regulation of heart morphogenesis

description: Any process that modulates the frequency, rate or extent of heart morphogenesis.


transcription export complex 2

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p.


DUBm complex

description: A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p.


name: nuclear-transcribed mRNA catabolic process, non-stop decay

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.


name: NAD-dependent histone H3K14 deacetylase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.


name: NAD-dependent histone H4K16 deacetylase activity

description: Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.


regulation of mating type switching

description: Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus.


regulation of DNA stability

description: Any process that modulates the stability of DNA.


name: negative regulation of DNA amplification

description: Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification.


name: positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling

description: Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud.


name: negative regulation of protein kinase activity by regulation of protein phosphorylation

description: The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.


name: regulation of myeloid cell apoptotic process

description: Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.


regulation of B cell apoptotic process

description: Any process that modulates the frequency, rate, or extent of B cell apoptotic process.


SAGA complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof.


allantois development

description: The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure.


lateral mesodermal cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell.


name: planar cell polarity pathway involved in axis elongation

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.


N-glycan processing

description: The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.


name: contractile actin filament bundle assembly

description: Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.


inner cell mass cellular morphogenesis

description: The morphogenesis of cells in the inner cell mass.


chemorepulsion of axon

description: The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


chemoattraction of axon

description: The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


name: positive regulation of blood vessel remodeling

description: Any process that activates or increases the frequency, rate or extent of blood vessel remodeling.


name: regulation of synaptic vesicle fusion to presynaptic active zone membrane

description: Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.


name: regulation of neuron projection regeneration

description: Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.


name: regulation of platelet-derived growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.


embryonic lung development

description: The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure.


name: cerebellar cortex structural organization

description: The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


name: regulation of skeletal muscle fiber differentiation

description: Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation.


name: regulation of tyrosine phosphorylation of STAT protein

description: Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: regulation of activation of Janus kinase activity

description: Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.


type I interferon receptor binding

description: Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).


name: protein phosphorylated amino acid binding

description: Binding to a phosphorylated amino acid residue within a protein.


postsynaptic specialization assembly

description: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane.


reelin-mediated signaling pathway

description: The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


activation of GTPase activity

description: Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.


cerebellar neuron development

description: The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


name: regulation of cell adhesion mediated by integrin

description: Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin.


helper T cell diapedesis

description: The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.


lamellipodium morphogenesis

description: A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized.


platelet alpha granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets.


name: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2 (mouse)

description: A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2 that is encoded in the genome of mouse.


name: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1 (mouse)

description: A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1 that is encoded in the genome of mouse.


positive regulation of rRNA processing

description: Any process that activates or increases the frequency, rate or extent of rRNA processing.


regulation of kinetochore assembly

description: Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


transcription export complex

description: The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.


RNA helicase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of an RNA helicase.


name: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

description: Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


name: negative regulation of immature T cell proliferation in thymus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus.


name: negative regulation of mitotic DNA replication initiation from late origin

description: Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication.


name: negative regulation of DNA-templated DNA replication initiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.


name: protein localization to chromosome, telomeric region

description: Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.


regulation of tissue remodeling

description: Any process that modulates the frequency, rate, or extent of tissue remodeling.


DNA repair complex

description: A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.


meiotic cell cycle process

description: A process that is part of the meiotic cell cycle.


DNA recombinase disassembly

description: The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases).


inner kinetochore

description: The region of a kinetochore closest to centromeric DNA which contains many CENP proteins organized in various subcomplexes including CENP-C, CENP-LN, CENP-HIKM, CENP-OPQUR and CENP-TWSX, but excluding the CENP-A containing heterochromatin.


achiasmate meiosis I

description: The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata.


Barr body

description: A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.


name: negative regulation of chromosome condensation

description: Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.


name: regulation of type B pancreatic cell proliferation

description: Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.


cellular response to interferon-alpha

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.


response to alkaloid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.


spectrin-associated cytoskeleton

description: The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane.


hemoglobin complex

description: An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.


spectrin

description: Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.


name: porphyrin-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.


oxygen binding

description: Binding to oxygen (O2).


RNAi effector complex

description: Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins.


male sex differentiation

description: The establishment of the sex of a male organism by physical differentiation.


cytochrome complex assembly

description: The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.


protein farnesylation

description: The covalent attachment of a farnesyl group to a protein.


positive regulation of immune response

description: Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.


name: humoral immune response mediated by circulating immunoglobulin

description: An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.


name: early endosome to late endosome transport

description: The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.


description: Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.


name: positive regulation of type I hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.


box C/D snoRNP assembly

description: The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.


name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis

description: The process in which the terminal end of a mammary duct bifurcates.


transcription factor TFIID complex

description: A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.


name: RNA polymerase I transcription regulator complex

description: A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I.


name: DNA-templated transcription open complex formation

description: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.


name: RNA polymerase II complex recruiting activity

description: Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.


small nuclear ribonucleoprotein complex

description: A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs.


name: RNA splicing, via transesterification reactions

description: Splicing of RNA via a series of two transesterification reactions.


name: negative regulation of cardiac muscle cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.


nuclear retinoid X receptor binding

description: Binding to a nuclear retinoid X receptor.


nuclear retinoic acid receptor binding

description: Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.


