name: negative regulation of osteoclast differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.


odontogenesis

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.


tooth mineralization

description: The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum.


name: calcitonin gene-related peptide 1 (mouse)

description: A calcitonin gene-related peptide 1 that is encoded in the genome of mouse.


lumbar region of vertebral column

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Subdivision of vertebral column that corresponds to the lumbar subdivision of the body, containing the lumbar vertebrae.


cellular response to sodium phosphate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus.


negative regulation of bone resorption

description: Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.


determination of adult lifespan

description: The pathways that regulate the duration of the adult phase of the life-cycle of an animal.


aorta development

description: The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.


artery development

description: The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.


vitamin D3 metabolic process

description: The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.


tooth eruption

description: The tooth development process in which the teeth enter the mouth and become visible.


name: odontogenesis of dentin-containing tooth

description: The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.


endochondral ossification

description: Replacement ossification wherein bone tissue replaces cartilage.


name: embryonic skeletal limb joint morphogenesis

description: The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.


proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


embryonic skeletal joint development

description: The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.


regulation of ossification

description: Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.


proteoglycan metabolic process

description: The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


name: negative regulation of lipid biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.


name: MLXPL_HUMAN Carbohydrate-responsive element-binding protein (sprot)

description: A carbohydrate-responsive element-binding protein that is encoded in the genome of human.


magnesium ion homeostasis

description: Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.


vasodilation

description: An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure.


angiotensin-activated signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: maintenance of blood vessel diameter homeostasis by renin-angiotensin

description: The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.


name: positive regulation of detection of glucose

description: Any process that activates or increases the frequency, rate or extent of detection of glucose.


response to symbiotic bacterium

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.


name: negative regulation of keratinocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.


name: positive regulation of keratinocyte proliferation

description: Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.


GDF15-GFRAL signaling pathway

description: The series of molecular signals initiated by GDF15 binding to GFRAL coreceptor, triggering RET autophosphorylation and activation, in response to stress.


amniotic fluid

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid.


(R)-lactate

An optically active form of lactate having (R)-configuration.


name: VKGC_HUMAN Vitamin K-dependent gamma-carboxylase (sprot)

description: A vitamin K-dependent gamma-carboxylase that is encoded in the genome of human.


SNAP receptor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.


name: negative regulation of insulin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.


name: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

description: A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


GTPase-dependent fusogenic activity

description: A GTPase activity that mediates the joining two lipid bilayers to form a single membrane.


dense core granule

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.


name: regulating synaptic membrane exocytosis protein 2 isoform 1 (mouse)

description: A regulating synaptic membrane exocytosis protein 2 isoform 1 that is encoded in the genome of mouse.


fatty acid metabolic process

description: The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.


response to glucose

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.


name: positive regulation of triglyceride biosynthetic process

description: Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.


cholesterol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


name: regulation of fatty acid metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.


name: regulation of heart rate by chemical signal

description: The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


regulation of SREBP signaling pathway

description: Any process that modulates the frequency, rate or extent of the SREBP signaling pathway.


nitric oxide

A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.


nitric oxide synthase 3

A protein that is a translation product of the human NOS3 gene or a 1:1 ortholog thereof.


name: positive regulation of Notch signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.


leptin-mediated signaling pathway

description: The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.


histone kinase activity

description: Catalysis of the transfer of a phosphate group to a histone.


name: positive regulation of protein phosphorylation

description: Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.


name: negative regulation of protein phosphorylation

description: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.


regulation of protein phosphorylation

description: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.


name: G protein-coupled receptor kinase 6 isoform GRK6A (mouse)

description: A G protein-coupled receptor kinase 6 isoform 1 that is encoded in the genome of mouse.


pharyngeal arch artery morphogenesis

description: The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.


name: regulation of protein localization to cell leading edge

description: Any process that modulates the frequency, rate or extent of protein localization to cell leading edge.


endothelin receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


heart process

description: A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.


name: cardiac neural crest cell migration involved in outflow tract morphogenesis

description: The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.


name: negative regulation of macrophage differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.


name: sporulation resulting in formation of a cellular spore

description: The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction.


cellular response to oleic acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus.


cyanamide metabolic process

description: The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.


name: nuclear factor of activated T-cells, cytoplasmic 2 isoform 4 (mouse)

description: A nuclear factor of activated T-cells, cytoplasmic 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60591-4.


name: krueppel-like factor 4 polyglutamylated 1 (mouse)

description: A krueppel-like factor 4 (mouse) that has been polyglutamylated at the position equivalent to Glu-381 of the amino acid sequence represented by UniProtKB:Q60793. UniProtKB:Q60793, Glu-381, MOD:00207.


name: retinoic acid receptor RXR-beta isoform Short (mouse)

description: A retinoic acid receptor RXR-beta (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28704-2.


name: very-long-chain fatty acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


An acyl-CoA(4-) arising from deprotonation of phosphate and diphosphate functions of stearoyl-CoA.


oleoyl-CoA

An octadecenoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of oleic acid.


name: TECRL_HUMAN Trans-2,3-enoyl-CoA reductase-like (sprot)

description: A steroid 5-alpha-reductase 2-like 2 protein that is encoded in the genome of human.


