GATOR2 complex

description: A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.


name: MIOS_HUMAN GATOR2 complex protein MIOS (sprot)

description: A GATOR2 complex protein MIOS that is encoded in the genome of human.


myoblast development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


C-terminal protein demethylation

description: The removal of a methyl group from the C-terminal amino acid of a protein.


name: eukaryotic translation initiation factor 2B complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.


name: guanyl-nucleotide exchange factor complex

description: A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.


name: positive regulation of cellular response to amino acid starvation

description: Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.


name: positive regulation of double-strand break repair via nonhomologous end joining

description: Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.


name: negative regulation of DNA damage checkpoint

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint.


detoxification of iron ion

description: Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion.


intracellular manganese ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell.


iron(III) oxide-hydroxide(1-)

The inorganic anion obtained by deprotonation of iron(III) oxide-hydroxide; major species at pH 7.3.


iron-sulfur cluster

An iron-sulfur cluster is a unit comprising two or more iron atoms and bridging sulfur ligands.


name: FBXL5_HUMAN F-box/LRR-repeat protein 5 (sprot)

description: An F-box/LRR-repeat protein 5 that is encoded in the genome of human.


name: ACOHC_HUMAN Cytoplasmic aconitate hydratase (sprot)

description: A cytoplasmic aconitate hydratase that is encoded in the genome of human.


name: regulation of unidimensional cell growth

description: Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis.


actinin binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to actinin, any member of a family of proteins that crosslink F-actin.


name: termination of RNA polymerase II transcription, poly(A)-coupled

description: An RNA polymerase II transcription termination process in which cleavage and polyadenylylation of the mRNA 3' end are coupled to transcription termination.


name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


name: termination of RNA polymerase II transcription, exosome-dependent

description: The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end.


name: positive regulation of mitochondrial fusion

description: Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.


dihydrofolate metabolic process

description: The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.


name: tryptophan catabolic process to indole-3-acetate

description: The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate.


indole metabolic process

description: The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).


quinolinate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


L-tryptophan transmembrane transport

description: The directed movement of L-tryptophan across a membrane.


L-tryptophan decarboxylase activity

description: Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine.


tryptophanase activity

description: Catalysis of the reaction: L-tryptophan + H2O = indole + NH4 + pyruvate.


OXLA_HUMAN L-amino-acid oxidase (sprot)

An L-amino-acid oxidase that is encoded in the genome of human.


L-tryptophan aminotransferase activity

description: Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid.


name: regulation of silent mating-type cassette heterochromatin formation

description: Any process that modulates the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.


snRNA transcription

description: The synthesis of small nuclear RNA (snRNA) from a DNA template.


name: negative regulation of glucocorticoid receptor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.


multivesicular body-lysosome fusion

description: The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle.


name: negative regulation of sodium:proton antiporter activity

description: Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


name: SL9B2_HUMAN Sodium/hydrogen exchanger 9B2 (sprot)

description: A sodium/hydrogen exchanger 9B2 that is encoded in the genome of human.


name: SL9C1_HUMAN Solute carrier family 9 member C1 (sprot)

description: A sodium/hydrogen exchanger 10 that is encoded in the genome of human.


name: SL9A9_HUMAN Sodium/hydrogen exchanger 9 (sprot)

description: A sodium/hydrogen exchanger 9 that is encoded in the genome of human.


name: SL9A6_HUMAN Sodium/hydrogen exchanger 6 (sprot)

description: A sodium/hydrogen exchanger 6 that is encoded in the genome of human.


name: SL9A7_HUMAN Sodium/hydrogen exchanger 7 (sprot)

description: A sodium/hydrogen exchanger 7 that is encoded in the genome of human.


name: SL9A8_HUMAN Sodium/hydrogen exchanger 8 (sprot)

description: A sodium/hydrogen exchanger 8 that is encoded in the genome of human.


name: potassium:proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).


name: intracellular monoatomic cation homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.


response to angiotensin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.


name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade.


fibroblast growth factor binding

description: Binding to a fibroblast growth factor.


name: negative regulation of fibroblast growth factor production

description: Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: regulation of phosphorus metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.


name: positive regulation of parathyroid hormone secretion

description: Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion.