name: nuclear thyroid hormone receptor binding

description: Binding to a nuclear thyroid hormone receptor.


histone deacetylase regulator activity

description: Binds to and modulates the activity of histone deacetylase.


name: cellular response to Thyroglobulin triiodothyronine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.


name: regulation of thyroid hormone mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.


name: NR1H3_MOUSE Oxysterols receptor LXR-alpha (sprot)

description: An oxysterols receptor LXR-alpha that is encoded in the genome of mouse.


histone deacetylase complex

description: A protein complex that possesses histone deacetylase activity.


protein retention in ER lumen

description: The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.


name: retrograde transport, vesicle recycling within Golgi

description: The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.


sialyltransferase activity

description: Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.


name: acetyl-CoA transmembrane transporter activity

description: Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.


description: Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R.


description: Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.


description: Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H+.


HNK-1 sulfotransferase activity

description: Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R).


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R.


description: Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP.


name: B4GT5_HUMAN Beta-1,4-galactosyltransferase 5 (sprot)

description: A beta-1,4-galactosyltransferase 5 that is encoded in the genome of human.


name: FUT9_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (sprot)

description: A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 that is encoded in the genome of human.


name: B3GL1_HUMAN UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (sprot)

description: A UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 that is encoded in the genome of human.


name: CEGT_HUMAN Ceramide glucosyltransferase (sprot)

description: A ceramide glucosyltransferase that is encoded in the genome of human.


name: ACATN_HUMAN Acetyl-coenzyme A transporter 1 (sprot)

description: An acetyl-coenzyme A transporter 1 that is encoded in the genome of human.


name: B4GN2_HUMAN Beta-1,4 N-acetylgalactosaminyltransferase 2 (sprot)

description: A beta-1,4 N-acetylgalactosaminyltransferase 2 that is encoded in the genome of human.


name: PMGT1_HUMAN Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (sprot)

description: A protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 that is encoded in the genome of human.


name: EMC5_HUMAN ER membrane protein complex subunit 5 (sprot)

description: An ER membrane protein complex subunit 5 that is encoded in the genome of human.


name: FUT3_HUMAN 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (sprot)

description: A 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 that is encoded in the genome of human.


An alpha-1,4-N-acetylglucosaminyltransferase that is encoded in the genome of human.


name: ATP7B_HUMAN Copper-transporting ATPase 2 (sprot)

description: A copper-transporting ATPase 2 that is encoded in the genome of human.


name: MANEA_HUMAN Glycoprotein endo-alpha-1,2-mannosidase (sprot)

description: A glycoprotein endo-alpha-1,2-mannosidase that is encoded in the genome of human.


name: MGAT3_HUMAN Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (sprot)

description: A beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.


name: CHSTA_HUMAN Carbohydrate sulfotransferase 10 (sprot)

description: A carbohydrate sulfotransferase 10 that is encoded in the genome of human.


name: CHST8_HUMAN Carbohydrate sulfotransferase 8 (sprot)

description: A carbohydrate sulfotransferase 8 that is encoded in the genome of human.


name: MGT5A_HUMAN Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (sprot)

description: An alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A that is encoded in the genome of human.


name: B3GT2_HUMAN Beta-1,3-galactosyltransferase 2 (sprot)

description: A beta-1,3-galactosyltransferase 2 that is encoded in the genome of human.


name: B3GT4_HUMAN Beta-1,3-galactosyltransferase 4 (sprot)

description: A beta-1,3-galactosyltransferase 4 that is encoded in the genome of human.


name: FUT4_HUMAN Alpha-(1,3)-fucosyltransferase 4 (sprot)

description: An alpha-(1,3)-fucosyltransferase 4 that is encoded in the genome of human.


name: FUT6_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (sprot)

description: A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 that is encoded in the genome of human.


name: FUT5_HUMAN 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (sprot)

description: A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 that is encoded in the genome of human.


name: FUT7_HUMAN Alpha-(1,3)-fucosyltransferase 7 (sprot)

description: An alpha-(1,3)-fucosyltransferase 7 that is encoded in the genome of human.


name: FUT11_HUMAN Alpha-(1,3)-fucosyltransferase 11 (sprot)

description: An alpha-(1,3)-fucosyltransferase 11 that is encoded in the genome of human.


name: FUT10_HUMAN Alpha-(1,3)-fucosyltransferase 10 (sprot)

description: An alpha-(1,3)-fucosyltransferase 10 that is encoded in the genome of human.


name: MGT4C_HUMAN Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (sprot)

description: An alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C that is encoded in the genome of human.


name: B4GT6_HUMAN Beta-1,4-galactosyltransferase 6 (sprot)

description: A beta-1,4-galactosyltransferase 6 that is encoded in the genome of human.


name: MGT4A_HUMAN Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (sprot)

description: An alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A that is encoded in the genome of human.


name: MGT4B_HUMAN Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (sprot)

description: An alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B that is encoded in the genome of human.


name: B3GT5_HUMAN Beta-1,3-galactosyltransferase 5 (sprot)

description: A beta-1,3-galactosyltransferase 5 that is encoded in the genome of human.


name: B3GT1_HUMAN Beta-1,3-galactosyltransferase 1 (sprot)

description: A beta-1,3-galactosyltransferase 1 that is encoded in the genome of human.


glucagon

A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.


