Group I intron splicing

description: The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize).


name: siderophore-iron transmembrane transporter activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).


siderophore metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.


coenzyme A transport

description: The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.


description: Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A.


name: cyclic threonylcarbamoyladenosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


mitochondrial seryl-tRNA aminoacylation

description: The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


name: arginine biosynthetic process via ornithine

description: The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.


prolyl-tRNA aminoacylation

description: The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.


name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae.


NatA complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.


name: N-terminal protein amino acid propionylation

description: The propionylation of the N-terminal amino acid of proteins.


name: mitochondrial processing peptidase complex

description: A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion.


homoserine kinase activity

description: Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+.


homoserine metabolic process

description: The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.


myosin II tail binding

description: Binding to the tail region of a myosin II heavy chain.


proline catabolic process to glutamate

description: The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.


2-deoxyglucose-6-phosphatase activity

description: Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.


inositol phosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


intracellular cobalt ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of cobalt (Co2+) ions within a cell.


detoxification of cadmium ion

description: Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion.


Vma12-Vma22 assembly complex

description: A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p.


name: vacuolar proton-transporting V-type ATPase complex assembly

description: The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.


2-dehydropantoate 2-reductase activity

description: Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH.


Cdc42 protein signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal.


description: Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.


tRNA N1-guanine methylation

description: The process whereby a guanine in tRNA is methylated at position N1 of the guanine.


name: regulation of translation in response to stress

description: Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


rixosome complex

description: A conserved RNA endonuclease complex required for spreading and epigenetic inheritance of heterochromatin. The rixosome contains six unique subunits: three structural subunits (Crb3, Rix1, and Ipi1) which form the core of the complex, and three catalytic subunits (the endonuclease Las1, the polynucleotide kinase Grc3, and the AAA-type ATPase Mdn1), which are involved in the processing of ribosomal RNA precursors. All subunits are essential for viability and are conserved from yeast to mammals, including humans.


Ste12p-Dig1p-Dig2p complex

description: A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae.


nuclear cap binding complex

description: A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.


name: piccolo histone acetyltransferase complex

description: A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.


description: The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


name: pentose transmembrane transporter activity

description: Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms.


mannose transmembrane transport

description: The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.


name: [cytochrome c]-lysine N-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c.


D-xylose reductase (NADPH) activity

description: Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+.


URM1 activating enzyme activity

description: Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond.


name: dinucleotide insertion or deletion binding

description: Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion.


description: Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil.


pyrimidine-containing compound salvage

description: Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.


intermediate layer of spindle pole body

description: Structure between the central and outer plaques of the spindle pole body.


protein autosumoylation

description: The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.


kynurenine aminotransferase activity

description: Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid.


description: Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.


L-phenylalanine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.


dUMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).


name: negative regulation of mitotic cytokinesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis.


mRNA 3'-splice site recognition

description: Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.


name: THO complex part of transcription export complex

description: The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.


nucleoplasmic THO complex

description: The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits.


inner plaque of spindle pole body

description: One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus.


name: positive regulation of cytoplasmic translation

description: Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.


name: microtubule nucleation by spindle pole body

description: The 'de novo' formation of a microtubule, mediated by the spindle pole body.


GPI-anchor transamidase complex

description: An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor.


endoplasmic reticulum tubular network

description: A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section.


name: regulation of cardiolipin metabolic process

description: Any process that modulates the frequency, rate or extent of cardiolipin metabolic process.


exopolyphosphatase activity

description: Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.


guanine salvage

description: Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis.


name: cytosolic [4Fe-4S] assembly scaffold complex

description: A heterotetrameric complex with weak ATPase activity that is capable of scaffolding a 4Fe-4S (iron-sulfur) cluster. In yeast, the subunits are Nbp35 and Cfd1. In humans, the subunits are NUBP1 and NUBP2.


4 iron, 4 sulfur cluster binding

description: Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.


name: pyruvate secondary active transmembrane transporter activity

description: Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


name: PAM complex, Tim23 associated import motor

description: Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.


name: regulation of transcription by RNA polymerase III

description: Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.


cellular response to carbon dioxide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.


nuclear SCF ubiquitin ligase complex

description: A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).


name: negative regulation of SNARE complex assembly

description: Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


name: regulation of synaptonemal complex assembly

description: Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed.


