name: regulation of calcium ion transport into cytosol

description: Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.


name: regulation of cardiac muscle contraction

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate or extent of cardiac muscle contraction.


name: AFLO_ASPPU Demethylsterigmatocystin 6-O-methyltransferase (sprot)


versicolorin B desaturase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.


name: AFLJ_ASPPU Versiconal hemiacetal acetate esterase (sprot)


name: versiconal hemiacetal acetate esterase activity

description: Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate.


A phenolate anion obtained by deprotonation of the 2-hydroxy group of (S)-averantin. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


averantin hydroxylase activity

description: Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis.


name: norsolorinic acid ketoreductase activity

description: Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH.


name: AFLD_ASPPU Norsolorinic acid ketoreductase (sprot)


name: AFLC_ASPPU Norsolorinic acid synthase (sprot)


versiconal

A secondary metabolite that is an intermediate in the biosynthesis of afflatoxin. Can exist as both a tricyclic anthraquinone-hydroxyaldehyde form or as a tetracyclic anthrafuran form.


norsolorinic acid anthrone(1-)

A phenolate anion obtained by deprotonation of the 2-hydroxy group of norsolorinic acid anthrone. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


A hydroxyanthraquinone that is 1,3,6,8-tetrahydroxy-9,10-anthraquinone bearing a 1,5-dihydroxyhexyl substituent at position 2 (the 1'S,5'R-diastereomer).


name: AFLG_ASPPU Averantin hydroxylase (sprot)


versicolorin A

An organic heteropentacyclic compound that is 3a,12a-dihydroanthra[2,3-b]furo[3,2-d]furan-5,10-dione carrying three hydroxy substituents at positions 4, 6 and 8.


methoxsalen

A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.


aflatoxin

Any of a group of related and highly toxic secondary metabolites (mycotoxins) whose main structural feature is a fused coumarin-bis(dihydrofuran) ring system and which are produced by strains of the moulds Aspergillus flavus or A. parasiticus, together with further metabolites of these mycotoxins


category: biolink:MacromolecularComplex biolink:MacromolecularMachineMixin biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


thiolester hydrolase activity

description: Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.


name: LOVD_ASPTE Monacolin J acid methylbutanoyltransferase (sprot)


name: LOVG_ASPTE Dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase (sprot)


name: TDID_EMENI Aminotransferase tdiD (sprot)


terpene synthase activity

description: Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units.


An organophosphate oxoanion that is the trianion obtained by removal of the three protons from the diphosphate group of 2-trans,6-trans-farnesyl diphosphate.


name: NVFL_ASPN1 Asnovolin H synthase nvfL (sprot)


name: NVFB_ASPN1 DMOA farnesyltransferase nvfB (sprot)


diphosphoric acid

An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid.


name: regulation of fusion of sperm to egg plasma membrane

description: Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane.


name: bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (mouse)

description: A bifunctional glutamate/proline--tRNA ligase (mouse) that has been phosphorylated on a Ser residue in the noncatalytic linker connecting the synthetase cores in an IFN-gamma-dependent manner. UniProtKB:Q8CGC7, Ser-999, MOD:00046.


category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA.


name: positive regulation of guanyl-nucleotide exchange factor activity

description: Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity.


name: regulation of extrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.


snRNA import into nucleus

description: The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus.


RNA import into nucleus

description: The import of RNA from the cytoplasm to the nucleus.


tRNA transport

description: The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: SRP-dependent cotranslational protein targeting to membrane, translocation

description: The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.


name: HMGB2_HUMAN High mobility group protein B2 (sprot)

description: A high mobility group protein B2 that is encoded in the genome of human.


ADP-L-glycero-D-manno-heptose

An ADP-glycero-D-manno-heptose having L-glycero-configuration at the 6-position of the heptose portion.


name: IKIP_HUMAN Inhibitor of nuclear factor kappa-B kinase-interacting protein (sprot)

description: An inhibitor of nuclear factor kappa-B kinase-interacting protein that is encoded in the genome of human.


name: LRC14_HUMAN Leucine-rich repeat-containing protein 14 (sprot)

description: A leucine-rich repeat-containing protein 14 that is encoded in the genome of human.


glomerular endothelial cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate.


name: regulation of striated muscle contraction

description: Any process that modulates the frequency, rate or extent of striated muscle contraction.


phosphatidylcholine binding

description: Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.