MONASCIN

An organic heterotricyclic compound that is 3a,4,8,9a-tetrahydro-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione that is substituted at positions 3, 6, and 9a by hexanoyl, (1E)-prop-1-en-1-yl and methyl groups, respectively (the 3S,3aR,9aR diastereoisomer). One of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mould rice), it is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.


name: positive regulation of fatty acid transport

description: Any process that activates or increases the frequency, rate or extent of fatty acid transport.


name: negative regulation of toll-like receptor 9 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway.


NEUM_HUMAN Neuromodulin (sprot)

A neuromodulin that is encoded in the genome of human.


name: cellular response to diacyl bacterial lipopeptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus.


name: RELB_HUMAN Transcription factor RelB (sprot)

description: A transcription factor RelB that is encoded in the genome of human.


fatty acid binding

description: Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.


organelle

description: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.


phospholipid efflux

description: The directed movement of a phospholipid out of a cell or organelle.


name: ventricular cardiac muscle tissue morphogenesis

description: The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.


interleukin-1 alpha production

description: The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


cerebral cortex subventricular zone

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


specification of animal organ identity

description: The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


amygdala development

description: The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.


central gray substance of midbrain

description: Periaqueductal gray (PAG; also called the 'central gray') is the gray matter located around the cerebral aqueduct within the midbrain. It plays a role in the descending modulation of pain and in defensive behaviour. The ascending pain and temperature fibers of the spinothalamic tract also send information to the PAG via the spinomesencephalic tract. The spinomesencephalic tract is so-named because the fibers originate in the spine and terminate in the mesencephalon, another name for the midbrain, the part of the brain in which the PAG resides. [WP,unvetted].


astrocyte of the cerebellum

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An astrocyte of the cerebellum.


nephric duct morphogenesis

description: The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.


leukocyte proliferation

description: The expansion of a leukocyte population by cell division.


nucleate erythrocyte differentiation

description: The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.


platelet morphogenesis

description: Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.


macrophage homeostasis

description: The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


name: regulation of cytokine production involved in inflammatory response

description: Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.


name: plasmacytoid dendritic cell differentiation

description: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.


name: negative regulation of myeloid cell apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.


hemostasis

description: The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.


name: PEX19_HUMAN Peroxisomal biogenesis factor 19 (sprot)

description: A peroxisomal biogenesis factor 19 that is encoded in the genome of human.


name: PEX3_HUMAN Peroxisomal biogenesis factor 3 (sprot)

description: A peroxisomal biogenesis factor 3 that is encoded in the genome of human.


medium-chain fatty acid transport

description: The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


cellular detoxification

description: Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


negative regulation of ferroptosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis.


name: gamma-secretase subunit APH-1A isoform 2 (mouse)

description: A gamma-secretase subunit APH-1A isoform 2 that is encoded in the genome of mouse.


name: gamma-secretase subunit APH-1A isoform 1 (mouse)

description: A gamma-secretase subunit APH-1A isoform 1 that is encoded in the genome of mouse.


heteroduplex formation

description: The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.


protein flavinylation

description: The addition of a flavin group to a protein amino acid.


name: mitochondrial respiratory chain complex II assembly

description: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane.


name: mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

description: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.


name: negative regulation of interleukin-1 beta production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.


name: ubiquitin-like protein peptidase activity

description: An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins.


name: negative regulation of interleukin-18 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.


dendritic cell dendrite assembly

description: Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.


nuclear pore transmembrane ring

description: A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.


central plaque of spindle pole body

description: One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope.


spindle pole body localization

description: Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells.


glucose mediated signaling pathway

description: The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes.


name: monoatomic cation transmembrane transporter activity

description: Enables the transfer of cation from one side of a membrane to the other.


name: amino acid export across plasma membrane

description: The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.


bleomycin

A glycopeptide produced by the bacterium Streptomyces verticillus. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2.


gentian violet

An iminium ion that is malachite green cation in which the hydrogen at the para- psition of the monosubstituted phenyl group is replaced by a dimethylamino group.


name: efflux transmembrane transporter activity

description: Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.


intracellular polyamine homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of polyamine within a cell.


gamma-tubulin binding

description: Binding to the microtubule constituent protein gamma-tubulin.


sister chromatid segregation

description: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.


name: negative regulation of microtubule polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.


name: karyogamy involved in conjugation with cellular fusion

description: During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.


name: nuclear migration involved in conjugation with cellular fusion

description: The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion.


name: protein localization to mitotic spindle pole body

description: A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body.


name: protein localization to microtubule plus-end

description: A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end.


name: mitotic spindle orientation checkpoint signaling

description: A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.


nuclear microtubule

description: Any microtubule in the nucleus of a cell.


name: plus-end-directed microtubule motor activity

description: A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.


tubulin-dependent ATPase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate.


meiotic sister chromatid segregation

description: The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle.


name: plus-end specific microtubule depolymerization

description: The removal of tubulin heterodimers from the plus end of a microtubule.


name: regulation of mitotic spindle elongation

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle.


spindle elongation

description: The cell cycle process in which the distance is lengthened between poles of the spindle.


chromatin insulator sequence binding

description: Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription.


name: snoRNA transcription by RNA polymerase II

description: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.


midbrain morphogenesis

description: The developmental process by which a midbrain is generated and organized.


heart trabecula morphogenesis

description: The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


vitellogenesis

description: The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.


name: negative regulation of Ras protein signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.


name: regulation of Ras protein signal transduction

description: Any process that modulates the frequency, rate or extent of Ras protein signal transduction.


mesenchyme condensation cell

description: A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.


cerebellar cortex formation

description: The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


placenta blood vessel development

description: The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure.


labyrinthine layer development

description: The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state.


