name: KDM1B_HUMAN Lysine-specific histone demethylase 2 (sprot)

description: A lysine-specific histone demethylase 2 that is encoded in the genome of human.


name: NEIL3_HUMAN Endonuclease 8-like 3 (sprot)

description: An endonuclease 8-like 3 that is encoded in the genome of human.


MCM8_HUMAN DNA helicase MCM8 (sprot)

A DNA helicase MCM8 that is encoded in the genome of human.


name: IPMK_HUMAN Inositol polyphosphate multikinase (sprot)

description: An inositol polyphosphate multikinase that is encoded in the genome of human.


name: KMT2D_HUMAN Histone-lysine N-methyltransferase 2D (sprot)

description: A histone-lysine N-methyltransferase 2D that is encoded in the genome of human.


name: PHF8_HUMAN Histone lysine demethylase PHF8 (sprot)

description: A histone lysine demethylase PHF8 that is encoded in the genome of human.


name: DOT1L_HUMAN Histone-lysine N-methyltransferase, H3 lysine-79 specific (sprot)

description: A histone-lysine N-methyltransferase, H3 lysine-79 specific that is encoded in the genome of human.


name: SET1B_HUMAN Histone-lysine N-methyltransferase SETD1B (sprot)

description: A histone-lysine N-methyltransferase SETD1B that is encoded in the genome of human.


name: KAD6_HUMAN Adenylate kinase isoenzyme 6 (sprot)

description: An adenylate kinase isoenzyme 6 that is encoded in the genome of human.


name: BAP1_HUMAN Ubiquitin carboxyl-terminal hydrolase BAP1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase BAP1 that is encoded in the genome of human.


name: UBP47_HUMAN Ubiquitin carboxyl-terminal hydrolase 47 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 47 that is encoded in the genome of human.


name: UBP24_HUMAN Ubiquitin carboxyl-terminal hydrolase 24 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 24 that is encoded in the genome of human.


name: UBP28_HUMAN Ubiquitin carboxyl-terminal hydrolase 28 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 28 that is encoded in the genome of human.


name: UBP37_HUMAN Ubiquitin carboxyl-terminal hydrolase 37 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 37 that is encoded in the genome of human.


name: TRM1_HUMAN tRNA (guanine(26)-N(2))-dimethyltransferase (sprot)

description: An N(2),N(2)-dimethylguanosine tRNA methyltransferase that is encoded in the genome of human.


name: TM10A_HUMAN tRNA methyltransferase 10 homolog A (sprot)

description: A tRNA methyltransferase 10 homolog A that is encoded in the genome of human.


name: pseudouridylate synthase 1 homolog isoform h2 (human)

description: A pseudouridylate synthase 1 homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y606-2.


name: PUS7_HUMAN Pseudouridylate synthase 7 homolog (sprot)

description: A pseudouridylate synthase 7 that is encoded in the genome of human.


name: ADAT1_HUMAN tRNA-specific adenosine deaminase 1 (sprot)

description: A tRNA-specific adenosine deaminase 1 that is encoded in the genome of human.


name: FBRL_HUMAN rRNA 2'-O-methyltransferase fibrillarin (sprot)

description: An rRNA 2'-O-methyltransferase fibrillarin that is encoded in the genome of human.


name: NOP2_HUMAN Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (sprot)

description: A probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase that is encoded in the genome of human.


name: NAT10_HUMAN RNA cytidine acetyltransferase (sprot)

description: An RNA cytidine acetyltransferase that is encoded in the genome of human.


name: SMYD2_HUMAN N-lysine methyltransferase SMYD2 (sprot)

description: An N-lysine methyltransferase SMYD2 that is encoded in the genome of human.


name: SETD9_HUMAN SET domain-containing protein 9 (sprot)

description: A SET domain-containing protein 9 that is encoded in the genome of human.


name: PPME1_HUMAN Protein phosphatase methylesterase 1 (sprot)

description: A protein phosphatase methylesterase 1 that is encoded in the genome of human.


name: tyrosine-protein phosphatase non-receptor type 2 isoform h2 (human)

description: A tyrosine-protein phosphatase non-receptor type 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17706-2.