UBR1-RAD6 ubiquitin ligase complex

description: A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.


name: ubiquitin-dependent protein catabolic process via the N-end rule pathway

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.


regulation of dipeptide transport

description: Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: nuclear mRNA surveillance of mRNA 3'-end processing

description: The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus.


name: regulation of invasive growth in response to glucose limitation

description: Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation.


homoisocitrate dehydrogenase activity

description: Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.


description: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine.


rRNA base methylation

description: The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.


glucan 1,4-alpha-glucosidase activity

description: Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.


name: peptidyl-histidine methylation, to form tele-methylhistidine

description: The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).


nitrite reductase (NO-forming) activity

description: Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.


name: negative regulation of phospholipid translocation

description: Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


cellular response to acetate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus.


name: MAP kinase tyrosine phosphatase activity

description: Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate.


nuclear pore cytoplasmic filaments

description: Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component.


pantoate-beta-alanine ligase activity

description: Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.


name: histidine phosphotransfer kinase activity

description: Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator.


protein histidine kinase activity

description: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.


protein histidine kinase binding

description: Binding to a protein histidine kinase.


name: carbon catabolite regulation of transcription from RNA polymerase II promoter

description: A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.


name: promoter-terminator loop anchoring activity

description: Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop.


nitrilase activity

description: Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.


inulinase activity

description: Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin.


inulin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of inulin.


fructan catabolic process

description: The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues.


raffinose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside.


sulfoacetic acid

A carboxyalkanesulfonic acid that is the C-sulfo derivative of acetic acid.


sulfur compound transport

description: The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: sulfur compound transmembrane transporter activity

description: Enables the transfer of a sulfur compound from one side of a membrane to the other.


isethionate

The alkanesulfonate that is the anion formed from isethionic acid by loss of a proton from the sulfo group; major microspecies at pH 7.3.


oligo-1,6-glucosidase activity

description: Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose.


DNA/RNA helicase activity

description: Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis.


negative regulation of strand invasion

description: Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


CST complex

description: A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection.


RES complex

description: A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p.


steryl-beta-glucosidase activity

description: Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol.


name: ergosteryl 3-beta-D-glucoside catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside.


RNA folding

description: The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure.


DNA primase activity

description: Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer.


name: high-affinity zinc transmembrane transporter activity

description: Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


Cbf1-Met4-Met28 complex

description: A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation.


mitochondrial RNA processing

description: The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.


signal peptidase complex

description: A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space.


INA complex

description: A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p.


name: positive regulation of urea catabolic process

description: Any process that activates or increases the frequency, rate or extent of urea catabolic process.


name: positive regulation of gamma-aminobutyric acid catabolic process

description: Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process.


mitotic checkpoint complex

description: A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20.


name: deactivation of mitotic spindle assembly checkpoint

description: A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint.


name: regulation of mitotic metaphase/anaphase transition

description: Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


category: biolink:MacromolecularComplex biolink:MacromolecularMachineMixin biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: allantoin:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport.


allantoin transport

description: The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


malate synthase activity

description: Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+.


name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

description: The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8).


name: inositol phosphoceramide synthase complex

description: A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces).


name: inositol phosphoceramide synthase activity

description: Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol.


name: positive regulation of proline catabolic process to glutamate

description: Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate.


name: mitochondrial proton-transporting ATP synthase, stator stalk

description: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.


peptide pheromone maturation

description: The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae.


description: A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.


protein farnesyltransferase complex

description: A protein complex that possesses protein farnesyltransferase activity.


description: Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.


UMP/dUMP kinase activity

description: Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.


PAN complex

description: A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.


transcription factor TFIIE complex

description: A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH.


name: maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II

description: Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.


biotin synthase activity

description: Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H+.


malic enzyme activity

description: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.


regulation of ribosome biogenesis

description: Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


UDP-glucose metabolic process

description: The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.


centromere complex assembly

description: The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere.


name: positive regulation of maintenance of meiotic sister chromatid cohesion

description: Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle.


meiotic sister chromatid separation

description: The process in which sister chromatids are physically detached from each other during meiosis.


nuclear pore outer ring

description: A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).


description: Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin.


cellular detoxification of aldehyde

description: Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


pre-mRNA branch point binding

description: Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site.


description: A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces.


