name: K2C72_HUMAN Keratin, type II cytoskeletal 72 (sprot)

description: A keratin, type II cytoskeletal 72 that is encoded in the genome of human.


name: K1H1_HUMAN Keratin, type I cuticular Ha1 (sprot)

description: A keratin, type I cuticular Ha1 that is encoded in the genome of human.


name: K1C24_HUMAN Keratin, type I cytoskeletal 24 (sprot)

description: A keratin, type I cytoskeletal 24 that is encoded in the genome of human.


name: KR251_HUMAN Keratin-associated protein 25-1 (sprot)

description: A keratin-associated protein 25-1 that is encoded in the genome of human.


name: KR213_HUMAN Keratin-associated protein 21-3 (sprot)

description: A keratin-associated protein 21-3 that is encoded in the genome of human.


name: KR192_HUMAN Keratin-associated protein 19-2 (sprot)

description: A primate-type keratin-associated protein 19-2 that is encoded in the genome of human.


name: KR198_HUMAN Keratin-associated protein 19-8 (sprot)

description: A keratin-associated protein 19-8 that is encoded in the genome of human.


name: KR211_HUMAN Keratin-associated protein 21-1 (sprot)

description: A keratin-associated protein 21-1 that is encoded in the genome of human.


name: KR212_HUMAN Keratin-associated protein 21-2 (sprot)

description: A keratin-associated protein 21-2 that is encoded in the genome of human.


name: KR202_HUMAN Keratin-associated protein 20-2 (sprot)

description: A keratin-associated protein 20-2 that is encoded in the genome of human.


name: KR201_HUMAN Keratin-associated protein 20-1 (sprot)

description: A keratin-associated protein 20-1 that is encoded in the genome of human.


name: KRA61_HUMAN Keratin-associated protein 6-1 (sprot)

description: A keratin-associated protein 6-1 that is encoded in the genome of human.


name: KRA62_HUMAN Keratin-associated protein 6-2 (sprot)

description: A keratin-associated protein 6-2 that is encoded in the genome of human.


name: KRA63_HUMAN Keratin-associated protein 6-3 (sprot)

description: A keratin-associated protein 6-3 that is encoded in the genome of human.


name: KR196_HUMAN Keratin-associated protein 19-6 (sprot)

description: A keratin-associated protein 19-6 that is encoded in the genome of human.


name: KR195_HUMAN Keratin-associated protein 19-5 (sprot)

description: A keratin-associated protein 19-5 that is encoded in the genome of human.


name: KR194_HUMAN Keratin-associated protein 19-4 (sprot)

description: A keratin-associated protein 19-4 that is encoded in the genome of human.


name: KR151_HUMAN Keratin-associated protein 15-1 (sprot)

description: A keratin-associated protein 15-1 that is encoded in the genome of human.


name: KR134_HUMAN Keratin-associated protein 13-4 (sprot)

description: A keratin-associated protein 13-4 that is encoded in the genome of human.


name: KR271_HUMAN Keratin-associated protein 27-1 (sprot)

description: A keratin-associated protein 27-1 that is encoded in the genome of human.


name: KR241_HUMAN Keratin-associated protein 24-1 (sprot)

description: A keratin-associated protein 24-1 that is encoded in the genome of human.


name: KR221_HUMAN Keratin-associated protein 22-1 (sprot)

description: A keratin-associated protein 22-1 that is encoded in the genome of human.


name: KR133_HUMAN Keratin-associated protein 13-3 (sprot)

description: A keratin-associated protein 13-3 that is encoded in the genome of human.


name: K2C71_HUMAN Keratin, type II cytoskeletal 71 (sprot)

description: A keratin, type II cytoskeletal 71 that is encoded in the genome of human.


name: KR197_HUMAN Keratin-associated protein 19-7 (sprot)

description: A keratin-associated protein 19-7 that is encoded in the genome of human.


name: KR132_HUMAN Keratin-associated protein 13-2 (sprot)

description: A keratin-associated protein 13-2 that is encoded in the genome of human.


name: K2C79_HUMAN Keratin, type II cytoskeletal 79 (sprot)

description: A keratin, type II cytoskeletal 79 that is encoded in the genome of human.


name: K1C40_HUMAN Keratin, type I cytoskeletal 40 (sprot)

description: A keratin, type I cytoskeletal 40 that is encoded in the genome of human.


name: K1C39_HUMAN Keratin, type I cytoskeletal 39 (sprot)

description: A keratin, type I cytoskeletal 39 that is encoded in the genome of human.


name: K2C80_HUMAN Keratin, type II cytoskeletal 80 (sprot)

description: A keratin, type II cytoskeletal 80 that is encoded in the genome of human.


name: KR511_HUMAN Keratin-associated protein 5-11 (sprot)

description: A keratin-associated protein 5-11 that is encoded in the genome of human.


name: KR510_HUMAN Keratin-associated protein 5-10 (sprot)

description: A keratin-associated protein 5-10 that is encoded in the genome of human.


name: KRA57_HUMAN Keratin-associated protein 5-7 (sprot)

description: A keratin-associated protein 5-7 that is encoded in the genome of human.


name: KRA56_HUMAN Keratin-associated protein 5-6 (sprot)

description: A keratin-associated protein 5-6 that is encoded in the genome of human.