MBF transcription complex

description: A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.


name: NUD19_HUMAN Acyl-coenzyme A diphosphatase NUDT19 (sprot)

description: An acyl-coenzyme A diphosphatase NUDT19 that is encoded in the genome of human.


name: NUDT7_HUMAN Peroxisomal coenzyme A diphosphatase NUDT7 (sprot)

description: A peroxisomal coenzyme A diphosphatase NUDT7 that is encoded in the genome of human.


sulfur compound metabolic process

description: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.


taurine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.


anatomical structure homeostasis

description: A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


skin morphogenesis

description: The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.


olfactory placode morphogenesis

description: The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.


olfactory nerve formation

description: The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


detoxification of inorganic compound

description: Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds.


detoxification

description: Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


platelet dense granule membrane

description: The lipid bilayer surrounding the platelet dense granule.


9-O-acetylneuraminic acid

The acetate ester of the primary hydroxy group of neuraminic acid.


N-acylsphingoid

A ceramide consisting of an undefined sphingoid base linked to an undefined fatty acid via an amide bond.


name: PILRA_HUMAN Paired immunoglobulin-like type 2 receptor alpha (sprot)

description: A paired immunoglobulin-like type 2 receptor alpha that is encoded in the genome of human.


name: SLAF6_HUMAN SLAM family member 6 (sprot)

description: A SLAM family member 6 that is encoded in the genome of human.


name: PP65_HCMVA 65 kDa phosphoprotein (sprot)


name: KI2L1_HUMAN Killer cell immunoglobulin-like receptor 2DL1 (sprot)

description: A killer cell immunoglobulin-like receptor 2DL1 that is encoded in the genome of human.


name: OX2G_HUMAN OX-2 membrane glycoprotein (sprot)

description: An OX-2 membrane glycoprotein that is encoded in the genome of human.


name: MO2R1_HUMAN Cell surface glycoprotein CD200 receptor 1 (sprot)

description: A cell surface glycoprotein CD200 receptor 1 that is encoded in the genome of human.


name: KI3L2_HUMAN Killer cell immunoglobulin-like receptor 3DL2 (sprot)

description: A killer cell immunoglobulin-like receptor 3DL2 that is encoded in the genome of human.


PVR_HUMAN Poliovirus receptor (sprot)

A poliovirus receptor that is encoded in the genome of human.


name: KLRG1_HUMAN Killer cell lectin-like receptor subfamily G member 1 (sprot)

description: A killer cell lectin-like receptor subfamily G member 1 that is encoded in the genome of human.


name: CXAR_HUMAN Coxsackievirus and adenovirus receptor (sprot)

description: A coxsackievirus and adenovirus receptor that is encoded in the genome of human.


name: JAML_HUMAN Junctional adhesion molecule-like (sprot)

description: A junctional adhesion molecule-like that is encoded in the genome of human.


name: LAIR2_HUMAN Leukocyte-associated immunoglobulin-like receptor 2 (sprot)

description: A leukocyte-associated immunoglobulin-like receptor 2 that is encoded in the genome of human.


CD226_HUMAN CD226 antigen (sprot)

A CD226 molecule that is encoded in the genome of human.


name: SLAF7_HUMAN SLAM family member 7 (sprot)

description: A SLAM family member 7 that is encoded in the genome of human.


name: TACT_HUMAN T-cell surface protein tactile (sprot)

description: A T-cell surface protein tactile that is encoded in the genome of human.


name: KI3L1_HUMAN Killer cell immunoglobulin-like receptor 3DL1 (sprot)

description: A killer cell immunoglobulin-like receptor 3DL1 that is encoded in the genome of human.


name: NR3L1_HUMAN Natural cytotoxicity triggering receptor 3 ligand 1 (sprot)

description: A natural cytotoxicity triggering receptor 3 ligand 1 that is encoded in the genome of human.


CD99_HUMAN CD99 antigen (sprot)

A CD99 molecule that is encoded in the genome of human.