cellular birth scar

description: Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation.


response to furfural

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus.


name: DNA replication preinitiation complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity.


sequence-specific DNA binding, bending

description: The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


name: negative regulation of conjugation with cellular fusion

description: Any process that decreases the rate or frequency of conjugation with cellular fusion.


name: RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending

description: Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.


name: malonate(1-) transmembrane transporter activity

description: Enables the transfer of malonate(1-) from one side of a membrane to the other.


name: isopropylmalate transmembrane transporter activity

description: Enables the transfer of isopropylmalate from one side of a membrane to the other.


name: oxaloacetate transmembrane transporter activity

description: Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other.


oxaloacetate transport

description: The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


isopropylmalate transport

description: The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


MALONIC ACID

An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.


glucose 1-phosphate metabolic process

description: The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1.


name: glycerol transmembrane transporter activity

description: Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


arsenite transport

description: The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


polyol transmembrane transport

description: The directed movement of polyols, any polyhydric alcohol, across a membrane.


acid-amino acid ligase activity

description: Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


name: transcription initiation at RNA polymerase III promoter

description: A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.


name: positive regulation of ubiquitin-dependent endocytosis

description: Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis.


name: S-methylmethionine transmembrane transporter activity

description: Enables the transfer of S-methylmethionine from one side of a membrane to the other.


S-methylmethionine transport

description: The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: L-isoleucine transmembrane transporter activity

description: Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid.


name: RNA lariat debranching enzyme activator activity

description: Binds to and increases the activity of an RNA lariat debranching enzyme.


name: signal recognition particle receptor complex

description: A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex.


signal recognition particle binding

description: Binding to a signal recognition particle.


protein phosphatase 2B binding

description: Binding to a protein phosphatase 2B.


polyamine transport

description: The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


FNIP-folliculin RagC/D GAP

description: A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2.


name: mating-type a-factor pheromone receptor activity

description: Combining with the mating-type a-factor pheromone to initiate a change in cell activity.


Golgi vesicle docking

description: The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane.


putrescine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine.


mitochondrial [2Fe-2S] assembly complex

description: A protein complex capable of forming 2Fe-2S clusters in mitochondria. In humans it consists of ISCU, NFS1, LYRM4, NDUFAB1 and FXN.


acyl carrier activity

description: Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.


protein phosphatase activator activity

description: Binds to and increases the activity of a protein phosphatase.


description: The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


spermine transport

description: The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: mitochondrial intermembrane space protein transporter complex

description: Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane.


description: Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.


description: Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate.


name: cellular modified amino acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.


name: selenite:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).


name: secondary active monocarboxylate transmembrane transporter activity

description: Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.


plasma membrane pyruvate transport

description: The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane.


plasma membrane lactate transport

description: The directed movement of lactate across a plasma membrane.


regulation of intracellular transport

description: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.


name: U2-type post-mRNA release spliceosomal complex

description: A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs.


exomer complex

description: A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues.


name: nitrogen catabolite repression of transcription

description: A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


sedoheptulose-bisphosphatase activity

description: Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate.


ribose phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar.


phospholipid dephosphorylation

description: The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


name: tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent

description: Catalysis of the reaction: S-adenosyl-L-methionine + uridine54 in tRNA = 5-methyluridine54 in tRNA + H+ + S-adenosyl-L-homocysteine.


name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


description: Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2.


maturation of 5.8S rRNA

description: Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.


name: negative regulation of hydrogen peroxide-mediated programmed cell death

description: Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.


purine nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.


name: 3'-tRNA processing endoribonuclease activity

description: Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.


name: assembly of large subunit precursor of preribosome

description: The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.


snRNA modification

description: The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA.


RNA exon ligation

description: The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction.


snRNA metabolic process

description: The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.


mitochondrial protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure.


Dom34-Hbs1 complex

description: A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay.


name: dipeptide transmembrane transporter activity

description: Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.


name: tripeptide transmembrane transporter activity

description: Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other.


dipeptide transport

description: The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


tripeptide transport

description: The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


pyridoxine metabolic process

description: The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


glycerone kinase activity

description: Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.


name: glycerol to glycerone phosphate metabolic process

description: The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate.


clathrin-coated vesicle cargo loading

description: Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle.


name: mitochondrial DNA-directed RNA polymerase complex

description: A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.


name: transcription elongation by mitochondrial RNA polymerase

description: The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase.


