terminal web

description: An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.


terminal web assembly

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The aggregation, arrangement and bonding together of a set of components to form a terminal web.


epithelial cell apoptotic process

description: Any apoptotic process in an epithelial cell.


name: aryl hydrocarbon receptor nuclear translocator

description: A protein that is a translation product of the human ARNT gene or a 1:1 ortholog thereof.


hypoxia-inducible factor 1-alpha

A protein that is a translation product of the human HIF1A gene or a 1:1 ortholog thereof.


exon-exon junction complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.


name: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

description: Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay.


name: regulation of eye photoreceptor cell development

description: Any process that modulates the frequency, rate or extent of eye photoreceptor development.


neuron cell-cell adhesion

description: The attachment of a neuron to another cell via adhesion molecules.


pigment cell development

description: The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.


hindbrain structural organization

description: The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.


name: cell-cell adhesion via plasma-membrane adhesion molecules

description: The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane.


dorsal fin morphogenesis

description: The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins.


name: cell migration involved in somitogenic axis elongation

description: Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation.


axial mesoderm structural organization

description: The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure.


STRN_HUMAN Striatin (sprot)

A striatin that is encoded in the genome of human.


CAV2_HUMAN Caveolin-2 (sprot)

A caveolin-2 that is encoded in the genome of human.


name: negative regulation of phosphate transmembrane transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport.


cell junction maintenance

description: The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.


tight junction

description: A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


CLD3_HUMAN Claudin-3 (sprot)

A claudin-3 that is encoded in the genome of human.


name: microtubule cytoskeleton organization involved in mitosis

description: Any microtubule cytoskeleton organization that is involved in mitosis.


LITHIUM

An alkali metal hydride where the metal is specified as lithium.


chloroacetaldehyde

Acetaldehyde substituted at C-2 by chlorine.


sodium chlorate

An inorganic sodium salt that has chlorate as the counter-ion. An oxidising agent, it is used for bleaching paper and as a herbicide. It is also used in the manufacture of dyes, explosives and matches.


biotin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.


6-carboxyhexanoate-CoA ligase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H+ + pimelyl-CoA.


description: Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA.


name: NVFJ_ASPN1 Asnovolin E/Chermesin D methyltransferase nvfJ (sprot)


name: inward rectifier potassium channel 13 isoform m2 (mouse)

description: An inward rectifier potassium channel 13 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P86046-1 except that amino acids 155-360 have been replaced by the sequence KRKW. UniProtKB:P86046-1, 1-154, KRKW.


name: negative regulation of potassium ion transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)

description: A voltage-gated potassium channel subunit KCNA5 isoform 3 that is encoded in the genome of mouse.


tyrosine transport

description: The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


arginine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


regulation of filopodium assembly

description: Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


terminal Schwann cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse.


melibiose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose.


maltose alpha-glucosidase activity

description: Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose.


maltose transmembrane transport

description: The process in which maltose is transported across a membrane.


description: The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


description: The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


description: The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


mitochondrial lysyl-tRNA aminoacylation

description: The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


description: The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


description: The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


name: ELF3_HUMAN ETS-related transcription factor Elf-3 (sprot)

description: An ETS-related transcription factor Elf-3 that is encoded in the genome of human.


name: mitochondrial respiratory chain complex III

description: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.


name: trehalose transmembrane transporter activity

description: Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens.


name: maltose:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in).


disaccharide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units.


maltose transport

description: The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch.


negative regulation of transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate

description: The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate.


notochord cell vacuolation

description: The assembly and arrangement of a vacuole within a cell of the notochord.


regulation of cilium assembly

description: Any process that modulates the frequency, rate or extent of cilium assembly.


regulation of heart looping

description: Any process that modulates the frequency, rate or extent of heart looping.


eye pigment granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.


protein adenylylation

description: The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid.


