embryonic placenta development

description: The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.


name: mammary gland branching involved in thelarche

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


name: mammary gland branching involved in pregnancy

description: The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy.


name: regulation of vitamin D receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity.


name: positive regulation of G0 to G1 transition

description: A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase.


enucleate erythrocyte development

description: The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


name: positive regulation of protein localization to membrane

description: Any process that activates or increases the frequency, rate or extent of protein localization to membrane.


A hydroxy fatty acid anion that is the conjugate base of 18-hydroxyarachidonic acid, arising from deprotonation of the carboxy group; major species at pH 7.3.


12-hydroxylauric acid

A medium-chain fatty acid that is the 12-hydroxylated derivative of lauric acid.


A HETE that is icosa-5,8,10,14-tetraenoic acid substituted by a hydroxy group at position 12. It is a metabolite of arachidonic acid.


bone marrow development

description: The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.


name: positive regulation of natural killer cell differentiation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.


cellular response to interleukin-12

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


natural killer cell proliferation

description: The expansion of a natural killer cell population by cell division.


bundle of His development

description: The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.


name: positive regulation of astrocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.


enucleate erythrocyte differentiation

description: The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.


entrainment of circadian clock

description: The synchronization of a circadian rhythm to environmental time cues such as light.


ventricular zone

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Proliferative region that is part of the ventricular system.


name: positive regulation of natural killer cell proliferation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.


name: positive regulation of neutrophil differentiation

description: Any process that activates or increases the frequency, rate or extent of neutrophil differentiation.


name: spinal cord oligodendrocyte cell differentiation

description: The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.


pancreatic A cell fate commitment

description: The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


pancreatic PP cell fate commitment

description: The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.


name: spinal cord oligodendrocyte cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.


name: ventral spinal cord interneuron fate determination

description: The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


type B pancreatic cell fate commitment

description: The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.


name: positive regulation of protein serine/threonine phosphatase activity

description: Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity.


AP-1 adaptor complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).


AP-3 adaptor complex

description: A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).


category: biolink:MacromolecularComplex biolink:MacromolecularMachineMixin biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


TTT Hsp90 cochaperone complex

description: A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family.


name: NCK2_MOUSE Cytoplasmic protein NCK2 (sprot)

description: A cytoplasmic protein NCK2 that is encoded in the genome of mouse.


name: EPHB1_MOUSE Ephrin type-B receptor 1 (sprot)

description: An ephrin type-B receptor 1 that is encoded in the genome of mouse.


name: GIT2_MOUSE ARF GTPase-activating protein GIT2 (sprot)

description: An ARF GTPase-activating protein GIT2 that is encoded in the genome of mouse.


transcription elongation factor complex

description: Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.


name: phosphatidylinositol 3-kinase complex, class III

description: A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).


Lsd1/2 complex

description: A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.


name: AF1L1_MOUSE Actin filament-associated protein 1-like 1 (sprot)

description: An actin filament-associated protein 1-like 1 that is encoded in the genome of mouse.


name: PRS8_MOUSE 26S proteasome regulatory subunit 8 (sprot)

description: A 26S proteasome regulatory subunit 8 that is encoded in the genome of mouse.


MIS12/MIND type complex

description: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.


nuclear exosome (RNase complex)

description: A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.


Ndc80 complex

description: An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis.


retromer, cargo-selective complex

description: The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.


TRAMP complex

description: A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control.


mitotic septin complex

description: A heterooligomeric septin complex that acts during mitotic cell division.


name: SPAT2_HUMAN Spermatogenesis-associated protein 2 (sprot)

description: A spermatogenesis-associated protein 2 that is encoded in the genome of human.


name: SNP29_HUMAN Synaptosomal-associated protein 29 (sprot)

description: A synaptosomal-associated protein 29 that is encoded in the genome of human.


name: COG5_HUMAN Conserved oligomeric Golgi complex subunit 5 (sprot)

description: A conserved oligomeric Golgi complex subunit 5 that is encoded in the genome of human.


name: BL1S1_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 1 (sprot)

description: A biogenesis of lysosome-related organelles complex 1 subunit 1 that is encoded in the genome of human.


name: BL1S3_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 3 (sprot)

description: A biogenesis of lysosome-related organelles complex 1 subunit 3 that is encoded in the genome of human.


name: BL1S5_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 5 (sprot)

description: A protein Muted that is encoded in the genome of human.


name: BL1S6_HUMAN Biogenesis of lysosome-related organelles complex 1 subunit 6 (sprot)

description: A biogenesis of lysosome-related organelles complex 1 subunit 6 that is encoded in the genome of human.


myotube differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


name: myotube differentiation involved in skeletal muscle regeneration

description: The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


skeletal muscle fiber adaptation

description: Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


myoblast fate determination

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


name: negative regulation of myoblast proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.


name: positive regulation of transcription by transcription factor localization

description: Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.


name: regulation of adaxial/abaxial pattern formation

description: Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation.


name: chromosome organization involved in meiotic cell cycle

description: A process of chromosome organization that is involved in a meiotic cell cycle.


mitotic DNA-templated DNA replication

description: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle.


replication fork

description: The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.


name: MUS81_HUMAN Crossover junction endonuclease MUS81 (sprot)

description: A crossover junction endonuclease MUS81 that is encoded in the genome of human.


