phosphatidylcholine flippase activity

description: Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


amino acid sensor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to and responding, e.g. by conformational change, to changes in the cellular level of an amino acid.


L-cysteine binding

description: Binding to L-cysteine.


cellular response to L-arginine

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.


protein targeting to vacuole

description: The process of directing proteins towards the vacuole, usually using signals contained within the protein.


vacuolar transport

description: The directed movement of substances into, out of or within a vacuole.


peroxisome fission

description: The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.


lipid tube assembly

description: The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission.


misfolded protein transport

description: The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.


lipid phosphatase activity

description: Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.


myeloid cell development

description: The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.


lifelong otolith mineralization

description: The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added.


name: myeloid cell activation involved in immune response

description: A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.


name: oxidoreductase activity, acting on iron-sulfur proteins as donors

description: Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


name: tRNA uridine(34) acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H+ + L-methionine.


name: positive regulation of formin-nucleated actin cable assembly

description: Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


free ubiquitin chain depolymerization

description: The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down.


spinal cord patterning

description: The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord.


name: immune response-regulating cell surface receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.


RS domain binding

description: Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.


B cell costimulation

description: The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.


name: positive regulation of eosinophil migration

description: Any process that activates or increases the frequency, rate or extent of eosinophil migration.


name: I17RE_HUMAN Interleukin-17 receptor E (sprot)

description: An interleukin-17 receptor E that is encoded in the genome of human.


name: I17RB_HUMAN Interleukin-17 receptor B (sprot)

description: An interleukin-17 receptor B that is encoded in the genome of human.


name: IRPL1_HUMAN Interleukin-1 receptor accessory protein-like 1 (sprot)

description: An interleukin-1 receptor accessory protein-like 1 that is encoded in the genome of human.


name: IL1FA_HUMAN Interleukin-1 family member 10 (sprot)

description: An interleukin-1 family member 10 that is encoded in the genome of human.


name: ILRL2_HUMAN Interleukin-1 receptor-like 2 (sprot)

description: An interleukin-1 receptor-like 2 that is encoded in the genome of human.


interleukin-17E receptor binding

description: Binding to an interleukin-17E receptor.


response to fungus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.


mitotic DNA replication termination

description: Any DNA replication termination involved in mitotic cell cycle DNA replication.


name: positive regulation of mast cell degranulation

description: Any process that activates or increases the frequency, rate or extent of mast cell degranulation.


mechanosensory behavior

description: Behavior that is dependent upon the sensation of a mechanical stimulus.


name: positive regulation of interleukin-5 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.


name: positive regulation of interleukin-13 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.


prostate gland epithelium morphogenesis

description: The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.


compartment pattern specification

description: The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation.


name: positive regulation of aorta morphogenesis

description: Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.


name: apoptotic process involved in embryonic digit morphogenesis

description: Any apoptotic process that is involved in embryonic digit morphogenesis.


auditory receptor cell fate commitment

description: The process in which the cellular identity of auditory hair cells is acquired and determined.


foregut morphogenesis

description: The process in which the anatomical structures of the foregut are generated and organized.


name: regulation of epithelial cell proliferation involved in prostate gland development

description: Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


RNA decapping

description: Cleavage of the 5'-cap of an RNA.


RNA stem-loop binding

description: Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.


name: regulation of CD4-positive, alpha-beta T cell differentiation

description: Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.


ureter maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


thymic T cell selection

description: The process of T cell selection that occurs in the thymus.


parathyroid hormone secretion

description: The regulated release of parathyroid hormone into the circulatory system.


name: positive regulation of T-helper 2 cell cytokine production

description: Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.


name: IL2RA_MOUSE Interleukin-2 receptor subunit alpha (sprot)

description: An interleukin-2 receptor subunit alpha that is encoded in the genome of mouse.


cell septum

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.


cellulase activity

description: Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.


septum digestion after cytokinesis

description: The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.


description: Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.


eRF1 methyltransferase complex

description: A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.


peptidyl-glutamine methylation

description: The addition of a methyl group to a glutamine residue in a protein.


nucleolar chromatin

description: The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.


ATP-dependent activity, acting on DNA

description: Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.


rDNA binding

description: Binding to a DNA sequence encoding a ribosomal RNA.


name: regulation of transcriptional start site selection at RNA polymerase II promoter

description: Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.


name: negative regulation of DNA-templated DNA replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication.


nucleosome disassembly

description: The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.


oligodendrocyte precursor cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons.


name: positive regulation of deoxyribonuclease activity

description: Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.


cupric reductase activity

description: Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.


