carnosine

A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.


Met-Ala

A dipeptide formed from L-methionine and L-alanine residues.


Gly-Asn

A dipeptide formed from glycine and L-asparagine residues.


8-aminooctanoic acid

An omega-amino fatty acid that is octanoic acid which carries an amino group at position 8.


cefotiam

A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalosporin antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.


name: S22A4_RAT Solute carrier family 22 member 4 (sprot)

description: A solute carrier family 22 member 4 that is encoded in the genome of rat.


name: S22A3_RAT Solute carrier family 22 member 3 (sprot)

description: A solute carrier family 22 member 3 that is encoded in the genome of rat.


SN-38 carboxylic acid

A 2-hydroxy monocarboxylic acid resulting from the hydrolysis of the delta-lactone ring of SN-38. It is a metabolite of SN-38.


ochratoxin A

A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.


latanoprost (free acid form)

A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension.


name: SO1C1_MOUSE Solute carrier organic anion transporter family member 1C1 (sprot)

description: A solute carrier organic anion transporter family member 1C1 that is encoded in the genome of mouse.


octanoic acid

A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.


name: S22A5_HUMAN Organic cation/carnitine transporter 2 (sprot)

description: An organic cation/carnitine transporter 2 that is encoded in the genome of human.


name: SO1B2_RAT Solute carrier organic anion transporter family member 1B2 (sprot)

description: A solute carrier organic anion transporter family member 1B3 that is encoded in the genome of rat.


AVID_CHICK Avidin (sprot)

A protein that is a translation product of the AVD gene in chicken.


SULFENTRAZONE

A member of the class of triazoles that is 5-oxo-1,2,4-triazole which is substituted at positions 1, 3, and 4 by 2,4-dichloro-5-[(methylsulfonyl)amino]phenyl, methyl, and difluoromethyl groups, respectively. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control broad-leaved weeds in soya and tobacco crops. Not approved for use within the European Union.


name: ODPA_PEA Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (sprot)


name: ODPB_PEA Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (sprot)


acetamiprid

A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group.


POTASSIUM CYANIDE

A cyanide salt containing equal numbers of potassium cations and cyanide anions.


An aldehyde that is furan substituted by a formyl group at position 3.


FURFURAL

An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.


CATA_BOVIN Catalase (sprot)

A catalase that is encoded in the genome of cow.


IMAZAQUIN

A quinolinemonocarboxylic acid that is quinoline-3-carboxylic acid which is substituted by a 4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl group at position 2.


name: UPP_ECOLI Uracil phosphoribosyltransferase (sprot)

description: A uracil phosphoribosyltransferase Upp that is encoded in the genome of Escherichia coli K-12.


MIROPROFEN

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(imidazo[1,2-a]pyridin-2-yl)phenyl group. A non-steroidal anti-inflammatory drug that also exhibits analgesic, antipyretic and platelet aggregation inhibition properties.


name: SP1_HUMAN Transcription factor Sp1 (sprot)

description: A transcription factor Sp1 that is encoded in the genome of human.


BROUSSONOL E

A pentahydroxyflavone that is flavone substituted with hydroxy groups at positions 3, 5, 7, 3' and 4' and prenyl groups at positions 6 and 5'. Isolated from Broussonetia papyrifera, it exhibits inhibitory activity against phospholipase A2 and tyrosinase.


ISOVITEXIN

A C-glycosyl compound that consists of apigenin substituted by a 1,5-anhydro-D-glucitol moiety at position 6.


DICLOCYMET

A diastereoisomeric mixture comprising equimolar amounts of (1R,2S)- and (1R,2R)-diclocymet. A fungicide used for the control of rice blast in paddy fields. It also shows some activity against paddy field insect pests including rice water weevil and rice-stem borer. Diclocymet is moderately toxic to fish.


name: HIS7_ECOLI Histidine biosynthesis bifunctional protein HisB (sprot)

description: A histidine biosynthesis bifunctional protein HisB that is encoded in the genome of Escherichia coli K-12.


name: 1H-Pyrrole-2-carboxylic acid, 5-formyl-3,4-dimethyl-, phenylmethyl ester


name: PSBA_SPIOL Photosystem II protein D1 (sprot)

description: A protein that is a translation product of the psbA gene in spinach.


LENACIL

A cyclopentapyrimidine that is 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione substituted by a cyclohexyl group at position 3.


(R)-IMAZAQUIN

A 2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]quinoline-3-carboxylic acid that has R-configuration. It is the more active enantiomer of imazaquin.


name: ACM1_DROME Muscarinic acetylcholine receptor DM1 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of fruit fly.


name: 2-oxo-1,4-dihydroquinazoline-3-carboxylic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester


name: P5CR1_ARATH Pyrroline-5-carboxylate reductase (sprot)

description: A pyrroline-5-carboxylate reductase that is encoded in the genome of Arabidopsis thaliana.


PYRACLOSTROBIN

A carbamate ester that is the methyl ester of [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]methoxycarbamic acid. A fungicide used to control major plant pathogens including Septoria tritici, Puccinia spp. and Pyrenophora teres.


CYB_PIG Cytochrome b (sprot)

A cytochrome b that is encoded in the genome of pig.


KRESOXIM-METHYL

A carboxylic ester that is the methyl ester of (2E)-(methoxyimino){2-[(2-methylphenoxy)methyl]phenyl}acetic acid. A fungicide for the control of scab on apples and pears and other fungal diseases on a wide range of crops.


AZOXYSTROBIN

An aryloxypyrimidine having a 4,6-diphenoxypyrimidine  skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.


name: 1A15_ARATH 1-aminocyclopropane-1-carboxylate synthase 5 (sprot)

description: A protein that is a translation product of the ACS5 gene in Arabidopsis thaliana.


name: ACH4_DROME Acetylcholine receptor subunit beta-like 2 (sprot)

description: A protein that is a translation product of the nAChRbeta2 gene in fruit fly.


ACES_DROME Acetylcholinesterase (sprot)

A protein that is a translation product of the Ace gene in fruit fly.


CHLORPYRIFOS

An  organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.


A racemate composed of (2S,3S)- and (2R,3R)-enantiomers of nemonapride. Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.


BUTHIONINE SULFOXIME

A 2-amino-4-(S-butylsulfonimidoyl)butanoic acid which has S-configuration. It is a inhibitor of gamma-glutamylcysteine synthetase and glutathione (GSH) biosynthesis and is capable of enhancing the apoptotic effects of several chemotherapeutic agents.


name: GSH1_RAT Glutamate--cysteine ligase catalytic subunit (sprot)

description: A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of rat.


name: GSH1_ONCVO Glutamate--cysteine ligase (sprot)


name: PDE4A_CAVPO 3',5'-cyclic-AMP phosphodiesterase 4A (Fragment) (sprot)


ERUCIC ACID

A docosenoic acid having a cis- double bond at C-13. It is found particularly in brassicas - it is a major component of mustard and rapeseed oils and is produced by broccoli, Brussels sprouts, kale, and wallflowers.


L-ornithine

An optically active form of ornithine having L-configuration.


acrivastine

A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urticaria, and rhinitis.


CATECHIN GALLATE

A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3S)-hydroxy group of (+)-catechin.


TOP2_YEAST DNA topoisomerase 2 (sprot)

A protein that is a translation product of the TOP2 gene in yeast.


ISOORIENTIN

A flavone C-glycoside consisting of luteolin having a beta-D-glucosyl residue at the 6-position.


TRICIN

The 3',5'-di-O-methyl ether of tricetin.  Known commonly as tricin, it is a constituent of rice bran and has been found to potently inhibit colon cancer cell growth.


A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.


name: GRIP1_RAT Glutamate receptor-interacting protein 1 (sprot)

description: A glutamate receptor-interacting protein 1 that is encoded in the genome of rat.


3-(indol-3-yl)propyl phosphate

An monoalkyl phosphate compound having an O-3-(indol-3-yl)propyl substituent.


name: TRPB_ECOLI Tryptophan synthase beta chain (sprot)

description: A tryptophan synthase beta chain that is encoded in the genome of Escherichia coli K-12.


CLOTHIANIDINE

A clothiadin that has E configuration at the C=N bond of the nitroguanidine moiety.


nitenpyram

A nitenpyram in which the double bond has E configuration.


name: UBP3_HUMAN Ubiquitin carboxyl-terminal hydrolase 3 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 3 that is encoded in the genome of human.


name: ACHA4_MOUSE Neuronal acetylcholine receptor subunit alpha-4 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of mouse.


name: EST5_RAT Liver carboxylesterase B-1 (sprot)

description: A protein that is a translation product of the Cesl1 gene in rat.


name: JHEA_TRINI Juvenile hormone esterase, isoform A (Fragments) (sprot)


name: JHEB_TRINI Juvenile hormone esterase, isoform B (Fragments) (sprot)


A member of the class of pyrroles that is 2,3-dihydro-1H-pyrrole substituted by a 2-methyl-3-oxodecanoyl group at the nitrogen atom. Isolated from Penicillium citrinum and Penicillium brevicompactum, it exhibits antifungal activity.


RYR3_MOUSE Ryanodine receptor 3 (sprot)

A ryanodine receptor 3 that is encoded in the genome of mouse.


name: C71B1_THLAR Cytochrome P450 71B1 (sprot)


name: PPOC_TOBAC Protoporphyrinogen oxidase, chloroplastic (sprot)


name: GLNAC_MAIZE Glutamine synthetase, chloroplastic (sprot)

description: A protein that is a translation product of the GLN2 gene in maize.


name: PETD_SPIOL Cytochrome b6-f complex subunit 4 (sprot)

description: A protein that is a translation product of the petD gene in spinach.


name: 2-(Trifluoromethyl)benzoic acid 2-benzoyl-1-tert-butyl hydrazide


name: Benzoic acid, 2,3-dimethyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide


USP_DROME Protein ultraspiracle (sprot)

A protein that is a translation product of the usp gene in fruit fly.


name: Benzoic acid, 2,4-dichloro-, 2-benzoyl-1-(1,1-dimethylethyl)hydrazide


name: Benzoic acid, 2-iodo-, 2-benzoyl-1-(1,1-dimethylethyl)hydrazide


name: USP_CHOFU Protein ultraspiracle homolog (sprot)


name: DXR_ARATH 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic (sprot)

description: A 1-deoxy-D-xylulose 5-phosphate reductoisomerase that is encoded in the genome of Arabidopsis thaliana.


name: ISPF_ARATH 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic (sprot)

description: A 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase that is encoded in the genome of Arabidopsis thaliana.


name: DXS_ARATH 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic (sprot)

description: A protein that is a translation product of the DXS gene in Arabidopsis thaliana.


name: ISPD_ARATH 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic (sprot)

description: A 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase that is encoded in the genome of Arabidopsis thaliana.


name: ISPE_SOLLC 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic/chromoplastic (Fragment) (sprot)


name: ISPE_ECOLI 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (sprot)

description: A 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase that is encoded in the genome of Escherichia coli K-12.