Golgi vesicle budding

description: The evagination of the Golgi membrane, resulting in formation of a vesicle.


pre-mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).


COPII-coated vesicle budding

description: The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


name: cyclin-dependent protein kinase activating kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).


phosphatidylinositol deacylase activity

description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+.


protein-lipid complex remodeling

description: The acquisition, loss or modification of a protein or lipid within a protein-lipid complex.


aminoacyl-tRNA editing activity

description: The hydrolysis of an incorrectly aminoacylated tRNA.


name: nitrogen catabolite activation of transcription

description: A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


valine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.


L-leucine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid.


name: proteasome core complex import into nucleus

description: The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus.


nuclear pore linkers

description: A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p).


PAS complex

description: A phosphatidylinositol kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKFYVE in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.


MutSgamma complex

description: A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5.


name: positive regulation of vacuole organization

description: Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.


sulfite reductase complex (NADPH)

description: A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide.


sulfite reductase (NADPH) activity

description: Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+.


name: negative regulation of meiotic DNA double-strand break formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation.


half bridge of spindle pole body

description: Structure adjacent to the plaques of the spindle pole body.


name: negative regulation of kinetochore assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of kinetochore assembly.


fructose import across plasma membrane

description: The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.


name: L-cysteine catabolic process to pyruvate

description: The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate.


protein-transporting ATPase activity

description: Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.


proteasome-activating activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.


rRNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.


name: histone H2AQ104 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to Q105 in yeast.


box C/D sno(s)RNA 3'-end processing

description: Any process involved in forming the mature 3' end of a box C/D RNA molecule.


intracellular accumulation of glycerol

description: The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment.


name: positive regulation of microtubule nucleation

description: Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


name: mitochondrial tRNA wobble position uridine thiolation

description: The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.


detection of sucrose stimulus

description: The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal.


sucrose mediated signaling

description: The series of molecular signals mediated by the detection of sucrose.


FAD biosynthetic process

description: The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide.


name: peroxisome membrane targeting sequence binding

description: Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane.


ER-dependent peroxisome organization

description: A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum.


NADH regeneration

description: A metabolic process that generates a pool of NADH by the reduction of NAD+.


name: positive regulation of glycolytic fermentation to ethanol

description: Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol.


regulation of SNARE complex assembly

description: Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


carboxymethylenebutenolidase activity

description: Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate.


NADH dehydrogenase activity

description: Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.


name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex

description: A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p.


name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex

description: A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p.


name: regulation of purine nucleobase metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines.


name: regulation of histidine biosynthetic process

description: Any process that modulates the frequency, rate or extent of histidine biosynthetic process.


name: tRNA (guanine) methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine.


transcription factor TFIIK complex

description: A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.


secondary cell septum biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division.


glycine import into mitochondrion

description: The process in which glycine is transported from the cytosol into the mitochondrial matrix.


iron chaperone activity

description: Directly binding to and delivering iron ions to a target protein.


description: Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester.


alpha-keto amide reductase activity

description: Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic.


alpha-keto ester reductase activity

description: Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic.


cellular ketone metabolic process

description: The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


amide metabolic process

description: The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.


homocitrate synthase activity

description: Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate.


RAVE complex

description: A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.


description: Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase).


description: Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).


name: negative regulation of mitochondrial fusion

description: Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.


phosphatidic acid transfer activity

description: Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3.


Noc4p-Nop14p complex

description: A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.


lactate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of lactate.


Pho85-Pho80 CDK-cyclin complex

description: A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin.


name: negative regulation of calcium-mediated signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling.


name: negative regulation of phosphate metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.


name: hydroxymethylfurfural reductase (NADH) activity

description: Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+.


furaldehyde metabolic process

description: The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass.


guanine nucleotide transport

description: The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


tRNA (m7G46) methyltransferase complex

description: A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat).


name: endoplasmic reticulum tubular network maintenance

description: The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section.


inositol hexakisphosphate binding

description: Binding to inositol hexakisphosphate.


D-tyrosyl-tRNA(Tyr) deacylase activity

description: Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA.