PIR_HUMAN Pirin (sprot)

A pirin that is encoded in the genome of human.


name: CSN5_HUMAN COP9 signalosome complex subunit 5 (sprot)

description: A COP9 signalosome complex subunit 5 that is encoded in the genome of human.


name: PPM1E_HUMAN Protein phosphatase 1E (sprot)

description: A protein phosphatase 1E that is encoded in the genome of human.


name: JHD2C_HUMAN Probable JmjC domain-containing histone demethylation protein 2C (sprot)

description: A probable JmjC domain-containing histone demethylation protein 2C that is encoded in the genome of human.


name: UTY_HUMAN Histone demethylase UTY (sprot)

description: A histone demethylase UTY that is encoded in the genome of human.


name: CC14B_HUMAN Dual specificity protein phosphatase CDC14B (sprot)

description: A dual specificity protein phosphatase CDC14B that is encoded in the genome of human.


name: KDM5A_HUMAN Lysine-specific demethylase 5A (sprot)

description: A lysine-specific demethylase 5A that is encoded in the genome of human.


name: KDM5C_HUMAN Lysine-specific demethylase 5C (sprot)

description: A lysine-specific demethylase 5C that is encoded in the genome of human.


name: DUS3_HUMAN Dual specificity protein phosphatase 3 (sprot)

description: A dual specificity protein phosphatase 3 that is encoded in the genome of human.


name: KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (sprot)

description: A histone-lysine N-methyltransferase KMT5B that is encoded in the genome of human.


name: PADI6_HUMAN Protein-arginine deiminase type-6 (sprot)

description: A protein-arginine deiminase type-6 that is encoded in the genome of human.


name: KDM7A_HUMAN Lysine-specific demethylase 7A (sprot)

description: A lysine-specific demethylase 7A that is encoded in the genome of human.


name: KDM3B_HUMAN Lysine-specific demethylase 3B (sprot)

description: A lysine-specific demethylase 3B that is encoded in the genome of human.


name: KMT5C_HUMAN Histone-lysine N-methyltransferase KMT5C (sprot)

description: A histone-lysine N-methyltransferase KMT5C that is encoded in the genome of human.


name: RIOX2_HUMAN Ribosomal oxygenase 2 (sprot)

description: A ribosomal oxygenase 2 that is encoded in the genome of human.


name: KDM2B_HUMAN Lysine-specific demethylase 2B (sprot)

description: A lysine-specific demethylase 2B that is encoded in the genome of human.


name: NSD1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-36 specific (sprot)

description: A histone-lysine N-methyltransferase, H3 lysine-36 specific that is encoded in the genome of human.


name: SETB2_HUMAN Histone-lysine N-methyltransferase SETDB2 (sprot)

description: A histone-lysine N-methyltransferase SETDB2 that is encoded in the genome of human.


name: UBP26_HUMAN Ubiquitin carboxyl-terminal hydrolase 26 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 26 that is encoded in the genome of human.


name: KDM5D_HUMAN Lysine-specific demethylase 5D (sprot)

description: A lysine-specific demethylase 5D that is encoded in the genome of human.


name: UBP42_HUMAN Ubiquitin carboxyl-terminal hydrolase 42 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 42 that is encoded in the genome of human.


name: ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (sprot)

description: A histone-lysine N-methyltransferase ASH1L that is encoded in the genome of human.


name: PADI1_HUMAN Protein-arginine deiminase type-1 (sprot)

description: A protein-arginine deiminase type-1 that is encoded in the genome of human.


name: PADI3_HUMAN Protein-arginine deiminase type-3 (sprot)

description: A protein-arginine deiminase type-3 that is encoded in the genome of human.


name: PADI4_HUMAN Protein-arginine deiminase type-4 (sprot)

description: A protein-arginine deiminase type-4 that is encoded in the genome of human.


name: PADI2_HUMAN Protein-arginine deiminase type-2 (sprot)

description: A protein-arginine deiminase type-2 that is encoded in the genome of human.


name: KDM2A_HUMAN Lysine-specific demethylase 2A (sprot)

description: A lysine-specific demethylase 2A that is encoded in the genome of human.


name: KDM3A_HUMAN Lysine-specific demethylase 3A (sprot)

description: A lysine-specific demethylase 3A that is encoded in the genome of human.


name: UBP16_HUMAN Ubiquitin carboxyl-terminal hydrolase 16 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 16 that is encoded in the genome of human.


name: UBP3_HUMAN Ubiquitin carboxyl-terminal hydrolase 3 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 3 that is encoded in the genome of human.


Pyrin domain binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.


intrahepatic bile duct development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).


name: regulation of granulocyte differentiation

description: Any process that modulates the frequency, rate or extent of granulocyte differentiation.


name: negative regulation of granulocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.


name: positive regulation of granulocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.


name: IL6RA_HUMAN Interleukin-6 receptor subunit alpha (sprot)

description: An interleukin-6 receptor subunit alpha that is encoded in the genome of human.


name: KLF5_HUMAN Krueppel-like factor 5 (sprot)

description: A krueppel-like factor 5 that is encoded in the genome of human.


name: CSF3R_HUMAN Granulocyte colony-stimulating factor receptor (sprot)

description: A granulocyte colony-stimulating factor receptor that is encoded in the genome of human.


name: SPI1_HUMAN Transcription factor PU.1 (sprot)

description: A transcription factor PU.1 that is encoded in the genome of human.