A monohydroxyflavanone in which the hydroxy group is located at position 3'.


name: DDL_HELPH D-alanine--D-alanine ligase (sprot)


name: DDLB_ECOLI D-alanine--D-alanine ligase B (sprot)

description: A D-alanine--D-alanine ligase B that is encoded in the genome of Escherichia coli K-12.


docosanoic acid

A straight-chain, C22, long-chain saturated fatty acid.


name: CCNB_PATPE G2/mitotic-specific cyclin-B (sprot)


name: 3MG1_ECOLI DNA-3-methyladenine glycosylase 1 (sprot)

description: A DNA-3-methyladenine glycosylase 1 that is encoded in the genome of Escherichia coli K-12.


name: DUS26_HUMAN Dual specificity protein phosphatase 26 (sprot)

description: A dual specificity protein phosphatase 26 that is encoded in the genome of human.


name: 4H-1-Benzopyran-2-carboxylic acid, 6-chloro-4-oxo-, ethyl ester


name: Chromone-2-carboxylic acid, n-propyl ester


P-NITROPHENOL

A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.


A member of the class of  phenols that is phenol carrying an allyl group at position 2.


name: LST8_HUMAN Target of rapamycin complex subunit LST8 (sprot)

description: A target of rapamycin complex subunit LST8 that is encoded in the genome of human.


ISOASPULVINONE E

A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts an E-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity.


name: NDUB9_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 that is encoded in the genome of human.


name: N''-[(Z)-(Naphthalen-2-yl)methylidene]carbonohydrazonic diamide--hydrogen chloride (1/1)


name: 1-Hydroxy-alpha-phenylcyclohexaneacetic acid (2-(diethylamino)ethyl) ester


FLAVOKAWAIN B

A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.


A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 2' and 6' and a methoxy group at position 4' respectively.


tedizolid

A member of the class of pyridines that is pyridine which is substituted by a 2-methyl-2H-tetrazol-5-yl group at position 2 and by a 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl group at position 5. It is used as its phosphate pro-drug used for the treatment of acute bacterial skin and skin structure infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.


A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.


FUCODIPHLOROETHOL G

A phlorotannin that consists of biphenyl-2,2',4,4',6-pentol substituted by a 2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy substituent at position 6'. Isolated from the marine brown alga Ecklonia cava, it exhibits anti-allergic, antioxidant and hypoglycemic activities.


A member of the class of chalcones that is isoliquiritigenin in which one of the hydroxy groups at position 2' is replaced by a methoxy group.


(PHENYLSULFONYL)BENZENE

A sulfone compound having two S-phenyl substituents. It has been found in plants like Gnidia glauca and Dioscorea bulbifera.


TBB3_HUMAN Tubulin beta-3 chain (sprot)

A tubulin beta-3 chain that is encoded in the genome of human.


ritodrine

A 4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol that has (1S,2R)-configuration.


name: 2-(1-Hydroxyethyl)-7-methoxypyrazolo[1,5-a]pyridine-4-carboxyl ic acid (3,5-dichloropyridin-4-yl)amide


name: 17beta-Acetoxy-3-methoxyestra-1,3,5(10)-triene; 3-Methoxy-1,3,5(10)-estratrien-17beta-ol Acetate; 3-Methoxy-17beta-acetoxyestra-1,3,5(10)-triene; Estradiol 17-Acetate 3-Methyl Ether; Estradiol 3-Methyl Ether 17-Acetate


perindopril

An alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline


name: 1,6-Dimethyl-2-oxo-4-thiophen-3-yl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid isopropyl ester


name: 4-(2-furanyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester


CHLOROLITHIUM

A metal chloride salt with a Li(+) counterion.


p-ANISIC ACID

A methoxybenzoic acid substituted with a methoxy group at position C-4.


A galloyl-beta-D-glucose compound having a galloyl group at the 1-position.


DESACETYL SALANNIN

A limonoid that is salannin in which the acetyloxy group at position 6 is replaced by a hydroxy group. It has been isolated from Azadirachta indica.


A bioactive sphingoid, sphinganine, in which the terminal hydroxy group has been replaced by a hydrogen.


name: ABHDB_HUMAN sn-1-specific diacylglycerol lipase ABHD11 (sprot)

description: An sn-1-specific diacylglycerol lipase ABHD11 that is encoded in the genome of human.


ISOGUANINE

An oxopurine that is 3,7-dihydro-purin-2-one in which the hydrogen at position 6 is substituted by an amino group.


name: phosphono [(2E,6E)-2,3,7,11-tetramethyldodeca-2,6,10-trienyl] hydrogen phosphate


name: MRGX1_MOUSE Mas-related G-protein coupled receptor member X1 (sprot)

description: A rodent-type Mas-related G-protein coupled receptor X1 that is encoded in the genome of mouse.


name: N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid sodium salt


name: MRGX1_RAT Mas-related G-protein coupled receptor member X1 (sprot)

description: A rodent-type Mas-related G-protein coupled receptor X1 that is encoded in the genome of rat.


name: EWS_HUMAN RNA-binding protein EWS (sprot)

description: An RNA-binding protein EWS that is encoded in the genome of human.


name: FLI1_HUMAN Friend leukemia integration 1 transcription factor (sprot)

description: A Friend leukemia integration 1 transcription factor that is encoded in the genome of human.


ITA2B_MOUSE Integrin alpha-IIb (sprot)

An integrin alpha-IIb that is encoded in the genome of mouse.


ITB3_MOUSE Integrin beta-3 (sprot)

An integrin beta-3 that is encoded in the genome of mouse.


ITAV_MOUSE Integrin alpha-V (sprot)

An integrin alpha-V that is encoded in the genome of mouse.


beta-erythroidine

An organic heterotetracyclic indole alkaloid isolated from the seeds and other parts of Erythrina species. It differs from the alpha isomer in having the double bond of the dihydropyranone ring located beta,gamma- to the lactone carbonyl group instead of alpha,beta-.


Pterin carrying a formyl group at position 6.


name: MP2K1_RAT Dual specificity mitogen-activated protein kinase kinase 1 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of rat.


name: MP2K2_RAT Dual specificity mitogen-activated protein kinase kinase 2 (sprot)

description: A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of rat.


dichlorobenzyl alcohol

A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines.


metronidazole

A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.


name: GPAT1_MOUSE Glycerol-3-phosphate acyltransferase 1, mitochondrial (sprot)

description: A glycerol-3-phosphate acyltransferase 1, mitochondrial that is encoded in the genome of mouse.


A cyclic ketone that is tropolone in which the hydrogens at positions 3 and 7 are substituted by hydroxy groups. It is isolated from the soil bacterium Streptomyces tropolofaciens strain K611-97.


HISPIDIN

Fungal metabolite first found in basidiomycete Inonotus hispidus (formerly Polyporus hispidus).


name: SECA1_STAA8 Protein translocase subunit SecA 1 (sprot)

description: A protein translocase subunit SecA that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325.


name: SECA2_STAA8 Protein translocase subunit SecA 2 (sprot)

description: A protein that is a translation product of the secA2 gene in Staphylococcus aureus subsp. aureus NCTC 8325.


hydrochloric acid

A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.


BROMIDE

A diatomic molecule containing covalently bonded hydrogen and bromine atoms.


THIOCYANIC ACID

A hydracid that is cyanic acid in which the oxygen is replaced by a sulfur atom.


IODIDE

A diatomic molecule containing covalently bonded hydrogen and iodine atoms.


SULFURIC ACID

A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.


name: NAS35_TELCI Zinc metalloproteinase dpy-31 (sprot)


name: NAS35_BRUMA Zinc metalloproteinase dpy-31 (sprot)


name: RFBF_SALTI Glucose-1-phosphate cytidylyltransferase (sprot)


LIPL_BOVIN Lipoprotein lipase (sprot)

A lipoprotein lipase that is encoded in the genome of cow.


A member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP).


name: Anthraquinone-2,6-disulfonic acid disodium salt


name: 5NTC_HUMAN Cytosolic purine 5'-nucleotidase (sprot)

description: A cytosolic purine 5'-nucleotidase that is encoded in the genome of human.


name: Methyl-carbamic acid 5,7-dibromo-2-oxo-benzo[1,3]oxathiol-6-yl ester


name: PGLD_CAMJE UDP-N-acetylbacillosamine N-acetyltransferase (sprot)


name: LY96_MOUSE Lymphocyte antigen 96 (sprot)

description: A lymphocyte antigen 96 that is encoded in the genome of mouse.


MYOF_HUMAN Myoferlin (sprot)

A myoferlin that is encoded in the genome of human.


THIAZOLIDINEDIONE

A thiazolidenedione carrying oxo substituents at positions 2 and 4.


name: KCNH1_HUMAN Potassium voltage-gated channel subfamily H member 1 (sprot)

description: A voltage-gated potassium channel KCNH1 that is encoded in the genome of human.


CTRB2_HUMAN Chymotrypsinogen B2 (sprot)

A chymotrypsinogen B2 that is encoded in the genome of human.


name: ISPF_SALTY 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (sprot)


name: SIN1_HUMAN Target of rapamycin complex 2 subunit MAPKAP1 (sprot)

description: A target of rapamycin complex 2 subunit MAPKAP1 that is encoded in the genome of human.


name: GLSK_MOUSE Glutaminase kidney isoform, mitochondrial (sprot)

description: A glutaminase kidney isoform, mitochondrial that is encoded in the genome of mouse.


name: TAF11_HUMAN Transcription initiation factor TFIID subunit 11 (sprot)

description: A transcription initiation factor TFIID subunit 11 that is encoded in the genome of human.


wogonin 7-O-beta-D-glucuronide

The glycosyloxyflavone which is the 7-O-glucuronide of wogonin.


icariside II

A glycosyloxyflavone that is 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone in which the hydroxy group at position 3 has been converted into its alpha-L-rhamnopyranoside.


hesperetin 7-O-beta-D-glucoside

A flavanone 7-O-beta-D-glucoside having hesperetin as the flavanone component.


PRDX1_HUMAN Peroxiredoxin-1 (sprot)

A peroxiredoxin-1 that is encoded in the genome of human.


name: ERCC1_HUMAN DNA excision repair protein ERCC-1 (sprot)

description: A DNA excision repair protein ERCC-1 that is encoded in the genome of human.


name: XPF_HUMAN DNA repair endonuclease XPF (sprot)

description: A DNA repair endonuclease XPF that is encoded in the genome of human.