name: KRA54_HUMAN Keratin-associated protein 5-4 (sprot)

description: A keratin-associated protein 5-4 that is encoded in the genome of human.


name: KRA53_HUMAN Keratin-associated protein 5-3 (sprot)

description: A keratin-associated protein 5-3 that is encoded in the genome of human.


name: KRA51_HUMAN Keratin-associated protein 5-1 (sprot)

description: A keratin-associated protein 5-1 that is encoded in the genome of human.


name: KR261_HUMAN Keratin-associated protein 26-1 (sprot)

description: A keratin-associated protein 26-1 that is encoded in the genome of human.


name: KRA55_HUMAN Keratin-associated protein 5-5 (sprot)

description: A keratin-associated protein 5-5 that is encoded in the genome of human.


name: KRA52_HUMAN Keratin-associated protein 5-2 (sprot)

description: A keratin-associated protein 5-2 that is encoded in the genome of human.


name: K2C74_HUMAN Keratin, type II cytoskeletal 74 (sprot)

description: A keratin, type II cytoskeletal 74 that is encoded in the genome of human.


name: K1C28_HUMAN Keratin, type I cytoskeletal 28 (sprot)

description: A keratin, type I cytoskeletal 28 that is encoded in the genome of human.


name: K1C27_HUMAN Keratin, type I cytoskeletal 27 (sprot)

description: A keratin, type I cytoskeletal 27 that is encoded in the genome of human.


name: K1C26_HUMAN Keratin, type I cytoskeletal 26 (sprot)

description: A keratin, type I cytoskeletal 26 that is encoded in the genome of human.


name: K1C25_HUMAN Keratin, type I cytoskeletal 25 (sprot)

description: A keratin, type I cytoskeletal 25 that is encoded in the genome of human.


name: KR193_HUMAN Keratin-associated protein 19-3 (sprot)

description: A keratin-associated protein 19-3 that is encoded in the genome of human.


name: K2C1B_HUMAN Keratin, type II cytoskeletal 1b (sprot)

description: A keratin, type II cytoskeletal 1b that is encoded in the genome of human.


name: K2C73_HUMAN Keratin, type II cytoskeletal 73 (sprot)

description: A keratin, type II cytoskeletal 73 that is encoded in the genome of human.


name: KR191_HUMAN Keratin-associated protein 19-1 (sprot)

description: A keratin-associated protein 19-1 that is encoded in the genome of human.


name: KR131_HUMAN Keratin-associated protein 13-1 (sprot)

description: A keratin-associated protein 13-1 that is encoded in the genome of human.


name: KR111_HUMAN Keratin-associated protein 11-1 (sprot)

description: A keratin-associated protein 11-1 that is encoded in the genome of human.


name: KRA81_HUMAN Keratin-associated protein 8-1 (sprot)

description: A keratin-associated protein 8-1 that is encoded in the genome of human.


name: KRA13_HUMAN Keratin-associated protein 1-3 (sprot)

description: A keratin-associated protein 1-3 that is encoded in the genome of human.


name: K2C78_HUMAN Keratin, type II cytoskeletal 78 (sprot)

description: A keratin, type II cytoskeletal 78 that is encoded in the genome of human.


name: KRT35_HUMAN Keratin, type I cuticular Ha5 (sprot)

description: A keratin, type I cuticular Ha5 that is encoded in the genome of human.


name: K1C12_HUMAN Keratin, type I cytoskeletal 12 (sprot)

description: A keratin, type I cytoskeletal 12 that is encoded in the genome of human.


name: KR171_HUMAN Keratin-associated protein 17-1 (sprot)

description: A keratin-associated protein 17-1 that is encoded in the genome of human.


name: KRA99_HUMAN Keratin-associated protein 9-9 (sprot)

description: A keratin-associated protein 9-9 that is encoded in the genome of human.


name: KRA98_HUMAN Keratin-associated protein 9-8 (sprot)

description: A keratin-associated protein 9-8 that is encoded in the genome of human.


name: KRA94_HUMAN Keratin-associated protein 9-4 (sprot)

description: A keratin-associated protein 9-4 that is encoded in the genome of human.


name: KRA93_HUMAN Keratin-associated protein 9-3 (sprot)

description: A keratin-associated protein 9-3 that is encoded in the genome of human.


name: KRA92_HUMAN Keratin-associated protein 9-2 (sprot)

description: A keratin-associated protein 9-2 that is encoded in the genome of human.


name: KRA46_HUMAN Keratin-associated protein 4-6 (sprot)

description: A keratin-associated protein 4-6 that is encoded in the genome of human.


name: KR411_HUMAN Keratin-associated protein 4-11 (sprot)

description: A keratin-associated protein 4-11 that is encoded in the genome of human.


name: KRA41_HUMAN Keratin-associated protein 4-1 (sprot)

description: A keratin-associated protein 4-1 that is encoded in the genome of human.


name: KRA49_HUMAN Keratin-associated protein 4-9 (sprot)

description: A keratin-associated protein 4-9 that is encoded in the genome of human.


name: KRA48_HUMAN Keratin-associated protein 4-8 (sprot)

description: A keratin-associated protein 4-8 that is encoded in the genome of human.


