assembly of actin filaments by the addition of actin monomers to a filament.


actin filament

A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.


K4JYG0_ABHV Putative DNA replication origin-binding helicase (trembl)


DNA replication origin binding

Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.


K4JYG8_ABHV Uncharacterized protein (trembl)


K4JYH2_ABHV Uncharacterized protein (trembl)


K4JYI3_ABHV Uncharacterized protein (trembl)


K4JYK0_ABHV Putative methyltransferase (trembl)


methyltransferase activity

Catalysis of the transfer of a methyl group to an acceptor molecule.


methylation

The process in which a methyl group is covalently attached to a molecule.


K4JYM5_ABHV Putative guanylate kinase (trembl)


guanylate kinase activity

Catalysis of the reaction: ATP + GMP = ADP + GDP.


kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


transferase activity

Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.


phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.


K4K8F3_ABHV Uncharacterized protein (trembl)


K4K8G2_ABHV Ribonucleoside-diphosphate reductase (trembl)


An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.


K4K8H0_ABHV Uncharacterized protein (trembl)


K4K8L0_ABHV Uncharacterized protein (trembl)


K4K8L9_ABHV Putative chloride channel (trembl)


chloride channel activity

Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.


K4K8M7_ABHV Uncharacterized protein (trembl)


A0A223FUM6_9VIRU Capsid protein (trembl)


structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex.


RNA-dependent RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.


mRNA methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.


RNA-templated transcription

The synthesis of an RNA transcript from an RNA template.


DNA-templated transcription

The synthesis of an RNA transcript from a DNA template.


RNA processing

Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.


viral RNA genome replication

The replication of a viral RNA genome.


mRNA methylation

The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.


mitigation of host antiviral defense response

A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction.


viral entry into host cell

The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.


viral penetration into host nucleus

The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid.


T=1 icosahedral viral capsid

The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres.


host cell

A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.


virion component

Any constituent part of a virion, a complete fully infectious extracellular virus particle.


REN_ABMVW Replication enhancer protein (sprot)


viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.


TRAP_ABMVW Transcriptional activator protein (sprot)


NSP_ABMVW Nuclear shuttle protein (sprot)


single-stranded DNA binding

Binding to single-stranded DNA.


transport of virus in host, cell to cell

The transport of a virus between adjacent cells in a multicellular organism.


DNA transport

The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


host cell plasma membrane

The plasma membrane surrounding a host cell.


host cell membrane

Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.


host intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.


host cell endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).


host cell endoplasmic reticulum membrane

The lipid bilayer surrounding the host cell endoplasmic reticulum.


REP_ABMVW Replication-associated protein (sprot)


nuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids.


endonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.


A0A7S7YEA6_9VIRU Pectinesterase inhibitor domain-containing protein (trembl)


A0A7S7YEA8_9VIRU Rho termination factor N-terminal domain-containing protein (trembl)


DNA-templated transcription termination

The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.


A0A7S7YEA9_9VIRU Putative HD hydrolase (trembl)


A0A7S7YEB4_9VIRU Transmembrane protein (trembl)


A0A7S7YEC7_9VIRU Ser/Thr protein kinase (trembl)


protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.


protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


signal transduction

biolink:Pathway biolink:BiologicalProcess biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:NamedThing biolink:OntologyClass biolink:Occurrent biolink:ThingWithTaxon biolink:PhysicalEssenceOrOccurrent

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.


cyclic nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.


A0A7S7YED2_9VIRU Uncharacterized protein (trembl)


A0A7S7YED5_9VIRU Putative glycosyltransferase (trembl)


protein heterodimerization activity

Binding to a nonidentical protein to form a heterodimer.


A0A7S7YEF6_9VIRU Uncharacterized protein (trembl)


A0A7S7YEH0_9VIRU Myristylated protein (trembl)


A0A7S7YEH3_9VIRU Uncharacterized protein (trembl)


A0A7S7YEH4_9VIRU Uncharacterized protein (trembl)


A0A7S7YEJ2_9VIRU Endonuclease/exonuclease/phosphatase domain-containing protein (trembl)


phospholipase activity

Catalysis of the hydrolysis of a glycerophospholipid.


Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.


sphingomyelin metabolic process

The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.


A0A7S7YEL7_9VIRU G2/mitotic-specific cyclin (trembl)


cyclin-dependent protein serine/threonine kinase regulator activity

Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.


A0A7S7YEL9_9VIRU Putative late transcription factor VLTF-3 (trembl)


regulation of viral transcription

Any process that modulates the frequency, rate or extent of the transcription of the viral genome.