A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.


name: 2-methyl-2-[3-((E)-2-nitro-vinyl)-phenoxy]-propionic acid ethyl ester


name: [2-[(2,4-Dioxopyrimidin-1-yl)methoxy]ethoxy-sulfanylphosphinothioyl] phosphono hydrogen phosphate


dimethyl fumarate

An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.


name: PGTB2_RAT Geranylgeranyl transferase type-2 subunit beta (sprot)

description: A geranylgeranyl transferase type-2 subunit beta that is encoded in the genome of rat.


name: JMJD6_HUMAN Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (sprot)

description: A bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 that is encoded in the genome of human.


name: QOR_HUMAN Quinone oxidoreductase (sprot)

description: A quinone oxidoreductase that is encoded in the genome of human.


name: NFSB_ECOLI Oxygen-insensitive NAD(P)H nitroreductase (sprot)

description: An oxygen-insensitive NAD(P)H nitroreductase that is encoded in the genome of Escherichia coli K-12.


mollebenzylanol B

A diterpenoid isolated from the leaves of Rhododendron molle.


name: IL1RA_HUMAN Interleukin-1 receptor antagonist protein (sprot)

description: An interleukin-1 receptor antagonist protein that is encoded in the genome of human.


DEGUELIN

A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.


TEPHROSIN

A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.


name: GLI2_MOUSE Zinc finger protein GLI2 (sprot)

description: A zinc finger protein GLI2 that is encoded in the genome of mouse.


name: HHAT_HUMAN Protein-cysteine N-palmitoyltransferase HHAT (sprot)

description: A protein-cysteine N-palmitoyltransferase HHAT that is encoded in the genome of human.


name: KCNK5_HUMAN Potassium channel subfamily K member 5 (sprot)

description: A potassium channel subfamily K member 5 that is encoded in the genome of human.


name: KCNKH_HUMAN Potassium channel subfamily K member 17 (sprot)

description: A potassium channel subfamily K member 17 that is encoded in the genome of human.


doxapram

A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.


name: KCNK9_RAT Potassium channel subfamily K member 9 (sprot)

description: A potassium channel subfamily K member 9 that is encoded in the genome of rat.


name: KCNK3_RAT Potassium channel subfamily K member 3 (sprot)

description: A potassium channel subfamily K member 3 that is encoded in the genome of rat.


idebenone

A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.


name: KCD12_HUMAN BTB/POZ domain-containing protein KCTD12 (sprot)

description: A BTB/POZ domain-containing protein KCTD12 that is encoded in the genome of human.


SPIN1_HUMAN Spindlin-1 (sprot)

A spindlin-1 that is encoded in the genome of human.


SPI2B_HUMAN Spindlin-2B (sprot)

A spindlin-2B that is encoded in the genome of human.


SPIN4_HUMAN Spindlin-4 (sprot)

A spindlin-4 that is encoded in the genome of human.


SPIN3_HUMAN Spindlin-3 (sprot)

A spindlin-3 that is encoded in the genome of human.


name: LOXL1_HUMAN Lysyl oxidase homolog 1 (sprot)

description: A lysyl oxidase homolog 1 that is encoded in the genome of human.


ent-dextilidine

An ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate that has R configuration at the carbon bearing the phenyl group and S configuration at the carbon bearing the dimethylamino group. It is the enantiomer of dextilidine; the opioid analgesic tilidine is the racemate comprising equimolar amounts of dextilidine and ent-dextilidine.


norfentanyl

A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of 4-(N'-phenyl)piperidin-4-amine with propanoic acid. A major metabolite of fentanyl.


cyclo(L-phenylalanyl-L-phenylalanyl)

A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which one hydrogen at position 3 and one hydrogen at position 6 are replaced by benzyl groups (the 3S,6S-diastereomer).


cyclo(L-tyrosyl-L-tyrosyl)

A cyclo(tyrosyl-tyrosyl) in which both stereocentres have L-configuration. Synthesized by Mycobacterium tuberculosis.


cyclo(L-tyrosyl-L-phenylalanyl)

A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which one hydrogen at position 3 and one hydrogen at position 6 are replaced by benzyl and 4-hydroxybenzyl groups (the 3S,6S-diastereomer).


name: QSOX1_HUMAN Sulfhydryl oxidase 1 (sprot)

description: A sulfhydryl oxidase 1 that is encoded in the genome of human.


L-KYNURENINE

A kynurenine that has L configuration.


resminostat

An enamide resulting from the formal condensation of the carboxy group of (2E)-3-[1-({4-[(dimethylamino)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]prop-2-enoic acid with the amino group of hydroxylamine. It is an orally bioavailable inhibitor of histone deacetylases with potential antineoplastic activity.


name: IRF3_HUMAN Interferon regulatory factor 3 (sprot)

description: An interferon regulatory factor 3 that is encoded in the genome of human.


name: MYD88_HUMAN Myeloid differentiation primary response protein MyD88 (sprot)

description: A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human.


name: TTBK1_HUMAN Tau-tubulin kinase 1 (sprot)

description: A tau-tubulin kinase 1 that is encoded in the genome of human.


name: TTBK2_HUMAN Tau-tubulin kinase 2 (sprot)

description: A tau-tubulin kinase 2 that is encoded in the genome of human.


parecoxib

An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib.


name: PEAK1_HUMAN Inactive tyrosine-protein kinase PEAK1 (sprot)

description: An inactive tyrosine-protein kinase PEAK1 that is encoded in the genome of human.


name: KCC1B_HUMAN Calcium/calmodulin-dependent protein kinase type 1B (sprot)

description: A calcium/calmodulin-dependent protein kinase type 1B that is encoded in the genome of human.


CCNO_HUMAN Cyclin-O (sprot)

A cyclin-O that is encoded in the genome of human.


name: ERN2_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE2 (sprot)

description: A serine/threonine-protein kinase/endoribonuclease IRE2 that is encoded in the genome of human.


name: KSR1_HUMAN Kinase suppressor of Ras 1 (sprot)

description: A kinase suppressor of Ras 1 that is encoded in the genome of human.


name: NEK8_HUMAN Serine/threonine-protein kinase Nek8 (sprot)

description: A serine/threonine-protein kinase Nek8 that is encoded in the genome of human.


name: PKN3_HUMAN Serine/threonine-protein kinase N3 (sprot)

description: A serine/threonine-protein kinase N3 that is encoded in the genome of human.


name: OSR1_HUMAN Protein odd-skipped-related 1 (sprot)

description: A protein odd-skipped-related 1 that is encoded in the genome of human.


name: TSSK6_HUMAN Testis-specific serine/threonine-protein kinase 6 (sprot)

description: A testis-specific serine/threonine-protein kinase 6 that is encoded in the genome of human.


CCNY_HUMAN Cyclin-Y (sprot)

A cyclin-Y that is encoded in the genome of human.


name: M3K21_HUMAN Mitogen-activated protein kinase kinase kinase 21 (sprot)

description: A mitogen-activated protein kinase kinase kinase 21 that is encoded in the genome of human.


GSK547 (GSK'547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.


name: LN28A_HUMAN Protein lin-28 homolog A (sprot)

description: A protein lin-28 homolog A that is encoded in the genome of human.


name: PD1L1_MOUSE Programmed cell death 1 ligand 1 (sprot)

description: A programmed cell death 1 ligand 1 that is encoded in the genome of mouse.


name: PD1L2_MOUSE Programmed cell death 1 ligand 2 (sprot)

description: A programmed cell death 1 ligand 2 that is encoded in the genome of mouse.


name: 3-({[1-(4-fluoro-phenyl)-1H-indazole-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester


iberin

An isothiocyanate that is 1-isothiocyanatopropane in which a hydrogen at position 3 has been replaced by a methylsulfinyl group. A glucosinolate hydrolysis product found in many members of the Brassicaceae family, it is a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa.


FLIDERSIACHROMONE

A member of the class of chromones that is chromone which is substituted by a 2-phenylethyl group at position 2. It is found in agarwood, a fragrant resinous heartwood obtained from certain trees in the genus Aquilaria.


name: TET1_HUMAN Methylcytosine dioxygenase TET1 (sprot)

description: A methylcytosine dioxygenase TET1 that is encoded in the genome of human.


name: TET2_HUMAN Methylcytosine dioxygenase TET2 (sprot)

description: A methylcytosine dioxygenase TET2 that is encoded in the genome of human.


LATRUNCULIN B

A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.


name: ACTS_RABIT Actin, alpha skeletal muscle (sprot)


DNLI3_HUMAN DNA ligase 3 (sprot)

A DNA ligase 3 that is encoded in the genome of human.


ALEURITOLIC ACID

A pentacyclic triterpenoid isolated from Maprounea africana and has been shown to exhibit inhibitory activity against HIV-1 reverse transcriptase.


DNLI4_HUMAN DNA ligase 4 (sprot)

A DNA ligase 4 that is encoded in the genome of human.


name: GLSK_RAT Glutaminase kidney isoform, mitochondrial (sprot)

description: A glutaminase kidney isoform, mitochondrial that is encoded in the genome of rat.


c-GMP-AMP

A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages.


name: 2'3'-Cyclic guanosine monothiophosphate-adenosine monophosphate


A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 2',5'-linkages.


cyclic di-AMP

A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of AMP.


name: 2'3'-Cyclic 3-deoxyguanosine monophosphate-adenosine monophosphate


(-)-JASMONIC ACID

A jasmonate ester that is the methyl ester of jasmonic acid.


name: CCG8_RAT Voltage-dependent calcium channel gamma-8 subunit (sprot)

description: A voltage-dependent calcium channel gamma-8 subunit that is encoded in the genome of rat.


name: NR1H2_RAT Oxysterols receptor LXR-beta (sprot)

description: An oxysterols receptor LXR-beta that is encoded in the genome of rat.


STRIGOL

A strigolactone in which the tricyclic lactone moiety bears a hydroxy substitutuent at the position para to the gem-dimethyl group.


name: ASIC2_MOUSE Acid-sensing ion channel 2 (sprot)

description: An acid-sensing ion channel 2 that is encoded in the genome of mouse.


name: ASIC1_MOUSE Acid-sensing ion channel 1 (sprot)

description: An acid-sensing ion channel 1 that is encoded in the genome of mouse.


name: OGFD1_HUMAN Prolyl 3-hydroxylase OGFOD1 (sprot)

description: A prolyl 3-hydroxylase OGFOD1 that is encoded in the genome of human.


name: 6-Chloro-2-(2-methoxy-ethoxy)-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexyl methyl)-amide


name: 6-Chloro-2-(2-hydroxy-ethylamino)-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexyl methyl)-amide


name: 6-Chloro-2-(2-methoxy-ethylamino)-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexyl methyl)-amide


name: 6-Chloro-2-cyclopent-1-enyl-quinoline-5-carboxylic acid (4,4-difluoro-cyclo hexyl methyl)-amide


name: GABT_MOUSE 4-aminobutyrate aminotransferase, mitochondrial (sprot)

description: A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of mouse.


pelabresib

An organic heterotricyclic compound that is 4H-[1,2]oxazolo[5,4-d][2]benzazepine substituted by methyl, 2-amino-2-oxoethyl, and 4-chlorophenyl groups at positions 1, 4S and 6, respectively. It is a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins and exhibits antineoplastic activity.


