suprofen

An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.


A member of the class of  pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor, it exhibits anticancer property.


name: PE2R2_HUMAN Prostaglandin E2 receptor EP2 subtype (sprot)

description: A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human.


name: PE2R3_RAT Prostaglandin E2 receptor EP3 subtype (sprot)

description: A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of rat.


name: PE2R2_CANLF Prostaglandin E2 receptor EP2 subtype (sprot)


name: PAR2_RAT Proteinase-activated receptor 2 (sprot)

description: A proteinase-activated receptor 2 that is encoded in the genome of rat.


name: SC6A2_BOVIN Sodium-dependent noradrenaline transporter (sprot)


name: 5-(diaminomethylideneamino)-2-[[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]amino]pentanoic acid methyl ester


A member of the class of indoles that is 6-chloro-5-fluoroindole in which the hydrogen attached to the nitrogen has been replaced by a 2-aminopropyl group.


name: NPY1R_CAVPO Neuropeptide Y receptor type 1 (sprot)


name: OPRK_MOUSE Kappa-type opioid receptor (sprot)

description: A kappa-type opioid receptor that is encoded in the genome of mouse.


name: ACE2_BOVIN Angiotensin-converting enzyme 2 (sprot)


Ile(5)-angiotensin II (1-7)

An angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro.


Val-Tyr

A dipeptide formed from L-valine and L-tyrosine residues.


name: XDH_HUMAN Xanthine dehydrogenase/oxidase (sprot)

description: A xanthine dehydrogenase/oxidase that is encoded in the genome of human.


name: 5HT1B_CAVPO 5-hydroxytryptamine receptor 1B (sprot)


name: ADA1D_HUMAN Alpha-1D adrenergic receptor (sprot)

description: An alpha-1D adrenergic receptor that is encoded in the genome of human.


LEVOFENFLURAMINE

The R-enantiomer of fenfluramine.


dexfenfluramine

The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.


name: PE2R1_HUMAN Prostaglandin E2 receptor EP1 subtype (sprot)

description: A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human.


latanoprost (isopropyl ester)

A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.


misoprostol (methyl ester)

A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.


name: PE2R3_HUMAN Prostaglandin E2 receptor EP3 subtype (sprot)

description: A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human.


name: PE2R4_HUMAN Prostaglandin E2 receptor EP4 subtype (sprot)

description: A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human.


name: PF2R_HUMAN Prostaglandin F2-alpha receptor (sprot)

description: A prostaglandin F2-alpha receptor that is encoded in the genome of human.


name: SO2A1_HUMAN Solute carrier organic anion transporter family member 2A1 (sprot)

description: A solute carrier organic anion transporter family member 2A1 that is encoded in the genome of human.


mosapride

A benzamide resulting from the formal condensation of the carboxy group of 4-amino-5-chloro-2-ethoxybenzoic acid with the amino group of 1-[4-(4-fluorobenzyl)morpholin-2-yl]methanamine.


name: CNR2_MOUSE Cannabinoid receptor 2 (sprot)

description: A cannabinoid receptor 2 that is encoded in the genome of mouse.


name: ACHA7_RAT Neuronal acetylcholine receptor subunit alpha-7 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of rat.


name: ACHA9_RAT Neuronal acetylcholine receptor subunit alpha-9 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-9 that is encoded in the genome of rat.


MOTI_HUMAN Promotilin (sprot)

A promotilin that is encoded in the genome of human.


o-tolualdehyde

A tolualdehyde compound with the methyl substituent at the 2-position.


m-tolualdehyde

A tolualdehyde compound with the methyl substituent at the 3-position.


p-tolualdehyde

A tolualdehyde compound with the methyl substituent at the 4-position.


CUMINALDEHYDE

A member of the class of  benzaldehydes that is benzaldehyde substituted by an isopropyl group at position 4. It is a component of essential oils from Cumin and exhibits insecticidal activities.


name: Tetrahydroisoquinoline hydantoin derivative, 3a


name: Tetrahydroisoquinoline hydantoin derivative, 3b


name: Tetrahydroisoquinoline hydantoin derivative, 3c


name: Tetrahydroisoquinoline hydantoin derivative, 3d


name: Tetrahydroisoquinoline hydantoin derivative, 4c


name: Tetrahydroisoquinoline hydantoin derivative, 4d


name: Tetrahydroisoquinoline hydantoin derivative, 5b


name: Tetrahydroisoquinoline hydantoin derivative, 5d


name: CNR1_TARGR Cannabinoid receptor 1 (sprot)


name: GBRA2_RAT Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of rat.


name: LT4R1_HUMAN Leukotriene B4 receptor 1 (sprot)

description: A leukotriene B4 receptor 1 that is encoded in the genome of human.


An oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds.


A HETE having a 5-hydroxy group and (6E)-, (8Z)-, (11Z)- and (14Z)-double bonds.


The 20-hydroxy derivative of leukotriene B4.


6-trans-leukotriene B4

A leukotriene that is the 6-trans-isomer of leukotriene B4.


An optically active form of 15-HETE having 15(R)-configuration.


MDMA

A member of the class of  benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.


(-)-ephedrinium

Conjugate acid of (-)-ephedrine.


name: GBRR3_HUMAN Gamma-aminobutyric acid receptor subunit rho-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit rho-3 that is encoded in the genome of human.


name: CLTR1_HUMAN Cysteinyl leukotriene receptor 1 (sprot)

description: A cysteinyl leukotriene receptor 1 that is encoded in the genome of human.


name: CLTR2_HUMAN Cysteinyl leukotriene receptor 2 (sprot)

description: A cysteinyl leukotriene receptor 2 that is encoded in the genome of human.


P2RX1_RAT P2X purinoceptor 1 (sprot)

A P2X purinoceptor 1 that is encoded in the genome of rat.


P2RX1_HUMAN P2X purinoceptor 1 (sprot)

A P2X purinoceptor 1 that is encoded in the genome of human.


P2RX3_RAT P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of rat.


name: CNR1_MOUSE Cannabinoid receptor 1 (sprot)

description: A cannabinoid receptor 1 that is encoded in the genome of mouse.


etoricoxib

A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively.


name: SO1B1_HUMAN Solute carrier organic anion transporter family member 1B1 (sprot)

description: A solute carrier organic anion transporter family member 1B1 that is encoded in the genome of human.


dysiherbaine

A furopyran that is (3aR,7aR)-hexahydro-2H-furo[3,2-b]pyran substituted by carboxy, (2S)-2-amino-2-carboxyethyl, hydroxy and methylamino groups at positions 2, 2, 6, and 7, respectively (the 2R,3aR,6S,7R,7aR-stereoisomer). A convulsant isolated from the marine sponge Dysidea herbacea that has high affinity for kainate ionotropic glutamate receptors.


(S)-ATPA

A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a 5-tert-butyl-3-hydroxy-isooxazol-4-yl group.


clemizole

A member of the class of  benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.


adenine

The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.


TYRO_HUMAN Tyrosinase (sprot)

A tyrosinase that is encoded in the genome of human.


kojic acid

A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae.


mimosine

An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.


name: CNR1_TAEGU Cannabinoid receptor 1 (sprot)


darifenacin

2-[(3S)-1-Ethylpyrrolidin-3-yl]-2,2-diphenylacetamide in which one of the hydrogens at the 2-position of the ethyl group is substituted by a  2,3-dihydro-1-benzofuran-5-yl group. It is a selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, and is used as the hydrobromide salt in the management of urinary incontinence.


name: MCHR2_HUMAN Melanin-concentrating hormone receptor 2 (sprot)

description: A melanin-concentrating hormone receptor 2 that is encoded in the genome of human.


name: AP4S1_HUMAN AP-4 complex subunit sigma-1 (sprot)

description: An AP-4 complex subunit sigma-1 that is encoded in the genome of human.


name: PTGDS_HUMAN Prostaglandin-H2 D-isomerase (sprot)

description: A prostaglandin-H2 D-isomerase that is encoded in the genome of human.


name: PTGDS_PIG Prostaglandin-H2 D-isomerase (sprot)


An organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia.


PHENYLETHYL ALCOHOL

A primary alcohol that is ethanol substituted by a phenyl group at position 2.


name: TAAR1_HUMAN Trace amine-associated receptor 1 (sprot)

description: A trace amine-associated receptor 1 that is encoded in the genome of human.


name: CALRL_PIG Calcitonin gene-related peptide type 1 receptor (sprot)


name: RAMP1_PIG Receptor activity-modifying protein 1 (sprot)


name: ADCY3_RAT Adenylate cyclase type 3 (sprot)

description: An adenylate cyclase type 3 that is encoded in the genome of rat.


name: ADA2B_MOUSE Alpha-2B adrenergic receptor (sprot)

description: An alpha-2B adrenergic receptor that is encoded in the genome of mouse.


name: CAC1B_RAT Voltage-dependent N-type calcium channel subunit alpha-1B (sprot)

description: A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of rat.


name: GBRA1_BOVIN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of cow.


name: GLRA1_RAT Glycine receptor subunit alpha-1 (sprot)

description: A glycine receptor subunit alpha-1 that is encoded in the genome of rat.


name: SHIP2_RAT Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (sprot)

description: A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 that is encoded in the genome of rat.


name: KCNJ1_RAT ATP-sensitive inward rectifier potassium channel 1 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 1 that is encoded in the genome of rat.


name: KCMB1_RAT Calcium-activated potassium channel subunit beta-1 (sprot)

description: A calcium-activated potassium channel subunit beta-1 that is encoded in the genome of rat.


name: KPCA_MOUSE Protein kinase C alpha type (sprot)

description: A protein kinase C alpha type that is encoded in the genome of mouse.


name: SCN1A_RAT Sodium channel protein type 1 subunit alpha (sprot)

description: A sodium channel protein type 1 subunit alpha that is encoded in the genome of rat.


name: SCN2A_RAT Sodium channel protein type 2 subunit alpha (sprot)

description: A sodium channel protein type 2 subunit alpha that is encoded in the genome of rat.