name: MYB_HUMAN Transcriptional activator Myb (sprot)

description: A myb proto-oncogene protein that is encoded in the genome of human.


name: transcription factor PML isoform 4 (human)

description: A transcription factor PML isoform 4 that is encoded in the genome of human.


name: TAL1_HUMAN T-cell acute lymphocytic leukemia protein 1 (sprot)

description: A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human.


name: GATA2_HUMAN Endothelial transcription factor GATA-2 (sprot)

description: An endothelial transcription factor GATA-2 that is encoded in the genome of human.


name: FLI1_HUMAN Friend leukemia integration 1 transcription factor (sprot)

description: A Friend leukemia integration 1 transcription factor that is encoded in the genome of human.


name: LEF1_HUMAN Lymphoid enhancer-binding factor 1 (sprot)

description: A lymphoid enhancer-binding factor 1 that is encoded in the genome of human.


name: CEBPE_HUMAN CCAAT/enhancer-binding protein epsilon (sprot)

description: A CCAAT/enhancer-binding protein epsilon that is encoded in the genome of human.


A0A1W6AWH1_MOUSE Nurim (trembl)

A nurim isoform 2 that is encoded in the genome of mouse.


nurim isoform 1 (mouse)

A nurim isoform 1 that is encoded in the genome of mouse.


name: TM168_HUMAN Transmembrane protein 168 (sprot)

description: A transmembrane protein 168 that is encoded in the genome of human.


name: dendritic transport of messenger ribonucleoprotein complex

description: The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.


adaptive thermogenesis

description: The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.


name: extrinsic component of matrix side of mitochondrial inner membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


oleate

A C18, long straight-chain monounsaturated fatty acid anion; and the conjugate base of oleic acid, arising from deprotonation of the carboxylic acid group.


N-oleoyl-L-phenylalaninate

An N-acyl-L-alpha-amino acid anion resulting from the deprotonation of the carboxy group of N-oleoyl-L-phenylalanine. The major species at pH 7.3.


striated muscle cell development

description: The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.


name: establishment of cell polarity involved in gastrulation cell migration

description: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.


protein tyrosine kinase binding

description: Binding to protein tyrosine kinase.


name: interleukin-1 receptor accessory protein isoform m2 (mouse)

description: An interleukin-1 receptor accessory protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61730-2.


name: negative regulation of protein tyrosine kinase activity

description: Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.


name: proto-oncogene tyrosine-protein kinase Src phosphorylated 2 (mouse)

description: A proto-oncogene tyrosine-protein kinase Src (mouse) that has been phosphorylated at the residue equivalent to Tyr-418 of the amino acid sequence represented by UniProtKB:P05480-2. UniProtKB:P05480, Tyr-418, MOD:00048.


name: proto-oncogene tyrosine-protein kinase Src unphosphorylated 2 (mouse)

description: A proto-oncogene tyrosine-protein kinase Src (mouse) that lacks phosphorylation at the position equivalent to Tyr-418 of the amino acid sequence represented by UniProtKB:P05480-2. UniProtKB:P05480, Tyr-418, PR:000026291.


name: detection of mechanical stimulus involved in sensory perception of pain

description: The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.


name: cellular response to transforming growth factor beta stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.


name: cellular response to platelet-derived growth factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.


name: negative regulation of protein autophosphorylation

description: Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.


name: negative regulation of T cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.


name: effector CD8-positive, alpha-beta T cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive.


name: effector CD4-positive, alpha-beta T cell

description: A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive.


basal ganglion

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified].


name: peripheral nervous system myelin maintenance

description: The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state.


cellular response to peptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.


name: regulation of neuron projection development

description: Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


name: cellular response to granulocyte macrophage colony-stimulating factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.


positive regulation of organ growth

description: Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.


name: cellular response to prostaglandin E stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.


maternal placenta development

description: Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


name: cellular response to decreased oxygen levels

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.


mammalian oogenesis stage

description: A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell.


name: cellular response to vascular endothelial growth factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.


name: glycogen cell differentiation involved in embryonic placenta development

description: The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer.


name: post-translational protein targeting to membrane, translocation

description: The process in which a protein translocates through the ER membrane posttranslationally.


protein deglycosylation

description: The removal of sugar residues from a glycosylated protein.


name: negative regulation of amyloid precursor protein biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.