A carbon oxoanion that results from the removal of a proton from nitrosoperoxycarbonic acid. It is formed in vivo by nucleophilic reaction of peroxynitrite with carbon dioxide, and is an important reactive species in inflammation processes.


hydroperoxy fatty acid anion

A fatty acid anion that is the conjugate base of any hydroperoxy fatty acid, formed by deprotonation of the carboxylic acid moiety.


cortisol metabolic process

description: The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


GCN2-mediated signaling

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation.


tRNA 3'-end processing

description: The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.


tRNA 3'-terminal CCA addition

description: Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition.


name: symbiont-mediated suppression of host defense-related programmed cell death

description: Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: symbiont-mediated suppression of host inflammatory response

description: A process in which a symbiont inhibits or disrupts the normal execution of  inflammatory response in the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

description: Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.


name: intracellularly cAMP-activated cation channel activity

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.


name: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.


name: general adaptation syndrome, behavioral process

description: The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus.


reproductive process

description: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.


name: amyloid precursor protein metabolic process

description: The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.


reproductive structure development

description: The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.


name: behavioral response to formalin induced pain

description: Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus.


name: positive regulation of long-term synaptic potentiation

description: Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.


efferent neuron

description: A neuron which sends impulses peripherally to activate muscles or secretory cells.


peripheral nervous system

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.


name: F6M3L0_LAMFL EH-domain containing protein (trembl)


name: F6VEL3_MACMU Calcyon neuron specific vesicular protein (trembl)


name: A0A452E1P4_CAPHI Guanine nucleotide-binding protein G(i) subunit alpha-2 (trembl)


name: F1NTC8_CHICK PDZ and LIM domain 5 (trembl)


name: peripheral nervous system neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system.


ganglion development

description: The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.


temperature-gated ion channel activity

description: Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).


collection of basal ganglia

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum.


name: LIN7B_MOUSE Protein lin-7 homolog B (sprot)

description: A protein lin-7 homolog B that is encoded in the genome of mouse.


name: positive regulation of epithelial cell proliferation involved in lung morphogenesis

description: Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.


growth

description: The increase in size or mass of an entire organism, a part of an organism or a cell.


vocal learning

description: A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.


regulation of dendrite development

description: Any process that modulates the frequency, rate or extent of dendrite development.


name: H9FSF4_MACMU Gamma-aminobutyric acid type B receptor subunit 1 isoform a (trembl)


name: voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

description: Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.


regulation of vasoconstriction

description: Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.


name: negative regulation of intracellular signal transduction

description: Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.


name: regulation of intracellular signal transduction

description: Any process that modulates the frequency, rate or extent of intracellular signal transduction.


14-3-3 protein binding

description: Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.


name: regulation of insulin receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of insulin receptor signaling.


name: positive regulation of insulin receptor signaling pathway

description: Any process that increases the frequency, rate or extent of insulin receptor signaling.


dendrite membrane

description: The portion of the plasma membrane surrounding a dendrite.


neuronal cell body membrane

description: The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.


cell-cell signaling via exosome

description: Cell-cell signaling in which the ligand is carried between cells by an exosome.


name: F6XUP1_MACMU non-specific serine/threonine protein kinase (trembl)


name: F7BYT9_MACMU Rho guanine nucleotide exchange factor 2 (trembl)


name: A0A1D5QJ26_MACMU Regulator of G protein signaling 12 (trembl)


name: A0A5K1VKW3_MACMU Regulator of G protein signaling 14 (trembl)


name: A0A4D6IX63_HUMAN RPS23 retroposed 1 (trembl)


SYT17_HUMAN Synaptotagmin-17 (sprot)

A synaptotagmin-17 that is encoded in the genome of human.


name: regulation of postsynaptic cytosolic calcium ion concentration

description: Any process that regulates the concentration of calcium in the postsynaptic cytosol.


name: negative regulation of intracellular transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.


name: regulation of cell-cell adhesion mediated by cadherin

description: Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin.


name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.


anterior neural plate formation

description: The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate.


regulation of leukocyte migration

description: Any process that modulates the frequency, rate, or extent of leukocyte migration.


