diphenylpyraline

A member of the class of  piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.


mepyramine

An ethylenediamine derivative that is  ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.


methapyrilene

A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.


methdilazine

A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties.


nortriptyline

An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of  amitriptyline.


promazine

A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.


triflupromazine

A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position.


triprolidine

An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.


TRAMIPROSATE

An amino sulfonic acid that is the 3-amino derivative of propanesulfonic acid.


name: GABR1_RAT Gamma-aminobutyric acid type B receptor subunit 1 (sprot)

description: A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of rat.


bicuculline

A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.


name: Cyclopentanecarboxylic acid, 3-amino-, cis-


GABA

A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.


β-guanidinopropionic acid

A guanidine compound bearing an N-(2-carboxyethyl) substituent. It is a creatine analogue that has been found to decreases plasma glucose levels


MUSCIMOL

A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.


name: DRD1_BOVIN D(1A) dopamine receptor (sprot)

description: A D(1A) dopamine receptor that is encoded in the genome of cow.


azaperone

An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.


(S)-BULBOCAPNINE

An aporphine alkaloid that has been isolated from Corydalis and exhibits inhibitory activity against enzymes such as tyrosine 3-monooxygenase and diamine oxidase.


(E)-chlorprothixene

A chlorprothixene in which the double bond adopts an (E)-configuration.


zuclopenthixol

The (Z)-isomer of clopenthixol.


droperidol

An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.


methiothepin

A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).


pimozide

A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group.


pipamperone

A member of the class of  bipiperidines that is 1,4'-bipiperidine which is substituted at the 1' and 4' positions by 4-(p-fluorophenyl)-4-oxobutyl and carboxamide groups, respectively. A first generation antipsychotic, its properties are generally similar to those of haloperidol.


name: DRD2_BOVIN D(2) dopamine receptor (sprot)


methadone

A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.


pilocarpine

The (+)-enantiomer of pilocarpine.


name: ACM2_RAT Muscarinic acetylcholine receptor M2 (sprot)

description: A muscarinic acetylcholine receptor M2 that is encoded in the genome of rat.


A member of the class of tryptamines that is the methyl ether derivative of serotonin.


A pyrroloquinoxaline that is pyrrolo[1,2-a]quinoxaline bearing additional 4-methylpiperazin-1-yl and trifluoromethyl substituents at positions 4 and 7 respectively. A 5-hydroxytryptamine receptor 1B (5-HT1B) full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Centrally active following systemic administration.


m-chlorophenylpiperazine

A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.


mesulergine

A member of the class of ergot alkaloids that is known to act on serotonin and dopamine receptors.


sumatriptan

A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.


TFMPP

A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.


name: 1H-indole-3-carboxylic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester


name: 5HT3A_RAT 5-hydroxytryptamine receptor 3A (sprot)

description: A 5-hydroxytryptamine receptor 3A that is encoded in the genome of rat.


name: CHIA_HUMAN Acidic mammalian chitinase (sprot)

description: An acidic mammalian chitinase that is encoded in the genome of human.


name: SENP1_HUMAN Sentrin-specific protease 1 (sprot)

description: A sentrin-specific protease 1 that is encoded in the genome of human.


name: SENP2_HUMAN Sentrin-specific protease 2 (sprot)

description: A sentrin-specific protease 2 that is encoded in the genome of human.


name: SENP7_HUMAN Sentrin-specific protease 7 (sprot)

description: A sentrin-specific protease 7 that is encoded in the genome of human.


name: LT4R2_HUMAN Leukotriene B4 receptor 2 (sprot)

description: A leukotriene B4 receptor 2 that is encoded in the genome of human.


A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.


name: PACA_HUMAN Pituitary adenylate cyclase-activating polypeptide (sprot)

description: A pituitary adenylate cyclase-activating polypeptide that is encoded in the genome of human.


name: HRH1_CAVPO Histamine H1 receptor (sprot)


name: HRH2_CAVPO Histamine H2 receptor (sprot)


name: HRH3_CAVPO Histamine H3 receptor (sprot)


name: TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)

description: A DNA topoisomerase 2-alpha that is encoded in the genome of human.


name: HIPK2_HUMAN Homeodomain-interacting protein kinase 2 (sprot)

description: A homeodomain-interacting protein kinase 2 that is encoded in the genome of human.


A dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a [2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino substituent.  It is an inhibitor of the BMK1 kinase pathway.


name: MGRA_STAAU HTH-type transcriptional regulator MgrA (sprot)

description: A protein that is a translation product of the mgrA gene in Staphylococcus aureus.


A bis(5'-adenosyl)-triphosphatase that is encoded in the genome of human.


name: MURD_LEPIN UDP-N-acetylmuramoylalanine--D-glutamate ligase (sprot)


name: Benzene 1,3-dicarvboxylic acid inhibitor


name: LPXC_PSEAE UDP-3-O-acyl-N-acetylglucosamine deacetylase (sprot)


name: SRC_MOUSE Proto-oncogene tyrosine-protein kinase Src (sprot)

description: A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of mouse.


name: PDCL3_HUMAN Phosducin-like protein 3 (sprot)

description: A phosducin-like protein 3 that is encoded in the genome of human.


name: TBA1A_PIG Tubulin alpha-1A chain (sprot)


name: PACA_RAT Pituitary adenylate cyclase-activating polypeptide (sprot)

description: A pituitary adenylate cyclase-activating polypeptide that is encoded in the genome of rat.


name: SSR1_HUMAN Somatostatin receptor type 1 (sprot)

description: A somatostatin receptor type 1 that is encoded in the genome of human.


somatostatin

A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.


name: SSR2_MOUSE Somatostatin receptor type 2 (sprot)

description: A somatostatin receptor type 2 that is encoded in the genome of mouse.


name: SSR3_MOUSE Somatostatin receptor type 3 (sprot)

description: A somatostatin receptor type 3 that is encoded in the genome of mouse.


name: ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)

description: A muscarinic acetylcholine receptor M1 that is encoded in the genome of human.


biperiden

A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.


mesoridazine

A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group.


procyclidine

A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.


risperidone

A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.


name: ACM4_HUMAN Muscarinic acetylcholine receptor M4 (sprot)

description: A muscarinic acetylcholine receptor M4 that is encoded in the genome of human.


domperidone

1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.


ritanserin

A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.


amperozide

A member of the class of ureas that is urea in which three of the four hydrogens are replaced by ethyl and 4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl groups. An atypical antipsychotic which was in clinical development for the treatment of schizophrenia and substance-related disorders. It is a potent 5-HT2A antagonist and used in veterinary medicine because of its sedative effect on pigs.


name: 5HT2C_RAT 5-hydroxytryptamine receptor 2C (sprot)

description: A 5-hydroxytryptamine receptor 2C that is encoded in the genome of rat.


name: ADA2C_RAT Alpha-2C adrenergic receptor (sprot)

description: An alpha-2C adrenergic receptor that is encoded in the genome of rat.


name: ADA2A_HUMAN Alpha-2A adrenergic receptor (sprot)

description: An alpha-2A adrenergic receptor that is encoded in the genome of human.


AKUAMMIGINE

A monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from Vinca sardoa and Uncaria rhynchophylla.


name: ADA2B_HUMAN Alpha-2B adrenergic receptor (sprot)

description: An alpha-2B adrenergic receptor that is encoded in the genome of human.


name: ADA2B_RAT Alpha-2B adrenergic receptor (sprot)

description: An alpha-2B adrenergic receptor that is encoded in the genome of rat.


name: ADA2C_HUMAN Alpha-2C adrenergic receptor (sprot)

description: An alpha-2C adrenergic receptor that is encoded in the genome of human.


NAPTALAM

A dicarboxylic acid monoamide which results from addition of one equivalent of 1-naphthylamine to phthalic anhydride.


quinpirole

A pyrazoloquinoline that is  (4aR,8aR)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline substituted by a propyl group at position 5. It acts as a dopamine agonist.


A 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol that is the R-enantiomer of SKF 38393.


(-)-sulpiride

An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, D1 and D5 receptors respectively).


(+)-sulpiride

An optically active form of sulpiride having (R)-configuration. The active enantiomer of the racemic drug sulpiride.


name: SSR4_RAT Somatostatin receptor type 4 (sprot)

description: A somatostatin receptor type 4 that is encoded in the genome of rat.