SMS_RAT Somatostatin (sprot)

A somatostatin that is encoded in the genome of rat.


name: NTR1_MOUSE Neurotensin receptor type 1 (sprot)

description: A neurotensin receptor type 1 that is encoded in the genome of mouse.


name: NTR2_MOUSE Neurotensin receptor type 2 (sprot)

description: A neurotensin receptor type 2 that is encoded in the genome of mouse.


tamsulosin

A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones.


fexofenadine

A piperidine-based anti-histamine compound.


hydroxyzine

A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.


name: VIP_CAVPO VIP peptides (Fragment) (sprot)


name: CRFR1_MOUSE Corticotropin-releasing factor receptor 1 (sprot)

description: A corticotropin-releasing factor receptor 1 that is encoded in the genome of mouse.


name: MCHR1_RAT Melanin-concentrating hormone receptor 1 (sprot)

description: A melanin-concentrating hormone receptor 1 that is encoded in the genome of rat.


A methyl phenyl(piperidin-2-yl)acetate that has R configuration alpha to the carbonyl group and S configuration at the stereocentre bearing the nitrogen.


dexmethylphenidate

A methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have R configuration.  It is the active enantiomer in the racemic drug methylphenidate.


BERYTHROMYCIN

An erythromycin that consists of erythronolide B having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.


A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'.


name: LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type (sprot)

description: An arachidonate 12-lipoxygenase, 12R-type that is encoded in the genome of human.


name: LOX4_SOYBN Linoleate 9S-lipoxygenase-4 (sprot)


name: 12-hydroxy-jasmonic acid 12-O-B-glucoside, 4


EPA

An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.


name: OXER1_HUMAN Oxoeicosanoid receptor 1 (sprot)

description: An oxoeicosanoid receptor 1 that is encoded in the genome of human.


docosahexaenoic acid

A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.


diroleuton

An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.


name: SC6A3_BOVIN Sodium-dependent dopamine transporter (sprot)


(R)-CITALOPRAM

A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has R-configuration at the chiral centre. It is the inactive enantiomer of citalopram.


name: VIPR1_HUMAN Vasoactive intestinal polypeptide receptor 1 (sprot)

description: A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human.


name: VIPR2_RAT Vasoactive intestinal polypeptide receptor 2 (sprot)

description: A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of rat.


name: OR8B8_MOUSE Olfactory receptor 8B8 (sprot)

description: An olfactory receptor 8B8 that is encoded in the genome of mouse.


name: GLRA1_HUMAN Glycine receptor subunit alpha-1 (sprot)

description: A glycine receptor subunit alpha-1 that is encoded in the genome of human.


name: ACHA_HUMAN Acetylcholine receptor subunit alpha (sprot)

description: An acetylcholine receptor subunit alpha that is encoded in the genome of human.


name: KCNH8_RAT Potassium voltage-gated channel subfamily H member 8 (sprot)

description: A voltage-gated potassium channel KCNH8 that is encoded in the genome of rat.


MPEP

A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.


name: DYR1A_RAT Dual specificity tyrosine-phosphorylation-regulated kinase 1A (sprot)

description: A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of rat.


NIN_HUMAN Ninein (sprot)

A ninein that is encoded in the genome of human.


name: SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (sprot)

description: A serine/threonine-protein kinase Sgk1 that is encoded in the genome of human.


name: CRFR1_MACMU Corticotropin-releasing factor receptor 1 (sprot)


name: EAA2_HUMAN Excitatory amino acid transporter 2 (sprot)

description: An excitatory amino acid transporter 2 that is encoded in the genome of human.


CANDESARTAN

A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.


name: AGTRB_RAT Type-1 angiotensin II receptor B (sprot)

description: An angiotensin II receptor 1B that is encoded in the genome of rat.


name: Carbonodithioic acid, O-(3-methylbutyl) ester, sodium salt


name: LDHA_HUMAN L-lactate dehydrogenase A chain (sprot)

description: An L-lactate dehydrogenase A chain that is encoded in the genome of human.


CARBOXYNAPHTHOL

A naphthoic acid with the carboxy group at position 2 and carrying a hydroxy substituent at the 1-position. It is a  xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms.


adenosine 5'-monophosphate(2-)

A nucleoside 5'-monophosphate(2-) that results from the removal of two protons from the phosphate group of adenosine 5'-monophosphate (AMP).


name: LDHA_RAT L-lactate dehydrogenase A chain (sprot)

description: An L-lactate dehydrogenase A chain that is encoded in the genome of rat.


name: NPFF_RAT Pro-FMRFamide-related neuropeptide FF (sprot)

description: An FMRFamide-related neuropeptide FF that is encoded in the genome of rat.


name: NPFF2_HUMAN Neuropeptide FF receptor 2 (sprot)

description: A neuropeptide FF receptor 2 that is encoded in the genome of human.


name: NPFF2_RAT Neuropeptide FF receptor 2 (sprot)

description: A neuropeptide FF receptor 2 that is encoded in the genome of rat.


name: PRLHR_HUMAN Prolactin-releasing peptide receptor (sprot)

description: A prolactin-releasing peptide receptor that is encoded in the genome of human.


SCH 23390

A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, a methyl substituent at position 3, a chloro substituent at position 7 and a hydroxy substituent at position 8.


L-cystine

The L-enantiomer of the sulfur-containing amino acid cystine.


L-homocysteic acid

A homocysteic acid with L-configuration.


name: GRM6_RAT Metabotropic glutamate receptor 6 (sprot)

description: A metabotropic glutamate receptor 6 that is encoded in the genome of rat.


name: TRHR_MOUSE Thyrotropin-releasing hormone receptor (sprot)

description: A thyrotropin-releasing hormone receptor type 1 that is encoded in the genome of mouse.


name: TRHB_XENLA Pro-thyrotropin-releasing hormone-B (sprot)


name: PDE4B_RAT 3',5'-cyclic-AMP phosphodiesterase 4B (sprot)

description: A protein that is a translation product of the Pde4b gene in rat.


name: QRFPR_HUMAN Pyroglutamylated RF-amide peptide receptor (sprot)

description: A pyroglutamylated RF-amide peptide receptor that is encoded in the genome of human.


name: NMDE2_RAT Glutamate receptor ionotropic, NMDA 2B (sprot)

description: A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of rat.


name: RXRA_RAT Retinoic acid receptor RXR-alpha (sprot)

description: A retinoic acid receptor RXR-alpha that is encoded in the genome of rat.


name: ACHA6_CHICK Neuronal acetylcholine receptor subunit alpha-6 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of chicken.


OPRX_RAT Nociceptin receptor (sprot)

A nociceptin receptor that is encoded in the genome of rat.


An oxysterol that is the 22S-hydroxy derivative of cholesterol.


A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a 3-methylphenyl substituent at position 1, an allyl substituent at position 3, a chloro substituent at position 6 and two hydroxy substituents at positions 7 and 8. High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, alpha1A and alpha1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.


A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a 3-methylphenyl substituent at position 1, a methyl substituent at position 3, a chloro substituent at position 6 and two hydroxy substituents at positions 7 and 8. Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonising the behavioral effects of cocaine.


DEALKYLATED DIETHYLPROPION

Propiophenone substituted at the beta-carbon by an amino group.


An aromatic ketone that is propiophenone in which the hydrogen alpha- to the keto group has been replaced by a methylamino group.


name: ACHA2_RAT Neuronal acetylcholine receptor subunit alpha-2 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of rat.


name: PDIA1_HUMAN Protein disulfide-isomerase (sprot)

description: A protein disulfide-isomerase that is encoded in the genome of human.


name: MK01_MOUSE Mitogen-activated protein kinase 1 (sprot)

description: A mitogen-activated protein kinase 1 that is encoded in the genome of mouse.


name: SC6A4_MOUSE Sodium-dependent serotonin transporter (sprot)

description: A sodium-dependent serotonin transporter that is encoded in the genome of mouse.


name: SC6A2_MOUSE Sodium-dependent noradrenaline transporter (sprot)

description: A sodium-dependent noradrenaline transporter that is encoded in the genome of mouse.


choline

A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.


succinylcholine

A quaternary ammonium ion that is the bis-choline ester of succinic acid.


PKD1_HUMAN Polycystin-1 (sprot)

A polycystin-1 that is encoded in the genome of human.


name: 5HT1B_CANLF 5-hydroxytryptamine receptor 1B (sprot)


name: HTR4_HALS3 Transducer protein Htr4 (sprot)


formoterol

A racemate consisting of equal amounts of arformoterol (the active enantiomer) and (S,S)-formoterol (the inactive enantiomer). Its fumaric acid salt is used as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).


name: GRIK1_HUMAN Glutamate receptor ionotropic, kainate 1 (sprot)

description: A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of human.


DHβE

An organic heterotetracyclic compound resulting from the partial hydrogenation of the 1,3-diene moiety of beta-erythroidine to give the corresponding 2-ene.


P2RX3_HUMAN P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of human.


dATP

A purine 2'-deoxyribonucleoside 5'-triphosphate having adenine as the nucleobase.


name: [[(2S,5S)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate


P2RX2_HUMAN P2X purinoceptor 2 (sprot)

A P2X purinoceptor 2 that is encoded in the genome of human.


name: GRP_HUMAN Gastrin-releasing peptide (sprot)

description: A gastrin-releasing peptide that is encoded in the genome of human.


name: NMBR_HUMAN Neuromedin-B receptor (sprot)

description: A neuromedin-B receptor that is encoded in the genome of human.


name: Q497R5_MOUSE Adenosine receptor A3 (trembl)


name: RIMB1_HUMAN Peripheral-type benzodiazepine receptor-associated protein 1 (sprot)

description: A peripheral-type benzodiazepine receptor-associated protein 1 that is encoded in the genome of human.


name: GRPR_HUMAN Gastrin-releasing peptide receptor (sprot)

description: A gastrin-releasing peptide receptor that is encoded in the genome of human.


name: CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit (sprot)

description: A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human.


name: CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human.


name: CALCA_HUMAN Calcitonin gene-related peptide 1 (sprot)


name: CLCN1_HUMAN Chloride channel protein 1 (sprot)

description: A chloride channel protein, skeletal muscle that is encoded in the genome of human.


GALA_HUMAN Galanin peptides (sprot)

A galanin that is encoded in the genome of human.