name: TECR_HUMAN Very-long-chain enoyl-CoA reductase (sprot)

description: A very-long-chain enoyl-CoA reductase that is encoded in the genome of human.


name: negative regulation of peptidyl-serine phosphorylation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.


name: regulation of peptidyl-serine phosphorylation

description: Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.


name: 3-phosphoinositide-dependent protein kinase activity

description: Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


name: negative regulation of insulin receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.


regulation of glucose metabolic process

description: Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.


palmitoyl-CoA 9-desaturase activity

description: Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O.


response to bacterium

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.


white fat cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole.


name: defense response to Gram-positive bacterium

description: Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.


name: monounsaturated fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid.


whirlin isoform m8 (mouse)

A whirlin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80VW5-8.


vestibular hair cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem.


stereocilium

description: An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.


name: TRIO and F-actin-binding protein isoform m5 (mouse)

description: A TRIO and F-actin-binding protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99KW3-5.


name: TRIO and F-actin-binding protein isoform m4 (mouse)

description: A TRIO and F-actin-binding protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99KW3-4.


name: TRIO and F-actin-binding protein isoform m1 (mouse)

description: A TRIO and F-actin-binding protein (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99KW3-1.


stereocilia coupling link

description: A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.


kinocilium

description: A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia.


trans-Golgi network transport vesicle

description: A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.


stereocilium base

description: The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.


stereocilium shaft

description: The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle.


cuticular plate

description: A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.


startle response

description: An action or movement due to the application of a sudden unexpected stimulus.


apical protein localization

description: Any process in which a protein is transported to, or maintained in, apical regions of the cell.


name: detection of mechanical stimulus involved in sensory perception of sound

description: The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.


actin filament bundle assembly

description: The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.


name: inner ear auditory receptor cell differentiation

description: The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell.


inner ear receptor cell differentiation

description: The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound.


whirlin isoform m1 (mouse)

A whirlin (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80VW5-1.


name: NMDA selective glutamate receptor complex

description: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.


name: regulation of postsynaptic membrane neurotransmitter receptor levels

description: Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.


behavioral response to ethanol

description: Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.


ear hair cell

description: A hair cell of the ear that contains the organs of balance and hearing.


stereocilia ankle link complex

description: A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.


USH2 complex

description: A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7.


photoreceptor inner segment

description: The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.


photoreceptor connecting cilium

description: The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.


periciliary membrane compartment

description: A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.


stereocilia ankle link

description: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.


thyroid hormone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


triiodothyronine

An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.


name: positive regulation of multicellular organism growth

description: Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.


regulation of heart contraction

description: Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.


female courtship behavior

description: The behavior of a female, for the purpose of attracting a sexual partner.


type I pneumocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.


name: negative regulation of female receptivity

description: Any process that stops, prevents or reduces the receptiveness of a female to male advances.


T-helper 17 cell differentiation

description: The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.


name: negative regulation of T cell mediated immune response to tumor cell

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell.


name: intestinal epithelial structure maintenance

description: A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.


response to bile acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.


phosphate ion transmembrane transport

description: The process in which a phosphate is transported across a membrane.


name: cellular response to 2,3,7,8-tetrachlorodibenzodioxine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus.


structural molecule activity

description: The action of a molecule that contributes to the structural integrity of a complex.


A indol-3-yl carboxylic acid anion that is the conjugate base of 3-(indol-3-yl)pyruvic acid


A monocarboxylic acid anion that is the conjugate base of 3-(1H-indol-3-yl)propanoic acid.


isolithocholate

A bile acid anion that is the conjugate base of isolithocholic acid, obtained by deprotonation of the carboxy group. The 3beta-hydroxy epimer of lithocholate. It is the major microspecies at pH 7.3.


lithocholate

A bile acid anion that is the conjugate base of lithocholic acid.


1,25-dihydroxyvitamin D3

A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.


A 3-oxo Delta(4)-steroid that is testosterone carrying an additional oxo substituent at position 11.


alitretinoin

A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.


neuron projection terminus

description: The specialized, terminal region of a neuron projection such as an axon or a dendrite.


cone cell pedicle

description: A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL).


name: detection of light stimulus involved in visual perception

description: The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.


name: photoreceptor cell outer segment organization

description: A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.


photoreceptor cell maintenance

description: Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.


intraciliary transport

description: The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.


photoreceptor cell differentiation

description: The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.


ribbon synapse

description: Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.


DHET

An icosanoid obtained by formal dihydroxylation across one of the double bonds of arachidonic acid.


regulation of cell growth

description: Any process that modulates the frequency, rate, extent or direction of cell growth.


name: symbiont-mediated suppression of host type I interferon-mediated signaling pathway

description: A process in which a symbiont interferes with, inhibits or disrupts a type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


protein dephosphorylation

description: The process of removing one or more phosphoric residues from a protein.


name: dolichyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative.


name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.


dolichol kinase activity

description: Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate.


Major microspecies at pH 7.3.


D-pantetheine 4'-phosphate(2-)

Pantetheine 4'-phosphate(2-) with D (R) configuration at the 2' position. The dianion formed from D-pantetheine 4'-phosphate by deprotonation of the phosphate group; major microspecies at pH 7.3.