SREBP signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.


negative regulation of neuron migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.


sexual reproduction

description: A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).


name: negative regulation of stem cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.


name: positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.


muscle tissue morphogenesis

description: The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.


complement component C3b binding

description: Binding to a C3b product of the complement cascade.


mitochondrial DNA metabolic process

description: The chemical reactions and pathways involving mitochondrial DNA.


name: cone retinal bipolar cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell.


mitochondrial gene expression

description: The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.


lipoprotein particle binding

description: Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.


name: vascular associated smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.


activation of membrane attack complex

description: The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.


immune complex clearance

description: A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.


name: organ or tissue specific immune response

description: An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.


immunoglobulin mediated immune response

description: An immune response mediated by immunoglobulins, whether cell-bound or in solution.


name: regulation of complement-dependent cytotoxicity

description: Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.


cochlea morphogenesis

description: The process in which the cochlea is generated and organized.


name: convergent extension involved in neural plate elongation

description: The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate.


protein localization to microtubule

description: A process in which a protein is transported to, or maintained at, a microtubule.


name: regulation of postsynapse to nucleus signaling pathway

description: Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway.


name: regulation of microtubule cytoskeleton organization

description: Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.


name: positive regulation of protein tyrosine kinase activity

description: Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.


name: positive regulation of hepatocyte proliferation

description: Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation.


name: axis elongation involved in somitogenesis

description: The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis.


name: paraxial mesodermal cell fate commitment

description: The process in which a cell becomes committed to become a paraxial mesoderm cell.


name: positive regulation of collateral sprouting in absence of injury

description: Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury.


name: positive regulation of cell-cell adhesion mediated by cadherin

description: Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.


name: positive regulation of Wnt protein secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell.


FZD6_MOUSE Frizzled-6 (sprot)

A frizzled-6 that is encoded in the genome of mouse.


response to oxygen levels

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


name: positive regulation of skeletal muscle tissue development

description: Any process that activates, maintains or increases the rate of skeletal muscle tissue development.


name: POU domain, class 5, transcription factor 1 isoform 1 (mouse)

description: A POU domain, class 5, transcription factor 1 isoform 1 that is encoded in the genome of mouse.


name: lysosomal cobalamin transport escort protein LMBD1 isoform 1 (mouse)

description: A lysosomal cobalamin transport escort protein LMBD1 isoform 1 that is encoded in the genome of mouse.


name: syncytium formation by plasma membrane fusion

description: The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


name: negative regulation of syncytium formation by plasma membrane fusion

description: Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


name: positive regulation of peptidyl-lysine acetylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.


name: regulation of triglyceride metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.


methyl-CpG binding

description: Binding to a methylated cytosine/guanine dinucleotide.


eukaryotic initiation factor 4E binding

description: Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.


negative regulation of mRNA processing

description: Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing.


establishment of RNA localization

description: The directed movement of RNA to a specific location.


name: translation regulator activity, nucleic acid binding

description: Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.


name: 4EBP2_HUMAN Eukaryotic translation initiation factor 4E-binding protein 2 (sprot)

description: A eukaryotic translation initiation factor 4E-binding protein 2 that is encoded in the genome of human.


name: CNOT7_HUMAN CCR4-NOT transcription complex subunit 7 (sprot)

description: A CCR4-NOT transcription complex subunit 7 that is encoded in the genome of human.


regulation of embryonic development

description: Any process that modulates the frequency, rate or extent of embryonic development.


name: positive regulation of embryonic development

description: Any process that activates or increases the frequency, rate or extent of embryonic development.


name: HXB1_HUMAN Homeobox protein Hox-B1 (sprot)

description: A homeobox protein Hox-B1 that is encoded in the genome of human.


name: CTCF_HUMAN Transcriptional repressor CTCF (sprot)

description: A transcriptional repressor CTCF that is encoded in the genome of human.


name: HXC4_HUMAN Homeobox protein Hox-C4 (sprot)

description: A homeobox protein Hox-C4 that is encoded in the genome of human.


name: HXB4_HUMAN Homeobox protein Hox-B4 (sprot)

description: A homeobox protein Hox-B4 that is encoded in the genome of human.


name: MAFB_HUMAN Transcription factor MafB (sprot)

description: A transcription factor MafB that is encoded in the genome of human.


name: HXD4_HUMAN Homeobox protein Hox-D4 (sprot)

description: A homeobox protein Hox-D4 that is encoded in the genome of human.


name: HXD3_HUMAN Homeobox protein Hox-D3 (sprot)

description: A homeobox protein Hox-D3 that is encoded in the genome of human.


name: PAX6_HUMAN Paired box protein Pax-6 (sprot)

description: A paired box protein Pax-6 that is encoded in the genome of human.


name: MEIS1_HUMAN Homeobox protein Meis1 (sprot)

description: A homeobox protein Meis1 that is encoded in the genome of human.


name: PCGF2_HUMAN Polycomb group RING finger protein 2 (sprot)

description: A Polycomb group RING finger protein 2 that is encoded in the genome of human.


name: EGR2_HUMAN E3 SUMO-protein ligase EGR2 (sprot)

description: An early growth response protein 2 that is encoded in the genome of human.


name: HXB2_HUMAN Homeobox protein Hox-B2 (sprot)

description: A homeobox protein Hox-B2 that is encoded in the genome of human.