NISCH_HUMAN Nischarin (sprot)

A nischarin that is encoded in the genome of human.


name: CLTR1_MOUSE Cysteinyl leukotriene receptor 1 (sprot)

description: A cysteinyl leukotriene receptor 1 that is encoded in the genome of mouse.


name: NMDZ1_HUMAN Glutamate receptor ionotropic, NMDA 1 (sprot)

description: A glutamate receptor ionotropic, NMDA 1 that is encoded in the genome of human.


name: KCNA1_HUMAN Potassium voltage-gated channel subfamily A member 1 (sprot)

description: A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human.


name: KCMB1_HUMAN Calcium-activated potassium channel subunit beta-1 (sprot)

description: A calcium-activated potassium channel subunit beta-1 that is encoded in the genome of human.


P2RY1_HUMAN P2Y purinoceptor 1 (sprot)

A P2Y purinoceptor 1 that is encoded in the genome of human.


name: SCN1A_HUMAN Sodium channel protein type 1 subunit alpha (sprot)

description: A sodium channel protein type 1 subunit alpha that is encoded in the genome of human.


name: SCN2A_HUMAN Sodium channel protein type 2 subunit alpha (sprot)

description: A sodium channel protein type 2 subunit alpha that is encoded in the genome of human.


SMS_HUMAN Somatostatin (sprot)

A somatostatin that is encoded in the genome of human.


name: ADA17_MOUSE Disintegrin and metalloproteinase domain-containing protein 17 (sprot)

description: An ADAM 17 endopeptidase that is encoded in the genome of mouse.


UR2R_RAT Urotensin-2 receptor (sprot)

A urotensin-2 receptor that is encoded in the genome of rat.


UR2R_HUMAN Urotensin-2 receptor (sprot)

A urotensin-2 receptor that is encoded in the genome of human.


zaleplon

A pyrazolo[1,5-a]pyrimidine having a nitrile group at position 3 and a 3-(N-ethylacetamido)phenyl substituent at the 7-position.


spiramide

An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.


name: N-[(4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl)methyl]carbamic acid (phenylmethyl) ester


name: ACHA5_RAT Neuronal acetylcholine receptor subunit alpha-5 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-5 that is encoded in the genome of rat.


name: ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 (sprot)

description: A neuronal acetylcholine receptor subunit beta-4 that is encoded in the genome of human.


barasertib

A dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma.


name: PDE6C_HUMAN Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (sprot)

description: A cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' that is encoded in the genome of human.


name: PDE7A_HUMAN High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (sprot)

description: A high affinity 3',5'-cyclic-AMP phosphodiesterase 7A that is encoded in the genome of human.


name: PDE1C_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C that is encoded in the genome of human.


name: PDE2A_RAT cGMP-dependent 3',5'-cyclic phosphodiesterase (sprot)

description: A cGMP-dependent 3',5'-cyclic phosphodiesterase that is encoded in the genome of rat.


name: MRP2_HUMAN ATP-binding cassette sub-family C member 2 (sprot)

description: An ATP-binding cassette sub-family C member 2 that is encoded in the genome of human.


name: SO1B3_HUMAN Solute carrier organic anion transporter family member 1B3 (sprot)

description: A solute carrier organic anion transporter family member 1B3 that is encoded in the genome of human.


ESR1_RAT Estrogen receptor (sprot)

An estrogen receptor that is encoded in the genome of rat.


name: MCR_RAT Mineralocorticoid receptor (sprot)

description: A mineralocorticoid receptor that is encoded in the genome of rat.


name: PGRC1_RAT Membrane-associated progesterone receptor component 1 (sprot)

description: A membrane-associated progesterone receptor component 1 that is encoded in the genome of rat.


name: THA_RAT Thyroid hormone receptor alpha (sprot)

description: A protein that is a translation product of the Thra gene in rat.


fluticasone propionate

A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity.


methylphenidate

A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.


ABCBB_RAT Bile salt export pump (sprot)

A bile salt export pump that is encoded in the genome of rat.


name: EAA1_HUMAN Excitatory amino acid transporter 1 (sprot)

description: An excitatory amino acid transporter 1 that is encoded in the genome of human.


name: EAA3_HUMAN Excitatory amino acid transporter 3 (sprot)

description: An excitatory amino acid transporter 3 that is encoded in the genome of human.


name: GPCP1_RAT Glycerophosphocholine phosphodiesterase GPCPD1 (sprot)

description: A glycerophosphocholine phosphodiesterase GPCPD1 that is encoded in the genome of rat.


name: PLCD4_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 that is encoded in the genome of rat.


(R)-EDELFOSINE

A 1-octadecyl-2-methylglycero-3-phosphocholine that is the (R)-enantiomer of edelfosine.


name: PLCB1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 that is encoded in the genome of rat.


name: KAPCB_RAT cAMP-dependent protein kinase catalytic subunit beta (sprot)

description: A cAMP-dependent protein kinase catalytic subunit beta that is encoded in the genome of rat.


name: KPCA_RAT Protein kinase C alpha type (sprot)

description: A protein kinase C alpha type that is encoded in the genome of rat.


name: ROCK2_RAT Rho-associated protein kinase 2 (sprot)

description: A Rho-associated protein kinase 2 that is encoded in the genome of rat.


doxazosin

A member of the class of  quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An  antihypertensive agent, it is used in the treatment of high blood pressure.


name: RON_HUMAN Macrophage-stimulating protein receptor (sprot)

description: A macrophage-stimulating protein receptor that is encoded in the genome of human.


name: GRIA2_HUMAN Glutamate receptor 2 (sprot)

description: A glutamate receptor 2 that is encoded in the genome of human.


name: GRIA4_HUMAN Glutamate receptor 4 (sprot)

description: A glutamate receptor 4 that is encoded in the genome of human.


name: GRIK5_HUMAN Glutamate receptor ionotropic, kainate 5 (sprot)

description: A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of human.


name: GRIK3_HUMAN Glutamate receptor ionotropic, kainate 3 (sprot)

description: A glutamate receptor ionotropic, kainate 3 that is encoded in the genome of human.


name: 5HT2A_BOVIN 5-hydroxytryptamine receptor 2A (sprot)


name: ADA2B_BOVIN Alpha-2B adrenergic receptor (Fragment) (sprot)


name: AP4S1_BOVIN AP-4 complex subunit sigma-1 (sprot)


name: AP3S2_BOVIN AP-3 complex subunit sigma-2 (sprot)


A secondary amino compound that is ammonia in which nitrogen is substituted by a 1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl group and a 2-(2-ethoxyphenoxy)ethyl group.


name: Morphinan-6-ol, 4,5-epoxy-N-methyl-, (5alpha 6beta-


name: GSP1_YEAST GTP-binding nuclear protein GSP1/CNR1 (sprot)

description: A protein that is a translation product of the GSP1 gene in yeast.


name: GSP2_YEAST GTP-binding nuclear protein GSP2/CNR2 (sprot)

description: A protein that is a translation product of the GSP2 gene in yeast.


name: 6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating (sprot)

description: A 6-phosphogluconate dehydrogenase, decarboxylating that is encoded in the genome of human.


TYRO_MOUSE Tyrosinase (sprot)

A tyrosinase that is encoded in the genome of mouse.


PARAHYDROXYBENZYL ALCOHOL

A member of the class of  benzyl alcohols that is  benzyl alcohol substituted by a hydroxy group at position 4. It has been isolated from Arcangelisia gusanlung.


PLD2_HUMAN Phospholipase D2 (sprot)

A phospholipase D2 that is encoded in the genome of human.


name: VP16_HHV11 Tegument protein VP16 (sprot)

description: A protein that is a translation product of the UL48 gene in Herpes simplex virus type 1 strain 17.


name: BXA1_CLOBH Botulinum neurotoxin type A (sprot)

description: A protein that is a translation product of the botA gene in Clostridium botulinum A str. Hall.


name: BXF_CLOBO Botulinum neurotoxin type F (sprot)


name: (2,5-Dioxo-hexahydro-imidazo[4,5-d]imidazol-1-yl)-acetic acid ethyl ester


biotin

An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.


name: Benzoic acid, 3-((3-pyridinylcarbonyl)amino)-, methyl ester, N-oxide


name: 1-(3,4-Dimethylphenyl)sulfonylisonipecotic acid (5-carbomethoxy-2-furyl)methyl ester


name: 2-(2-Hydroxyethylamino)benzoic acid [2-[(2-isopropylpyrazol-3-yl)amino]-2-keto-1-methyl-ethyl] ester


name: CETP_HUMAN Cholesteryl ester transfer protein (sprot)

description: A cholesteryl ester transfer protein that is encoded in the genome of human.


name: AL5AP_HUMAN Arachidonate 5-lipoxygenase-activating protein (sprot)

description: An arachidonate 5-lipoxygenase-activating protein that is encoded in the genome of human.


name: LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (sprot)

description: A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human.


S-adenosyl-L-homocysteine

An organic sulfide that is the S-adenosyl derivative of L-homocysteine.


name: EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (sprot)

description: A histone-lysine N-methyltransferase EZH2 that is encoded in the genome of human.


IL6_HUMAN Interleukin-6 (sprot)

An interleukin-6 that is encoded in the genome of human.


name: ADHX_HUMAN Alcohol dehydrogenase class-3 (sprot)

description: An alcohol dehydrogenase class-3 that is encoded in the genome of human.


name: PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B (sprot)

description: A eukaryotic peptidyl-prolyl cis-trans isomerase B that is encoded in the genome of human.


name: PPIG_HUMAN Peptidyl-prolyl cis-trans isomerase G (sprot)

description: A peptidyl-prolyl cis-trans isomerase G that is encoded in the genome of human.


name: PPID_HUMAN Peptidyl-prolyl cis-trans isomerase D (sprot)

description: A eukaryotic-type peptidyl-prolyl cis-trans isomerase D that is encoded in the genome of human.


name: TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (sprot)

description: A tyrosyl-DNA phosphodiesterase 1 that is encoded in the genome of human.


name: NAC1_HUMAN Sodium/calcium exchanger 1 (sprot)

description: A sodium/calcium exchanger 1 that is encoded in the genome of human.


name: TAAR1_MOUSE Trace amine-associated receptor 1 (sprot)

description: A trace amine-associated receptor 1 that is encoded in the genome of mouse.