CENP-A containing nucleosome

description: A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).


name: sexual sporulation resulting in formation of a cellular spore

description: The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction.


name: global genome nucleotide-excision repair

description: The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome.


peptidyl-arginine methylation

description: The addition of a methyl group to an arginine residue in a protein.


regulation of odontogenesis

description: Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.


name: positive regulation of compound eye pigmentation

description: Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye.


retinol transport

description: The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.


rectus abdominis muscle

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The rectus abdominis muscle is a paired muscle running vertically on each side of the anterior wall of the abdomen. There are two parallel sets of muscles, separated by a midline band of connective tissue called the linea alba (white line). It extends from the pubic symphysis/pubic crest inferiorly to the xiphisternum/xiphoid process and lower costal cartilages (5-7) superiorly. It is contained in the Rectus sheath. The rectus is usually crossed by three fibrous bands licked by the tendinous inscriptions. [WP,modified].


muscle tissue development

description: The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.


lateral line nerve glial cell

description: Any glial cell that is part of some lateral line nerve.


Cdc73/Paf1 complex

description: A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.


name: RNA polymerase II preinitiation complex assembly

description: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.


hard palate morphogenesis

description: The developmental process by which a hard palate is generated and organized.


name: negative regulation of viral genome replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.


name: regulation of transcription elongation by RNA polymerase II

description: Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


name: cellular response to potassium ion starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions.


Golgi medial cisterna membrane

description: The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex.


name: regulation of skeletal muscle tissue regeneration

description: Any process that modulates the frequency, rate or extent of skeletal muscle.


spindle pole body organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome.


name: negative regulation of glycogen catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.


name: positive regulation of glycogen catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.


peptidyl-lysine dimethylation

description: The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.


name: meiotic telomere tethering at nuclear periphery

description: The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle.


karyogamy

description: The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.


secretory vesicle

description: A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.


name: negative regulation of formin-nucleated actin cable assembly

description: Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


name: mitotic morphogenesis checkpoint signaling

description: A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth.


name: positive regulation of G2/M transition of mitotic cell cycle

description: Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


nuclear pore central transport channel

description: The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.


name: mRNA export from nucleus in response to heat stress

description: The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export.


name: protein localization to nuclear inner membrane

description: A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.


name: STRAA_HUMAN STE20-related kinase adapter protein alpha (sprot)

description: A STE20-related kinase adapter protein alpha that is encoded in the genome of human.


name: STRAB_HUMAN STE20-related kinase adapter protein beta (sprot)

description: A STE20-related kinase adapter protein beta that is encoded in the genome of human.


name: CB39L_HUMAN Calcium-binding protein 39-like (sprot)

description: A calcium-binding protein 39-like that is encoded in the genome of human.


cyclin-related protein

A protein that consists of a copy of the Cyclin, N-terminal domain (Pfam:PF00134). This class includes the G1/S cyclins, essential for the control of the cell cycle at the G1/S transition, and the G2/M cyclins, essential for the control of the cell cycle at the G2/M transition.


fatty-acyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.


mating projection membrane

description: The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone.


cellular bud membrane

description: The portion of the plasma membrane surrounding a cellular bud.


name: regulation of fungal-type cell wall organization

description: Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.


eisosome assembly

description: The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane.


name: regulation of phospholipid translocation

description: Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


membrane fusion

description: The membrane organization process that joins two lipid bilayers to form a single membrane.


regulation of membrane invagination

description: Any process that modulates the frequency, rate or extent of membrane invagination.


protein targeting to vacuolar membrane

description: The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein.


voltage-gated proton channel activity

description: Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: F-actin-capping protein subunit beta isoform Capzb3 (mouse)

description: An F-actin-capping protein subunit beta isoform Capzb3 that is encoded in the genome of mouse.


regulation of biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.


name: transcriptional activator GLI3 precursor (mouse)

description: A transcriptional activator GLI3 (mouse) that has not been subjected to any proteolytic cleavage. UniProtKB:Q61602, 1-1583.


transcriptional repressor GLI3R (mouse)

A transcriptional activator GLI3 precursor (mouse) that has been processed by proteolytic cleavage, removing the C-terminal region. UniProtKB:Q61602, 1-?.


actin filament bundle distribution

description: Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell.


positive regulation of blood pressure

description: Any process in which the force of blood traveling through the circulatory system is increased.


drinking behavior

description: The specific behavior of an organism relating to the intake of liquids, especially water.


hormone-mediated signaling pathway

description: The series of molecular signals mediated by the detection of a hormone.


name: renin-angiotensin regulation of aldosterone production

description: The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.


name: regulation of blood volume by renin-angiotensin

description: The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.