4-phospho-D-erythronic acid

The D-enantiomer of 4-phosphoerythronic acid.


fructose 1-phosphate

A ketohexose monophosphate consisting of fructose having a phosphate group located at the 1-position


pantetheine

An amide obtained by formal condensation of the carboxy group of pantothenic acid and the amino group of cysteamine.


Dianion of 3'-dephospho-CoA.


ditrans,polycis-polyprenol

A polyprenol in which all linkages of the isoprene units are cis, except for the two furthest from the hydroxy group which are trans.


name: purine deoxyribonucleotide metabolic process

description: The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: PTPRM_HUMAN Receptor-type tyrosine-protein phosphatase mu (sprot)

description: A receptor-type tyrosine-protein phosphatase mu that is encoded in the genome of human.


name: PR15A_HUMAN Protein phosphatase 1 regulatory subunit 15A (sprot)

description: A protein phosphatase 1 regulatory subunit 15A that is encoded in the genome of human.


name: PR15B_HUMAN Protein phosphatase 1 regulatory subunit 15B (sprot)

description: A protein phosphatase 1 regulatory subunit 15B that is encoded in the genome of human.


liver parenchyma

description: The functional units of the liver including the lobules.


hydroxyisourate hydrolase activity

description: Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+.


description: Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2.


urate oxidase activity

description: Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide.


protein transporter activity

description: Directly binding to a specific protein and delivering it to a specific cellular location.


name: M3TYJ4_PIG DNA replication licensing factor MCM6 (trembl)


name: PEX1_HUMAN Peroxisomal ATPase PEX1 (sprot)

description: A peroxisomal ATPase PEX1 that is encoded in the genome of human.


name: PEX6_HUMAN Peroxisomal ATPase PEX6 (sprot)

description: A peroxisomal ATPase PEX6 that is encoded in the genome of human.


EET

An icosanoid obtained by formal epoxidation of one of the double bonds of arachidonic acid.


negative regulation of cell growth

description: Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.


name: long-chain fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


lipoxygenase pathway

description: The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.


epoxygenase P450 pathway

description: The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids.


5,6-epoxyeicosatrienoic acid

An EET obtained by formal epoxidation of the 5,6-double bond of arachidonic acid.


An epoxy fatty acid consisting of (4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid having an epoxy group located at the 16,17-position. An intermediate lipid in specialized proresolving mediators.


An epoxy fatty acid consisting of (4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid having an epoxy group at the 13,14-position. An intermediate lipid in specialized proresolving mediators


A polyunsaturated fatty acid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoic acid having an epoxy group across positions 16 and 17.


A metabolite of docosahexaenoic acid that can be converted to 17(S)-RvD1 or 17(S)-RvD2


A metabolite of docosahexaenoic acid that can be converted to 17(S)-RvD3 or 17(S)-RvD4


An epoxy fatty acid that is (7E,9E,11Z,14Z,16E)-icosa-7,9,11,14,16-pentaenoic acid carrying an epoxy group at position 5S and a hydroxy group at position 18S. It is an intermediate in resolvin E1 biosynthesis.


A hydroxydocosahexaenoic acid that is (4Z,9E,11E,13Z,15E,19Z)-docosa-4,9,11,13,15,19-hexaenoic acid carrying an epoxy group at position 7S and a hydroxy group at position 17R. It is a metabolite of docosahexaenoic acid, and serves as a precursor to D-resolvins.


An epoxy fatty acid that is (6E,8E,10Z,13Z,15E,19Z)-docosa-6,8,10,13,15,19-hexaenoic acid which is carrying an epoxy group at position 4S and a hydroxy group at position 17R. It is a metabolite of docosahexaenoic acid that can be converted to a D-resolvin.


The 18(R) stereoisomer of the epoxy-HEPE intermediate in RvE1 biosynthesis


An epoxydocosapentaenoic acid (7Z,9E,11E,16Z,19Z)-docosapentaenoic acid in which the epoxy group is located at the 13,14-position. An intermediate in the specialised proresolving mediators


A docosanoid that is (9E,11E,13Z,15E,19Z)-docosapentaenoic acid carrying an epoxy group across positions 7 and 8 as well as a hydroxy substituent at position 17.  An intermediate of specialised proresolving mediators.


A (4Z,7Z,10Z,13Z,19Z)-16,17-epoxydocosapentaenoic acid in which the chiral centres at positions 16 and 17 both have S-configuration. An intermediate of specialized proresolving mediators


An EET obtained by formal epoxidation of the 8,9-double bond of arachidonic acid.


An EET obtained by formal epoxidation of the 11,12-double bond of arachidonic acid.


An EET obtained by formal epoxidation of the 14,15-double bond of arachidonic acid.


maresin 2

A dihydroxydocosahexaenoic acid that is (4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 13R- and 14S-positions.


A dihydroxydocosahexaenoic acid that is (4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at the 7R- and 14S-positions.


aspirin-triggered protectin D1

A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17R-stereoisomer).


protectin D1

A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1


resolvin D1

A resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7, 8, and 17 positions (the 7S,8R,17S-stereoisomer).


(18S)-resolvin E1

A resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18S stereoisomer).


resolvin E1

A resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer).


resolvin D2

A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer).