A heterodetic cyclic peptide consisting of somatostatin in which the amino terminus has been acylated by the fourteen membered peptide Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys.


name: ADCY2_RAT Adenylate cyclase type 2 (sprot)

description: An adenylate cyclase type 2 that is encoded in the genome of rat.


name: DRD1_RAT D(1A) dopamine receptor (sprot)

description: A D(1A) dopamine receptor that is encoded in the genome of rat.


name: 5HT5A_MOUSE 5-hydroxytryptamine receptor 5A (sprot)

description: A 5-hydroxytryptamine receptor 5A that is encoded in the genome of mouse.


bufotenine

A tertiary amine that consists of N,N-dimethyltryptamine bearing an additional hydroxy substituent at position 5.


name: 5HT1B_RAT 5-hydroxytryptamine receptor 1B (sprot)

description: A 5-hydroxytryptamine receptor 1B that is encoded in the genome of rat.


DOI

An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.


tryptamine

An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.


AA1R_RAT Adenosine receptor A1 (sprot)

An adenosine receptor A1 that is encoded in the genome of rat.


pindolol

A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.


name: 5HT1D_HUMAN 5-hydroxytryptamine receptor 1D (sprot)

description: A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human.


amisulpride

A member of the class of benzamides resulting from the formal condensation of the carboxy group of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid with the primary amino group of 2-(aminomethyl)-1-ethylpyrrolidine. It is a potent, selective dopamine D2 and D3 receptor antagonist. It is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects.


pergolide

A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.


thioproperazine

A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.


A secondary amino compound that consists of tetralin bearing methyl, propylamino and methoxy groups at positions 1, 2 and 5 respectively. Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).


name: DRD3_HUMAN D(3) dopamine receptor (sprot)

description: A D(3) dopamine receptor that is encoded in the genome of human.


name: ADA1A_BOVIN Alpha-1A adrenergic receptor (sprot)

description: An alpha-1A adrenergic receptor that is encoded in the genome of cow.


methoctramine

A tetramine that is N,N'-bis(6-aminohexyl)octane-1,8-diamine where the primary amino groups both carry 2-methoxybenzyl substituents.


A quaternary ammonium salt obtained by formal methylation of the tertiary amino function of 4-diphenylacetoxy-N-methylpiperidine.


DPEP1_PIG Dipeptidase 1 (sprot)

A dipeptidase 1 that is encoded in the genome of pig.


LEUKOTRIENE D4

A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).


LEUKOTRIEN E4

A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and an L-cystein-S-yl group at position 6 (6R).


idazoxan

A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group.


tizanidine

2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group.  It is an agonist at alpha2-adrenergic receptor sites.


name: ADA2C_DIDVI Alpha-2C adrenergic receptor (sprot)


A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.


name: 5HT3A_MOUSE 5-hydroxytryptamine receptor 3A (sprot)

description: A 5-hydroxytryptamine receptor 3A that is encoded in the genome of mouse.


name: AA1R_BOVIN Adenosine receptor A1 (sprot)

description: An adenosine receptor A1 that is encoded in the genome of cow.


name: ORAI1_HUMAN Calcium release-activated calcium channel protein 1 (sprot)

description: A calcium release-activated calcium channel protein 1 that is encoded in the genome of human.


name: ACM3_RAT Muscarinic acetylcholine receptor M3 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of rat.


name: CCR4_HUMAN C-C chemokine receptor type 4 (sprot)

description: A C-C chemokine receptor type 4 that is encoded in the genome of human.


name: N-Substituted indole-2-and 3-carboxamide derivative, 1


HYAL1_HUMAN Hyaluronidase-1 (sprot)

A hyaluronidase-1 that is encoded in the genome of human.


name: N-Substituted indole-2-and 3-carboxamide derivative, 2


name: N-Substituted indole-2-and 3-carboxamide derivative, 3


name: N-Substituted indole-2-and 3-carboxamide derivative, 6


name: N-Substituted indole-2-and 3-carboxamide derivative, 7


name: N-Substituted indole-2-and 3-carboxamide derivative, 8


name: N-Substituted indole-2-and 3-carboxamide derivative, 16


name: N-Substituted indole-2-and 3-carboxamide derivative, 17


name: N-Substituted indole-2-and 3-carboxamide derivative, 18


bethanechol

The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.


name: DRD5_RAT D(1B) dopamine receptor (sprot)

description: A D(1B) dopamine receptor that is encoded in the genome of rat.


An optically active form of nemonapride having (2S,3S)-configuration.


DRD4_RAT D(4) dopamine receptor (sprot)

A D(4) dopamine receptor that is encoded in the genome of rat.


name: DRD4_HUMAN D(4) dopamine receptor (sprot)

description: A D(4) dopamine receptor that is encoded in the genome of human.


alprazolam

A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.


diazepam

A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.


flunitrazepam

A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.


R-FLUOXETINE

An N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine that has R configuration. [The antidepressant drug fluoxetine is a racemate comprising equimolar amounts of (R)- and (S)-fluoxetine].


citalopram

A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer,  escitalopram. It is used as an antidepressant, although only escitalopram is active.


(S)-fluoxetine

An N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine that has S configuration. [The antidepressant drug fluoxetine is a racemate comprising equimolar amounts of (R)- and (S)-fluoxetine].


paroxetine

A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.


GRIA3_RAT Glutamate receptor 3 (sprot)

A glutamate receptor 3 that is encoded in the genome of rat.


name: NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (sprot)

description: A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of rat.


name: ADRB1_RAT Beta-1 adrenergic receptor (sprot)

description: A beta-1 adrenergic receptor that is encoded in the genome of rat.


name: ADRB2_RAT Beta-2 adrenergic receptor (sprot)

description: A beta-2 adrenergic receptor that is encoded in the genome of rat.


name: SGMR1_RAT Sigma non-opioid intracellular receptor 1 (sprot)

description: A sigma non-opioid intracellular receptor 1 that is encoded in the genome of rat.


OXYR_RAT Oxytocin receptor (sprot)

An oxytocin receptor that is encoded in the genome of rat.


CBPB2_HUMAN Carboxypeptidase B2 (sprot)

A carboxypeptidase B2 that is encoded in the genome of human.


name: DRD2_MOUSE D(2) dopamine receptor (sprot)

description: A D(2) dopamine receptor that is encoded in the genome of mouse.


name: AA1R_RABIT Adenosine receptor A1 (sprot)


name: AA1R_CAVPO Adenosine receptor A1 (sprot)

description: An adenosine receptor A1 that is encoded in the genome of guinea pig.


name: P2RY2_CRIGR P2Y purinoceptor 2 (Fragment) (sprot)


name: AA3R_SHEEP Adenosine receptor A3 (sprot)


CINANSERIN

An aryl sulfide that is (2E)-3-phenyl-N-(2-sulfanylphenyl)prop-2-enamide in which the hydrogen of the thiol group is substituted by a 3-(dimethylamino)propyl group. It is a 5-hydroxytryptamine receptor antagonist and an inhibitor of SARS-CoV replication.


name: PTAFR_HUMAN Platelet-activating factor receptor (sprot)

description: A mammalian-type platelet-activating factor receptor that is encoded in the genome of human.


apraclonidine

An imidazoline that is 2-amino 4,5-dihydro-1H-imidazoline in which one of the exocyclic amino hydrogens has been replaced by a 4-amino-2,6-dichlorophenyl group.


morphine

A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).


diltiazem

A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.


name: CAC1C_RAT Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of rat.


name: 2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester


verapamil

A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.


name: ACM4_MOUSE Muscarinic acetylcholine receptor M4 (sprot)

description: A muscarinic acetylcholine receptor M4 that is encoded in the genome of mouse.


ATP6_RAT ATP synthase subunit a (sprot)

An ATP synthase subunit a that is encoded in the genome of rat.


name: BHE22_MOUSE Class E basic helix-loop-helix protein 22 (sprot)

description: A class E basic helix-loop-helix protein 22 that is encoded in the genome of mouse.


SUBSTANCE P

A neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission.


TKN1_MOUSE Protachykinin-1 (sprot)

A protachykinin-1 that is encoded in the genome of mouse.


TKN1_RAT Protachykinin-1 (sprot)

A protachykinin-1 that is encoded in the genome of rat.


NK2R_CAVPO Substance-K receptor (sprot)

A protein that is a translation product of the TACR2 gene in guinea pig.


bupropion

An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring.


A methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have S configuration. It is the inactive enantiomer in the racemic drug methylphenidate.


nomifensine

An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.