ADP

A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.


primary miRNA processing

description: A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.


glial cell projection

description: A prolongation or process extending from a glial cell.


subapical complex

description: The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.


name: establishment of bipolar cell polarity involved in cell morphogenesis

description: The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane.


regulation of stem cell proliferation

description: Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


pre-miRNA processing

description: A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.


regulation of miRNA metabolic process

description: Any process that modulates the frequency, rate or extent of miRNA metabolic process.


name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity

description: A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.


histone acetyltransferase complex

description: A protein complex that possesses histone acetyltransferase activity.


internal peptidyl-lysine acetylation

description: The addition of an acetyl group to a non-terminal lysine residue in a protein.


protein acetylation

description: The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


protein deacetylation

description: The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


neural tissue regeneration

description: The regrowth of neural tissue following its loss or destruction.


ganglionic eminence

description: The transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles[MP].


cell differentiation in spinal cord

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.


secretory granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.


name: positive regulation of hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.


name: positive regulation of cardiac muscle tissue development

description: Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.


cellular response to hormone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.


cellular response to cAMP

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.


name: regulation of phosphatidylcholine biosynthetic process

description: Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process.


npBAF complex

description: A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.


perichromatin fibrils

description: Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts.


blastocyst hatching

description: The hatching of the cellular blastocyst from the zona pellucida.


heart trabecula formation

description: The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.


embryonic organ morphogenesis

description: Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


name: aortic smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.


name: positive regulation of osteoclast development

description: Any process that activates or increases the frequency, rate or extent of osteoclast development.


name: positive regulation of blood vessel endothelial cell migration

description: Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.


retinal blood vessel morphogenesis

description: The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.


antigen processing and presentation

description: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.


name: CD8-positive, alpha-beta T cell activation

description: The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


name: effector memory CD8-positive, alpha-beta T cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.


name: lymphocyte migration into lymphoid organs

description: The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.


immune system process

description: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.


single-stranded RNA binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to single-stranded RNA.


RNA stabilization

description: Prevention of degradation of RNA molecules.


embryonic neurocranium morphogenesis

description: The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain.


name: proximal/distal pattern formation involved in pronephric nephron development

description: The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros.


name: CD4-positive, CD25-positive, alpha-beta regulatory T cell

description: A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.


tolerance induction to self antigen

description: Tolerance induction directed at self antigens.


name: negative regulation of interleukin-10 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.


name: positive regulation of interleukin-4 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.


name: negative regulation of tumor necrosis factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.


name: negative regulation of isotype switching to IgE isotypes

description: Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.


name: negative regulation of interleukin-6 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.


name: negative regulation of interleukin-5 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.


tolerance induction

description: A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.


name: positive regulation of transforming growth factor beta1 production

description: Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.


positive regulation of T cell anergy

description: Any process that activates or increases the frequency, rate, or extent of T cell anergy.


T cell anergy

description: Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction.


name: negative regulation of interleukin-4 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.


name: regulation of isotype switching to IgG isotypes

description: Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes.


name: positive regulation of peripheral T cell tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.


name: negative regulation of chronic inflammatory response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.


name: positive regulation of regulatory T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.


T cell tolerance induction

description: A process involving any mechanism for tolerance induction in T cells.


name: negative regulation of lymphocyte proliferation

description: Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.


name: positive regulation of T cell tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.


name: positive regulation of immature T cell proliferation in thymus

description: Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus.


name: FOXP3_MOUSE Forkhead box protein P3 (sprot)

description: A forkhead box protein P3 that is encoded in the genome of mouse.


cellular response to interleukin-2

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus.


interleukin-2 receptor binding

description: Binding to an interleukin-2 receptor.


name: regulation of T cell homeostatic proliferation

description: Any process that modulates the frequency, rate or extent of resting T cell proliferation.


name: positive regulation of activated T cell proliferation

description: Any process that activates or increases the rate or extent of activated T cell proliferation.


cellular response to biotic stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.


T cell homeostatic proliferation

description: The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.


C-rich strand telomeric DNA binding

description: Binding to C-rich, single-stranded, telomere-associated DNA.