A DHET obtained by formal dihydroxylation across the 11,12-double bond of arachidonic acid.


aspirin-triggered resolvin D1

A member of the class of resolvins that consists of docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid carrying three hydroxy substituents at positions 7, 8, and 17 (the 7S,8R,17S-stereoisomer).


A DHET obtained by formal dihydroxylation across the 8,9-double bond of arachidonic acid.


A DHET obtained by formal dihydroxylation across the 14,15-double bond of arachidonic acid.


aspirin-triggered resolvin D2

A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17R-stereoisomer).


aspirin-triggered resolvin D3

A member of the class of resolvins that is (5Z,7E,9E,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 11 and 17 (the 4S,11R,17R-stereoisomer)


aspirin-triggered resolvin D4

A member of the class of resolvins that is (6E,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 5 and 17 (the 4S,5R,17R-stereoisomer).


resolvin D3

A member of the class of resolvins that is (5Z,7E,9E,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 11 and 17 (the 4S,11R,17S-stereoisomer).


resolvin D4

A member of the class of resolvins that is (6E,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 5 and 17 (the 4S,5R,17S-stereoisomer).


A docosanoid that is (8E,10E,12Z,16Z,19Z)-docosapentaenoic acid carrying two hydroxy substituents at positions 7R and 14S. An intermediate of specialised proresolving mediators.


A docosanoid that is (7Z,9E,11E,16Z,19Z)-docosapentaenoic acid carrying two hydroxy substituents at positions 13 and 14. An intermediate of specialised proresolving mediators.


A dihydroxydocosapentaenoic acid (DiHDPE) that is (7Z,11E,13E,15Z,19Z)-docosapentaenoic acid in which the hydrogens at the 10 pro-R and 17 pro-S positions have been replaced by hydroxy groups. It is an intermediate of specialized proresolving mediators.


A dihydroxydocosapentaenoic acid (DiHDPE) that is (7Z,10Z,13E,14E,19Z)-docosapentaenoic acid carrying two hydroxy substituents at the 16 and 17-S positions. It is an intermediate of specialised proresolving mediators.


A docosanoid that is (15E,19Z)-docosa-9,11,13,15,19-pentaenoic acid carrying three hydroxy substituents at positions 7S, 8 and 17S. An intermediate of specialised proresolving mediators


A docosanoid that is (14E,19Z)-docosa-8,10,12,14,19-pentaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17. An intermediate of specialised proresolving mediators


A DHET obtained by formal dihydroxylation across the 5,6-double bond of arachidonic acid.


CP1A2_HUMAN Cytochrome P450 1A2 (sprot)

A cytochrome P450 1A2 that is encoded in the genome of human.


CP1A1_HUMAN Cytochrome P450 1A1 (sprot)

A cytochrome P450 1A1 that is encoded in the genome of human.


CP1B1_HUMAN Cytochrome P450 1B1 (sprot)

A cytochrome P450 1B1 that is encoded in the genome of human.


CP2C8_HUMAN Cytochrome P450 2C8 (sprot)

A cytochrome P450 2C8 that is encoded in the genome of human.


CP2C9_HUMAN Cytochrome P450 2C9 (sprot)

A cytochrome P450 2C9 that is encoded in the genome of human.


name: CP2CJ_HUMAN Cytochrome P450 2C19 (sprot)

description: A cytochrome P450 2C19 that is encoded in the genome of human.


CP2J2_HUMAN Cytochrome P450 2J2 (sprot)

A cytochrome P450 2J2 that is encoded in the genome of human.


methylation

description: The process in which a methyl group is covalently attached to a molecule.


axis elongation

description: The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.


name: regulation of mRNA cis splicing, via spliceosome

description: Any process that modulates the frequency, rate or extent of mRNA cis splicing, via spliceosome.


neural plate development

description: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.


paraxial mesoderm development

description: The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.


splicing factor binding

description: Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA.


notochord morphogenesis

description: The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.


convergent extension

description: The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis.


localization of cell

description: Any process in which a cell is transported to, and/or maintained in, a specific location.


name: convergent extension involved in axis elongation

description: The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.


determination of dorsal identity

description: Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


hypothalamus development

description: The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.


name: positive regulation of fibroblast growth factor receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.


name: anterior/posterior axis specification, embryo

description: The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.


Spemann organizer formation

description: Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan.


name: determination of left/right asymmetry in lateral mesoderm

description: The establishment of the lateral mesoderm with respect to the left and right halves.


epiboly

description: The expansion of one cell sheet over other cells or yolk.


embryonic viscerocranium morphogenesis

description: The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.


regulation of nodal signaling pathway

description: Any process that modulates the frequency, rate or extent of nodal signaling pathway.


name: neural crest cell migration involved in sympathetic nervous system development

description: Any neural crest cell migration that is involved in sympathetic nervous system development.


protein localization to vacuole

description: A process in which a protein is transported to, or maintained at, a location in a vacuole.


name: negative regulation of defense response to virus

description: Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.


name: positive regulation of innate immune response

description: Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.


name: ribosome-associated ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein.


name: protein localization to phagocytic vesicle

description: A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle.


vesicle-mediated transport

description: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.