MPP+

A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.


name: TA2R_HUMAN Thromboxane A2 receptor (sprot)

description: A thromboxane A2 receptor that is encoded in the genome of human.


name: 5-Heptenoic acid, 7-((1S,2R,4R,5S)-3-((1E,3S)-3-hydroxy-1-octenyl)-6-thiabicyclo(3.1.1)hept-2-yl)-, (5Z)-


name: S22A1_HUMAN Solute carrier family 22 member 1 (sprot)

description: A solute carrier family 22 member 1 that is encoded in the genome of human.


name: GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human.


name: GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of human.


A tertiary amino compound that is piperazine substituted by a benzyl group at position 1. It is a  serotonergic agonist used as a recreational drug.


name: S22A2_RAT Solute carrier family 22 member 2 (sprot)

description: A solute carrier family 22 member 2 that is encoded in the genome of rat.


dicyclomine

The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.


DEVAZEPIDE

An indolecarboxamide obtained by formal condensation of the carboxy group of indole-2-carboxylic acid with the exocyclic amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one. A cholecystokinin antagonist used for treatment of gastrointestinal disorders.


name: GASR_MOUSE Gastrin/cholecystokinin type B receptor (sprot)

description: A cholecystokinin receptor 2 that is encoded in the genome of mouse.


name: GASR_RAT Gastrin/cholecystokinin type B receptor (sprot)

description: A cholecystokinin receptor 2 that is encoded in the genome of rat.


name: GASR_CANLF Gastrin/cholecystokinin type B receptor (sprot)

description: A cholecystokinin receptor 2 that is encoded in the genome of dog.


name: ACM2_PIG Muscarinic acetylcholine receptor M2 (sprot)

description: A muscarinic acetylcholine receptor M2 that is encoded in the genome of pig.


A dihydroxyflavone that is  chrysin substituted by prenyl groups at positions 6 and 8 respectively.


dimethyltryptamine

A tryptamine derivative having two N-methyl substituents on the side-chain.


mescaline

A phenethylamine alkaloid that is phenethylamine substituted at positions 3, 4 and 5 by methoxy groups.


psilocin

A tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional hydroxy substituent at position 4. A hallucinogenic alkaloid isolated in trace amounts from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms").


PSILOCYBINE

A tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms").


A member of the class of  acetophenones that is acetophenone substituted by methoxy groups at positions 3, 4 and 5 respectively.


A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and the hydrogen at position 2 on the adenine is replaced by a 4-(2-carboxyethyl)phenethylamino group.


cyclohexylamine

A primary aliphatic amine consisting of cyclohexane carrying an amino substituent.


D-ASPARTATE

The D-enantiomer of aspartic acid.


kynurenic acid

A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.


L-aspartic acid

The L-enantiomer of aspartic acid.


name: ADA1A_RABIT Alpha-1A adrenergic receptor (sprot)

description: An alpha-1A adrenergic receptor that is encoded in the genome of rabbit.


name: ADA1A_CANLF Alpha-1A adrenergic receptor (Fragment) (sprot)


name: ADA1D_MOUSE Alpha-1D adrenergic receptor (sprot)

description: An alpha-1D adrenergic receptor that is encoded in the genome of mouse.


name: ADA2A_CAVPO Alpha-2A adrenergic receptor (sprot)


name: ADA2B_RABIT Alpha-2B adrenergic receptor (Fragment) (sprot)


name: SGMR1_CAVPO Sigma non-opioid intracellular receptor 1 (sprot)

description: A sigma non-opioid intracellular receptor 1 that is encoded in the genome of guinea pig.


phencyclidine

A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group.  Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.


name: ADA2B_DIDVI Alpha-2B adrenergic receptor (Fragment) (sprot)


name: DRD1_MOUSE D(1A) dopamine receptor (sprot)

description: A D(1A) dopamine receptor that is encoded in the genome of mouse.


name: ADA1A_HUMAN Alpha-1A adrenergic receptor (sprot)

description: An alpha-1A adrenergic receptor that is encoded in the genome of human.


fluvoxamine

An oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder.


trazodone

An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.


name: 5HT2C_CANLF 5-hydroxytryptamine receptor 2C (sprot)

description: A 5-hydroxytryptamine receptor 2C that is encoded in the genome of dog.


name: DRD2_CANLF D(2) dopamine receptor (sprot)

description: A D(2) dopamine receptor that is encoded in the genome of dog.


ketamine

A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.


(2S)-2-amino-4-phosphonobutanoic acid

A non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8).


PARAXANTHINE

A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals.


theobromine

A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.


enprofylline

Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.


A 1-methylxanthine tautomer where the imidazole proton is located at the 7-position.


METHYLTHIOADENOSINE

Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.


propionyl adenylate

A member of the class of  adenosines that is adenosine with the hydrogen on the 5'-hydroxy group replaced with a propanoyl group.


bepridil

A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.


DEVAPAMIL

A nitrile that acts as an L-type calcium channel blocker.


loperamide

A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.


name: 2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester


buspirone

An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.


name: AA1R_CHICK Adenosine receptor A1 (sprot)

description: An adenosine receptor A1 that is encoded in the genome of chicken.


venlafaxine

A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group.


RACEMETHORPHAN

An organic heterotetracyclic compound that is 1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene which is substituted by a methoxy group at position 6 and a methyl group at position 11.


(+)-SKF 10.047

The (+)-stereoisomer of SKF-10,047.


cimetidine

A member of the class of  guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a  H2-receptor antagonist that inhibits the production of acid in stomach.


ranitidine

A member of the class of  furans used to treat  peptic ulcer disease (PUD) and gastroesophageal reflux disease.


trimipramine

A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)-2-methylpropyl group at the nitrogen atom. It is used as an antidepressant.


pizotifen

A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.


name: OPRD_PIG Delta-type opioid receptor (Fragment) (sprot)


name: OPRD_MOUSE Delta-type opioid receptor (sprot)

description: A delta-type opioid receptor that is encoded in the genome of mouse.


name: OPRM_BOVIN Mu-type opioid receptor (sprot)

description: A mu-type opioid receptor that is encoded in the genome of cow.


name: OPRM_CAVPO Mu-type opioid receptor (Fragment) (sprot)


13,14-dihydro-15-oxo-prostaglandin E2

The 13,14-dihydro derivative of 15-oxo-prostaglandin E2.


A prostanoid that is 18,19,20-trinor-prostaglandin E2 in which one of the terminal methyl hydrogens has been replaced by a phenyl group.


name: CAH13_HUMAN Carbonic anhydrase 13 (sprot)

description: A carbonic anhydrase 13 that is encoded in the genome of human.


name: DYR_BOVIN Dihydrofolate reductase (sprot)

description: A protein that is a translation product of the DHFR gene in cow.


name: [(3S,2R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydroge n phosphate


name: BIP_HUMAN Endoplasmic reticulum chaperone BiP (sprot)

description: An endoplasmic reticulum chaperone BiP that is encoded in the genome of human.


FINC_HUMAN Fibronectin (sprot)

A fibronectin that is encoded in the genome of human.


name: ILVC_ECOLI Ketol-acid reductoisomerase (NADP(+)) (sprot)

description: A ketol-acid reductoisomerase (NADP(+)) that is encoded in the genome of Escherichia coli K-12.


name: COAD_ECOLI Phosphopantetheine adenylyltransferase (sprot)

description: A phosphopantetheine adenylyltransferase that is encoded in the genome of Escherichia coli K-12.


name: COAD_ENTFA Phosphopantetheine adenylyltransferase (sprot)


FERULATE

A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring.


gallic acid

A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.


SYRINGIC ACID

A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.


sulfacetamide

A sulfonamide that is sulfanilamide acylated on the sulfonamide nitrogen.


name: PON1_HUMAN Serum paraoxonase/arylesterase 1 (sprot)

description: A serum paraoxonase/arylesterase 1 that is encoded in the genome of human.


LEVULINIC ACID

An oxopentanoic acid with the oxo group in the 4-position.


name: HEM2_ECOLI Delta-aminolevulinic acid dehydratase (sprot)

description: A delta-aminolevulinic acid dehydratase that is encoded in the genome of Escherichia coli K-12.


monomethyl succinate

A dicarboxylic acid monoester that is succinic acid in which one of the carboxy groups has been converted to its methyl ester.


ACETURIC ACID

An N-acylglycine where the acyl group is specified as acetyl.


3-nitropropanoic acid

A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.


name: PI2R_MOUSE Prostacyclin receptor (sprot)

description: A prostacyclin receptor that is encoded in the genome of mouse.