A0A7S7YEN0_9VIRU Uncharacterized protein (trembl)


A0A7S7YEN8_9VIRU DOD-type homing endonuclease domain-containing protein (trembl)


A0A7S7YEN9_9VIRU Ureidoglycolate hydrolase (trembl)


A0A7S7YEP8_9VIRU Ser/Thr protein kinase (trembl)


A0A7S7YEQ2_9VIRU Uncharacterized protein (trembl)


A0A7S7YEQ7_9VIRU Ribonucleotide reductase large subunit (trembl)


A0A7S7YEQ8_9VIRU Class 3 lipase (trembl)


lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.


A0A7S7YES2_9VIRU Uncharacterized protein (trembl)


A0A7S7YES5_9VIRU BTB/POZ domain-containing protein (trembl)


protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.


A0A7S7YES6_9VIRU DNA-3-methyladenine glycosylase (trembl)


Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.


alkylated DNA binding

Binding to an alkylated residue in DNA.


Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site.


base-excision repair

In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.


base-excision repair, AP site formation

The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.


DNA dealkylation involved in DNA repair

The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).


response to stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.


A0A7S7YET0_9VIRU Protein kinase domain-containing protein (trembl)


A0A7S7YET6_9VIRU Putative myristoylated membrane protein (trembl)


A0A7S7YET9_9VIRU Ser/Thr protein kinase (trembl)


A0A7S7YEU1_9VIRU Uncharacterized protein (trembl)


A0A7S7YEU5_9VIRU Uncharacterized protein (trembl)


A0A7S7YEU9_9VIRU Rho termination factor N-terminal domain-containing protein (trembl)


A0A7S7YEV1_9VIRU PAN domain-containing protein (trembl)


A0A7S7YEV8_9VIRU Uncharacterized protein (trembl)


A0A7S7YEW0_9VIRU dCMP deaminase (trembl)


zinc ion binding

Binding to a zinc ion (Zn).


A0A7S7YEX3_9VIRU Putative GIY-YIG endonuclease (trembl)


crossover junction DNA endonuclease activity

Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).


5'-flap endonuclease activity

Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.


double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.


A0A7S7YEX7_9VIRU Protein phosphatase 2C (trembl)


protein serine/threonine phosphatase activity

Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.


negative regulation of stress-activated MAPK cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


positive regulation of canonical NF-kappaB signal transduction

Any process that activates or increases the frequency, rate or extent of a canonical  NF-kappaB signaling cascade.


negative regulation of canonical NF-kappaB signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


positive regulation of canonical Wnt signaling pathway

Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


A0A7S7YEY6_9VIRU Uncharacterized protein (trembl)


A0A7S7YEY7_9VIRU Ser/Thr protein kinase (trembl)


A0A7S7YEZ0_9VIRU MORN repeat-containing protein (trembl)


spermatid development

The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.


A0A7S7YEZ4_9VIRU Uncharacterized protein (trembl)


A0A7S7YEZ5_9VIRU Uncharacterized protein (trembl)


A0A7S7YEZ9_9VIRU Uncharacterized protein (trembl)


A0A7S7YF01_9VIRU Uncharacterized protein (trembl)


A0A7S7YF10_9VIRU Fibronectin type-III domain-containing protein (trembl)


A0A7S7YF17_9VIRU dihydrofolate reductase (trembl)


dihydrofolate reductase activity

Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.


NADP binding

Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.


glycine biosynthetic process

The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid.


dihydrofolate metabolic process

The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.


tetrahydrofolate biosynthetic process

The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.


folic acid metabolic process

The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


A0A7S7YF19_9VIRU Uncharacterized protein (trembl)


A0A7S7YF23_9VIRU Uncharacterized protein (trembl)


A0A7S7YF27_9VIRU Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (trembl)


translation elongation factor activity

Functions in chain elongation during polypeptide synthesis at the ribosome.


Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.


7-methylguanosine mRNA capping

Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.


translational elongation

The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.


A0A7S7YF86_9VIRU Uncharacterized protein (trembl)


A0A7S7YF87_9VIRU Uncharacterized protein (trembl)


A0A7S7YF91_9VIRU thymidylate synthase (trembl)


thymidylate synthase activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.


transferase activity, transferring one-carbon groups

Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).


dTMP biosynthetic process

The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).


nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).


A0A7S7YFA0_9VIRU Ribonucleoside-diphosphate reductase (trembl)


intein-mediated protein splicing

The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.


A0A7S7YFD0_9VIRU PAN domain-containing protein (trembl)


A0A7S7YFF8_9VIRU Proliferating cell nuclear antigen (trembl)


DNA polymerase processivity factor activity

An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.


leading strand elongation

The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork.


regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.


mismatch repair

A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.


translesion synthesis

The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.