name: KRA47_HUMAN Keratin-associated protein 4-7 (sprot)

description: A keratin-associated protein 4-7 that is encoded in the genome of human.


name: KRA45_HUMAN Keratin-associated protein 4-5 (sprot)

description: A keratin-associated protein 4-5 that is encoded in the genome of human.


name: KRA44_HUMAN Keratin-associated protein 4-4 (sprot)

description: A keratin-associated protein 4-4 that is encoded in the genome of human.


name: KRA43_HUMAN Keratin-associated protein 4-3 (sprot)

description: A keratin-associated protein 4-3 that is encoded in the genome of human.


name: KRA42_HUMAN Keratin-associated protein 4-2 (sprot)

description: A keratin-associated protein 4-2 that is encoded in the genome of human.


name: KRA33_HUMAN Keratin-associated protein 3-3 (sprot)

description: A keratin-associated protein 3-3 that is encoded in the genome of human.


name: KRA32_HUMAN Keratin-associated protein 3-2 (sprot)

description: A keratin-associated protein 3-2 that is encoded in the genome of human.


name: KRA31_HUMAN Keratin-associated protein 3-1 (sprot)

description: A keratin-associated protein 3-1 that is encoded in the genome of human.


name: KRA24_HUMAN Keratin-associated protein 2-4 (sprot)

description: A keratin-associated protein 2-4 that is encoded in the genome of human.


name: KRA15_HUMAN Keratin-associated protein 1-5 (sprot)

description: A keratin-associated protein 1-5 that is encoded in the genome of human.


name: KRA22_HUMAN Keratin-associated protein 2-2 (sprot)

description: A keratin-associated protein 2-2 that is encoded in the genome of human.


name: KRA21_HUMAN Keratin-associated protein 2-1 (sprot)

description: A keratin-associated protein 2-1 that is encoded in the genome of human.


name: K1C23_HUMAN Keratin, type I cytoskeletal 23 (sprot)

description: A keratin, type I cytoskeletal 23 that is encoded in the genome of human.


name: KRT84_HUMAN Keratin, type II cuticular Hb4 (sprot)

description: A keratin, type II cuticular Hb4 that is encoded in the genome of human.


name: KRT82_HUMAN Keratin, type II cuticular Hb2 (sprot)

description: A keratin, type II cuticular Hb2 that is encoded in the genome of human.


regulation of hormone metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone.


opioid peptide activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.


name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback

description: The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.


name: efferent axon development in a lateral line nerve

description: The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve.


name: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis

description: The process in which a lung bud bifurcates perpendicular to the plane of the previous bud.


name: planar dichotomous subdivision of terminal units involved in lung branching morphogenesis

description: The process in which a lung bud bifurcates parallel to the plane of the previous bud.


muscular septum morphogenesis

description: The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.


kidney morphogenesis

description: Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


name: establishment of planar polarity involved in neural tube closure

description: Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


name: planar cell polarity pathway involved in heart morphogenesis

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart.


name: gamma-aminobutyric acid:proton antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out).


lobar bronchus epithelium development

description: The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus.


name: VMAT1_HUMAN Chromaffin granule amine transporter (sprot)

description: A chromaffin granule amine transporter that is encoded in the genome of human.


JUN kinase binding

description: Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.


RNA polymerase binding

description: Binding to an RNA polymerase molecule or complex.


name: inositol trisphosphate phosphatase activity

description: Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate.


name: MD1L1_MOUSE Mitotic spindle assembly checkpoint protein MAD1 (sprot)

description: A mitotic spindle assembly checkpoint protein MAD1 that is encoded in the genome of mouse.


AURKC_MOUSE Aurora kinase C (sprot)

An aurora kinase C that is encoded in the genome of mouse.


name: positive regulation of protein autoubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.


sodium channel regulator activity

description: Binds to and modulates the activity of a sodium channel.


name: regulation of sodium ion transmembrane transporter activity

description: Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.


mu-type opioid receptor binding

description: Binding to a mu-type opioid receptor.


name: B7ZJH6_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

description: A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH6.


name: sigma non-opioid intracellular receptor 1 isoform m2 (mouse)

description: A sigma non-opioid intracellular receptor 1 isoform 3 that is encoded in the genome of mouse.


name: B7ZJH7_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

description: A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH7.


name: B7ZJH9_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

description: A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH9.


name: B7ZJH8_MOUSE Sigma non-opioid intracellular receptor 1 (trembl)

description: A sigma non-opioid intracellular receptor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:B7ZJH8.


name: negative regulation of hepatocyte proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation.


hyperplasia

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement.


steroid dehydrogenase activity

description: Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.


TYROSOL

A phenol substituted at position 4 by a 2-hydroxyethyl group.


A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.


A member of the class of  quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an  epidermal growth factor receptor antagonist.


sorbinil

An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.


TROLOX

A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures.


amorolfine

A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.


hydroxytyrosol

A member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities.


A member of the class of  pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor, it exhibits anticancer property.


oleuropein

A secoiridoid glycoside that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the anomeric hydroxy group at position 2 has been converted into its beta-D-glucoside and the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2S,3E,4S stereoisomer). The most important phenolic compound present in olive cultivars.


name: Grayanotoxane-5,6,10,14,16-pentol, 2,3-epoxy-, 6-acetate, (2beta,3beta,6beta,14R)-(9CI)


etodolac

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.


butenafine

Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.


