name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino) tetrahydro-imidazo[1,2-a]pyridin-2-yl)-heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-7-(1-methyl-1H-imidazol-4-yl)-4-methyl-2-(methylamino) heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyridazin-3-yl)-heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyrimidin-2-yl)-heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(2-methylpyrazol-3-yl)-heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(oxazolin-2-yl)-heptanoic acid]1 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(1-methylpyrazol-3-yl) heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-7-(1-methyl-1H-imidazol-2-yl)-4-methyl-2-(methylamino) heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(1-methylpyrazol-4-yl)-heptanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-8-(pyridin-2-yl)-octanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyridine-2-yl)-heptanoic acid]1 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyridin-4-yl)-heptanoic acid]1 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyridin-3-yl)-heptanoic acid]1 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyrimidin-2-yl)-heptanoic acid]1 cyclosporin A


name: [2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyrid-4-yl) heptanoic acid]1[(R)-methoxymethyl Sar]3 cyclosporin A


name: [2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyrid-2-yl)heptanoic acid]1[(R)-hydroxymethyl Sar]3 cyclosporin A


name: [2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-7-(pyrid-2-yl)heptanoic acid]1[(R)-thiomethyl Sar]3 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-6-(pyrimidin-2-yloxy)-hexanoic acid]1 cyclosporin A


name: [(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-6-(pyridin-4-ylmethoxy)-hexanoic acid]1 cyclosporin A


name: PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F, mitochondrial (sprot)

description: A peptidyl-prolyl cis-trans isomerase F, mitochondrial that is encoded in the genome of human.


name: 4-[3-(5-Chloro-2-ethanesulfonyl-benzyl)-2, 4-dioxo-6-trifluoromethoxy-1,2,3,4-tetrahydro-quinazolin-8-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester


osimertinib

A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.


ROCAGLAMIDE

An organic heterotricyclic compound that is 2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan substituted by hydroxy groups at positions 1 and 8b, methoxy groups at positions 6 and 8, a 4-methoxyphenyl group at position 3a, a phenyl group at position 3 and a N,N-dimethylcarbamoyl group at position 1. Isolated from Aglaia odorata and Aglaia duperreana, it exhibits antineoplastic activity.


name: LITAF_HUMAN Lipopolysaccharide-induced tumor necrosis factor-alpha factor (sprot)

description: A lipopolysaccharide-induced tumor necrosis factor-alpha factor that is encoded in the genome of human.


name: ANPRC_MOUSE Atrial natriuretic peptide receptor 3 (sprot)

description: An atrial natriuretic peptide receptor 3 that is encoded in the genome of mouse.


name: CCG8_HUMAN Voltage-dependent calcium channel gamma-8 subunit (sprot)

description: A voltage-dependent calcium channel gamma-8 subunit that is encoded in the genome of human.


name: (1R,3r,5S,6s)-3-[8-amino-1-(4-{[4-(trifluoromethyl) pyridin-2-yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin-3-yl]bicyclo[3.1.0] hexane-6-carboxylic acid


lesinurad

A member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout.


name: BAD_HUMAN Bcl2-associated agonist of cell death (sprot)

description: A Bcl2-associated agonist of cell death that is encoded in the genome of human.


H31_HUMAN Histone H3.1 (sprot)

A histone H3 that is a translation product of any of the following genes in human: HIST1H3A/HIST1H3B/HIST1H3C/HIST1H3D/HIST1H3E/HIST1H3F/HIST1H3G/HIST1H3H/HIST1H3I/HIST1H3J.


ARGI1_HUMAN Arginase-1 (sprot)

An arginase-1 that is encoded in the genome of human.


name: ARGI2_HUMAN Arginase-2, mitochondrial (sprot)

description: An arginase-2, mitochondrial that is encoded in the genome of human.


name: CCG2_HUMAN Voltage-dependent calcium channel gamma-2 subunit (sprot)

description: A voltage-dependent calcium channel gamma-2 subunit that is encoded in the genome of human.


name: US10106508, Example 14 5-((5-(2-Methoxyethoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-yl)amino)-2-methylbenzonitrile (I-14)


name: US10106508, Example 17 N-(4-Chloro-3-nitrophenyl)-5-(1-ethoxyethoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-amine (I-17)


name: US10106508, Example 22 N-(4-Chloro-3-fluorophenyl)-5-(tetrahydro-2H-pyran-4-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]-quinazolin-10-amine (I-22)


name: US10106508, Example 23 N-(4-Chloro-3-fluorophenyl)-5-(tetrahydrofuran-3-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-amine (I-23)


name: US10106508, Example 27 N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-isopropoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-amine (I-27)


name: SMYD3_HUMAN Histone-lysine N-methyltransferase SMYD3 (sprot)

description: A histone-lysine N-methyltransferase SMYD3 that is encoded in the genome of human.


ECKOL

A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.


DIECKOL

A phlorotannin isolated from a brown alga Ecklonia cava which exhibits antioxidant, hepatoprotective and anticoagulant activities.


name: MGAT1_HUMAN Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (sprot)

description: An alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


name: 1-(2-{2-[3-methyl-2-(trifluoromethyl) imidazo[1, 2-b]pyridazin-6-yl]ethynyl}-1-phenyl-1H-imidazol-4-yl) pyrrolidin-2-one


name: UNG_VACCW Uracil-DNA glycosylase (sprot)


ruxolitinib

A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.


baricitinib

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis.


name: PI4KB_HUMAN Phosphatidylinositol 4-kinase beta (sprot)

description: A phosphatidylinositol 4-kinase beta that is encoded in the genome of human.


name: 5-(pyrimidin-4-ylamino)isoindolin-1-one (Cpd. No. 3F)


name: (2R,4R)-4-amino-5-(3'-chlorobiphenyl-4-yl)-2-hydroxy-pentanoic acid benzyl ester


S10A9_HUMAN Protein S100-A9 (sprot)

A protein S100-A9 that is encoded in the genome of human.


name: UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 (sprot)

description: A ubiquitin-like modifier-activating enzyme 6 that is encoded in the genome of human.


name: (2R,4R)-2-Amino-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic Acid Ethyl Ester


name: (2R,4R)-2-Amino-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic Acid Hexyl Ester


name: (3S)-3-(4-((3-(2-(Trifluoromethyl)phenyl)benzo [b]thiophen-5-yl)methoxy)phenyl) hex-4-ynoic acid


name: 2-((1r,3r)-3-Hydroxy-1-(4-((3-(2-methylphenyl) benzo[b]thiophen-5-yl)methoxy)phenyl)cyclobutyl) acetic acid


name: {1-[1-(2-Fluorophenyl)-1H-pyrazol-4-yl]propyl}-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, enantiomer 1 and 2


desmopressin

A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.


name: {(S)-6-[(R)-7-Fluoro-4-(4-hydroxy-phenoxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester


name: {(S)-6-[(R)-7-Fluoro-4-(4-imidazol-1-yl-phenoxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester


name: {(S)-6-[(R)-4-(4-Ethylcarbamoyl-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester


name: {(S)-6-[(R)-4-(4-bromo-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester


name: PA24A_HUMAN Cytosolic phospholipase A2 (sprot)

description: A cytosolic phospholipase A2 that is encoded in the genome of human.


name: RORB_HUMAN Nuclear receptor ROR-beta (sprot)

description: A nuclear receptor ROR-beta that is encoded in the genome of human.


name: PEX14_HUMAN Peroxisomal membrane protein PEX14 (sprot)

description: A peroxisomal membrane protein PEX14 that is encoded in the genome of human.


name: PD1L1_HUMAN Programmed cell death 1 ligand 1 (sprot)

description: A programmed cell death 1 ligand 1 that is encoded in the genome of human.


miltefosine

A phospholipid that is the hexadecyl monoester of phosphocholine.


name: NF2L2_HUMAN Nuclear factor erythroid 2-related factor 2 (sprot)

description: A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of human.


name: KEAP1_HUMAN Kelch-like ECH-associated protein 1 (sprot)

description: A kelch-like ECH-associated protein 1 that is encoded in the genome of human.


name: PO5F1_HUMAN POU domain, class 5, transcription factor 1 (sprot)

description: A POU domain, class 5, transcription factor 1 that is encoded in the genome of human.


name: Preparation of methyl 2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-oxoisoindoline-5-carboxylate


name: Preparation of 2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-oxoisoindoline-5-carboxylic acid


name: GAS6_HUMAN Growth arrest-specific protein 6 (sprot)

description: A growth arrest-specific protein 6 that is encoded in the genome of human.


dezocine

(7S,8S)-7-Amino-8-methyl-5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogen at position 8 and one of the hydrogens at position 6 are substituted by each end of a tetramethylene bridge. A synthetic opioid analgesic, it has mixed opiod agonist and antagonist properties. Although it is used for pain management, it can produce opioid withdrawal syndrome in patients already dependent on other opioids, and its clinical application is limited by side effects such as dizziness.


name: 5-(((trans)-4-(dimethylamino) cyclohexyl) (ethyl) amino)-N-((3-methoxy-1, 5-dimethyl-1H-pyrazol-4-yl) methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide


name: BRD9_HUMAN Bromodomain-containing protein 9 (sprot)

description: A bromodomain-containing protein 9 that is encoded in the genome of human.


name: CECR2_HUMAN Chromatin remodeling regulator CECR2 (sprot)

description: A chromatin remodeling regulator CECR2 that is encoded in the genome of human.


name: TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (sprot)

description: A transcription initiation factor TFIID subunit 1 that is encoded in the genome of human.


hydroxyurea

A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.


name: RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit (sprot)

description: A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of human.


TRIAPINE

Triapine is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro.


name: example 3A.02, on page 196 of WO15017610


name: KAT2B_HUMAN Histone acetyltransferase KAT2B (sprot)

description: A histone acetyltransferase KAT2B that is encoded in the genome of human.


A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin.


name: T23O_HUMAN Tryptophan 2,3-dioxygenase (sprot)

description: A tryptophan 2,3-dioxygenase that is encoded in the genome of human.


name: (2R,4S)-4-[(1-benzyl-1H-tetrazole-5-carbonyl)-amino]-5-biphenyl-4-yl-2-methyl-pentanoic acid benzyl ester


name: SGMR2_MOUSE Sigma intracellular receptor 2 (sprot)

description: A sigma intracellular receptor 2 that is encoded in the genome of mouse.


name: ERR2_HUMAN Steroid hormone receptor ERR2 (sprot)

description: A steroid hormone receptor ERR2 that is encoded in the genome of human.


name: 3-Chloro-5-cyano-pyridine-2-carboxylic acid [3-((3R,4aS)-1-amino-3-methyl-4a-oxo-3,4,6,7,8,9-hexahydro-4a inverted question mark6-thia-2,5,9a-triaza-benzocyclohepten-3-yl)-4-fluoro-phenyl]-amide


name: 5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((3R,4aS)-1-amino-3-methyl-4a-oxo-3,4,6,7,8,9-hexahydro-4a inverted question mark6-thia-2,5,9a-triaza-benzocyclohepten-3-yl)-4-fluoro-phenyl]-amide


name: 5-Fluoro-3-methyl-pyridine-2-carboxylic acid [3-((3R,4aS)-1-amino-3-methyl-4a-oxo-3,4,6,7,8,9-hexahydro-4a inverted question mark6-thia-2,5,9a-triaza-benzocyclohepten-3-yl)-4-fluoro-phenyl]-amide


name: SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 (sprot)

description: A sphingosine-1-phosphate lyase 1 that is encoded in the genome of human.


name: P2C16_ARATH Protein phosphatase 2C 16 (sprot)

description: A protein that is a translation product of the HAB1 gene in Arabidopsis thaliana.