neutrophil mediated immunity

description: Any process involved in the carrying out of an immune response by a neutrophil.


name: regulation of establishment or maintenance of cell polarity

description: Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


nuclear migration along microtubule

description: The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.


negative regulation of proteolysis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


name: negative regulation of mitotic recombination

description: Any process that inhibits or decreases the rate of DNA recombination during mitosis.


name: regulation of mesenchymal stem cell differentiation

description: Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation.


nuclear replisome

description: A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


DNA helicase A complex

description: A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction.


postreplication repair

description: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.


organelle membrane

description: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.


optokinetic behavior

description: The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.


cellular response to anoxia

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.


lamellar body membrane

description: The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.


APOB_HUMAN Apolipoprotein B-100 (sprot)

An apolipoprotein B-100 that is encoded in the genome of human.


name: ABCA3_HUMAN Phospholipid-transporting ATPase ABCA3 (sprot)

description: A phospholipid-transporting ATPase ABCA3 that is encoded in the genome of human.


name: regulation of T-helper 2 cell cytokine production

description: Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production.


name: regulation of intestinal epithelial cell development

description: Any process that modulates the frequency, rate or extent of intestinal epithelial cell development.


branching morphogenesis of a nerve

description: The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).


melanocyte migration

description: The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.


name: pigment granule aggregation in cell center

description: The directed movement of dispersed pigment granules towards the center of the cell.


pigment granule dispersal

description: The directed movement of pigment granules within a cell towards the cell periphery.


pyridoxal phosphate binding

description: Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.


alanine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid.


alanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid.


name: L-alanine catabolic process, by transamination

description: The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination.


name: L-alanine biosynthetic process from pyruvate

description: The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate.


name: positive regulation of iridophore differentiation

description: Any process that activates or increases the frequency, rate or extent of iridophore differentiation.


translation elongation factor binding

description: Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.


transcription preinitiation complex

description: A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.


transcription factor TFIIH holo complex

description: A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.


transcription factor TFIIH core complex

description: The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.


name: nucleotide-excision repair factor 3 complex

description: One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).


name: transcription open complex formation at RNA polymerase II promoter

description: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.


RNA polymerase II promoter clearance

description: A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.


arachidonic acid monooxygenase activity

description: Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water.


regulation of DNA replication

description: Any process that modulates the frequency, rate or extent of DNA replication.


name: negative regulation of sister chromatid cohesion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion.


name: negative regulation of chromosome segregation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.


ceramide translocation

description: The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet.


glycosylceramide

A ceramide compound formed by the replacement of the glycosidic hydroxy group of a cyclic form of a monosaccharide (or derivative) by a ceramide group.


aminophospholipid flippase activity

description: Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group.


description: A protein complex that functions as a phospholipid-translocating P-Type ATPase.


name: TIM22 mitochondrial import inner membrane insertion complex

description: A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.


nuclear pore organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore.


spliceosomal complex disassembly

description: Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.


name: NCBP1_HUMAN Nuclear cap-binding protein subunit 1 (sprot)

description: A nuclear cap-binding protein subunit 1 that is encoded in the genome of human.


name: NCBP2_HUMAN Nuclear cap-binding protein subunit 2 (sprot)

description: A nuclear cap-binding protein subunit 2 that is encoded in the genome of human.


name: SRSF9_HUMAN Serine/arginine-rich splicing factor 9 (sprot)

description: A serine/arginine-rich splicing factor 9 that is encoded in the genome of human.


name: SRSF5_HUMAN Serine/arginine-rich splicing factor 5 (sprot)

description: A serine/arginine-rich splicing factor 5 that is encoded in the genome of human.


name: SRS11_HUMAN Serine/arginine-rich splicing factor 11 (sprot)

description: A serine/arginine-rich splicing factor 11 that is encoded in the genome of human.


name: U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (sprot)

description: A splicing factor U2AF 65 kDa subunit that is encoded in the genome of human.