(R)-3-hydroxytetradecanoic acid

A 3-hydroxytetradecanoic acid that has R configuration at position 3. It plays an intermediate role in fatty acid biosynthesis.


3-hydroxylauric acid

A medium-chain fatty acid that is the 3-hydroxylated derivative of lauric acid;  associated with fatty acid metabolic disorders.


3-hydroxy capric acid

A medium-chain fatty acid that is decanoic acid substituted at position 3 by a hydroxy group.


undecanoic acid

A straight-chain, eleven-carbon saturated medium-chain fatty acid found in body fluids; the most fungitoxic of the C7:0 - C18:0 fatty acid series.


2-hydroxyoctanoic acid

A hydroxy fatty acid that is  caprylic (octanoic) acid substituted by a hydroxy group at position 2.


2-hydroxymyristic acid

A  long-chain fatty acid that is a derivative of myristic acid having a hydroxy substituent at C-2.


3-hydroxytetradecanoic acid

A 3-hydroxy fatty acid that is tetradecanoic (myristic) acid substituted at position 3 by a hydroxy group


TRIDECANOATE

A C13 straight-chain saturated fatty acid.


VADIMEZAN

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 5,6-dimethyl-9-oxoxanthen-4-yl group.


name: 2'3'-Cyclic guanosine monothiophosphate-adenosine monothiophosphate


name: 2,4-Thiazolidinedione, 5-((4-(2-(3-methoxyphenyl)-2-oxoethoxy)phenyl)methyl)-, potassium salt (1:1)


name: AAKB2_RAT 5'-AMP-activated protein kinase subunit beta-2 (sprot)

description: A 5'-AMP-activated protein kinase subunit beta-2 that is encoded in the genome of rat.


TRYB2_MOUSE Tryptase beta-2 (sprot)

A tryptase alpha/beta-1 that is encoded in the genome of mouse.


A glucarolactone formed via intramolecular cyclocondensation of the 5-hydroxy and 1-carboxy groups of D-glucaric acid.


name: I5P2_HUMAN Type II inositol 1,4,5-trisphosphate 5-phosphatase (sprot)

description: A type II inositol 1,4,5-trisphosphate 5-phosphatase that is encoded in the genome of human.


A phosphatidylcholine 24:0 in which the acyl groups at positions 1 and 2 are specified as lauroyl (dodecanoyl).


fondaparinux

A synthetic pentasaccharide which, apart from the O-methyl group at the reducing end of the molecule, consists of monomeric sugar units which are identical to a sequence of five monomeric sugar units that can be isolated after either chemical or enzymatic cleavage of the polymeric glycosaminoglycans heparin and heparan sulfate.


NUMIDARGISTAT

An aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours.


name: TA2R1_HUMAN Taste receptor type 2 member 1 (sprot)

description: A taste receptor type 2 member 1/119 that is encoded in the genome of human.


PEMETREXED DISODIUM

An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).


name: 3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid methyl ester


S26A4_MOUSE Pendrin (sprot)

A pendrin that is encoded in the genome of mouse.


S26A4_HUMAN Pendrin (sprot)

A pendrin that is encoded in the genome of human.


name: AAPK1_MOUSE 5'-AMP-activated protein kinase catalytic subunit alpha-1 (sprot)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of mouse.


name: SDHA_HUMAN Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sprot)

description: A succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial that is encoded in the genome of human.


CP4B1_HUMAN Cytochrome P450 4B1 (sprot)

A cytochrome P450 4B1 that is encoded in the genome of human.


name: 2-(P-Cyanophenyl methylidene hydrazino) adenosine


COCHINCHINOXANTHONE

A polycyclic cage xanthone isolated from the stems of Cratoxylum cochinchinense and has been shown to exhibit cytotoxic activity against human colon cancer cell line.


name: VPS4B_HUMAN Vacuolar protein sorting-associated protein 4B (sprot)

description: A vacuolar protein sorting-associated protein 4B that is encoded in the genome of human.


name: CLPX_HUMAN ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (sprot)

description: An ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial that is encoded in the genome of human.


name: STAT4_HUMAN Signal transducer and activator of transcription 4 (sprot)

description: A signal transducer and activator of transcription 4 that is encoded in the genome of human.


name: STA5B_MOUSE Signal transducer and activator of transcription 5B (sprot)

description: A signal transducer and activator of transcription 5b that is encoded in the genome of mouse.


name: KCMB4_HUMAN Calcium-activated potassium channel subunit beta-4 (sprot)

description: A calcium-activated potassium channel subunit beta-4 that is encoded in the genome of human.


name: GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 that is encoded in the genome of human.


name: GBG2_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (sprot)

description: A guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 that is encoded in the genome of human.


gallein

A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.


name: GNAQ_HUMAN Guanine nucleotide-binding protein G(q) subunit alpha (sprot)

description: A guanine nucleotide-binding protein G(q) subunit alpha that is encoded in the genome of human.


A hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and  L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist.


MAS_HUMAN Proto-oncogene Mas (sprot)

A G-protein coupled receptor MAS that is encoded in the genome of human.


name: DHYS_HUMAN Deoxyhypusine synthase (sprot)

description: A deoxyhypusine synthase that is encoded in the genome of human.


name: AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (sprot)

description: An aminoacyl tRNA synthase complex-interacting multifunctional protein 2 that is encoded in the genome of human.


PARACHLOROPHENOL

A monochlorophenol substituted at the pare position by a chlorine atom.


fludarabine phosphate

A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.


name: FUS_HRSVA Fusion glycoprotein F0 (sprot)


name: FPPS_MOUSE Farnesyl pyrophosphate synthase (sprot)

description: A farnesyl pyrophosphate synthase that is encoded in the genome of mouse.


name: IDI1_RAT Isopentenyl-diphosphate Delta-isomerase 1 (sprot)

description: An isopentenyl-diphosphate Delta-isomerase 1 that is encoded in the genome of rat.


name: FPPS_RAT Farnesyl pyrophosphate synthase (sprot)

description: A farnesyl pyrophosphate synthase that is encoded in the genome of rat.


DIMETHYLALLYL DIPHOSPHATE

A prenol phosphate that is a phosphoantigen comprising the O-pyrophosphate of prenol.


isopentenyl diphosphate

A prenol phosphate comprising 3-methylbut-3-en-1-ol having an O-diphosphate substituent.


name: IL5RA_MOUSE Interleukin-5 receptor subunit alpha (sprot)

description: An interleukin-5 receptor subunit alpha that is encoded in the genome of mouse.


name: CML1_MOUSE Chemerin-like receptor 1 (sprot)

description: A chemokine receptor-like protein CMKLR1 that is encoded in the genome of mouse.


name: GLCNE_HUMAN Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (sprot)

description: A bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase that is encoded in the genome of human.


desulfated gastrin-17

One of the primary forms of gastrin that is a 17-membered peptide consisting of Glp, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe-NH2 residues joined in sequence.


name: IP6K2_HUMAN Inositol hexakisphosphate kinase 2 (sprot)

description: An inositol hexakisphosphate kinase 2 that is encoded in the genome of human.


name: IPMK_HUMAN Inositol polyphosphate multikinase (sprot)

description: An inositol polyphosphate multikinase that is encoded in the genome of human.


name: TBA3C_HUMAN Tubulin alpha-3C chain (sprot)

description: A tubulin alpha-3 chain (human) that is a translation product of the TUBA3C gene in human.


name: TBA8_HUMAN Tubulin alpha-8 chain (sprot)

description: A tubulin alpha-8 chain that is encoded in the genome of human.


name: LARP7_HUMAN La-related protein 7 (sprot)

description: A La-related protein 7 that is encoded in the genome of human.


name: CISD2_HUMAN CDGSH iron-sulfur domain-containing protein 2 (sprot)

description: A CDGSH iron-sulfur domain-containing protein 2 that is encoded in the genome of human.


name: HSP72_HUMAN Heat shock-related 70 kDa protein 2 (sprot)

description: A heat shock-related 70 kDa protein 2 that is encoded in the genome of human.


name: KIF15_HUMAN Kinesin-like protein KIF15 (sprot)

description: A kinesin-like protein KIF15 that is encoded in the genome of human.


name: TRPC5_MOUSE Short transient receptor potential channel 5 (sprot)

description: A short transient receptor potential channel 5 that is encoded in the genome of mouse.


name: KAT6A_MOUSE Histone acetyltransferase KAT6A (sprot)

description: A histone acetyltransferase KAT6A that is encoded in the genome of mouse.


name: CDK20_HUMAN Cyclin-dependent kinase 20 (sprot)

description: A cyclin-dependent kinase 20 that is encoded in the genome of human.


name: CDK10_HUMAN Cyclin-dependent kinase 10 (sprot)

description: A cyclin-dependent kinase 10 that is encoded in the genome of human.


name: S26A3_MOUSE Chloride anion exchanger (sprot)

description: A chloride anion exchanger that is encoded in the genome of mouse.


FZD7_HUMAN Frizzled-7 (sprot)

A frizzled-7 that is encoded in the genome of human.


FZD1_HUMAN Frizzled-1 (sprot)

A frizzled-1 that is encoded in the genome of human.


name: TRMD_PSEAE tRNA (guanine-N(1)-)-methyltransferase (sprot)


name: TRMD_STAA8 tRNA (guanine-N(1)-)-methyltransferase (sprot)

description: A tRNA (guanine-N(1)-)-methyltransferase TrmD that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325.


name: TRMD_MYCTU tRNA (guanine-N(1)-)-methyltransferase (sprot)


name: TRPC4_HUMAN Short transient receptor potential channel 4 (sprot)

description: A short transient receptor potential cation channel TRPC4 that is encoded in the genome of human.


name: TRPC7_MOUSE Short transient receptor potential channel 7 (sprot)

description: A short transient receptor potential cation channel TRPC7 that is encoded in the genome of mouse.


name: STIM1_RAT Stromal interaction molecule 1 (sprot)

description: A stromal interaction molecule 1 that is encoded in the genome of rat.


name: ORAI1_RAT Calcium release-activated calcium channel protein 1 (sprot)

description: A calcium release-activated calcium channel protein 1 that is encoded in the genome of rat.


name: GUAA_HUMAN GMP synthase [glutamine-hydrolyzing] (sprot)

description: A GMP synthase [glutamine-hydrolyzing] that is encoded in the genome of human.


piperaquine

An aminoquinoline that is 1,3-di(piperazin-1-yl)propane in which the nitrogen at position 4 of each of the piperazine moieties is replaced by a 7-chloroquinolin-4-yl group.