name: HXA4_HUMAN Homeobox protein Hox-A4 (sprot)

description: A homeobox protein Hox-A4 that is encoded in the genome of human.


name: HXA2_HUMAN Homeobox protein Hox-A2 (sprot)

description: A homeobox protein Hox-A2 that is encoded in the genome of human.


name: HXA1_HUMAN Homeobox protein Hox-A1 (sprot)

description: A homeobox protein Hox-A1 that is encoded in the genome of human.


name: HXB3_HUMAN Homeobox protein Hox-B3 (sprot)

description: A homeobox protein Hox-B3 that is encoded in the genome of human.


name: HXD1_HUMAN Homeobox protein Hox-D1 (sprot)

description: A homeobox protein Hox-D1 that is encoded in the genome of human.


name: HXA3_HUMAN Homeobox protein Hox-A3 (sprot)

description: A homeobox protein Hox-A3 that is encoded in the genome of human.


name: negative regulation of oocyte maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.


name: regulation of retinal ganglion cell axon guidance

description: Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


genitourinary system

description: Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.


kidney cell

description: A cell that is part of a kidney.


collagen type I trimer

description: A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.


platelet-derived growth factor binding

description: Binding to platelet-derived growth factor.


skeletal system morphogenesis

description: The process in which the anatomical structures of the skeleton are generated and organized.


name: negative regulation of cell-substrate adhesion

description: Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


sodium ion transmembrane transport

description: A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


name: detection of temperature stimulus involved in sensory perception of pain

description: The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.


name: detection of mechanical stimulus involved in sensory perception

description: The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception.


P-type ion transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.


myelinating glial cell

description: A glial cell that myelinates axonal processes.


name: SF3B1_HUMAN Splicing factor 3B subunit 1 (sprot)

description: A splicing factor 3B subunit 1 that is encoded in the genome of human.


name: retina vasculature development in camera-type eye

description: The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.


name: regulation of semaphorin-plexin signaling pathway

description: Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway.


name: insulin-like growth factor receptor binding

description: Binding to an insulin-like growth factor receptor.


juxtaglomerular apparatus development

description: The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function.


name: common myeloid progenitor cell proliferation

description: The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.


name: regulation of striated muscle cell differentiation

description: Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.


myoblast fusion

description: A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


male organism

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Gonochoristic organism that can produce male gametes.


name: negative regulation of cytokine production involved in inflammatory response

description: Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.


interleukin-6 receptor binding

description: Binding to an interleukin-6 receptor.


myeloid cell homeostasis

description: The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


name: branching involved in salivary gland morphogenesis

description: The process in which the branching structure of the salivary gland is generated and organized.


name: cellular response to hepatocyte growth factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.


cellular response to interleukin-1

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.


name: negative regulation of hormone secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.


name: positive regulation of T-helper 2 cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.


T-helper 2 cell differentiation

description: The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4.


neutrophil apoptotic process

description: Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.


mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.


name: positive regulation of lipoprotein lipase activity

description: Any process that activates or increases the activity of the enzyme lipoprotein lipase.


astrocyte activation

description: A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


response to carbohydrate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.


steroid hormone aporeceptor complex

description: A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand.


tumor necrosis factor receptor binding

description: Binding to a tumor necrosis factor receptor.


humoral immune response

description: An immune response mediated through a body fluid.


name: positive regulation of calcineurin-NFAT signaling cascade

description: Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.


defense response

description: Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.


name: positive regulation of chronic inflammatory response to antigenic stimulus

description: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


name: positive regulation of humoral immune response mediated by circulating immunoglobulin

description: Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.


name: regulation of branching involved in salivary gland morphogenesis

description: Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium.


name: positive regulation of translational initiation by iron

description: Any process involving iron that activates or increases the rate of translational initiation.


cellular extravasation

description: The migration of a leukocyte from the blood vessels into the surrounding tissue.


name: production of molecular mediator involved in inflammatory response

description: The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.


name: negative regulation of triglyceride metabolic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.


lipoprotein biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


cholesterol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


maintenance of location in cell

description: Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.


name: high-density lipoprotein particle binding

description: Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.


phagocytosis, recognition

description: The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell.


name: positive regulation of macrophage cytokine production

description: Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: positive regulation of phagocytosis, engulfment

description: Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


mesenchymal cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.


neural plate morphogenesis

description: The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.


name: negative regulation of cartilage development

description: Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


protein import

description: The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.


maintenance of protein location

description: Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.


name: negative regulation of cytokine production

description: Any process that stops, prevents, or reduces the rate of production of a cytokine.


rhombomere 5 formation

description: The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


rhombomere 3 development

description: The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


rhombomere 3 formation

description: The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


facial nerve structural organization

description: The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.


embryo implantation

description: Attachment of the blastocyst to the uterine lining.


decidualization

description: The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.


prostaglandin secretion

description: The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue.


name: vascular associated smooth muscle contraction

description: A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion.


luteinization

description: The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.