A member of the class of quinazolines that is quinazoline which is substituted by a pyridin-3-yl group and a (1-benzylpiperidin-4-yl)nitrilo group at positions 2 and 4, respectively.


dofetilide

A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an  anti-arrhythmia drug.


name: {4-[({[5-(3,5-Dimethylisoxazol-4-yl)-1H-indazol-3-yl]carbonyl}amino)methyl] piperidin-1-yl}acetic acid hydrate


name: {4-[({[5-(3-fluorophenyl)-1H-indazol-3-yl]carbonyl}amino)methyl]piperidin-1-yl} acetic acid hydrate


name: {4-[({[5-(propan-2-yl)-1H-indazol-3-yl] carbonyl}amino)methyl]piperidin-1-yl} acetic acid


name: [4-({[(5-cyclohexyl-1H-indazol-3-yl) carbonyl]amino}methyl)piperidin-1-yl] acetic acid


ORTERONEL

A member of the class of pyrroloimidazoles that is 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole substituted by hydroxy and 6-(methylcarbamoyl)naphthalen-2-yl groups at position 7 (the 7S-stereoisomer). It is a non-steroidal 17,20-lyase inhibitor that suppresses androgen synthesis. It was previously in clinical development for the treatment of castration-resistant prostate cancer -- trial now discontinued.


name: CP21A_HUMAN Steroid 21-hydroxylase (sprot)

description: A steroid 21-hydroxylase that is encoded in the genome of human.


chlorothiazide

4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.


name: benzyl N-[3-[3-[[(E)-4-(dimethylamino) but-2-enoyl]amino] phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: propan-2-yl N-[3-[3-[3-methoxypropanoyl (methyl) amino]phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: benzyl N-[3-[3-[2-(trifluoromethyl) prop-2-enoylamino] phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: (2-chlorophenyl) methyl N-[3-[3-(2-oxopropanoylamino) phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: (2-chlorophenyl) methyl N-[3-[3-(2-oxobutanoylamino) phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: (3-fluorophenyl) methyl N-[3-[3-(2-oxobutanoylamino) phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: (3-fluorophenyl) methyl N-[3-[3-(2-oxopropanoylamino) phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: (3-fluorophenyl) methyl N-[3-[3-[2-(trifluoromethyl) prop-2-enoylamino] phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: (3-cyanophenyl) methyl N-[3-[3-(2-oxobutanoylamino) phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: (3-cyanophenyl) methyl N-[3-[3-(2-oxopropanoylamino) phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: benzyl N-[3-[2-[[(E)-4-(dimethylamino) but-2-enoyl]amino] phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]carbamate


name: Propane-1-sulfonic acid [3-(4-ethoxy-7H-pyrrolo[2,3-d] pyrimidine-5-carbonyl)-2,4-difluoro-phenyl]-amide


name: 2-Phenyl-6-((2-(pyrrolidin-1-yl)ethoxy)methyl) imidazo[2,1-b] thiazole maleate


name: {6-[(2R)-2-(Methoxymethyl)pyrrolidin-1-yl]pyridin-3-yl}[(3R)-3-methyl-1,4'-bipiperidin-1'-yl]methanone formic acid salt


angiotensin II

An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).


NOX4_HUMAN NADPH oxidase 4 (sprot)

An NADPH oxidase 4 that is encoded in the genome of human.


name: The synthesis of 2-amino-N-(5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-yl)acetamide


buparlisib

An aminopyridine that is 4-(trifluoromethyl)pyridin-2-amine substituted at position 5 by a 2,6-di(morpholin-4-yl)pyrimidin-4-y group. A selective PI3K inhibitor with anti-tumour properties.


name: UBE2F_HUMAN NEDD8-conjugating enzyme UBE2F (sprot)

description: A NEDD8-conjugating enzyme UBE2F that is encoded in the genome of human.


name: SGMR2_HUMAN Sigma intracellular receptor 2 (sprot)

description: A sigma intracellular receptor 2 that is encoded in the genome of human.


praliciguat

A member of the class of pyrazoles that is 5-fluoro-2-(1H-pyrazol-3-yl)pyrimidine which is substituted by a 2-fluorobenzyl group at position 1, 1,2-oxazol-3-yl group at position 5, and by a [3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]nitrilo group at position 4. It is a soluble guanylate cyclase stimulator under clinical development for the treatment of heart failure with preserved ejection fraction.


name: 1-Ethyl-4-[({(1R,2R and 1S,2S)-2-[4-(1H-pyrazol-5-yl)benzoyl] cyclohexyl}carbonyl)amino]-1H-pyrazole-3-carboxamide


name: (1R,2R and 1S,2S)-N-(5-Cyano-1-methyl-1H-pyrazol-4-yl)-2-[4-(3-methyl-1H-pyrazol-5-yl)benzoyl] cyclohexanecarboxamide


ATX2_HUMAN Ataxin-2 (sprot)

An ataxin-2 that is encoded in the genome of human.


name: CDC37_HUMAN Hsp90 co-chaperone Cdc37 (sprot)

description: An Hsp90 co-chaperone Cdc37 that is encoded in the genome of human.


name: RPE65_HUMAN Retinoid isomerohydrolase (sprot)

description: A retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of human.


name: RPE65_BOVIN Retinoid isomerohydrolase (sprot)


name: Synthesis of (E)-4-methyl-6-[2-[[methyl-(4-phenylbenzoyl)amino]methyl]phenoxy] hex-4-enoic acid


name: Synthesis of (E)-4-methyl-6-(2-((N-methyl-4-(5-methylfuran-2-yl)benzamido) methyl)phenoxy)hex-4-enoic acid


name: Synthesis of (E)-6-(2-((N,2-dimethylbenzofuran-5-carboxamido)methyl) phenoxy)-4-methylhex-4-enoic acid


name: Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-3-methylhex-2-enoic acid


name: Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-2-methylhex-2-enoic acid


name: Synthesis of 6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-2-methylhexanoic acid


name: Synthesis of 3-(3-((2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy) methyl)phenyl)propanoic acid


name: Synthesis of 2-(3-((2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy) methyl) phenyl)acetic acid


name: Synthesis of 2-(3-((2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy) methyl) phenoxy)acetic acid


name: Synthesis of 6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-2,2-dimethylhexanoic acid


name: Synthesis of 2-(3-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl) phenoxy)propyl) cyclopropane-1-carboxylic acid


name: Synthesis of 2-((3-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy) propyl)thio)acetic acid


name: Synthesis of 6-(2-((N,2-dimethylbenzofuran-5-carboxamido)methyl)phenoxy)-2,2-dimethylhexanoic acid


name: Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)-4-(trifluoromethyl) phenoxy)-4-methylhex-4-enoic acid


name: Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)hex-2-enoic acid


name: RHG35_HUMAN Rho GTPase-activating protein 35 (sprot)

description: A Rho GTPase-activating protein 35 that is encoded in the genome of human.


hydrocortisone butyrate

Cortisol esterified with butyric acid at the 17-hydroxy group.


cortisol

A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.


aldosterone

A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


A benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines.


name: AAAT_HUMAN Neutral amino acid transporter B(0) (sprot)

description: A neutral amino acid transporter B(0) that is encoded in the genome of human.


name: GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial (sprot)

description: A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of human.


vigabatrin

A gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase


name: ENV_HV1S1 Envelope glycoprotein gp160 (sprot)


CAPSD_HBVCJ Capsid protein (sprot)

A hepadnavirus-type capsid protein that is encoded in the genome of Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-).


name: UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.


name: 5-Chloro-7-{5-[1-(tetrahydro pyran-4-yl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-2,3-dihydro benzofuran-4-yl amine


name: 4-[5-(5-Amino-6-chloro-chroman-8-yl)-[1,3,4]oxadiazol-2-yl]-[1,4']bipiperidinyl-1'-carboxylic acid ethyl ester


name: 4-(5-chloropyridin-3-yl)-6-[(1R or S)-1-fluoro-1-(3-fluoropyridin-2-yl)ethyl]-5-[(trans-4-methylcyclohexyl)methyl]-5H-pyrrolo[3,2-d]pyrimidine-2-carboxylic acid (Enantiomer 1)


name: cis-4-(1H-benzoimidazole-5-carbonyl)-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline-10-carboxylic acid methyl ester


name: Trifluoromethanesulfonic acid cis-1-(1-trifluoromethanesulfonyl-1H-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridin-6-yl ester and Trifluoro-methanesulfonic acid cis-1-(3-trifluoromethanesulfonyl-3H-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridin-6-yl ester


name: CACB3_HUMAN Voltage-dependent L-type calcium channel subunit beta-3 (sprot)

description: A voltage-dependent L-type calcium channel subunit beta-3 that is encoded in the genome of human.


name: 5-(4-(4-methoxyphenoxy) piperidine-1-carbonyl)-N-((cis)-4-(4-(trifluoromethyl) phenoxy)cyclohexyl) picolinamide


name: 5-(4-(4-methoxybenzoyl) piperidine-1-carbonyl)-N-((cis)-4-(4-(trifluoromethyl) phenoxy)cyclohexyl) picolinamide


name: 5-(4-(4-cyanophenoxy) piperidine-1-carbonyl)-N-((cis)-4-(4-(trifluoromethyl) phenoxy)cyclohexyl) picolinamide


name: Tert-butyl 4-(6-(4-(4-cyanophenoxy) piperidine-1-carbonyl)nicotinamido) piperidine-1-carboxylate


name: 1,1,1-trifluoro-2-mehtylpropan-2-yl ((R or S)-2-((S or R)-1-acetamidoethyl)-4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)carbamate


name: 1,1,1-trifluoro-2-methylpropan-2-yl ((S or R)-2-((S or R)-1-acetamidoethyl)-4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)carbamte


name: 1,1,1-trifluoro-2-methylpropan-2-yl ((R or S)-2-((R or S)-1-acetamidoethyl)-4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)carbamate


name: US9663510, Example comparitive example 2


name: US9663510, Example comparitive example disclosed in WO 2011/063908 A1


name: US9663510, Example comparitive example 4


A semicarbazide derivative that is semicarbazide in which the amino group at position 2 is replaced by a [1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]amino group and the amino group adjacent to the carbonyl is replaced by a (2,6-dichloropyridin-4-yl)amino group. It is a potent S1P2 antagonist (IC50 = 17.6 nM).


name: 4-(2-methyl-4-(((1S,2S)-2-(quinolin-2-yl)cyclopropyl)methoxy) pyrimidin-5-yl)benzoic acid (enantiomer A)


name: 2-((1S,2S)-2-((2-methyl-5-p-tolylpyrimidin-4-yloxy)methyl)cyclopropyl) quinoline (enantiomer A)


name: 2-((1S,2S)-2-((2-methyl-5-(pyridin-4-yl)pyrimidin-4-yloxy) methyl)cyclopropyl) quinoline (enantiomer A)


name: 2-((1S,2S)-2-((5-(4-methoxyphenyl)-2-methylpyrimidin-4-yloxy)methyl)cyclopropyl) quinoline (enantiomer A)


name: 2-((1S,2S)-2-((5-(4-ethylphenyl)-2-methylpyrimidin-4-yloxy)methyl)cyclopropyl) quinoline (enantiomer A)


name: 4-(2-methyl-4-(((1S,2S)-2-(quinolin-2-yl)cyclopropyl)methoxy) pyrimidin-5-yl)benzonitrile (enantiomer A)


name: 1-(4-(2-methyl-4-(((1S,2S)-2-(quinolin-2-yl)cyclopropyl)methoxy) pyrimidin-5-yl)phenyl)ethanol (enantiomer A)


name: 2-((1S,2S)-2-((2-methyl-5-m-tolylpyrimidin-4-yloxy)methyl)cyclopropyl) quinoline (enantiomer A)


name: (4-(2-methyl-4-(((1S,2S)-2-(quinolin-2-yl)cyclopropyl)methoxy) pyrimidin-5-yl)phenyl)methanol (enantiomer A)


name: 5-(3-ethoxyphenyl)-2-methyl-6-(((1S,2S)-2-(quinolin-2-yl)cyclopropyl)methoxy) pyrimidin-1-ium 2,2,2-trifluoroacetate (enantiomer A)


name: 2-((1S,2S)-2-((2-methyl-5,5''''-bipyrimidin-4-yloxy)methyl)cyclopropyl) quinoline (enantiomer A)


name: 4-(((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methoxy)-2-methyl-5-(6-(methylsulfinyl)pyridin-3-yl)pyrimidine (R or S)


name: 2-((1S,2S)-2-((2-methyl-5-(1H-pyrazolo[3,4-b]pyridin-5-yl)pyrimidin-4-yloxy)methyl)cyclopropyl) quinoline (enantiomer A)


name: 1-(1-methyl-4-(2-methyl-4-(((1S,2S)-2-(pyridin-2-yl)cyclopropyl)methoxy) pyrimidin-5-yl)-1H-pyrazol-3-yl)ethanol(R or S)


name: 5-(4,4-Difluoro-cyclohexyl)-2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl) cyclopropyl) methoxy) pyrimidine


name: (trans)-4-Fluoro-4-(2-methyl-4-(((1S,2S)-2-(5-methyl-pyridin-2-yl) cyclopropyl) methoxy) pyrimidin-5-yl) cyclohexanol


name: (trans) 2-(4-4-(((1S,2S)-2-5-methoxypyridin-2-yl)cyclopropyl) methoxy)-2-methylpyrimidin-5-yl)cyclohexyl) propan-2-ol


name: (3R,4R and 3S,4S)-1-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3-hydroxypiperidine-4-carboxylic acid (7A)


name: UB2E1_HUMAN Ubiquitin-conjugating enzyme E2 E1 (sprot)

description: A ubiquitin-conjugating enzyme E2 E1 that is encoded in the genome of human.