EGLN1_HUMAN Egl nine homolog 1 (sprot)

An egl nine homolog 1 that is encoded in the genome of human.


name: SC5A7_HUMAN High affinity choline transporter 1 (sprot)

description: A high affinity choline transporter 1 that is encoded in the genome of human.


SMER 28

A member of the class of quinazolines that is quinazoline which is substituted by a prop-2-en-1-ylnitrilo group and a bromo group at positions 4 and 6, respectively. It is a modulator of mammalian autophagy.


A member of the class of quinazolines that is quinazoline which is substituted by a 2-methylpiperidin-1-yl group at position 4.


name: tert-Butoxycarbonylamino-acetic acid 6-chloro-2-oxo-4-phenyl-2H-chromen-7-yl ester


cytarabine

A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties.


name: 4-(4-Morpholin-4-yl-phenylamino)-quinoline-3,6-dicarboxylic acid diethyl ester


An  aminonaphthalenesulfonic acid that is 2-naphthalenesulfonic acid substituted by an amino group at position 7 and a hydroxy group at position 4 respectively.


name: PSDE_HUMAN 26S proteasome non-ATPase regulatory subunit 14 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 14 that is encoded in the genome of human.


name: 2-[(2-ethoxy-2-oxoethyl)thio]-1-benzimidazolecarboxylic acid ethyl ester


name: {2-[(3-Amino-6-methyl-thieno[2,3-b]quinoline-2-carbonyl)-amino]-thiazol-4-yl}-acetic acid ethyl ester


An organic heteropentacyclic compound that is 3,4,5,6-tetrahydro-2H-2,6-epoxyanthra[2,3-b]oxocine-8,13-dione substituted at position 2 by a methyl group and at positions 7, 9 and 11 by hydroxy groups (the S,S-diastereomer)


name: 4-[4-(4-Hydroxy-3,5-dimethoxy-benzylidene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid methyl ester


name: Furan-2-carboxylic acid 4-(3-carboxymethyl-4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenyl ester


name: 1-[3-(4-keto-5,6,7,8-tetrahydro-3H-benzothiopheno[2,3-d]pyrimidin-2-yl)propanoyl]isonipecotic acid ethyl ester


name: PTN5_HUMAN Tyrosine-protein phosphatase non-receptor type 5 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 5 that is encoded in the genome of human.


name: 4-chlorobenzoic acid [(Z)-[amino-(4-morpholinosulfonylphenyl)methylene]amino] ester


name: 2-[2-(2-Methoxy-phenyl)-acetylamino]-4-methyl-thiazole-5-carboxylic acid ethyl ester


name: DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (sprot)

description: A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human.


name: GLI1_MOUSE Zinc finger protein GLI1 (sprot)

description: A zinc finger protein GLI1 that is encoded in the genome of mouse.


name: (2-Thiophen-2-yl-1H-indol-3-ylsulfanyl)-acetic acid ethyl ester


name: carbamimidothioic acid (5-bromo-2-propoxyphenyl)methyl ester


name: 4-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-acetylamino]-benzoic acid ethyl ester


name: 2-(1-methyl-1-pyrrolidin-1-iumyl)acetic acid cyclododecyl ester


name: 2-[1-[5-(5-Isoquinolyloxymethyl)isoxazole-3-carbonyl]-2-piperidyl]acetic acid ethyl ester


name: CRHBP_HUMAN Corticotropin-releasing factor-binding protein (sprot)

description: A corticotropin-releasing factor-binding protein that is encoded in the genome of human.


solanine

A glycoalkaloid poison found in species of the nightshade family (Solanaceae), such as the potato (Solanum tuberosum). It is a trisccharide derivative of solanidine [(22beta)-solanid-5-en-3beta-ol].


name: 2-{4-[3-(2,4-Dichloro-benzoyl)-thioureido]-phenyl}-3,3,3-trifluoro-2-hydroxy-propionic acid ethyl ester


name: 2-Cyano-4-(3-ethyl-3H-benzothiazol-2-ylidene)-3-methyl-but-2-enoic acid ethyl ester


name: 2-Acetyl-4-(3-ethyl-3H-benzothiazol-2-ylidene)-but-2-enoic acid ethyl ester


name: 4-{[2-(4-Chloro-phenyl)-thiazolidine-3-carbothioyl]-amino}-benzoic acid ethyl ester


name: 1-benzoyl-5-hydroxy-5-(4-methylphenyl)-4H-pyrazole-3-carboxylic acid ethyl ester


name: 4-oxo-2-(trifluoromethyl)-1H-thieno[3,4-b]pyridine-7-carboxylic acid methyl ester


name: ABCB6_HUMAN ATP-binding cassette sub-family B member 6 (sprot)

description: An ATP-binding cassette sub-family B member 6 that is encoded in the genome of human.


name: MSRA_BOVIN Mitochondrial peptide methionine sulfoxide reductase (sprot)


CYCLOMORUSIN

An extended flavonoid that is cyclomulberrin in which the hydroxy group at position 10 has undergone oxidative cyclisation to position 3 of the 3-methylbut-2-en-1-yl substituent, with migration of the double bond into conjugation with the aromatic ring. It is a moderate inhibitor of acetylcholinesterase (IC50 = 16.2 - 36.6 muM), and a  strong inhibitor of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) induced platelet aggregation.


name: Hexadecanoic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester


nicotine

A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.


name: ACATN_HUMAN Acetyl-coenzyme A transporter 1 (sprot)

description: An acetyl-coenzyme A transporter 1 that is encoded in the genome of human.


name: TBK1_HUMAN Serine/threonine-protein kinase TBK1 (sprot)

description: A serine/threonine-protein kinase TBK1 that is encoded in the genome of human.


name: SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (sprot)

description: A sodium channel protein type 9 subunit alpha that is encoded in the genome of human.


name: IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (sprot)

description: An isocitrate dehydrogenase [NADP] cytoplasmic that is encoded in the genome of human.


LIPG_HUMAN Endothelial lipase (sprot)

An endothelial lipase that is encoded in the genome of human.


name: TF2AA_HUMAN Transcription initiation factor IIA subunit 1 (sprot)

description: A transcription initiation factor IIA subunit 1 that is encoded in the genome of human.


name: SC5A2_MOUSE Sodium/glucose cotransporter 2 (sprot)

description: A sodium/glucose cotransporter 2 that is encoded in the genome of mouse.


name: Q9QXI6_MOUSE Sodium/glucose cotransporter 1 (trembl)


name: GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (sprot)

description: A glutaminase kidney isoform, mitochondrial that is encoded in the genome of human.


name: TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (sprot)

description: A transient receptor potential cation channel TRPV3 that is encoded in the genome of human.


name: PPGB_HUMAN Lysosomal protective protein (sprot)

description: A lysosomal protective protein that is encoded in the genome of human.


name: HISX_BRAOC Histidinol dehydrogenase, chloroplastic (sprot)


name: KCNK3_HUMAN Potassium channel subfamily K member 3 (sprot)

description: A potassium channel subfamily K member 3 that is encoded in the genome of human.


name: MECP2_HUMAN Methyl-CpG-binding protein 2 (sprot)

description: A methyl-CpG-binding protein 2 that is encoded in the genome of human.


name: M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 (sprot)

description: A mitogen-activated protein kinase kinase kinase 14 that is encoded in the genome of human.


THIOUREA

The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.


P2RX7_HUMAN P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of human.


P2RX7_RAT P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of rat.


name: ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (sprot)

description: A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human.


zileuton

A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.


name: Pyrazolyl benzenesulfonamide derivative, 7a


name: Pyrazolyl benzenesulfonamide derivative, 7b


name: Pyrazolyl benzenesulfonamide derivative, 9b


name: Pyrazolyl benzenesulfonamide derivative, 9a


N-acetyltryptophan

An N-acetylamino acid that is the N-acetyl derivative of tryptophan.


TNAA_ECOLI Tryptophanase (sprot)

A tryptophanase that is encoded in the genome of Escherichia coli K-12.


name: L-tryptophan-ethylester (p-toluene sulfuric acid salt)


name: CP26A_HUMAN Cytochrome P450 26A1 (sprot)

description: A cytochrome P450 26A1 that is encoded in the genome of human.


talarozole

A member of the class of benzothiazoles that is 2-amino-1,3-benzothiazole in which one of the amino hydrogens is replaced by a 4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl group.


name: ACHP_LYMST Acetylcholine-binding protein (sprot)


testosterone

An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..


androstenedione

A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.


A 3-oxo-Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17 and a hydroxy group at position 9.


ANDROSTENEDONE

A steroid that consists of androstane having double bonds at positions 1 and 4 and two keto groups at positions 3 and 17.


boldenone undecylenate

An  3-oxo-Delta(1),Delta(4)-steroid substituted by an oxo group at position 3 and a beta-hydroxy group at position 17. It is an  anabolic androgenic steroid that has been developed for veterinary use.


CHLE_MOUSE Cholinesterase (sprot)

A cholinesterase that is encoded in the genome of mouse.


name: S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (sprot)

description: A 3-oxo-5-alpha-steroid 4-dehydrogenase 2 that is encoded in the genome of human.


lornoxicam

A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.


tenoxicam

A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine.  Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries.


name: 1-Ethyl-4-(N''-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester


A member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively).


ponatinib

A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I).


name: HGXR_PLAFG Hypoxanthine-guanine-xanthine phosphoribosyltransferase (sprot)


name: HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase (sprot)

description: A hypoxanthine-guanine phosphoribosyltransferase that is encoded in the genome of human.


name: AMYP_PIG Pancreatic alpha-amylase (sprot)

description: A protein that is a translation product of the AMY2 gene in pig.


RECA_ECOLI Protein RecA (sprot)

A protein RecA that is encoded in the genome of Escherichia coli K-12.


carboplatin

A platinum coordination entity with cis square-planar geometry in which  platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.


B2MG_HUMAN Beta-2-microglobulin (sprot)

A beta-2-microglobulin that is encoded in the genome of human.