A0A7S7YFG8_9VIRU Nudix hydrolase (trembl)


NADH pyrophosphatase activity

Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.


ADP-ribose diphosphatase activity

Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.


NAD binding

Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.


A0A7S7YFH2_9VIRU Uncharacterized protein (trembl)


A0A7S7YFL3_9VIRU Zinc finger PHD-type domain-containing protein (trembl)


A0A7S7YFP4_9VIRU RDD domain-containing protein (trembl)


A0A7S7YFR6_9VIRU Zf-PARP domain-containing protein (trembl)


A0A7S7YFS7_9VIRU Linker histone H1 (trembl)


nucleosome assembly

The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.


nucleosome

A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.


A0A7S7YFT3_9VIRU Uncharacterized protein (trembl)


A0A7S7YFU2_9VIRU Uncharacterized protein (trembl)


A0A7S7YFU3_9VIRU BTB/POZ domain-containing protein (trembl)


ubiquitin protein ligase binding

Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.


regulation of proteolysis

Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


proteasome-mediated ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


A0A7S7YFX7_9VIRU Uncharacterized protein (trembl)


A0A7S7YG12_9VIRU Uncharacterized protein (trembl)


A0A7S7YG43_9VIRU Nucleoside diphosphate kinase (trembl)


A0A7S7YG46_9VIRU Uncharacterized protein (trembl)


A0A7S7YG54_9VIRU DNA polymerase (trembl)


A0A7S7YG56_9VIRU Zf-MYND domain-containing protain (trembl)


A0A7S7YG57_9VIRU Uncharacterized protein (trembl)


A0A7S8BCZ2_9VIRU DNA methyltransferase (trembl)


RNA methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.


site-specific DNA-methyltransferase (adenine-specific) activity

Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.


nucleic acid metabolic process

Any cellular metabolic process involving nucleic acids.


A0A7S8BD17_9VIRU Putative holliday junction resolvase (trembl)


A0A7S8BD30_9VIRU Putative tRNA-His guanylyltransferase (trembl)


A0A7S8BD64_9VIRU Replication factor C subunit 1 (trembl)


DNA clamp loader activity

Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.


ATP hydrolysis activity

Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.


DNA clamp unloader activity

Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis.


DNA replication factor C complex

A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.


A0A7S8BD73_9VIRU Aspartyl/asparaginy/proline hydroxylase domain-containing protein (trembl)


A0A7S8BD83_9VIRU PAN domain-containing protein (trembl)


A0A7S8BDC1_9VIRU Uncharacterized protein (trembl)


A0A7S8BDC4_9VIRU Rho termination factor N-terminal domain-containing protein (trembl)


A0A7S8BDD9_9VIRU Uncharacterized protein (trembl)


A0A7S8BDE8_9VIRU ribonuclease H (trembl)


RNA-DNA hybrid ribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.


RNA metabolic process

The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


DNA replication, removal of RNA primer

Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.


ribonuclease H2 complex

A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.


A0A7S8BDF4_9VIRU Fused protein of histone H3 and histone H4 (trembl)


structural constituent of chromatin

The action of a molecule that contributes to the structural integrity of chromatin.


A0A7S8BDG2_9VIRU ribonucleoside-diphosphate reductase (trembl)


A0A7S8BDH8_9VIRU Deoxyuridine triphosphatase (trembl)


magnesium ion binding

Binding to a magnesium (Mg) ion.


dUTP diphosphatase activity

Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate.


dUMP biosynthetic process

The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).


dUTP catabolic process

The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.


A0A7S8BDI8_9VIRU Uncharacterized protein (trembl)


A0A7S8BDJ0_9VIRU Uncharacterized protein (trembl)


A0A7S8BDK8_9VIRU Uncharacterized protein (trembl)


A0A7S8BDM0_9VIRU Ser/Thr protein kinase (trembl)


transposition

Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.


A0A7S8BDP7_9VIRU Uncharacterized protein (trembl)


A0A7S8BDQ3_9VIRU Exonuclease domain-containing protein (trembl)


exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.


A0A7S8BDS4_9VIRU Proliferating cell nuclear antigen (trembl)


A0A7S8BDT1_9VIRU Uncharacterized protein (trembl)


cysteine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.


A0A7S8BDU8_9VIRU Mitochondrial chaperone BCS1 (trembl)


A0A7S8BEF7_9VIRU DEDDy 3'-5' exonuclease (trembl)


3'-5' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.


nucleobase-containing compound metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.


thymidylate kinase activity

Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.


dUDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).


dTDP biosynthetic process

The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).


dTTP biosynthetic process

The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.


The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.