name: S22A2_HUMAN Solute carrier family 22 member 2 (sprot)

description: A solute carrier family 22 member 2 that is encoded in the genome of human.


bictegravir

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid with the amino group of 2,4,6-trifluorobenzylamine. It is a second-generation integrase strand transfer inhibitor (INSTI) and used (as its sodium salt) for the treatment of HIV-1.


name: SGMR2_RAT Sigma intracellular receptor 2 (sprot)

description: A sigma intracellular receptor 2 that is encoded in the genome of rat.


name: EYA3_HUMAN Eyes absent homolog 3 (sprot)

description: An eyes absent homolog 3 that is encoded in the genome of human.


name: methyl 4-{N-[(5-{4-[4-({[(2-fluoro-5-methylphenyl)amino] carbonyl}amino)phenoxy] pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]-S-methylsulfonimidoyl} butanoate


name: 2-(4-Fluoro-3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl) phenyl]carbonyl} piperidin-3-yl] oxy}phenyl) propan-2-ol


name: 6-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl) phenyl] carbonyl}piperidin-3-yl] oxy}-2,3-dihydro-1H-inden-1-ol


name: (1R)-4-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl) phenyl] carbonyl} piperidin-3-yl]oxy}-2,3-dihydro-1H-inden-1-ol


name: (1S)-4-{[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-yl) phenyl] carbonyl} piperidin-3-yl] oxy}-2,3-dihydro-1H-inden-1-ol


name: CP17A_BOVIN Steroid 17-alpha-hydroxylase/17,20 lyase (sprot)


name: CP11A_BOVIN Cholesterol side-chain cleavage enzyme, mitochondrial (sprot)

description: A cytochrome P450 11A1, mitochondrial that is encoded in the genome of cow.


pioglitazone

A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.


DIPYRIDYL

A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.


name: Synthesis of (E) N (4 (4 (3 fluorobenzyloxy)3-chlorophenylamino)-7-(2-ethoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide


name: GP183_HUMAN G-protein coupled receptor 183 (sprot)

description: A G-protein coupled receptor 183 that is encoded in the genome of human.


name: GP142_HUMAN Probable G-protein coupled receptor 142 (sprot)

description: A probable G-protein coupled receptor 142 that is encoded in the genome of human.


POLG_GBVB Genome polyprotein (sprot)

A protein that is a translation product of the HGvBgp1 gene in GB virus-B.


name: Example 384 Preparation of 1-(3-(7-ethoxy-6-methoxy-quinazolin-4-yloxy)phenyl)-3-(1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)urea


name: Example 388 Preparation of 1-(5-(1,3-difluoro-2-methylpropan-2-yl) isoxazol-3-yl)-3-(3-(7-ethoxy-6-methoxy-quinazolin-4-ylthio)phenyl) urea


name: [(3S,4R) and (3R,4S)]-benzyl 3-ethyl-4-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate


name: (4S and 4R)-tert-butyl 4-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]oxy}-3,3-difluoropyrrolidine-1-carboxylate


name: 9-ethyl-6-({(3S)-1-[([(1R,2S) or (1R,2R) or (1S,2R) or (1S,2S)]-methylcyclobutyl)carbonyl] pyrrolidin-3-yl}oxy)-8-(2-methylpyrimidin-5-yl)-9H-purine


name: 4-(2-Hydroxy-2-methyl-pentanoylamino)-pyridine-2-carboxylic acid methyl ester


name: 2-{[3-(5-Aminopyrazin-2-yl)-6-cyclobutyl-2-fluorophenoxy]methyl}pyridine-3-carbonitrile trifluoroacetic acid salt


name: 5-{4-Cyclobutyl-2-fluoro-3-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}pyrazin-2-amine trifluoroacetic acid salt


name: NR2C1_RAT Nuclear receptor subfamily 2 group C member 1 (sprot)

description: A nuclear receptor subfamily 2 group C member 1 that is encoded in the genome of rat.


beta-catenin - TCF interaction inhibitor


name: RORG_MOUSE Nuclear receptor ROR-gamma (sprot)

description: A nuclear receptor ROR-gamma that is encoded in the genome of mouse.


name: 4-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(trifluoromethyl) phenyl]carbonyl} piperidin-3-yl] oxy}pyridine


name: 2-(3-{[(2R,5R)-2-methyl-5-{[4-(2,2,2-trifluoroethoxy) pyridin-2-yl]oxy} piperidin-1-yl] carbonyl}thiophen 2-yl)pyrimidine


name: 5-[4-(6, 7-Dihydro-5H-pyrrolo[2, 3-d]pyrimidin-4-yloxy)phenyl]-4,6-dimethylpyridazin-3(2H)-one (11)


name: 6-[4-(2,3-Dihydrofuro[3,2-c]pyridin-4-yloxy)phenyl]-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, trifluoroacetate salt (13)


name: 2-[6-(2-Aminopyrimidin-5-yl)-5-fluoropyridin-3-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]penzenesulfonamide as the hydrochloride salt


name: 3-(trans-2-((cyclo-propylmethyl)amino) cyclopropyl)-N-(4-(2,3-dihydroimidazo [2,1-b] [1,3]thiazol-6-yl)phenyl)benzamide bis(trifluoroacetate)


name: RLBP1_HUMAN Retinaldehyde-binding protein 1 (sprot)

description: A retinaldehyde-binding protein 1 that is encoded in the genome of human.


name: CEGT_HUMAN Ceramide glucosyltransferase (sprot)

description: A ceramide glucosyltransferase that is encoded in the genome of human.


acalabrutinib

A member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.


ATX1_HUMAN Ataxin-1 (sprot)

An ataxin-1 that is encoded in the genome of human.


name: TPH1_HUMAN Tryptophan 5-hydroxylase 1 (sprot)

description: A tryptophan 5-hydroxylase 1 that is encoded in the genome of human.


name: LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (sprot)

description: A large neutral amino acids transporter small subunit 1 that is encoded in the genome of human.


name: LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (sprot)

description: A large neutral amino acids transporter small subunit 2 that is encoded in the genome of human.


name: NOS1_MOUSE Nitric oxide synthase 1 (sprot)

description: A nitric oxide synthase 1 that is encoded in the genome of mouse.


name: (1S,2S or 1R,2R or 1S,2R or 1R,2S)-2-((S)-4-tosyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cylcopropanecarboxylic acid


name: (1S,2S or 1R,2R or 1S,2R or 1R,2S)-2-((S)-4-tosyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid


name: (1R,2S or 1R,2R or 1S,2S or 1S,2R)-2-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cylcopropanecarboxylic acid


name: (1R,2S or 1R,2R or 1S,2S or 1S,2R)-2-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid


name: (1R,2S or 1R,2R or 1S,2S or 1S,2R)-2-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid


name: (1R,2S or 1R,2R or 1S,2S or 1S,2R)-2-((S)-4-((3-chloro-1-ehtyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid


name: 3-{(2S)-4-[(4-fluoro-3-methoxyphenyl)sulfonyl]-6-[({[(1S or 1R)-1,2,2-trimethylpropyl]oxy}carbonyl) amino]-3,4-dihydro-2H-1,4-benzoxazin-2-yl}propanoic acid


name: 3-{(2S)-4-[(4-fluoro-3-methoxyphenyl)sulfonyl]-6-[({[(1S or 1R)-1,2,2-trimethylpropyl]oxy}cxarbonyl) amino]-3,4-dihydro-2H-1,4-benzoxazin-2-yl}propanoic acid


name: 4-[({5-[5-Chloro-2-(difluoromethoxy) phenyl]-1-oxidopyridin-2-yl}acetyl)amino] benzoic acid


name: 2-(1-((4-Carboxyphenyl)amino)-1-oxo-3-phenylpropan-2-yl)-5-(5-chloro-2-cyanophenyl)-4-methoxypyridine 1-oxide (Examples 23 and 24)


name: 2-(1-((4-carboxyphenyl)amino)-1-oxo-3-phenylpropan-2-yl)-5-(3-chloro-2,6-difluorophenyl)-4-methylpyridine 1-oxide (Example 25) and 6-(1-((4-carboxyphenyl)amino)-1-oxo-3-phenylpropan-2-yl)-3-(3-chloro-2,6-difluorophenyl)-2-methylpyridine 1-oxide (Example 26)


GLABRIDIN

A member of the class of  hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively.


name: MOT4_HUMAN Monocarboxylate transporter 4 (sprot)

description: A monocarboxylate transporter 4 that is encoded in the genome of human.


name: MCTS1_HUMAN Malignant T-cell-amplified sequence 1 (sprot)

description: A malignant T cell-amplified sequence 1 that is encoded in the genome of human.


name: PK3CA_RAT Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of rat.


name: PK3CB_RAT Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of rat.


WNT1_HUMAN Proto-oncogene Wnt-1 (sprot)

A proto-oncogene Wnt-1 that is encoded in the genome of human.


name: KCNJ5_HUMAN G protein-activated inward rectifier potassium channel 4 (sprot)

description: A G protein-activated inward rectifier potassium channel 4 that is encoded in the genome of human.


name: PGDH_RAT 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (sprot)

description: A 15-hydroxyprostaglandin dehydrogenase [NAD(+)] that is encoded in the genome of rat.


name: PGDH_MOUSE 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (sprot)

description: A 15-hydroxyprostaglandin dehydrogenase [NAD(+)] that is encoded in the genome of mouse.


name: Cyclopropanecarboxylic Acid [5-(6-benzyloxy-pyridin-3-yl)-[1,2,4]triazolo[1, 5-a]pyridin-2-yl]-amide


name: EIS_MYCTU N-acetyltransferase Eis (sprot)


elacestrant

A member of the class of tetralins that is 1,2,3,4-tetrahydronaphthalene which is substituted by hydroxy group at position 2 and by a 2-(ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl group at position 6R. It is a is an estrogen receptor degrader indicated for the treatment of postmenopausal women or adult men, with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy.