UTRN_HUMAN Utrophin (sprot)

A utrophin that is encoded in the genome of human.


name: MLKL_HUMAN Mixed lineage kinase domain-like protein (sprot)

description: A mixed lineage kinase domain-like protein that is encoded in the genome of human.


CTNB1_MOUSE Catenin beta-1 (sprot)

A catenin beta-1 that is encoded in the genome of mouse.


name: EPS15_HUMAN Epidermal growth factor receptor substrate 15 (sprot)

description: An epidermal growth factor receptor substrate 15 that is encoded in the genome of human.


name: DDL_ENTFA D-alanine--D-alanine ligase (sprot)


A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.


calcifediol

A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.


name: ADCY8_HUMAN Adenylate cyclase type 8 (sprot)

description: An adenylate cyclase type 8 that is encoded in the genome of human.


name: RABP2_HUMAN Cellular retinoic acid-binding protein 2 (sprot)

description: A cellular retinoic acid-binding protein 2 that is encoded in the genome of human.


name: GLT14_HUMAN Polypeptide N-acetylgalactosaminyltransferase 14 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 14 that is encoded in the genome of human.


name: GLT13_HUMAN Polypeptide N-acetylgalactosaminyltransferase 13 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 13 that is encoded in the genome of human.


name: GALT3_HUMAN Polypeptide N-acetylgalactosaminyltransferase 3 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 3 that is encoded in the genome of human.


name: GLT10_HUMAN Polypeptide N-acetylgalactosaminyltransferase 10 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 10 that is encoded in the genome of human.


name: GALT6_HUMAN Polypeptide N-acetylgalactosaminyltransferase 6 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 6 that is encoded in the genome of human.


name: GALT1_HUMAN Polypeptide N-acetylgalactosaminyltransferase 1 (sprot)

description: A polypeptide N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


name: P5CR1_HUMAN Pyrroline-5-carboxylate reductase 1, mitochondrial (sprot)

description: A pyrroline-5-carboxylate reductase 1, mitochondrial that is encoded in the genome of human.


name: UCK2_HUMAN Uridine-cytidine kinase 2 (sprot)

description: A uridine-cytidine kinase 2 that is encoded in the genome of human.


A 6beta-hydroxy steroid that is androst-4-ene-3,17-dione substituted by a beta-hydroxy group at position 6.


name: NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 (sprot)

description: A methyltransferase-like protein 11A that is encoded in the genome of human.


name: UD11_RAT UDP-glucuronosyltransferase 1A1 (sprot)

description: A UDP-glucuronosyltransferase 1-2 that is encoded in the genome of rat.


A benzoxadiazole that is 2,1,3-benzoxadiazole which is substituted at position 4 by chlorine and at position 7 by a nitro group.


A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.


A member of the class of furans that is 5-methyl-2,3-dihydrofuran with a hydroxy group at position 4 and a keto group at position 3.


name: PGH2_CAVPO Prostaglandin G/H synthase 2 (sprot)


The [4,5-b]-fused isomer of imidazopyridine.


wilforol A

A pentacyclic triterpenoid with formula C29H38O5, originally isolated from the stems of Tripterygium regelii.


name: SET1B_HUMAN Histone-lysine N-methyltransferase SETD1B (sprot)

description: A histone-lysine N-methyltransferase SETD1B that is encoded in the genome of human.


RU 58668

A 17beta-hydroxy steroid that is 17beta-estradiol in the the hydrogen at the 11beta position has been replaced by a p-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl group. RU 58668 is a pure anti-estrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM).


DCNL4_HUMAN DCN1-like protein 4 (sprot)

A DCN1-like protein 4 that is encoded in the genome of human.


DCNL2_HUMAN DCN1-like protein 2 (sprot)

A DCN1-like protein 2 that is encoded in the genome of human.


DCNL3_HUMAN DCN1-like protein 3 (sprot)

A DCN1-like protein 3 that is encoded in the genome of human.


DCNL5_HUMAN DCN1-like protein 5 (sprot)

A DCN1-like protein 5 that is encoded in the genome of human.


3,4,5-TRIMETHOXYBENZOIC ACID

A benzoic acid derivative carrying 3-, 4- and 5-methoxy substituents.


name: SMS2_MOUSE Phosphatidylcholine:ceramide cholinephosphotransferase 2 (sprot)

description: A phosphatidylcholine:ceramide cholinephosphotransferase 2 that is encoded in the genome of mouse.


name: SMS1_MOUSE Phosphatidylcholine:ceramide cholinephosphotransferase 1 (sprot)

description: A phosphatidylcholine:ceramide cholinephosphotransferase 1 that is encoded in the genome of mouse.


name: NFE2_HUMAN Transcription factor NF-E2 45 kDa subunit (sprot)

description: A transcription factor NF-E2 45 kDa subunit that is encoded in the genome of human.


name: IP6K1_HUMAN Inositol hexakisphosphate kinase 1 (sprot)

description: An inositol hexakisphosphate kinase 1 that is encoded in the genome of human.


name: IP6K3_HUMAN Inositol hexakisphosphate kinase 3 (sprot)

description: An inositol hexakisphosphate kinase 3 that is encoded in the genome of human.


CO5_HUMAN Complement C5 (sprot)

A complement C5 that is encoded in the genome of human.


A tertiary carboxamide that is piperazine in which one of the amino groups has undergone condensation with the carboxy group of N-[(2,4-dichlorophenyl)sulfonyl]-L-serine, while the other has undergone condensation with the carboxy group of N-(1-benzothiophen-2-ylcarbonyl)-L-leucine. It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.


name: DOHH_HUMAN Deoxyhypusine hydroxylase (sprot)

description: A deoxyhypusine hydroxylase that is encoded in the genome of human.


deferiprone

A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.


name: TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (sprot)

description: A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of human.


A phenanthrol that is phenanthrene in which a hydrogen attached to a carbon in the central ring has been replaced by a hydroxy group.


name: ABD12_MOUSE Lysophosphatidylserine lipase ABHD12 (sprot)

description: A lysophosphatidylserine lipase ABHD12 that is encoded in the genome of mouse.


name: JAK2_RAT Tyrosine-protein kinase JAK2 (sprot)

description: A tyrosine-protein kinase JAK2 that is encoded in the genome of rat.


name: HPGDS_RAT Hematopoietic prostaglandin D synthase (sprot)

description: A glutathione-requiring prostaglandin D synthase that is encoded in the genome of rat.


name: CNGA2_RAT Cyclic nucleotide-gated channel alpha-2 (sprot)

description: A cyclic nucleotide-gated olfactory channel that is encoded in the genome of rat.


name: MQNE_THET8 Aminodeoxyfutalosine synthase (sprot)


(+)-dihydroisorhamnetin

A dihydroisorhamnetin that has 2R,3R-configuration.


name: [(2R)-2-methoxy-3-octadecoxypropyl] [(1S,2R,3S,4R,6R)-2,3,4-trihydroxy-6-(2-methylpropoxy)cyclohexyl] hydrogen phosphate


A pyrazolotriazine that is pyrazolo[1,5-a][1,3,5]triazine substituted by a piperidin-3-yloxy group, [2-(1H-pyrazol-1-yl)benzyl]nitrilo group and an isopropyl group at positions 2, 4 and 8 respectively. It is a potent and selective CDK7 inhibitor and exhibits antiviral activity.


name: LGUL_MOUSE Lactoylglutathione lyase (sprot)

description: A lactoylglutathione lyase that is encoded in the genome of mouse.


gerfelin

A member of the class of benzoic acids that is salicylic acid which is substituted at position 6 by a methyl group and at position 4 by a 2,3-dihydroxy-5-methylphenoxy group.


N-(3-oxohexanoyl)-L-homoserine lactone

An N-acyl-L-homoserine lactone having 3-oxohexanoyl as the acyl substituent.


name: AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of human.


name: AT2A3_MOUSE Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of mouse.


A member of the class of  hydroquinones that is benzene-1,4-diol substituted by tert-butyl groups at position 2 and 5.


name: AT2A3_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 3 that is encoded in the genome of human.


CHLOROCRESOL

A hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.


name: AT2A2_MOUSE Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (sprot)

description: A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of mouse.


name: PHOSPHOMETHYLPHOSPHONIC ACID GUANOSYL ESTER


FZD8_MOUSE Frizzled-8 (sprot)

A frizzled-8 that is encoded in the genome of mouse.


name: FFAR3_RAT Free fatty acid receptor 3 (sprot)

description: A free fatty acid receptor 3 that is encoded in the genome of rat.


selinexor

A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1Z)-3-oxo-3-[2-(pyrazin-2-yl)hydrazinyl]prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a prescription medicine approved for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma.


name: CDC20_HUMAN Cell division cycle protein 20 homolog (sprot)

description: A cell division cycle protein 20 homolog that is encoded in the genome of human.


name: SPOP_HUMAN Speckle-type POZ protein (sprot)

description: A speckle-type POZ protein that is encoded in the genome of human.


CP4Z1_HUMAN Cytochrome P450 4Z1 (sprot)

A cytochrome P450 4Z1 that is encoded in the genome of human.


CP4F8_HUMAN Cytochrome P450 4F8 (sprot)

A cytochrome P450 4F8 that is encoded in the genome of human.


CP4F3_HUMAN Cytochrome P450 4F3 (sprot)

A cytochrome P450 4F3 that is encoded in the genome of human.


name: CP4FC_HUMAN Cytochrome P450 4F12 (sprot)

description: A cytochrome P450 4F12 that is encoded in the genome of human.


name: GPX4_HUMAN Phospholipid hydroperoxide glutathione peroxidase GPX4 (sprot)

description: A phospholipid hydroperoxide glutathione peroxidase GPX4 that is encoded in the genome of human.


mevociclib

Mevociclib (SY-1365) is a selective CDK7 inhibitor. Mevociclib exhibits anti-proliferative and apoptotic effects in solid tumor cell lines. Mevociclib possesses anti-tumor activity in hematological and multiple aggressive solid tumors.