name: regulation of extrinsic apoptotic signaling pathway in absence of ligand

description: Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.


name: positive regulation of mitotic cell cycle DNA replication

description: Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication.


cysteaminium

An ammonium ion that is the conjugate acid of cysteamine; major species at pH 7.3.


phosphodiesterase I activity

description: Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.


name: negative regulation of alpha-beta T cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.


inflammatory cell apoptotic process

description: Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.


lymphocyte apoptotic process

description: Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


regulation of glomerular filtration

description: Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.


name: negative regulation of long-term synaptic depression

description: Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression.


oxygen metabolic process

description: The chemical reactions and pathways involving diatomic oxygen (O2).


name: angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure

description: The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.


peptidyl-lysine modification

description: The modification of peptidyl-lysine.


nerve growth factor binding

description: Binding to nerve growth factor (NGF).


death receptor activity

description: Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.


detection of temperature stimulus

description: The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal.


name: insulin-responsive glucose:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.


amylopectin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages.


description: Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.


embryonic nail plate morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits.


ceramide transport

description: The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.


name: positive regulation of epithelial cell proliferation involved in wound healing

description: Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.


name: chronic inflammatory response to antigenic stimulus

description: A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.


alveolar secondary septum development

description: The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule.


name: negative regulation of astrocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation.


name: negative regulation of mitotic nuclear division

description: Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.


substantia nigra development

description: The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).


name: regulation of collagen metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


amino acid metabolic process

description: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.


pheromone binding

description: Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.


name: relaxation of vascular associated smooth muscle

description: A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.


cardiac muscle tissue growth

description: The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.


name: sodium ion export across plasma membrane

description: The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.


name: receptor guanylyl cyclase signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: negative regulation of mitotic metaphase/anaphase transition

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


name: LTP_HHV11 Large tegument protein deneddylase (sprot)


name: positive regulation of protein K48-linked ubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination.


name: krueppel-like factor 4 ubiquitinated form (mouse)

description: A krueppel-like factor 4 (mouse) that includes at least one ubiquitinated lysine. UniProtKB:Q60793, MOD:01148.


name: natriuretic peptides A isoform 1 (mouse)

description: An atrial natriuretic factor isoform 1 that is encoded in the genome of mouse.


name: regulation of melanocyte differentiation

description: Any process that modulates the frequency, rate or extent of melanocyte differentiation.


cellular response to pH

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


ciliary body morphogenesis

description: The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.


facial nerve morphogenesis

description: The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.


name: regulation of synaptic assembly at neuromuscular junction

description: Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.


name: positive regulation of branching involved in ureteric bud morphogenesis

description: Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.


name: positive regulation of mesenchymal cell proliferation involved in ureter development

description: Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development.


cardiac ventricle formation

description: The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.


endothelin A receptor binding

description: Binding to an endothelin A receptor.


regulation of pH

description: Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.


name: protein kinase C-activating G protein-coupled receptor signaling pathway

description: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).


rhythmic excitation

description: Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.


name: positive regulation of renal sodium excretion

description: Any process that increases the amount of sodium excreted in urine over a unit of time.


positive regulation of urine volume

description: Any process that increases the amount of urine excreted from the body over a unit of time.


name: negative regulation of vascular associated smooth muscle cell migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.


name: negative regulation of vascular associated smooth muscle cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.


name: detection of chemical stimulus involved in sensory perception of pain

description: The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal.


thermoception

description: The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature).


olfactory pit development

description: The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx.


name: olfactory bulb interneuron differentiation

description: The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.


interneuron axon guidance

description: The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions.


name: positive regulation of cardiac muscle hypertrophy

description: Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.


name: positive regulation of heart rate by epinephrine-norepinephrine

description: The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.


name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

description: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.


name: positive regulation of the force of heart contraction by epinephrine-norepinephrine

description: Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.


name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin

description: The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.


posterior midgut development

description: The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure.


semaphorin receptor activity

description: Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


regulation of negative chemotaxis

description: Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical.


trigeminal nerve morphogenesis

description: The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.


chemorepulsion of branchiomotor axon

description: The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


name: postganglionic parasympathetic fiber development

description: The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.


slit diaphragm

description: A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.


name: negative regulation of stress fiber assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.


talin binding

description: Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types.