BY55_HUMAN CD160 antigen (sprot)

A CD160 molecule that is encoded in the genome of human.


name: KI2L4_HUMAN Killer cell immunoglobulin-like receptor 2DL4 (sprot)

description: A killer cell immunoglobulin-like receptor 2DL4 that is encoded in the genome of human.


name: CRTAM_HUMAN Cytotoxic and regulatory T-cell molecule (sprot)

description: A cytotoxic and regulatory T-cell molecule that is encoded in the genome of human.


name: KLRD1_HUMAN Natural killer cells antigen CD94 (sprot)

description: A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of human.


name: NKG2A_HUMAN NKG2-A/NKG2-B type II integral membrane protein (sprot)

description: An NKG2-A/NKG2-B type II integral membrane protein that is encoded in the genome of human.


name: NCTR2_HUMAN Natural cytotoxicity triggering receptor 2 (sprot)

description: A natural cytotoxicity triggering receptor 2 that is encoded in the genome of human.


name: CLM7_HUMAN CMRF35-like molecule 7 (sprot)

description: A CMRF35-like molecule 7 that is encoded in the genome of human.


name: CLM2_HUMAN CMRF35-like molecule 2 (sprot)

description: A CMRF35-like molecule 2 that is encoded in the genome of human.


CD22_HUMAN B-cell receptor CD22 (sprot)

A B-cell receptor CD22 that is encoded in the genome of human.


name: LIRA5_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 5 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 5 that is encoded in the genome of human.


name: SH21B_HUMAN SH2 domain-containing protein 1B (sprot)

description: An SH2 domain-containing protein 1B that is encoded in the genome of human.


name: SIGL6_HUMAN Sialic acid-binding Ig-like lectin 6 (sprot)

description: A sialic acid-binding Ig-like lectin 6 that is encoded in the genome of human.


name: SH21A_HUMAN SH2 domain-containing protein 1A (sprot)

description: An SH2 domain-containing protein 1A that is encoded in the genome of human.


name: LIRA1_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 1 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 1 that is encoded in the genome of human.


name: LIRB5_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 5 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 5 that is encoded in the genome of human.


HEMA_I34A1 Hemagglutinin (sprot)

A hemagglutinin subtype H1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Puerto Rico/8/1934.


name: hematopoietic progenitor cell antigen CD34 isoform hCD34-F (human)

description: A hematopoietic progenitor cell antigen CD34 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28906-1.


name: FCG2B_HUMAN Low affinity immunoglobulin gamma Fc region receptor II-b (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor II-b that is encoded in the genome of human.


name: KI2L2_HUMAN Killer cell immunoglobulin-like receptor 2DL2 (sprot)

description: A killer cell immunoglobulin-like receptor 2DL2 that is encoded in the genome of human.


name: KI2L3_HUMAN Killer cell immunoglobulin-like receptor 2DL3 (sprot)

description: A killer cell immunoglobulin-like receptor 2DL3 that is encoded in the genome of human.


name: LIRA4_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 4 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 4 that is encoded in the genome of human.


name: CLM6_HUMAN CMRF35-like molecule 6 (sprot)

description: A CMRF35-like molecule 6 that is encoded in the genome of human.


name: MICB_HUMAN MHC class I polypeptide-related sequence B (sprot)

description: An MHC class I polypeptide-related sequence B that is encoded in the genome of human.


name: TRML2_HUMAN Trem-like transcript 2 protein (sprot)

description: A trem-like transcript 2 protein that is encoded in the genome of human.


name: LIRA6_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 6 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 6 that is encoded in the genome of human.


name: CLC4G_HUMAN C-type lectin domain family 4 member G (sprot)

description: A C-type lectin domain family 4 member G that is encoded in the genome of human.


name: CLM9_HUMAN CMRF35-like molecule 9 (sprot)

description: A CMRF35-like molecule 9 that is encoded in the genome of human.


name: TRML4_HUMAN Trem-like transcript 4 protein (sprot)

description: A trem-like transcript 4 protein that is encoded in the genome of human.


name: CLM5_HUMAN CMRF35-like molecule 5 (sprot)

description: A CMRF35-like molecule 5 that is encoded in the genome of human.


name: TRML1_HUMAN Trem-like transcript 1 protein (sprot)

description: A trem-like transcript 1 protein that is encoded in the genome of human.


name: GLCM1_HUMAN Putative glycosylation-dependent cell adhesion molecule 1 (sprot)


name: PIANP_HUMAN PILR alpha-associated neural protein (sprot)

description: A PILR alpha-associated neural protein that is encoded in the genome of human.


name: LIRA2_HUMAN Leukocyte immunoglobulin-like receptor subfamily A member 2 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily A member 2 that is encoded in the genome of human.


name: LIRB4_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 4 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 4 that is encoded in the genome of human.


name: LIRB1_HUMAN Leukocyte immunoglobulin-like receptor subfamily B member 1 (sprot)

description: A leukocyte immunoglobulin-like receptor subfamily B member 1 that is encoded in the genome of human.


name: RAE1E_HUMAN Retinoic acid early transcript 1E (sprot)

description: A retinoic acid early transcript 1E that is encoded in the genome of human.


name: CLM1_HUMAN CMRF35-like molecule 1 (sprot)

description: A CMRF35-like molecule 1 that is encoded in the genome of human.


name: SIG10_HUMAN Sialic acid-binding Ig-like lectin 10 (sprot)

description: A sialic acid-binding Ig-like lectin 10 that is encoded in the genome of human.


name: SIG12_HUMAN Sialic acid-binding Ig-like lectin 12 (sprot)

description: A sialic acid-binding Ig-like lectin 12 that is encoded in the genome of human.


name: SIG11_HUMAN Sialic acid-binding Ig-like lectin 11 (sprot)

description: A sialic acid-binding Ig-like lectin 11 that is encoded in the genome of human.