A0A7S8BEH3_9VIRU Ser/Thr protein kinase (trembl)


A0A7S8BEJ2_9VIRU Putative HNH endonuclease (trembl)


A0A7S8BEK3_9VIRU Polysaccharide lyase, partial (trembl)


lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.


carbohydrate binding

Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.


carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.


extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.


A0A7S8BEK6_9VIRU Cysteine-tRNA ligase (trembl)


A0A7S8BEK8_9VIRU DUF4178 domain-containing protein (trembl)


A0A7S8BEN5_9VIRU Uncharacterized protein (trembl)


A0A7S8BEP5_9VIRU Ribonuclease H (trembl)


A0A7S8BEP6_9VIRU High mobility group protein (trembl)


DNA binding, bending

The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


regulation of transcription by RNA polymerase II

Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.


ATP-dependent chromatin remodeler activity

An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.


chromatin remodeling

A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.


A0A7S8BEQ0_9VIRU Major capsid protein (trembl)


A0A7S8BEQ9_9VIRU Dual specificity phosphatase (trembl)


phosphoprotein phosphatase activity

Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.


protein tyrosine phosphatase activity

Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


protein tyrosine/serine/threonine phosphatase activity

Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


dephosphorylation

The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.


A0A7S8BER2_9VIRU Putative membrane protein (trembl)


A0A7S8BET7_9VIRU PIF1-like helicase (trembl)


DNA helicase activity

Unwinding of a DNA helix, driven by ATP hydrolysis.


catalytic activity, acting on DNA

Catalytic activity that acts to modify DNA.


telomere maintenance

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.


DNA duplex unwinding

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.


A0A7S8BEU8_9VIRU Transmembrane protein (trembl)


A0A7S8BEV4_9VIRU Uncharacterized protein (trembl)


A0A7S8BEW0_9VIRU Transcription elongation factor S-II (trembl)


YR665_MIMIV Uncharacterized protein R665 (sprot)


COLL7_MIMIV Collagen-like protein 7 (sprot)


extracellular matrix structural constituent conferring tensile strength

A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.


extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.


extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.


YL673_MIMIV Putative serine/threonine-protein kinase L673 (sprot)


protein serine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.


YL670_MIMIV Putative serine/threonine-protein kinase L670 (sprot)


YR679_MIMIV Putative serine/threonine-protein kinase R679 (sprot)


YL678_MIMIV Putative SET domain-containing protein L678 (sprot)


YL675_MIMIV Putative ankyrin repeat protein L675 (sprot)


regulation of barbed-end actin filament capping

Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.


UVE1H_MIMIV Putative UV-damage endonuclease (sprot)


nucleotide-excision repair

A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).


response to UV

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


YL682_MIMIV Uncharacterized protein L682 (sprot)


YR694_MIMIV Uncharacterized protein R694 (sprot)


MGMT_MIMIV Probable methylated-DNA--protein-cysteine methyltransferase (sprot)


Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.


YR692_MIMIV Uncharacterized protein R692 (sprot)


YR691_MIMIV Uncharacterized protein R691 (sprot)


YL688_MIMIV Uncharacterized protein L688 (sprot)


YL690_MIMIV Uncharacterized protein L690 (sprot)


UNAP_MIMIV Probable UDP-N-acetylglucosamine pyrophosphorylase (sprot)


Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.


The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.


YL701_MIMIV Uncharacterized protein L701 (sprot)


YR699_MIMIV Uncharacterized protein R699 (sprot)


Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.


YR695_MIMIV Uncharacterized protein R695 (sprot)


YR707_MIMIV Uncharacterized protein R707 (sprot)


glycosyltransferase activity

Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).


YR706_MIMIV Uncharacterized protein R706 (sprot)


YR705_MIMIV Uncharacterized protein R705 (sprot)


YL702_MIMIV Uncharacterized protein L702 (sprot)


YL720_MIMIV Endonuclease 8-like L720 (sprot)


damaged DNA binding

Binding to damaged DNA.


DNA-(apurinic or apyrimidinic site) endonuclease activity

Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).


hydrolase activity, hydrolyzing N-glycosyl compounds

Catalysis of the hydrolysis of any N-glycosyl bond.


DNA N-glycosylase activity

Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


YL716_MIMIV Putative glutamine amidotransferase-like protein L716 (sprot)


glutamine metabolic process

The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.


YL725_MIMIV Uncharacterized protein L725 (sprot)


YL724_MIMIV Uncharacterized protein L724 (sprot)


YR722_MIMIV Uncharacterized protein R722 (sprot)


metallopeptidase activity

Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


YR721_MIMIV Uncharacterized protein R721 (sprot)


CFXQ_MIMIV Putative cfxQ-like protein R730 (sprot)


YR727_MIMIV Uncharacterized protein R727 (sprot)


YL733_MIMIV Uncharacterized ABC transporter ATP-binding protein/permease L733 (sprot)


ATPase-coupled transmembrane transporter activity

Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.