G-rich strand telomeric DNA binding

description: Binding to G-rich, single-stranded, telomere-associated DNA.


double-stranded telomeric DNA binding

description: Binding to double-stranded telomere-associated DNA.


nucleotidase activity

description: Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.


name: positive regulation of telomere maintenance

description: Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


name: TERF2_HUMAN Telomeric repeat-binding factor 2 (sprot)

description: A telomeric repeat-binding factor 2 that is encoded in the genome of human.


name: meiotic nuclear membrane microtubule tethering complex

description: A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.


name: cytoskeleton-nuclear membrane anchor activity

description: The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane.


name: negative regulation of ribonucleoprotein complex localization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization.


name: cyclin-dependent kinase 2 isoform 1 (mouse)

description: A cyclin-dependent kinase 2 isoform 1 that is encoded in the genome of mouse.


name: regulation of synaptic membrane adhesion

description: Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.


regulation of neuron migration

description: Any process that modulates the frequency, rate or extent of neuron migration.


cerebral cortex marginal layer

description: Developing superficial cortical layer located just under the pia matter, develops from the marginal layer of the neural tube and becomes cortical layer I.


layer of hippocampus

description: The layers of the laminar structure of the hippocampus.


pontine cistern

description: The space located on lateral aspects of the pons at the junction with the celebellum.


hilus of dentate gyrus

description: Layer of the dentate gyrus lying deep to the granule cell layer, within the opening of the C or V formed by the granule cell layer characterized by loosely packed polymorphic cells.


inhibitory interneuron

description: An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS).


name: histone acetyltransferase KAT5 isoform h4 (human)

description: A histone acetyltransferase KAT5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92993-4.


name: LYPL1_HUMAN Lysophospholipase-like protein 1 (sprot)

description: A lysophospholipase-like protein 1 that is encoded in the genome of human.


type I cell of carotid body

description: A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters.


actin filament bundle

description: An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.


perichondral ossification

description: Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage.


actin filament bundle organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


cellular response to retinoic acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.


name: chondrocyte development involved in endochondral bone morphogenesis

description: The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.


collagen type II trimer

description: A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.


pronephros morphogenesis

description: The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.


regulation of neural crest formation

description: Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.


intracellular pH reduction

description: Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.


establishment of vesicle localization

description: The directed movement of a vesicle to a specific location.


enamel mineralization

description: The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.


T-helper 1 cell activation

description: The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


osteoclast proliferation

description: The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.


dentin mineralization

description: The process in which calcium salts are deposited into the calcareous tooth structure known as dentin.


pH reduction

description: Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.


memory T cell activation

description: The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


response to silver ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus.


name: cytoplasm to vacuole targeting by the Cvt pathway

description: A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.


Atg8-family conjugating enzyme activity

description: Isoenergetic transfer of an Atg8 family modifier from one protein to a phosphatidylethanolamine or phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X.


cysteine-type exopeptidase activity

description: Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


Atg12 conjugating enzyme activity

description: Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue.


name: negative regulation of autophagosome assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.


Atg1/ULK1 kinase complex

description: A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.


phagophore assembly site membrane

description: A cellular membrane associated with the phagophore assembly site.


name: cysteine protease ATG4D isoform h2 (human)

description: A cysteine protease ATG4D (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86TL0-2.


name: phosphatidylinositol phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.


otolith mineralization

description: The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear.


lapillus

description: Otolith part of utricle.


otolith morphogenesis

description: The process in which the anatomical structures of an otolith are generated and organized.


egg coat formation

description: Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


detection of gravity

description: The series of events in which a gravitational stimulus is received and converted into a molecular signal.


name: PO2F3_MOUSE POU domain, class 2, transcription factor 3 (sprot)

description: A POU domain, class 2, transcription factor 3 that is encoded in the genome of mouse.


name: VNS1_MOUSE Vomeronasal secretory protein 1 (sprot)

description: A vomeronasal secretory protein 1 that is encoded in the genome of mouse.


SYN2_MOUSE Synapsin-2 (sprot)

A synapsin-2 that is encoded in the genome of mouse.


CRBA2_MOUSE Beta-crystallin A2 (sprot)

A beta-crystallin A2 that is encoded in the genome of mouse.


name: EAA3_MOUSE Excitatory amino acid transporter 3 (sprot)

description: An excitatory amino acid transporter 3 that is encoded in the genome of mouse.


name: G6PD1_MOUSE Glucose-6-phosphate 1-dehydrogenase X (sprot)

description: A glucose-6-phosphate 1-dehydrogenase that is encoded in the genome of mouse.


name: VEGFB_MOUSE Vascular endothelial growth factor B (sprot)

description: A vascular endothelial growth factor B that is encoded in the genome of mouse.


CATE_MOUSE Cathepsin E (sprot)

A cathepsin E that is encoded in the genome of mouse.


name: KLRBC_MOUSE Killer cell lectin-like receptor subfamily B member 1C (sprot)

description: A killer cell lectin-like receptor subfamily B member 1C that is encoded in the genome of mouse.