T cell receptor complex

description: A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.


leukotriene biosynthetic process

description: The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.


interleukin-3 production

description: The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


serotonin secretion

description: The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.


name: positive regulation of granulocyte macrophage colony-stimulating factor production

description: Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


name: positive regulation of interleukin-3 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-3 production.


beta selection

description: The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.


name: negative regulation of B cell receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.


name: auditory receptor cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


endocrine system development

description: Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.


regulation of cellular respiration

description: Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.


name: negative regulation of fibroblast apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.


description: Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.


name: regulation of thymocyte apoptotic process

description: Any process that modulates the occurrence or rate of thymocyte death by apoptotic process.


cellular response to UV-C

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.


name: T cell proliferation involved in immune response

description: The expansion of a T cell population by cell division as part of an immune response.


negative regulation of miRNA processing

description: Any process that stops, prevents or reduces the frequency, rate or extent of microRNA processing.


name: regulation of fibroblast apoptotic process

description: Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.


name: positive regulation of thymocyte apoptotic process

description: Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process.


hyperosmotic salinity response

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


cyanamide hydratase activity

description: Catalysis of the reaction: urea = cyanamide + H2O.


oxaloacetate metabolic process

description: The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.


name: glutamate catabolic process to aspartate

description: The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate.


name: glutamate catabolic process to 2-oxoglutarate

description: The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.


muscle tendon junction

description: A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons.


name: response to muscle activity involved in regulation of muscle adaptation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation.


box H/ACA snoRNA binding

description: Binding to a box H/ACA small nucleolar RNA.


box H/ACA snoRNP assembly

description: The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex.


snRNA pseudouridine synthesis

description: The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.


EMC complex

description: A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.


EARP complex

description: A quatrefoil tethering complex required for endocytic recycling.


ectodermal cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.


name: embryonic ectodermal digestive tract development

description: The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure.


regulation of oocyte maturation

description: Any process that modulates the frequency, rate or extent of oocyte maturation.


neuronal dense core vesicle lumen

description: The volume enclosed by a neuronal dense core vesicle membrane.


name: regulation of nitric oxide biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.


regulation of protein metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.


name: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

description: The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.


prostate gland stromal morphogenesis

description: The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland.


name: cellular response to insulin-like growth factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.


insulin-like growth factor binding

description: Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.


regulation of lysosomal lumen pH

description: Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


metrifonate

A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.


A organic heterotetracyclic compound that is ellipticine in which the hydrogen at position 9 has been replaced by a hydroxy group.


regulation of motor neuron migration

description: Any process that modulates the frequency, rate or extent of motor neuron migration.


name: regulation of cytokine production involved in immune response

description: Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.


response to tumor necrosis factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


neuron projection arborization

description: The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.


name: nuclear receptor-mediated glucocorticoid signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A nuclear receptor-mediated signaling pathway initiated by a glucocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: regulation of glucocorticoid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


name: ventricular compact myocardium morphogenesis

description: The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.


endocardial cushion cell development

description: The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state.


pyridoxamine 5'-phosphate(1-)

An organophosphate oxoanion that is the conjugate base of pyridoxamine 5'-phosphate.


4-pyridoxic acid

A methylpyridine that is 2-methylpyridine substituted by a hydroxy group at C-3, a carboxy group at C-4, and a hydroxymethyl group at C-5. It is the catabolic product of vitamin B6 and is excreted in the urine.


An ammonium ion that is the conjugate acid of pyridoxamine arising from selective protonation of the primary amino group; major species at pH 7.3.


Nrd1 complex

description: A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.


sno(s)RNA 3'-end processing

description: Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea.


snRNA processing

description: Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres.


fertilization envelope

description: A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release.


regulation of lymphangiogenesis

description: Any process that modulates the frequency, rate or extent of lymphangiogenesis.


meiotic sister chromatid cohesion

description: The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis.


optic chiasma development

description: The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature.


axonal defasciculation

description: Separation of axons away from a bundle of axons known as a fascicle.


regulation of chromosome segregation

description: Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.


microtubule bundle

description: An arrangement of closely apposed microtubules running parallel to each other.


tubulin N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine.


name: regulation of cardiac myofibril assembly

description: Any process that modulates the frequency, rate or extent of cardiac myofibril assembly.


integrin beta-1 isoform beta-1D (mouse)

An integrin beta-1 isoform beta-1D that is encoded in the genome of mouse. This isoform contains a unique alternatively spliced cytoplasmic domain of 50 amino acids, with the last 24 amino acids encoded by an additional exon, 11 of these are in common with the isoform beta-1A.


name: regulation of neural crest cell differentiation

description: Any process that modulates the frequency, rate or extent of neural crest cell differentiation.


nitrite reductase activity

description: Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor.


regulation of centrosome cycle

description: Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.


reflex

description: An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness.


response to cyclophosphamide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus.


response to prostaglandin E

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.


name: behavioral response to acetic acid induced pain

description: Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus.


chronic inflammatory response

description: Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.


chemosensory behavior

description: Behavior that is dependent upon the sensation of chemicals.


sensory perception of itch

description: A sensory perception which causes the desire or reflex to scratch.


name: small intestine smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.


name: calcitonin gene-related peptide receptor signaling pathway

description: The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers.


response to high light intensity

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.


name: sodium-dependent organic cation transport

description: The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


A secondary ammonium ion that is the conjugate acid of ciprofloxacin resulting from the protonation of the NH group; major species at acidic pH.