name: SRSF4_HUMAN Serine/arginine-rich splicing factor 4 (sprot)

description: A serine/arginine-rich splicing factor 4 that is encoded in the genome of human.


name: U2AF1_HUMAN Splicing factor U2AF 35 kDa subunit (sprot)

description: A splicing factor U2AF 35 kDa subunit that is encoded in the genome of human.


name: U2AF4_HUMAN Splicing factor U2AF 26 kDa subunit (sprot)

description: A splicing factor U2AF 26 kDa subunit that is encoded in the genome of human.


pancreatic D cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.


enteroendocrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.


pancreatic epsilon cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin.


name: negative regulation of pancreatic A cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation.


name: establishment of protein-containing complex localization to telomere

description: The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.


neuroblast differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.


cell division site

description: The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.


cellular bud neck septin collar

description: A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck.


cellular bud neck split septin rings

description: Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated.


axial cellular bud site selection

description: The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell.


name: protein localization to cell division site after cytokinesis

description: A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis.


name: negative regulation of amyloid fibril formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.


maintenance of nucleus location

description: Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere.


name: negative regulation of satellite cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation.


name: SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (sprot)

description: An NAD-dependent deacetylase sirtuin-5 that is encoded in the genome of human.


A glycerophosphocholine having an unspecified O-acyl substituent at the 1-position of the glycerol fragment.


lysophosphatidylcholine 14:0

A lysophosphatidylcholine in which the remaining acyl group is specified as tetradecanoyl (myristoyl). If R1 is the acyl group and R2 is a hydrogen then the molecule is a 1-acyl-sn-glycero-3-phosphocholine.  If R1 is a hydrogen and R2 is the acyl group then the molecule is a 2-acyl-sn-glycero-3-phosphocholine.


lysophosphatidylcholine 22:6

An acyl-sn-glycero-3-phosphocholine in which the acyl group (position not specified) contains 22 carbons with 6 double bonds.


name: PPCT_HUMAN Phosphatidylcholine transfer protein (sprot)

description: A phosphatidylcholine transfer protein that is encoded in the genome of human.


name: STAR7_HUMAN StAR-related lipid transfer protein 7, mitochondrial (sprot)

description: A StAR-related lipid transfer protein 7, mitochondrial that is encoded in the genome of human.


histone H3-containing nucleosome

description: A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures.


MSL complex

description: A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.


name: X chromosome located dosage compensation complex, transcription activating

description: An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster.


An alkyl,acyl-sn-glycero-3-phosphocholine in which unspecified alkyl and acyl groups are located at positions 1 and 2 respectively.


alkylglycerol

A glycerol ether having at least one alkyl substituent on oxygen.


name: histone acetyltransferase regulator activity

description: Binds to and modulates the activity of histone acetyltransferase.


name: intracellular distribution of mitochondria

description: Any process that establishes the spatial arrangement of mitochondria within the cell.


name: positive regulation of protein deacetylation

description: Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


name: cellular tumor antigen p53 acetylated 2 (mouse)

description: A cellular tumor antigen p53 (mouse) that has been acetylated at the position equivalent to Lys-379 of the amino acid sequence represented by UniProtKB:P02340. UniProtKB:P02340, Lys-379, MOD:00064.


intra-Golgi vesicle-mediated transport

description: The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).


COPI vesicle coat

description: One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.


name: regulation of snRNA pseudouridine synthesis

description: Any process that modulates the frequency, rate or extent of snRNA pseudouridine synthesis.


mitochondria-nucleus signaling pathway

description: The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function.


regulation of axon regeneration

description: Any process that modulates the frequency, rate or extent of axon regeneration.


epidermal growth factor binding

description: Binding to epidermal growth factor.


morphogenesis of an epithelial fold

description: The morphogenetic process in which an epithelial sheet bends along a linear axis.


neuregulin binding

description: Binding to a neuregulin, a member of the EGF family of growth factors.


name: establishment of planar polarity involved in nephron morphogenesis

description: Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron.