TPD52_MOUSE Tumor protein D52 (sprot)

A tumor protein D52 that is encoded in the genome of mouse.


CHKA_MOUSE Choline kinase alpha (sprot)

A choline kinase alpha that is encoded in the genome of mouse.


name: BNIP3_MOUSE BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (sprot)

description: A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 that is encoded in the genome of mouse.


name: RDH16_MOUSE Retinol dehydrogenase 16 (sprot)

description: A protein that is a translation product of the Rdh16 gene in mouse.


name: TREX1_MOUSE Three-prime repair exonuclease 1 (sprot)

description: A three-prime repair exonuclease 1 that is encoded in the genome of mouse.


name: DMRT2_MOUSE Doublesex- and mab-3-related transcription factor 2 (sprot)

description: A doublesex- and mab-3-related transcription factor 2 that is encoded in the genome of mouse.


name: B2L10_MOUSE Bcl-2-like protein 10 (sprot)

description: A Bcl-2-like protein 10 that is encoded in the genome of mouse.


name: BNI3L_MOUSE BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (sprot)

description: A BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like that is encoded in the genome of mouse.


RNH1_MOUSE Ribonuclease H1 (sprot)

A ribonuclease H1 that is encoded in the genome of mouse.


name: IKZF2_MOUSE Zinc finger protein Helios (sprot)

description: A zinc finger protein Helios that is encoded in the genome of mouse.


name: HSF4_MOUSE Heat shock factor protein 4 (sprot)

description: A heat shock factor protein 4 that is encoded in the genome of mouse.


name: S27A1_MOUSE Long-chain fatty acid transport protein 1 (sprot)

description: A long-chain fatty acid transport protein 1 that is encoded in the genome of mouse.


name: RNF17_MOUSE RING finger protein 17 (sprot)

description: A RING finger protein 17 that is encoded in the genome of mouse.


name: JMJD6_MOUSE Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (sprot)

description: A bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 that is encoded in the genome of mouse.


name: IRF3_MOUSE Interferon regulatory factor 3 (sprot)

description: An interferon regulatory factor 3 that is encoded in the genome of mouse.


PRDX4_MOUSE Peroxiredoxin-4 (sprot)

A peroxiredoxin-4 that is encoded in the genome of mouse.


NOE1_MOUSE Noelin (sprot)

A noelin that is encoded in the genome of mouse.


name: DCTP1_MOUSE dCTP pyrophosphatase 1 (sprot)

description: A dCTP pyrophosphatase 1 that is encoded in the genome of mouse.


name: KCD20_MOUSE BTB/POZ domain-containing protein KCTD20 (sprot)

description: A BTB/POZ domain-containing protein KCTD20 that is encoded in the genome of mouse.


name: CCD91_MOUSE Coiled-coil domain-containing protein 91 (sprot)

description: A coiled-coil domain-containing protein 91 that is encoded in the genome of mouse.


name: FGOP2_MOUSE FGFR1 oncogene partner 2 homolog (sprot)

description: An FGFR1 oncogene partner 2 that is encoded in the genome of mouse.


S10AG_MOUSE Protein S100-A16 (sprot)

A protein S100-A16 that is encoded in the genome of mouse.


PAAT_MOUSE ATPase PAAT (sprot)

An ATPase PAAT that is encoded in the genome of mouse.


MCLN2_MOUSE Mucolipin-2 (sprot)

A mucolipin-2 that is encoded in the genome of mouse.


PRRC1_MOUSE Protein PRRC1 (sprot)

A protein PPRC1 that is encoded in the genome of mouse.


NUP35_MOUSE Nucleoporin NUP35 (sprot)

A nucleoporin NUP35 that is encoded in the genome of mouse.


name: MISS_MOUSE MAPK-interacting and spindle-stabilizing protein (sprot)

description: A MAPK-interacting and spindle-stabilizing protein that is encoded in the genome of mouse.


name: TRI32_MOUSE E3 ubiquitin-protein ligase TRIM32 (sprot)

description: An E3 ubiquitin-protein ligase TRIM32 that is encoded in the genome of mouse.


name: DMRTD_MOUSE Doublesex- and mab-3-related transcription factor C2 (sprot)

description: A doublesex- and mab-3-related transcription factor C2 that is encoded in the genome of mouse.