name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

description: Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity.


name: negative regulation of glial cell proliferation

description: Any process that stops or decreases the rate or extent of glial cell proliferation.


name: positive regulation of granuloma formation

description: Any process that activates or increases the frequency, rate, or extent of granuloma formation.


regulation of vasculogenesis

description: Any process that modulates the frequency, rate or extent of vasculogenesis.


regulation of peroxisome organization

description: Any process that modulates the frequency, rate or extent of peroxisome organization.


name: DECR2_HUMAN Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (sprot)

description: A peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] that is encoded in the genome of human.


vestibular nucleus development

description: The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.


transport vesicle

description: Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.


name: regulation of voltage-gated sodium channel activity

description: Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity.


adrenergic receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


regulation of transporter activity

description: Any process that modulates the activity of a transporter.


name: cellular response to epinephrine stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.


digestive system process

description: A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


name: membrane repolarization during ventricular cardiac muscle cell action potential

description: The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


name: negative regulation of potassium ion transmembrane transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.


name: negative regulation of gastric acid secretion

description: Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


renal sodium ion transport

description: The directed movement of sodium ions (Na+) by the renal system.


pancreatic ductal cell

description: Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH.


name: negative regulation of hypoxia-inducible factor-1alpha signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway.


pancreatic A cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


name: hypoxia-inducible factor-1alpha signaling pathway

description: The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.


monoatomic anion transport

description: The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom.


name: branching involved in pancreas morphogenesis

description: The process in which the branches of the pancreas are generated and organized.


ovulation from ovarian follicle

description: The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.


name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


zymogen granule

description: A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.


zymogen granule exocytosis

description: The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions.


response to nicotine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.


D-chiro-inositol

Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.


name: positive regulation of prostaglandin secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell.


sodium/iodide cotransporter

A protein that is a translation product of the human SLC5A5 gene or a 1:1 ortholog thereof.


response to epinephrine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.


mating-type region heterochromatin

description: Heterochromatic regions of the chromosome found at silenced mating-type loci.


positive regulation of RNA splicing

description: Any process that activates or increases the frequency, rate or extent of RNA splicing.


name: DNA repair-dependent chromatin remodeling

description: A chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions.


name: regulation of response to reactive oxygen species

description: Any process that modulates the frequency, rate or extent of response to reactive oxygen species.


eisosome membrane domain/MCC

description: A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins.


eukaryotic initiation factor 4G binding

description: Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.


sno(s)RNA processing

description: Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea).


name: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay

description: The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction.


name: protein localization to eisosome filament

description: A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.


name: regulation of nuclear cell cycle DNA replication

description: Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.


cellular response to manganese ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.


stress response to metal ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus.


cerebellum formation

description: The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.


Golgi to endosome transport

description: The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.


regulation of inclusion body assembly

description: Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.


name: protein localization to prospore membrane

description: A process in which a protein is transported to, or maintained in, a location within a prospore membrane.


vesicle fusion to plasma membrane

description: Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.


name: negative regulation of fibroblast migration

description: Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.


contractile muscle fiber

description: Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.


laminin-10 complex

description: A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.


chloride ion binding

description: Binding to a chloride ion (Cl-).


actin filament depolymerization

description: Disassembly of actin filaments by the removal of actin monomers from a filament.


nuclear envelope lumen

description: The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.


ACTB_MOUSE Actin, cytoplasmic 1 (sprot)

An actin, cytoplasmic 1 that is encoded in the genome of mouse.


ACTN3_MOUSE Alpha-actinin-3 (sprot)

An alpha-actinin-3 that is encoded in the genome of mouse.


WASH complex

description: A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.


nerve

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.


description: A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.


fast muscle cell

description: A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron.


adult somatic muscle development

description: The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure.


cell-substrate junction

description: A cell junction that forms a connection between a cell and the extracellular matrix.


myotube cell development

description: The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


name: multicellular organismal reproductive process

description: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.


name: reactive oxygen species biosynthetic process

description: The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.


name: establishment of glial blood-brain barrier

description: Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.


establishment of blood-nerve barrier

description: The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.


olfactory nerve structural organization

description: The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.


granular cell of epidermis

description: A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules.


chorda tympani branch of facial nerve

description: The chorda tympani is a nerve that branches from the facial nerve (cranial nerve VII) inside the facial canal, just before the facial nerve exits the skull via the stylomastoid foramen. Chorda tympani is a branch of the facial nerve (the seventh cranial nerve) that serves the taste buds in the front of the tongue, runs through the middle ear, and carries taste messages to the brain. The chorda tympani is part of one of three cranial nerves that are involved in taste. The taste system involves a complicated feedback loop, with each nerve acting to inhibit the signals of other nerves. The chorda tympani appears to exert a particularly strong inhibitory influence on other taste nerves, as well as on pain fibers in the tongue. When the chorda tympani is damaged, its inhibitory function is disrupted, leading to less inhibited activity in the other nerves.


name: positive regulation of T cell chemotaxis

description: Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.