name: ULBP3_HUMAN UL16-binding protein 3 (sprot)

description: A UL16-binding protein 3 that is encoded in the genome of human.


name: NPDC1_HUMAN Neural proliferation differentiation and control protein 1 (sprot)

description: A neural proliferation differentiation and control protein 1 that is encoded in the genome of human.


name: SIGL8_HUMAN Sialic acid-binding Ig-like lectin 8 (sprot)

description: A sialic acid-binding Ig-like lectin 8 that is encoded in the genome of human.


name: PILRB_HUMAN Paired immunoglobulin-like type 2 receptor beta (sprot)

description: A paired immunoglobulin-like type 2 receptor beta that is encoded in the genome of human.


name: SIGL7_HUMAN Sialic acid-binding Ig-like lectin 7 (sprot)

description: A sialic acid-binding Ig-like lectin 7 that is encoded in the genome of human.


seryl-tRNA aminoacylation

description: The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.


An organic anionic group obtained by deprotonation of the free phosphate OH group of 5-(2-methoxy-2-oxoethyl)uridine residue.


An organic anionic group obtained by deprotonation of the free phosphate OH group of N(2),N(2)-dimethylguanosine 5'-phosphate residue.


inosine 5'-phosphate(1-) residue

An organic anionic group obtained by deprotonation of the phosphate function of inosine 5'-phosphate residue; major species at 7.3.


pseudouridine 5'-phosphate(1-) residue

An organic anionic group arising from the deprotonation of the phosphate OH group of pseudouridine 5'-phosphate residue.


name: positive regulation of potassium ion export across plasma membrane

description: Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane.


intestinal epithelial cell migration

description: The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.


name: negative regulation of growth hormone secretion

description: Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.


name: negative regulation of cell adhesion mediated by integrin

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin.


name: EPHA2_MOUSE Ephrin type-A receptor 2 (sprot)

description: An ephrin type-A receptor 2 that is encoded in the genome of mouse.


name: EPHA3_MOUSE Ephrin type-A receptor 3 (sprot)

description: An ephrin type-A receptor 3 that is encoded in the genome of mouse.


name: EPHA8_MOUSE Ephrin type-A receptor 8 (sprot)

description: An ephrin type-A receptor 8 that is encoded in the genome of mouse.


name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 (mouse)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 that is encoded in the genome of mouse.


name: negative regulation of translation in response to endoplasmic reticulum stress

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


cardiac right atrium morphogenesis

description: The process in which the right cardiac atrium is generated and organized.


name: negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis.


name: agglutination involved in conjugation with cellular fusion

description: The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae.


name: positive regulation of DNA-templated DNA replication

description: Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication.


histone methyltransferase binding

description: Binding to a histone methyltransferase enzyme.


name: KMT2D_MOUSE Histone-lysine N-methyltransferase 2D (sprot)

description: A histone-lysine N-methyltransferase 2D that is encoded in the genome of mouse.


name: KMT2C_MOUSE Histone-lysine N-methyltransferase 2C (sprot)

description: A histone-lysine N-methyltransferase 2C that is encoded in the genome of mouse.


name: histone H2AR3 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H2A.


peptidyl-arginine N-methylation

description: The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein.


trophoblast giant cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua.


sebum secreting cell proliferation

description: The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum.


transcription factor TFIIA complex

description: A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).


ISWI-type complex

description: Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair.


monoatomic ion channel complex

description: A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient.


poly-purine tract binding

description: Binding to a stretch of purines (adenine or guanine) in an RNA molecule.


name: intraciliary transport particle A binding

description: Binding to an intraciliary transport particle A (IFT A) complex.


N-formylglutamate deformylase activity

description: Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate.


lipid glycosylation

description: Covalent attachment of a glycosyl residue to a lipid molecule.


spermatocyte division

description: The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids.


name: negative regulation of motor neuron apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.


name: cellular response to progesterone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.


name: positive regulation of membrane potential

description: Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


vesicle-mediated cholesterol transport

description: The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles.


protein targeting to ER

description: The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.


sphingolipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


musculoskeletal movement

description: The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.


thymidine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.


name: DNA synthesis involved in mitotic DNA replication

description: Any DNA biosynthetic process that is involved in mitotic DNA replication.


PTTG1_HUMAN Securin (sprot)

A securin that is encoded in the genome of human.


name: E2F3_HUMAN Transcription factor E2F3 (sprot)

description: A transcription factor E2F3 that is encoded in the genome of human.


protein homotetramerization

description: The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.


name: COPRS_HUMAN Coordinator of PRMT5 and differentiation stimulator (sprot)

description: A coordinator of PRMT5 and differentiation stimulator that is encoded in the genome of human.


name: positive regulation of nucleosome disassembly

description: Any process that activates or increases the frequency, rate or extent of the controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.


chondrocyte morphogenesis

description: The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte.


name: establishment of protein localization to vacuole

description: The directed movement of a protein to a specific location in a vacuole.


regulation of viral genome replication

description: Any process that modulates the frequency, rate or extent of viral genome replication.


interferon receptor activity

description: Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


malate dehydrogenase activity

description: Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.