name: gamma-aminobutyric acid receptor subunit alpha-1

description: A GABA(A) receptor protein that is a translation product of the human GABRA1 gene or a 1:1 ortholog thereof.


name: gamma-aminobutyric acid receptor subunit alpha-6

description: A GABA(A) receptor protein that is a translation product of the human GABRA6 gene or a 1:1 ortholog thereof.


name: gamma-aminobutyric acid receptor subunit alpha-5

description: A GABA(A) receptor protein that is a translation product of the human GABRA5 gene or a 1:1 ortholog thereof.


name: regulation of gamma-delta T cell differentiation

description: Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.


positive regulation of timing of anagen

description: Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle.


nail development

description: The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.


epidermal-dermal junction

description: The multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction.


glycosphingolipid binding

description: Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.


tongue morphogenesis

description: The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.


mammary gland epithelium development

description: The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


outflow tract septum morphogenesis

description: The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.


name: wound healing, spreading of epidermal cells

description: The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.


name: negative regulation of transcription regulatory region DNA binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.


frontal suture morphogenesis

description: The process in which the frontal suture is generated and organized.


name: positive regulation of timing of catagen

description: Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


cellular response to estradiol stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.


name: negative regulation of CREB transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.


activation of meiosis

description: Any process that starts the inactive process of meiosis.


hair inner root sheath

description: A multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle[MP].


hair cycle

description: The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.


regulation of hair cycle

description: Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.


name: positive regulation of chondrocyte proliferation

description: Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.


trachea gland development

description: The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection.


name: regulation of metalloendopeptidase activity

description: Any process that modulates the frequency, rate or extent of metalloendopeptidase activity.


name: negative regulation of cardiac muscle cell apoptotic process

description: Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.


coronary vasculature morphogenesis

description: The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.


tricuspid valve formation

description: The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


name: cardiac vascular smooth muscle cell development

description: The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state.


positive regulation of binding

description: Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.


membrane biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.


keratin filament binding

description: Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.


name: regulation of antibacterial peptide production

description: Any process that modulates the frequency, rate, or extent of antibacterial peptide production.


mitochondrial DNA replication

description: The process in which new strands of DNA are synthesized in the mitochondrion.


name: positive regulation of G1/S transition of mitotic cell cycle

description: Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


name: regulation of succinate dehydrogenase activity

description: Any process that modulates the frequency, rate or extent of succinate dehydrogenase activity.


name: cell differentiation involved in embryonic placenta development

description: The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta.


peptide secretion

description: The controlled release of a peptide from a cell or a tissue.


name: regulation of integrin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.


spot adherens junction

description: A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens.


name: KAD2_HUMAN Adenylate kinase 2, mitochondrial (sprot)

description: An adenylate kinase 2, mitochondrial that is encoded in the genome of human.


description: The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol.


regulation of type 2 immune response

description: Any process that modulates the frequency, rate, or extent of a type 2 immune response.


regulation of T cell migration

description: Any process that modulates the frequency, rate or extent of T cell migration.


name: alcohol-forming very long-chain fatty acyl-CoA reductase activity

description: Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


name: post-embryonic camera-type eye development

description: The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure.


Golgi cis cisterna

description: The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.


name: neutral sphingomyelin phosphodiesterase activity

description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment.


peptide hormone secretion

description: The regulated release of a peptide hormone from a cell.


dentinogenesis

description: The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin.


sphingomyelin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.


polysaccharide transport

description: The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


name: negative regulation of hyaluronan biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.


cellular response to magnesium ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.


sphingomyelin metabolic process

description: The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine.


long-chain fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


diacylglycerol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


name: negative regulation of amyloid-beta clearance

description: Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance.


clathrin-sculpted vesicle

description: A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release.


multivesicular body, internal vesicle

description: A membrane-bounded vesicle wholly contained within a multivesicular body.


contractile ring

description: A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles.


kidney arterial blood vessel cell

description: Any kidney blood vessel cell that is part of some kidney arterial blood vessel.


motile cell

description: A cell that moves by its own activities.


endosome to melanosome transport

description: The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.