An organic iodide salt consisting of pyridinium iodide having a methyl substituent at the 1-position and a 4-dimethylaminostyryl substituent at the 4-position.


autonomic nervous system development

description: The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.


actin filament debranching

description: An actin filament severing process that results in the removal of actin filament branches specifically at the branch points.


thiamine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.


name: positive regulation of peptide hormone secretion

description: Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


name: negative regulation of stress-activated protein kinase signaling cascade

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.


phytoene dehydrogenase activity

description: Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene.


lycopene beta cyclase activity

description: Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively.


15-cis-phytoene synthase activity

description: Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate.


name: LCPS_NEUCR Bifunctional lycopene cyclase/phytoene synthase (sprot)


lycopene

An acyclic carotene commonly obtained from tomatoes and other red fruits.


all-trans-phytofluene

The all-trans-isomer of  phytofluene.


gamma-carotene

A cyclic carotene obtained by the cyclisation of lycopene.


An acyclic carotene having the structure of lycopene with two hydrogen atoms abstracted from the C(3)-C(4) bond to form an extra trans double bond.


Vitamin E

An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.


name: regulation of atrial cardiac muscle cell membrane depolarization

description: Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte.


name: serine/threonine-protein kinase LMTK1 isoform 1 (mouse)

description: A serine/threonine-protein kinase LMTK1 isoform 1 that is encoded in the genome of mouse.


name: regulation of dopaminergic neuron differentiation

description: Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation.


name: regulation of xanthophore differentiation

description: Any process that modulates the frequency, rate or extent of xanthophore differentiation.


osteoclast maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.


regulation of osteoclast development

description: Any process that modulates the frequency, rate or extent of osteoclast development.


name: immune response in brain or nervous system

description: An immune response taking place in the brain or nervous system.


name: positive regulation of macrophage chemotaxis

description: Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


name: positive regulation of neural retina development

description: Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


tacrolimus

A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.


lysobisphosphatidic acid

A lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group.


response to alcohol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.


regulation of phagocytosis

description: Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.


name: cerebellar Golgi cell to granule cell synapse

description: A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.


name: GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human.


name: ACHA_HUMAN Acetylcholine receptor subunit alpha (sprot)

description: An acetylcholine receptor subunit alpha that is encoded in the genome of human.


name: ACHE_HUMAN Acetylcholine receptor subunit epsilon (sprot)

description: An acetylcholine receptor subunit epsilon that is encoded in the genome of human.


name: ACHB_HUMAN Acetylcholine receptor subunit beta (sprot)

description: An acetylcholine receptor subunit beta that is encoded in the genome of human.


name: ACHE_BOVIN Acetylcholine receptor subunit epsilon (sprot)


name: ACHD_HUMAN Acetylcholine receptor subunit delta (sprot)

description: An acetylcholine receptor subunit delta that is encoded in the genome of human.


name: ACHG_BOVIN Acetylcholine receptor subunit gamma (sprot)


name: base-excision repair, AP site formation via deaminated base removal

description: A base-excision repair, AP site formation process occurring via excision of a deaminated base.


name: carcinoembryonic antigen-related cell adhesion molecule 1 sequence variant CEACAM1b (mouse)

description: A carcinoembryonic antigen-related cell adhesion molecule 1 (mouse) that is the protein product of allele b of the CEACAM1 gene in mouse. The sequence has, minimally, a Thr instead of Ile at position 75, and His instead of Arg at position 81 in comparison to allele CEACAM1a (using the sequence numbering of UniProtKB:P31809-1 for the latter).


synaptic vesicle lumen acidification

description: The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.


name: proton-transporting V-type ATPase, V0 domain

description: A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.


STAT family protein binding

description: Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.


name: P-type proton-exporting transporter activity

description: Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.


name: CLCN4_HUMAN H(+)/Cl(-) exchange transporter 4 (sprot)

description: An H(+)/Cl(-) exchange transporter 4 that is encoded in the genome of human.


name: CLCN5_HUMAN H(+)/Cl(-) exchange transporter 5 (sprot)

description: An H(+)/Cl(-) exchange transporter 5 that is encoded in the genome of human.


name: CLCN6_HUMAN H(+)/Cl(-) exchange transporter 6 (sprot)

description: A chloride channel protein 6 that is encoded in the genome of human.


name: positive regulation of stress granule assembly

description: Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


mitotic interphase

description: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.


amyloid-beta clearance

description: The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


name: positive regulation of amyloid-beta clearance

description: Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.