Leydig cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.


estrogen metabolic process

description: The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.


adaptive immune response

description: An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).


cellular response to cholesterol

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.


name: SREBP-SCAP complex retention in endoplasmic reticulum

description: Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER.


name: cholesterol biosynthetic process via desmosterol

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol.


name: cholesterol biosynthetic process via lathosterol

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol.


intestinal lipid absorption

description: A process in which lipids are taken up from the contents of the intestine.


A member of the class of thienotriazolodiazepines that is the tert-butyl ester of [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid. An inhibitor of bromodomain-containing protein 4 that exhibits anti-cancer and cardioprotective properties.


aspirin

A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.


fenofibrate

A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.


FINGOLIMOD HYDROCHLORIDE

The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).


TRIACSIN C

A nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters.


DISOGENIN

A  sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.


probucol

A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.


mitotic cell cycle process

description: A process that is part of the mitotic cell cycle.


myoblast proliferation

description: The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


regulation of myoblast proliferation

description: Any process that modulates the frequency, rate or extent of myoblast proliferation.


positive regulation of glucose import

description: Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.


name: positive regulation of fatty acid metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


name: regulation of cellular metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


dendritic cell proliferation

description: The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


name: leukocyte chemotaxis involved in inflammatory response

description: The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.


protein-DNA complex

description: A macromolecular complex containing both protein and DNA molecules.


sex chromatin

description: Chromatin that is part of a sex chromosome.


name: cardiac muscle cell myoblast differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.


cardiac cell fate determination

description: The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.


positive regulation of DNA binding

description: Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).


name: positive regulation of cardiac muscle cell proliferation

description: Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.


tube morphogenesis

description: The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.


name: cellular response to gonadotropin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.


Sertoli cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.


lung lobe formation

description: The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung.


stem cell division

description: The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.


name: negative regulation of cell fate commitment

description: Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


cardioblast migration

description: The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


regulation of heart rate

description: Any process that modulates the frequency or rate of heart contraction.


actin filament-based movement

description: Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.


regulation of heart growth

description: Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.


regulation of ATP-dependent activity

description: Any process that modulates the rate of an ATP-dependent activity.


visceral muscle development

description: The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.


cardiac muscle cell action potential

description: An action potential that occurs in a cardiac muscle cell.


renal filtration

description: A renal system process in which fluid circulating through the body is filtered through a barrier system.


osteoblast fate commitment

description: The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.


name: positive regulation of chondrocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.


name: multicellular organismal response to stress

description: Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


name: regulation of skeletal muscle fiber development

description: Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


response to cocaine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.


erythroid progenitor cell, mammalian

description: A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).


p53 binding

description: Binding to one of the p53 family of proteins.


name: regulation of primitive erythrocyte differentiation

description: Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.


name: positive regulation of osteoblast proliferation

description: Any process that activates or increases the rate or extent of osteoblast proliferation.


cardiac cell fate commitment

description: The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system.


phagocytic vesicle

description: A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.


structural constituent of eye lens

description: The action of a molecule that contributes to the structural integrity of the lens of an eye.


name: negative regulation of neuron projection development

description: Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


intermediate filament-based process

description: Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.


regulation of granuloma formation

description: Any process that modulates the frequency, rate, or extent of granuloma formation.


granulocyte chemotaxis

description: The movement of a granulocyte in response to an external stimulus.


cellular response to vitamin D

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.


name: granulocyte colony-stimulating factor binding

description: Binding to granulocyte colony-stimulating factor, G-CSF.


cellular response to phenylalanine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus.


name: regulation of SMAD protein signal transduction

description: Any process that modulates the rate, frequency or extent of SMAD protein signal transduction.


name: positive regulation of exit from mitosis

description: Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).


PRC1 complex

description: A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.


heterochromatin

description: A compact and highly condensed form of chromatin that is refractory to transcription.


euchromatin

description: A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.


name: ubiquitin-protein transferase activator activity

description: Binds to and increases the activity of a ubiquitin-protein transferase.


name: VEMP_SARS2 Envelope small membrane protein (sprot)

description: A protein that is a translation product of the E gene in SARS-CoV-2.


name: transient receptor potential cation channel subfamily V member 1 isoform 1 (mouse)

description: A transient receptor potential cation channel TRPV1 isoform 1 that is encoded in the genome of mouse.


regulation of endocytosis

description: Any process that modulates the frequency, rate or extent of endocytosis.


phosphatidylinositol dephosphorylation

description: The process of removing one or more phosphate groups from a phosphatidylinositol.