L-histidine metabolic process

description: The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.


lysine metabolic process

description: The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.


name: regulation of plasma lipoprotein particle levels

description: Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism.


actin filament network formation

description: The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.


aspartate metabolic process

description: The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.


bradykinin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin.


name: VP33B_HUMAN Vacuolar protein sorting-associated protein 33B (sprot)

description: A vacuolar protein sorting-associated protein 33B that is encoded in the genome of human.


name: L-glutamine transmembrane transporter activity

description: Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid.


glutamine transport

description: The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


microfibril

description: Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.


capsule of lens

description: The elastic, clear, membrane-like structure, that is outer most layer of the lens.


muscle cell projection membrane

description: The portion of the plasma membrane surrounding a muscle cell projection.


name: positive regulation of substrate adhesion-dependent cell spreading

description: Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.


sarcoplasm

description: The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.


microfibril binding

description: Binding to a microfibril, any small fibril occurring in biological material.


name: extracellular matrix constituent conferring elasticity

description: A component of the extracellular matrix that enables the matrix to recoil after transient stretching.


supramolecular fiber organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.


hippocampal mossy fiber

description: An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal.


positive regulation of transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


AP-1 adaptor complex binding

description: Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).


name: positive regulation of cholesterol import

description: Any process that activates or increases the frequency, rate or extent of cholesterol import.


name: Arp2/3 complex-mediated actin nucleation

description: The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.


lytic vacuole

description: A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.


name: positive regulation of protein exit from endoplasmic reticulum

description: Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum.


macrophage proliferation

description: The expansion of a macrophage population by cell division.


septin cytoskeleton

description: The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes.


pseudopodium retraction

description: The myosin-based contraction and retraction of a pseudopodium.


cortical cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


cellular pigmentation

description: The deposition or aggregation of coloring matter in a cell.


name: CD8-positive, alpha-beta T cell differentiation involved in immune response

description: The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.


name: unconventional myosin-IXb isoform 3 (mouse)

description: An unconventional myosin-IXb (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QY06-3.


name: unconventional myosin-IXb isoform 1 (mouse)

description: An unconventional myosin-IXb (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QY06-1.


ATPase binding

description: Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.


name: negative regulation of ryanodine-sensitive calcium-release channel activity

description: Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


name: negative regulation of protein localization to cilium

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.


lysosomal matrix

description: A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome.


name: chaperone cofactor-dependent protein refolding

description: The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.


clathrin coat disassembly

description: The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system.


collagen receptor activity

description: Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: positive regulation of B cell activation

description: Any process that activates or increases the frequency, rate or extent of B cell activation.


name: TRPDC_MEDG7 Tryptophan decarboxylase (sprot)


name: TRPC_BACTN Indole-3-glycerol phosphate synthase (sprot)


name: TRPDC_CLOS1 Tryptophan decarboxylase (sprot)


granuloma formation

description: The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.


acetoacetic acid metabolic process

description: The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH.


FBN2_MOUSE Fibrillin-2 (sprot)

A fibrillin-2 that is encoded in the genome of mouse.


name: S35D3_HUMAN Solute carrier family 35 member D3 (sprot)

description: A solute carrier family 35 member D3 that is encoded in the genome of human.


microtubule-based process

description: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.


name: mast cell secretory granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.


zinc export across plasma membrane

description: The directed movement of zinc ions from a cell, into the extracellular region.


dopachrome isomerase activity

description: Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.


name: regulation of establishment of blood-brain barrier

description: Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.


name: synaptic vesicle fusion to presynaptic active zone membrane

description: Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.


terminal button organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.


name: regulation of phosphoprotein phosphatase activity

description: Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.


actin rod assembly

description: The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.


glomerular mesangial cell development

description: The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure.


name: regulation of protein targeting to vacuolar membrane

description: Any process that modulates the frequency, rate or extent of protein targeting to vacuolar membrane.