SCALARADIAL

A scalarane sesterterpenoid with formula C27H40O4. It is a natural product found in the marine sponges Spongia officinalis and Cacospongia mollior, and exhibits anti-inflammatory activity.


MANOALIDE

A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2.


telomere cap complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.


name: negative regulation of apoptotic DNA fragmentation

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation.


name: negative regulation of retinal cone cell fate commitment

description: Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell.


retinal rod cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye.


name: negative regulation of amacrine cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation.


lamin binding

description: Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.


lamin filament

description: Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.


name: H60B_MOUSE Histocompatibility antigen 60b (sprot)

description: A protein that is a translation product of the H60b gene in mouse.


MHC class I protein binding

description: Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


MHC class Ib receptor activity

description: Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


name: HA12_MOUSE H-2 class I histocompatibility antigen, D-D alpha chain (sprot)

description: An H-2 class I histocompatibility antigen D1 alpha chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01900.


name: HA1D_MOUSE H-2 class I histocompatibility antigen, K-D alpha chain (sprot)

description: An H-2 class I histocompatibility antigen K1 alpha chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01902.


name: MFSD6_MOUSE Major facilitator superfamily domain-containing protein 6 (sprot)

description: A major facilitator superfamily domain-containing protein 6 that is encoded in the genome of mouse.


developmental cell growth

description: The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.


acylglycerol metabolic process

description: The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


dolichol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.


protein mannosylation

description: The addition of a mannose residue to a protein acceptor molecule.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.


name: regulation of Rho guanyl-nucleotide exchange factor activity

description: Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.


hyaloid vascular plexus regression

description: The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression.


name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

description: Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


regulation of tube size

description: Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes.


nephron tubule morphogenesis

description: The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


uterus morphogenesis

description: The process in which anatomical structures of the uterus are generated and organized.


mesonephric tubule development

description: The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros.


kidney rudiment formation

description: The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


metanephric tubule formation

description: The developmental process pertaining to the initial formation of a metanephric tubule.


male genital tubercle

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A differentiated genital tubercle that is part of a male reproductive system.


name: membrane depolarization during SA node cell action potential

description: The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


name: voltage-gated calcium channel activity involved SA node cell action potential

description: Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: positive regulation of mitochondrial membrane permeability involved in apoptotic process

description: Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process.


name: positive regulation of retinoic acid receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.


retinoic acid binding

description: Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.


name: positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway.


regulation of growth hormone activity

description: Any process that modulates the frequency, rate or extent of growth hormone activity.


name: regulation of spongiotrophoblast cell proliferation

description: Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation.


ammonium transmembrane transport

description: The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.


transition between slow and fast fiber

description: The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.


amylase activity

description: Catalysis of the hydrolysis of amylose or an amylose derivative.


Tie signaling pathway

description: The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


plasma membrane fusion

description: The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.


white matter of spinal cord

description: The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.


description: The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.


name: negative regulation of zinc ion transmembrane transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other.


name: TNR18_HUMAN Tumor necrosis factor receptor superfamily member 18 (sprot)

description: A tumor necrosis factor receptor superfamily member 18 that is encoded in the genome of human.


name: CTLA4_HUMAN Cytotoxic T-lymphocyte protein 4 (sprot)

description: A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human.


D3 dopamine receptor binding

description: Binding to a D3 dopamine receptor.


name: negative regulation of adenylate cyclase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.


name: DRD3_MOUSE D(3) dopamine receptor (sprot)

description: A D(3) dopamine receptor that is encoded in the genome of mouse.


cullin-RING ubiquitin ligase complex

description: Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


metal ion binding

description: Binding to a metal ion.


detoxification of copper ion

description: Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion.


cellular response to chromate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus.


name: regulation of systemic arterial blood pressure by hormone

description: The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.


renal tubular secretion

description: The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.


name: positive regulation of estrogen secretion

description: Any process that activates or increases the frequency, rate or extent of estrogen secretion.


sperm annulus

description: The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.


name: clathrin-sculpted acetylcholine transport vesicle membrane

description: The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle.


name: APBA1_HUMAN Amyloid-beta A4 precursor protein-binding family A member 1 (sprot)

description: An amyloid-beta A4 precursor protein-binding family A member 1 that is encoded in the genome of human.


name: CSKP_HUMAN Peripheral plasma membrane protein CASK (sprot)

description: A peripheral plasma membrane protein CASK that is encoded in the genome of human.


name: LIN7B_HUMAN Protein lin-7 homolog B (sprot)

description: A protein lin-7 homolog B that is encoded in the genome of human.


name: LIN7A_HUMAN Protein lin-7 homolog A (sprot)

description: A protein lin-7 homolog A that is encoded in the genome of human.


name: LIN7C_HUMAN Protein lin-7 homolog C (sprot)

description: A protein lin-7 homolog C that is encoded in the genome of human.


An oxoicosatetraenoic acid having a 12-oxo group; and (5Z)-, (8Z), (10E)- and (14Z)-double bonds.


cyclin K-CDK13 complex

description: A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


MYH9_MOUSE Myosin-9 (sprot)

A myosin-9 that is encoded in the genome of mouse.


isoleucine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.