THROMBOXANE B2

A member of the class of thromboxanes B that is (5Z,13E)-thromboxa-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15.


name: PD2R_RAT Prostaglandin D2 receptor (sprot)

description: A protein that is a translation product of the Ptgdrl gene in rat.


dinoprostone

Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.


name: TA2R_MOUSE Thromboxane A2 receptor (sprot)

description: A thromboxane A2 receptor that is encoded in the genome of mouse.


thromboxane A2

A thromboxane which is produced by activated platelets and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation.


CCKN_RAT Cholecystokinin (sprot)

A cholecystokinin that is encoded in the genome of rat.


An eight-membered oligopeptide consisting of Asp, Tyr, Met, Gly, Trp, Met, As and Phe-NH2 residues joined in sequence.


One of the primary forms of gastrin that is a 14-membered peptide consisting of Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe residues joined in sequence.


name: 5HT7R_CAVPO 5-hydroxytryptamine receptor 7 (sprot)

description: A protein that is a translation product of the HTR7 gene in guinea pig.


paliperidone

A member of the class of pyridopyrimidines that is 9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.


name: 5HT1D_RAT 5-hydroxytryptamine receptor 1D (sprot)

description: A 5-hydroxytryptamine receptor 1D that is encoded in the genome of rat.


name: SSR1_RAT Somatostatin receptor type 1 (sprot)

description: A somatostatin receptor type 1 that is encoded in the genome of rat.


name: SSR2_RAT Somatostatin receptor type 2 (sprot)

description: A somatostatin receptor type 2 that is encoded in the genome of rat.


name: SSR3_RAT Somatostatin receptor type 3 (sprot)

description: A somatostatin receptor type 3 that is encoded in the genome of rat.


name: SSR5_RAT Somatostatin receptor type 5 (sprot)

description: A somatostatin receptor type 5 that is encoded in the genome of rat.


name: AGTR2_RAT Type-2 angiotensin II receptor (sprot)

description: An angiotensin II receptor 2 that is encoded in the genome of rat.


losartan

A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position


NK1R_CAVPO Substance-P receptor (sprot)

A substance-P receptor that is encoded in the genome of guinea pig.


NK2R_HUMAN Substance-K receptor (sprot)

A substance-K receptor that is encoded in the genome of human.


dextropropoxyphene

The (1S,2R)-(+)-diastereoisomer of propoxyphene.


A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine.


memantine

A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.


name: MTR1A_HUMAN Melatonin receptor type 1A (sprot)

description: A melatonin receptor type 1A that is encoded in the genome of human.


name: MTR1B_HUMAN Melatonin receptor type 1B (sprot)

description: A melatonin receptor type 1B that is encoded in the genome of human.


name: 5HT2B_RAT 5-hydroxytryptamine receptor 2B (sprot)

description: A 5-hydroxytryptamine receptor 2B that is encoded in the genome of rat.


RS 39604

An aromatic ether that is the 3,5-dimethoxybenzyl derivative of N-(2-{4-[3-(4-amino-5-chloro-2-hydroxyphenyl)-3-oxopropyl]piperidin-1-yl}ethyl)methanesulfonamide. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.


name: 5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (sprot)

description: A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human.


name: 5HT4R_CAVPO 5-hydroxytryptamine receptor 4 (sprot)


name: SIGM1_REOVD Outer capsid protein sigma-1 (sprot)


name: SIGM2_REOVL Inner capsid protein sigma-2 (sprot)


name: NPY4R_HUMAN Neuropeptide Y receptor type 4 (sprot)

description: A neuropeptide Y receptor type 4 that is encoded in the genome of human.


name: NK3R_HUMAN Neuromedin-K receptor (sprot)

description: A neuromedin-K receptor that is encoded in the genome of human.


aripiprazole

An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.


N-methylserotonin

A member of the class of tryptamines that is serotonin in which one of the hydrogens attached to the primary amino group is replaced by a methyl group.


name: 5HT6R_RAT 5-hydroxytryptamine receptor 6 (sprot)

description: A 5-hydroxytryptamine receptor 6 that is encoded in the genome of rat.


decamethonium

A quaternary ammonium ion that is a depolarising muscle relaxant whose structure comprises a decane-1,10-diamine core in which each amino group carries three methyl substituents.


name: IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (sprot)

description: An inositol-trisphosphate 3-kinase A that is encoded in the genome of human.


PA21B_HUMAN Phospholipase A2 (sprot)

A phospholipase A2 that is encoded in the genome of human.


name: 5HT5A_RAT 5-hydroxytryptamine receptor 5A (sprot)

description: A 5-hydroxytryptamine receptor 5A that is encoded in the genome of rat.


name: 5HT5B_RAT 5-hydroxytryptamine receptor 5B (sprot)

description: A 5-hydroxytryptamine receptor 5B that is encoded in the genome of rat.


VIP_RAT VIP peptides (sprot)

A VIP peptides that is encoded in the genome of rat.


VIP_HUMAN VIP peptides (sprot)

A VIP peptides that is encoded in the genome of human.


XALIPRODEN

A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine which is substituted on the nitrogen by a 2-(2-naphthyl)ethyl group and at position 4 by a m-trifluoromethylphenyl group.


cyclopentolate

A carboxylic ester resulting from the formal condensation of (1-hydroxycyclopentyl)(phenyl)acetic acid with N,N-dimethylethanolamine. A tertiary amine antimuscarinic with actions similar to atropine, it is used as its hydrochloride salt to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis  of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action.


orphenadrine

A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.


AROXYBUTYNIN

A 4-(diethylamino)but-2-yn-1-ol that has R configuration. It is responsible for virtually all of the antimuscarinic activity of (racemic) oxybutynin.


name: ACM4_CHICK Muscarinic acetylcholine receptor M4 (sprot)

description: A muscarinic acetylcholine receptor M4 that is encoded in the genome of chicken.


periciazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.


ACTH

A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.


name: MSHR_HUMAN Melanocyte-stimulating hormone receptor (sprot)

description: A melanocyte-stimulating hormone receptor that is encoded in the genome of human.


name: MC3R_HUMAN Melanocortin receptor 3 (sprot)

description: A melanocortin receptor 3 that is encoded in the genome of human.


name: MC5R_HUMAN Melanocortin receptor 5 (sprot)

description: A melanocortin receptor 5 that is encoded in the genome of human.


NEUROTENSIN

A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.


name: 5HT4R_RAT 5-hydroxytryptamine receptor 4 (sprot)

description: A 5-hydroxytryptamine receptor 4 that is encoded in the genome of rat.


name: ADA1B_MESAU Alpha-1B adrenergic receptor (sprot)

description: A protein that is a translation product of the ADRA1B gene in Mesocricetus auratus.


name: S22A1_BOVIN Solute carrier family 22 member 1 (sprot)


fentanyl

A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.


Leu-enkephalin

A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.


sufentanil

An anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid.


NK2R_RAT Substance-K receptor (sprot)

A substance-K receptor that is encoded in the genome of rat.


name: NK3R_MOUSE Neuromedin-K receptor (sprot)

description: A neuromedin-K receptor that is encoded in the genome of mouse.


name: NK3R_CAVPO Neuromedin-K receptor (sprot)

description: A protein that is a translation product of the TACR3 gene in guinea pig.


A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.


name: SSR4_MOUSE Somatostatin receptor type 4 (sprot)

description: A somatostatin receptor type 4 that is encoded in the genome of mouse.


name: 3,5-dichlorobenzoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester


name: AGTRA_RAT Type-1 angiotensin II receptor A (sprot)

description: An angiotensin II receptor 1A that is encoded in the genome of rat.


eprosartan

A member of the class of  imidazoles and  thiophenes  that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.


name: ADA2A_BOVIN Alpha-2A adrenergic receptor (sprot)

description: An alpha-2A adrenergic receptor that is encoded in the genome of cow.


acetophenazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the nitogen atom and an acetyl group at position 2.


chlorpromazine N-oxide

An organochlorine compound that is chlorpromazine in which the acyclic tertiary amino group has been converted into the corresponding N-oxide.


name: ADRB2_CAVPO Beta-2 adrenergic receptor (sprot)

description: A beta-2 adrenergic receptor that is encoded in the genome of guinea pig.


fenoterol

A member of the class  resorcinols that is 5-(1-hydroxyethyl)benzene-1,3-diol in which one of the methyl hydrogens is replaced by a 1-(4-hydroxyphenyl)propan-2-amino group. A beta2-adrenergic agonist, it is used (as the hydrobromide salt) as a bronchodilator in the management of reversible airway obstruction.


name: S22A1_RAT Solute carrier family 22 member 1 (sprot)

description: A solute carrier family 22 member 1 that is encoded in the genome of rat.


cetirizine

A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.


name: MTR1A_SHEEP Melatonin receptor type 1A (sprot)


A member of the class of  tryptamines  that is melatonin with a hydroxy group substituent at position 6.