negative regulation of ruffle assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.


peptidyl-proline dioxygenase activity

description: Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.


vinculin binding

description: Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.


metanephric podocyte development

description: The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.


name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure

description: A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure.


storage vacuole

description: A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.


regulation of mitotic nuclear division

description: Any process that modulates the frequency, rate or extent of mitosis.


name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

description: Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure.


name: apoptotic process involved in outflow tract morphogenesis

description: Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.


brain renin-angiotensin system

description: The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.


name: regulation of smooth muscle cell apoptotic process

description: Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.


name: regulation of renal output by angiotensin

description: The process in which angiotensin directly modulates the rate of urine output by the kidney.


name: positive regulation of mesenchymal cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.


ubiquitin recycling

description: Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates.


tRNA wobble base cytosine methylation

description: The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.


endodermal cell fate determination

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.


rhombomere 2 development

description: The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


rhombomere 3 morphogenesis

description: The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.


calcitonin receptor binding

description: Binding to a calcitonin receptor.


muscle myosin complex

description: A filament of myosin found in a muscle cell of any type.


regulation of RNA splicing

description: Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.


otolith tethering

description: The attachment of a developing otolith to the kinocilia of tether cells in the inner ear.


protein decrotonylase activity

description: Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein].


peptide crotonyltransferase activity

description: Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide.


name: MARE1_HUMAN Microtubule-associated protein RP/EB family member 1 (sprot)

description: A microtubule-associated protein RP/EB family member 1 that is encoded in the genome of human.


mitotic metaphase

description: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.


mannosylphosphate transferase activity

description: Catalysis of the transfer of a mannosylphosphate group from one compound to another.


name: COPII-coated ER to Golgi transport vesicle

description: A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).


A 2-amino-1-hydroxyoctadecan-3-one that has S-configuration.


ceramide phosphoethanolamine

Any of a class of phosphosphingolipids in which the amino group of a sphingoid base is in amide linkage with one of several fatty acids, while the terminal hydroxy group of the sphingoid base is esterified to phosphorylethanolamine.


Any ceramide in which the acyl group carries a hydroxy substituent at position 2.


dihydrosphingosine 1-phosphate

A sphingoid 1-phosphate that is the monophosphorylated derivative of  sphinganine.


name: ACER2_HUMAN Alkaline ceramidase 2 (sprot)

description: An alkaline ceramidase 2 that is encoded in the genome of human.


name: SMS1_HUMAN Phosphatidylcholine:ceramide cholinephosphotransferase 1 (sprot)

description: A phosphatidylcholine:ceramide cholinephosphotransferase 1 that is encoded in the genome of human.


name: piezo-type mechanosensitive ion channel component 2 isoform m4 (mouse)

description: A piezo-type mechanosensitive ion channel component 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CD54-1 except that it is missing amino acids 1539-1561. UniProtKB:Q8CD54-1, 1-1538, 1562-2822.


name: piezo-type mechanosensitive ion channel component 2 isoform m1 (mouse)

description: A piezo-type mechanosensitive ion channel component 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CD54-1.


cellular response to acetylcholine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.


name: positive regulation of lipopolysaccharide-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


monocyte activation

description: The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


ascospore-type prospore assembly

description: During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane.


name: membrane addition at site of cytokinesis

description: Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.


category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone.


regulation of cation channel activity

description: Any process that modulates the frequency, rate or extent of cation channel activity.


response to potassium ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.


vascular process in circulatory system

description: A circulatory process that occurs at the level of the vasculature.


cellular response to chemical stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress.


cellular response to ATP

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.


response to hydrogen sulfide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus.


HYDROGEN SULFIDE

A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.


dimethylamine

A secondary aliphatic amine where both N-substituents are methyl.


aflatoxin Q1

A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at the pro-3S position is replaced by a hydroxy group.


aflatoxin M1

A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at position 9a is replaced by a hydroxy group.


sodium arsenate

An inorganic sodium salt composed from sodium cations and arsenate anions in a 3:1 ratio.


ARSENIC TRIOXIDE

An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.


(-)-adrenaline

The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.


mitoxantrone

A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.


lactic acid

A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.


tauroursodeoxycholic acid

A bile acid taurine conjugate derived from ursoodeoxycholic acid.


acid

An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).