L-leucine metabolic process

description: The chemical reactions and pathways involving L-leucine, 2-amino-4-methylpentanoic acid.


valine metabolic process

description: The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.


isoleucine metabolic process

description: The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.


atrial septum primum morphogenesis

description: The process in which anatomical structure of an atrial septum primum is generated and organized.


atrial septum secundum morphogenesis

description: The process in which anatomical structure of an atrial septum secundum is generated and organized.


name: insulin-like growth factor binding protein complex

description: A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development.


name: regulation of acyl-CoA biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.


regulation of locomotion

description: Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.


localization within membrane

description: Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.


odorant binding

description: Binding to an odorant, any substance capable of stimulating the sense of smell.


medullary thymic epithelial cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.


name: regulation of ventricular cardiac muscle cell membrane depolarization

description: Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte.


name: positive regulation of striated muscle tissue development

description: Any process that activates or increases the frequency, rate or extent of striated muscle development.


milk ejection reflex

description: A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness.


IgE immunoglobulin complex, circulating

description: A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


neural plate axis specification

description: The pattern specification process in which the axes of the nervous system are established.


name: negative regulation of cell proliferation involved in contact inhibition

description: Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density.


name: development of primary female sexual characteristics

description: The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.


IgM binding

description: Binding to an immunoglobulin of the IgM isotype.


name: immunoglobulin transcytosis in epithelial cells

description: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.


paranasal sinus

description: The paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity.


macromolecule catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.


protein depalmitoylation

description: The removal of palymitoyl groups from a lipoprotein.


name: negative regulation of phosphatase activity

description: Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.


immunoglobulin receptor binding

description: Binding to one or more specific sites on an immunoglobulin receptor molecule.


name: T cell differentiation involved in immune response

description: The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.


CCR4-NOT complex

description: The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.


name: PDXL2_HUMAN Podocalyxin-like protein 2 (sprot)

description: A podocalyxin-like protein 2 that is encoded in the genome of human.


somatic cell DNA recombination

description: Recombination occurring within or between DNA molecules in somatic cells.


name: planar cell polarity pathway involved in cardiac right atrium morphogenesis

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium.


name: KLRB1_MOUSE Killer cell lectin-like receptor subfamily B member 1 (sprot)

description: A killer cell lectin-like receptor subfamily B member 1G that is encoded in the genome of mouse.


olfactory lobe development

description: The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.


dendritic growth cone

description: The migrating motile tip of a growing nerve cell dendrite.


sarcoplasmic reticulum lumen

description: The volume enclosed by the membranes of the sarcoplasmic reticulum.


name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


leukotriene B4 receptor activity

description: Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.


CXCR4 chemokine receptor binding

description: Binding to a CXCR4 chemokine receptor.


peroxiredoxin activity

description: Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.


filopodium membrane

description: The portion of the plasma membrane surrounding a filopodium.


AQP7_HUMAN Aquaporin-7 (sprot)

An aquaporin-7 that is encoded in the genome of human.


AQP9_HUMAN Aquaporin-9 (sprot)

An aquaporin-9 that is encoded in the genome of human.


Roundabout binding

description: Binding to Roundabout (ROBO) receptor, a transmembrane receptor.


dorsal/ventral axon guidance

description: The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.


spleen trabecula formation

description: The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.


response to iron ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.


gonad morphogenesis

description: The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.


anoctamin-7 isoform 1 (mouse)

An anoctamin-7 isoform 1 that is encoded in the genome of mouse.


name: regulation of sodium-dependent phosphate transport

description: Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport.


name: CD99 antigen-like protein 2 isoform m2 (mouse)

description: A CD99 antigen-like protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BIF0-2.


name: CD99 antigen-like protein 2 isoform m1 (mouse)

description: A CD99 antigen-like protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BIF0-1.


name: nucleoside triphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.


name: nucleoside diphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


glycosphingolipid

A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid.


A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the tetrasaccharide component.


name: SUMF2_HUMAN Inactive C-alpha-formylglycine-generating enzyme 2 (sprot)

description: An inactive C-alpha-formylglycine-generating enzyme 2 that is encoded in the genome of human.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide; major species at pH 7.3.


A sialotriaosylceramide consisting of the pentasaccharide beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc attached to the primary hydroxy function of ceramide.


An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GT2; major species at pH 7.3.


An N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide in which the ceramide N-acyl group is specified as stearoyl.


An organosulfate oxoanion obtained by deprotonation of the sulfate group of N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide; major species at pH 7.3.


snRNA binding

description: Binding to a small nuclear RNA (snRNA).


name: cyclin/CDK positive transcription elongation factor complex

description: A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.


adenyl deoxyribonucleotide binding

description: Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


cellular response to type I interferon

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


name: generation of precursor metabolites and energy

description: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.


immune complex formation

description: The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus.


DNA modification

description: The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.


name: T cell antigen processing and presentation

description: The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.


CD86 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival.


name: DNA synthesis involved in UV-damage excision repair

description: Any DNA synthesis that is involved in UV-damage excision repair.


name: single stranded viral RNA replication via double stranded DNA intermediate

description: A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II.


deoxyribonuclease II activity

description: Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.


oxalic acid secretion

description: The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue.


glyoxylate

The conjugate base of glyoxylic acid.


description: An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.