FSCN1_HUMAN Fascin (sprot)

A fascin that is encoded in the genome of human.


name: (+) (2S,3R)-3-[(4-bromophenyl) carbamoyl]spiro[bicyclo[2.2.1] heptane-7,1''-cyclopropane]-2-carboxylic acid


name: (+) tert-butyl {3-[(3R)-3-(4-cyanophenyl)-7-({[4-(methylsulfinyl)phenyl] carbamoyl}amino)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl] propyl}carbamate


name: ethyl hydrogen ({[(2S)-2-{[(4-bromophenyl)carbamoyl]amino}-4-methylpentanoyl]amino} methyl)phosphonate


name: ethyl hydrogen ({[(2S,3S)-2-{[(4-bromophenyl)carbamoyl]amino}-3-methylpentanoyl]amino} methyl)phosphonate


name: diethyl ({[(2S)-2-{[(4-bromophenyl)carbamoyl]amino} pentanoyl]amino}methyl) phosphonate


name: ethyl hydrogen ({[(2S)-2-{[(4-bromophenyl)carbamoyl]amino} pentanoyl]amino}methyl) phosphonate


name: dipropan-2-yl ({[(2S)-2-{[(4-bromophenyl)carbamoyl]amino} pentanoyl]amino}methyl) phosphonate


name: ethyl hydrogen ({[(2S)-2-{[(4-bromophenyl)carbamoyl]amino}-3-phenylpropanoyl]amino} methyl)phosphonate


name: Propan-2-yl hydrogen {[(2-{[(4-bromophenyl)carbamoyl]amino} pentanoyl)amino]methyl} phosphonate


name: {[(2S)-4-methyl-2-({[4-(methylsulfanyl)phenyl]carbamoyl} amino)pentanoyl]amino} acetic acid


name: diethyl ({[(2S)-4-methyl-2-({[4-(trifluoromethyl)phenyl]carbamoyl} amino)pentanoyl]amino} methyl)phosphonate


name: ethyl hydrogen ({[(2S)-4-methyl-2-({[4-(trifluoromethyl)phenyl]carbamoyl} amino)pentanoyl]amino} methyl)phosphonate


name: {[(2S)-4-methyl-2-({[4-(trifluoromethyl)phenyl]carbamoyl} amino)pentanoyl]amino} methanesulfonic acid


name: diethyl ({[(2S)-4-methyl-2-({[4-(methylsulfanyl)phenyl]carbamoyl} amino)pentanoyl]amino} methyl)phosphonate


name: 2-methyl-2-{[(2S)-4-methyl-2-({[4-(trifluoromethyl)phenyl]carbamoyl} amino)pentanoyl]amino} propanoic acid


name: PO2F2_HUMAN POU domain, class 2, transcription factor 2 (sprot)

description: A POU domain, class 2, transcription factor 2 that is encoded in the genome of human.


name: SAE2_HUMAN SUMO-activating enzyme subunit 2 (sprot)

description: A SUMO-activating enzyme subunit 2 that is encoded in the genome of human.


name: Preparation of 5-(2,4-di(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl methanol


name: Preparation of (3S,3'S)-4,4'-(7-phenyl pyrimido[4,5-d]pyrimidin-2,4-diyl)-di(3-methyl morpholine)


name: 2-(4-(2-Ethyl-3-((4-(4-fluorophenyl) thiazol-2-yl)(methyl)amino) imidazo[1,2-b]pyridazin-6-yl)-1-(methylsulfonyl) piperazin-2-yl) ethanol


name: 1-(2-Ethyl-3-((4-(4-fluorophenyl) thiazol-2-yl)(methyl)amino) imidazo[1,2-b]pyridazin-6-yl)piperidine-4-carboxylic acid


name: tert-butyl 5-(2-ethyl-3-((4-(4-fluorophenyl) thiazol-2-yl)(methyl)amino) imidazo[1,2-b]pyridazin-6-yl)hexahydro-pyrrolo[3,4-c] pyrrole-2(1H)-carboxylate


name: (9 S,14S)-14-[(E)-3-(5-Chloro-2-tetrazol-1-yl-phenyl)-acryloylamino]-5-methoxycarbonylamino-8,16,18-triaza-tricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaene-9-carboxylic acid ethyl ester, 2 TFA salt


name: {(9R,14S)-14-[(E)-3-(5-Chloro-2-tetrazol-1-yl-phenyl)-acryloylamino]-9-hydroxymethyl-8,16,18-triaza-tricyclo[13.2.1.02,7]octadeca-1(17),2,4,6,15(18)-pentaen-5-yl}-carbamic acid methyl ester, 2 TFA salt


name: [(R)-4-(3-chloro-benzenesulfonyl)-2-hydroxymethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-carbamic acid tert-butyl ester


name: (S)-tert-butyl (2-(2-((cyclobutylmethyl) amino)-2-oxoethyl)-4-((3-(trifluoromethyl) phenyl)sulfonyl)-3,4-dihydro-2H-benzo [b][1,4]oxazin-6-yl)carbamate


name: (S)-tert-butyl (2-(2-oxo-2-((3,3,3-trifluoropropyl)amino) ethyl)-4-((3-(trifluoromethyl)phenyl) sulfonyl)-3,4-dihydro-2H-benzo[b][1,4] oxazin-6-yl)carbamate


name: (S)-methyl 3-(2-(6-((tert-butoxycarbonyl) amino)-4-((3-(trifluoromethyl) phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)acetamido) propanoate


name: (5)-tert-butyl (2-(2-oxo-2-(thiazole-2-sulfonamido) ethyl)-4-((3-(trifluoromethyl) phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4] oxazin-6-yl)carbamate


name: (S)-tert-butyl (2-(2-oxo-2-(pyridine-2-sulfonamido) ethyl)-4-((3-(trifluoromethyl (phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4] oxazin-6-yl)carbamate


name: (S)-tert-butyl (2-(2-oxo-2-(pyridine-3-sulfonamido) ethyl)-4-((3-(trifluoromethyl) phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4] oxazin-6-yl)carbamate


name: (S)-tert-butyl (2-(2-oxo-2-((2-(trifluoromethyl)phenoxy) amino)ethyl)(trifluoromethyl) phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl) carbamate


name: (R or S)-neopentyl (5-((4-fluorophenyl)sulfonyl)-7-(hydroxymethyl)-5,6,7,8-tetrahydro-1,5-naphthyridin-3-yl)carbamate


name: (S or R)-neopentyl (5-((4-fluorophenyl)sulfonyl)-7-(hydroxymethyl)-5,6,7,8-tetrahydro-1,5-naphthyridin-3-yl)carbamate


name: 1,1,1-trifluoro-2-methylpropan-2-yl ((R or S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-2-((S or R)-2,2,2-trifluoro-1-hydroxyethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)carbamate


name: 1,1,1-trifluoro-2-methylpropan-2-yl ((S and R)-4-((4-fluorophenyl)sulfonyl)-2-((S and R)-2,2,2-trifluoro-1-hydroxyethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)carbamate


name: 4-{4-[3-(4-carbamoyl-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoyl}-piperazine-1-carboxylic acid tert-butyl ester


name: MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (sprot)

description: A mucosa-associated lymphoid tissue lymphoma translocation protein 1 that is encoded in the genome of human.


name: CNTA_ECOLI Carnitine monooxygenase oxygenase subunit (sprot)

description: A carnitine monooxygenase oxygenase subunit that is encoded in the genome of Escherichia coli K-12.


name: PER2_HUMAN Period circadian protein homolog 2 (sprot)

description: A period circadian protein homolog 2 that is encoded in the genome of human.


name: NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2 (sprot)

description: A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human.


name: TPH2_HUMAN Tryptophan 5-hydroxylase 2 (sprot)

description: A tryptophan 5-hydroxylase 2 that is encoded in the genome of human.


name: Step 1: Preparation of 5-bromo-6-chloro-3-((4-chlorophenyl)ethynyl)pyridin-2-yl acetate


name: Step 1: Preparation of 5-bromo-6-chloro-3-(p-tolylethynyl)pyridin-2-yl acetate


name: Step 1: Preparation of 6-chloro-N-methyl-2-(p-tolyl)-5-(3-((1-(trifluoromethyl)cyclopropyl)carbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxamide


amlexanox

A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.


P2Y13_HUMAN P2Y purinoceptor 13 (sprot)

A P2Y purinoceptor 13 that is encoded in the genome of human.


cangrelor

A nucleoside triphosphate analogue that is 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]adenosine carrying additional 2-(methylsulfanyl)ethyl and (3,3,3-trifluoropropyl)sulfanyl substituents at positions N6 and C2 respectively. Used (in the form of its tetrasodium salt) as an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries.


name: PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (sprot)

description: A receptor-type tyrosine-protein phosphatase beta that is encoded in the genome of human.


name: CAST1_HUMAN Cytosolic arginine sensor for mTORC1 subunit 1 (sprot)

description: A cytosolic arginine sensor for mTORC1 subunit 1 that is encoded in the genome of human.


name: GABR2_RAT Gamma-aminobutyric acid type B receptor subunit 2 (sprot)

description: A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of rat.


name: A. Preparation of 7-(2,6-difluoro-4-(2-methyl-2h-indazol-4-yl)benzyl)-6,7-dihydro-8H-pyrrolo[3,4-e][1,2,4]triazolo [4,3-a]pyridin-8-one


name: A. Preparation of 7-(2-fluoro-4-(2-methyl-2H-indazol-4-yl)benzyl)-6,7-dihydro-8H-pyrrolo [3,4-e][1,2,4]triazol[4,3-a]pyridin-8-one


name: A. Preparation of 7-(2-fluoro-4-(2-methyl-2H-indazol-5-yl)benzyl)-6,7-dihydro-8H-pyrrolo [3,4-e][1,2,4]triazolo[4,3-a]pyridin-8-one


name: N-{(1S)-1-[((3a(R and S), 6a(R and S)-1,1-dioxidohexahydro-5H-thieno[2,3-c]pyrrol-5-yl)carbonyl]propyl}-9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-amine


ivosidenib

A tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation.


name: 1-[4-(4, 6-Dimethylpyrimidin-5-yl)-3-methylphenoxy]pyrrolo[1, 2-a]pyrazine (4)


name: 4-[4-(4, 6-Dimethylpyrimidin-5-yl)phenoxy]pyrazolo[1, 5-a]pyrazine (7)


modafinil

A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.


KCY_HUMAN UMP-CMP kinase (sprot)

A UMP-CMP kinase that is encoded in the genome of human.


name: GLIS2_HUMAN Zinc finger protein GLIS2 (sprot)

description: A zinc finger protein GLIS2 that is encoded in the genome of human.


name: Preparation of tert-butyl 3-(2,6-dichloropyrimidin-4-yl)pyrrolidine-1-carboxylate


name: Synthesis of tert-butyl 3-(6-chloro-2-cyclopentylpyrimidin-4-yl)azetidine-1-carboxylate


name: Synthesis of (S)-2-amino-N-(phenylsulfonyl)pent-4-ynamide hydrochloride


name: Synthesis of (S)-2-amino-N-(methylsulfonyl)pent-4-ynamide hydrochloride


L-propargylglycine

A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens has been replaced by an ethynyl group. It causes the irreversible inactivation of gamma-cystathionase (also known as cystathionine gamma-lyase) and is used as an affinity labeling reagent for gamma-cystathionase and other enzymes.


An alanine derivative obtained by replacement of one of the methyl hydrogens in alanine with a cyano group


name: (2-(2-(Tert-butoxycarbonyl) guanidino)phenyl) boronic acid


fulvestrant

A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.


name: PAWR_HUMAN PRKC apoptosis WT1 regulator protein (sprot)

description: A PRKC apoptosis WT1 regulator protein that is encoded in the genome of human.


name: SCN8A_HUMAN Sodium channel protein type 8 subunit alpha (sprot)

description: A sodium channel protein type 8 subunit alpha that is encoded in the genome of human.


repotrectinib

An azamacrocycle with formula C18H18FN5O2. It is a tyrosine kinase inhibitor (highly potent against ROS1, TRKA-C, and ALK) used for the treatment of locally advanced or metastatic ROS1-positive non-small cell lung cancer.


A carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor).


name: GRK6_HUMAN G protein-coupled receptor kinase 6 (sprot)

description: A G protein-coupled receptor kinase 6 that is encoded in the genome of human.


name: 3-((5H-chromeno[3,4-c] pyridine-8-carboxamido) methyl)-5-tert-butylfuran-2-carboxylic acid


name: 4-((5H-chromeno[3,4-c] pyridine-8-carboxamido) methyl)-2,5-dimethylfuran-3-carboxylic acid


name: (R)-2-(2-chlorophenyl)-2-(5H-chromeno [3,4-c]pyridine-8-carboxamido) acetic acid


name: N-(3-(ethyl(methyl) carbamoyl) benzyl)-5H-chromeno [3,4-c]pyridine-8-carboxamide


name: N-(3-(cyclopropyl carbamoyl) benzyl)-5H-chromeno [3,4-c]pyridine-8-carboxamide


name: methyl 3-(3-((5H-chromeno[3,4-c]pyridine-8-carboxamido) methyl)phenyl) furan-2-carboxylate


name: N-(3-(2-methyl-imidazo[1,2-a] pyridin-3-yl) benzyl)-5H-chromeno[3,4-c] pyridine-8-carboxamide


name: N-(3-(imidazo [1,2-a] pyrimidin-3-yl)benzyl)-5H-chromeno[3,4-c] pyridine-8-carboxamide


name: ethyl 2-(3-((5H-chromeno[3,4-c] pyridine-8-carboxamido)methyl) phenyl)-5-(trifluoromethyl)-1H-imidazole-4-carboxylate


name: tert-butyl 3-(3-((5H-chromeno[3,4-c] pyridine-8-carboxamido) methyl)phenyl)-5,6-


name: ethyl 2-(3-((5H-chromeno[3,4-c] pyridine-8-carbox-amido)methyl)phenyl) oxazole-4-carboxylate


name: N-(3-(ethylcarbamoyl) benzyl)-6H-isochromeno [3,4-c] pyridine-8-carboxamide


name: methyl 3-((6H-isochromeno[4,3-d] pyrimidine-8-carboxamido) methyl)benzoate


name: 3-((6H-isochromeno [4,3-d] pyrimidine-8-carboxamido) methyl) benzoic acid


name: 2-[3-(morpholin-4-yl) propanamido]-N-[(1R)-1-phenylethyl]-6H-isochromeno [3,4-c] pyridine-8-carboxamide


name: (R)-N-(1-(3-methoxyphenyl) ethyl) benzofuro[2,3-c] pyridine-7-carboxamide


name: N-(2-hydroxy-1-phenylethyl) benzofuro [2,3-c]pyridine-7-carboxamide, TFA


name: N-(4-fluorobenzyl) benzofuro[2,3-c] pyridine-7-carboxamide, TFA


name: (R)-4-fluoro-N-(1-(3-methoxyphenyl) ethyl)benzofuro [2,3-c] pyridine-7-carboxamide


name: Preparation of 3-(4-amino-1-(piperidin-4-yl)-1H-pyrazolo [3, 4-d] pyrimidin-3-yl) ethynyl)-4-methyl-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) phenyl) benzamide


name: FAK2_MOUSE Protein-tyrosine kinase 2-beta (sprot)

description: A focal adhesion kinase 2 that is encoded in the genome of mouse.


name: Preparation of N-(3-((4-amino-1-isopropyl-1H-pyrazolo [3,4-d] pyrimidin-3-yl) ethynyl)-4-methylphenyl)-4-(4-methylpiperazin-1-yl) methyl) benzamide


name: ULK1_HUMAN Serine/threonine-protein kinase ULK1 (sprot)

description: A serine/threonine-protein kinase ULK1 that is encoded in the genome of human.


TOP1_ECOLI DNA topoisomerase 1 (sprot)

A type 1A DNA topoisomerase 1 that is encoded in the genome of Escherichia coli K-12.


name: Ethyl 9-cyano-5, 6-difluoro-3-oxo-3H-pyrido[3, 2, 1-kl]phenoxazine-2-carboxylate


name: 5, 6-Difluoro-9-nitro-3-oxo-3H-pyrido[3, 2,1-kl]phenoxazine-2-carboxylic acid


name: 9-Cyano-5, 6-d fluoro-3-oxo-3H-pyrido[3, 2, 1-d]phenoxazine-2-carboxylic acid


GYRB_ECOLI DNA gyrase subunit B (sprot)

A DNA gyrase subunit B that is encoded in the genome of Escherichia coli K-12.


name: 2.1. Methyl 2-[4-[3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-3-oxo-propyl]-2,5-dioxo-imidazolidin-4-yl]acetate (Cpd 182) and 2-[4-[3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-3-oxo-propyl]-2,5-dioxo-imidazolidin-4-yl]acetic acid


name: Ethanesulfonic acid [8-(1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(2-oxo-2,3-dihydro-1H-indol-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(3-methyl-3H-benzotriazol-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(3-methyl-1H-indazol-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(3-methyl-3H-benzoimidazol-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(3-fluoro-1-methyl-1H-indazol-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(3-methyl-1H-indazol-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Cyclopropanecarboxylic acid [8-(1-methyl-1H-indazol-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(1,5-dimethyl-1H-indazol-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer I


name: Ethanesulfonic acid [8-(1-methyl-1H-indazol-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(1-methyl-1H-indazol-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: 3-(4-Hydroxy-3,4-dihydro-1H-pyrano[4,3-c]pyridin-8-yl)-quinoline-8-carboxylic acid amide, Enantiomer I


name: Ethanesulfonic acid [8-(3-chloro-1H-indazol-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(4,4-difluoro-chroman-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(1-oxo-indan-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(2-oxo-2H-chromen-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(3-methyl-benzo[d]isoxazol-5-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer I


name: Ethanesulfonic acid [8-(5-fluoro-1-methyl-1H-indazol-6-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: Ethanesulfonic acid [8-(4,4-difluoro-isochroman-7-yl)-3,4-dihydro-1H-pyrano[4,3-c]pyridin-4-yl]-amide, Enantiomer II


name: SL9A3_RAT Sodium/hydrogen exchanger 3 (sprot)

description: A sodium/hydrogen exchanger 3 that is encoded in the genome of rat.


name: SL9A3_HUMAN Sodium/hydrogen exchanger 3 (sprot)

description: A sodium/hydrogen exchanger 3 that is encoded in the genome of human.


name: NPT2B_HUMAN Sodium-dependent phosphate transport protein 2B (sprot)

description: A sodium-dependent phosphate transport protein 2B that is encoded in the genome of human.


name: NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C (sprot)

description: A glutamate receptor ionotropic, NMDA 2C that is encoded in the genome of human.


name: NMDE4_HUMAN Glutamate receptor ionotropic, NMDA 2D (sprot)

description: A glutamate receptor ionotropic, NMDA 2D that is encoded in the genome of human.


name: 4-(4-((2-(5,6,7,8-tetrahydronaphthalen-2-yl)cyclohex-1-en-1-yl)methoxy) phenyl) butanoic Acid


name: 4-(4-((4''-(1-cyanocyclopropyl)-4-methyl-3,4,5,6-tetrahydro-[1,1''-biphenyl]-2-yl) methoxy) phenyl)butanoic Acid


name: NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)

description: A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.


name: 4-({cis or trans-4-[(3R or S)-3-(trifluoromethyl)piperidin-1-yl]cyclohexyl}amino) quinazoline-6-carbonitrile


name: 4-({trans-4-[(2R or 2S)-2-(hydroxymethyl)morpholin-4-yl]cyclohexyl}amino) quinazoline-6-carbonitrile


name: 4-({trans-4-[(2S,6S or 2R,6R)-2,6-dimethylmorpholin-4-yl]cyclohexyl}amino) quinazoline-6-carbonitrile


name: 4-({trans-4-[(2S or 2R)-2-methylmorpholin-4-yl]cyclohexyl}amino) quinazoline-6-carbonitrile


name: 4-({trans-4-[(4aS,7aS or 4aR,7aR)-hexahydrocyclopenta[b] [1,4]oxazin-4(4aH)-yl]cyclohexyl}amino) quinazoline-6-carbonitrile


name: 4-({trans-4-[(2R or 2S)-2-(trifluoromethyl)morpholin-4-yl]cyclohexyl}amino) quinazoline-6-carbonitrile


name: 4-{[(1S,2S,4S or 1R,2R,4R)-4-(4-fluoropiperidin-1-yl)-2-methylcyclohexyl]amino} quinazoline-6-carbonitrile


name: 4-{[(1S,2R,4S or 1R,2S,4R)-2-methyl-4-(morpholin-4-yl)cyclohexyl]amino} quinazoline-6-carbonitrile


name: AKTS1_HUMAN Proline-rich AKT1 substrate 1 (sprot)

description: A proline-rich AKT1 substrate 1 that is encoded in the genome of human.


name: NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (sprot)

description: A nuclear factor of activated T-cells, cytoplasmic 2 that is encoded in the genome of human.


name: 2-Amino-3-((3-chloro-4-fluorophenyl) amino)furo [2,3-c] pyridine-7-carbonitrile


name: 5-Chloro-N3-(3-chloro-4-fluorophenyl) benzo[b] thiophene-2,3-diamine hydrochloride


name: 5-Chloro-N3-(3-(trifluoro-methyl)phenyl) benzo[b] thiophene-2,3-diamine hydrochloride


name: 4-(2-Amino-3-((3-chloro-4-fluorophenyl) amino)furo [2,3-c]pyridin-7-yl) benzonitrile


name: Methyl 4-(2-amino-3-((3-chloro-4-fluorophenyl) amino)furo [2,3-c]pyridin-7-yl)benzoate


name: 4-(2-Amino-3-((3-chloro-4-fluorophenyl) amino)furo [2,3-c]pyridin-7-yl)-N-(2-methoxyethyl) benzamide


name: 4-(2-Amino-3-((3-chloro-4-fluorophenyl) amino)-5-methoxyfuro [2,3-c]pyridin-7-yl) benzonitrile


name: 7-Bromo-N3-(3-chloro-4-fluorophenyl) benzo[b] thiophene-2,3-diamine hydrochloride


name: N3-(benzo [d][1,3] dioxol-5-yl)benzo[b] thiophene-2,3-diamine


name: 7-(Benzo[d] [1,3]dioxol-5-yl)-N3-(3-chloro-4-fluorophenyl) furo[2,3-c] pyridine-2,3-diamine


name: I23O2_HUMAN Indoleamine 2,3-dioxygenase 2 (sprot)

description: An indoleamine 2,3-dioxygenase 2 that is encoded in the genome of human.


name: PSB8_HUMAN Proteasome subunit beta type-8 (sprot)

description: A proteasome subunit beta type-8 that is encoded in the genome of human.


name: 4-{4-[(trans-4-Morpholin-4-ylcyclohexyl)amino] quinazolin-6-yl} cyclohexanecarboxylic acid


name: 1-(3,3,5,5-tetramethylcyclohexyl)-N2-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole-2,5-diamine, salt with hydrochloric acid


name: AKA7G_MOUSE A-kinase anchor protein 7 isoform gamma (sprot)


name: RAMP1_HUMAN Receptor activity-modifying protein 1 (sprot)

description: A receptor activity-modifying protein 1 that is encoded in the genome of human.


name: BIRC7_HUMAN Baculoviral IAP repeat-containing protein 7 (sprot)

description: A baculoviral IAP repeat-containing protein 7 that is encoded in the genome of human.


name: ethyl N-[3-[[5-[(3,4-dimethyl-1H-pyrazole-5-carbonyl)amino] pyrimidin-2-yl]amino]phenyl] carbamate


name: MC4R_RAT Melanocortin receptor 4 (sprot)

description: A melanocortin receptor 4 that is encoded in the genome of rat.


name: DLTA_STRA5 D-alanine--D-alanyl carrier protein ligase (sprot)


name: RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (sprot)

description: A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human.


name: EYA3_MOUSE Eyes absent homolog 3 (sprot)

description: An eyes absent homolog 3 that is encoded in the genome of mouse.


name: CP26B_HUMAN Cytochrome P450 26B1 (sprot)

description: A cytochrome P450 26B1 that is encoded in the genome of human.


tamibarotene

A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.


Ro 40-6055

An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.


TTNPB

A  retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR).