malate metabolic process

description: The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.


urate metabolic process

description: The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.


description: Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.


name: glycerol biosynthetic process from pyruvate

description: The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate.


post-embryonic hemopoiesis

description: The stages of blood cell formation that take place after completion of embryonic development.


name: regulation of signaling receptor activity

description: Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.


regulation of protein catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


name: regulation of protein autophosphorylation

description: Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.


hexose mediated signaling

description: The series of molecular signals mediated by the detection of hexose.


name: regulation of intracellular protein transport

description: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.


description: The removal of the ubiquitin group from a monoubiquitinated protein.


name: ROBO1_HUMAN Roundabout homolog 1 (sprot)

description: A roundabout homolog 1 that is encoded in the genome of human.


name: UCHL5_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L5 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase isozyme L5 that is encoded in the genome of human.


name: UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase isozyme L1 that is encoded in the genome of human.


actin cortical patch localization

description: Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.


name: positive regulation of Arp2/3 complex-mediated actin nucleation

description: Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation.


name: PK3CB_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (sprot)

description: A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human.


name: U119A_HUMAN Protein unc-119 homolog A (sprot)

description: A protein unc-119 homolog A that is encoded in the genome of human.


name: negative regulation of hepatic stellate cell activation

description: Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation.


amacrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.


name: negative regulation of multicellular organism growth

description: Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.


inositol phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


inner cell mass cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.


name: negative regulation of potassium ion export across plasma membrane

description: Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane.


positive regulation of T cell migration

description: Any process that activates or increases the frequency, rate or extent of T cell migration.


negative regulation of myoblast fusion

description: Any process that stops, prevents or reduces the frequency, rate or extent of myoblast fusion.


regulation of mitochondrial fission

description: Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


name: negative regulation of mesenchymal stem cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation.


name: RHOJ_MOUSE Rho-related GTP-binding protein RhoJ (sprot)

description: A Rho-related GTP-binding protein RhoJ that is encoded in the genome of mouse.


name: neuroepithelial cell-transforming gene 1 protein isoform 1 (mouse)

description: A neuroepithelial cell-transforming gene 1 protein isoform 1 that is encoded in the genome of mouse.


name: establishment of meiotic sister chromatid cohesion

description: The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle.


tRNA gene clustering

description: The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae.


name: establishment of mitotic sister chromatid cohesion

description: The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle.


name: cilium assembly protein DZIP1 isoform m1 unphosphorylated 1 (mouse)

description: A cilium assembly protein DZIP1 isoform m1 (mouse) that lacks phosphorylation at the position equivalent to Ser-210. UniProtKB:Q8BMD2-1, Ser-210, PR:000026291.


name: meiotic recombination initiation complex

description: A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins.


geranyl diphosphate(3-)

Trianion of geranyl diphosphate arising from deprotonation of the three OH groups of the diphosphate; major species at pH 7.3.


name: farnesyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.


A 3beta-sterol that is  zymosterol substituted by a 4alpha-methyl group.


fecosterol

A 3beta-sterol having a 5alpha-ergostane skeleton with a methylidene group at C-24 and double bonds at the C-8 and C-24(28) positions.


isoprenoid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


dimethylallyl diphosphate

Trianion of prenyl diphosphate arising from deprotonation of the three diphosphate OH groups.


name: farnesyl diphosphate biosynthetic process, mevalonate pathway

description: The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.


name: isopentenyl diphosphate biosynthetic process, mevalonate pathway

description: The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.


ERGOSTEROL

A phytosterol consisting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group.


A steroid acid anion that is the conjugate base of 4-carboxyzymosterol, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A steroid acid anion that is the conjugate base of 4beta-methylzymosterol-4alpha-carboxylic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A 3beta-sterol having double bonds in the 5-, 7- and 22-positions and a methylene group at position 24.


A 3beta-sterol having double bonds in the 5- and 7-positions and a methylene group at position 24.


A cholestanoid that is 5alpha-cholestane substituted by a beta-hydroxy group at position 3.


A cholestanoid that is (5alpha)-cholest-7-ene substituted by a beta-hydroxy group at position 3.


A 3beta-sterol having the structure of desmosterol with an extra double bond at C-7--C-8.


malonyl-CoA decarboxylase activity

description: Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2.


organic acid phosphorylation

description: The process of introducing one or more phosphate groups into an organic acid.


fatty acid transmembrane transport

description: The process in which a fatty acid is transported across a membrane.


name: ATP:ADP antiporter activity

description: Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out).


ADP transport

description: The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


anaerobic respiration

description: The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.


name: phosphodiesterase decapping endonuclease activity

description: Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA.


mRNA 5'-diphosphatase activity

description: Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end.


name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


name: deadenylation-independent decapping of nuclear-transcribed mRNA

description: Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening.


NAD+ diphosphatase activity

description: Catalysis of the reaction: NAD+ + H2O = AMP + NMN.


NADH metabolic process

description: The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.


description: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.


name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity

description: Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA.


name: positive regulation of translation in response to stress

description: Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.


name: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

description: Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay.


APOA5_HUMAN Apolipoprotein A-V (sprot)

An apolipoprotein A-V that is encoded in the genome of human.


name: CRERF_HUMAN CREB3 regulatory factor (sprot)

description: A CREB3 regulatory factor that is encoded in the genome of human.