negative regulation of action potential

description: Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


nucleus raphe magnus

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The nucleus raphe magnus, located directly rostral to the raphe obscurus, is afferently stimulated from axons in the spinal cord and cerebellum. This makes the magnus a likely candidate for part of the motor system; however, it seems to participate in the endogenous analgesia system. The magnus receives descending afferents from the periaqueductal gray, the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, parvocellular reticular nucleus and the prelimbic, infralimbic, medial and lateral precentral cortices . All of these brain areas influence the main function of the raphe magnus. The main function of the magnus is mostly pain mediation; in fact it sends projections to the dorsal horn of the spinal cord to directly inhibit pain. The periaquiductal gray, the epicenter of analgesia, sends efferent connections to the nucleus raphe magnus in when it is stimulated by opiates (endogenous or otherwise). Electrical stimulation of the PAG produces analgesia, as well as administration of morphine to the PAG or n.r. magnus. The antinociceptic effects of electrical stimulation of the PAG can be blocked by administering naloxone, an opiate antagonist, to the n.r. magnus. All of this seems to indicate that the magnus is part of the endogenous opiate system, and acts to inhibit pain in the spinal cord. [WP,unvetted].


circadian temperature homeostasis

description: Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.


TNAA_ECOLI Tryptophanase (sprot)

A tryptophanase that is encoded in the genome of Escherichia coli K-12.


surface mucosal cell of stomach

description: A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall.


name: proprotein convertase subtilisin/kexin type 5 isoform PC5A (mouse)

description: A proprotein convertase subtilisin/kexin type 5 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04592-2.


name: EXOC3_HUMAN Exocyst complex component 3 (sprot)

description: An exocyst complex component 3 that is encoded in the genome of human.


name: EXOC6_HUMAN Exocyst complex component 6 (sprot)

description: An exocyst complex component 6 that is encoded in the genome of human.


name: EXOC5_HUMAN Exocyst complex component 5 (sprot)

description: An exocyst complex component 5 that is encoded in the genome of human.


name: EXOC1_HUMAN Exocyst complex component 1 (sprot)

description: An exocyst complex component 1 that is encoded in the genome of human.


name: EXOC2_HUMAN Exocyst complex component 2 (sprot)

description: An exocyst complex component 2 that is encoded in the genome of human.


name: EXOC8_HUMAN Exocyst complex component 8 (sprot)

description: An exocyst complex component 8 that is encoded in the genome of human.


protein maturation by protein folding

description: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein.


name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline

description: The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase.


description: A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.


name: protein localization to secretory granule

description: A process in which a protein is transported to, or maintained in, a location within a secretory granule.


cell trailing edge

description: The area of a motile cell opposite to the direction of movement.


name: anterior visceral endoderm cell migration

description: The orderly movement of an anterior visceral endoderm cell from one site to another.


response to electrical stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.


glial cell growth

description: Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.


renal tubule development

description: The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.


focal adhesion disassembly

description: The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity.


description: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.


name: polarized secretion of basement membrane proteins in epithelium

description: The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium.


tear secretion

description: The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium.


name: maintenance of postsynaptic density structure

description: A process which maintains the organization and the arrangement of proteins in the presynaptic density.


serotonin uptake

description: The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.


response to resveratrol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus.


CAMKK-AMPK signaling cascade

description: The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.


glutamate secretion, neurotransmission

description: The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter.


name: negative regulation of endothelial cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.


regulation of potassium ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


somatostatin secretion

description: The regulated release of somatostatin from secretory granules in the D cells of the pancreas.


regulation of somatostatin secretion

description: Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


name: smooth muscle contraction involved in micturition

description: The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body.


carbohydrate transport

description: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.


peroxisomal importomer complex

description: A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.


name: protein import into peroxisome matrix, translocation

description: The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation.


CCN2_HUMAN CCN family member 2 (sprot)

A CCN family member 2 that is encoded in the genome of human.


name: TBX5_HUMAN T-box transcription factor TBX5 (sprot)

description: A T-box transcription factor TBX5 that is encoded in the genome of human.


name: nuclear receptor subfamily 5 group A member 2 isoform h1 (human)

description: A nuclear receptor subfamily 5 group A member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00482-2.


name: nuclear receptor subfamily 5 group A member 2 isoform h3 (human)

description: A nuclear receptor subfamily 5 group A member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00482-3.


name: nuclear receptor subfamily 1 group I member 2 isoform h1A (human)

description: A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-1.


name: nuclear receptor subfamily 1 group I member 2 isoform h1B (human)

description: A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-2.


name: nuclear receptor subfamily 1 group I member 2 isoform h1C (human)

description: A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-3.


name: nuclear receptor subfamily 1 group I member 2 isoform h2A (human)

description: A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-4.


name: nuclear receptor subfamily 1 group I member 2 isoform h2B (human)

description: A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-5.


name: nuclear receptor subfamily 1 group I member 2 isoform h2C (human)

description: A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-6.


name: nuclear receptor subfamily 1 group I member 2 isoform h3 (human)

description: A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-7.


name: ERR2_HUMAN Steroid hormone receptor ERR2 (sprot)

description: A steroid hormone receptor ERR2 that is encoded in the genome of human.