NECT2_HUMAN Nectin-2 (sprot)

A nectin-2 that is encoded in the genome of human.


afadin isoform h1 (human)

An afadin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55196-2.


CTNA1_HUMAN Catenin alpha-1 (sprot)

A catenin alpha-1 that is encoded in the genome of human.


NECT3_HUMAN Nectin-3 (sprot)

A nectin-3 that is encoded in the genome of human.


NECT1_HUMAN Nectin-1 (sprot)

A nectin-1 that is encoded in the genome of human.


CADH2_HUMAN Cadherin-2 (sprot)

A cadherin-2 that is encoded in the genome of human.


CADH3_HUMAN Cadherin-3 (sprot)

A cadherin-3 that is encoded in the genome of human.


CADH5_HUMAN Cadherin-5 (sprot)

A cadherin-5 that is encoded in the genome of human.


CADH4_HUMAN Cadherin-4 (sprot)

A cadherin-4 that is encoded in the genome of human.


CADH6_HUMAN Cadherin-6 (sprot)

A cadherin-6 that is encoded in the genome of human.


CADH8_HUMAN Cadherin-8 (sprot)

A cadherin-8 that is encoded in the genome of human.


CAD11_HUMAN Cadherin-11 (sprot)

A cadherin-11 that is encoded in the genome of human.


CAD12_HUMAN Cadherin-12 (sprot)

A cadherin-12 that is encoded in the genome of human.


CAD13_HUMAN Cadherin-13 (sprot)

A cadherin-13 that is encoded in the genome of human.


CAD15_HUMAN Cadherin-15 (sprot)

A cadherin-15 that is encoded in the genome of human.


CAD17_HUMAN Cadherin-17 (sprot)

A cadherin-17 that is encoded in the genome of human.


CAD18_HUMAN Cadherin-18 (sprot)

A cadherin-18 that is encoded in the genome of human.


CAD24_HUMAN Cadherin-24 (sprot)

A cadherin-24 that is encoded in the genome of human.


NECT4_HUMAN Nectin-4 (sprot)

A nectin-4 that is encoded in the genome of human.


CADH9_HUMAN Cadherin-9 (sprot)

A cadherin-9 that is encoded in the genome of human.


CADH7_HUMAN Cadherin-7 (sprot)

A cadherin-7 that is encoded in the genome of human.


CAD10_HUMAN Cadherin-10 (sprot)

A cadherin-10 that is encoded in the genome of human.


dystroglycan complex

description: A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.


regular cardiac myocyte

description: A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval.


name: retrograde trans-synaptic signaling by trans-synaptic protein complex

description: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.


morphogenesis of an epithelial sheet

description: The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.


negative regulation of cell motility

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.


keratohyalin granule

description: A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope.


name: pigment metabolic process involved in developmental pigmentation

description: The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism.


name: chymotrypsin-like elastase family member 2A, mature form (mouse)

description: A chymotrypsin-like elastase family member 2A, pro-form (mouse) that has had the activation peptide removed by proteolytic cleavage. UniProtKB:P05208, 31-271.


DNA biosynthetic process

description: The biosynthetic process resulting in the formation of DNA.


oncogene-induced cell senescence

description: A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family.


name: protein localization involved in establishment of planar polarity

description: Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity.


name: positive regulation of tumor necrosis factor-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway.


name: positive regulation of chemokine (C-C motif) ligand 20 production

description: Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production.


name: positive regulation of interleukin-17-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway.


name: structural constituent of skin epidermis

description: The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure.


desmosome assembly

description: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


striated muscle thin filament

description: Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.


name: LIM domain-binding protein 3 isoform 6 (mouse)

description: A LIM domain-binding protein 3 isoform 6 that is encoded in the genome of mouse.


name: LIM domain-binding protein 3 isoform 1 (mouse)

description: A LIM domain-binding protein 3 isoform 1 that is encoded in the genome of mouse.


name: polyamine transmembrane transporter activity

description: Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other.


SUMO ligase regulator activity

description: Binds to and modulates the activity of a SUMO ligase.