A member of the class of indoles that is 5-chloro-4-(1H-indol-3-yl)-N-[(3R)-piperidin-3-yl]pyrimidin-2-amine in which the piperidine NH group is substituted by a 4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}benzoyl group. It is a first-in-class CDK12 and CDK13 covalent kinase inhibitor with IC50 of 158 nM and 69 nM, respectively.


name: NEK10_HUMAN Serine/threonine-protein kinase Nek10 (sprot)

description: A serine/threonine-protein kinase Nek10 that is encoded in the genome of human.


name: I23O1_RAT Indoleamine 2,3-dioxygenase 1 (sprot)

description: An indoleamine 2,3-dioxygenase 1 that is encoded in the genome of rat.


(E)-beta-caryophyllene

A beta-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration. It is the most commonly occurring form of beta-caryophyllene, occurring in many essential oils, particularly oil of cloves.


name: GYS2_HUMAN Glycogen [starch] synthase, liver (sprot)

description: A glycogen [starch] synthase, liver that is encoded in the genome of human.


name: PSB5_MOUSE Proteasome subunit beta type-5 (sprot)

description: A proteasome subunit beta type-5 that is encoded in the genome of mouse.


name: PSB9_MOUSE Proteasome subunit beta type-9 (sprot)

description: A proteasome subunit beta type-9 that is encoded in the genome of mouse.


name: PSB2_MOUSE Proteasome subunit beta type-2 (sprot)

description: A proteasome subunit beta type-2 that is encoded in the genome of mouse.


name: PSB10_MOUSE Proteasome subunit beta type-10 (sprot)

description: A proteasome subunit beta type-10 that is encoded in the genome of mouse.


name: BDNF_HUMAN Brain-derived neurotrophic factor (sprot)

description: A brain-derived neurotrophic factor that is encoded in the genome of human.


PTN_HUMAN Pleiotrophin (sprot)

A pleiotrophin that is encoded in the genome of human.


name: DGKA_PIG Diacylglycerol kinase alpha (sprot)


1-oleoyl glycerol

A 1-monoglyceride where the acyl group is oleoyl.


name: DGKA_RAT Diacylglycerol kinase alpha (sprot)

description: A diacylglycerol kinase alpha that is encoded in the genome of rat.


name: PG12B_HUMAN Group XIIB secretory phospholipase A2-like protein (sprot)

description: A group XIIB secretory phospholipase A2-like protein that is encoded in the genome of human.


LERIGLITAZONE

A member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone.


CBPA2_HUMAN Carboxypeptidase A2 (sprot)

A carboxypeptidase A2 that is encoded in the genome of human.


CBPA4_HUMAN Carboxypeptidase A4 (sprot)

A carboxypeptidase A4 that is encoded in the genome of human.


name: CBPA3_RAT Mast cell carboxypeptidase A (Fragment) (sprot)


A crown ether that is cyclooctadecane in which the carbon atoms at positions 1, 4, 7, 10, 13 and 16 have been replaced by oxygen atoms.


mosapramine

A racemate comprising equimolar amounts of (R)- and (S)-mosapramine. It is a second-generation antipsychotic used for the treatment of schizophrenia.


sodium lauryl sulfate

An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.


myxochelin B

A member of the class of  benzamides obtained by formal condensation of the 1- and 6-amino groups of hexane-1,2,6-triamine with the carboxy groups from two molecules of 2,3-dihydroxybenzoic acid followed by reduction of the amide carbonyl at position 5 to a hydroxy group.


name: ATPG_MYCTU ATP synthase gamma chain (sprot)

description: An ATP synthase subunit gamma, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: ATPFD_MYCTU ATP synthase subunit b-delta (sprot)

description: A protein that is a translation product of the atpFH gene in Mycobacterium tuberculosis H37Rv.


name: SCN1B_HUMAN Sodium channel subunit beta-1 (sprot)

description: A sodium channel subunit beta-1 that is encoded in the genome of human.


SYS_STAA8 Serine--tRNA ligase (sprot)

A serine--tRNA ligase that is encoded in the genome of Staphylococcus aureus subsp. aureus NCTC 8325.


name: SYSC_HUMAN Serine--tRNA ligase, cytoplasmic (sprot)

description: A serine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


4-oxo-4-phenylbutyric acid

A 4-oxo monocarboxylic acid that is butyric acid bearing oxo and phenyl substituents at position 4.


4-oxo-4-(2-thienyl)butyric acid

A 4-oxo monocarboxylic acid that is butyric acid bearing oxo and 2-thienyl groups at position 4.


An abietane diterpenoid that is ferruginol in which a hydrogen of the bridgehead methyl group and the hydrogen ortho to the phenolic hydroxy group have both been replaced by hydroxy groups.


A pentacyclic triterpenoid that is oleanane which is substituted by hydroxy groups at the 3beta and 24 positions, and which has a double bond between positions 12 and 13.


A pentacyclic triterpenoid that is beta-amyrin carrying an additional hydroxy substituent at position 30 as well as an oxo group at position 11.


A diterpene consisting of taxane having two C=C double bonds at the 4(5)- and 11(12)-positions.


name: HDA10_MOUSE Polyamine deacetylase HDAC10 (sprot)

description: A polyamine deacetylase HDAC10 that is encoded in the genome of mouse.


name: TRPV2_MOUSE Transient receptor potential cation channel subfamily V member 2 (sprot)

description: A transient receptor potential cation channel TRPV2 that is encoded in the genome of mouse.


EPSILON-VINIFERIN

A stilbenoid that is the (-)-trans-stereoisomer of epsilon-viniferin, obtained by cyclodimerisation of trans-resveratrol.


name: ALF2_SYNY3 Fructose-bisphosphate aldolase class 2 (sprot)


name: URE1_ECOLX Urease subunit alpha (Fragment) (sprot)


Δ9-Tetrahydrocannabinolic acid

A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.


epigallocatechin

A flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration.


CANNABIGEROLIC ACID

A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a geranyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.


name: PDE12_HUMAN 2',5'-phosphodiesterase 12 (sprot)

description: A 2',5'-phosphodiesterase 12 that is encoded in the genome of human.


A member of the class of quinazolines that is quinazoline which is substituted at positions 2 and 4 by phenyl and (3-acetamidophenyl)nitrilo groups, respectively.


name: SPSB2_MOUSE SPRY domain-containing SOCS box protein 2 (sprot)

description: A SPRY domain-containing SOCS box protein 2 that is encoded in the genome of mouse.


name: 4-((4-(carboxymethyl) cyclohexyl) thio)-1-((6-chloro-1,3-benzodioxol-5-yl) methyl)-2-propyl-1H-imidazole-5-carboxylic acid


name: 3-Cyano-4,7-dihydro-7-oxo-5-phenyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid methyl ester


A member of the class of dibenzoazepines that is the amide formed from formal condensation of the carboxy group of 2,2-dimethyl-3-oxo-3-[(2,2,3,3,3-pentafluoropropyl)amino]propanoic acid with the amino group of (7S)-7-amino-5,7-dihydrodibenzo[b,d]azepin-6-one.


LEG7_MOUSE Galectin-7 (sprot)

A galectin-7 that is encoded in the genome of mouse.


LEG1_RAT Galectin-1 (sprot)

A galectin-1 that is encoded in the genome of rat.


A member of the class of phenylureas that is urea in which one of the nitrogens has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group, while the other has been substituted by a 3-fluoro-4-hydroxyphenyl group, the hydroxy group has been converted to the corresponding 1H-pyrazolo[3,4-d]pyrimidin-4-yl ether. It is an FLT3 (fms-like tyrosine kinase 3)and Wnt/beta-catenin signaling inhibitor.


name: 3-Thiazolidineacetic acid, 5-[[5-(5-carboxy-2-chlorophenyl)-2-furanyl]methylene]-2,4-dioxo-, methyl ester, (5Z)-


lividomycin

Any member of a family of aminoglycosidic antibiotics produced by the bacterium Streptomyces lividus. Note that one member of this class, lividomycin A, is also known as lividomycin.


urea

A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O).


FABP6_HUMAN Gastrotropin (sprot)

A gastrotropin that is encoded in the genome of human.


ESPL1_HUMAN Separin (sprot)

A separin that is encoded in the genome of human.


name: NGLY1_HUMAN Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (sprot)

description: A peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase that is encoded in the genome of human.


CASTANOSPERMINE

A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).


BATILOL

An alkylglycerol that is glycerol in which one of the primary hydroxy groups has been converted into the corresponding octadecyl ether. It is used in cosmetics as a stabilising ingredient and skin-conditioning agent.


name: TNR16_MOUSE Tumor necrosis factor receptor superfamily member 16 (sprot)

description: A tumor necrosis factor receptor superfamily member 16 that is encoded in the genome of mouse.


MAACKIAIN

The (-)-enantiomer of maackiain.


FADS2_RAT Acyl-CoA 6-desaturase (sprot)

An acyl-CoA 6-desaturase that is encoded in the genome of rat.


name: NF2L2_MOUSE Nuclear factor erythroid 2-related factor 2 (sprot)

description: A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of mouse.


name: PSB5_RAT Proteasome subunit beta type-5 (sprot)

description: A proteasome subunit beta type-5 that is encoded in the genome of rat.


HMOX2_HUMAN Heme oxygenase 2 (sprot)

A heme oxygenase 2 that is encoded in the genome of human.


name: STAR3_HUMAN StAR-related lipid transfer protein 3 (sprot)

description: A StAR-related lipid transfer protein 3 that is encoded in the genome of human.


P2RX3_MOUSE P2X purinoceptor 3 (sprot)

A P2X purinoceptor 3 that is encoded in the genome of mouse.


name: HCN4_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (sprot)

description: A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of mouse.


name: Carbamic acid, N-(2-amino-3-fluoro-4-(((4-fluorophenyl)methyl)amino)phenyl)-, ethyl ester


lobophytumin E

A diterpenoid isolated from the Hainan soft coral Lobophytum cristatum.


LOBOPHYTUMIN C

A  diterpenoid that is decahydronaphthalene substituted by a methyl group at position 4a, a methylidiene group at position 1 and a 6-methylhepta-1,5-dien-2-yl group at position 7 (the 4aS,7S,8aR-stereoisomer). It has been isolated from the Hainan soft coral Lobophytum cristatum.


name: TAOK2_RAT Serine/threonine-protein kinase TAO2 (sprot)

description: A serine/threonine-protein kinase TAO2 that is encoded in the genome of rat.


atromentin

A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione which is substituted by a 4-hydroxyphenyl group at positions 3 and 6. It is a mushroom pigment isolated from several fungi species and acts as a smooth muscle stimulant, and exhibits anticoagulant, antibacterial and antineoplastic properties.


name: MARK4_MOUSE MAP/microtubule affinity-regulating kinase 4 (sprot)

description: A MAP/microtubule affinity-regulating kinase 4 that is encoded in the genome of mouse.


mefuparib

A member of the class of 1-benzofurans that is 1-benzofuran substituted by 4-[(methylamino)methyl]phenyl, fluoro and aminocarbonyl groups at positions 2, 5, and 7, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 3.2 nM and 1.9 nM, respectively). The compound exhibits anti-cancer properties and has also shown promising antiviral activity against the virus that causes COVID-19.