YL742_MIMIV Putative BTB/POZ domain-containing protein L742 (sprot)


YR740_MIMIV Uncharacterized protein R740 (sprot)


mitochondrial fission

The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


Y749_MIMIV Putative homeobox protein R749 (sprot)


RNA polymerase II transcription regulatory region sequence-specific DNA binding

Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.


DNA-binding transcription factor activity

A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.


embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.


animal organ morphogenesis

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


anterior/posterior axis specification

The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


cell differentiation

The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


YR756_MIMIV Uncharacterized protein R756 (sprot)


iron-sulfur cluster binding

Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.


4 iron, 4 sulfur cluster binding

Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.


tRNA methylation

The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.


rRNA base methylation

The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.


YR753_MIMIV Putative F-box/LRR-repeat protein R753 (sprot)


YR848_MIMIV Putative ankyrin repeat protein R848 (sprot)


transcription cis-regulatory region binding

Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.


positive regulation of transcription by RNA polymerase II

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.


YR866_MIMIV Uncharacterized protein R866 (sprot)


YR260_MIMIV DnaJ-like protein R260 (sprot)


Hsp70 protein binding

Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.


heat shock protein binding

Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.


unfolded protein binding

Binding to an unfolded protein.


protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.


YR259_MIMIV Uncharacterized protein R259 (sprot)


tRNA guanylyltransferase activity

Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.


tRNA modification

The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.


tRNA 5'-end processing

The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA.


thymidine kinase activity

Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.


deoxyribonucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.


thymidine metabolic process

The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.


YR853_MIMIV Uncharacterized protein R853 (sprot)


YL851_MIMIV Uncharacterized protein L851 (sprot)


aminoacyl-tRNA ligase activity

Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.


cysteine-tRNA ligase activity

Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).


tRNA aminoacylation for protein translation

The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.


cysteinyl-tRNA aminoacylation

The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


YL872_MIMIV Uncharacterized protein L872 (sprot)


YR871_MIMIV Uncharacterized protein R871 (sprot)


mRNA binding

Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.


YR646_MIMIV Uncharacterized protein R646 (sprot)


RFCS3_MIMIV Putative replication factor C small subunit L499 (sprot)


DNA-templated DNA replication

A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.


Rad17 RFC-like complex

A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


Elg1 RFC-like complex

A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


YL585_MIMIV Uncharacterized protein L585 (sprot)


YR596_MIMIV Probable FAD-linked sulfhydryl oxidase R596 (sprot)


flavin-dependent sulfhydryl oxidase activity

Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins.


thiol oxidase activity

Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2.


flavin adenine dinucleotide binding

Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.


liver development

The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.


YR595_MIMIV Uncharacterized protein R595 (sprot)


lysophospholipase activity

Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.


acylglycerol lipase activity

Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.


phosphatidylserine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine.


monoacylglycerol catabolic process

The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.


P4H_MIMIV Putative prolyl 4-hydroxylase (sprot)


Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.


iron ion binding

Binding to an iron (Fe) ion.


oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.


L-ascorbic acid binding

Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.


dioxygenase activity

Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.


YR592_MIMIV Putative helicase R592 (sprot)


YL591_MIMIV Uncharacterized protein L591 (sprot)


YR600_MIMIV Putative ankyrin repeat protein R600 (sprot)


chloroplast targeting sequence binding

Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.


protein targeting to chloroplast

The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved.


positive regulation of JNK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.


negative regulation of canonical Wnt signaling pathway

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


YR598_MIMIV Putative ankyrin repeat protein R598 (sprot)


YL606_MIMIV Uncharacterized protein L606 (sprot)


PPIL_MIMIV Structural PPIase-like protein L605 (sprot)


peptidyl-prolyl cis-trans isomerase activity

Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).


plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.


Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.


YR614_MIMIV Putative band 7 family protein R614 (sprot)


YL612_MIMIV Uncharacterized protein L612 (sprot)


YR001_MIMIV Putative replication origin-binding protein (sprot)


YR008_MIMIV Uncharacterized putative helicase R8 (sprot)


YL020_MIMIV Uncharacterized protein L20 (sprot)


YL018_MIMIV Putative sel1-like repeat-containing protein L18 (sprot)


ERAD pathway

The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.