BMS961 is a selective retinoic acid receptor gamma (RARgamma) agonist


TAZAROTENIC ACID

A thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene.


tazarotene

The ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of  psoriasis, acne, and sun-damaged skin.


name: CP46A_HUMAN Cholesterol 24-hydroxylase (sprot)

description: A cytochrome P450 46A1 that is encoded in the genome of human.


name: sulfamic acid [4-[4-(2,3-dihydro-1H-inden-1-ylamino)-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester


name: CCR9_HUMAN C-C chemokine receptor type 9 (sprot)

description: A C-C chemokine receptor type 9 that is encoded in the genome of human.


DIMETRIDAZOLE

A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl groups. An antiprotozoal drug, it has been banned by both the Government of Canada and the European Union as a livestock feed additive owing to  suspicions of it being carcinogenic.


name: GRM2_RAT Metabotropic glutamate receptor 2 (sprot)

description: A metabotropic glutamate receptor 2 that is encoded in the genome of rat.


name: FUCO_HUMAN Tissue alpha-L-fucosidase (sprot)

description: A tissue alpha-L-fucosidase that is encoded in the genome of human.


name: SMCA4_HUMAN Transcription activator BRG1 (sprot)

description: A transcription activator BRG1 that is encoded in the genome of human.


PB1_HUMAN Protein polybromo-1 (sprot)

A protein polybromo-1 that is encoded in the genome of human.


VNN1_HUMAN Pantetheinase (sprot)

A pantetheinase that is encoded in the genome of human.


name: PDCD1_HUMAN Programmed cell death protein 1 (sprot)

description: A programmed cell death protein 1 that is encoded in the genome of human.


name: TP4A3_HUMAN Protein tyrosine phosphatase type IVA 3 (sprot)

description: A protein tyrosine phosphatase type IVA 3 that is encoded in the genome of human.


name: HTRA1_HUMAN Serine protease HTRA1 (sprot)

description: A serine protease HTRA1 that is encoded in the genome of human.


name: 2-(5-methyl-2-{5-[(3-phenylpyridin-2-yl) carbonyl]hexahydropyrrolo[3,4-c] pyrrol-2(1H)-yl}-1,3-oxazol-4-yl) propan-2-ol


name: ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2 (sprot)

description: A neuronal acetylcholine receptor subunit beta-2 that is encoded in the genome of human.


name: 4-Chloro-1-(2-methoxy-ethyl)-1H-indole-3-carboxylic acid ((1S,3S)-1-hydroxy-3-methyl-cyclohexyl methyl)-amide


name: 4-Chloro-1-(2-methoxy-ethyl)-1H-indole-3-carboxylic acid (1-hydroxy-cyclohexyl methyl)-amide


name: Step 4: cis-4-Chloro-1-oxetan-3-yl-1H-indole-3-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexylmethyl)-amide


name: tert-butyl 2-((4-chloro-3-((4,4-difluorocyclohexyl) methyl carbamoyl)-1H-indol-1-yl)methyl)pyrrolidine-1-carboxylate


name: Preparations of 4-chloro-N-((4, 4-difluorocyclohexyl)methyl)-1-(2-azaspiro[3.3]heptan-6-yl)-1H-indole-3-carboxamide


name: GPBAR_MOUSE G-protein coupled bile acid receptor 1 (sprot)

description: A G-protein coupled bile acid receptor 1 that is encoded in the genome of mouse.


name: NTCP_HUMAN Hepatic sodium/bile acid cotransporter (sprot)

description: A hepatic sodium/bile acid cotransporter that is encoded in the genome of human.


name: Preparation of tert-butyl 1-ethynyl-3-azabicyclo[3.1.0]hexane-3-carboxylate


name: Procedure for Preparation of 1-ethynyl-3-azabicyclo[3.1.0]hexane


name: MMP17_HUMAN Matrix metalloproteinase-17 (sprot)

description: A matrix metalloproteinase-17 that is encoded in the genome of human.


STALP_HUMAN AMSH-like protease (sprot)

An AMSH-like protease that is encoded in the genome of human.


TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor.


name: (1 S,2 S,3 S,4R,5 S)-5-(4-chloro-3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol


name: (1 S,2 S,3 S,4R,5 S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-methylphenyl)-1-(hydroxymethyl)-6, 8-dioxabicyclo[3.2.1]octane-2,3,4-triol


name: 5-(4-(3-Phenoxycycloheptyl)phenyl)pentanoic acid (diastereomer 1)


name: UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 30 that is encoded in the genome of human.


name: 6-(((4-chlorophenyl) thio) methyl)-4-oxo-4H-pyran-3-yl 4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylate


name: 5-(((3,4-dichlorophenyl) thio) methyl)-2-oxo-1,2-dihydropyridin-3-yl 3-phenethyl-1H-pyrazole-5-carboxylate


name: 5-(((3,4-dichlorophenyl) thio) methyl)-2-oxo-1,2-dihydropyridin-3-yl 4-phenethyl-1H-pyrrole-2-carboxylate


name: 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-(hydroxymethyl) cyclopropyl)-4-(isopropylamino) nicotinamide


name: 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopropyl-amino)-N-((1r,4r)-4-(methylcarbamoyl) cyclohexyl) nicotinamide


name: Methyl 6-(6-(3-cyano-pyrrolo[1,2-b]pyridazin-7-yl)-4-(isopropylamino) nicotinamido) spiro[3.3]heptane-2-carboxylate


name: 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-(1-hydroxycyclobutyl) ethyl)-4-(isopropylamino) nicotinamide


name: N-(3-acetamidobicyclo [1.1.1]pentan-1-yl)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopropylamino) nicotinamide


name: 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(6-hydroxyspiro[3.3] heptan-2-yl)-4-(isopropylamino) nicotinamide


name: 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(6-hydroxy-6-methylspiro[3.3] heptan-2-yl)-4-(isopropylamino) nicotinamide


name: (R)-methyl (1-(4-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl) pyridin-4-yl)amino)phenyl) cyclopropyl)carbamate


name: Methyl ((1r,4r)-4-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(methylcarbamoyl) pyridin-4-yl)amino) cyclohexyl)carbamate


name: cyclobutyl ((1R,4r)-4-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl) pyridin-4-yl)amino) cyclohexyl)carbamate


name: isobutyl ((1R,4r)-4-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl) pyridin-4-yl)amino) cyclohexyl)carbamate


name: isopropyl ((1R,4r)-4-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl) pyridin-4-yl)amino) cyclohexyl)carbamate


name: ethyl ((1R,4r)-4-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl) pyridin-4-yl)amino) cyclohexyl)carbamate


name: methyl ((1R,4r)-4-(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(((1r,4R)-4-((methoxycarbonyl) amino)cyclohexyl)amino) nicotinamido)cyclohexyl) carbamate


name: N-(cyanomethyl)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2] octan-1-yl)amino) nicotinamide


name: N-(2-cyanoethyl)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2] octan-1-yl)amino) nicotinamide


name: methyl ((1S,4r)-4-(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(((1S,3R)-3-hydroxy-cyclohexyl)amino) nicotinamido) cyclohexyl)carbamate


name: (R)-4-((5-((3-acetoxy-2-fluoro-3-methylbutyl) carbamoyl)-2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)pyridin-4-yl)amino)bicyclo[2.2.2] octan-1-yl acetate


name: N-(cyanomethyl)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((4-(methylcarbamoyl) phenyl)amino) nicotinamide


name: N-(cyanomethyl)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((6-hydroxyspiro[3.3] heptan-2-yl)amino) nicotinamide


name: methyl ((1R,3r)-3-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl) pyridin-4-yl)amino) cyclobutyl)carbamate


name: 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2] octan-1-yl)amino)-N-(prop-2-yn-1-yl) nicotinamide


name: methyl (((1R,3r)-3-((2-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-(((1r,4R)-4-(cyclopropane carboxamido)cyclohexyl) carbamoyl)pyridin-4-yl)amino)cyclobutyl) methyl)carbamate


name: ASGR1_HUMAN Asialoglycoprotein receptor 1 (sprot)

description: An asialoglycoprotein receptor 1 that is encoded in the genome of human.


name: (E)-Methyl 3-(2-(N-(4-(6-(dimethylamino)pyridin-3-yl) benzyl)tetrahydro-2H-pyran-4-carboxamido) pyridin-4-yl)acrylate


name: Methyl 1-(N-((4''-methoxy-3''-methyl-[1,1''-biphenyl]-4-yl)methyl) cycloheptanecarboxamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-(4-(2,2-difluorobenzo[d][1,3] dioxol-5-yl)benzyl)-3,3-dimethylbutanamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-(4-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)benzyl)-3,3-dimethylbutanamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-((4''-methoxy-3''-methyl-[1,1''-biphenyl]-4-yl)methyl) cyclopentanecarboxamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-((trans-4-(3-methoxyphenyl) cyclohexyl)methyl)-3,3-dimethylbutanamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-((trans-4-(4-methoxyphenyl) cyclohexyl)methyl)-3,3-dimethylbutanamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-((trans-4-(4-chlorophenyl) cyclohexyl)methyl)-3,3-dimethylbutanamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-((trans-4-(4-methoxy-3-methylphenyl) cyclohexyl)methyl)-3,3-dimethylbutanamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-((trans-4-(4-methoxy-3-methylphenyl) cyclohexyl)methyl)cyclohexane-carboxamido) isoquinoline-6-carboxylate


name: Methyl 1-(N-((1-(4-methoxy-3-methylphenyl) piperidin-4-yl)methyl)-3,3-dimethylbutanamido) isoquinoline-6-carboxylate


tafamidis

A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.


L-thyroxine zwitterion

Zwitterionic form of L-thyroxine.


name: S29A1_MOUSE Equilibrative nucleoside transporter 1 (sprot)

description: An equilibrative nucleoside transporter 1 that is encoded in the genome of mouse.


name: 4-Methoxy-3-(pyridin-3-ylsulfamoyl)-benzoic acid methyl ester


name: HYES_PIG Bifunctional epoxide hydrolase 2 (sprot)


name: Synthesis of 4-[3-(2-fluoro-6-methoxy-benzoyl)indol-1-yl]benzoic acid


name: Synthesis of 4-[3-[[2-chloro-6-(trifluoromethyl)phenyl]methyl]indol-1-yl]-2-hydroxy-benzoic acid


name: Synthesis of 4-[3-(2-fluoro-6-methoxy-benzoyl)indazol-1-yl]benzoic acid


name: (2-{3-[(3,5-Bis-trifluoromethyl-benzoyl)-methyl-amino]-pyridin-4-yl}-5-fluoro-phenoxy)-acetic acid methyl ester


name: N-[4-(2-Chloro-phenyl)-pyridin-3-yl]-N-methyl-5-trifluoromethyl-isophthalamic acid methyl ester


name: 3-{3-[(3,5-Bis-trifluoromethyl-benzoyl)-methyl-amino]-pyridin-4-yl}-4-methyl-benzoic acid methyl ester


name: {(3,5-Bis-trifluoromethyl-benzoyl)-[4-(2-chloro-phenyl)-pyridin-3-yl]-amino}-acetic acid methyl ester


name: (2-{(3,5-Bis-trifluoromethyl-benzoyl)-[4-(2-chloro-phenyl)-pyridin-3-yl]-amino}-ethyl)-carbamic acid benzyl ester


name: [(3-Methanesulfonyl-5-trifluoromethyl-benzoyl)-(2-methoxy-[3,4']bipyridinyl-3'-yl)-amino]-acetic acid methyl ester


name: {(3,5-Bis-trifluoromethyl-benzoyl)-[4-(4,5-difluoro-2-methoxy-phenyl)-pyridin-3-yl]-amino}-acetic acid methyl ester


name: [[4-(2-Fluoro-phenyl)-pyridin-3-yl]-(3-methanesulfonyl-5-trifluoromethyl-benzoyl)-amino]-acetic acid methyl ester


name: [[4-(2-Chloro-phenyl)-pyridin-3-yl]-(3-methanesulfonyl-5-trifluoromethyl-benzoyl)-amino]-acetic acid methyl ester


name: A9CPF9_ALLMI Heat shock protein 75 (trembl)


name: VACHT_HUMAN Vesicular acetylcholine transporter (sprot)

description: A vesicular acetylcholine transporter that is encoded in the genome of human.


name: ATRIP_HUMAN ATR-interacting protein (sprot)

description: An ATR-interacting protein that is encoded in the genome of human.