OLEOYL GLYCINE

A fatty acid derivative that is the 9Z-octadecenoyl derivative of glycine. It is believed to be an intermediate in oleamide biosynthesis.


N-arachidonoyl-L-alanine

An N-acyl-L-alanine resulting from the formal condensation of the amino group of L-alanine with the carboxy group of arachidonic acid.


O-palmitoyl-L-carnitine

An O-acyl-L-carnitine in which the acyl group is specified as palmitoyl (hexadecanoyl).


N-oleoyl-L-leucine

An L-leucine derivative resulting from the formal condensation of the carboxy group of oleic acid with the amino group of L-leucine.


N-oleoyl-L-serine

An L-serine derivative resulting from the formal condensation of the carboxy group of oleic acid with the amino group of L-serine.


N-oleoyl-L-glutamic acid

A fatty amide resulting from the formal condensation of the carboxy group of oleic acid with the amino group of L-glutamic acid.


(R)-oleoylcarnitine

An O-acyl-L-carnitine in which the acyl group is specified as oleoyl.


N-oleoyl-L-phenylalanine

An N-acyl-L-phenylalanine resulting from the formal condensation of the carboxy group of oleic acid with the amino group of L-phenylalanine.


N-arachidonyl-γ-aminobutyric acid

An N-acyl-gamma-aminobutyric acid resulting from the formal condensation of the amino group of gamma-aminobutyric acid with the carboxy group of arachidonic acid.


tunicamycin B2

A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 13-methyltetradec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety.


ARGI1_MOUSE Arginase-1 (sprot)

An arginase-1 that is encoded in the genome of mouse.


A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2.


Imidazole substituted at position 4 by a methyl group.


OLODATEROL HYDROCHLORIDE

A hydrochloride obtained by combining olodaterol with one equivalent of hydrochloric acid. Used for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.


1-palmitoleoyl-sn-glycerol 3-phosphate

A 1-acyl-sn-glycerol 3-phosphate in which the 1-acyl substituent is specified as palmitoleoyl.


name: GRP75_HUMAN Stress-70 protein, mitochondrial (sprot)

description: A stress-70 protein, mitochondrial that is encoded in the genome of human.


ATX2_MOUSE Ataxin-2 (sprot)

An ataxin-2 that is encoded in the genome of mouse.


name: PDIA1_BOVIN Protein disulfide-isomerase (sprot)


name: CXCR6_HUMAN C-X-C chemokine receptor type 6 (sprot)

description: A C-X-C chemokine receptor type 6 that is encoded in the genome of human.


name: CXCR6_MOUSE C-X-C chemokine receptor type 6 (sprot)

description: A C-X-C chemokine receptor type 6 that is encoded in the genome of mouse.


A member of the class of pterocarpans that is (6aR,11aR)-pterocarpan substituted by hydroxy groups at positions 3 and 9, a methoxy group at position 1 and a prenyl groups at positions 2 and 8. It has been isolated from Glycyrrhiza uralensis.


gancaonin I

A member of the class of 1-benzofurans which consists of 1-benzofuran substituted by methoxy groups at positions 4 and 6, a prenyl group at position 5 and a 2,4-dihydroxyphenyl group at position 2. It has been isolated from Glycyrrhiza uralensis.


name: PD1L2_HUMAN Programmed cell death 1 ligand 2 (sprot)

description: A programmed cell death 1 ligand 2 that is encoded in the genome of human.


A  methoxyaurone that is  aureusidin in which the hydroxy groups at positions  4, 6, 3' and 4' have been replaced by methoxy groups respectively. It has been isolated from the roots of Cyperus teneriffae.


CFAB_MOUSE Complement factor B (sprot)

A complement factor B that is encoded in the genome of mouse.


An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.


name: RAB6A_HUMAN Ras-related protein Rab-6A (sprot)

description: A Ras-related protein Rab-6A that is encoded in the genome of human.


name: KCD11_HUMAN BTB/POZ domain-containing protein KCTD11 (sprot)

description: A BTB/POZ domain-containing protein KCTD11 that is encoded in the genome of human.


name: AP1B1_HUMAN AP-1 complex subunit beta-1 (sprot)

description: An AP-1 complex subunit beta-1 that is encoded in the genome of human.


TETRAC

A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.


KUMANON G

A tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity.


TECTORIDIN

A glycosyloxyisoflavone that is  tectorigenin substituted by a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.


name: 1-(4-Benzyloxy benzoyl) 2-(2-cyano ethyl) hydrazine


BGLR_MOUSE Beta-glucuronidase (sprot)

A beta-glucuronidase that is encoded in the genome of mouse.


rose bengal (photoactivated)

A xanthene dye that is fluorescein bearing bromine substituents at positions 2', 4', 5' and 7' (on the xanthene ring) and iodine substituents at position 2, 3, 4, and 5 (on the phenyl ring). The dipotassium salt is the biological stain 'rose bengal'.


A naphthofuran that is naphtho[2,3-b]furan-4,9-dione substituted by a hydroxy group at position 5 and a 1-hydroxyethyl group at position 2 (the S stereoisomer). Isolated from Tabebuia impetiginosa and Tabebuia avellanedae, it exhibits antineoplastic activity.


CATA_HUMAN Catalase (sprot)

A catalase that is encoded in the genome of human.


(11Z)-icos-11-enoic acid

An icosenoic acid having a cis- double bond at position 11.


name: NAA50_HUMAN N-alpha-acetyltransferase 50 (sprot)

description: An N-alpha-acetyltransferase 50 that is encoded in the genome of human.


acetyl CoA

An acyl-CoA having acetyl as its S-acetyl component.


name: CPSM_HUMAN Carbamoyl-phosphate synthase [ammonia], mitochondrial (sprot)

description: A carbamoyl-phosphate synthase [ammonia], mitochondrial that is encoded in the genome of human.


name: LMTK3_HUMAN Serine/threonine-protein kinase LMTK3 (sprot)

description: A serine/threonine-protein kinase LMTK3 that is encoded in the genome of human.


N-(4-aminobenzoyl)-L-glutamic acid

A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.


DIAMINOPYRIMIDINE

An aminopyrimidine in which a pyrimidine nucleus is substituted with amino groups at C-2 and C-4.


TLR9_MOUSE Toll-like receptor 9 (sprot)

A Toll-like receptor 9 that is encoded in the genome of mouse.


name: ESTD_HUMAN S-formylglutathione hydrolase (sprot)

description: An S-formylglutathione hydrolase that is encoded in the genome of human.


name: Phosphoric acid, diethyl 1-naphthalenyl ester


name: SCN2B_HUMAN Sodium channel subunit beta-2 (sprot)

description: A sodium channel subunit beta-2 that is encoded in the genome of human.


name: SCN1B_MOUSE Sodium channel subunit beta-1 (sprot)

description: A sodium channel subunit beta-1 that is encoded in the genome of mouse.


name: SCN2B_MOUSE Sodium channel subunit beta-2 (sprot)

description: A sodium channel subunit beta-2 that is encoded in the genome of mouse.


A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers.


name: DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A (sprot)

description: A DNA (cytosine-5)-methyltransferase 3A that is encoded in the genome of mouse.


FOSB_HUMAN Protein FosB (sprot)

A protein FosB that is encoded in the genome of human.


name: JUND_HUMAN Transcription factor JunD (sprot)

description: A transcription factor JunD that is encoded in the genome of human.


name: IRAK4_MOUSE Interleukin-1 receptor-associated kinase 4 (sprot)

description: An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of mouse.


name: PLAT2_HUMAN Phospholipase A and acyltransferase 2 (sprot)

description: A phospholipase A and acyltransferase 2 that is encoded in the genome of human.


name: PLAT3_HUMAN Phospholipase A and acyltransferase 3 (sprot)

description: A phospholipase A and acyltransferase 3 that is encoded in the genome of human.


name: PLAT4_HUMAN Phospholipase A and acyltransferase 4 (sprot)

description: A phospholipase A and acyltransferase 4 that is encoded in the genome of human.


name: PLAT5_HUMAN Phospholipase A and acyltransferase 5 (sprot)

description: A phospholipase A and acyltransferase 5 that is encoded in the genome of human.


bisphenol AF

An organofluorine compound that is  bisphenol A with its methyl hydrogens replaced by fluorines.


name: TADBP_HUMAN TAR DNA-binding protein 43 (sprot)

description: A TAR DNA-binding protein 43 that is encoded in the genome of human.


name: CHLE_CANLF Cholinesterase (Fragment) (sprot)


5,6-epoxyeicosatrienoic acid

An EET obtained by formal epoxidation of the 5,6-double bond of arachidonic acid.


name: PR15A_HUMAN Protein phosphatase 1 regulatory subunit 15A (sprot)

description: A protein phosphatase 1 regulatory subunit 15A that is encoded in the genome of human.


name: PR15B_HUMAN Protein phosphatase 1 regulatory subunit 15B (sprot)

description: A protein phosphatase 1 regulatory subunit 15B that is encoded in the genome of human.


delgocitinib

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a (3S,4R)-1-(cyanoacetyl)-3-methyl-1,6-diazaspiro[3.4]octan-6-yl group at position 4. It is a pan-Janus kinase (JAK) inhibitor and is approved for treatment of atopic dermatitis (AD) in Japan.


S17A5_HUMAN Sialin (sprot)

A sialin that is encoded in the genome of human.


name: Carbamic acid, [(1S,2S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester


A tetrapeptide that is an IAP antagonist.


A secondary carboxamide resulting from the formal condensation of the carboxy group of [(4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetic acid with the amino group of 4-(difluoromethoxy)aniline. It is a specific matrix metalloproteinase-9 (MMP-9) inhibitor.


5NTD_MOUSE 5'-nucleotidase (sprot)

A 5'-nucleotidase that is encoded in the genome of mouse.


name: ODC_HUMAN Mitochondrial 2-oxodicarboxylate carrier (sprot)

description: A mitochondrial 2-oxodicarboxylate carrier that is encoded in the genome of human.


name: S6A14_HUMAN Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (sprot)

description: A sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) that is encoded in the genome of human.


(S)-blebbistatin

The (S)-enantiomer of blebbistatin.