EPOXYAZADIRADIONE

A limonoid that is  azadiradione with an epoxy group across positions 14 and 15. Isolated from Azadirachta indica it exhibits insecticidal activitry against mosquitoes.


name: MIF_HUMAN Macrophage migration inhibitory factor (sprot)

description: A macrophage migration inhibitory factor that is encoded in the genome of human.


AZADIRADIONE

A  tetracyclic triterpenoid that is 4,4,8-trimethylandrosta-1,14-diene substituted by oxo groups at positions 3 and 16, an acetoxy group at position 7 and a furan-3-yl group at position 17. Isolated from Azadirachta indica, it exhibits antimycobacterial and anti-inflammatory activities.


salannin

A limonoid with insecticidal activity isolated from Azadirachta indica.


NIMBIN

A limonoid found in Azadirachta indica.


dimethylarsinate

The arsenic oxoanion that is the conjugate base of dimethylarsinic acid.


name: FUT7_HUMAN Alpha-(1,3)-fucosyltransferase 7 (sprot)

description: An alpha-(1,3)-fucosyltransferase 7 that is encoded in the genome of human.


gentisic acid

A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.


PROTOCATECHUIC ACID

A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.


GALLIC ACID METHYL ESTER

A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.


name: FUT6_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (sprot)

description: A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 that is encoded in the genome of human.


name: SIA4A_HUMAN CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (sprot)

description: A CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 that is encoded in the genome of human.


name: TRES_MYCTO Trehalose synthase/amylase TreS (sprot)


PERM_HUMAN Myeloperoxidase (sprot)

A myeloperoxidase that is encoded in the genome of human.


name: GLMU_ECOLI Bifunctional protein GlmU (sprot)

description: A bifunctional protein GlmU that is encoded in the genome of Escherichia coli K-12.


name: GLMU_STAAC Bifunctional protein GlmU (sprot)


name: GLMU_HAEIN Bifunctional protein GlmU (sprot)

description: A bifunctional protein GlmU that is encoded in the genome of Haemophilus influenzae Rd KW20.


name: GLMU_STRR6 Bifunctional protein GlmU (sprot)

description: A bifunctional protein GlmU that is encoded in the genome of Streptococcus pneumoniae R6.


name: UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 (sprot)

description: A ubiquitin-like modifier-activating enzyme 1 that is encoded in the genome of human.


name: PAI1_HUMAN Plasminogen activator inhibitor 1 (sprot)

description: A plasminogen activator inhibitor 1 that is encoded in the genome of human.


QUINALIZARIN

A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions.


Sennoside A

A member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S.


name: UROK_MOUSE Urokinase-type plasminogen activator (sprot)

description: A urokinase-type plasminogen activator that is encoded in the genome of mouse.


name: MMP25_HUMAN Matrix metalloproteinase-25 (sprot)

description: A matrix metalloproteinase-25 that is encoded in the genome of human.


name: CarbaMic acid, N-ethyl-, (1R,2R,5R,6S)-6-[[[4-(diMethylaMino)phenyl]aMino]carbonyl]-8-(phenylMethyl)-8-azabicyclo[3.2.1]oct-2-yl ester


A tricarboxylic acid trianion, obtained by deprotonation of the three carboxy groups of citric acid.


name: NAHY_PSEPU Methyl-accepting chemotaxis protein NahY (sprot)


oxalacetic acid

An oxodicarboxylic acid that is succinic acid bearing a single oxo group.


malic acid

A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.


butyric acid

A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.


ISOCITRATE

A tricarboxylic acid that is propan-1-ol with a hydrogen at each of the 3 carbon positions replaced by a carboxy group.


CP2E1_HUMAN Cytochrome P450 2E1 (sprot)

A cytochrome P450 2E1 that is encoded in the genome of human.


phosphoramidon

A dipeptide isolated from the cultures of Streptomyces tanashiensis.


name: EFCE2_HUMAN EEF1AKMT4-ECE2 readthrough transcript protein (sprot)

description: An EEF1AKMT4-ECE2 readthrough transcript protein that is encoded in the genome of human.


name: CP125_MYCTO Steroid C26-monooxygenase (sprot)


name: CP142_MYCTO Steroid C26-monooxygenase (sprot)


voriconazole

A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.


itraconazole

An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.


4-CHOLESTEN 3-ONE

A cholestanoid that is cholest-4-ene substituted by an oxo group at position 3.


cholesterol

A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.


name: MK13_HUMAN Mitogen-activated protein kinase 13 (sprot)

description: A mitogen-activated protein kinase 13 that is encoded in the genome of human.


name: DNPH1_RAT 5-hydroxymethyl-dUMP N-hydrolase (sprot)

description: A 5-hydroxymethyl-dUMP N-hydrolase that is encoded in the genome of rat.


neostigmine

A  quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.


ANILINE

A primary arylamine in which an amino functional group is substituted for one of the benzene hydrogens.


BENZYLAMINE

A primary amine compound having benzyl as the N-substituent. It has been isolated from  Moringa oleifera (horseradish tree).


CP130_MYCTU Cytochrome P450 130 (sprot)

A protein that is a translation product of the cyp130 gene in Mycobacterium tuberculosis H37Rv.


name: TRYS_TRYCC Trypanothione synthetase (sprot)


DOG

1,2-diacyl-sn-glycerol in which both the 1- and 2-acyl groups are specified as octanoyl. Formula C19H36O5.


name: NADE_HUMAN Glutamine-dependent NAD(+) synthetase (sprot)

description: A glutamine-dependent NAD(+) synthetase that is encoded in the genome of human.


A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4.


name: SDF1_HUMAN Stromal cell-derived factor 1 (sprot)

description: A stromal cell-derived factor 1 that is encoded in the genome of human.


A member of the class of chalcones that is trans-chalcone hydroxylated at C-2' and C-4.


name: LCAT_HUMAN Phosphatidylcholine-sterol acyltransferase (sprot)

description: A phosphatidylcholine-sterol acyltransferase that is encoded in the genome of human.


name: DOT1L_HUMAN Histone-lysine N-methyltransferase, H3 lysine-79 specific (sprot)

description: A histone-lysine N-methyltransferase, H3 lysine-79 specific that is encoded in the genome of human.


A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.


name: CK2N2_BOVIN Calcium/calmodulin-dependent protein kinase II inhibitor 2 (sprot)


orciprenaline

A racemate composed of equimolar amounts of (R)- and (S)-orciprenaline. Used (as its sulfate salt) to relax the airway muscles and improve breathing for patients suffering from asthma or bronchitis.


A monocarboxylic acid anion that is the conjugate base of 3-indoleacrylic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


TRPR_ECOLI Trp operon repressor (sprot)

A trp operon repressor that is encoded in the genome of Escherichia coli K-12.


An  indol-3-yl carboxylic acid anion that is the conjugate base of  indole-3-butyric acid, arising from the deprotonation of the carboxy group.


A monocarboxylic acid anion that is the conjugate base of 3-(1H-indol-3-yl)propanoic acid.


tryptophan zwitterion

An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of tryptophan; major species at pH 7.3.


TRYPTOPHOL

An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2.


A 2-hydroxy carboxylate that is the conjugate base of 3-(indol-3-yl)lactic acid.


tryptaminium

An  ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3.


An indol-3-yl carboxylic acid anion that is the conjugate base of indole-3-acetic acid.


name: AHR_MOUSE Aryl hydrocarbon receptor (sprot)

description: An aryl hydrocarbon receptor that is encoded in the genome of mouse.


name: P4HA1_CHICK Prolyl 4-hydroxylase subunit alpha-1 (sprot)


2,3-DIHYDROXYBENZOIC ACID

A dihydroxybenzoic acid that is  benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.


2,6-dihydroxybenzoic acid

A dihydroxybenzoic acid having the two hydroxy groups at the C-2 and C-6 positions.


3,5-dihydroxybenzoic acid

A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 5.


PYROGALLOL

A  benzenetriol carrying hydroxy groups at positions 1, 2 and 3.


3,4-dihydroxymandelic acid

A catechol that is the 3,4-dihydroxy derivative of mandelic acid; a metabolite of L-dopa.


DIHYDROCAFFEIC ACID

A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. Also known as dihydrocaffeic acid, it is a metabolite of caffeic acid and exhibits antioxidant activity.


name: LYPA1_HUMAN Acyl-protein thioesterase 1 (sprot)

description: An acyl-protein thioesterase 1 that is encoded in the genome of human.


3-acetylphenylboronic acid

A member of the class of boronic acids that is  phenylboronic acid substituted by an acetyl group at position 3.


name: LYPA2_HUMAN Acyl-protein thioesterase 2 (sprot)

description: An acyl-protein thioesterase 2 that is encoded in the genome of human.


edrophonium

A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.


name: acetic acid [4-[(4-hydroxyanilino)-oxomethyl]-2-methoxyphenyl] ester


PENTACHLOROPHENOL

A  chlorophenol that is phenol substituted by 5 chloro groups.


name: PCPB_SPHCR Pentachlorophenol 4-monooxygenase (sprot)


The 2,3,5,6-isomer of tetrachlorophenol


TETRACHLOROHYDROQUINONE

A tetrachlorobenzene that is 1,2,4,5-tetrachlorobenzene in which the hydrogens at positions 3 and 6 are replaced by hydroxy groups.


A trichlorophenol with phenolic substituents on positions 2, 4 and 6.


A dichlorophenol with the chloro substituents at positions 2 and 6.


name: CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)

description: A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of human.


name: CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (sprot)

description: A 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial that is encoded in the genome of human.


name: DCMS_AFIC5 Carbon monoxide dehydrogenase small chain (sprot)


name: KDM5A_HUMAN Lysine-specific demethylase 5A (sprot)

description: A lysine-specific demethylase 5A that is encoded in the genome of human.


NICOTINALDEHYDE

A pyridinecarbaldehyde that is pyridine substituted by a formyl group at position 3.


PNC1_YEAST Nicotinamidase (sprot)

A nicotinamidase that is encoded in the genome of yeast.