name: glucocorticoid receptor isoform Alpha (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-1.


name: glucocorticoid receptor isoform Beta (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-2.


name: glucocorticoid receptor isoform hAlpha-2 (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-3.


name: glucocorticoid receptor isoform GR-P (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-4.


name: glucocorticoid receptor isoform GR-A alpha (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-5.


name: glucocorticoid receptor isoform hBeta-2 (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-6.


name: glucocorticoid receptor isoform GR-A beta (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-7.


name: glucocorticoid receptor isoform Alpha-B (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-8.


name: glucocorticoid receptor isoform Beta-B (human)

description: A glucocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04150-9.


progesterone receptor isoform A (human)

A progesterone receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06401-2.


name: mineralocorticoid receptor isoform h1 (human)

description: A mineralocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08235-1.


name: mineralocorticoid receptor isoform h2 (human)

description: A mineralocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08235-2.


name: mineralocorticoid receptor isoform h3 (human)

description: A mineralocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08235-3.


name: mineralocorticoid receptor isoform h4 (human)

description: A mineralocorticoid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08235-4.


name: NR2F6_HUMAN Nuclear receptor subfamily 2 group F member 6 (sprot)

description: A nuclear receptor subfamily 2 group F member 6 that is encoded in the genome of human.


name: COT1_HUMAN COUP transcription factor 1 (sprot)

description: A COUP transcription factor 1 that is encoded in the genome of human.


name: RARB_HUMAN Retinoic acid receptor beta (sprot)

description: A retinoic acid receptor beta that is encoded in the genome of human.


name: THA_HUMAN Thyroid hormone receptor alpha (sprot)

description: A thyroid hormone receptor alpha that is encoded in the genome of human.


name: RARG_HUMAN Retinoic acid receptor gamma (sprot)

description: A retinoic acid receptor gamma that is encoded in the genome of human.


name: RXRB_HUMAN Retinoic acid receptor RXR-beta (sprot)

description: A retinoic acid receptor RXR-beta that is encoded in the genome of human.


name: HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (sprot)

description: A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human.


name: RXRG_HUMAN Retinoic acid receptor RXR-gamma (sprot)

description: A retinoic acid receptor RXR-gamma that is encoded in the genome of human.


name: NR2C2_HUMAN Nuclear receptor subfamily 2 group C member 2 (sprot)

description: A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human.


name: nuclear receptor subfamily 0 group B member 1 isoform 1 (human)

description: A nuclear receptor subfamily 0 group B member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51843-1.


name: nuclear receptor subfamily 0 group B member 1 isoform h2 (human)

description: A nuclear receptor subfamily 0 group B member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51843-2.


name: NR1H2_HUMAN Oxysterols receptor LXR-beta (sprot)

description: An oxysterols receptor LXR-beta that is encoded in the genome of human.


name: ERR3_HUMAN Estrogen-related receptor gamma (sprot)

description: An estrogen-related receptor gamma that is encoded in the genome of human.


name: oxysterols receptor LXR-alpha isoform h1 (human)

description: An oxysterols receptor LXR-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13133-1.


name: oxysterols receptor LXR-alpha isoform h2 (human)

description: An oxysterols receptor LXR-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13133-2.


name: nuclear receptor subfamily 1 group I member 3 isoform h1 (human)

description: A nuclear receptor subfamily 1 group I member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14994-1.


name: nuclear receptor subfamily 1 group I member 3 isoform h2 (human)

description: A nuclear receptor subfamily 1 group I member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14994-2.


name: NR1D2_HUMAN Nuclear receptor subfamily 1 group D member 2 (sprot)

description: A nuclear receptor subfamily 1 group D member 2 that is encoded in the genome of human.


name: nuclear receptor subfamily 6 group A member 1 isoform 1 (human)

description: A nuclear receptor subfamily 6 group A member 1 isoform 1 that is encoded in the genome of human.


name: nuclear receptor subfamily 6 group A member 1 isoform h2 (human)

description: A nuclear receptor subfamily 6 group A member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15406-2.


name: nuclear receptor subfamily 6 group A member 1 isoform h3 (human)

description: A nuclear receptor subfamily 6 group A member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15406-3.


name: nuclear receptor subfamily 6 group A member 1 isoform h4 (human)

description: A nuclear receptor subfamily 6 group A member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15406-4.


name: nuclear receptor subfamily 6 group A member 1 isoform h5 (human)

description: A nuclear receptor subfamily 6 group A member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15406-5.


name: NR0B2_HUMAN Nuclear receptor subfamily 0 group B member 2 (sprot)

description: A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of human.


name: NR2CA_HUMAN Nuclear receptor 2C2-associated protein (sprot)

description: A nuclear receptor 2C2-associated protein that is encoded in the genome of human.