A  macrolide that is the 7-oxo derivative of zeaenol (the 5E stereoisomer). Isolated from Fungi, it exhibits cytotoxic,  antibacterial and inhibitory activity against NF-kappaB.


ZEAENOL

A macrolide that is a 14-memebered macrocycle fused to a 3-methoxyphenol ring. Isolated from Fungi and Cochliobolus lunatus, it exhibits antibacterial and inhibitory activity against NF-kappaB.


HYPOTHEMYCIN

A macrolide that is isolated from the cultured broth of Hypomyces subiculosus and shows antifungal activity and inhibits the growth of some human cancer cells.


name: {[(2S)-4-methyl-2-({[4-(trifluoromethyl)phenyl] carbamoyl}amino)pentanoyl] amino}acetic acid


name: {[(2S)-2-{[(4-bromophenyl)carbamoyl] amino}4-methylpentanoyl]amino} methanesulfonic acid


name: 5-(4-Bromo-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacyclo-octa[cd] inden-1-yl) benzo[d] oxazol-2-amine


name: (S)-2-((1-(2-amino-benzo[d] oxazol-5-yl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacyclo-octa[cd] inden-4-yl)oxy) propanamide


name: 3-allyl 7-methyl 8-hydroxy-5-oxo-4,5-dihydro-1H-chromeno[3,4-c]pyridine-3, 7(2H)-dicarboxylate


A tripeptide resulting from the formal condensation of the carboxy group of N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valine with the amino group of benzyl (2E,4S)-4-(L-leucylamino)-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate. It is an inhibitor of the main protease of SARS-CoV-2.


tideglusib

A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.


name: 4-[(Tetrahydropyran-4-ylmethyl)amino]benzene-1,3-disulfonic acid 3-amide 1-[(4-ethylphenyl)isobutylamide]


name: HS90A_BOVIN Heat shock protein HSP 90-alpha (sprot)

description: A heat shock protein HSP 90-alpha that is encoded in the genome of cow.


name: TMPS2_HUMAN Transmembrane protease serine 2 (sprot)

description: A transmembrane protease serine 2 that is encoded in the genome of human.


ANACARDIC ACID

A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities.


name: ADPRS_HUMAN ADP-ribosylhydrolase ARH3 (sprot)

description: An ADP-ribosylhydrolase ARH3 that is encoded in the genome of human.


name: UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 7 that is encoded in the genome of human.


name: SUV92_HUMAN Histone-lysine N-methyltransferase SUV39H2 (sprot)

description: A histone-lysine N-methyltransferase SUV39H2 that is encoded in the genome of human.


DCNL1_HUMAN DCN1-like protein 1 (sprot)

A DCN1-like protein 1 that is encoded in the genome of human.


KLKB1_RAT Plasma kallikrein (sprot)

A plasma kallikrein that is encoded in the genome of rat.


name: Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-hydroxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2 inverted exclamation marka-bipyridin]-3-yl)amino]-


name: US10517858, Example 58 (Diastereoisomer 1)


name: US10517858, Example 63 (Diastereoisomer 1)


name: US10517858, Example 63 (Diastereoisomer 3)


name: US10517858, Example 63 (Diastereoisomer 4)


name: US10517858, Example 66 (Diastereoisomer 1)


name: 3,5-Dimethyl-4-[1-propylsulfonyl-3-[1-(2,2,2-trifluoroethyl) pyrazol-4-yl]pyrrolo [3,2-b]pyridin-6-yl] isoxazole


name: HINT1_HUMAN Adenosine 5'-monophosphoramidase HINT1 (sprot)

description: An adenosine 5'-monophosphoramidase HINT1 that is encoded in the genome of human.


name: GRIA1_HUMAN Glutamate receptor 1 (sprot)

description: A glutamate receptor 1 that is encoded in the genome of human.


A member of the class of indazoles that is 1H-indazole substituted by pyridin-4-yl and {[(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidin-3-yl]carbonyl}amino groups at positions 3 and 5, respectively. It is a potent inhibitor of mitogen-activated protein kinases ERK1 and ERK2 (IC50 = 4 and 1 nM, respectively) that exhibits anti-cancer properties.


lorlatinib

A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.


name: UBAC1_HUMAN Ubiquitin-associated domain-containing protein 1 (sprot)

description: A ubiquitin-associated domain-containing protein 1 that is encoded in the genome of human.


name: ORTH5_ARATH E3 ubiquitin-protein ligase ORTHRUS 5 (sprot)

description: A protein that is a translation product of the ORTH5 gene in Arabidopsis thaliana.


name: 4-[2-(4-Fluoro-phenyl)-4-oxo-thiazolidin-3-yl]-3-methyl-benzoic acid propyl ester


name: 4-[2-(4-Fluoro-phenyl)-4-oxo-thiazolidin-3-yl]-3-methyl-benzoic acid isopropyl ester


name: 4-[2-(4-Fluoro-phenyl)-4-oxo-thiazolidin-3-yl]-3-methyl-benzoic acid adamantan-1-ylmethyl ester


name: BLKPC_KLEOX Carbapenem-hydrolyzing beta-lactamase KPC (sprot)


name: [(R,R) or (R,S) or (S,S) or (S,R)]-5-(9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl)-3-methyl-3-(oxetan-2-ylmethyl)indolin-2-one


name: R1AB_CVH22 Replicase polyprotein 1ab (sprot)


HYPEROSIDE

A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.


quercetin 3-O-beta-D-fucopyranoside

A quercetin O-glycoside that is  quercetin  attached to a beta-D-fucopyranosyl moiety at position 3 via a glycosidic linkage.


SCIADOPITISIN

A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.


GINKGETIN

A biflavonoid that is the  7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2.


A primary amino compound that is ethane-1,2-diamine in which the hydrogen on one of the amino groups is replaced by a 2-(aziridin-1-yl)ethyl group. It is a angiotensin-converting enzyme 2 (ACE2) inhibitor and a potential therapeutic agent for treating SARS coronavirus infections.


hydroxychloroquine

An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.


A member of the class of benzotriazoles that is 1H-benzotriazole which is substituted by a 2-oxo-2-{(4-propanamidophenyl)[(thiophen-3-yl)methyl]amino}ethyl group at position 1.  It is a 3C-like protease inhibitor of SARS-CoV and bat coronavirus HKU4.


A member of the class of benzotriazoles that is 1H-benzotriazole which is substituted by a 2-{[4-(2-methylpropanamido)phenyl][(thiophen-3-yl)methyl]amino}-2-oxoethyl group at position 1. It is a 3C-like protease inhibitor of SARS-CoV and bat coronavirus HKU4.


SAVININ

A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 1,3-benzodioxol-5-ylmethylidene group at position 3 and a 1,3-benzodioxol-5-ylmethyl group at position 4 (the 3E,4R-isomer). It exhibits antiviral activity against SARS-CoV-2.


name: R1AB_MERS1 Replicase polyprotein 1ab (sprot)


remdesivir

A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.


molnupiravir

A nucleoside analogue that is N(4)-hydroxycytidine in which the 5'-hydroxy group is replaced by a (2-methylpropanoyl)oxy group. It is the prodrug of the active antiviral ribonucleoside analog N(4)-hydroxycytidine (EIDD-1931), has activity against a number of RNA viruses including SARS-CoV-2, MERS-CoV, and seasonal and pandemic influenza viruses. It is currently in phase III trials for the treatment of patients with COVID-19.


mefloquine

An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.


amodiaquine

A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.


gemcitabine

A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.


TERCONAZOLE

A 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-isopropylpiperazine in which positions 2 and 4 of the 1,3-dioxolane moiety have R and S configuration, respectively.


Src kinase inhibitor I

A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a  potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases.


name: KSR2_HUMAN Kinase suppressor of Ras 2 (sprot)

description: A kinase suppressor of Ras 2 that is encoded in the genome of human.


name: PAR2_HUMAN Proteinase-activated receptor 2 (sprot)

description: A proteinase-activated receptor 2 that is encoded in the genome of human.


name: ATS6_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 6 (sprot)

description: An a disintegrin and metalloproteinase with thrombospondin motifs 6 that is encoded in the genome of human.


A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.


ANIDULAFUNGIN

A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.


ivacaftor

An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.


dronedarone

A member of the class of  1-benzofurans used for the treatment of  cardiac arrhythmias.


name: US10550102, Example 61. b). (enantiomer-1)


name: PARPT_HUMAN Protein mono-ADP-ribosyltransferase TIPARP (sprot)

description: A protein mono-ADP-ribosyltransferase TIPARP that is encoded in the genome of human.


name: CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (sprot)

description: A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human.


name: Step 1. Synthesis of 2-bromo-6-fluoro-4-hydroxybenzaldehyde


name: HYPDH_HUMAN Hydroxyproline dehydrogenase (sprot)

description: A hydroxyproline dehydrogenase that is encoded in the genome of human.


3-oxocyclopentanecarboxylic acid

An alicyclic ketone that is oxocyclopentanone substituted at position 3 by a carboxy group.


name: ARHG8_HUMAN Neuroepithelial cell-transforming gene 1 protein (sprot)

description: A neuroepithelial cell-transforming gene 1 protein that is encoded in the genome of human.


name: Q498M6_RAT Neuroepithelial cell transforming 1 (trembl)


name: FGF4_HUMAN Fibroblast growth factor 4 (sprot)

description: A fibroblast growth factor 4 that is encoded in the genome of human.


name: AA3R_MOUSE Adenosine receptor A3 (sprot)

description: An adenosine receptor A3 that is encoded in the genome of mouse.


name: PERE_HUMAN Eosinophil peroxidase (sprot)

description: An eosinophil peroxidase that is encoded in the genome of human.


name: DGLA_HUMAN Diacylglycerol lipase-alpha (sprot)

description: A diacylglycerol lipase-alpha that is encoded in the genome of human.


name: DGLB_HUMAN Diacylglycerol lipase-beta (sprot)

description: A diacylglycerol lipase-beta that is encoded in the genome of human.


name: CRT_PLAFA Chloroquine resistance transporter (sprot)


name: VGLI_HCMVA UL37 immediate early glycoprotein (sprot)


name: PPCEL_HUMAN Prolyl endopeptidase-like (sprot)

description: A prolyl endopeptidase-like that is encoded in the genome of human.


name: OTU7B_HUMAN OTU domain-containing protein 7B (sprot)

description: An OTU domain-containing protein 7B that is encoded in the genome of human.


name: ADRB1_MOUSE Beta-1 adrenergic receptor (sprot)

description: A beta-1 adrenergic receptor that is encoded in the genome of mouse.


name: Synthesis of (1R,5S,9r)-tert-butyl 9-(3-hydroxphenyl)-9-methoxy-3-azabicyclo[3.3.1]nonane-3-carboxylate


name: Synthesis of 2-fluoro-3-((1R,5S,9r)-9-methoxy-3-methyl-3-azabicyclo[3.3.1]nonan-9-yl)phenyl trifluoromethanesulfonate


name: Synthesis of 3-((1R,5S,9r)-3-cyclobutyl-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride


name: Synthesis of 3-((1R,5S,9r)-9-methoxy-3-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride


name: Synthesis of 1-((tetrahydro-2H-pyran-2-yl)oxy)cyclopropanecarboxylic acid


name: Synthesis of 4-((1R,5S,9r)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)picolinamide hydrochloride


name: Synthesis of 4-((1R,5S,9r)-9-methoxy-3-propyl-3-azabicyclo[3.3.1]nonan-9-yl)picolinamide hydrochloride


name: Synthesis of tert-butyl (3-phenylbicyclo[1.1.1]pentan-1-yl)carbamate


name: Synthesis of 4-((1R,5S,9r)-3-((1H-indol-3-yl)methyl)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)picolinamide hydrochloride


name: Synthesis of 3-((1R,5S,9r)-9-methoxy-3-(2-methoxyethyl)-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride


name: Synthesis of 3-((1R,5S,9r)-3-(2-cyclopropylethyl)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride


name: Synthesis of 3-((1R,5S,9r)-9-methoxy-3-(2-(methylsulfonyl)ethyl)-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride


name: GNRR2_CHLAE Gonadotropin-releasing hormone II receptor (sprot)


name: Q5U7L3_RABIT Gonadotropin-releasing hormone receptor (trembl)


name: RLBP1_BOVIN Retinaldehyde-binding protein 1 (sprot)


name: US10640533, Identification number CX13-103


name: CTRL_HUMAN Chymotrypsin-like protease CTRL-1 (sprot)

description: A chymotrypsin-like protease CTRL-1 that is encoded in the genome of human.