NAN 190

An N-alkylpiperazine that consists of (2-methoxyphenyl)piperazine in which the amine hydrogen is substituted by a 4-(2-phthalimido)butyl group.


name: 5HT1B_MOUSE 5-hydroxytryptamine receptor 1B (sprot)

description: A 5-hydroxytryptamine receptor 1B that is encoded in the genome of mouse.


name: 5HT1D_CANLF 5-hydroxytryptamine receptor 1D (sprot)


name: 5HT1F_HUMAN 5-hydroxytryptamine receptor 1F (sprot)

description: A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human.


name: 5HT1F_MOUSE 5-hydroxytryptamine receptor 1F (sprot)

description: A 5-hydroxytryptamine receptor 1F that is encoded in the genome of mouse.


name: 5HT1F_RAT 5-hydroxytryptamine receptor 1F (sprot)

description: A 5-hydroxytryptamine receptor 1F that is encoded in the genome of rat.


name: 5HT2B_MOUSE 5-hydroxytryptamine receptor 2B (sprot)

description: A 5-hydroxytryptamine receptor 2B that is encoded in the genome of mouse.


A member of the class of tryptamines that is tryptamine substituted by a methyl group at position 5.


name: 3-Ethyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide; hydrochloride


GR 113808

An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.


name: 5HT5B_MOUSE 5-hydroxytryptamine receptor 5B (sprot)

description: A 5-hydroxytryptamine receptor 5B that is encoded in the genome of mouse.


name: 5HT7R_MOUSE 5-hydroxytryptamine receptor 7 (sprot)

description: A 5-hydroxytryptamine receptor 7 that is encoded in the genome of mouse.


A benzodioxine that is idazoxan substituted at position 2 by a methoxy group.


An oxopurine that is xanthine in which the hydrogen attached to the nitrogen at position 7 is replaced by a methyl group. It is an intermediate metabolite in the synthesis of caffeine.


ademetionine

A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.


name: SSR3_HUMAN Somatostatin receptor type 3 (sprot)

description: A somatostatin receptor type 3 that is encoded in the genome of human.


name: SSR4_HUMAN Somatostatin receptor type 4 (sprot)

description: A somatostatin receptor type 4 that is encoded in the genome of human.


[Met]enkephalin

A peptide zwitterion obtained by transfer of a proton from the carboxy to the amino terminus of Met-enkephalin. Major species at pH 7.3.


name: 5HT6R_MOUSE 5-hydroxytryptamine receptor 6 (sprot)

description: A 5-hydroxytryptamine receptor 6 that is encoded in the genome of mouse.


name: 5HT3A_CAVPO 5-hydroxytryptamine receptor 3A (sprot)


name: GRIK4_HUMAN Glutamate receptor ionotropic, kainate 4 (sprot)

description: A glutamate receptor ionotropic, kainate 4 that is encoded in the genome of human.


A dicarboxylic acid dianion that is the conjugate base of glutamate(1-).


NAXAGOLIDE

An organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued).


name: CTDS1_HUMAN Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (sprot)

description: A carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 that is encoded in the genome of human.


name: 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)acetic acid (7-bromo-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl ester


cefalotin

A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections.


name: 3-[(4-Acetamidophenyl)sulfonylamino]propionic acid [2-[4-(2-furoyl)piperazino]-2-keto-ethyl] ester


name: 2-[(4-Acetamidophenyl)sulfonyl-methyl-amino]acetic acid [2-[4-(2-furoyl)piperazino]-2-keto-ethyl] ester


name: 1-[2-[2-[[4-(Methylthio)-3-nitro-phenyl]sulfonylamino]acetyl]oxyacetyl]isonipecotic acid methyl ester


lithocholic acid

A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.


Se-methyl-D-selenocysteine

A D-alpha-amino acid compound having methylselanylmethyl as the side-chain.


name: 3-Amino-4-chloro-benzoic acid [2-keto-2-[5-(2-keto-2-morpholino-ethyl)-2-thienyl]ethyl] ester


name: 3-(2-Methylphenoxy)propionic acid [2-[4-(2,4-dimethylphenyl)sulfonylpiperazino]-2-keto-ethyl] ester


name: (2S,3R)-3-(2-ethylhexyl)-8-methoxy-4-methylene-chroman-2-carboxylic acid ethyl ester


name: (2S,3R)-3-hexyl-8-methoxy-4-methylene-chroman-2-carboxylic acid ethyl ester


name: (4E)-4-(2-ethoxy-2-keto-ethylidene)-8-methoxy-chroman-2-carboxylic acid ethyl ester


TLR9_HUMAN Toll-like receptor 9 (sprot)

A Toll-like receptor 9 that is encoded in the genome of human.


name: Acetic acid 4-(6-nitro-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-phenyl ester


name: Acetic acid 3-(6-nitro-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-phenyl ester


BISDEMETHOXYCURCUMIN

A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.


name: Acetic acid [4-(3,4-dimethoxyphenyl)-7-keto-6-methylene-4,5-dihydrobenzothiophen-5-yl]methyl ester


brilliant green

An iminium ion that is the cationic component of the histological dye 'brilliant green'.


ethylisopropylamiloride

A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.


name: MAZF_ECOLI Endoribonuclease toxin MazF (sprot)

description: An endoribonuclease toxin MazF that is encoded in the genome of Escherichia coli K-12.


name: 5-[2-(6-hydroxy-3-methyl-2-benzofuranyl)-2-oxoethyl]-2-furancarboxylic acid ethyl ester


name: (3-Cyano-6-methyl-quinolin-2-ylsulfanyl)-acetic acid ethyl ester


name: N-[(5-morpholino-2-thienyl)methyleneamino]carbamic acid tert-butyl ester


name: Furan-2-carboxylic acid 4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenyl ester


name: 2H-1,2,4-Benzothiadiazine-3-acetic acid, 6,7-dichloro-3,4-dihydro-2-hydroxy-3-(methoxycarbonyl)-, methyl ester, 1,1-dioxide


name: APAF_HUMAN Apoptotic protease-activating factor 1 (sprot)

description: An apoptotic protease-activating factor 1 that is encoded in the genome of human.


(+)-CALANOLIDE A

An organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10R,11S,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase.


name: succinic acid O4-(2-allyl-3-cyclopropyl-6,8-diketo-7-methyl-7-isoquinolyl) ester O1-methyl ester


reumycin

A pyrimidotriazine that is 6-methyl-5,6,7,8-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 6.


SCOULERINE

A berberine alkaloid isolated from  Corydalis saxicola.


BENZETHONIUM CHLORIDE

A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses.


pyronin Y cation

An iminium ion that is the cationic component of pyronin Y.


cefixime

A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.


name: VATL2_YEAST V-type proton ATPase subunit c' (sprot)

description: A protein that is a translation product of the VMA11 gene in yeast.


name: CDR2_CANAL Multidrug resistance protein CDR2 (sprot)

description: A protein that is a translation product of the CDR2 gene in Candida albicans SC5314.


name: CDR1_CANAX Multidrug resistance protein CDR1 (sprot)


A sulfonamide in which the nitrogen is the piperidinyl nitrogen of a 2-(pyridin-3-yl)piperidin-1-yl group and the sulfonyl sulfur carries a 4-acetamidophenyl substituent.


A sulfonamide in which the nitrogen carries methyl and 2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl substituents and the sulfonyl a p-tolyl group.


name: 4-{2-[4-(Pyrrolidine-1-sulfonyl)-phenoxy]-acetylamino}-benzoic acid ethyl ester


name: 4-[3-(2-furanyl)-4-(3-nitrophenyl)-6-oxo-2,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid ethyl ester


name: 4-[[2-(6,7-dihydro-5H-cyclopenta[f]benzofuran-3-yl)acetyl]amino]benzoic acid ethyl ester


name: PAFA_MOUSE Platelet-activating factor acetylhydrolase (sprot)

description: A platelet-activating factor acetylhydrolase that is encoded in the genome of mouse.