Y-form DNA binding

description: Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.


flap-structured DNA binding

description: Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule.


name: VPS16_HUMAN Vacuolar protein sorting-associated protein 16 homolog (sprot)

description: A vacuolar protein sorting-associated protein 16 that is encoded in the genome of human.


name: VPS11_HUMAN Vacuolar protein sorting-associated protein 11 homolog (sprot)

description: A vacuolar protein sorting-associated protein 11 that is encoded in the genome of human.


name: VPS41_HUMAN Vacuolar protein sorting-associated protein 41 homolog (sprot)

description: A vacuolar protein sorting-associated protein 41 that is encoded in the genome of human.


name: VP33A_HUMAN Vacuolar protein sorting-associated protein 33A (sprot)

description: A vacuolar protein sorting-associated protein 33A that is encoded in the genome of human.


name: VPS18_HUMAN Vacuolar protein sorting-associated protein 18 homolog (sprot)

description: A vacuolar protein sorting-associated protein 18 that is encoded in the genome of human.


mitochondrial protein processing

description: The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.


name: peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion

description: The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion.


cellular response to glutathione

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus.


transport vesicle membrane

description: The lipid bilayer surrounding a transport vesicle.


OPT_HUMAN Opticin (sprot)

An opticin that is encoded in the genome of human.


name: SCUB3_HUMAN Signal peptide, CUB and EGF-like domain-containing protein 3 (sprot)

description: A signal peptide, CUB and EGF-like domain-containing protein 3 that is encoded in the genome of human.


name: IBP4_HUMAN Insulin-like growth factor-binding protein 4 (sprot)

description: An insulin-like growth factor-binding protein 4 that is encoded in the genome of human.


name: IBP5_HUMAN Insulin-like growth factor-binding protein 5 (sprot)

description: An insulin-like growth factor-binding protein 5 that is encoded in the genome of human.


name: ECE2_HUMAN Endothelin-converting enzyme 2 (sprot)

description: An endothelin-converting enzyme 2 that is encoded in the genome of human.


female somatic sex determination

description: The determination of sex and sexual phenotypes in a female organism's soma.


skeletal muscle organ development

description: The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.


name: regulation of cardiac muscle fiber development

description: Any process that modulates the frequency, rate or extent of cardiac muscle fiber development.


name: cardiac muscle myosin thick filament assembly

description: The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle.


Wnt-Frizzled-LRP5/6 complex

description: A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6.


DNA-templated transcription elongation

description: The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.


DNA-templated transcription termination

description: The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.


name: negative regulation of antisense RNA transcription

description: Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA.


Set1C/COMPASS complex

description: A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.


name: regulation of meiotic DNA double-strand break formation

description: Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation.


name: meiotic DNA double-strand break formation

description: The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.


mRNA cleavage factor complex

description: Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.


nuclear pore localization

description: Any process in which nuclear pores are transported to, or maintained in, a specific location.


name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

description: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.


name: regulation of mRNA export from nucleus in response to heat stress

description: Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress.


name: regulation of endoplasmic reticulum unfolded protein response

description: Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


response to singlet oxygen

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.


sterol transfer activity

description: Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.


sterol binding

description: Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.


intracellular sterol transport

description: The directed movement of sterols within cells.


GMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.


'de novo' XMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors.


purine nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


adenosine 5'-monophosphate

A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase.


adenine metabolic process

description: The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


name: HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase (sprot)

description: A hypoxanthine-guanine phosphoribosyltransferase that is encoded in the genome of human.


AMPD1_HUMAN AMP deaminase 1 (sprot)

An AMP deaminase 1 that is encoded in the genome of human.


AMPD2_HUMAN AMP deaminase 2 (sprot)

An AMP deaminase 2 that is encoded in the genome of human.


GMP synthase activity

description: Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+.


'de novo' IMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.


'de novo' AMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).


AMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.


purine nucleotide salvage

description: Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis.


purine nucleotide metabolic process

description: The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: PUR8_HUMAN Adenylosuccinate lyase (sprot)

description: An adenylosuccinate lyase that is encoded in the genome of human.


AMP binding

description: Binding to AMP, adenosine monophosphate.


adenine binding

description: Binding to adenine, a purine base.


GMPR1_HUMAN GMP reductase 1 (sprot)

A GMP reductase 1 that is encoded in the genome of human.


GMPR2_HUMAN GMP reductase 2 (sprot)

A GMP reductase 2 that is encoded in the genome of human.


name: negative regulation of exit from mitosis

description: Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).