An N-acylpiperazine that is piperazine substituted by 5-methyl-4-nitro-1,2-oxazole-3-carbonyl and bis(4-chlorophenyl)methyl groups at positions 1 and 4, respectively. It is a glutathione peroxidase 4 (GPX4) inhibitor which induces ferroptosis in cancer cells expressing the RAS oncogene.


name: PF2R_RAT Prostaglandin F2-alpha receptor (sprot)

description: A prostaglandin F2-alpha receptor that is encoded in the genome of rat.


name: LYPA1_MOUSE Acyl-protein thioesterase 1 (sprot)

description: An acyl-protein thioesterase 1 that is encoded in the genome of mouse.


name: LYPA2_MOUSE Acyl-protein thioesterase 2 (sprot)

description: An acyl-protein thioesterase 2 that is encoded in the genome of mouse.


name: ACHG_RAT Acetylcholine receptor subunit gamma (sprot)

description: A eukaryotic translation initiation factor 4E type 2 that is encoded in the genome of rat.


name: ACHD_RAT Acetylcholine receptor subunit delta (sprot)

description: An acetylcholine receptor subunit delta that is encoded in the genome of rat.


name: ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (sprot)

description: An aspartyl/asparaginyl beta-hydroxylase that is encoded in the genome of human.


name: MBOA4_MOUSE Ghrelin O-acyltransferase (sprot)

description: A ghrelin O-acyltransferase that is encoded in the genome of mouse.


SPF45_HUMAN Splicing factor 45 (sprot)

A splicing factor 45 that is encoded in the genome of human.


name: CGL_MOUSE Cystathionine gamma-lyase (sprot)

description: A cystathionine gamma-lyase that is encoded in the genome of mouse.


name: GPR84_MOUSE G-protein coupled receptor 84 (sprot)

description: A G-protein coupled receptor 84 that is encoded in the genome of mouse.


TRIGONELLINE

An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group.


A member of the class of phenols that is guaiacol in which the hydrogen para- to the hydroxy group is replaced by a vinyl group.


A methylcatechol having a single methyl substituent at the 4-position. It has been isolated from Picea abies.


trans-isoeugenol

The trans-stereoisomer of isoeugenol.


A methylcatechol carrying a methyl substituent at position 3. It is a xenobiotic metabolite produced by some bacteria capable of degrading nitroaromatic compounds present in pesticide-contaminated soil samples.


AGO2_HUMAN Protein argonaute-2 (sprot)

A protein argonaute-2 that is encoded in the genome of human.


sulfisomidine

A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.


asenapine

A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine. Used as its maleate salt for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.


name: FGF23_HUMAN Fibroblast growth factor 23 (sprot)

description: A fibroblast growth factor 23 that is encoded in the genome of human.


name: ACSL6_HUMAN Long-chain-fatty-acid--CoA ligase 6 (sprot)

description: A long-chain-fatty-acid--CoA ligase 6 that is encoded in the genome of human.


name: ACSL3_HUMAN Fatty acid CoA ligase Acsl3 (sprot)

description: A fatty acid CoA ligase Acsl3 that is encoded in the genome of human.


name: ACSL1_MOUSE Long-chain-fatty-acid--CoA ligase 1 (sprot)

description: A long-chain-fatty-acid--CoA ligase 1 that is encoded in the genome of mouse.


name: ACSL1_HUMAN Long-chain-fatty-acid--CoA ligase 1 (sprot)

description: A long-chain-fatty-acid--CoA ligase 1 that is encoded in the genome of human.


name: 2,2-Dimethyl-propionic acid 3-(2-chloro-6-methylaminopurin-9-YL)-2-(2,2-dimethyl-propionyloxymethyl)-propyl ester


N-benzylhexadecanamide

A macamide resulting from the formal condensation of the carboxy group of hexadecanoic acid with benzylamine. A moderate inhibitor of fatty acid amide hydrolase.


name: BAZ1A_HUMAN Bromodomain adjacent to zinc finger domain protein 1A (sprot)

description: A bromodomain adjacent to zinc finger domain protein 1A that is encoded in the genome of human.


GALC_MOUSE Galactocerebrosidase (sprot)

A galactocerebrosidase that is encoded in the genome of mouse.


dasabuvir

A member of the class of pyrimidone, which is (as the monohydrate of its sodium salt) in combination with ombitasvir, paritaprevir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.


HYDANTOIN

An imidazolidinone with oxo groups at position 2 and 4.


N-methylhydantoin

A imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin.


uracil

A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription.


A pyrimidone that is uracil with a methyl group substituent at position 1.


name: Dithiocarbonic acid S-(2-aminoethyl) S-benzyl ester hydrochloride


name: TRPV5_HUMAN Transient receptor potential cation channel subfamily V member 5 (sprot)

description: A transient receptor potential cation channel subfamily V member 5 that is encoded in the genome of human.


prednisone

A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.


name: PDIA3_HUMAN Protein disulfide-isomerase A3 (sprot)

description: A protein disulfide-isomerase A3 that is encoded in the genome of human.


name: PDIA4_HUMAN Protein disulfide-isomerase A4 (sprot)

description: A protein disulfide-isomerase A4 that is encoded in the genome of human.


name: TXND5_HUMAN Thioredoxin domain-containing protein 5 (sprot)

description: A thioredoxin domain-containing protein 5 that is encoded in the genome of human.


name: PDIA6_HUMAN Protein disulfide-isomerase A6 (sprot)

description: A protein disulfide-isomerase A6 that is encoded in the genome of human.


name: N-[2-keto-1-[3-(piperonylamino)propyl]pyrimidin-4-yl]carbamic acid benzyl ester


name: EPHB3_MOUSE Ephrin type-B receptor 3 (sprot)

description: An ephrin type-B receptor 3 that is encoded in the genome of mouse.


name: EPHA5_RAT Ephrin type-A receptor 5 (sprot)

description: An ephrin type-A receptor 5 that is encoded in the genome of rat.


name: EPHA6_MOUSE Ephrin type-A receptor 6 (sprot)

description: An ephrin type-A receptor 6 that is encoded in the genome of mouse.


name: EPHA8_MOUSE Ephrin type-A receptor 8 (sprot)

description: An ephrin type-A receptor 8 that is encoded in the genome of mouse.


name: ADCY2_HUMAN Adenylate cyclase type 2 (sprot)

description: An adenylate cyclase type 2 that is encoded in the genome of human.


ACRIDINE

A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.


An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the amino group of 2,5-dibromoaniline. It is a dual-function inhibitor of Bruton's tyrosine kinase (BTK) and Polo-like kinases (PLK) that exhibits anticancer properties.


name: TRBP2_HUMAN RISC-loading complex subunit TARBP2 (sprot)

description: A RISC-loading complex subunit TARBP2 that is encoded in the genome of human.


name: [(2R,3S,4R,5R)-5-(6-amino-8-butylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate


name: ENTP1_MOUSE Ectonucleoside triphosphate diphosphohydrolase 1 (sprot)

description: An ectonucleoside triphosphate diphosphohydrolase 1 that is encoded in the genome of mouse.


TLR5_HUMAN Toll-like receptor 5 (sprot)

A Toll-like receptor 5 that is encoded in the genome of human.


name: MYLK2_RABIT Myosin light chain kinase 2, skeletal/cardiac muscle (sprot)


A tripeptide comprising of L-arginine, 3-methyl-L-valine and L-arginine joined in sequence by peptide linkages and in which the amino terminus is substituted by a [4-(carbamimidamidomethyl)phenyl]acetyl group and the carboxy terminus is substituted by a (4-carbamimidoylbenzyl)amino group. It is a highly potent inhibitor of furin endoprotease (Ki = 5.5 pM) that has anti-infectious activity.


name: SYMM_HUMAN Methionine--tRNA ligase, mitochondrial (sprot)

description: A methionyl-tRNA synthetase, mitochondrial that is encoded in the genome of human.


chloramphenicol

An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions.


purine type


SAP_HUMAN Prosaposin (sprot)

A prosaposin that is encoded in the genome of human.


PROCYANIDIN B1

A proanthocyanidin consisting of (-)-epicatechin and (+)-catechin units joined by a bond between positions 4 and 8' respectively  in a beta-configuration.. Procyanidin B1 can be found in Cinnamomum verum (Ceylon cinnamon, in the rind, bark or cortex), in Uncaria guianensis (cat's claw, in the root), and in Vitis vinifera (common grape vine, in the leaf) or in peach.


phytomenadione

A member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones.


name: GPT_HUMAN UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (sprot)

description: A UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that is encoded in the genome of human.


PERM_MOUSE Myeloperoxidase (sprot)

A myeloperoxidase that is encoded in the genome of mouse.


eupatin

A trimethoxyflavone that is quercetagetin methylated at positions 4', 6 and 7.


name: FGF14_HUMAN Fibroblast growth factor 14 (sprot)

description: A fibroblast growth factor 14 that is encoded in the genome of human.


name: DOCK5_MOUSE Dedicator of cytokinesis protein 5 (sprot)

description: A dedicator of cytokinesis protein 5 that is encoded in the genome of mouse.


name: DOCK5_HUMAN Dedicator of cytokinesis protein 5 (sprot)

description: A dedicator of cytokinesis protein 5 that is encoded in the genome of human.


SCOPARONE

A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.


name: NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (sprot)

description: A histone-lysine N-methyltransferase NSD3 that is encoded in the genome of human.


name: GOPC_HUMAN Golgi-associated PDZ and coiled-coil motif-containing protein (sprot)

description: A Golgi-associated PDZ and coiled-coil motif-containing protein that is encoded in the genome of human.


name: NHRF2_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (sprot)

description: A Na(+)/H(+) exchange regulatory cofactor NHE-RF2 that is encoded in the genome of human.


name: ACKR3_CANLF Atypical chemokine receptor 3 (sprot)


name: ACKR3_RAT Atypical chemokine receptor 3 (sprot)

description: An atypical chemokine receptor 3 that is encoded in the genome of rat.


name: PLC_BACCE 1-phosphatidylinositol phosphodiesterase (sprot)


WHILE OLIVETOL

A member of the class of resorcinols that is resorcinol in which the hydrogen at position 5 is replaced by a pentyl group.


CARDOL

Resorcinol substituted at position 5 by a pentadecyl chain.


Primin

A 1,4-benzoquinone having a methoxy substituent at the 2-position and a pentyl substituent at the 6-position.


ANO1_MOUSE Anoctamin-1 (sprot)

An anoctamin-1 that is encoded in the genome of mouse.


ANO2_MOUSE Anoctamin-2 (sprot)

An anoctamin-2 that is encoded in the genome of mouse.


A secondary carboxamide resulting from the formal condensation of the carboxy group of 1-methyl-1H-pyrazole-5-carboxylic acid with the amino group of 2-methyl-4-[(2-methylphenyl)diazenyl]aniline. It is a potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM).


NONANOATE

A C9 straight-chain saturated fatty acid which occurs naturally as esters of the oil of pelargonium. Has antifungal properties, and is also used as a herbicide as well as in the preparation of plasticisers and lacquers.