name: nuclear receptor subfamily 4 group A member 3 isoform Alpha (human)

description: A nuclear receptor subfamily 4 group A member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92570-1.


name: nuclear receptor subfamily 4 group A member 3 isoform Beta (human)

description: A nuclear receptor subfamily 4 group A member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92570-2.


name: RORB_HUMAN Nuclear receptor ROR-beta (sprot)

description: A nuclear receptor ROR-beta that is encoded in the genome of human.


name: HDA11_HUMAN Histone deacetylase 11 (sprot)

description: A histone deacetylase 11 that is encoded in the genome of human.


name: nuclear receptor-binding factor 2 isoform h1 (human)

description: A nuclear receptor-binding factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96F24-1.


name: nuclear receptor-binding factor 2 isoform h2 (human)

description: A nuclear receptor-binding factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96F24-2.


bile acid receptor isoform 1 (human)

A bile acid receptor isoform 1 that is encoded in the genome of human.


bile acid receptor isoform h4 (human)

A bile acid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-2.


bile acid receptor isoform h1 (human)

A bile acid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-3.


bile acid receptor isoform h2 (human)

A bile acid receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96RI1-4.


name: NRBP_HUMAN Nuclear receptor-binding protein (sprot)

description: A nuclear receptor-binding protein that is encoded in the genome of human.


name: HDAC9_HUMAN Histone deacetylase 9 (sprot)

description: A histone deacetylase 9 that is encoded in the genome of human.


name: HDAC5_HUMAN Histone deacetylase 5 (sprot)

description: A histone deacetylase 5 that is encoded in the genome of human.


name: NR2E1_HUMAN Nuclear receptor subfamily 2 group E member 1 (sprot)

description: A nuclear receptor subfamily 2 group E member 1 that is encoded in the genome of human.


name: photoreceptor-specific nuclear receptor isoform Long (human)

description: A photoreceptor-specific nuclear receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5X4-1.


name: photoreceptor-specific nuclear receptor isoform Short (human)

description: A photoreceptor-specific nuclear receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y5X4-2.


NuA3 histone acetyltransferase complex

description: A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p.


NuA3a histone acetyltransferase complex

description: A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p.


NuA3b histone acetyltransferase complex

description: A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p.


transcription factor TFIIF complex

description: A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.


name: establishment of protein localization to endoplasmic reticulum membrane

description: The directed movement of a protein to a specific location in the endoplasmic reticulum membrane.


name: AP4M1_HUMAN AP-4 complex subunit mu-1 (sprot)

description: An AP-4 complex subunit mu-1 that is encoded in the genome of human.


saliva secretion

description: The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin.


name: regulation of retrograde trans-synaptic signaling by endocanabinoid

description: Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid.


protein localization to cell periphery

description: A process in which a protein is transported to, or maintained in, the cell periphery.


A monocarboxylic acid anion that is the conjugate base of 3-indoleacrylic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


name: ACDA_CLOS1 3-(aryl)acrylate reductase (sprot)


name: inhibitory G protein-coupled receptor phosphorylation

description: The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site.


name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

description: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript.


name: regulation of response to osmotic stress

description: Any process that modulates the rate or extent of the response to osmotic stress.


ELAV1_HUMAN ELAV-like protein 1 (sprot)

An ELAV-like protein 1 that is encoded in the genome of human.


name: cellular response to carbohydrate stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.


glomerular capillary formation

description: The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


slit diaphragm assembly

description: The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.


name: positive regulation of adenylate cyclase activity

description: Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.


name: regulation of calcium-dependent activation of synaptic vesicle fusion

description: Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion.


name: negative regulation of execution phase of apoptosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.


name: regulation of parathyroid hormone secretion

description: Any process that modulates the frequency, rate or extent of parathyroid hormone secretion.


post-embryonic body morphogenesis

description: The process in which the anatomical structures of the post-embryonic soma are generated and organized.


name: positive regulation of angiotensin-activated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway.


name: NU214_HUMAN Nuclear pore complex protein Nup214 (sprot)

description: A nuclear pore complex protein Nup214 that is encoded in the genome of human.


name: TNF13_HUMAN Tumor necrosis factor ligand superfamily member 13 (sprot)

description: A tumor necrosis factor ligand superfamily member 13 (human), isoforms alpha, beta, gamma, 4, and 5.


name: AN32A_HUMAN Acidic leucine-rich nuclear phosphoprotein 32 family member A (sprot)

description: An acidic leucine-rich nuclear phosphoprotein 32 family member A that is encoded in the genome of human.


name: negative regulation of planar cell polarity pathway involved in axis elongation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.


female genitalia development

description: The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure.


natriuretic peptide receptor activity

description: Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.


c-di-GMP signaling

description: Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal.


name: activation of meiosis involved in egg activation

description: Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation.


cumulus cell differentiation

description: The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell.


vestibulocochlear nerve maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.


response to luteinizing hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.


cellular response to cGMP

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.


response to fibroblast growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus.


response to salt

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.


vascular wound healing

description: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


name: negative regulation of meiotic cell cycle

description: Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.


name: positive regulation of guanylate cyclase activity

description: Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.


name: negative regulation of collateral sprouting

description: Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting.


cGMP-mediated signaling

description: An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell.


name: negative regulation of smooth muscle contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.