YL021_MIMIV Putative sel1-like repeat-containing protein L21 (sprot)


YL033_MIMIV Putative KilA-N domain-containing protein L33 (sprot)


YL032_MIMIV Putative KilA-N domain-containing protein L32 (sprot)


YR040_MIMIV Uncharacterized protein R40 (sprot)


YL048_MIMIV Uncharacterized protein L48 (sprot)


YL065_MIMIV Uncharacterized protein L65 (sprot)


COLL1_MIMIV Collagen-like protein 1 (sprot)


YL068_MIMIV Uncharacterized protein L68 (sprot)


YR080_MIMIV Putative resolvase R80 (sprot)


DNA strand exchange activity

Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.


regulation of DNA-templated transcription

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


DNA integration

The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.


YL079_MIMIV TnpB-like protein L79 (sprot)


YL088_MIMIV Putative ankyrin repeat protein L88 (sprot)


protein localization to T-tubule

A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


regulation of cardiac muscle contraction

Any process that modulates the frequency, rate or extent of cardiac muscle contraction.


T-tubule

Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.


YL086_MIMIV Putative ankyrin repeat protein L86 (sprot)


YL091_MIMIV Putative ankyrin repeat protein L91 (sprot)


YR104_MIMIV Putative transposase R104 (sprot)


YL103_MIMIV Putative resolvase L103 (sprot)


YL115_MIMIV Putative helicase L115 (sprot)


replication fork processing

The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.


YR119_MIMIV Uncharacterized protein R119 (sprot)


tyrosine-tRNA ligase activity

Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+.


identical protein binding

Binding to an identical protein or proteins.


protein homodimerization activity

Binding to an identical protein to form a homodimer.


tyrosine binding

Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid.


tyrosyl-tRNA aminoacylation

The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


YR132_MIMIV Uncharacterized protein R132 (sprot)


chondroitin sulfate biosynthetic process

The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


YL128_MIMIV Putative GMC-type oxidoreductase L128 (sprot)


choline dehydrogenase activity

Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde.


oxidoreductase activity, acting on CH-OH group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


glycine betaine biosynthetic process from choline

The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline.


YL136_MIMIV Uncharacterized protein L136 (sprot)


Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose.


pyridoxal phosphate binding

Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.


polysaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


YR135_MIMIV Putative GMC-type oxidoreductase R135 (sprot)


YR154_MIMIV Putative BTB/POZ domain and WD-repeat protein R154 (sprot)


maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


90S preribosome

A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


small-subunit processome

A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


YL153_MIMIV Uncharacterized protein L153 (sprot)


YR151_MIMIV Uncharacterized acetyltransferase R151 (sprot)


arylamine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


acetyltransferase activity

Catalysis of the transfer of an acetyl group to an acceptor molecule.


acyltransferase activity

Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).


YR160_MIMIV Uncharacterized protein R160 (sprot)


YL759_MIMIV Uncharacterized protein L759 (sprot)


YR758_MIMIV Uncharacterized protein R758 (sprot)


5'-nucleotidase activity

Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.


pyrimidine deoxyribonucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


deoxyribonucleotide catabolic process

The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


YR757_MIMIV Putative F-box protein R757 (sprot)


YR771_MIMIV Putative resolvase R771 (sprot)


YL770_MIMIV TnpB-like protein L770 (sprot)


YL778_MIMIV Uncharacterized protein L778 (sprot)


YR776_MIMIV Uncharacterized protein R776 (sprot)


YL783_MIMIV Putative BTB/POZ domain and WD-repeat protein R783 (sprot)


microtubule binding

Binding to a microtubule, a filament composed of tubulin monomers.


YL780_MIMIV Uncharacterized protein L780 (sprot)


Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH.


methionine adenosyltransferase regulator activity

Binds to and modulates the activity of methionine adenosyltransferase.


The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.


dTDP-rhamnose biosynthetic process

The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate.


extracellular polysaccharide biosynthetic process

The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.


methionine adenosyltransferase complex

A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules.


COLL5_MIMIV Collagen-like protein 5 (sprot)


COLL4_MIMIV Collagen-like protein 4 (sprot)


ATP-dependent peptidase activity

Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.


serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.


serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


protein targeting to peroxisome

The process of directing proteins towards the peroxisome, usually using signals contained within the protein.


protein processing

Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.


protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


peroxisomal matrix

The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.


TF2B_MIMIV Putative transcription initiation factor IIB-like protein (sprot)


RNA polymerase II core promoter sequence-specific DNA binding

Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.


RNA polymerase II general transcription initiation factor activity

A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.


TBP-class protein binding

Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).


transcriptional start site selection at RNA polymerase II promoter

Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.


DNA-templated transcription initiation

The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.


RNA polymerase II preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.


transcription preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription.


RNA polymerase II core complex assembly

The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex.


transcription preinitiation complex

A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.