proteasome localization

description: Any process in which the proteasome is transported to, or maintained in, a specific location.


regulation of protein complex stability

description: Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly.


name: negative regulation of non-canonical NF-kappaB signal transduction

description: Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade.


name: protein import into peroxisome matrix, docking

description: The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane.


pexophagy

description: The selective autophagy process in which a peroxisome is degraded by macroautophagy.


name: positive regulation of lysosome organization

description: Any process that activates or increases the frequency, rate or extent of lysosome organization.


name: protein targeting to lysosome involved in chaperone-mediated autophagy

description: The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor.


negative regulation of viral life cycle

description: Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle.


name: negative regulation of toll-like receptor 4 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


name: negative regulation of cytoplasmic pattern recognition receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway.


protein ufmylation

description: Covalent attachment of the ubiquitin-like protein UFM1 to another protein.


name: negative regulation of signal transduction by p53 class mediator

description: Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.


negative regulation of hippo signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.


protein exit from endoplasmic reticulum

description: The directed movement of proteins from the endoplasmic reticulum.


cytosolic ciliogenesis

description: The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.


P-body assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


aggrephagy

description: The selective degradation of protein aggregates by macroautophagy.


microtubule-based movement

description: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.


name: early endosome to recycling endosome transport

description: The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.


protein localization to cleavage furrow

description: A process in which a protein is transported to, or maintained in, a location within a cleavage furrow.


name: dosage compensation by hyperactivation of X chromosome

description: Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster.


early endosome to Golgi transport

description: The directed movement of substances from early endosomes to the Golgi.


endosomal vesicle fusion

description: The homotypic fusion of endocytic vesicles to form or add to an early endosome.


ribosomal large subunit binding

description: Binding to a large ribosomal subunit.


Rac protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal.


protein lysine deacetylase activity

description: Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein].


protein-RNA adaptor activity

description: The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way.


alpha-aminoacyl-tRNA binding

description: Binding to an alpha-aminoacyl-tRNA.


description: Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.


name: histone H3K36 trimethyltransferase activity

description: Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3.


lipid transfer activity

description: Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids.


cargo adaptor activity

description: Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery.


dynein complex binding

description: Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.


BBSome binding

description: Binding to a BBSome complex.


nuclear pore

description: A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.


cleavage furrow

description: The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.


P-body

description: A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.


autophagosome membrane

description: The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.


fungal-type vacuole

description: A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.


PML body

description: A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.


phagophore assembly site

description: Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.


name: cytoplasmic side of endoplasmic reticulum membrane

description: The side (leaflet) of the plasma membrane that faces the cytoplasm.


postsynaptic specialization membrane

description: The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.


AIM2 inflammasome complex

description: An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.


endocytic vesicle membrane

description: The lipid bilayer surrounding an endocytic vesicle.


early endosome membrane

description: The lipid bilayer surrounding an early endosome.


X chromosome

description: The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.


mitotic telophase

description: The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.


IPO9_HUMAN Importin-9 (sprot)

An importin-9 that is encoded in the genome of human.


name: leucine-rich repeat-containing protein 49 isoform h4 (human)

description: A leucine-rich repeat-containing protein 49 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUZ0-4.


name: TPGS2_HUMAN Tubulin polyglutamylase complex subunit 2 (sprot)

description: A tubulin polyglutamylase complex subunit 2 that is encoded in the genome of human.


name: LRC49_HUMAN Leucine-rich repeat-containing protein 49 (sprot)

description: A leucine-rich repeat-containing protein 49 that is encoded in the genome of human.


name: TPGS1_HUMAN Tubulin polyglutamylase complex subunit 1 (sprot)

description: A tubulin polyglutamylase complex subunit 1 that is encoded in the genome of human.


PML_HUMAN Protein PML (sprot)

A transcription factor PML that is encoded in the genome of human.


name: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform h2 (human)

description: A serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16298-2.


cytoplasmic exosome (RNase complex)

description: A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.


name: autophagy-related protein 2 homolog A isoform h4 (human)

description: An autophagy-related protein 2 homolog A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q2TAZ0-5.


name: ATG2B_HUMAN Autophagy-related protein 2 homolog B (sprot)

description: An autophagy-related protein 2 homolog B that is encoded in the genome of human.


The trianion of a 1-phosphatidyl-1D-myo-inositol 3-phosphate; major species at pH 7.3.


name: UFM1_HUMAN Ubiquitin-fold modifier 1 (sprot)

description: A ubiquitin-fold modifier 1 that is encoded in the genome of human.


name: BBS2_HUMAN Bardet-Biedl syndrome 2 protein (sprot)

description: A Bardet-Biedl syndrome 2 protein that is encoded in the genome of human.


name: BBS5_HUMAN Bardet-Biedl syndrome 5 protein (sprot)

description: A Bardet-Biedl syndrome 5 protein that is encoded in the genome of human.


name: DC1L1_HUMAN Cytoplasmic dynein 1 light intermediate chain 1 (sprot)

description: A cytoplasmic dynein 1 light intermediate chain 1 that is encoded in the genome of human.


dynein complex

description: Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.


name: RAB14_HUMAN Ras-related protein Rab-14 (sprot)

description: A Ras-related protein Rab-14 that is encoded in the genome of human.


name: RAB4B_HUMAN Ras-related protein Rab-4B (sprot)

description: A Ras-related protein Rab-4B that is encoded in the genome of human.


proteasome regulatory particle

description: A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex.