CDD_MOUSE Cytidine deaminase (sprot)

A cytidine deaminase that is encoded in the genome of mouse.


name: PACE1_MOUSE Protein-associating with the carboxyl-terminal domain of ezrin (sprot)

description: A protein-associating with the carboxyl-terminal domain of ezrin that is encoded in the genome of mouse.


name: TM38A_MOUSE Trimeric intracellular cation channel type A (sprot)

description: A trimeric intracellular cation channel type A that is encoded in the genome of mouse.


name: CEP72_MOUSE Centrosomal protein of 72 kDa (sprot)

description: A centrosomal protein of 72 kDa that is encoded in the genome of mouse.


name: E2F8_MOUSE Transcription factor E2F8 (sprot)

description: A transcription factor E2F8 that is encoded in the genome of mouse.


name: BACD1_MOUSE BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (sprot)

description: A BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 that is encoded in the genome of mouse.


name: NSMA2_MOUSE Sphingomyelin phosphodiesterase 3 (sprot)

description: A sphingomyelin phosphodiesterase 3 that is encoded in the genome of mouse.


ANO6_MOUSE Anoctamin-6 (sprot)

An anoctamin-6 that is encoded in the genome of mouse.


name: DLK2_MOUSE Protein delta homolog 2 (sprot)

description: A protein delta homolog 2 that is encoded in the genome of mouse.


name: CXG3_MOUSE Gap junction gamma-3 protein (sprot)

description: A gap junction gamma-3 protein that is encoded in the genome of mouse.


name: C209D_MOUSE CD209 antigen-like protein D (sprot)

description: A CD209 molecule-like protein D that is encoded in the genome of mouse.


name: NNRE_MOUSE NAD(P)H-hydrate epimerase (sprot)

description: An apolipoprotein A-I-binding protein that is encoded in the genome of mouse.


CAN8_MOUSE Calpain-8 (sprot)

A calpain-8 that is encoded in the genome of mouse.


name: OLM2B_MOUSE Olfactomedin-like protein 2B (sprot)

description: An olfactomedin-like protein 2B that is encoded in the genome of mouse.


SYT14_MOUSE Synaptotagmin-14 (sprot)

A synaptotagmin-14 that is encoded in the genome of mouse.


name: OLM2A_MOUSE Olfactomedin-like protein 2A (sprot)

description: An olfactomedin-like protein 2A that is encoded in the genome of mouse.


TEN4_MOUSE Teneurin-4 (sprot)

A teneurin-4 that is encoded in the genome of mouse.


name: DMRTA_MOUSE Doublesex- and mab-3-related transcription factor A1 (sprot)

description: A doublesex- and mab-3-related transcription factor A1 that is encoded in the genome of mouse.


name: KLRE1_MOUSE Killer cell lectin-like receptor subfamily E member 1 (sprot)

description: A protein that is a translation product of the Klre1 gene in mouse.


name: PRDM6_MOUSE Putative histone-lysine N-methyltransferase PRDM6 (sprot)

description: A putative histone-lysine N-methyltransferase PRDM6 that is encoded in the genome of mouse.


MYOM3_MOUSE Myomesin-3 (sprot)

A myomesin-3 that is encoded in the genome of mouse.


name: GP139_MOUSE Probable G-protein coupled receptor 139 (sprot)

description: A probable G-protein coupled receptor 139 that is encoded in the genome of mouse.


name: HELT_MOUSE Hairy and enhancer of split-related protein HELT (sprot)

description: A hairy and enhancer of split-related protein HELT that is encoded in the genome of mouse.


name: TLR13_MOUSE Toll-like receptor 13 (sprot)

description: A Toll-like receptor 13 that is encoded in the genome of mouse.


ERFE_MOUSE Erythroferrone (sprot)

An erythroferrone that is encoded in the genome of mouse.


name: ADHX_MOUSE Alcohol dehydrogenase class-3 (sprot)

description: An alcohol dehydrogenase class-3 that is encoded in the genome of mouse.


name: ADH1_MOUSE Alcohol dehydrogenase 1 (sprot)

description: An alcohol dehydrogenase 1 that is encoded in the genome of mouse.


name: PRDX3_MOUSE Thioredoxin-dependent peroxide reductase, mitochondrial (sprot)

description: A thioredoxin-dependent peroxide reductase, mitochondrial that is encoded in the genome of mouse.


name: ASGR1_MOUSE Asialoglycoprotein receptor 1 (sprot)

description: An asialoglycoprotein receptor 1 that is encoded in the genome of mouse.


name: C1QB_MOUSE Complement C1q subcomponent subunit B (sprot)

description: A complement C1q subcomponent subunit B that is encoded in the genome of mouse.


CRBA1_MOUSE Beta-crystallin A1 (sprot)

A beta-crystallin A3 that is encoded in the genome of mouse.