A sulfonamide in which the nitrogen carries methyl and 2-[4-(ethoxycarbonyl)piperazin-1-yl]-2-oxoethyl substituents and the sulfonyl a 4-chlorophenyl group.


ARRB1_HUMAN Beta-arrestin-1 (sprot)

A beta-arrestin-1 that is encoded in the genome of human.


MANNOSTATIN A

An amino cyclitol that is cyclopentane substituted by hydroxy groups at positions 1, 2 and 3, by an amino group at positon 4, and by a methylsulfanediyl group at position 5 (the 1R,2R,3R,4S,5R-stereoisomer). It is isolated from the soil bacterium Streptoverticillium verticillium.


MA2A1_HUMAN Alpha-mannosidase 2 (sprot)

An alpha-mannosidase 2 that is encoded in the genome of human.


name: COMT_RAT Catechol O-methyltransferase (sprot)

description: A catechol O-methyltransferase that is encoded in the genome of rat.


name: MPIP1_HUMAN M-phase inducer phosphatase 1 (sprot)

description: An M-phase inducer phosphatase 1 that is encoded in the genome of human.


(3-aminopropyl)phosphonic acid

A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 3-aminopropyl group. It is a partial agonist of GABAB receptors.


name: FGF1_HUMAN Fibroblast growth factor 1 (sprot)

description: A fibroblast growth factor 1 that is encoded in the genome of human.


name: FGF2_HUMAN Fibroblast growth factor 2 (sprot)

description: A fibroblast growth factor 2 that is encoded in the genome of human.


name: PTN13_HUMAN Tyrosine-protein phosphatase non-receptor type 13 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 13 that is encoded in the genome of human.


MAN2_DROME Alpha-mannosidase 2 (sprot)

A protein that is a translation product of the alpha-Man-IIa gene in fruit fly.


name: SSR2_HUMAN Somatostatin receptor type 2 (sprot)

description: A somatostatin receptor type 2 that is encoded in the genome of human.


name: SSR5_HUMAN Somatostatin receptor type 5 (sprot)

description: A somatostatin receptor type 5 that is encoded in the genome of human.


name: TGT_ZYMMO Queuine tRNA-ribosyltransferase (sprot)

description: A protein that is a translation product of the tgt gene in Zymomonas mobilis subsp. mobilis ZM4.


name: CP2AD_HUMAN Cytochrome P450 2A13 (sprot)

description: A cytochrome P450 2A that is a translation product of the CYP2A13 gene in human.


GON1_RAT Progonadoliberin-1 (sprot)

A progonadoliberin-1 that is encoded in the genome of rat.


nafarelin

An oligopeptide comprising of 5-oxo-L-proline, L-histidine, L-tryptophan, L-serine, L-tyrosine, 3-(2-naphthyl)-D-alanine, L-leucine, L-arginine and L-prolylglycinamide residues joined sequence by peptide linkages. It is a gonadotropin releasing hormone agonist that is used to treat central precocious puberty in children and endometriosis in women.


nebivolol

A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a  6-fluorochroman-2-yl group.


name: AA2BR_BOVIN Adenosine receptor A2b (sprot)


name: AA2AR_CAVPO Adenosine receptor A2a (sprot)

description: An adenosine receptor A2a that is encoded in the genome of guinea pig.


fenfluramine

A  secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.


name: (6) 1H-1,2,4-triazol-3-yl-anilines 4-F3C(C6H4) 4-Pyridine


name: (9) 1H-1,2,4-triazol-3-yl-anilines 3-F3CO(C6H4) 4-Pyridine


name: (10) 1H-1,2,4-triazol-3-yl-anilines 4-F3CO(C6H4) 4-Pyridine


name: (11) 1H-1,2,4-triazol-3-yl-anilines 3-tBu-(C6H4) 4-Pyridine


name: (12) 1H-1,2,4-triazol-3-yl-anilines 4-tBu-(C6H4) 4-Pyridine


name: (13) 1H-1,2,4-triazol-3-yl-anilines 3-Cl-(C6H4) 4-Pyridine


name: (14) 1H-1,2,4-triazol-3-yl-anilines 4-Cl-(C6H4) 4-Pyridine


name: (15) 1H-1,2,4-triazol-3-yl-anilines 3-Br-(C6H4) 4-Pyridine


name: (16) 1H-1,2,4-triazol-3-yl-anilines 4-Br-(C6H4) 4-Pyridine


name: (18) 1H-1,2,4-triazol-3-yl-anilines 2-(Quinolinyl) 4-Pyridine


name: (19) 1H-1,2,4-triazol-3-yl-anilines 5-(Indazolyl) 4-Pyridine


name: (20) 1H-1,2,4-triazol-3-yl-anilines 3-F3C,4-Cl(C6H4) 4-Pyridine


name: (21) 1H-1,2,4-triazol-3-yl-anilines 3-Cl,4-F3C(C6H4) 4-Pyridine


name: (22) 1H-1,2,4-triazol-3-yl-anilines 3,4-di-Cl(C6H4) 4-Pyridine


name: (23) 1H-1,2,4-triazol-3-yl-anilines 3,4-di-MeO(C6H4) 4-Pyridine


name: (24) 1H-1,2,4-triazol-3-yl-anilines 4-Me-3-F3C(C6H3) 4-Pyridine


name: (25) 1H-1,2,4-triazol-3-yl-anilines 3-Me-4-F3C(C6H3) 4-Pyridine


name: (26) 1H-1,2,4-triazol-3-yl-anilines 2-F-4-Me(C6H3) 4-Pyridine


name: (31) 1H-1,2,4-triazol-3-yl-anilines 3-Br-(C6H4) 4-Quinolyl


name: (32) 1H-1,2,4-triazol-3-yl-anilines 3-F3C(C6H4) 4-Quinolyl


TRIDOLGOSIR

An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.


name: EP300_HUMAN Histone acetyltransferase p300 (sprot)

description: A histone acetyltransferase p300 that is encoded in the genome of human.


A phytocannabinoid that is Delta(9)-tetrahydrocannabinol in which the methyl group at C-11 has been hydroxylated . Major metabolite of Delta(9)-tetrahydrocannabinol.


name: 5HT2A_PIG 5-hydroxytryptamine receptor 2A (sprot)

description: A 5-hydroxytryptamine receptor 2A that is encoded in the genome of pig.


name: 5HT2A_MACMU 5-hydroxytryptamine receptor 2A (sprot)


name: 1,6-Dimethylergoline-8I(2)-carboxylic acid 2-hydroxy-1-methylpropyl ester


name: 6-Methylergoline-8I(2)-carboxylic acid 4-methoxycyclohexyl ester


name: NPY1R_RAT Neuropeptide Y receptor type 1 (sprot)

description: A neuropeptide Y receptor type 1 that is encoded in the genome of rat.


name: ACHA4_HUMAN Neuronal acetylcholine receptor subunit alpha-4 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human.


DL-ANABASINE

A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3.


An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2.


name: GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (sprot)

description: A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of rat.


NISCH_RAT Nischarin (sprot)

A nischarin that is encoded in the genome of rat.


name: SCNAA_RAT Sodium channel protein type 10 subunit alpha (sprot)

description: A sodium channel protein type 10 subunit alpha that is encoded in the genome of rat.


HRH2_RAT Histamine H2 receptor (sprot)

A histamine H2 receptor that is encoded in the genome of rat.


name: GBRA6_HUMAN Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of human.


NPY_RAT Pro-neuropeptide Y (sprot)

A neuropeptide Y that is encoded in the genome of rat.


NPY_HUMAN Pro-neuropeptide Y (sprot)

A neuropeptide Y that is encoded in the genome of human.


name: NPY1R_MOUSE Neuropeptide Y receptor type 1 (sprot)

description: A neuropeptide Y receptor type 1 that is encoded in the genome of mouse.


name: NPY2R_MOUSE Neuropeptide Y receptor type 2 (sprot)

description: A neuropeptide Y receptor type 2 that is encoded in the genome of mouse.


name: NPY5R_MOUSE Neuropeptide Y receptor type 5 (sprot)

description: A neuropeptide Y receptor type 5 that is encoded in the genome of mouse.