MAP-kinase scaffold activity

description: The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.


name: MAP kinase serine/threonine phosphatase activity

description: Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate.


positive regulation of phosphorylation

description: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.


name: negative regulation of ergosterol biosynthetic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.


name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion

description: In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.


name: negative regulation of cell wall integrity MAPK cascade

description: Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis.


name: signal transduction involved in filamentous growth

description: Relaying of environmental signals promoting filamentous growth.


cell wall integrity MAPK cascade

description: A MAPK cascade containing at least the SLT2 (S.cerevisiae)/Pmk1 (S.pombe) MAP kinase. It starts with the activation of an upstream MAP4K, and continues with the consecutive activation of a MAP3K and a MAP2K. The upstream MAP4K is activated following the detection of stretching of the plasma membrane or alterations of its connections to the cell wall by membrane sensors.


SAM domain binding

description: Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes.


histone H2BS14 kinase activity

description: Catalysis of the reaction: histone H2B-serine (position 14) + ATP = histone H2B-phosphoserine (position 14) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 14 of histone H2B.


budding cell apical bud growth

description: Growth at the tip of a bud, in a cell that reproduces by budding.


bipolar cellular bud site selection

description: The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell.


sterol import

description: The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


regulation of hemopoiesis

description: Any process that modulates the frequency, rate or extent of hemopoiesis.


chromatin loop anchoring activity

description: Bridging together two DNA loop anchors together, maintaining a chromatin loop.


thiol oxidase activity

description: Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2.


name: regulation of protein folding in endoplasmic reticulum

description: Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).


protein alpha-1,2-demannosylation

description: The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein.


cerebellar granular layer development

description: The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


ATP transport

description: The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


xenobiotic transmembrane transport

description: The process in which a xenobiotic, a compound foreign to the organism exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


histone arginine deiminase activity

description: Catalysis of the reaction: H2O + histone 3 L-arginyl = histone 3 L-citrullyl + NH4+, resulting in histone citrullination.


nuclear RNA export factor complex

description: A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm.


name: osmosensory signaling via phosphorelay pathway

description: The series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. In S.cerevisiae, the osmosensor is the histidine kinase Sln1.


name: phosphorelay response regulator activity

description: Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.


name: synaptosomal-associated protein 25 isoform 2 (mouse)

description: A synaptosomal-associated protein 25 isoform 2 that is encoded in the genome of mouse.


name: epithelial to mesenchymal transition involved in endocardial cushion formation

description: A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.


name: positive regulation of mitotic nuclear division

description: Any process that activates or increases the frequency, rate or extent of mitosis.


larynx morphogenesis

description: The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.


name: negative regulation of synapse maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.


hypoblast (generic)

description: Missing definition for term UBERON:0000089. Please replace it using linked reference.


syndecan binding

description: Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.


type A cell of stomach

description: A type of enteroendocrine cell found in the stomach that secretes glucagon.


transforming growth factor beta binding

description: Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.


synaptic vesicle cycle

description: A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.


laminin-1 binding

description: Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.


prostate gland development

description: The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.


salivary gland cavitation

description: The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland.


name: negative regulation of mesenchymal cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.


striated muscle tissue development

description: The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.


prostate epithelial cord elongation

description: The developmental growth process in which solid chords of prostate epithelium increase in length.


name: positive regulation of cerebellar granule cell precursor proliferation

description: The process that activates or increases the rate or extent of granule cell precursor proliferation.


regulation of proteolysis

description: Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


name: positive regulation of skeletal muscle cell proliferation

description: Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.


regulation of prostatic bud formation

description: Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.


name: mesenchymal smoothened signaling pathway involved in prostate gland development

description: The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development.


tracheoesophageal septum formation

description: The process that gives rise to the tracheoesophageal septum. This process pertains to the initial formation of a structure from unspecified parts.


name: cell proliferation in external granule layer

description: The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere.


name: regulation of mesenchymal cell proliferation involved in prostate gland development

description: Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


left lung development

description: The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.


primary prostatic bud elongation

description: The increase in size of the prostatic bud as it forms.


name: negative regulation of alpha-beta T cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation.


skeletal muscle cell proliferation

description: The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.


name: mesenchymal cell proliferation involved in prostate gland development

description: The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time.


right lung development

description: The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect.


ligand-gated channel activity

description: Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


membrane microdomain

description: A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it.


hippocampus stratum oriens

description: Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995).


name: NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)

description: A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.


diencephalon

description: The division of the forebrain that develops from the foremost primary cerebral vesicle.


name: 5HT1B_CRIGR 5-hydroxytryptamine receptor 1B (sprot)


name: H0UVT3_CAVPO ATP binding cassette subfamily C member 8 (trembl)


pharynx development

description: The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.


conjugation with cellular fusion

description: A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.


structural constituent of cell wall

description: The action of a molecule that contributes to the structural integrity of a cell wall.