A nitrile that is  pyridine substituted by a cyano group at position 3.


dactolisib

An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.


name: KDM1A_HUMAN Lysine-specific histone demethylase 1A (sprot)

description: A lysine-specific histone demethylase 1A that is encoded in the genome of human.


name: DLDH_MYCTO Dihydrolipoyl dehydrogenase (sprot)


name: DDAH1_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (sprot)

description: An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human.


L-citrulline

The L-enantiomer of citrulline.


NG,NG-dimethyl-L-arginine

A L-arginine derivative  having two methyl groups both attached to the primary amino moiety of the guanidino group.


THIOCITRULLINE

An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group.


name: PARN_HUMAN Poly(A)-specific ribonuclease PARN (sprot)

description: A poly(A)-specific ribonuclease PARN that is encoded in the genome of human.


name: PPIL1_HUMAN Peptidyl-prolyl cis-trans isomerase-like 1 (sprot)

description: A peptidyl-prolyl cis-trans isomerase-like 1 that is encoded in the genome of human.


name: LPXC_ECOLI UDP-3-O-acyl-N-acetylglucosamine deacetylase (sprot)

description: A UDP-3-O-acyl-N-acetylglucosamine deacetylase that is encoded in the genome of Escherichia coli K-12.


name: NU1M_BOVIN NADH-ubiquinone oxidoreductase chain 1 (sprot)


thiamine

A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.


name: THIB_ECOLI Thiamine-binding periplasmic protein (sprot)

description: A thiamine-binding periplasmic protein that is encoded in the genome of Escherichia coli K-12.


thiamine monophosphate

A thiamine phosphate that is thiamin(1+) in which the hydroxy group is replaced by a phosphate group.


COCARBOXYLASE

A thiamine phosphate that is thiamine(1+) in which the hydroxy group has been replaced by a diphosphate group. It is the active form of vitamin B1 and an essential cofactor for enzymes in key metabolic pathways.


oxalate

A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of oxalic acid.


name: OADC_PSEAE Oxaloacetate decarboxylase (sprot)


A triply-charged monocarboxylic acid anion obtained by deprotonation of the carboxy and phospho groups of 3-phosphonopyruvic acid.


A 2-oxo monocarboxylic acid anion that is the conjugate base of 2-oxopentanoic acid, obtained by deprotonation of the carboxy group.


pyruvate

A 2-oxo monocarboxylic acid anion that is the conjugate base of pyruvic acid, arising from deprotonation of the carboxy group.


name: AK1H_ECOLI Bifunctional aspartokinase/homoserine dehydrogenase 1 (sprot)

description: A bifunctional aspartokinase/homoserine dehydrogenase 1 that is encoded in the genome of Escherichia coli K-12.


L-2,4-diaminobutyric acid

A 2,4-diaminobutyric acid that has S-configuration.


An L-alpha-amino acid anion that is the  conjugate base of L-norleucine.


L-valinate

The L-enantiomer of valinate.


isoglutamic acid

A 1,5-dicarboxylic acid compound having a 3-amino substituent. It has been isolated from the extracts of the algae, Chondria armata.


L-alaninate

The L-enantiomer of alaninate.


An O-phosphonatooxyserine(2-) that is the conjugate base of O-phospho-L-serine.


name: CARA_ECOLI Carbamoyl phosphate synthase small chain (sprot)

description: A carbamoyl phosphate synthase small chain that is encoded in the genome of Escherichia coli K-12.


An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group


indole-3-carboxylic acid

An indole-3-carboxylic acid carrying a carboxy group at position 3.


GYRA_MYCTU DNA gyrase subunit A (sprot)

A DNA gyrase subunit A that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: RADA_PYRFU DNA repair and recombination protein RadA (sprot)


A naphthol carrying a hydroxy group at position 1.


betanaphthol

A naphthol carrying a hydroxy group at position 2.


name: KASA_MYCTU 3-oxoacyl-[acyl-carrier-protein] synthase 1 (sprot)

description: A 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: KASA_MYCTO 3-oxoacyl-[acyl-carrier-protein] synthase 1 (sprot)


name: TRPD_MYCTO Anthranilate phosphoribosyltransferase (sprot)


salicylates

Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.


guanidinoacetate

A monocarboxylic acid anion that is the conjugate base of guanidinoacetic acid, obtained by deprotonation of the carboxy group.


aminoguanidine

A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.


CP1A1_HUMAN Cytochrome P450 1A1 (sprot)

A cytochrome P450 1A1 that is encoded in the genome of human.


name: AROB_ECOLI 3-dehydroquinate synthase (sprot)

description: A 3-dehydroquinate synthase that is encoded in the genome of Escherichia coli K-12.


name: STK10_HUMAN Serine/threonine-protein kinase 10 (sprot)

description: A serine/threonine-protein kinase 10 that is encoded in the genome of human.


wedelolactone

A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.


UMBELLIFERONE

A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.


name: M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (sprot)

description: A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human.


name: A4_HUMAN Amyloid-beta precursor protein (sprot)

description: An amyloid-beta precursor protein that is encoded in the genome of human.


An  aralkylamino compound that is benzylamine substituted by a methoxy group at the para position.


METHYLAMINE

The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent.


name: EGLN2_HUMAN Prolyl hydroxylase EGLN2 (sprot)

description: A prolyl hydroxylase EGLN2 that is encoded in the genome of human.


name: EGLN3_HUMAN Prolyl hydroxylase EGLN3 (sprot)

description: A prolyl hydroxylase EGLN3 that is encoded in the genome of human.


ethyl violet cation

An iminium ion that is the cationic component of the histological dye 'ethyl violet'.


name: (6aR,11aS)-6-cyclohexyl-3,9-dimethoxy-5-oxo-6a,11-dihydroindeno[1,2-c]isoquinoline-11a-carboxylic acid ethyl ester


name: (6aR,11aS)-6-cyclohexyl-8,9,10-trimethoxy-5-oxo-6a,11-dihydroindeno[1,2-c]isoquinoline-11a-carboxylic acid ethyl ester


name: Thiophene-2-carboxylic acid [2-isobutyl-6,8-diketo-3-(4-keto-4-methoxy-butyl)-7-methyl-7-isoquinolyl] ester


name: 2-Thiophenecarboxylic acid [2-cyclopentyl-3-(4-methoxy-4-oxobutyl)-7-methyl-6,8-dioxo-7-isoquinolinyl] ester


name: 3a,8b-dihydroxy-4-keto-2-methyl-1H-indeno[1,2-b]pyrrole-3-carboxylic acid butyl ester


name: 2-Thiophenecarboxylic acid [3-(4-methoxy-4-oxobutyl)-7-methyl-6,8-dioxo-2-[2-(2-pyridinyl)ethyl]-7-isoquinolinyl] ester


name: 5-amino-3-(2-methylphenyl)-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid ethyl ester


name: 2-Thiophenecarboxylic acid [2-cyclopropyl-3-(4-methoxy-4-oxobutyl)-7-methyl-6,8-dioxo-7-isoquinolinyl] ester


name: 2-quinoxalinecarboxylic acid [2-cyclopropyl-3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-7-isoquinolinyl] ester


primaquine

An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.


alosetron

A pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position.


name: Benzoic acid, 2-[1,3,4',5'-tetrahydro-1-oxospiro[2H-inden-2,3'-[3H]pyrazol]-4'-yl]-4-methyl-, methyl ester


name: 2-quinoxalinecarboxylic acid [2-(2-methoxyethyl)-3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-7-isoquinolinyl] ester


name: benzenesulfonic acid [4-[bis(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-2-methoxyphenyl] ester


name: benzenesulfonic acid [4-[bis(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-2-ethoxyphenyl] ester


name: 4-methylbenzenesulfonic acid [4-[bis(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-2-methoxyphenyl] ester


name: Cyclopentanecarboxylic acid [2-cyclohexyl-3-(4-methoxy-4-oxobutyl)-7-methyl-6,8-dioxo-5-phenyl-7-isoquinolinyl] ester


eseroline

A pyrroloindole that is 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole substituted by methyl groups at positions 1, 3a and 8 and a hydroxy group at position 5. It is a metabolite of physostigmine and causes neuronal cell death by a mechanism involving loss of cell ATP.


name: 2-quinoxalinecarboxylic acid [3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-2-(phenylmethyl)-7-isoquinolinyl] ester


name: 5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] ester


SKN1_CAEEL Protein skinhead-1 (sprot)

A protein that is a translation product of the skn-1 gene in worm.


PARAROSANILINE

An imine that is 4-methylidenecyclohexa-2,5-dien-1-imine in which both the hydrogens of the methylidene group are replaced by 4-aminophenyl groups. The hydrochloride salt is the histological dye 'pararosaniline'.


WNT3A_MOUSE Protein Wnt-3a (sprot)

A protein Wnt-3a that is encoded in the genome of mouse.


name: 3-Methyl-1-adamantanecarboxylic acid 2-[4-methyl-3-(phenylmethyl)-5-thiazol-3-iumyl]ethyl ester;chloride


name: HSP12_CAEEL Heat shock protein hsp-16.2 (sprot)

description: A protein that is a translation product of the hsp-16.2 gene in worm.


name: EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (sprot)

description: An endothelial PAS domain-containing protein 1 that is encoded in the genome of human.


name: {2-[3-(2-Methyl-benzoyl)-thioureido]-thiazol-4-yl}-acetic acid ethyl ester


name: 2-[2-[(2E)-2-[[4-(trifluoromethyl)phenyl]methylidene]hydrazinyl]-4-thiazolyl]acetic acid ethyl ester


name: 2-[2-[[benzamido(sulfanylidene)methyl]amino]-4-thiazolyl]acetic acid ethyl ester


name: 3-[[oxo-[3-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]methoxy]methyl]benzoic acid ethyl ester


name: 3-(3-Benzo[1,3]dioxol-5-yl-acryloylamino)-benzoic acid ethyl ester


name: 2,5-dimethoxybenzenesulfonic acid (1,3-dioxo-2-isoindolyl) ester


name: (Z)-2-(5-methyl-1-tetrazolyl)-3-phenyl-2-propenoic acid [2-(4-chloro-2-fluoroanilino)-2-oxoethyl] ester


name: (Z)-2-(5-methyl-1-tetrazolyl)-3-phenyl-2-propenoic acid [2-[3-(dimethylsulfamoyl)anilino]-2-oxoethyl] ester


name: CXCR5_HUMAN C-X-C chemokine receptor type 5 (sprot)

description: A C-X-C chemokine receptor type 5 that is encoded in the genome of human.