UNG_MIMIV Probable uracil-DNA glycosylase (sprot)


uracil DNA N-glycosylase activity

Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.


base-excision repair, AP site formation via deaminated base removal

A base-excision repair, AP site formation process occurring via excision of a deaminated base.


YL248_MIMIV Uncharacterized protein L248 (sprot)


YL247_MIMIV Uncharacterized HNH endonuclease L247 (sprot)


hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.


YL245_MIMIV Uncharacterized HNH endonuclease L245 (sprot)


HSP7L_MIMIV Heat shock protein 70 homolog (sprot)


ATP-dependent protein folding chaperone

Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.


endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.


YR253_MIMIV Uncharacterized protein R253 (sprot)


YR252_MIMIV Uncharacterized protein R252 (sprot)


DNA protection

Any process in which DNA is protected from damage by, for example, oxidative stress.


YL268_MIMIV Putative serine/threonine-protein kinase L268 (sprot)


YR266_MIMIV Putative J domain-containing protein R266 (sprot)


protein refolding

The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


chaperone cofactor-dependent protein refolding

The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.


YL264_MIMIV Uncharacterized WD repeat-containing protein L264 (sprot)


YL274_MIMIV Uncharacterized protein L274 (sprot)


YL271_MIMIV Putative ankyrin repeat protein L271 (sprot)


YL280_MIMIV Uncharacterized acetyltransferase L280 (sprot)


YL279_MIMIV Putative ankyrin repeat protein L279 (sprot)


YR277_MIMIV Uncharacterized protein R277 (sprot)


MCAR_MIMIV Mitochondrial carrier-like protein L276 (sprot)


host cell mitochondrion

A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.


host cell mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae.


YL275_MIMIV Putative BTB/POZ domain-containing protein L275 (sprot)


YR287_MIMIV Uncharacterized protein R287 (sprot)


YL282_MIMIV Uncharacterized protein L282 (sprot)


UBPL2_MIMIV Putative ubiquitin carboxyl-terminal hydrolase L293 (sprot)


cysteine-type deubiquitinase activity

An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.


cysteine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


YR290_MIMIV Putative ATP-dependent RNA helicase R290 (sprot)


four-way junction helicase activity

Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.


3'-5' DNA helicase activity

Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.


DNA unwinding involved in DNA replication

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.


G-quadruplex DNA unwinding

The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.


chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.


YL288_MIMIV Putative B-type lectin protein L288 (sprot)


COLL3_MIMIV Collagen-like protein 3 (sprot)


RPO5_MIMIV DNA-directed RNA polymerase subunit 5 (sprot)


RNA polymerase I activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase II activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


RNA polymerase III activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


DNA-directed 5'-3' RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


5'-3' RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.


DNA-directed RNA polymerase complex

A protein complex that possesses DNA-directed RNA polymerase activity.


YL233_MIMIV Putative zinc protease L233 (sprot)


metalloendopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


YL294_MIMIV Uncharacterized protein L294 (sprot)


RNH_MIMIV Probable ribonuclease H (sprot)


END4_MIMIV Putative endonuclease 4 (sprot)


phosphoric diester hydrolase activity

Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.


deoxyribonuclease IV (phage-T4-induced) activity

Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.


YL300_MIMIV Uncharacterized protein L300 (sprot)


YR305_MIMIV Uncharacterized protein R305 (sprot)


DNA ligase (NAD+) activity

Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).


YR302_MIMIV Uncharacterized protein R302 (sprot)


YR301_MIMIV Putative serine/threonine-protein kinase R301 (sprot)


YR311_MIMIV Putative RING finger protein R311 (sprot)


YL310_MIMIV Uncharacterized protein L310 (sprot)


YL309_MIMIV Uncharacterized protein L309 (sprot)


YR307_MIMIV PP2C-like domain-containing protein R307 (sprot)


GNA1_MIMIV Probable glucosamine 6-phosphate N-acetyltransferase (sprot)


glucosamine 6-phosphate N-acetyltransferase activity

Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.


acyltransferase activity, transferring groups other than amino-acyl groups

Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).


monosaccharide binding

Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


FPG_MIMIV Probable formamidopyrimidine-DNA glycosylase (sprot)


oxidized purine nucleobase lesion DNA N-glycosylase activity

Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.


hydrolase activity, acting on glycosyl bonds

Catalysis of the hydrolysis of any glycosyl bond.


8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.


class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.