D-leucyl-tRNA(Leu) deacylase activity

description: Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu).


D-tyrosine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-tyrosine.


tRNA metabolic process

description: The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.


D-leucine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-leucine.


division septum assembly

description: The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.


phosphoglycolate phosphatase activity

description: Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate.


xylitol transmembrane transport

description: The directed movement of a xylitol across a membrane. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose.


description: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.


RNA polymerase III core binding

description: Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.


name: negative regulation of maintenance of mitotic sister chromatid cohesion

description: Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle.


GINS complex

description: A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.


name: regulation of inositol phosphate biosynthetic process

description: Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


FAL1-SGD1 complex

description: A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits.


name: positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine

description: Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine.


oligosaccharide binding

description: Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.


mitochondrial tRNA 5'-end processing

description: The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.


name: trehalose metabolism in response to stress

description: The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.


ubiquitin conjugating enzyme complex

description: Any complex that possesses ubiquitin conjugating enzyme activity.


name: single base insertion or deletion binding

description: Binding to a double-stranded DNA region containing a single base insertion or deletion.


D-ribulokinase activity

description: Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate.


iron-sulfur cluster binding

description: Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.


description: Catalysis of the reaction: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H+ + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine.


name: rDNA spacer replication fork barrier binding

description: Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription.


replication fork arrest at rDNA repeats

description: A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer.


name: positive regulation of DNA recombination

description: Any process that activates or increases the frequency, rate or extent of DNA recombination.


description: Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate.


3-dehydroquinate dehydratase activity

description: Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O.


name: shikimate 3-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.


3-dehydroquinate synthase activity

description: Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate.


shikimate kinase activity

description: Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+.


name: positive regulation of IRE1-mediated unfolded protein response

description: Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response.


clathrin vesicle coat

description: A clathrin coat found on a vesicle.


cyclosporin A binding

description: Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.


description: Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.


name: Ric1-Rgp1 guanyl-nucleotide exchange factor complex

description: A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi.


description: Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + 2 ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + 2 ADP + 2 H+.


name: regulation of arginine catabolic process

description: Any process that modulates the frequency, rate or extent of arginine catabolic process.


name: regulation of arginine biosynthetic process

description: Any process that modulates the frequency, rate or extent of arginine biosynthetic process.


SAS acetyltransferase complex

description: A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p.


positive regulation of vesicle fusion

description: Any process that activates or increases the frequency, rate or extent of vesicle fusion.


name: positive regulation of SNARE complex assembly

description: Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


name: short-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.


RNA strand annealing activity

description: An activity that facilitates the formation of a complementary double-stranded RNA molecule.


Group II intron splicing

description: The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat.


name: negative regulation of cellular response to amino acid starvation

description: Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation.


spore germination

description: The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall).


name: nitrogen catabolite repression of transcription from RNA polymerase II promoter

description: A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.


histone crotonyltransferase activity

description: Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.


homoaconitate hydratase activity

description: Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H2O.


name: positive regulation of heterochromatin formation

description: Any process that activates or increases the frequency, rate or extent of heterochromatin formation.


FMN biosynthetic process

description: The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase.


gluconokinase activity

description: Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+.


anaphase-promoting complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex.


description: Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.


regulation of G1 to G0 transition

description: Any process that modulates the frequency, rate or extent of G1 to G0 transition.


HDA1 complex

description: A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.


name: negative regulation of transcription by competitive promoter binding

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.


asparagine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid.


cytoplasmic side of endosome membrane

description: The side (leaflet) of the endosome membrane that faces the cytoplasm.


snoRNA localization

description: Any process in which small nucleolar RNA is transported to, or maintained in, a specific location.


name: proton-transporting two-sector ATPase complex assembly

description: The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane.


name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

description: All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.


name: RNA polymerase III general transcription initiation factor activity

description: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.


name: inositol phosphoceramide synthase regulator activity

description: Binds to and modulates the activity of inositol phosphoceramide synthase.


NADPH-adrenodoxin reductase activity

description: Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.


description: Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.


phenylpyruvate decarboxylase activity

description: Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2.


name: branched-chain amino acid catabolic process to alcohol via Ehrlich pathway

description: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.


name: methionine catabolic process to 3-methylthiopropanol

description: The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.