name: positive regulation of activin receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway.


name: negative regulation of microglial cell activation

description: Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation.


cytoplasmic side of membrane

description: The side of a membrane that faces the cytoplasm.


name: deadenylation-dependent decapping of nuclear-transcribed mRNA

description: Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.


name: negative regulation of translational elongation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.


filamentous growth

description: The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.


name: positive regulation of type III interferon production

description: Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.


name: facio-acoustic VII-VIII preganglion complex


serum response element binding

description: Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.


name: positive regulation of transforming growth factor beta2 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2.


name: regulation of growth plate cartilage chondrocyte proliferation

description: Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


name: negative regulation of interleukin-12 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.


cellular response to dsRNA

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.


name: positive regulation of vascular associated smooth muscle cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.


name: positive regulation of biomineral tissue development

description: Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.


name: protein localization to tricellular tight junction

description: A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction.


name: appetite-regulating hormone isoform 1 cleaved and non-octanoylated 1 (mouse)

description: An appetite-regulating hormone isoform 1 cleaved and non-octanoylated 1 in mouse. UniProtKB:Q9EQX0-1, 24-51, Ser-26, PR:000026291.


name: BH3-interacting domain death agonist isoform 4 (human)

description: A BH3-interacting domain death agonist isoform 4 that is encoded in the genome of human.


name: positive regulation of release of cytochrome c from mitochondria

description: Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.


name: response to transforming growth factor beta

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.


immune system development

description: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.


paraxial mesoderm morphogenesis

description: The process in which the anatomical structures of the paraxial mesoderm are generated and organized.


name: structural constituent of postsynaptic intermediate filament cytoskeleton

description: The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.


morphogenesis of a branching epithelium

description: The process in which the anatomical structures of a branched epithelium are generated and organized.


name: NFYC_HUMAN Nuclear transcription factor Y subunit gamma (sprot)

description: A nuclear transcription factor Y subunit gamma that is encoded in the genome of human.


name: NFYA_HUMAN Nuclear transcription factor Y subunit alpha (sprot)

description: A nuclear transcription factor Y subunit alpha that is encoded in the genome of human.


name: NFYB_HUMAN Nuclear transcription factor Y subunit beta (sprot)

description: A nuclear transcription factor Y subunit beta that is encoded in the genome of human.


name: regulation of protein homodimerization activity

description: Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.


cholangiocyte proliferation

description: The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.


poly(U) RNA binding

description: Binding to a sequence of uracil residues in an RNA molecule.


name: negative regulation of lysosomal protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.


nucleotide salvage

description: Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis.


DCK_HUMAN Deoxycytidine kinase (sprot)

A deoxycytidine kinase that is encoded in the genome of human.


name: fungal-type cell wall organization or biogenesis

description: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall.


name: negative regulation of mesoderm development

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.


ascospore wall

description: The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi.


fungal-type cell wall biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.


name: positive regulation of division septum assembly

description: Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.


regulation of proteasome assembly

description: Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex.


regulation of flocculation

description: Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms.


name: negative regulation of protein kinase C signaling

description: Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


Tr1 cell

description: CD4-positive alpha-beta T cell with regulatory function that produces IL-10.


name: TSC22 domain family protein 1 isoform 1 (mouse)

description: A TSC22 domain family protein 1 isoform 1 that is encoded in the genome of mouse.


name: RARB_MOUSE Retinoic acid receptor beta (sprot)

description: A retinoic acid receptor beta that is encoded in the genome of mouse.


regulation of sporulation

description: Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.


name: ubiquinone biosynthetic process from tyrosine

description: The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate.


description: Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+.


carboxylate reductase activity

description: Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor.


aldehyde catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.


regulation of exocyst localization

description: Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


name: regulation of vacuole fusion, non-autophagic

description: Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole.


budding cell isotropic bud growth

description: Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding.


name: regulation of protein localization to cell division site

description: Any process that modulates the frequency, rate or extent of protein localization to cell division site.


regulation of lysosome size

description: Any process that modulates the size of a lysosome.


name: negative regulation of glucose mediated signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway.


name: negative regulation of translational frameshifting

description: Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting.


preribosome, small subunit precursor

description: A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.


name: SC23B_HUMAN Protein transport protein Sec23B (sprot)

description: A protein transport protein Sec23B that is encoded in the genome of human.


name: AAMP_HUMAN Angio-associated migratory cell protein (sprot)

description: An angio-associated migratory cell protein that is encoded in the genome of human.


homologous recombination

description: A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules.


name: negative regulation of melanocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation.