Arp2/3 protein complex

description: A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.


CYH1_MOUSE Cytohesin-1 (sprot)

A cytohesin-1 that is encoded in the genome of mouse.


name: M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (sprot)

description: A mitogen-activated protein kinase kinase kinase 14 that is encoded in the genome of mouse.


name: cytosolic [4Fe-4S] assembly targeting complex

description: A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in the cytoplasm and nucleus. In humans it consists of MMS19, CIAO1, CIAO2A/CIAO2B, CIAO3. MMS19, CIAO1 and CIAO2A/CIAO2B form a tight 'core' complex, whereas CIAO3 is an 'external' component of this complex.


Ski complex

description: A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.


name: CSTP1_HUMAN Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 (sprot)

description: A centriolar satellite-associated tubulin polyglutamylase complex regulator 1 that is encoded in the genome of human.


name: WIPI1_HUMAN WD repeat domain phosphoinositide-interacting protein 1 (sprot)

description: A WD repeat domain phosphoinositide-interacting protein 1 that is encoded in the genome of human.


name: BILF1_EBVB9 G-protein coupled receptor BILF1 (sprot)


name: IQCB1_HUMAN IQ calmodulin-binding motif-containing protein 1 (sprot)

description: An IQ calmodulin-binding motif-containing protein 1 that is encoded in the genome of human.


name: TNR6A_HUMAN Trinucleotide repeat-containing gene 6A protein (sprot)

description: A trinucleotide repeat-containing gene 6A protein that is encoded in the genome of human.


name: RUFY1_HUMAN RUN and FYVE domain-containing protein 1 (sprot)

description: A RUN and FYVE domain-containing protein 1 that is encoded in the genome of human.


name: PCM1_HUMAN Pericentriolar material 1 protein (sprot)

description: A pericentriolar material 1 protein that is encoded in the genome of human.


name: PEX26_HUMAN Peroxisome assembly protein 26 (sprot)

description: A peroxisome assembly protein 26 that is encoded in the genome of human.


name: MARH7_HUMAN E3 ubiquitin-protein ligase MARCHF7 (sprot)

description: An E3 ubiquitin-protein ligase MARCHF7 that is encoded in the genome of human.


name: MTA_HHV8P Post-transcriptional regulator MTA (sprot)


name: ZDH19_HUMAN Palmitoyltransferase ZDHHC19 (sprot)

description: A palmitoyltransferase ZDHHC19 that is encoded in the genome of human.


ubiquitin ligase complex

description: A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.


name: AN_HHV8P Shutoff alkaline exonuclease (sprot)


axis specification

description: The establishment, maintenance and elaboration of a pattern along a line or around a point.


name: negative regulation of receptor internalization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.


afferent neuron

description: A neuron which conveys sensory information centrally from the periphery.


central nervous system myelination

description: The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.


axon regeneration

description: The regrowth of axons following their loss or damage.


stem cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.


myoblast fate specification

description: The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


cellular response to virus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


ATP metabolic process

description: The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.


regulation of neuron differentiation

description: Any process that modulates the frequency, rate or extent of neuron differentiation.


bronchiole development

description: The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi.


name: L-glutamate import across plasma membrane

description: The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol.


transmission of nerve impulse

description: The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.


name: specification of segmental identity, mandibular segment

description: The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


chordate pharynx development

description: The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure.


name: growth plate cartilage chondrocyte proliferation

description: The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.


regulation of cell cycle checkpoint

description: Any process that modulates the frequency, rate or extent of cell cycle checkpoint.


spinal cord development

description: The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.


cementum mineralization

description: The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum.


collagen-activated signaling pathway

description: The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


oligodendrocyte apoptotic process

description: Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.


sympathetic neuron axon guidance

description: The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.


name: specification of segmental identity, maxillary segment

description: The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


semaphorin-plexin signaling pathway

description: The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.


diphosphate metabolic process

description: The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid.


regulation of hydrolase activity

description: Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.


protein nitrosylation

description: The covalent addition of a nitric oxide group to an amino acid within a protein.


synaptic signaling

description: Cell-cell signaling to, from or within a synapse.


mitochondrial transport

description: Transport of substances into, out of or within a mitochondrion.


testosterone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5.


protein glucuronidation

description: The modification of a protein by amino acid glucuronidation.


presumptive endoderm

description: Presumptive structure of the blastula that will develop into endoderm.


striated muscle cell

description: Muscle cell which has as its direct parts myofilaments organized into sarcomeres.


melanocyte of skin

description: A melanocyte that is part of the skin of body.


calvarial osteoblast

description: Any osteoblast that is part of a skull.


cementoblast

description: Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell.


growth plate cartilage chondrocyte

description: Any chondrocyte that is part of some growth plate cartilage.


aortic smooth muscle cell

description: A smooth muscle cell of the aorta.


stromal cell of bone marrow

description: A stromal cell that is part_of a bone marrow.


sympathetic ganglion

description: A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.


gray matter

description: A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.