name: 3-amino-4-[(4-chlorophenyl)thio]benzoic acid methyl ester


name: 2-(2-Hydroxyethylamino)-5-nitrobenzoic acid [2-[2-(2-methylanilino)-2-oxoethyl]-4-thiazolyl]methyl ester


NRP1_HUMAN Neuropilin-1 (sprot)

A neuropilin-1 that is encoded in the genome of human.


name: Acetic acid 4-(acetyl-benzenesulfonyl-amino)-2-bromo-naphthalen-1-yl ester


ketotifen

An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.


clemastine

2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.


alverine

A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel syndrome.


citric acid

A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.


name: LARG1_HUMAN Xylosyl- and glucuronyltransferase LARGE1 (sprot)

description: A xylosyl- and glucuronyltransferase LARGE1 that is encoded in the genome of human.


name: ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (sprot)

description: An Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 that is encoded in the genome of human.


name: Furan-2-carboxylic acid 4-(3-carboxymethyl-4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-phenyl ester


A lignan that is (+)-lyoniresinol substituted by a beta-D-glucopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from the root barks of Stemmadenia minima and Lycium chinense, it exhibits antimicrobial activities.


name: PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (sprot)

description: A low molecular weight phosphotyrosine protein phosphatase that is encoded in the genome of human.


erythromycin

An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.


name: 4-(dimethylsulfamoyl)benzoic acid [2-oxo-2-(3-oxo-4H-1,4-benzoxazin-6-yl)ethyl] ester


name: 3-fluorobenzoic acid [4-[(E)-(nicotinoylhydrazono)methyl]phenyl] ester


name: Thiophene-2-carboxylic acid 4-[(4-chloro-benzoyl)-hydrazonomethyl]-phenyl ester


name: NADD_STAAN Probable nicotinate-nucleotide adenylyltransferase (sprot)


name: (4Z)-4-piperonylidene-2,3-dihydro-1H-acridine-9-carboxylic acid [2-keto-2-(4-sulfamoylanilino)ethyl] ester


name: (2S)-2-(5,5-diketo-9,11-dimethoxy-7H-benzo[d][1,2]benzothiazepin-6-yl)-4-methyl-valeric acid methyl ester


name: HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (sprot)

description: A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human.


name: CCR5_HUMAN C-C chemokine receptor type 5 (sprot)

description: A C-C chemokine receptor type 5 that is encoded in the genome of human.


name: ARFG1_RAT ADP-ribosylation factor GTPase-activating protein 1 (sprot)

description: An ADP-ribosylation factor GTPase-activating protein 1 that is encoded in the genome of rat.


name: 3-(2-Pyridin-3-yl-quinazolin-4-ylamino)-benzoic acid methyl ester


name: 5-Methoxy-3-methyl-2-benzofurancarboxylic acid [2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl] ester


name: 5-Ethoxy-3-methyl-2-benzofurancarboxylic acid [2-(3-methyl-1-piperidinyl)-2-oxoethyl] ester


name: ENV_HV1H2 Envelope glycoprotein gp160 (sprot)

description: An HIV env gene translation product that is encoded in the genome of human immunodeficiency virus type 1 group M subtype B (isolate HXB2).


name: N-(5-benzoyl-4-phenyl-2-thiazolyl)carbamic acid methyl ester


name: Carbonic acid 6-oxo-6H-benzo[c]chromen-3-yl ester phenyl ester


name: Fumagillin from Aspergillus fumigatus, >=90%, powder


name: 2,4-Dihydroxybenzoic acid [2-[4-[2-(2,4-dihydroxybenzoyl)oxyacetyl]piperazino]-2-keto-ethyl] ester


name: 3-(1,3-Dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)propanoic acid [2-[2-(4-fluorophenyl)ethylamino]-2-oxoethyl] ester


name: TR10B_HUMAN Tumor necrosis factor receptor superfamily member 10B (sprot)

description: A tumor necrosis factor receptor superfamily member 10B that is encoded in the genome of human.


name: ALF_MYCTU Fructose-bisphosphate aldolase (sprot)

description: A fructose-bisphosphate aldolase class 2 that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: 1-butyl-2,4-dioxo-7-thiophen-2-yl-5-pyrido[2,3-d]pyrimidinecarboxylic acid ethyl ester


name: N-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]carbamic acid methyl ester


name: 1-[(4-fluorophenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester


name: 7-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)-1-oxoethyl]amino]-5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid ethyl ester


sulfamethizole

A sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2.


stavudine

A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase


sulfachlorpyridazine

A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.


erythromycin ethyl succinate

A erythromycin derivative that is erythromycin A in which the hydroxy group at position 3R is substituted by a (4-ethoxy-4-oxobutanoyl)oxy group. It is used for the treatment of a wide variety of bacterial infections.


sulfathiazole

A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.


A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 5.


name: TVA4_HUMAN T cell receptor alpha variable 4 (sprot)

description: A protein that is a translation product of the TRAV4 gene in human.


name: 4-[(3,4-dichlorophenyl)carbamoylamino]-2-ethyl-1H-1,5-benzodiazepine-3-carboxylic acid ethyl ester


ALBU_BOVIN Albumin (sprot)

An albumin that is encoded in the genome of cow.


A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.


A cephalosporin carboxylic acid anion having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups, formed by proton loss from the carboxy group of the cephalosporin cefotaxime.


name: GNA15_HUMAN Guanine nucleotide-binding protein subunit alpha-15 (sprot)

description: A guanine nucleotide-binding protein subunit alpha-15 that is encoded in the genome of human.


name: 4-Keto-4-(phenethylamino)butyric acid propargyl ester


betahistine

An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.


name: 2-Acetylamino-3,3,3-trifluoro-2-phenethylamino-propionic acid ethyl ester


name: 3,3,3-Trifluoro-2-phenethylamino-2-propionylamino-propionic acid ethyl ester


name: 4-[5-(2-phenylethyl)-2-sulfanylidene-1,3,5-triazinan-1-yl]benzoic acid ethyl ester


A monomethoxybenzene that is dopamine in which the hydroxy group at position 3 is replaced by a methoxy group. It is a metabolite of the neurotransmitter dopamine and considered a potential biomarker of pheochromocytomas and paragangliomas.


name: N-[(1S)-2-[(2S)-2-[2-(2-chlorophenyl)ethylcarbamoyl]pyrrolidino]-2-keto-1-(3-pyridylmethyl)ethyl]carbamic acid ethyl ester;2,2,2-trifluoroacetic acid


name: N-[(1S)-2-[(2S)-2-[2-(2-chlorophenyl)ethylcarbamoyl]pyrrolidino]-2-keto-1-phenyl-ethyl]carbamic acid ethyl ester


name: N-[(1S)-2-[(2S)-2-[2-(2-chlorophenyl)ethylcarbamoyl]pyrrolidino]-1-cyclohexyl-2-keto-ethyl]carbamic acid ethyl ester


name: 5-Methoxy-3-methyl-2-benzofurancarboxylic acid [2-[(2-methoxyphenyl)methylamino]-2-oxoethyl] ester


name: SMCA2_HUMAN Probable global transcription activator SNF2L2 (sprot)

description: A probable global transcription activator SNF2L2 that is encoded in the genome of human.


name: 4-(4-acetylphenoxy)butanoic acid [5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl ester


name: N-(4-phenylmethoxyphenyl)carbamic acid methyl ester


name: 2-[2-nitro-4-(trifluoromethyl)phenyl]sulfinylacetic acid (4-chlorophenyl) ester


A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of (3R,5S)-fluvastatin.


difenpiramide

A monocarboxylic acid amide obtained by formal condensation of the carboxy group from biphenyl-4-ylacetic acid with the amino group of 2-aminopyridine. Used for treatment of rheumatoid arthritis.


An acridinium ion resulting from the protonation of the ring nitrogen of 9-aminoacridine. The major species at pH 7.3.


name: 3,4,5,6-Tetrachloropicolinic acid [2-keto-2-(m-anisylamino)ethyl] ester


TOYOCAMYCIN

An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.


ISOLIQUIRITIGENIN

A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.


name: 2-[(4S,5R)-5-(2-bromophenyl)-4-methyl-4,5,7,8-tetrahydrotriazolo[1,5-d][1,4]oxazepin-3-yl]acetic acid methyl ester


name: 4-Amino-3-cyclohexylcarbamoyl-isothiazole-5-carboxylic acid tert-butylcarbamoyl-methyl ester


name: 1-[5-(5-Isoquinolyloxymethyl)isoxazole-3-carbonyl]pipecolinic acid methyl ester


SANGIVAMYCIN

A nucleoside analogue that is adenosine in which the nitrogen at position 7 is replaced by a carbamoyl-substituted carbon. It is a potent inhibitor of protein kinase C.


name: NR0B1_HUMAN Nuclear receptor subfamily 0 group B member 1 (sprot)

description: A nuclear receptor subfamily 0 group B member 1 that is encoded in the genome of human.


forskolin

A labdane diterpenoid isolated from the Indian Coleus plant.


BREFELDIN A

A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.


CENTAUREIDIN

A trihydroxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii and Athroisma proteiforme.


name: ECE1_RAT Endothelin-converting enzyme 1 (sprot)

description: An endothelin-converting enzyme 1 that is encoded in the genome of rat.


name: ATR_HUMAN Serine/threonine-protein kinase ATR (sprot)

description: A serine/threonine-protein kinase ATR that is encoded in the genome of human.


name: OX2R_HUMAN Orexin receptor type 2 (sprot)

description: An orexin receptor type 2 that is encoded in the genome of human.


OX2R_RAT Orexin receptor type 2 (sprot)

An orexin receptor type 2 that is encoded in the genome of rat.


name: OX1R_RAT Orexin/Hypocretin receptor type 1 (sprot)

description: An orexin/hypocretin receptor type 1 that is encoded in the genome of rat.


name: CCRL2_HUMAN C-C chemokine receptor-like 2 (sprot)

description: A C-C chemokine receptor-like 2 that is encoded in the genome of human.