An organic anion that is the conjugate base of (S)-warfarin, obtained by deprotonation of the hydroxy group.


sulfide

Any sulfur molecular entity that involves either covalently bonded or anionic sulfur.


name: sarcoplasmic reticulum calcium ion transport

description: The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.


ER-nucleus signaling pathway

description: The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.


name: IZUM4_HUMAN Izumo sperm-egg fusion protein 4 (sprot)

description: An izumo sperm-egg fusion protein 4 that is encoded in the genome of human.


name: IZUM3_HUMAN Izumo sperm-egg fusion protein 3 (sprot)

description: An izumo sperm-egg fusion protein 3 that is encoded in the genome of human.


name: IZUM2_HUMAN Izumo sperm-egg fusion protein 2 (sprot)

description: An izumo sperm-egg fusion protein 2 that is encoded in the genome of human.


name: IZUM1_HUMAN Izumo sperm-egg fusion protein 1 (sprot)

description: An izumo sperm-egg fusion protein 1 that is encoded in the genome of human.


name: regulation of presynaptic dense core granule exocytosis

description: Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.


name: maintenance of presynaptic active zone structure

description: A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters.


name: cellular response to parathyroid hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus.


name: tail-anchored membrane protein insertion into ER membrane

description: A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.


name: SERP1_HUMAN Stress-associated endoplasmic reticulum protein 1 (sprot)

description: A stress-associated endoplasmic reticulum protein 1 that is encoded in the genome of human.


cytochrome b5 isoform 1 (human)

A cytochrome b5 isoform 1 that is encoded in the genome of human.


name: aldehyde dehydrogenase family 3 member A2 isoform h1 (human)

description: An aldehyde dehydrogenase family 3 member A2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51648-1.


name: SC61G_HUMAN Protein transport protein Sec61 subunit gamma (sprot)

description: A protein transport protein Sec61 subunit gamma that is encoded in the genome of human.


OTOF_HUMAN Otoferlin (sprot)

An otoferlin that is encoded in the genome of human.


cellular response to glycoprotein

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.


multicellular organismal locomotion

description: Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another.


response to oxygen-glucose deprivation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose.


description: Catalysis of the reaction: lithocholate + NAD+ = 3-oxo-5beta-cholanate + H+ + NADH.


name: 3AHD_EGGLE 3alpha-hydroxysteroid dehydrogenase (sprot)


name: 3AHDP_MEDG7 3alpha-hydroxysteroid dehydrogenase (sprot)


name: 3BHD2_EGGLE 3beta-hydroxysteroid dehydrogenase 2 (sprot)


name: 3BHDP_MEDG7 3beta-hydroxysteroid dehydrogenase (sprot)


bile acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.


name: G protein-coupled serotonin receptor signaling pathway

description: The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands.


norepinephrine uptake

description: The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.


name: presynaptic dense core vesicle exocytosis

description: The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.


adrenergic receptor activity

description: Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.


tropomyosin binding

description: Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.


name: regulation of nitric oxide mediated signal transduction

description: Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).


name: atrial cardiac muscle tissue morphogenesis

description: The process in which the anatomical structure of cardiac atrium muscle is generated and organized.


Conjugate base of 12alpha-hydroxy-3-oxochola-4,6-dien-24-oic acid.


name: STAR5_HUMAN StAR-related lipid transfer protein 5 (sprot)

description: A StAR-related lipid transfer protein 5 that is encoded in the genome of human.


NR1H4_HUMAN Bile acid receptor (sprot)

A bile acid receptor that is encoded in the genome of human.


name: L-methionine secondary active transmembrane transporter activity

description: Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


name: methionine import across plasma membrane

description: The directed movement of methionine from outside of a cell, across the plasma membrane and into the cytosol.


sulfur amino acid transport

description: The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis

description: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis.


name: negative regulation of actin filament polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.


regulation of microvillus length

description: A process that modulates the length of a microvillus.


acetate metabolic process

description: The chemical reactions and pathways involving acetate, the anion of acetic acid.


host cell PML body

description: A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism.


name: PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (sprot)

description: A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of human.


name: NPC1_HUMAN NPC intracellular cholesterol transporter 1 (sprot)

description: An NPC intracellular cholesterol transporter 1 that is encoded in the genome of human.


response to nutrient levels

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


name: regulation of endothelial cell proliferation

description: Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.


lymphocyte of B lineage

description: A lymphocyte of B lineage with the commitment to express an immunoglobulin complex.


name: transcription preinitiation complex assembly

description: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides.


natural killer cell activation

description: The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.


response to interleukin-12

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


name: lymphocyte activation involved in immune response

description: A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


name: B cell receptor apoptotic signaling pathway

description: An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell.


response to folic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.


response to cisplatin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.


endoplasmic reticulum membrane fusion

description: The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.


name: stress-induced homeostatically regulated protein degradation pathway

description: A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway.


name: SCF complex disassembly in response to cadmium stress

description: The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress.