COP9 signalosome

description: A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.


bronchus morphogenesis

description: The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs.


name: negative regulation of meiotic cell cycle phase transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition.


prostaglandin F receptor activity

description: Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.


name: positive regulation of myotome development

description: Any process that activates or increases the frequency, rate or extent of myotome development.


oncostatin-M receptor activity

description: Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


N-acetyl-alpha-D-galactosamine

An N-acetyl-D-galactosamine having alpha-configuration at the anomeric centre.


carbohydrate derivative binding

description: Binding to a carbohydrate derivative.


name: negative regulation of actin filament severing

description: Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing.


name: positive regulation of actin filament severing

description: Any process that activates or increases the frequency, rate or extent of actin filament severing.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol.


tRNA 2'-phosphotransferase activity

description: Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.


isoprenoid binding

description: Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.


structural constituent of tooth enamel

description: The action of a molecule that contributes to the structural integrity of tooth enamel.


name: positive regulation of oxidoreductase activity

description: Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.


name: glial cell-derived neurotrophic factor receptor binding

description: A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


name: microglial cell activation involved in immune response

description: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


ectoderm and mesoderm interaction

description: A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm.


cloacal septation

description: The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development.


heterotypic cell-cell adhesion

description: The attachment of a cell to a cell of a different type via adhesion molecules.


name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity

description: Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.


copper ion transmembrane transport

description: The directed movement of copper cation across a membrane.


description: Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).


protein arginylation

description: The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.


name: negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

description: Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I.


filamin binding

description: Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


inner cell mass cell fate commitment

description: The cell fate commitment of precursor cells that will become inner cell mass cells.


name: positive regulation of epidermal growth factor-activated receptor activity

description: Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity.


name: positive regulation of complement-dependent cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity.


PeBoW complex

description: A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.


pancreatic juice secretion

description: The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.


RNA-DNA hybrid ribonuclease activity

description: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.


name: negative regulation of asymmetric cell division

description: Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.


fibular nerve

description: Any nerve that innervates the fibularis. Includes the common fibular nerve, and its branches.


septin collar

description: A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.


name: DNA ligation involved in DNA recombination

description: The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination.


DNA ligation involved in DNA repair

description: The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.


intestinal lipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas.


detection of virus

description: The series of events in which a stimulus from a virus is received and converted into a molecular signal.


name: DNA-binding transcription repressor activity

description: A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.


tripeptidyl-peptidase activity

description: Catalysis of the release of an N-terminal tripeptide from a polypeptide.


name: regulation of monoatomic anion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cerebrospinal fluid secretion

description: The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces.


Cul5-RING ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


name: regulation of arginine metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


description: The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate.


lipid kinase activity

description: Catalysis of the phosphorylation of a simple or complex lipid.


name: regulation of mesenchymal cell proliferation

description: Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


name: AKAP5_MOUSE A-kinase anchor protein 5 (sprot)

description: An A-kinase anchor protein 5 that is encoded in the genome of mouse.


name: establishment of protein localization to membrane

description: The directed movement of a protein to a specific location in a membrane.


description: The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.


phosphocreatine metabolic process

description: The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle.


phosphocreatine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.


beta-D-fructofuranose 6-phosphate

A D-fructofuranose 6-phosphate with a beta-configuration at the anomeric position.


L-glutamic acid

An optically active form of glutamic acid having L-configuration.


D-glucosamine 6-phosphate

A glucosamine phosphate that is D-glucosamine substituted by a phosphate group at position 6.


name: negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

description: Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


pheromone activity

description: The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant.


name: CSF3R_MOUSE Granulocyte colony-stimulating factor receptor (sprot)

description: A granulocyte colony-stimulating factor receptor that is encoded in the genome of mouse.


name: granulocyte colony-stimulating factor receptor activity

description: Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


description: Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.


ANSERINE

A dipeptide comprising of beta-alanine and 3-methyl-L-histidine units.


carnosine

A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.


L-cystathionine dizwitterion

Dizwitterionic form of L-cystathionine arising from transfer of two protons from the carboxy to the amino groups; major species at pH 7.3.


A 2-oxo monocarboxylic acid anion that is the conjugate base of 2-oxobutanoic acid, obtained by deprotonation of the carboxy group.


name: macrophage colony-stimulating factor receptor binding

description: Binding to a macrophage colony-stimulating factor receptor.


dTTP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.


angiotensin type II receptor activity

description: An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.


diplotene

description: The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.


TRAIL binding

description: Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.


noelin isoform 1 (mouse)

A noelin isoform 1 that is encoded in the genome of mouse.


noelin isoform 2 (mouse)

A noelin isoform 2 that is encoded in the genome of mouse. This isoform has Gly at position 153, and the C-terminal region 154-485 is missing.


name: regulation of dendritic spine development

description: Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


name: glycine decarboxylation via glycine cleavage system

description: The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.


name: PACR_MOUSE Pituitary adenylate cyclase-activating polypeptide type I receptor (sprot)

description: A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of mouse.


name: negative regulation of vascular endothelial growth factor receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


name: cytoplasmic sequestering of transcription factor

description: The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.