TKNK_HUMAN Tachykinin-3 (sprot)

A tachykinin-3 that is encoded in the genome of human.


name: ACACA_HUMAN Acetyl-CoA carboxylase 1 (sprot)

description: An acetyl-CoA carboxylase 1 that is encoded in the genome of human.


name: ACACA_RAT Acetyl-CoA carboxylase 1 (sprot)

description: An acetyl-CoA carboxylase 1 that is encoded in the genome of rat.


name: SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (sprot)

description: A sodium- and chloride-dependent glycine transporter 1 that is encoded in the genome of human.


name: S22AC_HUMAN Solute carrier family 22 member 12 (sprot)

description: A solute carrier family 22 member 12 that is encoded in the genome of human.


A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione substituted by (2R)-2,3-dihydroxypropyl, (2-fluoro-4-iodophenyl)amino, fluoro, and methyl groups at positions 3, 5, 6, and 8, respectively. It is a non-ATP competitive allosteric inhibitor of MEK1/2.


name: HDAC1_MOUSE Histone deacetylase 1 (sprot)

description: A histone deacetylase 1 that is encoded in the genome of mouse.


name: CSF1_MOUSE Macrophage colony-stimulating factor 1 (sprot)

description: A macrophage colony-stimulating factor 1 that is encoded in the genome of mouse.


name: Acetic acid 4-chloro-3-{5-methyl-3-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-benzo[1,2,4]triazin-7-yl}-phenyl ester


name: [(2-Cyclopentylamino-acetylamino)-phenyl-methyl]-phosphonic acid diphenyl ester


name: NADE_BACAN NH(3)-dependent NAD(+) synthetase (sprot)


name: trans-{4-[8-Amino-1-(4-phenoxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexylmethyl}-carbamic acid benzyl ester


name: 4-(8-Amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester


name: trans-4-[8-Amino-1-(4-phenoxyphenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid methyl ester


name: trans-{4-[4-Amino-5-(4-phenoxy-phenyl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexylmethyl}-carbamic acid benzyl ester


name: trans-4-[4-Amino-5-(4-phenoxy-phenyl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid methyl ester


name: UPAR_RAT Urokinase plasminogen activator surface receptor (sprot)

description: A urokinase plasminogen activator surface receptor that is encoded in the genome of rat.


PLMN_RAT Plasminogen (sprot)

A plasminogen that is encoded in the genome of rat.


THRB_RAT Prothrombin (sprot)

A prothrombin that is encoded in the genome of rat.


TRY1_RAT Serine protease 1 (sprot)

A trypsin-2 that is encoded in the genome of rat.


name: CSF1R_MOUSE Macrophage colony-stimulating factor 1 receptor (sprot)

description: A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of mouse.


name: Propyl-carbamic acid (6R,7aS)-3-oxo-2-(4-trifluoromethoxy-phenyl)-hexahydro-pyrrolo[1,2-c]imidazol-6-yl ester


name: (4-Fluoro-benzyl)-carbamic acid (6R,7aS)-3-oxo-2-(4-trifluoromethoxy-phenyl)-hexahydro-pyrrolo[1,2-c]imidazol-6-yl ester


name: cis-1-(1H-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-6-carboxylic acid methyl ester


A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively.


name: 4-{4-[8-(4-Cyano-phenyl)-[1,2,4]-triazolo[1,5-a]pyridin-2-ylamino]-phenyl}-piperidine-1-carboxylic acid tert-butyl ester


A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide.


KLK7_HUMAN Kallikrein-7 (sprot)

A kallikrein-7 that is encoded in the genome of human.


name: (S)-6-Amino-5-cyano-2-methoxycarbonylmethyl-4-(2-nitro-phenyl)-4H-pyran-3-carboxylic acid methyl ester


harmine

A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.


CASTANIN

A  4'-methoxyisoflavone that is isoflavone substituted by methoxy groups at positions 6 and 4' and a hydroxy group at position 7.


name: 2-thiophenecarboxylic acid [3-(3,5-dimethylphenoxy)-4-oxo-1-benzopyran-7-yl] ester


name: COT2_HUMAN COUP transcription factor 2 (sprot)

description: A COUP transcription factor 2 that is encoded in the genome of human.


name: 4-[[1-[[2-(4-Ethylphenyl)-5-methyl-oxazol-4-yl]methyl]nipecotoyl]amino]piperidine-1-carboxylic acid ethyl ester


AMPB_MOUSE Aminopeptidase B (sprot)

An aminopeptidase B that is encoded in the genome of mouse.


name: GLMS_ECOLI Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (sprot)

description: A glutamine--fructose-6-phosphate aminotransferase [isomerizing] that is encoded in the genome of Escherichia coli K-12.


An alpha-amino-acid anion that is the conjugate base of N(3)-fumaroyl-(S)-2,3-diaminopropanoic acid; major species at pH 7.3.


name: AROA_ECOLI 3-phosphoshikimate 1-carboxyvinyltransferase (sprot)

description: A 3-phosphoshikimate 1-carboxyvinyltransferase that is encoded in the genome of Escherichia coli K-12.


GLYPHOSATE

A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).


name: CAC1 proteinases 5,5 bicyclic inhibitor 45a


name: CAC1 proteinases 5,5 bicyclic inhibitor 10


name: CXCR2_HUMAN C-X-C chemokine receptor type 2 (sprot)

description: A C-X-C chemokine receptor type 2 that is encoded in the genome of human.


name: 4-[4-(3-Adamantan-1-yl-ureido)-piperidin-1-yl]-4-oxo-butyric acid methyl ester


name: 5-[4-(3-Adamantan-1-yl-ureido)-piperidin-1-yl]-5-oxo-pentanoic acid methyl ester


name: 2-[4-(3-Adamantan-1-yl-ureido)-piperidine-1-carbonyl]-benzoic acid methyl ester


name: IF4E_HUMAN Eukaryotic translation initiation factor 4E (sprot)

description: A eukaryotic translation initiation factor 4E that is encoded in the genome of human.


name: 4-{4-[(3-Adamantan-1-yl-ureido)-methyl]-piperidin-1-yl}-4-oxo-butyric acid methyl ester


name: 5-{4-[(3-Adamantan-1-yl-ureido)-methyl]-piperidin-1-yl}-5-oxo-pentanoic acid methyl ester


name: 2-{4-[(3-Adamantan-1-yl-ureido)-methyl]-piperidine-1-carbonyl}-benzoic acid methyl ester


name: 4-[4-(3-Adamantan-1-yl-ureido)-piperidine-1-carbonyl]-benzoic acid methyl ester


name: 3-[(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester


name: 7-Chloro-3-[(4-chloro-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 7-Chloro-4-oxo-1-phenyl-3-{[(pyridine-4-carbonyl)-amino]-methyl}-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 7-Chloro-4-oxo-1-phenyl-3-{[(pyridine-3-carbonyl)-amino]-methyl}-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 7-Chloro-3-(isobutyrylamino-methyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 7-Chloro-3-[(benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 3-(Benzoylamino-methyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 3-[(3-Chloro-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 7-Methoxy-3-[(3-methoxy-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quino-line-2-carboxylic acid methyl ester


name: 7-Methoxy-3-[(3,4-difluoro-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quino-line-2-carboxylic acid methyl ester


name: 3-[(4-tert-Butyl-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quino-line-2-carboxylic acid methyl ester


name: 3-[(4-Methoxy-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quino-line-2-carboxylic acid methyl ester


name: 7-Methoxy-4-oxo-1-phenyl-3-{[(pyridine-3-carbonyl)-amino]-methyl}-1,4-dihydroquin-oline-2-carboxylic acid methyl ester


name: 3-[(4-Fluoro-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 3-[(4-Dimethylamino-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 3-[(4-Chloro-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: (7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-carbamic acid phenyl ester


name: {4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-cyclohexyl}-carbamic acid tert-butyl ester


name: 3-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-pyrrolidine-1-carboxylic acid tert-butyl ester


name: 4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-cyclohexane-carboxylic acid methyl ester


name: 4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-piperidine-1-carboxylic acid phenyl ester


name: 4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-piperidine-1-carboxylic acid benzyl ester


name: 4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-benzoic acid methyl ester


name: 7-Chloro-3-(isoquinolin-1-ylaminomethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 7-Chloro-4-oxo-1-phenyl-3-(quinazolin-4-ylaminomethyl)-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: 7-Chloro-3-{[(morpholine-4-carbonyl)-amino]-methyl}-4-oxo-1-phenyl-1,4-dihydro-quino-line-2-carboxylic acid methyl ester


name: 7-Chloro-4-oxo-3-(phenoxycarbonylamino-methyl)-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester


name: CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (sprot)

description: A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human.


name: SC6A9_BOVIN Sodium- and chloride-dependent glycine transporter 1 (sprot)


name: P4HTM_HUMAN Transmembrane prolyl 4-hydroxylase (sprot)

description: A transmembrane prolyl 4-hydroxylase that is encoded in the genome of human.


name: CCR1_HUMAN C-C chemokine receptor type 1 (sprot)

description: A C-C chemokine receptor type 1 that is encoded in the genome of human.


name: VEGFA_HUMAN Vascular endothelial growth factor A, long form (sprot)

description: A vascular endothelial growth factor A, long form that is encoded in the genome of human.


name: AOC3_HUMAN Amine oxidase [copper-containing] 3 (sprot)

description: A membrane primary amine oxidase that is encoded in the genome of human.


BRYOSTATIN 1

A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.


name: METK_ECOSM S-adenosylmethionine synthase (sprot)


name: 5-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (4-d imethylaminomethyl-1H-imidazol-2-yl)-amide


name: ACVL1_MOUSE Serine/threonine-protein kinase receptor R3 (sprot)

description: A serine/threonine-protein kinase receptor R3 that is encoded in the genome of mouse.


A member of the class of quinolines that is quinoline substituted by a 6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl group at position 5. It is a potent ALK inhibitor (IC50 values of 2.4, 1.3, 85.8, 2,133 and 9,276 nM for ALK1, ALK2, ALK3, ALK4 and ALK5, respectively).