ARRS_HUMAN S-arrestin (sprot)

An S-arrestin that is encoded in the genome of human.


rhodopsin kinase activity

description: Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin.


name: NAADP-sensitive calcium-release channel activity

description: Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts.


hexose metabolic process

description: The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.


axonal transport of mitochondrion

description: The directed movement of mitochondria along microtubules in nerve cell axons.


name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


name: SOX2_HUMAN Transcription factor SOX-2 (sprot)

description: A transcription factor SOX-2 that is encoded in the genome of human.


name: MOBP_HUMAN Myelin-associated oligodendrocyte basic protein (sprot)

description: A myelin-associated oligodendrocyte basic protein that is encoded in the genome of human.


PRVA_HUMAN Parvalbumin alpha (sprot)

A parvalbumin alpha that is encoded in the genome of human.


extraocular skeletal muscle development

description: The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.


nucleate erythrocyte development

description: The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


U2-type spliceosomal complex

description: Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.


name: SRSF2_HUMAN Serine/arginine-rich splicing factor 2 (sprot)

description: A splicing factor, arginine/serine-rich 2 that is encoded in the genome of human.


name: SRSF1_HUMAN Serine/arginine-rich splicing factor 1 (sprot)

description: A splicing factor, arginine/serine-rich 1 that is encoded in the genome of human.


name: SRSF6_HUMAN Serine/arginine-rich splicing factor 6 (sprot)

description: A serine/arginine-rich splicing factor 6 that is encoded in the genome of human.


name: U2AFM_HUMAN U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (sprot)

description: A U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 that is encoded in the genome of human.


name: SUGP1_HUMAN SURP and G-patch domain-containing protein 1 (sprot)

description: A splicing factor 4 that is encoded in the genome of human.


name: MTREX_HUMAN Exosome RNA helicase MTR4 (sprot)

description: An exosome RNA helicase MTR4 that is encoded in the genome of human.


name: F8WJG3_MOUSE Transformer 2 beta (trembl)

description: A transformer-2 protein homolog beta isoform 3 that is encoded in the genome of mouse.


skeletal muscle thin filament assembly

description: The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.


name: striated muscle myosin thick filament assembly

description: The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.


name: positive regulation of myoblast proliferation

description: Any process that activates or increases the frequency, rate or extent of myoblast proliferation.


intracellular cholesterol transport

description: The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.


Cajal body

description: A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.


sno(s)RNA metabolic process

description: The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA.


name: macrophage activation involved in immune response

description: A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


name: negative regulation of neutrophil differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation.


name: positive regulation of skeletal muscle tissue regeneration

description: Any process that activates or increase the rate of skeletal muscle regeneration.


embryonic placenta morphogenesis

description: The process in which the embryonic placenta is generated and organized.


intracellular oxygen homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell.


chorio-allantoic fusion

description: The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois.


homeostatic process

description: Any biological process involved in the maintenance of an internal steady state.


anatomical structure regression

description: The developmental process in which an anatomical structure is destroyed as a part of its normal progression.


trachea cartilage morphogenesis

description: The process in which the anatomical structures of cartilage in the trachea are generated and organized.


metanephric collecting duct development

description: The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder.


name: establishment or maintenance of polarity of embryonic epithelium

description: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo.


name: developmental growth involved in morphogenesis

description: The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.


name: outer medullary collecting duct development

description: The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla.


metanephric loop of Henle development

description: The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros.


name: inner medullary collecting duct development

description: The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla.


lobar bronchus development

description: The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi.


metanephric epithelium development

description: The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


FZD1_MOUSE Frizzled-1 (sprot)

A frizzled-1 that is encoded in the genome of mouse.


FZD10_MOUSE Frizzled-10 (sprot)

A frizzled-10 that is encoded in the genome of mouse.


RISC complex

description: A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.


female pregnancy

description: The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.


name: cellular response to dexamethasone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.


cellular response to interleukin-6

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.


name: cardiac vascular smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers.


name: aorta smooth muscle tissue morphogenesis

description: The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.


name: negative regulation of extrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.


renal protein absorption

description: A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).


name: positive regulation of adipose tissue development

description: Any process that activates or increases the frequency, rate or extent of adipose tissue development.


name: inhibition of cysteine-type endopeptidase activity

description: Any process that prevents the activation of an inactive cysteine-type endopeptidase.


name: cysteine-type endopeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase.


name: negative regulation of phagocytosis, engulfment

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


name: quaternary ammonium group transmembrane transporter activity

description: Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.


quaternary ammonium group transport

description: The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.


histamine transport

description: The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


histamine uptake

description: The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.


regulation of appetite

description: Any process which modulates appetite, the desire or physical craving for food.


organic cation transport

description: The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.


name: regulatory ncRNA-mediated heterochromatin formation

description: A heterochromatin formation-based gene silencing process mediated by a regulatory non-coding RNA molecule that occur before the beginning of trancription.