YL193_MIMIV Uncharacterized glycosyltransferase L193 (sprot)


COLL2_MIMIV Collagen-like protein 2 (sprot)


GLRX_MIMIV Probable glutaredoxin (sprot)


YR197_MIMIV Uncharacterized protein R197 (sprot)


YL208_MIMIV Uncharacterized protein L208 (sprot)


YL207_MIMIV Putative helicase L207/L206 (sprot)


hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.


YL205_MIMIV Putative serine/threonine-protein kinase L205 (sprot)


spliceosomal complex assembly

The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.


regulation of mRNA processing

Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.


RABL_MIMIV Probable Rab-related GTPase (sprot)


GTPase activity

Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.


GTP binding

Binding to GTP, guanosine triphosphate.


protein transport

The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of exocytosis

Any process that modulates the frequency, rate or extent of exocytosis.


YR213_MIMIV Uncharacterized protein R213 (sprot)


YL211_MIMIV Uncharacterized protein L211 (sprot)


RPO6_MIMIV DNA-directed RNA polymerase subunit 6 (sprot)


tRNA transcription by RNA polymerase III

The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.


YL813_MIMIV Uncharacterized protein L813 (sprot)


YR811_MIMIV Putative ariadne-like RING finger protein R811 (sprot)


YL798_MIMIV Uncharacterized protein L798 (sprot)


UBC4_MIMIV Probable bifunctional E2/E3 enzyme R795 (sprot)


ubiquitin-protein transferase activity

Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.


ubiquitin conjugating enzyme activity

Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.


protein ubiquitination

The process in which one or more ubiquitin groups are added to a protein.


YR390_MIMIV Uncharacterized protein R390 (sprot)


YL389_MIMIV Uncharacterized protein L389 (sprot)


YL396_MIMIV Putative ATP-dependent RNA helicase L396 (sprot)


transcription initiation at RNA polymerase II promoter

A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.


embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


RFCS1_MIMIV Putative replication factor C small subunit R395 (sprot)


YL394_MIMIV Putative HD domain-containing protein L394 (sprot)


dGTPase activity

Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate.


dGTP catabolic process

The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.


regulation of innate immune response

Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.


HSP70_MIMIV Heat shock 70 kDa protein homolog (sprot)


COLL6_MIMIV Collagen-like protein 6 (sprot)


YR708_MIMIV Uncharacterized phosphoglycerate mutase family protein R708 (sprot)


YL712_MIMIV Uncharacterized protein L712 (sprot)


YR710_MIMIV Uncharacterized protein R710 (sprot)


UBC2_MIMIV Probable ubiquitin-conjugating enzyme E2 L709 (sprot)


YR664_MIMIV Putative ankyrin repeat protein R664 (sprot)


protein kinase regulator activity

Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.


regulation of intracellular signal transduction

Any process that modulates the frequency, rate or extent of intracellular signal transduction.


arginine-tRNA ligase activity

Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).


arginyl-tRNA aminoacylation

The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


YR655_MIMIV Putative glycosyltransferase R655 (sprot)


YR654_MIMIV Putative fucosyltransferase R654 (sprot)


fucosyltransferase activity

Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage.


protein glycosylation

A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


fucosylation

The covalent attachment of a fucosyl group to an acceptor molecule.


YR653_MIMIV Uncharacterized protein R653 (sprot)


DNMK_MIMIV Putative deoxynucleotide monophosphate kinase (sprot)


Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate.


YL511_MIMIV Uncharacterized protein L511 (sprot)


Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.


RNA methylation

Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.


cap1 mRNA methylation

Methylation of the ribose of the first nucleotide of a 5'-capped mRNA.


cap2 mRNA methylation

Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA.


RFCS4_MIMIV Putative replication factor C small subunit L510 (sprot)


YL509_MIMIV Uncharacterized protein L509 (sprot)


YR519_MIMIV Putative zinc metalloproteinase R519 (sprot)


YR517_MIMIV Putative serine/threonine-protein kinase R517/R518 (sprot)


regulation of autophagy

Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


positive regulation of autophagy

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.


response to starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.


negative regulation of collateral sprouting

Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting.


autophagosome

A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.


phagophore assembly site membrane

A cellular membrane associated with the phagophore assembly site.


YL516_MIMIV Uncharacterized protein L516 (sprot)


YL515_MIMIV Uncharacterized protein L515 (sprot)


YR513_MIMIV Uncharacterized protein R513 (sprot)


YR526_MIMIV Putative alpha/beta hydrolase R526 (sprot)


triglyceride lipase activity

Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.


RHBDL_MIMIV Putative rhomboid protein L523 (sprot)


UBC3_MIMIV Probable ubiquitin-conjugating enzyme E2 R521 (sprot)


YL520_MIMIV Putative BTB/POZ domain-containing protein L520 (sprot)


regulation of G protein-coupled receptor signaling pathway

Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.