BRCA2-BRAF35 complex

description: A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.


NEDD8 activating enzyme activity

description: Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.


endomitotic cell cycle

description: A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.


name: cellular response to triacyl bacterial lipopeptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus.


name: detection of triacyl bacterial lipopeptide

description: The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.


diacyl lipopeptide binding

description: Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups.


name: detection of diacyl bacterial lipopeptide

description: The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.


name: positive regulation of lymphocyte apoptotic process

description: Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.


oocyte differentiation

description: The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.


response to organonitrogen compound

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.


fever generation

description: The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.


regulation of CD40 signaling pathway

description: Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway.


hedgehog family protein binding

description: Binding to a member of the hedgehog protein family, signaling proteins involved in development.


L-phenylalanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.


name: negative regulation of osteoclast development

description: Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.


name: positive regulation of protein-containing complex assembly

description: Any process that activates or increases the frequency, rate or extent of protein complex assembly.


CPNE6_HUMAN Copine-6 (sprot)

A copine-6 that is encoded in the genome of human.


CPNE7_HUMAN Copine-7 (sprot)

A copine-7 that is encoded in the genome of human.


actin filament severing

description: The process in which an actin filament is broken down into smaller filaments.


bilirubin conjugation

description: The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin.


glycitein 4'-O-glucuronide

A glycosyloxyisoflavone that is the glucuronide-conjugated form of the phytoestrogen glycitein.


name: chloride:monoatomic cation symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).


chloride transmembrane transport

description: The process in which chloride is transported across a membrane.


ribosomal protein S6 kinase activity

description: Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.


name: non-kinase phorbol ester receptor activity

description: Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.


name: synaptic vesicle, readily releasable pool

description: A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton.


seminal vesicle morphogenesis

description: The process in which the anatomical structures of a seminal vesicle are generated and organized.


poly-pyrimidine tract binding

description: Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule.


histone H3 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.


name: histone H4K12 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12).


dynactin complex

description: A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.


female meiosis II

description: The cell cycle process in which the second meiotic division occurs in the female germline.


name: positive regulation of mononuclear cell migration

description: Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.


sensory perception of chemical stimulus

description: The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


motor learning

description: Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience.


name: negative regulation of Golgi to plasma membrane protein transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.


peptidoglycan immune receptor activity

description: Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response.


name: biological process involved in interaction with host

description: An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.


name: negative regulation of natural killer cell differentiation involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


name: regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.


negative regulation of endocytosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.


name: negative regulation of mitotic cell cycle phase transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition.


cytosine

An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4.


subcortical maternal complex

description: Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex.


name: porphyrin-containing compound metabolic process

description: The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.


name: sequence-specific single stranded DNA binding

description: Binding to single-stranded DNA of a specific nucleotide composition.


cAMP binding

description: Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).


name: positive regulation of dendritic cell antigen processing and presentation

description: Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.


nitrite transport

description: The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of T-helper 1 type immune response

description: Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.


prostaglandin transport

description: The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


yolk sac cavity

description: An anatomical cavity that is part of a yolk sac [Automatically generated definition].


leukotriene D4 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of leukotriene D4.


nucleolar ribonuclease P complex

description: A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.


7S RNA binding

description: Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).


regulation of ruffle assembly

description: Any process that modulates the frequency, rate or extent of ruffle assembly.


meiotic spindle elongation

description: The lengthening of the distance between poles of the spindle during a meiotic cell cycle.


name: establishment of integrated proviral latency

description: A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.


DNA integration

description: The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.


name: cell surface pattern recognition receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.


negative regulation of ERK5 cascade

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


tricellular tight junction

description: An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.


name: MALD2_MOUSE MARVEL domain-containing protein 2 (sprot)

description: A MARVEL domain-containing protein 2 that is encoded in the genome of mouse.


name: regulation of motor neuron apoptotic process

description: Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.


positive regulation of p38MAPK cascade

description: Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.


protein polymerization

description: The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.


glucosamine metabolic process

description: The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.


long-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


icosa-5,8,11,14-tetraenoic acid

Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.


negative regulation of feeding behavior

description: Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.


name: negative regulation of brown fat cell proliferation

description: Any process that stops or decreases the rate or extent of brown fat cell proliferation.


phosphatidylinositol phosphate binding

description: Binding to phosphatidylinositol phosphate.


positive regulation of heat generation

description: Any process that activates or increases the rate or extent of heat generation.


very long-chain fatty acid

A fatty acid which has a chain length greater than C22. Very long-chain fatty acids which have a chain length greater than C27 are also known as ultra-long-chain fatty acids.


very long-chain fatty acyl-CoA

A fatty acyl-CoA in which the fatty acyl group has a chain length greater than C22.


name: very long-chain fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


regulation of interleukin-10 production

description: Any process that modulates the frequency, rate, or extent of interleukin-10 production.


cytokinin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.


name: regulation protein catabolic process at presynapse

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.


name: G protein-coupled glutamate receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


name: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

description: The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.


name: CD4-positive, alpha-beta T cell activation

description: The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


name: negative regulation by host of viral process

description: A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected.


Peyer's patch morphogenesis

description: The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.


name: visceral mesoderm-endoderm interaction involved in midgut development

description: The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut.


name: pyramidal neuron migration to cerebral cortex

description: The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex.


name: negative regulation of apoptotic process involved in outflow tract morphogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.


FZD4_HUMAN Frizzled-4 (sprot)

A frizzled-4 that is encoded in the genome of human.


FZD5_HUMAN Frizzled-5 (sprot)

A frizzled-5 that is encoded in the genome of human.


FZD2_HUMAN Frizzled-2 (sprot)

A frizzled-2 that is encoded in the genome of human.


name: negative regulation of high voltage-gated calcium channel activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity.


name: negative regulation of tubulin deacetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.


name: monocyte activation involved in immune response

description: The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


granulosa cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals.


regulation of vesicle fusion

description: Any process that modulates the frequency, rate or extent of vesicle fusion.


name: positive regulation of dendritic cell chemotaxis

description: Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.


name: modification-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.


alcohol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.


quinone metabolic process

description: The chemical reactions and pathways involving quinone.


COPII vesicle coat

description: One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.


name: regulation of cargo loading into COPII-coated vesicle

description: Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle.


name: regulation of establishment of planar polarity involved in neural tube closure

description: Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


dopamine receptor binding

description: Binding to a dopamine receptor.


regulation of renal phosphate excretion

description: Any process that modulates the frequency, rate or extent of renal phosphate excretion.


integrin alphaIIb-beta3 complex

description: An integrin complex that comprises one alphaIIb subunit and one beta3 subunit.


lipopolysaccharide metabolic process

description: The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.


acyloxyacyl hydrolase activity

description: Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.


asparagine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.


name: positive regulation of catecholamine secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.


parturition

description: The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.


name: negative regulation of dendritic cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.


name: positive regulation of dendritic cell differentiation

description: Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.


conventional dendritic cell

description: Conventional dendritic cell is a dendritic cell that is CD11c-high.


PDYN_HUMAN Proenkephalin-B (sprot)

A proenkephalin-B that is encoded in the genome of human.


name: large ribosomal subunit protein uL13, initiator methionine removed acetylated and phosphorylated 1 (mouse)

description: A large ribosomal subunit protein uL13, initiator methionine removed acetylated and phosphorylated 1 in mouse. Phosphorylation occurs upon activation of the DAPK-ZIPK cascade. UniProtKB:P19253, 2-203, Ala-2, MOD:00050|Ser-77, MOD:00046.


U5 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes.


bile canaliculus

description: An intercellular channel that takes up bile from hepatocytes, transporting it to the bile ducts.


name: proton motive force-driven ATP synthesis

description: The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.


threonine racemase activity

description: Catalysis of the reaction: L-threonine = D-threonine.


D-serine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine.


L-methionine (R)-S-oxide

The (R)-oxido diastereomer of L-methionine S-oxide.


L-methionine sulfone

An L-methionine derivative in which the sulfur has been oxidised to the corresponding sulfone.


L-beta-isoaspartate residue

An anionic amino-acid residue formed following deamidation of L-asparagine or dehydration of L-aspartate residue.


name: GLCM1_MOUSE Glycosylation-dependent cell adhesion molecule 1 (sprot)

description: A glycosylation-dependent cell adhesion molecule 1 that is encoded in the genome of mouse.


organic anion transport

description: The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.


name: positive regulation of miRNA transcription

description: Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription.


regulation of lung blood pressure

description: The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure.


name: negative regulation of striated muscle cell apoptotic process

description: Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.


name: regulation of vascular endothelial growth factor production

description: Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.


name: regulation of platelet-derived growth factor production

description: Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: tertiary branching involved in mammary gland duct morphogenesis

description: The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy.


name: negative regulation of dephosphorylation

description: Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.


name: regulation of translational initiation in response to stress

description: Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress.


name: positive regulation of circadian sleep/wake cycle, sleep

description: Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.


name: positive regulation of leukocyte apoptotic process

description: Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.


name: SCUB1_HUMAN Signal peptide, CUB and EGF-like domain-containing protein 1 (sprot)

description: A signal peptide, CUB and EGF-like domain-containing protein 1 that is encoded in the genome of human.


phenotypic switching

description: A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.


cGMP binding

description: Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).


name: intracellularly cGMP-activated cation channel activity

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.


description: Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP.


L-lysine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid.


name: regulation of calcium ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport.


name: protein C-terminal carboxyl O-methyltransferase activity

description: Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein.


C-terminal protein methylation

description: The methylation of the C-terminal amino acid of a protein.


regulation of cell division

description: Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.


peptide metabolic process

description: The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.


nucleotide-excision repair complex

description: Any complex formed of proteins that act in nucleotide-excision repair.


interleukin-27 receptor binding

description: Binding to an interleukin-27 receptor.


vitamin E binding

description: Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


name: TTPA_HUMAN Alpha-tocopherol transfer protein (sprot)

description: An alpha-tocopherol transfer protein that is encoded in the genome of human.


NADPH oxidase 1 isoform 2 (mouse)

An NADPH oxidase 1 isoform 2 that is encoded in the genome of mouse.


NOX3_MOUSE NADPH oxidase 3 (sprot)

An NADPH oxidase 3 that is encoded in the genome of mouse.


phosphatase regulator activity

description: Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.


name: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.


involuntary skeletal muscle contraction

description: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control.