CRBB2_MOUSE Beta-crystallin B2 (sprot)

A beta-crystallin B2 that is encoded in the genome of mouse.


name: BHA15_MOUSE Class A basic helix-loop-helix protein 15 (sprot)

description: A class A basic helix-loop-helix protein 15 that is encoded in the genome of mouse.


name: FKB1A_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP1A (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of mouse.


name: VGFR1_MOUSE Vascular endothelial growth factor receptor 1 (sprot)

description: A vascular endothelial growth factor receptor 1 that is encoded in the genome of mouse.


name: GABP2_MOUSE GA-binding protein subunit beta-2 (sprot)

description: A GA-binding protein subunit beta-2 that is encoded in the genome of mouse.


name: GDF6_MOUSE Growth/differentiation factor 6 (sprot)

description: A growth/differentiation factor 6 that is encoded in the genome of mouse.


name: CXB1_MOUSE Gap junction beta-1 protein (sprot)

description: A gap junction beta-1 protein that is encoded in the genome of mouse.


name: HEXB_MOUSE Beta-hexosaminidase subunit beta (sprot)

description: A beta-hexosaminidase subunit beta that is encoded in the genome of mouse.


GLPA_MOUSE Glycophorin-A (sprot)

A protein that is a translation product of the Gypa gene in mouse.


name: HPRT_MOUSE Hypoxanthine-guanine phosphoribosyltransferase (sprot)

description: A hypoxanthine-guanine phosphoribosyltransferase that is encoded in the genome of mouse.


name: HSF2_MOUSE Heat shock factor protein 2 (sprot)

description: A heat shock factor protein 2 that is encoded in the genome of mouse.


name: IL12B_MOUSE Interleukin-12 subunit beta (sprot)

description: An interleukin-12 subunit beta that is encoded in the genome of mouse.


name: HEM2_MOUSE Delta-aminolevulinic acid dehydratase (sprot)

description: A delta-aminolevulinic acid dehydratase that is encoded in the genome of mouse.


name: ANPRB_MOUSE Atrial natriuretic peptide receptor 2 (sprot)

description: An atrial natriuretic peptide receptor 2 that is encoded in the genome of mouse.


name: PTPRE_MOUSE Receptor-type tyrosine-protein phosphatase epsilon (sprot)

description: A receptor-type tyrosine-protein phosphatase epsilon that is encoded in the genome of mouse.


SYN1_MOUSE Synapsin-1 (sprot)

A synapsin-1 that is encoded in the genome of mouse.


name: TYRP1_MOUSE 5,6-dihydroxyindole-2-carboxylic acid oxidase (sprot)

description: A 5,6-dihydroxyindole-2-carboxylic acid oxidase that is encoded in the genome of mouse.


name: neurotransmitter receptor transport, postsynaptic endosome to lysosome

description: The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.


natural killer cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.


melanosome transport

description: The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cytotoxic T cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.


hemidesmosome

description: A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.


An adenosylhomocysteinase that is encoded in the genome of mouse.


lipid antigen binding

description: Binding to a lipid antigen.


micturition

description: The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.


glucosylceramide metabolic process

description: The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative.


renal system development

description: The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.


cornified envelope assembly

description: The aggregation, arrangement and bonding together of a set of components to form a cornified envelope.


inclusion body assembly

description: The aggregation, arrangement and bonding together of a set of components to form an inclusion body.


prostate gland growth

description: The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.


corneocyte development

description: The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis.


galactosylceramide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.


glycolipid metabolic process

description: The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.


membrane lipid metabolic process

description: The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.


name: cerebellar climbing fiber to Purkinje cell synapse

description: A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata.


locomotory exploration behavior

description: The specific movement from place to place of an organism in response to a novel environment.


regulation of lysosome organization

description: Any process that modulates the frequency, rate or extent of lysosome organization.


manchette

description: A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.


immunological synapse formation

description: The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.


leading edge membrane

description: The portion of the plasma membrane surrounding the leading edge of a motile cell.


uropod

description: A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.


alpha-beta T cell receptor complex

description: A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.


GPI anchor biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.


negative regulation of JNK cascade

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.


apoptotic nuclear changes

description: Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.


name: positive regulation of interleukin-2 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.


MHC class II protein binding

description: Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.


T cell cytokine production

description: Any process that contributes to cytokine production by a T cell.


membrane raft organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


dolichol metabolic process

description: The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.


T cell meandering migration

description: The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs).


name: immune response-inhibiting signal transduction

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.


integrin activation

description: The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.


hydrogen peroxide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


gamma-delta T cell differentiation

description: The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.


mast cell proliferation

description: The expansion of a mast cell population by cell division.