ROSUVASTATIN CALCIUM

An organic calcium salt that is the hemicalcium salt of rosuvastatin.


A hydrate that is the trihydrate form of dipotassium bis[mu-tartrato(4-)]diantimonate(2-).


chenodeoxycholic acid

A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.


furosemide

A  chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.


prednisone

A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.


methylprednisolone

The 6alpha-stereoisomer of  6-methylprednisolone.


cholic acid

A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.


oxytocin

A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.


aminohippuric acid

An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.


succinic acid

An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.


pyruvic acid

A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.


TAURODEOXYCHOLIC ACID

A bile acid taurine conjugate of deoxycholic acid.


beta-endorphin

A polypeptide consisting of 31 amino acid residues in the sequence Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu.  It is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system and results from processing of the precursor protein proopiomelanocortin (POMC).


muricholic acids

A group of trihydroxy-5beta-cholanic acids that are the 6,7-diastereoisomers of 3alpha,6,7-trihydroxy-5beta-cholan-24-oic acid.


calcein am

An organic heteropentacyclic compound that is  calcein in which all four carboxy group hydrogens have been substituted by (acetyloxy)methoxy groups and the hyrodgens of the two hydroxy groups have been substituted by acetyl groups. It is a a non-fluorescent probe cleaved to a fluorescent probe by non-specific intracellular esterases.


A cholestanoid that is (5alpha)-cholestane substituted by a beta-hydroxy group at position 3.


OXYPURINOL

A  pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.


α-ketoisocaproate

A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.


DPDPE

A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.


lopinavir

A dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.


ACETAMINOPHEN GLUCURONIDE

A beta-D-glucosiduronic acid that is the O-glucuronide of paracetamol (acetaminophen).


ACTH

A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.


(+)-ABSCISIC ACID

The naturally occurring (1'S)-(+) enantiomer of abscisic acid. It is an important sesquiterpenoid plant hormone which acts as a regulator of plant responses to environmental stresses such as drought and cold.


anion

A monoatomic or polyatomic species having one or more elementary charges of the electron.


bendroflumethiazide

A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.


A glutathione conjugate in which the thiol hydrogen of glutathione has been replaced by a 2,4-dinitrophenyl group.


name: very low density lipoprotein triglyceride


cephalosporin

A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring.  Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy.


name: signal recognition particle, endoplasmic reticulum targeting

description: A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.


cortical granule

description: A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy.


name: central plaque of mitotic spindle pole body

description: One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body.


mitotic spindle pole body duplication

description: Any spindle pole body duplication that is involved in the mitotic cell cycle.


collagen type III trimer

description: A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils.


name: SMAD7_MOUSE Mothers against decapentaplegic homolog 7 (sprot)

description: A smad7 that is encoded in the genome of mouse.


name: negative regulation of transforming growth factor beta1 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1.


name: negative regulation of fibroblast proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.


keratocyte

description: A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.


cartilage homeostasis

description: A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function.


name: double-strand break repair via single-strand annealing

description: Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.


name: negative regulation of cytoplasmic mRNA processing body assembly

description: Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


name: TNNI3_HUMAN Troponin I, cardiac muscle (sprot)

description: A troponin I, cardiac muscle that is encoded in the genome of human.


TRC complex

description: A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane.


somatic muscle development

description: The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.


alpha-amino acid metabolic process

description: The chemical reactions and pathways involving an alpha-amino acid.


name: xenobiotic transmembrane transporter activity

description: Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


name: xenobiotic detoxification by transmembrane export across the plasma membrane

description: A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.


NatB complex

description: A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.


description: The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine.


name: histone H1.4, initiator methionine removed monomethylated 1 (mouse)

description: A histone H1.4, initiator methionine removed monomethylated 1 in mouse. UniProtKB:P43274, 2-219, Lys-26, MOD:00085.


Rpd3S complex

description: A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).


regulation of RNA stability

description: Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs.