ARC complex

description: A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.


neuronal action potential propagation

description: The propagation of an action potential along an axon, away from the soma.


name: negative regulation of natural killer cell mediated cytotoxicity

description: Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.


T1 B cell

description: A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative.


name: negative regulation of peptidyl-lysine acetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.


name: acyltransferase activity, acyl groups converted into alkyl on transfer

description: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.


citrate metabolic process

description: The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.


respiratory chain complex II

description: A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.


name: IDH3A_HUMAN Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (sprot)

description: An isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial that is encoded in the genome of human.


succinate-CoA ligase activity

description: Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA.


regulation of catecholamine secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.


name: antisense RNA transcript catabolic process

description: The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product.


name: CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)

description: A CEACAM1a-2S, signal peptide removed form (mouse) that includes at least one N-glycosylasparagine. UniProtKB:P31809-4, 35-278, MOD:00160.


pyruvate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate.


name: lactate biosynthetic process from pyruvate

description: The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate.


lactate oxidation

description: The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons.


lysophosphatidylethanolamine

A glycerophosphoethanolamine resulting from partial hydrolysis of a phosphatidylethanolamine, which removes one of the fatty acid groups. The structure is depicted in the image where R(1) = acyl, R(2) = H or where R(1) = H, R(2) = acyl.


lysophosphatidylethanolamine zwitterion

A zwitterion obtained by transfer of a proton from the phosphate to the amino group of any lysophosphatidylethanolamine. The structure is depicted in the image where R(1) = acyl, R(2) = H or where R(1) = H, R(2) = acyl.


dorsal fin development

description: The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure.


anal fin development

description: The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure.


name: mitochondrial pyruvate transmembrane transport

description: The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion.


description: Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA.


compound eye corneal lens development

description: The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells.


name: NAD(P)H dehydrogenase (quinone) activity

description: Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol.


D-lactate dehydrogenase activity

description: Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate.


name: LDHD_LACDA D-lactate dehydrogenase (sprot)


peptide transport

description: The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: SUCA_HUMAN Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (sprot)

description: A succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial that is encoded in the genome of human.


interleukin-20 binding

description: Binding to interleukin-20.


IL20_MOUSE Interleukin-20 (sprot)

An interleukin-20 that is encoded in the genome of mouse.


name: embryonic olfactory bulb interneuron precursor migration

description: The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb.


regulation of neuron maturation

description: Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.


name: cerebral cortex GABAergic interneuron development

description: The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.


regulation of ERK5 cascade

description: Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


anatomical structure arrangement

description: The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.


GTPase regulator activity

description: Binds to and modulates the activity of a GTPase.


3-hydroxy-L-kynurenine zwitterion

Zwitterionic form of 3-hydroxy-L-kynurenine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3


A hydroxybenzoate that is the conjugate base of 3-hydroxyanthranilic acid.


name: tryptophan catabolic process to kynurenine

description: The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.


name: positive regulation of chronic inflammatory response

description: Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.


kynurenic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid.


regulation of cell projection assembly

description: Any process that modulates the rate, frequency, or extent of cell projection assembly.


name: positive regulation of platelet-derived growth factor receptor-beta signaling pathway

description: Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.


anoikis

description: Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.


lens fiber cell apoptotic process

description: Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


description: Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis.


mycotoxin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus.


name: 'de novo' NAD biosynthetic process from tryptophan

description: The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.


name: pyridoxal phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.


GID complex

description: A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species.


protein glutathionylation

description: The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


synaptonemal complex organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis.


elongator holoenzyme complex

description: A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA.


protein urmylation

description: Covalent attachment of the ubiquitin-like protein URM1 to another protein.


tRNA wobble position uridine thiolation

description: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.


Fc-epsilon receptor I complex

description: A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.


mast cell apoptotic process

description: Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


Kit signaling pathway

description: The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.


stem cell factor receptor binding

description: Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.


serotonin secretion by mast cell

description: The regulated release of serotonin by a mast cell or group of mast cells.


IgE binding

description: Binding to an immunoglobulin of the IgE isotype.


IgE receptor activity

description: Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: outer plaque of mitotic spindle pole body

description: One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm.


astral microtubule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.


name: initial mitotic spindle pole body separation

description: The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB.


establishment of spindle localization

description: The directed movement of the spindle to a specific location in the cell.


name: proteasome core complex, beta-subunit complex

description: The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.