T cell migration

description: The movement of a T cell within or between different tissues and organs of the body.


ninein isoform m1 (mouse)

A ninein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61043-3.


name: negative regulation of T cell mediated cytotoxicity

description: Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.


name: positive regulation of T cell mediated cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.


basophil

description: Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.


mast cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.


cell proliferation in bone marrow

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow.


mast cell cytokine production

description: Any process that contributes to cytokine production by a mast cell.


myeloid dendritic cell chemotaxis

description: The movement of a myeloid dendritic cell in response to an external stimulus.


natural killer cell cytokine production

description: Any process that contributes to cytokine production by a natural killer cell.


exosomal secretion

description: The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.


name: Fc receptor mediated stimulatory signaling pathway

description: The series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.


name: regulation of myeloid leukocyte differentiation

description: Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.


type III interferon production

description: The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far.


name: positive regulation of germinal center formation

description: Any process that activates or increases the frequency, rate, or extent of germinal center formation.


male sex determination

description: The specification of male sex of an individual organism.


description: Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.


description: The chemical reactions and pathways resulting in the formation of androst-4-ene-3,17-dione.


progesterone metabolic process

description: The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.


axonemal microtubule

description: A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.


name: krueppel-like factor 4 unmodified 1 (mouse)

description: A krueppel-like factor 4 (mouse) that lacks modification at the position equivalent to Glu-381 of the amino acid sequence represented by UniProtKB:Q60793. UniProtKB:Q60793, Glu-381, PR:000026291.


fertilization

description: The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).


kidney collecting duct epithelial cell

description: An epithelial cell that is part of the collecting duct of renal tubule.


name: IFT22_HUMAN Intraflagellar transport protein 22 homolog (sprot)

description: An intraflagellar transport protein 22 that is encoded in the genome of human.


name: IFT56_HUMAN Intraflagellar transport protein 56 (sprot)

description: An intraflagellar transport protein 56 that is encoded in the genome of human.


name: IT70B_HUMAN Intraflagellar transport protein 70B (sprot)

description: An intraflagellar transport protein 70B that is encoded in the genome of human.


regulation of blastocyst development

description: Any process that modulates the frequency, rate or extent of blastocyst development.


name: immune response in nasopharyngeal-associated lymphoid tissue

description: An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.


microtubule severing

description: The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends.


positive regulation of cilium movement

description: Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.


name: membrane repolarization during action potential

description: The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


cellular response to copper ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.


name: nucleobase-containing compound metabolic process

description: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.


name: regulation of potassium ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.


nuclear outer membrane

description: The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.


male germ cell nucleus

description: The nucleus of a male germ cell, a reproductive cell in males.


chiasma

description: A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over.


Y chromosome

description: The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.


autosome

description: Any chromosome other than a sex chromosome.


transverse filament

description: A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.


outer kinetochore

description: The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.


P granule

description: A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.


perinuclear endoplasmic reticulum

description: The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.


centriole replication

description: The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.


name: meiotic attachment of telomere to nuclear envelope

description: The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation.


meiotic telomere clustering

description: The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis.


axonemal dynein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


name: resolution of meiotic recombination intermediates

description: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.


male meiotic nuclear division

description: A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.


male meiosis chromosome segregation

description: The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male.


sperm DNA condensation

description: The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication.


lateral element assembly

description: The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements.


name: meiotic sister chromatid cohesion involved in meiosis I

description: The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I.


meiotic cell cycle phase transition

description: The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase.


name: germline cell cycle switching, mitotic to meiotic cell cycle

description: The process in which a germline cell switches cell cycle mode from mitotic to meiotic division.


name: chromosome localization to nuclear envelope involved in homologous chromosome segregation

description: The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.


synaptonemal complex disassembly

description: The controlled breakdown of a synaptonemal complex.


trachea development

description: The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.


tube development

description: The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.


vesicle membrane

description: The lipid bilayer surrounding any membrane-bounded vesicle in the cell.


chromatoid body

description: A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).


pi-body

description: A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes.


sperm head-tail coupling apparatus

description: A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head.


manchette assembly

description: The aggregation, arrangement and bonding together of a set of components to form a manchette.


intramanchette transport

description: The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments.


spermatid nucleus elongation

description: The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation.


sperm individualization

description: The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.


phosphatidylcholine metabolic process

description: The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.


equatorin isoform 2 (mouse)

An equatorin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9D9V2-2.


name: negative regulation of endothelial cell proliferation

description: Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.


name: negative regulation of nitric oxide mediated signal transduction

description: Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO).


name: positive regulation of cell-substrate adhesion

description: Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.


name: negative regulation of endothelial cell chemotaxis

description: Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.


extracellular exosome

description: A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.


opsonin binding

description: Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.


microglia development

description: The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


leukocyte cell-cell adhesion

description: The attachment of a leukocyte to another cell via adhesion molecules.


name: positive regulation of Rho protein signal transduction

description: Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.


name: positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly

description: Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.


name: positive regulation of actin filament bundle assembly

description: Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.


name: regulation of complement activation, classical pathway

description: Any process that modulates the frequency, rate or extent of the classical pathway of complement activation.


interferon-alpha production

description: The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: positive regulation of interferon-alpha production

description: Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.


name: G3P_PIG Glyceraldehyde-3-phosphate dehydrogenase (sprot)


manganese ion transmembrane transport

description: A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


zinc ion transport

description: The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


pronephros structural organization

description: The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.


oviduct epithelium development

description: The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct.


name: positive regulation of type IIa hypersensitivity

description: Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.


complement-dependent cytotoxicity

description: Cell killing caused by the membrane attack complex formed following complement activation.


name: glomerular basement membrane development

description: The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.


negative regulation of immune response

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.