name: negative regulation of vascular endothelial growth factor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway.


photoreceptor cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.


name: PUR9_HUMAN Bifunctional purine biosynthesis protein ATIC (sprot)

description: A bifunctional purine biosynthesis protein ATIC that is encoded in the genome of human.


name: PUR6_HUMAN Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (sprot)

description: A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase that is encoded in the genome of human.


name: PURA2_HUMAN Adenylosuccinate synthetase isozyme 2 (sprot)

description: An adenylosuccinate synthetase isozyme 2 that is encoded in the genome of human.


name: negative regulation of cellular senescence

description: Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.


heart rudiment morphogenesis

description: The process in which the anatomical structures of the heart rudiment are generated and organized.


name: cell migration involved in heart jogging

description: The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging.


regulation of cilium movement

description: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.


UTP binding

description: Binding to UTP, uridine 5'-triphosphate.


'de novo' UMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen.


name: 'de novo' pyrimidine nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.


name: pyruvate dehydrogenase (acetyl-transferring) activity

description: Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.


peptidyl-serine dephosphorylation

description: The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine.


name: TNR22_MOUSE Tumor necrosis factor receptor superfamily member 22 (sprot)

description: A tumor necrosis factor receptor superfamily member 22 that is encoded in the genome of mouse.


name: TNR23_MOUSE Tumor necrosis factor receptor superfamily member 23 (sprot)

description: A tumor necrosis factor receptor superfamily member 23 that is encoded in the genome of mouse.


name: regulation of type B pancreatic cell apoptotic process

description: Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process.


budding cell bud growth

description: The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.


protein localization to septin ring

description: A process in which a protein is transported to, or maintained in, a location within a septin ring.


maltose metabolic process

description: The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch.


name: UCK2_HUMAN Uridine-cytidine kinase 2 (sprot)

description: A uridine-cytidine kinase 2 that is encoded in the genome of human.


1,2-diacyl-sn-glycerol 3-phosphate(2-)

The conjugate base of a 1,2-diacyl-sn-glycerol 3-phosphate compound.


name: serine/threonine-protein kinase mTOR isoform 1 phosphorylated 1 (mouse)

description: A serine/threonine-protein kinase mTOR isoform 1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-2448 of the amino acid sequence represented by UniProtKB:Q9JLN9-1. UniProtKB:Q9JLN9-1, Ser-2448, MOD:00046.


name: serine/threonine-protein kinase mTOR isoform 1 unphosphorylated 1 (mouse)

description: A serine/threonine-protein kinase mTOR isoform 1 (mouse) that lacks phosphorylation at at position equivalent to Ser-2448 of the amino acid sequence represented by UniProtKB:Q9JLN9-1. UniProtKB:Q9JLN9-1, Ser-2448, PR:000026291.


thermosensory behavior

description: Behavior that is dependent upon the sensation of temperature.


sperm motility

description: Any process involved in the controlled movement of a sperm cell.


wybutosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.


A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.


cardiac ventricle

description: Cardiac chamber through which blood leaves the heart.


name: regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

description: Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.


name: ventricular cardiac muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.


long-chain fatty acid import into cell

description: The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: long-chain fatty-acyl-CoA metabolic process

description: The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


dTMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).


tetrahydrofolate interconversion

description: The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.


dTDP

A thymidine phosphate having a diphosphate group at the 5'-position.


name: NDKA_HUMAN Nucleoside diphosphate kinase A (sprot)

description: A nucleoside diphosphate kinase A that is encoded in the genome of human.


purine nucleotide binding

description: Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate.


description: Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP.


description: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide.


name: B3GN9_HUMAN UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (sprot)

description: A UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 that is encoded in the genome of human.


name: B3GN6_HUMAN Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (sprot)

description: An acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase that is encoded in the genome of human.


name: B3GN8_HUMAN UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (sprot)

description: A UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 that is encoded in the genome of human.


name: B3GN5_HUMAN Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (sprot)

description: A UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 that is encoded in the genome of human.


name: regulation of protein export from nucleus

description: Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm.


mitotic spindle disassembly

description: The controlled breakdown of the spindle during a mitotic cell cycle.


protein localization to nucleolus

description: A process in which a protein is transported to, or maintained in, a location within a nucleolus.


Sid2-Mob1 complex

description: A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex.


voltage-gated sodium channel complex

description: A sodium channel in a cell membrane whose opening is governed by the membrane potential.


name: cardiac pacemaker cell of sinoatrial node

description: A nodal myocyte that is part of the sinoatrial node.


name: voltage-gated sodium channel activity involved in SA node cell action potential

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: regulation of ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.