COPI-coated vesicle

description: A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.


Golgi vesicle transport

description: The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.


regulation of vesicle size

description: Any process that modulates the size of a vesicle.


regulation of actin nucleation

description: Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.


renal water absorption

description: A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


postsynaptic endocytic zone

description: A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins.


opsin binding

description: Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.


opsin transport

description: The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.


name: branching involved in labyrinthine layer morphogenesis

description: The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.


name: negative regulation of myeloid dendritic cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.


name: negative regulation of chronic inflammatory response to antigenic stimulus

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


background adaptation

description: Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity.


Smc5-Smc6 complex

description: A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.


mediator complex binding

description: Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


autophagosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome.


ErbB-2 class receptor binding

description: Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2.


name: chemorepulsion involved in interneuron migration from the subpallium to the cortex

description: The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.


name: regulation of store-operated calcium entry

description: Any process that modulates the frequency, rate or extent of store-operated calcium entry.


name: phagosome-lysosome fusion involved in apoptotic cell clearance

description: The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance.


name: co-transcriptional gene silencing by RNA interference machinery

description: A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin.


cellular response to fatty acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.


mammary gland morphogenesis

description: The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


name: negative regulation of type 2 immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.


name: positive regulation of isotype switching to IgE isotypes

description: Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes.


name: negative regulation of macrophage fusion

description: Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion.


name: epithelial cell of stratum germinativum of esophagus

description: A basal cell that is part of the epithelium of esophagus.


name: inositol trisphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


name: regulation of insulin-like growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.


somatotropin secreting cell development

description: The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.


name: positive regulation of inositol trisphosphate biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


prolactin metabolic process

description: The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals.


thyroid-stimulating hormone secretion

description: The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary.


name: positive regulation of growth hormone secretion

description: Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.


luteinizing hormone secretion

description: The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.


follicle-stimulating hormone secretion

description: The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.


name: synaptic transmission involved in micturition

description: The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body.


prolactin receptor binding

description: Binding to a prolactin receptor.


name: regulation of receptor signaling pathway via JAK-STAT

description: Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.


growth hormone receptor binding

description: Binding to a growth hormone receptor.


name: positive regulation of glucose transmembrane transport

description: Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: regulation of intracellular steroid hormone receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


name: GHR_MOUSE Growth hormone receptor (sprot)

description: A growth hormone receptor that is encoded in the genome of mouse.


peptide hormone receptor binding

description: Binding to a receptor for a peptide hormone.


subthalamic nucleus development

description: The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function.


name: negative regulation of hormone biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.


olfactory sociosexual communication

description: The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system.


name: ODPA_YEAST Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (sprot)

description: A protein that is a translation product of the PDA1 gene in yeast.


barbed-end actin filament capping

description: The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.


negative regulation of cytokinesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.


CTDK-1 complex

description: A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638).


name: positive regulation of DNA-templated transcription, elongation

description: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


name: positive regulation of translational fidelity

description: Any process that increases the ability of the translational apparatus to interpret the genetic code.


skeletal muscle fiber differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.


notochord cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate.


endocardium morphogenesis

description: The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


intermediate mesoderm development

description: The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.


name: mesodermal to mesenchymal transition involved in gastrulation

description: The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation.


name: positive regulation of calcium ion import

description: Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


name: positive regulation of enamel mineralization

description: Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.


name: negative regulation of chondrocyte proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.


ameloblast differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ.


name: cellular response to cell-matrix adhesion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.


name: mandibular condyle articular cartilage development

description: The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure.


name: negative regulation of growth plate cartilage chondrocyte proliferation

description: Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


S-shaped body morphogenesis

description: The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron.


name: negative regulation of Arp2/3 complex-mediated actin nucleation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.


name: negative regulation of humoral immune response mediated by circulating immunoglobulin

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.