APOC2_HUMAN Apolipoprotein C-II (sprot)

An apolipoprotein C-II that is encoded in the genome of human.


name: lipid transferase CIDEC isoform h1 (human)

description: A lipid transferase CIDEC (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96AQ7-1.


name: FGF21_HUMAN Fibroblast growth factor 21 (sprot)

description: A fibroblast growth factor 21 that is encoded in the genome of human.


nuclear lamina

description: The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.


potassium ion leak channel activity

description: Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.


name: Kelch-containing formin regulatory complex

description: A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p.


name: regulation of formin-nucleated actin cable assembly

description: Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


cytogamy

description: During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.


name: mating-type alpha-factor pheromone receptor activity

description: Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity.


name: positive regulation of receptor internalization

description: Any process that activates or increases the frequency, rate or extent of receptor internalization.


phospho sugar

Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid.


name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity

description: Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+.


regulation of response to stress

description: Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


dermal bone morphogenesis

description: The process in which bone which forms superficially in the organism are generated and organized.


FFAT motif binding

description: Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.


endoplasmic reticulum polarization

description: The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. Endoplasmic reticulum polarization serves as a mechanism to compartmentalize cellular activities and to establish cell polarity.


name: regulation of intracellular lipid transport

description: Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.


maintenance of cell polarity

description: The maintenance of established anisotropic intracellular organization or cell growth patterns.


actin cytoskeleton-regulatory complex

description: A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat.


Arp2/3 complex binding

description: Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).


future telencephalon

description: Embryonic structure that gives rise to the telencephalon.


central nervous system segmentation

description: Division of the central nervous system into a series of semi-repetitive parts or segments.


growth factor binding

description: Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.


name: post-embryonic camera-type eye morphogenesis

description: The process in which the anatomical structures of the eye are generated and organized during post-embryonic development.


name: positive regulation of mitochondrial depolarization

description: Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.


name: VEGFA_MOUSE Vascular endothelial growth factor A, long form (sprot)

description: A vascular endothelial growth factor A, long form that is encoded in the genome of mouse.


name: positive regulation of systemic arterial blood pressure

description: The process that increases the force with which blood travels through the systemic arterial circulatory system.


name: promoter-enhancer loop anchoring activity

description: Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop.


name: negative regulation of male germ cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation.


cell-cell adhesion mediated by cadherin

description: The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.


name: positive regulation of cytokine production involved in immune response

description: Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.


chondroblast differentiation

description: The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.


optic nerve morphogenesis

description: The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


sagittal suture morphogenesis

description: The process in which the sagittal suture is generated and organized.


anterior semicircular canal development

description: The progession of the anterior semicircular canal from its initial formation to the mature structure.


lateral semicircular canal development

description: The progession of the lateral semicircular canal from its initial formation to the mature structure.


lambdoid suture morphogenesis

description: The process in which the lambdoid suture is generated and organized.


name: substantia propria of cornea development

description: The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure.


name: intronic transcription regulatory region sequence-specific DNA binding

description: Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within.


menarche

description: The beginning of the menstrual cycle; the first menstrual cycle in an individual.


developmental induction

description: A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).


globus pallidus development

description: The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain.


Cul4B-RING E3 ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.


name: TBPL2_HUMAN TATA box-binding protein-like 2 (sprot)

description: A TATA box-binding protein-like 2 that is encoded in the genome of human.


name: TCF7_HUMAN Transcription factor 7 (sprot)

description: A transcription factor 7 that is encoded in the genome of human.


pulmonary myocardium development

description: The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.


atrioventricular node cell development

description: The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state.


name: atrioventricular node cell fate commitment

description: The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells.


IgG binding

description: Binding to an immunoglobulin of an IgG isotype.


name: negative regulation of inflammatory response to antigenic stimulus

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.


name: negative regulation of acute inflammatory response to antigenic stimulus

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.


name: negative regulation of type I hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.


aggressive behavior

description: A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.


phosphate ion transport

description: The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Seh1-associated complex

description: A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.


name: negative regulation of small GTPase mediated signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.


name: negative regulation of pre-miRNA processing

description: Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing.


name: positive regulation of pre-miRNA processing

description: Any process that activates or increases the frequency, rate or extent of pre-microRNA processing.


name: TRUB1_HUMAN Pseudouridylate synthase TRUB1 (sprot)

description: A pseudouridylate synthase TRUB1 that is encoded in the genome of human.


name: DDX21_HUMAN Nucleolar RNA helicase 2 (sprot)

description: A nucleolar RNA helicase 2 that is encoded in the genome of human.


name: BAZ1B_HUMAN Tyrosine-protein kinase BAZ1B (sprot)

description: A bromodomain adjacent to zinc finger domain protein 1B that is encoded in the genome of human.


name: MBB1A_HUMAN Myb-binding protein 1A (sprot)

description: A Myb-binding protein 1A that is encoded in the genome of human.


name: regulation of sodium ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport.


name: negative regulation of pancreatic juice secretion

description: Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


aldosterone secretion

description: The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


pre-mRNA intronic binding

description: Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA).


trachea cartilage development

description: The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.