TETRAMETHYLAMMONIUM ION

The simplest quaternary ammonium cation, comprising a central nitrogen linked to four methyl groups.


name: GRM1_HUMAN Metabotropic glutamate receptor 1 (sprot)

description: A metabotropic glutamate receptor 1 that is encoded in the genome of human.


name: GRM3_HUMAN Metabotropic glutamate receptor 3 (sprot)

description: A metabotropic glutamate receptor 3 that is encoded in the genome of human.


name: GBRA4_HUMAN Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of human.


name: 9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester


name: MAL12_YEAST Alpha-glucosidase MAL12 (sprot)

description: A protein that is a translation product of the MAL12 gene in yeast.


OMBUINE

A dimethoxyflavone that is quercetin in which the hydroxy groups at positions 7 and 4' are replaced by methoxy groups. Isolated from Cyperus teneriffae, it exhibits anti-inflammatory activity.


PATULETIN

A trimethoxyflavone that is quercetagetin methylated at position 6.


ISORHAMNETIN

A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.


KAEMPFERIDE

A monomethoxyflavone that is the 4'-O-methyl derivative of kaempferol.


A dimethoxyflavone that the 3,7-di-O-methyl derivative of quercetin.


QUERCITRIN

A quercetin O-glycoside that is quercetin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.


GALLOCATECHIN

A gallocatechin  that has (2R,3S)-configuration. It is found in green tea and bananas.


diosmetin

A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities.


APIGENIN DIMETHYLETHER

A dimethoxyflavone  that is the 7,4'-dimethyl ether derivative of apigenin.


ACACETIN

A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.


ORIENTIN

A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.


VELUTIN

A dimethoxyflavone that is luteolin in which the hydroxy groups at positions 7 and 3' are replaced by methoxy groups.


HISPIDULIN

A monomethoxyflavone that is scutellarein methylated at position 6.


JACEOSIDINE

A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties.


NEVADENSIN

A trimethoxyflavone that is flavone substituted by methoxy groups at positions 6, 8 and 4' and hydroxy groups at positions 5 and 7 respectively.


hesperetin

A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.


SB 204741

A member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor.


GR 127935

A member of the class of  benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid and the anilino group of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.


name: 5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (sprot)

description: A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human.


name: 9H-pyrido[3,4-b]indole-3-carboxylic acid propyl ester


name: 5HT1D_CAVPO 5-hydroxytryptamine receptor 1D (sprot)

description: A protein that is a translation product of the HTR1D gene in guinea pig.


asenapine

An organic heterotetracyclic compound that is 2,3,3a,12b-tetrahydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole bearing methyl and chloro substituents at positions 2 and 5 respectively.


name: NPY5R_RAT Neuropeptide Y receptor type 5 (sprot)

description: A neuropeptide Y receptor type 5 that is encoded in the genome of rat.


name: NPY5R_HUMAN Neuropeptide Y receptor type 5 (sprot)

description: A neuropeptide Y receptor type 5 that is encoded in the genome of human.


name: 5HT4R_MOUSE 5-hydroxytryptamine receptor 4 (sprot)

description: A 5-hydroxytryptamine receptor 4 that is encoded in the genome of mouse.


name: MC4R_HUMAN Melanocortin receptor 4 (sprot)

description: A melanocortin receptor 4 that is encoded in the genome of human.


name: ACHA_RAT Acetylcholine receptor subunit alpha (sprot)

description: An acetylcholine receptor subunit alpha that is encoded in the genome of rat.


name: ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human.


name: GBRA3_RAT Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of rat.


midazolam

An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.


oxazepam

A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.


sertindole

A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group.


ziprasidone

A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.


astemizole

A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.


name: CLTR1_CAVPO Cysteinyl leukotriene receptor 1 (sprot)

description: A cysteinyl leukotriene receptor 1 that is encoded in the genome of guinea pig.


A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.


TKN1_HUMAN Protachykinin-1 (sprot)

A protachykinin-1 that is encoded in the genome of human.


name: HRH1_BOVIN Histamine H1 receptor (sprot)


name: SGMR1_MOUSE Sigma non-opioid intracellular receptor 1 (sprot)

description: A sigma non-opioid intracellular receptor 1 that is encoded in the genome of mouse.


(+)-ABSCISIC ACID

The naturally occurring (1'S)-(+) enantiomer of abscisic acid. It is an important sesquiterpenoid plant hormone which acts as a regulator of plant responses to environmental stresses such as drought and cold.


name: AA3R_RABIT Adenosine receptor A3 (sprot)


iloperidone

A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia.


name: GBRA4_RAT Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of rat.


name: 8-Benzyloxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester


name: 8-Azido-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester


name: GBRA6_RAT Gamma-aminobutyric acid receptor subunit alpha-6 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of rat.


P2RX4_RAT P2X purinoceptor 4 (sprot)

A P2X purinoceptor 4 that is encoded in the genome of rat.


BROMOPHENOL BLUE

3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye.


P2RX4_HUMAN P2X purinoceptor 4 (sprot)

A P2X purinoceptor 4 that is encoded in the genome of human.


An organosulfate oxoanion that is the hexanion of suramin resulting from the deprotonation of the six sulfo groups; major species at pH 7.3.


procainamide

A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group.  It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.


name: NEUT_HUMAN Neurotensin/neuromedin N (sprot)

description: A neurotensin/neuromedin N that is encoded in the genome of human.


name: EDNRA_HUMAN Endothelin-1 receptor (sprot)

description: An endothelin-1 receptor that is encoded in the genome of human.


name: EDNRB_HUMAN Endothelin receptor type B (sprot)

description: An endothelin receptor type B that is encoded in the genome of human.


NB-ACETYLTRYPTAMINE

A tryptamine compound having an acetyl substituent attached to the side-chain amino function.


name: GALR1_RAT Galanin receptor type 1 (sprot)

description: A galanin receptor type 1 that is encoded in the genome of rat.


name: GALR2_RAT Galanin receptor type 2 (sprot)

description: A galanin receptor type 2 that is encoded in the genome of rat.


A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.


name: GRM5_HUMAN Metabotropic glutamate receptor 5 (sprot)

description: A metabotropic glutamate receptor 5 that is encoded in the genome of human.


name: GRM7_HUMAN Metabotropic glutamate receptor 7 (sprot)

description: A metabotropic glutamate receptor 7 that is encoded in the genome of human.


name: GRM8_HUMAN Metabotropic glutamate receptor 8 (sprot)

description: A metabotropic glutamate receptor 8 that is encoded in the genome of human.


name: VIPR2_HUMAN Vasoactive intestinal polypeptide receptor 2 (sprot)

description: A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human.


conivaptan

The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).


vasopressin

The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.


name: V1AR_RAT Vasopressin V1a receptor (sprot)

description: A vasopressin V1a receptor that is encoded in the genome of rat.


name: V1BR_RAT Vasopressin V1b receptor (sprot)

description: A vasopressin V1b receptor that is encoded in the genome of rat.


name: (2S,8R)-3-(3,4-Dichloro-phenyl)-8-((E)-3-iodo-allyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester


name: 5HT1B_CRIGR 5-hydroxytryptamine receptor 1B (sprot)


name: 5HT4R_PIG 5-hydroxytryptamine receptor 4 (Fragment) (sprot)


name: SNAT_HUMAN Serotonin N-acetyltransferase (sprot)

description: A serotonin N-acetyltransferase that is encoded in the genome of human.


name: PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (sprot)

description: A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human.


KHSE_ECOLI Homoserine kinase (sprot)

A homoserine kinase that is encoded in the genome of Escherichia coli K-12.


name: DCTP1_HUMAN dCTP pyrophosphatase 1 (sprot)

description: A dCTP pyrophosphatase 1 that is encoded in the genome of human.


An N-alkylpiperazine that is 1-(3-chlorophenyl)piperazine carrying a 3,3-diphenyl-2-hydroxyprop-1-yl group at position 4. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.


name: HPGDS_MOUSE Hematopoietic prostaglandin D synthase (sprot)

description: A glutathione-requiring prostaglandin D synthase that is encoded in the genome of mouse.


iloprost

A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.


A beta-hydroxyketone that is 3-hydroxycyclopentanone in which a hydrogen at position 4 is replaced by a (1E)-4-hydroxy-4-methyloct-1-en-1-yl group and a hydrogen at position 5 is replaced by a 7-methoxy-7-oxoheptyl group.


name: PF2R_MOUSE Prostaglandin F2-alpha receptor (sprot)

description: A prostaglandin F2-alpha receptor that is encoded in the genome of mouse.


name: THAS_MOUSE Thromboxane-A synthase (sprot)

description: A thromboxane-A synthase that is encoded in the genome of mouse.