NFAT protein

A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833).


NFAT activation molecule 1

A protein that is a translation product of the human NFAM1 gene or a 1:1 ortholog thereof.


artery smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart.


name: S22A8_HUMAN Organic anion transporter 3 (sprot)

description: An organic anion transporter 3 that is encoded in the genome of human.


name: negative regulation of complement activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.


olfactory bulb axon guidance

description: The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues.


anterior commissure morphogenesis

description: Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.


ventral aorta development

description: The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.


complement receptor activity

description: Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: positive regulation of cartilage development

description: Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


regulation of cell-cell adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.


name: positive regulation of alpha-beta T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.


name: positive regulation of calcium-mediated signaling

description: Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.


homotypic cell-cell adhesion

description: The attachment of a cell to a second cell of the identical type via adhesion molecules.


name: positive regulation of cell adhesion mediated by integrin

description: Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.


name: negative regulation of erythrocyte clearance

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance.


name: positive regulation of inflammatory response to antigenic stimulus

description: Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.


name: negative regulation of T cell homeostatic proliferation

description: Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.


name: positive regulation of integrin activation

description: Any process that activates or increases the frequency, rate, or extent of integrin activation.


name: positive regulation of cell-cell adhesion mediated by integrin

description: Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin.


name: positive regulation of T cell homeostatic proliferation

description: Any process that activates or increases the rate or extent of resting T cell proliferation.


name: positive regulation of T cell mediated immune response to tumor cell

description: Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell.


name: regulation of cell-cell adhesion mediated by integrin

description: Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin.


name: negative regulation of erythrocyte aggregation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation.


endothelial cell-matrix adhesion

description: The binding of an endothelial cell to the extracellular matrix via adhesion molecules.


negative regulation of coagulation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.


name: negative regulation of activation of membrane attack complex

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.


response to protozoan

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.


negative thymic T cell selection

description: The process of elimination of immature T cells in the thymus which react strongly with self-antigens.


regulation of defense response to virus

description: Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.


name: negative regulation of type IV hypersensitivity

description: Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.


cardiac septum development

description: The progression of a cardiac septum over time, from its initial formation to the mature structure.


hyaluronic acid binding

description: Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.


name: D-glucuronate transmembrane transporter activity

description: Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other.


endosome to lysosome transport

description: The directed movement of substances from endosomes to lysosomes.


name: branching involved in prostate gland morphogenesis

description: The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.


name: wound healing involved in inflammatory response

description: The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.


calmodulin

A protein that is a translation product of the human CALM1, CALM2, or CALM3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.


septin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins.


regulation of p38MAPK cascade

description: Any process that modulates the frequency, rate or extent of p38MAPK cascade.


name: positive regulation of protein autophosphorylation

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.


epidermis development

description: The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.


hindgut development

description: The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.


cerebellar cortex morphogenesis

description: The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


mammary gland duct morphogenesis

description: The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk.


name: spinal cord ventral commissure morphogenesis

description: The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized.


ventral midline development

description: The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.


hindgut morphogenesis

description: The process in which the anatomical structures of the hindgut are generated and organized.


ventral spinal cord development

description: The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.


sphingolipid mediated signaling pathway

description: The series of molecular signals mediated by a sphingolipid.


name: cell migration to the midline involved in heart development

description: The orderly movement of a cell toward the midline that contributes to the progression of the heart over time.


cellular response to ceramide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus.


vesicle budding from membrane

description: The evagination of a membrane, resulting in formation of a vesicle.


name: mRNA localization resulting in post-transcriptional regulation of gene expression

description: Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintenance in, a specific location within the cell.


name: long-chain fatty acid import across plasma membrane

description: The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


vitamin A import into cell

description: The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid.


neurohypophysis development

description: The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.


locus ceruleus development

description: The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.


vestibular receptor cell development

description: The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.


name: positive regulation of developmental pigmentation

description: Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.


corpus callosum development

description: The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.


name: detection of hot stimulus involved in thermoception

description: The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception.


WD40-repeat domain binding

description: Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain.


name: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands

description: Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand.


actin cortical patch assembly

description: Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.


maintenance of mitochondrion location

description: Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere.


retrograde dendritic transport

description: The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body.


hypothalamus

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia].


sensory perception of smell

description: The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.


inferior olivary nucleus

description: The inferior olivary nucleus is the largest nucleus situated in the olivary body, part of the medulla oblongata.