name: TM11D_HUMAN Transmembrane protease serine 11D (sprot)

description: A transmembrane protease serine 11D that is encoded in the genome of human.


name: US10640533, Identification number CX13-104


name: US10640533, Identification number CX13-105


name: US10640533, Identification number CX13-107


name: US10640533, Identification number CX13-130


name: US10640533, Identification number CX13-133


name: US10640533, Identification number CX13-135


name: US10640533, Identification number CX13-137


name: US10640533, Identification number CX13-600


A member of the class of methylindoles that is 1H-indole substituted by (2S)-butan-2-yl, methyl, N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]acetamide, and 6-(piperazin-1-yl)pyridin-3-yl groups at positions 1, 3, 4, and 6, respectively. It is a potent and highly selective inhibitor of EZH2 methyltransferase (IC50 = 9.9 nM).


A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.


OLTIPRAZ

A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.


capivasertib

An aminopiperidine that is piperidine substituted by 7H-pyrrolo[2,3-d]pyrimidin-4-yl, amino, and [(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]aminocarbonyl groups at positions 1, 4, and 4, respectively. It is a pan-AKT kinase inhibitor used in combination with fulvestrant for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations.


name: ABHD6_HUMAN Monoacylglycerol lipase ABHD6 (sprot)

description: A monoacylglycerol lipase ABHD6 that is encoded in the genome of human.


apremilast

A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.


name: F1L1D9_ASCSU Resistance to inhibitors of cholinesterase protein 3 (trembl)


name: 2-(((1s,4s)-4-(((4-Fluorophenyl)(phenyl) carbamoyloxy)methyl) cyclohexyl)methoxy)acetic acid


name: AT1B2_HUMAN Sodium/potassium-transporting ATPase subunit beta-2 (sprot)

description: A sodium/potassium-transporting ATPase subunit beta-2 that is encoded in the genome of human.


name: AT1B3_HUMAN Sodium/potassium-transporting ATPase subunit beta-3 (sprot)

description: A sodium/potassium-transporting ATPase subunit beta-3 that is encoded in the genome of human.


name: SFTA1_HUMAN Pulmonary surfactant-associated protein A1 (sprot)

description: A pulmonary surfactant-associated protein A1 that is encoded in the genome of human.


name: [3-[6-[(3-Chlorophenyl) methylamino] imidazo[1,2-b]pyridazin-3-yl]phenyl] methanol


name: [4-[6-[(4-Fluorophenyl) methylamino] imidazo[1,2-b]pyridazin-3-yl]phenyl] methanol


name: 4-[6-[(3,4-Dichlorophenyl) methylamino] imidazo[1,2-b]pyridazin-3-yl]benzoic acid


name: [2-[3-(Dimethylamino) anilino]-5,7-dihydropyrrolo [3,4-d]pyrimidin-6-yl]-(2-methoxyphenyl) methanone


name: N,N-dimethyl-3-[2-[2-(4-sulfamoylphenyl) ethylamino] imidazo[2,1-a] [1,3,4]thiadiazol-5-yl]benzamide


name: 1-[3-[2-[(4-Hydroxycyclo-hexyl)amino] imidazo[2,1-a] [1,3,4]thiadiazol-5-yl]phenyl] ethanone


name: N-[3-[2-(2-furylmethylamino) imidazo[2,1-a] [1,3,4]thiadiazol-5-yl]phenyl] acetamide


name: 3-[2-[(4-fluorophenyl) methylamino] imidazo[2,1-b] [1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide


name: N-[3-[2-(2-thienylmethyl-amino)imidazo [2,1-b] [1,3,4]thiadiazol-5-yl]phenyl] acetamide


name: 4-[[5-[3-(Dimethylamino) phenyl]imidazo [2,1-a] [1,3,4]thiadiazol-2-yl]amino] cyclohexanol


name: N-[3-[2-(isobutylamino) imidazo[2,1-b] [1,3,4]thiadiazol-5-yl]phenyl] methane-sulfonamide


name: 4-[2-[[5-(6-Methoxy-3-pyridyl)imidazo [2,1-b] [1,3,4]thiadiazol-2-yl]amino] ethyl]benzene-sulfonamide


name: N-[3-[6-[3-(trifluoromethoxy) phenyl]imidazo [1,2-b]pyridazin-3-yl]phenyl] acetamide


name: N-[3-[3-(3-acetamidophenyl) imidazo[1,2-b] pyridazin-6-yl]phenyl] acetamide


name: 3-[2-[(4-methoxyphenyl) methylamino] imidazo[2,1-b] [1,3,4]thiadiazol-5-yl]-N,N-dimethyl-benzamide


name: N-[3-[3-[3-(hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] acetamide


name: N-[3-[3-[4-(hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] methane-sulfonamide


name: [4-[3-[3-(Hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] methanol


name: [3-[6-[(4-Fluorophenyl) methyl]imidazo [1,2-b]pyridazin-3-yl]phenyl] methanol


name: N-[3-[6-[4-(hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-3-yl]phenyl] acetamide


name: N-[3-[6-[3-(trifluoromethyl) phenyl]imidazo [1,2-b]pyridazin-3-yl]phenyl] acetamide


name: 1-[3-[3-[3-(Hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] ethanone


name: 1-[3-[6-[3-(Dimethylamino) phenyl]imidazo [1,2-b]pyridazin-3-yl]phenyl] ethanone


name: N-[3-[3-[3-hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] methane-sulfonamide


name: N-[4-[3-[4-(hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] acetamide


name: 1-[3-[6-[3-(Hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-3-yl]phenyl] ethanone


name: N-[3-[3-[4-(hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] acetamide


name: [4-[3-[4-(Hydroxymethyl) phenyl]imidazo [1,2-b]pyridazin-6-yl]phenyl] methanol


name: 4-[[5-(3-Chloro-4-fluoro-phenyl)imidazo [2,1-b][1,3,4] thiadiazol-2-yl]amino] cyclohexanol


name: 4-[2-[[5-(3,4-Dimethoxyphenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2-yl]amino] ethyl]benzene-sulfonamide


name: 5-(3,4-dimethoxy-phenyl)-N-[2-(4-pyridyl) ethyl]imidazo [2,1-b][1,3,4] thiadiazol-2-amine


name: 4-[2-[[5-(3-Pyridyl)imidazo [2,1-d][1,3,4] thiadiazol-2-yl]amino]ethyl] benzene-sulfonamide


name: [4-[2-[(4-Methoxyphenyl) methylamino] imidazo[2,1-b] [1,3,4]thiadiazol-5-yl]phenyl] methanol


name: N-[3-[2-[2-(4-pyridyl)ethyl-amino]imidazo [2,1-b][1,3,4] thiadiazol-5-yl]phenyl] acetamide


name: 4-[[5-(6-Methoxy-3-pyridyl) imidazo[2,1-b] [1,3,4]thiadiazol-2-yl]amino] cyclohexanol


name: 1-[5-[2-(2-Morpholinoethyl-amino)imidazo [2,1-b][1,3,4] thiadiazol-5-yl]-2-thienyl] ethanone


name: N-[3-[2-(cyclohexylamino) imidazo[2,1-b] [1,3,4]thiadiazol-5-yl]phenyl] methane-sulfonamide


name: 4-[[5-(3-Fluorophenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2-yl]amino] cyclohexanol


name: 4-[[5-(3,4-Dimethoxyphenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2-yl]amino] cyclohexanol


name: 1-[3-[2-(Isobutyl-amino)imidazo [2,1-a][1,3,4] thiadiazol-5-yl]phenyl] ethanone


name: N-[(4-methoxyphenyl) methyl]-5-(5-methoxy-3-pyridyl)imidazo [2,1-3][1,3,4] thiadiazol-2-amine


name: 8-(2,5-dimethoxy-phenyl)-7-(4-fluorophenyl)-1-methyl-3H-imidazo [1,2-g]purine-2,4-dione [Also listed as: 6-(2,5-dimethoxy-phenyl)-7-(4-fluorophenyl)-4-methyl-purino[7,8-a]imidazole-1,3-dione:


name: ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (sprot)

description: An ectonucleotide pyrophosphatase/phosphodiesterase family member 1 that is encoded in the genome of human.


perampanel

A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.


name: T53I2_HUMAN Tumor protein p53-inducible nuclear protein 2 (sprot)

description: A tumor protein p53-inducible nuclear protein 2 that is encoded in the genome of human.


name: TIF1A_HUMAN Transcription intermediary factor 1-alpha (sprot)

description: A transcription intermediary factor 1-alpha that is encoded in the genome of human.


name: PADI4_MOUSE Protein-arginine deiminase type-4 (sprot)

description: A protein-arginine deiminase type-4 that is encoded in the genome of mouse.


sphingosine 1-phosphate

A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1


name: FABPH_HUMAN Fatty acid-binding protein, heart (sprot)

description: A fatty acid-binding protein, heart that is encoded in the genome of human.


name: [4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl] 2-methylpropyl hydrogen phosphate


name: [4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl] ethyl hydrogen phosphate


name: [4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl] cyclopentyl hydrogen phosphate


name: [4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl] 2-phenylethyl hydrogen phosphate


name: [4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl] pyridin-3-ylmethyl hydrogen phosphate


name: [4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl] pyridin-4-ylmethyl hydrogen phosphate


name: RAGE_HUMAN Advanced glycosylation end product-specific receptor (sprot)

description: An advanced glycosylation end product-specific receptor that is encoded in the genome of human.


CATH_HUMAN Pro-cathepsin H (sprot)

A cathepsin H that is encoded in the genome of human.


CATF_HUMAN Cathepsin F (sprot)

A cathepsin F that is encoded in the genome of human.


name: STING_HUMAN Stimulator of interferon genes protein (sprot)

description: A transmembrane protein 173 that is encoded in the genome of human.


name: PADI1_HUMAN Protein-arginine deiminase type-1 (sprot)

description: A protein-arginine deiminase type-1 that is encoded in the genome of human.


name: PADI2_MOUSE Protein-arginine deiminase type-2 (sprot)

description: A protein-arginine deiminase type-2 that is encoded in the genome of mouse.


beta-aminopropionitrile

An aminopropionitrile carrying an amino group at the beta-position.


name: LOXL2_HUMAN Lysyl oxidase homolog 2 (sprot)

description: A lysyl oxidase homolog 2 that is encoded in the genome of human.


AQP9_HUMAN Aquaporin-9 (sprot)

An aquaporin-9 that is encoded in the genome of human.


name: Rac-cis-2-((5-fluoro-2-(2-methoxy-7-methyl quinoxalin-5-yl)benzo[d]thiazol-6-yl)oxy) cyclohexyl pyridin-3-ylcarbamate


A sulfonamide resulting from the formal condensation of the amino group of 2-aminobenzothiazole with the sulfo group of 4-[(2-hydroxy-3-methoxybenzyl)amino]benzenesulfonic acid. It is an inhibitor of 12-lipoxygenase, being developed by Veralox Therapeutics for the treatment of heparin-induced thrombocytopenia and thrombosis.