SUMO activating enzyme complex

description: A conserved heterodimeric complex with SUMO activating enzyme activity.


uridine nucleosidase activity

description: Catalysis of the reaction: H2O + uridine = ribofuranose + uracil.


name: nicotinic acid riboside hydrolase activity

description: Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose.


name: nicotinamide riboside hydrolase activity

description: Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose.


ribosylpyrimidine nucleosidase activity

description: Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine.


uridine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids.


nicotinate nucleotide salvage

description: The generation of nicotinate nucleotide without de novo synthesis.


cytidine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside.


name: regulation of RNA polymerase II transcription preinitiation complex assembly

description: Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.


adenine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.


septin ring disassembly

description: The controlled breakdown of a septin ring.


name: aromatic amino acid family catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


name: histone H3K79 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein.


endopolyphosphatase activity

description: Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.


GDP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate.


CAAX-box protein processing

description: The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis.


name: protein arginine N5-methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine.


name: spliceosomal conformational changes to generate catalytic conformation

description: Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.


plasmid partitioning

description: Any process in which plasmids are segregated or distributed into daughter cells upon cell division.


description: Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+.


name: myo-inositol transmembrane transporter activity

description: Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.


name: positive regulation of mitotic actomyosin contractile ring contraction

description: Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction.


carbon utilization

description: A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.


long-chain fatty acyl-CoA binding

description: Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


uracil catabolic process

description: The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.


name: solute:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).


ferulate metabolic process

description: The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate.


cinnamic acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid.


aldehyde dehydrogenase (NADP+) activity

description: Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+.


glyoxalase III activity

description: Catalysis of the reaction: methylglyoxal + H2O = D-lactate.


3-isopropylmalate dehydratase activity

description: Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.


fatty acid alpha-oxygenase activity

description: Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid = a 2(R)-hydroperoxy fatty acid.


sphingoid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.


name: proteasome core complex, alpha-subunit complex

description: The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.


tryptophan synthase activity

description: Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O.


name: mRNA cleavage stimulating factor complex

description: A protein complex required for mRNA cleavage but not for poly(A) addition.


name: positive regulation of formation of translation preinitiation complex

description: Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex.


name: eukaryotic translation initiation factor 4F complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex.


name: mitochondrial ribosomal large subunit rRNA binding

description: Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA).


name: mitochondrial large ribosomal subunit assembly

description: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit.


MUB1-RAD6-UBR2 ubiquitin ligase complex

description: A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme.


description: The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes.


name: ethanolamine transmembrane transporter activity

description: Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.


name: (R)-carnitine transmembrane transporter activity

description: Enables the transfer of (R)-carnitine from one side of a membrane to the other.


glycine betaine transport

description: The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


(R)-carnitine transport

description: The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


ethanolamine transport

description: The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine.


name: activation of mitotic cell cycle spindle assembly checkpoint

description: Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint.


name: mannosyl-inositol phosphorylceramide metabolic process

description: The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.


Golgi vesicle fusion to target membrane

description: The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane.


name: positive regulation of DNA-templated transcription initiation

description: Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.


ubiquinone-6 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ubiquinone-6.


mRNA capping enzyme complex

description: A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping.


Dsl1/NZR complex

description: A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p.


riboflavin reductase (NADPH) activity

description: Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.


name: aromatic amino acid family biosynthetic process

description: The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).


chorismate synthase activity

description: Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.


description: Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.


description: Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.


P-type manganese transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate.


meiotic spindle pole body

description: The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.


L-threonylcarbamoyladenylate synthase

description: Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O.


positive regulation of mRNA binding

description: Any process that activates or increases the frequency, rate or extent of mRNA binding.


name: negative regulation of phosphatidylinositol biosynthetic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.


name: vitamin transmembrane transporter activity

description: Enables the transfer of a vitamin from one side of a membrane to the other.


vitamin transport

description: The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


D-serine metabolic process

description: The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.


FACT complex

description: A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage.


regulation of sister chromatid cohesion

description: Any process that modulates the frequency, rate or extent of sister chromatid cohesion.


RNA decapping complex

description: A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA.


pyrimidine nucleobase metabolic process

description: The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


name: GDP-mannose transmembrane transporter activity

description: Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate.


GDP-mannose transmembrane transport

description: The process in which GDP-mannose is transported across a membrane.