cimetidine

A member of the class of  guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a  H2-receptor antagonist that inhibits the production of acid in stomach.


ethidium

The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.


proton

Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.


digoxin

A  cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.


spironolactone

A  steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.


sulfadimethoxine

A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.


dexamfetamine

A 1-phenylpropan-2-amine that has S configuration.


amphetamine

A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.


topiramate

A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.


phenformin

A member of the class of biguanides that is  biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of  lactic acidosis.


prazosin

A member of the class of  piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.


phentolamine

A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.


amiloride

A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.


amantadine

A member of the class of  adamantanes that is used as an antiviral and  antiparkinson drug.


ticlopidine

A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.


flecainide

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).


sulpiride

A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.


diosmetin

A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities.


scopolamine

A tropane alkaloid that is the (S)-tropic acid ester of 6beta,7beta-epoxy-1alphaH,5alphaH-tropan-3alpha-ol.


vanoxerine

An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.


pyrimethamine

An aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis.


atropine

A  racemate composed of equimolar concentrations of (S)- and (R)-atropine . It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae.


diphenhydramine

An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.


trichlormethiazide

A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.


monensin

A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.


NSC 23766 trihydrochloride

A hydrochloride resulting from the formal reaction of NSC 23766 with 3 mol eq. of hydrogen chloride. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).


chloramphenicol

An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions.


cinchonine

Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.


TETRAPROPYLAMMONIUM

A quarternary ammonium cation with four propyl substituents around the central nitrogen.


CINCHONIDINE

8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.


papaverine

A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.


zonisamide

A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.


clobenpropit

An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.


TETRAMETHYLAMMONIUM ION

The simplest quaternary ammonium cation, comprising a central nitrogen linked to four methyl groups.


nadolol

Nadolol is a diastereoisomeric mixture consisting of equimolar amounts of the four possible 2,3-cis-isomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol.


midodrine

An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.


guanidine

An aminocarboxamidine, the parent compound of the guanidines.


sulfamerazine

A sulfonamide consisting of pyrimidine with a methyl substituent at the 4-position and a 4-aminobenzenesulfonamido group at the 2-position.


monocarboxylic acid transport

description: The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: L-hydroxyproline transmembrane transporter activity

description: Enables the transfer of L-hydroxyproline from one side of a membrane to the other.


name: UCP1_HUMAN Mitochondrial brown fat uncoupling protein 1 (sprot)

description: A mitochondrial brown fat uncoupling protein 1 that is encoded in the genome of human.


name: group XIIA secretory phospholipase A2 isoform m2 (mouse)

description: A group XIIA secretory phospholipase A2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EPR2-2.


name: negative regulation of activin receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway.


name: specification of animal organ axis polarity

description: The process in which the polarity of an animal organ axis is specified.


semicircular canal development

description: The progression of the semicircular canal from its initial formation to the mature structure.


equilibrioception

description: The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.


name: granulocyte colony-stimulating factor receptor binding

description: Binding to a granulocyte colony-stimulating factor receptor.


name: CSF3_MOUSE Granulocyte colony-stimulating factor (sprot)

description: A granulocyte colony-stimulating factor that is encoded in the genome of mouse.


spinal cord motor neuron migration

description: The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.


vestibulocochlear nerve development

description: The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.


auditory behavior

description: The behavior of an organism in response to a sound.


positive regulation of synapse assembly

description: Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.


vestibular reflex

description: A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.


linear vestibuloocular reflex

description: A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.


mesenchyme development

description: The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.


primary palate development

description: The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure.


suckling behavior

description: Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.


coronary artery morphogenesis

description: The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle.


name: cell proliferation involved in outflow tract morphogenesis

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.


visceral serous pericardium development

description: The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.


name: SPT6H_HUMAN Transcription elongation factor SPT6 (sprot)

description: A transcription elongation factor SPT6 that is encoded in the genome of human.


IWS1_HUMAN Protein IWS1 homolog (sprot)

A protein IWS1 that is encoded in the genome of human.


ribonucleoprotein complex localization

description: Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell.


name: regulation of timing of cell differentiation

description: The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.


name: commitment of neuronal cell to specific neuron type in forebrain

description: The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.


name: forebrain dorsal/ventral pattern formation

description: The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.


lacrimal gland development

description: The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.


regulation of asymmetric cell division

description: Any process that modulates the frequency, rate or extent of asymmetric cell division.


pallium development

description: The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.


oligodendrocyte cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


forebrain-midbrain boundary formation

description: The process whose specific outcome is the creation of the forebrain-midbrain boundary.


tube formation

description: Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.


synaptic target recognition

description: The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.


mesenchymal-epithelial cell signaling

description: Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.


histone H3K9 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9).


name: histone H3K14 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).


spliceosomal complex

description: Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.


mediator complex

description: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.