GALA_RAT Galanin peptides (sprot)

A galanin that is encoded in the genome of rat.


name: GBRA5_RAT Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of rat.


OPRX_MOUSE Nociceptin receptor (sprot)

A nociceptin receptor that is encoded in the genome of mouse.


desvenlafaxine

A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.


name: Galanin Message Associated Peptide (44-59) amide


name: GALR3_RAT Galanin receptor type 3 (sprot)

description: A galanin receptor type 3 that is encoded in the genome of rat.


name: ACHA4_RAT Neuronal acetylcholine receptor subunit alpha-4 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of rat.


name: ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of human.


name: ACHA3_HUMAN Neuronal acetylcholine receptor subunit alpha-3 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of human.


A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodo-4-aminobenzyl group.


2-amino-3-phosphonopropanoic acid

A non-proteinogenc alpha-amino acid that is alanine in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group.


name: GRIA3_HUMAN Glutamate receptor 3 (sprot)

description: A glutamate receptor 3 that is encoded in the genome of human.


An alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).


name: ACHA_MOUSE Acetylcholine receptor subunit alpha (sprot)

description: An acetylcholine receptor subunit alpha that is encoded in the genome of mouse.


tranylcypromine

A member of the class of cyclopropanes carrying amino and phenyl substituents at positions 1 and 2 respectively.


5NTD_RAT 5'-nucleotidase (sprot)

A 5'-nucleotidase that is encoded in the genome of rat.


ELIPRODIL

A member of the class of piperidines that is piperidine substituted by a 2-(4-chlorophenyl)-2-hydroxyethyl group at position 1 and by a 4-fluorobenzyl group at position 4.


Ro 25-6981

A member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor.


lurasidone

An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizophrenia.


name: 4-Amino-5-chloro-2-methoxy-benzoic acid 2-((3S,5R)-3,5-dimethyl-piperidin-1-yl)-ethyl ester


NAPHTHALENE

An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia.


xylazine

A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.


name: MTR1A_PIG Melatonin receptor type 1A (Fragment) (sprot)


name: MTR1B_CHICK Melatonin receptor type 1B (Fragment) (sprot)


name: MTR1C_XENLA Melatonin receptor type 1C (sprot)


name: PGH1_HUMAN Prostaglandin G/H synthase 1 (sprot)

description: A prostaglandin G/H synthase 1 that is encoded in the genome of human.


The conjugate base of diclofenac.


etodolac

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.


flurbiprofen

A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.


ibuprofen

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.


ketorolac

A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.


mefenamic acid

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.


nimesulide

An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.


A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.


piroxicam

A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.


tolmetin

A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.


VALERYL SALYCILATE

A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.


PYRC_ECOLI Dihydroorotase (sprot)

A gammaproteobacterial-type dihydroorotase that is encoded in the genome of Escherichia coli K-12.


name: DPP3_HUMAN Dipeptidyl peptidase 3 (sprot)

description: A dipeptidyl peptidase 3 (human), isoforms 1, 2, and 4.


name: MURC_ECOLI UDP-N-acetylmuramate--L-alanine ligase (sprot)

description: A UDP-N-acetylmuramate--L-alanine ligase that is encoded in the genome of Escherichia coli K-12.


name: MURE_STAA8 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase (sprot)


name: MURF_ECOLI UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (sprot)

description: A UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase that is encoded in the genome of Escherichia coli K-12.


Conjugate base of phosphinothricin arising from deprotonation of the phosphinate function.


GLNA_HUMAN Glutamine synthetase (sprot)

A glutamine synthetase that is encoded in the genome of human.


name: GFA1_CANAL Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (sprot)


name: ADA1A_CAVPO Alpha-1A adrenergic receptor (sprot)

description: An alpha-1A adrenergic receptor that is encoded in the genome of guinea pig.


reserpine

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.


A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, an allyl substituent at position 3 and two hydroxy substituents at positions 7 and 8. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.


flupentixol

A flupenthixol in which the double bond adopts a cis-configuration.


name: ACHA3_RAT Neuronal acetylcholine receptor subunit alpha-3 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of rat.


ENRASENTAN

A member of the class of indanes that is 2,3-dihydro-1H-indene which is substituted by a 1,3-benzodioxol-5-yl group, carboxy group, 2-(2-hydroxyethoxy)-4-methoxyphenyl group and a propoxy group at positions 1S, 2R, 3S and 5, respectively. It is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor. The drug was being developed by GSK for the treatment of congestive heart failure and pulmonary hypertension (clinical trials discontinued).


name: OPRK_BOVIN Kappa-type opioid receptor (sprot)


name: OPRM_MOUSE Mu-type opioid receptor (sprot)

description: A mu-type opioid receptor that is encoded in the genome of mouse.


name: PE2R3_BOVIN Prostaglandin E2 receptor EP3 subtype (sprot)


name: PF2R_BOVIN Prostaglandin F2-alpha receptor (sprot)

description: A prostaglandin F2-alpha receptor that is encoded in the genome of cow.


name: 16-phenoxy tetranor Prostaglandin F2alpha


name: GALR3_HUMAN Galanin receptor type 3 (sprot)

description: A galanin receptor type 3 that is encoded in the genome of human.


malathion

A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.


SB 224289

A member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid with the secondary amino group of 1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidine]. Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.


name: NPY2R_CAVPO Neuropeptide Y receptor type 2 (sprot)


name: NPY4R_RAT Neuropeptide Y receptor type 4 (sprot)

description: A neuropeptide Y receptor type 4 that is encoded in the genome of rat.


name: GALR1_HUMAN Galanin receptor type 1 (sprot)

description: A galanin receptor type 1 that is encoded in the genome of human.


name: V1BR_HUMAN Vasopressin V1b receptor (sprot)

description: A vasopressin V1b receptor that is encoded in the genome of human.


name: C5AR1_HUMAN C5a anaphylatoxin chemotactic receptor 1 (sprot)

description: A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human.


name: ADA1B_HUMAN Alpha-1B adrenergic receptor (sprot)

description: An alpha-1B adrenergic receptor that is encoded in the genome of human.


deoxycorticosterone

A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.


name: SGMR1_HUMAN Sigma non-opioid intracellular receptor 1 (sprot)

description: A sigma non-opioid intracellular receptor 1 that is encoded in the genome of human.


name: [hydroxy-[[3-hydroxy-5-(4-oxo-5H-imidazo[2,1-b]purin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate


name: 3-(4-Amino-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester


name: (3S,8R)-8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester


HXKA_YEAST Hexokinase-1 (sprot)

A protein that is a translation product of the HXK1 gene in yeast.


NEP_RAT Neprilysin (sprot)

A neprilysin that is encoded in the genome of rat.


name: TYTR_CRIFA Trypanothione reductase (sprot)


name: METK2_RAT S-adenosylmethionine synthase isoform type-2 (sprot)

description: A protein that is a translation product of the Mat2a gene in rat.


name: DHB3_HUMAN 17-beta-hydroxysteroid dehydrogenase type 3 (sprot)

description: A 17-beta-hydroxysteroid dehydrogenase type 3 that is encoded in the genome of human.


baicalein

A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.


An N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase that is encoded in the genome of human.


2-chlorosuccinic acid

A C4-dicarboxylic acid that is succinic acid substituted at position 2 by a chloro group.


bromosuccinic acid

A dicarboxylic acid that is succinic acid substituted at position 2 by a bromine atom.


2-methylbutanedioic acid

A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group.


cysteic acid

An amino sulfonic acid that is the sulfonic acid analogue of cysteine.


name: BRS3_HUMAN Bombesin receptor subtype-3 (sprot)

description: A bombesin receptor subtype-3 that is encoded in the genome of human.


name: GRPR_RAT Gastrin-releasing peptide receptor (sprot)

description: A gastrin-releasing peptide receptor that is encoded in the genome of rat.


name: GRPR_MOUSE Gastrin-releasing peptide receptor (sprot)

description: A gastrin-releasing peptide receptor that is encoded in the genome of mouse.


NMBR_RAT Neuromedin-B receptor (sprot)

A neuromedin-B receptor that is encoded in the genome of rat.


carprofen

Propanoic acid in which one of the methylene hydrogens is substituted by a 6-chloro-9H-carbazol-2-yl group. A non-steroidal anti-inflammatory drug, it is no longer used in human medicine but is still used for treatment of arthritis in elderly dogs.


flufenamate

A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of flufenamic acid.


meloxicam

A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.