name: focal adhesion kinase 1, initiator methionine removed phosphorylated 1 (mouse)

description: A focal adhesion kinase 1, initiator methionine removed phosphorylated 1 in mouse. UniProtKB:P34152, 2-1052, Tyr-397, MOD:00048.


name: focal adhesion kinase 1, initiator methionine removed unphosphorylated 1 (mouse)

description: A focal adhesion kinase 1, initiator methionine removed form (mouse) that lacks phosphorylation on the residue at the position equivalent to Tyr-397 of the amino acid sequence represented by UniProtKB:Q05397-1. Example: UniProtKB:Q05397-1, 2-1052, Tyr-397, PR:000026291.


name: PHAG1_HUMAN Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (sprot)

description: A phosphoprotein associated with glycosphingolipid-enriched microdomains 1 that is encoded in the genome of human.


name: NDUS3_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (sprot)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial that is encoded in the genome of human.


name: LETM1_HUMAN Mitochondrial proton/calcium exchanger protein (sprot)

description: A mitochondrial proton/calcium exchanger protein that is encoded in the genome of human.


name: GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial (sprot)

description: A serine hydroxymethyltransferase, mitochondrial that is encoded in the genome of human.


name: CH10_HUMAN 10 kDa heat shock protein, mitochondrial (sprot)

description: A 10 kDa heat shock protein, mitochondrial that is encoded in the genome of human.


name: NDUA5_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (sprot)

description: An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 that is encoded in the genome of human.


KTN1_HUMAN Kinectin (sprot)

A kinectin that is encoded in the genome of human.


name: ELMO2_HUMAN Engulfment and cell motility protein 2 (sprot)

description: An engulfment and cell motility protein 2 that is encoded in the genome of human.


type D cell of stomach

description: A type D cell found in the stomach.


cyclin D2-CDK4 complex

description: A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: cellular response to phorbol 13-acetate 12-myristate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus.


cellular response to ionomycin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.


cyclin D2-CDK6 complex

description: A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


response to 5-fluorouracil

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.


cyclin A1-CDK2 complex

description: A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin E1-CDK2 complex

description: A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin E2-CDK2 complex

description: A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin A2-CDK2 complex

description: A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: positive regulation of DNA-templated DNA replication initiation

description: Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.


regulation of cell-matrix adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.


description: Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


description: Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

description: Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.


description: Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol.


name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

description: Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.


description: Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.


name: dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity

description: Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.


description: Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol = H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol.


name: lumenal side of endoplasmic reticulum membrane

description: The side (leaflet) of the plasma membrane that faces the lumen.


An alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


An alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


dolichyl beta-D-glucosyl phosphate(1-)

Conjugate base of dolichyl beta-D-glucosyl phosphate arising from deprotonation of the free OH group of the phosphate.


Dianion of N,N'-diacetylchitobiosyldiphosphodolichol.


Dianion of N-acetyl-D-glucosaminyldiphosphodolichol.


An alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


An alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


Conjugate base of beta-D-mannosyldiacetylchitobiosyldiphosphodolichol.


An alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


An alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


An alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


An alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


An alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol)(2-) in which the anomeric centre has alpha-configuration.


maintenance of cell number

description: Any process by which the numbers of cells of a particular type or in a tissue are maintained.


beta-3 adrenergic receptor binding

description: Binding to a beta-3 adrenergic receptor.


regulation of cytoplasmic translation

description: Any process that modulates the frequency, rate or extent of cytoplasmic translation.


sterol homeostasis

description: Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.


name: protein serine/threonine phosphatase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.


name: positive regulation of protein dephosphorylation

description: Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.


name: negative regulation of protein dephosphorylation

description: Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.


name: negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

description: Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.


peroxisome inheritance

description: The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p.


vesicle transport along actin filament

description: Movement of a vesicle along an actin filament, mediated by motor proteins.


polarisome

description: Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.


sensory perception of bitter taste

description: The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


sensory perception of umami taste

description: The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process.


sensory perception of sweet taste

description: The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


name: negative regulation of calcineurin-mediated signaling

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signaling.