inflammatory macrophage

description: An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity.


mammotroph

description: An acidophilic cell of the anterior pituitary that produces prolactin.


ventral tegmental nucleus

description: A nucleus of brain that is part of a ventral tegmental area.


name: Oreochromis aureus x Oreochromis niloticus


hydrogen peroxide

An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.


dinoprostone

Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.


heart contraction

description: The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.


abducens nucleus development

description: The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.


name: vascular associated smooth muscle cell migration

description: The orderly movement of a vascular associated smooth muscle cell from one site to another.


name: vascular associated smooth muscle cell proliferation

description: The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


microglia differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system.


regulation of blood pressure

description: Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.


lymphocyte migration

description: The movement of a lymphocyte within or between different tissues and organs of the body.


podocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells.


bone morphogenesis

description: The process in which bones are generated and organized.


endochondral bone morphogenesis

description: The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.


name: hematopoietic stem cell migration to bone marrow

description: The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.


name: growth plate cartilage chondrocyte growth

description: The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another.


name: sensory perception of temperature stimulus

description: The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


motor neuron apoptotic process

description: Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.


eosinophil mediated immunity

description: Any process involved in the carrying out of an immune response by an eosinophil.


skeletal myofibril assembly

description: The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.


rhythmic behavior

description: The specific behavior of an organism that recur with measured regularity.


sarcomere organization

description: The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


facial nucleus development

description: The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.


hypoglossal nucleus development

description: The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure.


response to Gram-positive bacterium

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium.


B-1 B cell homeostasis

description: The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


name: response to platelet-derived growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.


microglial cell migration

description: The orderly movement of a microglial cell from one site to another.


name: immunoglobulin production involved in immunoglobulin-mediated immune response

description: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.


name: sensory perception of mechanical stimulus

description: The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


axonogenesis involved in innervation

description: The neurite development process that generates a long process of a neuron, as it invades a target tissue.


sinoatrial node development

description: The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.


ductus arteriosus closure

description: The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.


fibroblast proliferation

description: The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.


response to pain

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.


response to mechanical stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.


CCN3_HUMAN CCN family member 3 (sprot)

A protein NOV that is encoded in the genome of human.


brain-derived neurotrophic factor

A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof.


CP1A5_CHICK Cytochrome P450 1A5 (sprot)

A protein that is a translation product of the CYP1A5 gene in chicken.


cytochrome P450 1A2

A protein that is a translation product of the human CYP1A2 gene or a 1:1 ortholog thereof.


name: vascular endothelial growth factor A, long form

description: A protein that is a translation product of the human VEGFA gene or a 1:1 ortholog thereof.


name: steroidogenic acute regulatory protein, mitochondrial

description: A protein that is a translation product of the human STAR gene or a 1:1 ortholog thereof.


translocator protein

A protein that is a translation product of the human TSPO gene or a 1:1 ortholog thereof.


name: HESX1_HUMAN Homeobox expressed in ES cells 1 (sprot)

description: A homeobox expressed in ES cells 1 that is encoded in the genome of human.


name: SIX3_HUMAN Homeobox protein SIX3 (sprot)

description: A homeobox protein SIX3 that is encoded in the genome of human.


name: peroxisome proliferator activated receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a ligand binding to an intracellular peroxisome proliferator activated receptor (alpha, beta or gamma) of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: HES1_HUMAN Transcription factor HES-1 (sprot)

description: A transcription factor HES-1 that is encoded in the genome of human.


name: HNF6_HUMAN Hepatocyte nuclear factor 6 (sprot)

description: A hepatocyte nuclear factor 6 that is encoded in the genome of human.


name: HNF1B_HUMAN Hepatocyte nuclear factor 1-beta (sprot)

description: A hepatocyte nuclear factor 1-beta that is encoded in the genome of human.


name: ONEC3_HUMAN One cut domain family member 3 (sprot)

description: An one cut domain family member 3 that is encoded in the genome of human.


NGN3_HUMAN Neurogenin-3 (sprot)

A neurogenin-3 that is encoded in the genome of human.


name: PDX1_HUMAN Pancreas/duodenum homeobox protein 1 (sprot)

description: A pancreas/duodenum homeobox protein 1 that is encoded in the genome of human.


name: PTF1A_HUMAN Pancreas transcription factor 1 subunit alpha (sprot)

description: A pancreas transcription factor 1 subunit alpha that is encoded in the genome of human.


name: nuclear receptor subfamily 5 group A member 2 isoform h2 (human)

description: A nuclear receptor subfamily 5 group A member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00482-1.


name: NKX61_HUMAN Homeobox protein Nkx-6.1 (sprot)

description: A homeobox protein Nkx-6.1 that is encoded in the genome of human.


name: PAX4_HUMAN Paired box protein Pax-4 (sprot)

description: A paired box protein Pax-4 that is encoded in the genome of human.


name: NKX22_HUMAN Homeobox protein Nkx-2.2 (sprot)

description: A homeobox protein Nkx-2.2 that is encoded in the genome of human.


name: NDF1_HUMAN Neurogenic differentiation factor 1 (sprot)

description: A neurogenic differentiation factor 1 that is encoded in the genome of human.