FMN binding

description: Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.


flavin adenine dinucleotide binding

description: Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.


cob(II)alamin

A cobalamin in which the central cobalt atom has an oxidation state of +2.


succinyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of succinyl-CoA.


purine nucleotide uniporter activity

description: Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


name: ABCA5_HUMAN Cholesterol transporter ABCA5 (sprot)

description: A cholesterol transporter ABCA5 that is encoded in the genome of human.


name: S29A3_HUMAN Equilibrative nucleoside transporter 3 (sprot)

description: An equilibrative nucleoside transporter 3 that is encoded in the genome of human.


name: S15A3_HUMAN Solute carrier family 15 member 3 (sprot)

description: A solute carrier family 15 member 3 that is encoded in the genome of human.


name: TPC2_HUMAN Two pore channel protein 2 (sprot)

description: A two pore channel protein 2 that is encoded in the genome of human.


name: TPC1_HUMAN Two pore channel protein 1 (sprot)

description: A two pore channel protein 1 that is encoded in the genome of human.


metallochaperone activity

description: Binding to and delivering metal ions to a target protein.


cyanocobalamin

A complex cob(III)alamin in which cobalt is positioned in the centre of a planar corrin tetrapyrrole ring and bound axially to a 5,6-dimethylbenzimidazole moiety and a cyano group. It is one of several forms of the vitamin known as vitamin B12.


AMNLS_HUMAN Protein amnionless (sprot)

A protein amnionless that is encoded in the genome of human.


gastric emptying

description: The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.


radial pattern formation

description: The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur.


name: LMBD1_HUMAN Lysosomal cobalamin transport escort protein LMBD1 (sprot)

description: A lysosomal cobalamin transport escort protein LMBD1 that is encoded in the genome of human.


name: MA2B2_HUMAN Epididymis-specific alpha-mannosidase (sprot)

description: An epididymis-specific alpha-mannosidase that is encoded in the genome of human.


NEUR4_HUMAN Sialidase-4 (sprot)

A sialidase-4 that is encoded in the genome of human.


name: PPT2_HUMAN Lysosomal thioesterase PPT2 (sprot)

description: A lysosomal thioesterase PPT2 that is encoded in the genome of human.


name: AT132_HUMAN Polyamine-transporting ATPase 13A2 (sprot)

description: A polyamine-transporting ATPase 13A2 that is encoded in the genome of human.


regulation of vitamin metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


insulin receptor binding

description: Binding to an insulin receptor.


methionine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.


name: LN28A_HUMAN Protein lin-28 homolog A (sprot)

description: A protein lin-28 homolog A that is encoded in the genome of human.


flavin adenine dinucleotide

A flavin adenine dinucleotide in which the substituent at position 10 of the flavin nucleus is a 5'-adenosyldiphosphoribityl group.


taurolithocholic acid sulfate

The steroid sulfate of taurolithocholic acid.


benzoic acid

A compound comprising a benzene ring core carrying a carboxylic acid substituent.


phytanic acid

A branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15.


N-Acetylglucosamine

An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.


ACETYLGLUTAMIC ACID

An N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group.


cobalt atom

A cobalt group element atom that has atomic number 27.


coenzyme A

A thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit.


FERULATE

A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring.


FK506-binding protein 15

A protein that is a translation product of the human FKBP15 gene or a 1:1 ortholog thereof.


thyroid hormone

Any hormone produced by the thyroid gland


clofibrate

The ethyl ester of clofibric acid.


A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.


CAPTAN

A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops.


TRIPHENYL PHOSPHATE

An  aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol.


propylparaben

The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid.   Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.


chelator

A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.


A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.


haloperidol

A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.


AMITROLE

A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.


FENRETINIDE

A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.


An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.


niclosamide

A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.


LUPEOL

A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables.


22,23-dihydroavermectin B1a

A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.


GLYPHOSATE

A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).


thiomersal

An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.


TETRAC

A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.


benzoquinone

The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.


perfluorohexanesulfonic acid

A perfluoroalkanesulfonic acid that is hexane-1-sulfonic acid in which all thirteen of the hydrogens that are attached to carbons have been replaced by fluorines.


acetylcysteine

An  N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.


diisobutyl phthalate

A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of isobutanol.


carbon nanotube

A molecule consisting of a graphene cylinder or two or more concentric graphene cylinders.


isoprenaline

A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.


perfluorononanoic acid

A fluoroalkanoic acid that is nonanoic acid in which all of the hydrogens in the alkyl chain are replaced by fluorines.


FURAN

A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.


gentamicin

Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.


PYRACLOSTROBIN

A carbamate ester that is the methyl ester of [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]methoxycarbamic acid. A fungicide used to control major plant pathogens including Septoria tritici, Puccinia spp. and Pyrenophora teres.


ellagic acid

An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.


name: PENTABROMODIPHENYL ETHER (MIXED ISOMERS)


clioquinol

A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.


chlorogenic acid

A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is an intermediate metabolite in the biosynthesis of lignin.


A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.


fenfluramine

A  secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.


ouabain

A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.


resorcinol

A  benzenediol that is benzene dihydroxylated at positions 1 and 3.


bis(2-chloroethyl) sulfide

An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.


nickel sulfate

A metal sulfate having nickel(2+) as the metal ion.


dasatinib monohydrate

A hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).


rifampicin

A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).


titanium dioxide

A titanium oxide with the formula TiO2.  A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.


fulvestrant

A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.


ALLITRIDIN

An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity


zoledronic acid

An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.


tetracycline

A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.


flavonoid

Any member of the 'superclass' flavonoids whose skeleton is based on 1-benzopyran with an aryl substituent at position 2. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.


ciglitazone

An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.


FIPRONIL

A racemate comprising equimolar amounts of (R)- and (S)-fipronil.


procymidone

An azabicycloalkane that is 1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione in which the amino hydrogen is replaced by a 3,5-dichlorophenyl group. A fungicide widely used in horticulture as a seed dressing, pre-harvest spray or post-harvest dip for the control of various diseases.


mebendazole

A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.


nitrososulfamethoxazole

A sulfonamide compound having a 4-nitrosophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.


nimesulide

An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.


PYRAZOLE

The 1H-tautomer of pyrazole.


A bromophenol that is phenol in which the hydrogens at positions 2, 4 and 6 have been replaced by bromines. It is commonly used as a fungicide and in the preparation of flame retardants.


rimonabant

A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation.


perfluorooctane-1-sulfonic acid

A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.


stearic acid

A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and  plastics.


heparin

A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.


clofibric acid

A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.


herbicide

A substance used to destroy plant pests.


dipropyl phthalate

A phthalate ester that is the dipropyl ester of benzene-1,2-dicarboxylic acid.


catechin

The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.


gallic acid

A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5.


piperine

A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.


promegestone

A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.


METRIBOLONE

A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.


MANGIFERIN

A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.


miconazole

A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.


clotrimazole

A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.


monoisononyl phthalate

A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of isononanol.


rigosertib

An N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties.


oleanolic acid

A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.


amlexanox

A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.


microcystin-LR

A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.


BENZO[E]PYRENE

An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.


Phe-Ser

A dipeptide that is the N-(L-phenylalanyl) derivative of L-serine.


IPRODIONE

An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide.


perfluorohexanoic acid

A monocarboxylic acid that is perfluorinated hexanoic acid.


CYPRODINIL

A member of the class of aminopyrimidine that is N-phenylpyrimidin-2-amine carrying additional cyclopropyl and methyl substituents at positions 4 and 6 respectively. A broad spectrum fungicide used to control a range of pathogens including Tapesia yallundae, Botrytis spp., Alternaria spp. and Rhynchospium secalis. Whilst it is a recognised irritant no serious human health concerns have been identified. It is moderately toxic to birds as well as most aquatic organisms and earthworms, but it is not considered toxic to honeybees.


DCMU

A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.


picene

An ortho-fused polycyclic arene consisting of five fused benzene rings. It is obtained during the distillation of petroleum.


demethoxycurcumin

A beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior.


hydrazines

Hydrazine (diazane) and its substituted derivatives.


DINITROPHENYLENE

A dinitrobenzene that is benzene disubstituted at positions 1 and 3 with nitro groups.


tolcapone

Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase.


CYPROCONAZOLE

A diastereoisomeric mixture composed of the enantiomeric pair (2R,3S)- and (2S,3R)-cyproconazole in ratio 1:1 with the enantiomeric pair (2R,3R)- and (2S,3S)-cyproconazole. A broad spectrum fungicide, it is used on cereals and other field crops used to control Septoria, rust, powdery mildew and other diseases.


BENZAMIDE

An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.


nevirapine

A dipyridodiazepine that is  5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.


MYCLOBUTANIL

A racemate comprising equimolar amounts of (R)- and (S)-myclobutanil. A sterol demethylation inhibitor, it is a widely-used agricultural fungicide.


BROMOBENZENE

The simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30degreeC; b.p.760 156degreeC), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis.


reserpine

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.


bethanechol

The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.


tris(2-butoxyethyl) phosphate

A trialkyl phosphate in which the alkyl group specified is 2-butoxyethyl.


estradiol benzoate

A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.


ZINC CHLORIDE

A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.


deferoxamine

An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.


oxybenzone

A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.


DOCETAXEL

The trihydrate form of  docetaxel. It is used for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.


hemin

It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.


methyl p-hydroxybenzoate

A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blueberries.


PROCYANIDIN B2

A proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 8' in a beta-configuration. Procyanidin B2 can be found in Cinchona pubescens (Chinchona, in the rind, bark and cortex), in Cinnamomum verum (Ceylon cinnamon, in the rind, bark and cortex), in Crataegus monogyna (Common hawthorn, in the flower and blossom), in Uncaria guianensis (Cat's claw, in the root), in Vitis vinifera (Common grape vine, in the leaf), in Litchi chinensis (litchi, in the pericarp), in the apple, in Ecdysanthera utilis and in red wine.


perfluorodecanoic acid

A fluoroalkanoic acid that is perfluorinated decanoic acid.


enzalutamide

A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.


entacapone

A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5-nitrophenyl group.


succimer

A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.


nitrofurazone

A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.


mianserin

A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.


phenoxyacetic acid

A monocarboxylic acid that is the O-phenyl derivative of glycolic acid. A metabolite of 2-phenoxyethanol, it is used in the manufacture of pharmaceuticals, pesticides, fungicides and dyes.


citalopram

A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer,  escitalopram. It is used as an antidepressant, although only escitalopram is active.


A monocarboxylic acid that is 2-(phenylsulfanyl)isobutyric acid in which the phenyl group is substituted at the para- position by a 3-aza-7-cyclohexylhept-1-yl group in which the nitrogen is acylated by a (cyclohexylamino)carbonyl group.


tris(2-chloroethyl) phosphate

A trialkyl phosphate that is the tris(2-chloroethyl) ester of phosphoric acid.


PYRENE

An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.


CHLORPYRIFOS-METHYL

An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.


naphthoquinone

A polycyclic aromatic ketone metabolite of naphthalene.


THIOPHANATE

A member of the class of thioureas that is the diethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould.


ethyl hydroxybenzoate

An ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol,


A benzodioxine that is idazoxan substituted at position 2 by a methoxy group.


Sudan III

A bis(azo) compound that is 2-naphthol substituted at position 1 by a 4-{[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections.


picrotoxinin

A picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin.


alvocidib

A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.


MPEP

A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.


glyoxal

The dialdehyde that is the smallest possible and which consists of ethane having oxo groups on both carbons.


zinc sulfate

A metal sulfate compound having zinc(2+) as the counterion.


pesticide

Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.


PICEATANNOL

A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.


donepezil

A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.


An aminotoluene that is para-toluidine with an additional amino group at position 2.


BETA-NAPHTHOFLAVONE

An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.


2-bromophenyl 2,4-dibromophenyl ether

A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 2', and 4 positions have been replaced by bromines.


name: POLYINOSINIC-POLYCYTIDYLIC ACID (HIGH MW)


CYCLOHEXANOL

An alcohol that consists of cyclohexane bearing a single hydroxy substituent. The parent of the class of cyclohexanols.


pilocarpine

The (+)-enantiomer of pilocarpine.


dimercaprol

A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.


chromium atom

A chromium group element atom that has atomic number 24.


biomarker

A substance used as an indicator  of a biological state.


dichlorvos

An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.


A monohydroxyflavanone in which the hydroxy group is located at position 3'.


2,4,5-TRICHLOROPHENOXYACETIC ACID

A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2, 4 and 5 are substituted by chlorines.


morin

A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.


MELITTIN

A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.


beryllium sulfate

A metal sulfate in which the metal is beryllium (in the +2 oxidation state) and the ratio of beryllium  to sulfate is 1:1.


masoprocol

The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.


apilimod

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 in IFNg/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs. Apilimod is a potent and highly selective PIKfyve inhibitor.


DOI

An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.


TEBUCONAZOLE

A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops.


PROCHLORAZ

A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.


HYDROCHLORTHIAZIDE

An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom.


PYRROLIDINE DITHIOCARBAMATE

A member of the class of dithiocarbamic acids that is the N-dithiocarboxy derivative of pyrrolidine.


DIETHYL PHTHALATE

The diethyl ester of benzene-1,2-dicarboxylic acid.


isoflavones

Any isoflavonoid with a 3-aryl-1-benzopyran-4-one (3-aryl-4H-chromen-4-one) skeleton and its substituted derivatives.


tiratricol

A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.


terbutaline

A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.


KT 5720

An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3-carboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol-2-one.


aminoacridine

Acridines which are substituted in any position by one or more amino groups or substituted amino groups. Note that the term 'aminoacridine' is the International Prorietary Name (INN) for 9-aminoacridine.


betulinic acid

A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.


pomalidomide

An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.


A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.


MANGOSTIN

A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.


pyrrolizidine alkaloid

An alkaloid based on the structure of pyrrolizidine.


FENITROTHION

An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.


tiotropium bromide

An organic bromide salt having (1alpha,2beta,4beta,5alpha,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane as the counterion. Used (in the form of the hydrate) for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.


clomipramine

A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.


procaine

A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.


name: insecticidal crystal protein, Bacillus Thuringiensis


A secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4degreeC, boiling point 174degreeC at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose.


OCTANAL

A saturated fatty aldehyde formally arising from reduction of the carboxy group of caprylic acid (octanoic acid).


tributyl phosphate

A trialkyl phosphate that is the tributyl ester of phosphoric acid.


A member of the class of 1-benzothiophenes that is raloxifene in which the piperidin-1-yl group has been replaced by a pyrrolidin-1-yl group.


sotalol

A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.


BISDEMETHOXYCURCUMIN

A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.


OXIDOPAMINE

A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).


TEMPO

A member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and  methyl groups at positions 2, 2, 6, and 6, respectively.


phenylarsine oxide

An arsine oxide derived from phenylarsine.


A dichlorophenol that is phenol carrying chloro substituents at positions 2 and 4.


bicalutamide

A member of the class of (trifluoromethyl)benzenes that is 4-amino-2-(trifluoromethyl)benzonitrile in which one of the amino hydrogens is substituted by a 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoyl group.


chalcones

A ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.


telmisartan

A member of the class of  benzimidazoles  used widely in the treatment of hypertension.


3',5'-cyclic UMP

A 3',5'-cyclic pyrimidine nucleotide having uridine as the nucleobase.


ISOLIQUIRITIGENIN

A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.


sotorasib

A pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations.


name: 2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester


NEUROTENSIN

A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.


pterostilbene

A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.


tartrazine

An organic sodium salt which is the trisodium salt of tartrazine acid. A synthetic lemon yellow azo dye used as a food colouring.


IOXYNIL

A  nitrile that is benzonitrile substituted by a hydroxy group at position 4 and iodo groups at positions 3 and 5.


A member of the class of fluorenes that is 9H-fluorene in which both of the hydrogens at position 9 have been replaced by p-hydroxyphenyl groups.


norethisterone

A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.


A hydroxyether that is ethanol substituted by a methoxy group at position 2.


A substituted aniline that is benzamide in which one of the meta- hydrogens is replaced by an amino group.


budesonide

A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.


A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphoryl)thio group.


An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.


stavudine

A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase


endrin

An organochlorine compound resulting from the epoxidation of the double bond of isodrin. It is the endo, endo stereoisomer of dieldrin. It is an insecticide mainly used on field crops such as cotton and grains and has also been used as a rodenticide to control mice and voles. The product is banned in many countries since it is a persistent organic pollutant.


PROPANIL

An anilide resulting from the formal condensation of the carboxy group of propanoic acid with the amino group of 3,4-dichloroaniline. It is a herbicide used for the treatment of numerous grasses and broad-leaved weeds in rice, potatoes, and wheat.