name: INSM1_HUMAN Insulinoma-associated protein 1 (sprot)

description: An insulinoma-associated protein 1 that is encoded in the genome of human.


name: GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human.


name: IAPP_HUMAN Islet amyloid polypeptide (sprot)

description: An islet amyloid polypeptide that is encoded in the genome of human.


name: HNF4G_HUMAN Hepatocyte nuclear factor 4-gamma (sprot)

description: A hepatocyte nuclear factor 4-gamma that is encoded in the genome of human.


name: pyruvate kinase PKLR isoform L-type (human)

description: A pyruvate kinase PKLR isoform L-type that is encoded in the genome of human.


name: FOXA3_HUMAN Hepatocyte nuclear factor 3-gamma (sprot)

description: A hepatocyte nuclear factor 3-gamma that is encoded in the genome of human.


name: hepatocyte nuclear factor 4-alpha isoform hHNF4-Alpha-7 (human)

description: A hepatocyte nuclear factor 4-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41235-5.


name: hepatocyte nuclear factor 4-alpha isoform hHNF4-Alpha-8 (human)

description: A hepatocyte nuclear factor 4-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41235-6.


name: hepatocyte nuclear factor 4-alpha isoform hHNF4-Alpha-9 (human)

description: A hepatocyte nuclear factor 4-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41235-7.


name: neural plate anterior/posterior regionalization

description: The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.


somite development

description: The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.


retina development in camera-type eye

description: The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.


notochord development

description: The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.


germ cell migration

description: The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.


pronephric glomerulus morphogenesis

description: The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.


adrenal gland development

description: The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.


induction of positive chemotaxis

description: Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.


floor plate development

description: The progression of the floor plate over time from its initial formation until its mature state.


name: lens placode formation involved in camera-type eye formation

description: Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles.


floor plate formation

description: The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage.


name: cardioblast migration to the midline involved in heart field formation

description: The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


prechordal plate formation

description: The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.


name: convergent extension involved in nephron morphogenesis

description: The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron.


hypoblast development

description: The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast.


name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity

description: Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate.


name: EEA1_HUMAN Early endosome antigen 1 (sprot)

description: An early endosome antigen 1 that is encoded in the genome of human.


negative regulation of receptor binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.


brain white matter

description: The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.


GABA-A receptor complex

description: A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).


name: AVR2A_MOUSE Activin receptor type-2A (sprot)

description: An activin receptor type-2A that is encoded in the genome of mouse.


PLXB2_MOUSE Plexin-B2 (sprot)

A plexin-B2 that is encoded in the genome of mouse.


PLXB1_MOUSE Plexin-B1 (sprot)

A plexin-B1 that is encoded in the genome of mouse.


name: TNR9_MOUSE Tumor necrosis factor receptor superfamily member 9 (sprot)

description: A tumor necrosis factor receptor superfamily member 9 that is encoded in the genome of mouse.


LEPR_MOUSE Leptin receptor (sprot)

A leptin receptor that is encoded in the genome of mouse.


NEO1_MOUSE Neogenin (sprot)

A neogenin that is encoded in the genome of mouse.


P2RX7_MOUSE P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of mouse.


TLR4_MOUSE Toll-like receptor 4 (sprot)

A Toll-like receptor 4 that is encoded in the genome of mouse.


PRTG_MOUSE Protogenin (sprot)

A protogenin that is encoded in the genome of mouse.


name: SSR3_MOUSE Somatostatin receptor type 3 (sprot)

description: A somatostatin receptor type 3 that is encoded in the genome of mouse.


name: ACV1B_MOUSE Activin receptor type-1B (sprot)

description: An activin receptor type-1B that is encoded in the genome of mouse.


name: MCHR1_MOUSE Melanin-concentrating hormone receptor 1 (sprot)

description: A melanin-concentrating hormone receptor 1 that is encoded in the genome of mouse.


name: purinergic nucleotide receptor signaling pathway

description: The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: SKIT2_MOUSE Selection and upkeep of intraepithelial T-cells protein 2 (sprot)

description: A selection and upkeep of intraepithelial T-cells protein 2 that is encoded in the genome of mouse.


name: protein localization to mitotic actomyosin contractile ring

description: Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis.


name: protein localization to actin cortical patch

description: A process in which a protein is transported to, or maintained in, an actin cortical patch.


muscle structure development

description: The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.


hepatocyte apoptotic process

description: Any apoptotic process in a hepatocyte, the main structural component of the liver.


foregut-midgut junction

description: An anatomical junctions that overlaps the foregut and midgut.


name: chromodomain-helicase-DNA-binding protein 8 isoform m1 (mouse)

description: A chromodomain-helicase-DNA-binding protein 8 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q09XV5-1.


maintenance of translational fidelity

description: Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.


calcium-ion regulated exocytosis

description: The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.


name: type B pancreatic cell apoptotic process

description: Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.


name: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


name: insulin secretion involved in cellular response to glucose stimulus

description: The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.


glucose transmembrane transport

description: The process in which glucose is transported across a membrane.


NADP metabolic process

description: The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.


positive regulation of exocytosis

description: Any process that activates or increases the frequency, rate or extent of exocytosis.


name: negative regulation of type B pancreatic cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation.