name: proteasomal ubiquitin-independent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin.


name: 18S rRNA aminocarboxypropyltransferase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine.


ubiquitin ligase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.


category: biolink:MacromolecularComplex biolink:MacromolecularMachineMixin biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


pyridoxal biosynthetic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds.


forebrain neuroblast

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any neuroblast (sensu Vertebrata) that is part of some forebrain.


atrioventricular canal morphogenesis

description: The developmental process by which an atrioventricular canal is generated and organized.


glial cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


name: negative regulation of skeletal muscle tissue growth

description: Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.


medial fin morphogenesis

description: The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming.


proteasome complex disassembly

description: The disaggregation of a proteasome complex into its constituent components.


GTP cyclohydrolase 1

A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof.


glucuronate metabolic process

description: The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.


histone butyryltransferase activity

description: Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone.


peptidyl-lysine butyrylation

description: The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid.


G1 phase

description: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.


mesenchymal stem cell of adipose tissue

description: A mesenchymal stem cell of adipose tissue.


name: positive regulation of telomere maintenance via telomerase

description: Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.


CTRC_MOUSE Chymotrypsin-C (sprot)

A chymotrypsin-C that is encoded in the genome of mouse.


name: NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (sprot)

description: An NAD(P)H dehydrogenase [quinone] 1 that is encoded in the genome of human.


name: AZIN1_HUMAN Antizyme inhibitor 1 (sprot)

description: An antizyme inhibitor 1 that is encoded in the genome of human.


G-protein beta-subunit binding

description: Binding to a G-protein beta subunit.


AMP transmembrane transporter activity

description: Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other.


name: coenzyme A transmembrane transporter activity

description: Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.


glycerophosphate shuttle

description: The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.


kisspeptin receptor binding

description: Binding to a kisspeptin receptor.


regulation of fear response

description: Any process that modulates the frequency, rate or extent of fear response.


olfactory bulb interneuron development

description: The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.


name: cell differentiation involved in salivary gland development

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland.


name: adaptive immune memory response involving T cells and B cells

description: An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response.


granzyme A production

description: The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


RNA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.


Isw1b complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p.


Isw1a complex

description: An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p.


sulfolipid metabolic process

description: The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid.


prechordal mesoderm

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The area of axial mesoderm that develops into the prechordal plate.


homeostasis of number of retina cells

description: Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina.


meiotic spindle pole

description: Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.


name: female germ-line stem cell asymmetric division

description: The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.


name: negative regulation of protein homooligomerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization.


Rpd3L complex

description: A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a two copies of catalytic histone deacetylase subunit (S. pombe Clr6/ S. cerevisiae Rpd3p), an Sds-3 family protein (S. pombe /S. cerevisiae Sds3(p) ), two copies of SIN3 family co-repressor (S. pombe Pst1/ S. cerevisiae Sin3p, a WD repeat protein/ histone chaperone (S. pombe Prw1/ S. cerevisiae Ume1p), and a zf- PHD finger ( S. pombe Png2/ S. cerevisiae Pho23p), plus 4 additional subunits, and associated factors.


Rpd3L-Expanded complex

description: A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.


name: negative regulation of silent mating-type cassette heterochromatin formation

description: Any process that decreases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.


name: negative regulation of rDNA heterochromatin formation

description: Any process that decreases the rate, frequency, or extent of ribosomal DNA heterochromatin formation.


name: protein localization to nuclear envelope

description: A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.


O-acetyl-L-homoserine zwitterion

Zwitterionic form of O-acetyl-L-homoserine having an anionic carboxy group and a protonated alpha-amino group; major species at pH 7.3.


L-homocysteine zwitterion

An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of L-homocysteine; major species at pH 7.3.


name: POTE1_HUMAN Protection of telomeres protein 1 (sprot)

description: A protection of telomeres protein 1 that is encoded in the genome of human.


leptotene

description: The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.


regulation of fertilization

description: Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).


tendon development

description: The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.


microvascular endothelial cell

description: Any blood vessel endothelial cell that is part of a microvascular endothelium.


name: retina vasculature morphogenesis in camera-type eye

description: The process in which the vasculature of the retina is generated and organized.


retina blood vessel maintenance

description: A retina homeostatic process preventing the degeneration of a retina blood vessel.


name: serine family amino acid metabolic process

description: The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.


name: positive regulation of meiotic cell cycle

description: Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.


regulation of filamentous growth

description: Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.


name: positive regulation of triglyceride catabolic process

description: Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.


name: positive regulation of mitotic DNA damage checkpoint

description: Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint.


regulation of spindle assembly

description: Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.


name: positive regulation of trehalose catabolic process

description: Any process that activates or increases the frequency, rate or extent of trehalose catabolic process.


name: protein localization to spindle microtubule

description: A process in which a protein is transported to, or maintained in, a location within a spindle microtubule.


name: protein localization to nuclear periphery

description: A process in which a protein is transported to, or maintained in, a location within the nuclear periphery.


name: negative regulation of DNA replication origin binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding.


name: positive regulation of nuclear cell cycle DNA replication

description: Any process that activates or increases the frequency, rate or extent of the DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.


mitotic sister chromatid biorientation

description: The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression.


name: regulation of protein localization to chromatin

description: Any process that modulates the frequency, rate or extent of protein localization to chromatin.


name: regulation of telomere maintenance via telomerase

description: Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.


name: negative regulation of mitotic actomyosin contractile ring assembly

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly.


name: regulation of budding cell apical bud growth

description: Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding.


name: negative regulation of double-strand break repair via nonhomologous end joining

description: Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining.


spongiotrophoblast layer development

description: The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state.


apolipoprotein binding

description: Binding to an apolipoprotein, the protein component of a lipoprotein complex.


forebrain generation of neurons

description: The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.


external genitalia morphogenesis

description: The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.


name: negative regulation of planar cell polarity pathway involved in pericardium morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis.


name: negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis.


APOB_MOUSE Apolipoprotein B-100 (sprot)

An apolipoprotein B-100 that is encoded in the genome of mouse.


name: regulation of cyclin-dependent protein serine/threonine kinase activity

description: Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.


trimethylamine N-oxide

A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.


name: LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (sprot)

description: A large neutral amino acids transporter small subunit 2 that is encoded in the genome of human.


L-homoarginine

An L-lysine derivative that is the L-enantiomer of homoarginine.


L-2,4-diaminobutyric acid

A 2,4-diaminobutyric acid that has S-configuration.


tilarginine

A L-arginine derivative with a N(omega)-methyl substituent.


name: dichotomous subdivision of terminal units involved in salivary gland branching

description: The process in which a salivary epithelial cord bifurcates at its end.


corneocyte

description: The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus.


name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing

description: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing.


isoaspartate

Formed following deamidation of asparagine or dehydration of aspartic acid via a metastable succinimide (cyclic imide) intermediate, which hydrolyzes to a mixture of aspartyl and isoaspartyl linkages.


NMDA

An aspartic acid derivative having an N-methyl substituent and D-configuration.


Norrin signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state.


name: asymmetric protein localization involved in cell fate determination

description: Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.


name: skeletal muscle satellite cell activation

description: The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.


monocyte proliferation

description: The expansion of a monocyte population by cell division.


name: tRNA threonylcarbamoyladenosine metabolic process

description: The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


name: inorganic cation transmembrane transporter activity

description: Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.


name: alcohol transmembrane transporter activity

description: Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group.


organic hydroxy compound transport

description: The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.


catechol oxidase activity

description: Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones.


name: dopamine biosynthetic process from tyrosine

description: The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine.


name: positive regulation of anaphase-promoting complex-dependent catabolic process

description: Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


fructose 6-phosphate metabolic process

description: The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.


ribonucleoprotein granule

description: A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.


integrin complex

description: A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.


isoleucyl-tRNA aminoacylation

description: The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


glutaminyl-tRNA aminoacylation

description: The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


asparaginyl-tRNA aminoacylation

description: The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA.


leucyl-tRNA aminoacylation

description: The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


valyl-tRNA aminoacylation

description: The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


aminoacyl-tRNA ligase activity

description: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.


histidyl-tRNA aminoacylation

description: The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.


threonyl-tRNA aminoacylation

description: The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.


description: The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


lysyl-tRNA aminoacylation

description: The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.


arginyl-tRNA aminoacylation

description: The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


cysteinyl-tRNA aminoacylation

description: The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


phenylalanine-tRNA ligase complex

description: An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).


phenylalanyl-tRNA aminoacylation

description: The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: eukaryotic translation initiation factor 2 complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex.


regulation of ferroptosis

description: Any process that modulates the frequency, rate or extent of ferroptosis.


dicarboxylic acid transport

description: The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


nicotinate

A pyridinemonocarboxylate that is the conjugate base of nicotinic acid, arising from deprotonation of the carboxy group; major species at pH 7.3.


name: regulation of amacrine cell differentiation

description: Any process that modulates the frequency, rate or extent of amacrine cell differentiation.


ITA2B_HUMAN Integrin alpha-IIb (sprot)

An integrin alpha-IIb that is encoded in the genome of human.


name: positive regulation of epithelial cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.


name: IF4A2_HUMAN Eukaryotic initiation factor 4A-II (sprot)

description: A eukaryotic initiation factor 4A-II that is encoded in the genome of human.


name: regulation of timing of neuron differentiation

description: The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron.


RNA methylation

description: Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.


name: RBM33_HUMAN RNA-binding protein 33 (sprot)

description: An RNA-binding protein 33 that is encoded in the genome of human.


name: negative regulation of single-species biofilm formation in or on host organism

description: Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism.


name: host-mediated regulation of oral microbiota composition

description: The biological process involved in maintaining the steady-state number of cells within a population of free-living cells, such as the bacteria, in the mouth.


name: establishment of centrosome localization

description: The directed movement of the centrosome to a specific location.


name: regulation of proteasomal ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


regulatory B cell

description: A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses.


defecation

description: The expulsion of feces from the rectum.


response to rapamycin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus.


name: respiratory burst involved in inflammatory response

description: A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.


name: multicellular organismal-level chemical homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.


lipid import into cell

description: The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.


cellular lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells.


response to vitamin A

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.


name: triglyceride-rich lipoprotein particle clearance

description: The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


T-helper 17 cell

description: CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17.


glycosylceramide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group.


An  oxysterol that is cholesterol substituted  by hydroxy groups at positions 20 and 22 (the 20R,22R-stereoisomer).


A 7alpha,24-dihydroxycholesterol in which has S configuration at position 24.


The 7alpha-hydroxy derivative of cholesterol.


epsilon DNA polymerase complex

description: A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.


gene conversion

description: A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor. The resulting acceptor sequence is identical to that of the donor.


DNA replication checkpoint signaling

description: A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.


maintenance of DNA repeat elements

description: Any process involved in sustaining the fidelity and copy number of DNA repeat elements.


replication fork arrest

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected.


name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 (mouse)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 in mouse. UniProtKB:Q8BRK8, Thr-172, PR:000026291.


name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 (mouse)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-1 unphosphorylated 1 in mouse. UniProtKB:Q5EG47, Thr-183, PR:000026291.


name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 (mouse)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-2 phosphorylated 1 in mouse. UniProtKB:Q8BRK8, Thr-172, MOD:00047.


name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 (mouse)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-1 phosphorylated 1 in mouse. UniProtKB:Q5EG47, Thr-183, MOD:00047.


response to ionizing radiation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.


name: protein-containing complex stabilizing activity

description: A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex.


name: DNA-dependent protein kinase-DNA ligase 4 complex

description: A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.


DNA-dependent protein kinase activity

description: DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


protein kinase CK2 complex

description: A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.


name: TTI2_HUMAN TELO2-interacting protein 2 (sprot)

description: A TELO2-interacting protein 2 that is encoded in the genome of human.


name: pyrimidine-containing compound metabolic process

description: The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.


name: DGKI_MOUSE Diacylglycerol kinase iota (sprot)

description: A diacylglycerol kinase iota that is encoded in the genome of mouse.


name: regulation of calcium ion-dependent exocytosis

description: Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.


name: CAC1H_MOUSE Voltage-dependent T-type calcium channel subunit alpha-1H (sprot)

description: A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of mouse.


name: TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 (sprot)

description: A transient receptor potential cation channel TRPV1 that is encoded in the genome of mouse.


effector T cell

description: A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response.


sterol O-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.


name: regulation of small GTPase mediated signal transduction

description: Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.


name: negative regulation of activation-induced cell death of T cells

description: Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.


glycerol metabolic process

description: The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.


regulation of phagosome maturation

description: Any process that modulates the frequency, rate or extent of phagosome maturation.


name: regulation of vitamin A metabolic process

description: Any process that modulates the frequency, rate or extent of vitamin A metabolic process.


induction of bacterial agglutination

description: Any process in which infecting bacteria are clumped together by a host organism.


name: water transmembrane transporter activity

description: Enables the transfer of water (H2O) from one side of a membrane to the other.


symbiont-containing vacuole membrane

description: The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont.


adhesion of symbiont to host

description: The attachment of a symbiont to its host via either adhesion molecules, general stickiness, or other mechanisms. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: retinol transmembrane transporter activity

description: Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.


photoreceptor inner segment membrane

description: The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.


N-retinylidenephosphatidylethanolamine

A Schiff base obtained by formal condensation of the aldehyde group of  all-trans-retinal with the amino group of phosphatidylethanolamine.


BETA-IONONE

An ionone that is but-3-en-2-one substituted by a 2,6,6-trimethylcyclohex-1-en-1-yl group at position 4.


An apo carotenoid compound arising from oxidative degradation of the beta,beta-carotene skeleton at the 10'-position.


name: STRA6_HUMAN Receptor for retinol uptake STRA6 (sprot)

description: A receptor for retinol uptake STRA6 that is encoded in the genome of human.


APOM_HUMAN Apolipoprotein M (sprot)

An apolipoprotein M that is encoded in the genome of human.


name: negative regulation of angiotensin-activated signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway.


heat generation

description: Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.


sequestering of triglyceride

description: The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.


specific granule

description: Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.


name: REPS1_HUMAN RalBP1-associated Eps domain-containing protein 1 (sprot)

description: A RalBP1-associated Eps domain-containing protein 1 that is encoded in the genome of human.


name: SGIP1_HUMAN SH3-containing GRB2-like protein 3-interacting protein 1 (sprot)

description: An SH3-containing GRB2-like protein 3-interacting protein 1 that is encoded in the genome of human.


name: EPS15_HUMAN Epidermal growth factor receptor substrate 15 (sprot)

description: An epidermal growth factor receptor substrate 15 that is encoded in the genome of human.


name: GAK_HUMAN Cyclin-G-associated kinase (sprot)

description: A cyclin-G-associated kinase that is encoded in the genome of human.


AUXI_HUMAN Auxilin (sprot)

A putative tyrosine-protein phosphatase auxilin that is encoded in the genome of human.


name: NECP1_HUMAN Adaptin ear-binding coat-associated protein 1 (sprot)

description: An adaptin ear-binding coat-associated protein 1 that is encoded in the genome of human.


SNX18_HUMAN Sorting nexin-18 (sprot)

A sorting nexin-18 that is encoded in the genome of human.


name: NECP2_HUMAN Adaptin ear-binding coat-associated protein 2 (sprot)

description: An adaptin ear-binding coat-associated protein 2 that is encoded in the genome of human.


ITSN2_HUMAN Intersectin-2 (sprot)

An intersectin-2 that is encoded in the genome of human.


SNX9_HUMAN Sorting nexin-9 (sprot)

A sorting nexin-9 that is encoded in the genome of human.


name: RNAS1_HUMAN Ribonuclease pancreatic (sprot)

description: A ribonuclease pancreatic that is encoded in the genome of human.


name: negative regulation of cellular respiration

description: Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration.


name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development

description: The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta.


trophectodermal cell proliferation

description: The proliferation of cells in the trophectoderm.


cochlear nerve

description: A nerve in the head that carries signals from the cochlea of the inner ear to the brain. It is part of the vestibulocochlear nerve, the 8th cranial nerve which is found in higher vertebrates; the other portion of the 8th cranial nerve is the vestibular nerve which carries spatial orientation information from the semicircular canals. The cochlear nerve is a sensory nerve, one which conducts to the brain information about the environment, in this case acoustic energy impinging on the tympanic membrane. The cochlear nerve arises from within the cochlea and extends to the brainstem, where its fibers make contact with the cochlear nucleus, the next stage of neural processing in the auditory system[WP].


xylosyltransferase activity

description: Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.


name: principal sensory nucleus of trigeminal nerve development

description: The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.


name: acetylcholine receptor signaling pathway

description: The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands.


regulation of kinase activity

description: Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


post-embryonic hindlimb morphogenesis

description: The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized.


An alpha-amino acid ester that is the methyl ester of S-[(2E,6E)-farnesyl]-L-cysteine.


bioactive lipid receptor activity

description: Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.


GET complex

description: An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins.


protein folding chaperone complex

description: A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.


name: mRNA regulatory element binding translation repressor activity

description: Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.


protein-RNA complex remodeling

description: The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex.


name: regulation of ribosomal subunit export from nucleus

description: Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus.


regulation of bone resorption

description: Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).


name: anterior lateral line neuromast hair cell development

description: The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.


lateral line ganglion development

description: The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear.


scavenger receptor activity

description: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).


name: oxidised low-density lipoprotein particle clearance

description: The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


name: regulation of glycoprotein biosynthetic process

description: Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.


intestinal stem cell homeostasis

description: Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.


name: regulation of retrograde protein transport, ER to cytosol

description: Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol.


vacuole-ER tethering

description: The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles.


serine 3-dehydrogenase activity

description: Catalysis of the reaction: L-serine + NADP+ = L-alpha-formylglycine + 2 H+ + NADPH.


acetoin metabolic process

description: The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source.


name: D-arabinose 1-dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+.


D-xylose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.


arabinose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose.


F-actin capping protein complex

description: A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.


ornithine metabolic process

description: The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.


mucous neck cell of gastric gland

description: A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach.


A tetrasaccharide consisting of alternating D-glucuronic acid and D-xylosyl residues joined in sequence by (1->3)-linkages. A repeating unit in glycoprotein DAG1


name: FGF23_MOUSE Fibroblast growth factor 23 (sprot)

description: A fibroblast growth factor 23 that is encoded in the genome of mouse.


presynaptic endocytic zone

description: A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.


presynaptic cytoskeleton

description: The portion of the cytoskeleton contained within the presynapse.


trans-synaptic signaling via exosome

description: Transynaptic signaling in which the ligand is carried across the synapse by an exosome.


synaptic vesicle endosomal processing

description: The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.


anterograde axonal protein transport

description: The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.


name: regulation of translation at presynapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.


regulation of synaptic vesicle docking

description: Any process that modulates the frequency, rate or extent of synaptic vesicle docking.


name: structural constituent of presynaptic actin cytoskeleton

description: The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton.


name: trans-synaptic signaling by neuropeptide

description: Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.


presynaptic endocytosis

description: A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.


name: CTBP2_BOVIN C-terminal-binding protein 2 (sprot)


protein O-linked mannosylation

description: The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.


cell tip

description: The region at the end of the longest axis of a cylindrical or elongated cell.


photoreceptor cell terminal bouton

description: A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light.


IL33_MOUSE Interleukin-33 (sprot)

An interleukin-33 that is encoded in the genome of mouse.


name: ANPRB_HUMAN Atrial natriuretic peptide receptor 2 (sprot)

description: An atrial natriuretic peptide receptor 2 that is encoded in the genome of human.


name: ANFC_HUMAN C-type natriuretic peptide (sprot)

description: A C-type natriuretic peptide that is encoded in the genome of human.


embryonic cell (metazoa)

description: A cell of the embryo.


potassium chloride

A metal chloride salt with a K(+) counterion.


BENZO[B]FLUORANTHENE

An ortho- and peri-fused polycyclic arene that consists of a benzene ring fused with a acephenanthrylene ring.


PELARGONIDIN

An anthocyanidin cation that is flavylium substituted by a hydroxy groups at positions 3, 5, 7 and 4'.


indoles

Any compound containing an indole skeleton.


iron dextran

Please consider adding concept for iron dextran. CAS# 9004-66-4. Thank you.


A member of the class of pyrazolopyrimidine that is pyrazolo[3,4-d]pyrimidin-4-amine bearing additional tert-butyl and 4-chlorophenyl substituents at positions 1 and 3 respectively. It is a potent ATP-competitive inhibitor of the Src family of protein tyrosine kinases.


flavones

A member of the class of flavonoid with a 2-aryl-1-benzopyran-4-one (2-arylchromen-4-one) skeleton and its substituted derivatives.


A member of the class of phenanthrenes that is phenanthrene substituted by a methyl group at position 1.


sodium molybdate (anhydrous)

An inorganic sodium salt having molybdate as the counterion.


eukaryotic 48S preinitiation complex

description: The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC.


multi-eIF complex

description: A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.


name: methionyl-initiator methionine tRNA binding

description: Binding to methionine-initiator methionine tRNA.


histone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells.


CCR4-NOT core complex

description: The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.


central nervous system morphogenesis

description: The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.


protein linear deubiquitination

description: A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein.


name: regulation of dendritic spine morphogenesis

description: Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


regulation of mRNA modification

description: Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


calcium phosphate

A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.


name: ABCF1_HUMAN ATP-binding cassette sub-family F member 1 (sprot)

description: An ATP-binding cassette sub-family F member 1 that is encoded in the genome of human.


DEMA_HUMAN Dematin (sprot)

A dematin that is encoded in the genome of human.


A zinc-alpha-2-glycoprotein that is encoded in the genome of human.


name: PIP_HUMAN Prolactin-inducible protein (sprot)

description: A prolactin-inducible protein that is encoded in the genome of human.


GENTIAN VIOLET

An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.


HOMIDIUM BROMIDE

The organic bromide salt of ethidium.


METHANESULFONIC ACID METHYL ESTER

A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.


cardiac myofibril

description: A cardiac myofibril is a myofibril specific to cardiac muscle cells.


skeletal muscle myofibril

description: A myofibril of a skeletal muscle fiber.


diaphragm development

description: The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.


filtration diaphragm assembly

description: The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.


pentitol metabolic process

description: The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule.


pentose metabolic process

description: The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.


cellular response to azide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus.


posterior lateral line nerve

description: Cranial nerve which enters the brain between cranial nerves VIII and IX; contains afferents and sensory efferents to the posterior lateral line ganglion and middle ganglion. Fibers from the posterior lateral line ganglion innervate the occipital dorsal lateral line and trunk lateral lines.


name: interferon alpha/beta receptor 2 isoform 2 (human)

description: An interferon alpha/beta receptor 2 isoform 2 that is encoded in the genome of human.


CHRAC

description: An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair.


name: DNA polymerase processivity factor activity

description: An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.


name: regulation of circadian sleep/wake cycle

description: Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.


HIKES_HUMAN Protein Hikeshi (sprot)

A protein Hikeshi that is encoded in the genome of human.


name: HSBP1_HUMAN Heat shock factor-binding protein 1 (sprot)

description: A heat shock factor-binding protein 1 that is encoded in the genome of human.


name: CRYAB_HUMAN Alpha-crystallin B chain (sprot)

description: An alpha-crystallin B chain that is encoded in the genome of human.


name: HSPB8_HUMAN Heat shock protein beta-8 (sprot)

description: A heat shock protein beta-8 that is encoded in the genome of human.


name: Glc2Man9GlcNAc2 oligosaccharide glucosidase activity

description: Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H2O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose.


glucosidase II complex

description: A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins.


name: box C/D methylation guide snoRNP complex

description: A ribonucleoprotein complex containing a box C/D type RNA that is capable of ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya.


mitochondrial ribosome

description: A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.


copper chaperone activity

description: Directly binding to and delivering copper ions to a target protein.


name: regulation of cellular response to hypoxia

description: Any process that modulates the frequency, rate or extent of cellular response to hypoxia.


CAT tailing

description: The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control system.


mitochondrial tRNA processing

description: The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion.


An organic anionic group obtained by deprotonation of the phosphate OH group of N(1)-methyladenosine 5'-monophosphate residue.


peptide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.


nuclear pore complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.


name: acetylcholine receptor regulator activity

description: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.


regulation of synaptic activity

description: Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.


regulation of myotube differentiation

description: Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


name: positive regulation of synaptic transmission, cholinergic

description: Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.


name: detection of cold stimulus involved in thermoception

description: The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception.


nuclear pore nuclear basket

description: A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.


maintenance of RNA location

description: Any process in which RNA is maintained in a location and prevented from moving elsewhere.


name: regulation of cholangiocyte apoptotic process

description: Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process.


chromaffin granule membrane

description: The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.


name: guanine nucleotide transmembrane transporter activity

description: Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other.


ADP transmembrane transporter activity

description: Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other.


name: guanine nucleotide transmembrane transport

description: The process in which a guanyl nucleotide is transported across a membrane.


name: DNA-binding protein Ikaros isoform Ik1 (human)

description: A DNA-binding protein Ikaros isoform 1 that is encoded in the genome of human.


ceramide binding

description: Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes.


name: regulation of macrophage differentiation

description: Any process that modulates the frequency, rate or extent of macrophage differentiation.


hair-down neuron

description: The subcutaneous mechanoreceptors that innervate vellus hairs.


sensory neuron of dorsal root ganglion

description: A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord.


dorsal cochlear nucleus

description: The dorsal cochlear nucleus (DCN, also known as the 'tuberculum acousticum'), is a cortex-like structure on the dorso-lateral surface of the brainstem. Along with the ventral cochlear nucleus, it forms the cochlear nucleus, where all auditory nerve fibers from the cochlea form their first synapses. [WP,unvetted].


hippocampal CA1-3 neuron

description: A neuron that has its soma located in CA1-3 of the hippocampus.


name: hippocampal pyramidal neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus.


name: regulation of action potential firing threshold

description: Any process that regulates the potential at which an axon potential is triggered.


apoptosome assembly

description: The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process.


name: intrinsic apoptotic signaling pathway in response to osmotic stress

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.


name: regulation of monoatomic ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.


cation

A monoatomic or polyatomic species having one or more elementary charges of the proton.


divalent metal cation

A metal cation with a valence of two.


name: ATP4A_HUMAN Potassium-transporting ATPase alpha chain 1 (sprot)

description: A potassium-transporting ATPase alpha chain 1 that is encoded in the genome of human.


regulation of protein glycosylation

description: Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


name: regulation of neural crest cell fate specification

description: Any process that modulates the frequency, rate or extent of neural crest cell fate specification.


junctional membrane complex

description: Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).


name: RNA N6-methyladenosine methyltransferase complex

description: A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).


positive regulation of myoblast fusion

description: Any process that activates or increases the frequency, rate or extent of myoblast fusion.


B-1a B cell differentiation

description: The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.


name: negative regulation of stem cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.


pulmonary valve morphogenesis

description: The process in which the structure of the pulmonary valve is generated and organized.


mitotic DNA replication initiation

description: Any DNA replication initiation involved in mitotic cell cycle DNA replication.


name: positive regulation of DNA replication origin binding

description: Any process that activates or increases the frequency, rate or extent of DNA replication origin binding.


alpha DNA polymerase:primase complex

description: A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.


name: transcription antitermination factor activity, DNA binding

description: Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.


name: carbon catabolite repression of transcription from RNA polymerase II promoter by glucose

description: A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.


transcription antitermination

description: A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions.


name: RSH6A_HUMAN Radial spoke head protein 6 homolog A (sprot)

description: A radial spoke head protein 6 homolog A that is encoded in the genome of human.


regulation of neuronal action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


response to superoxide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.


endothelin production

description: The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions.


name: atrioventricular node cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.


cardiac pacemaker cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.


phloem or xylem histogenesis

description: The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana.


ergosterol metabolic process

description: The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light.


radial spoke

description: Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.


radial spoke stalk

description: Protein complex forming the elongated portion of the radial spoke between the base which binds to the A-tubule of each microtubule outer doublet and the neck which connects to the spoke head within the ciliary or flagellum axoneme.


name: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


radial spoke head 2

description: The portion of the radial spoke 2 that is orthogonal to the elongated stalk and which projects towards the central pair of microtubules within the ciliary axoneme.


name: MCM10_HUMAN Protein MCM10 homolog (sprot)

description: A protein MCM10 that is encoded in the genome of human.


name: nuclear origin of replication recognition complex

description: A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.


name: mitotic DNA integrity checkpoint signaling

description: A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.


CoA-synthesizing protein complex

description: A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway.


name: extrinsic component of mitochondrial outer membrane

description: The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


photoreceptor activity

description: The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.


diacylglycerol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


monoacylglycerol metabolic process

description: The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.


name: protein localization to pericentriolar material

description: A process in which a protein is transported to, or maintained in, a location within a pericentriolar material.


endoplasmic reticulum localization

description: Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell.


ubiquinone binding

description: Binding to ubiquinone, a quinone derivative with a tail of isoprene units.


DNA transport

description: The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: nascent polypeptide-associated complex binding

description: Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.


ribosome localization

description: A process in which a ribosome is transported to, and/or maintained in, a specific location.


name: negative regulation of translation in response to stress

description: Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.


establishment of tissue polarity

description: Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.


name: regulation of Rap protein signal transduction

description: Any process that modulates the frequency, rate or extent of Rap protein signal transduction.


EPN1_HUMAN Epsin-1 (sprot)

An epsin-1 that is encoded in the genome of human.


name: EP15R_HUMAN Epidermal growth factor receptor substrate 15-like 1 (sprot)

description: An epidermal growth factor receptor substrate 15-like 1 that is encoded in the genome of human.


insulin binding

description: Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


response to glucagon

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.


response to cAMP

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.


cortical microtubule plus-end

description: The plus-end of a cortical microtubule.


name: thiamine diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.


thiamine transport

description: The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.


thiamine metabolic process

description: The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.


name: positive regulation of NAD(P)H oxidase activity

description: Any process that activates or increases the activity of the enzyme NAD(P)H oxidase.


2-oxoglutarate metabolic process

description: The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.


name: minor groove of adenine-thymine-rich DNA binding

description: Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.


regulation of peptide hormone secretion

description: Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


regulation of growth hormone secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell.


epithelial cell-cell adhesion

description: The attachment of an epithelial cell to another epithelial cell via adhesion molecules.


endochitinase activity

description: Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.


exochitinase activity

description: Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain.


glomerular mesangium development

description: The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus.


OFF retinal ganglion cell

description: A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center.


name: G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

description: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).


regulation of glomerulus development

description: Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


proximal tubule development

description: The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology.


ubiquitin-like protein ligase activity

description: Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.


IkappaB kinase complex

description: A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.


gland morphogenesis

description: The process in which the anatomical structures of a gland are generated and organized.


name: positive regulation of smooth muscle cell migration

description: Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.


name: positive regulation of neuron maturation

description: Any process that activates or increases the frequency, rate or extent of neuron maturation.


name: negative regulation of calcium ion transport into cytosol

description: Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.


name: positive regulation of integrin-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway.


name: negative regulation of integrin-mediated signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway.


cell-cell adhesion mediated by integrin

description: The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.


regulation of DNA biosynthetic process

description: Any process that modulates the frequency, rate or extent of DNA biosynthetic process.


Golgi stack

description: The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.


An organophosphate oxoanion obtained by global deprotonation of the hexaphosphate OH groups of P(1),P(6)-bis(5'-adenosyl)hexaphosphate


adenosine 5'-tetraphosphate(5-)

An organophosphate oxoanion that is the pentaanionic form of adenosine 5'-tetraphosphate.


dipeptide zwitterion

Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3.


name: MIP_CHLTR Peptidyl-prolyl cis-trans isomerase Mip (sprot)


regulation of meiosis I

description: Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.


acetyl-CoA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.


name: positive regulation of hematopoietic stem cell migration

description: Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.


name: negative regulation of cardioblast differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


fat cell apoptotic process

description: Any apoptotic process in a fat cell.


response to interleukin-7

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.


myofibroblast differentiation

description: The process in which an undifferentiated cell acquires the features of a myofibroblast cell.


name: regulation of myofibroblast differentiation

description: Any process that modulates the frequency, rate or extent of myofibroblast differentiation.


response to bleomycin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus.


lung connective tissue development

description: The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.


response to interleukin-13

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


name: chemokine (C-C motif) ligand 11 production

description: The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: leukemia inhibitory factor receptor binding

description: Binding to an leukemia inhibitory factor receptor.


name: maternal process involved in female pregnancy

description: A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.


name: regulation of RNA polymerase II regulatory region sequence-specific DNA binding

description: Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.


spongiotrophoblast differentiation

description: The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell.


A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity.


A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof.


vitamin B6 catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


heat shock protein binding

description: Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.


name: pronephric proximal tubule morphogenesis

description: The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


chelerythrine

A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.


azide

Any nitrogen molecular entity containing the group -N3.


A dinitrophenol having the nitro groups at the 2- and 4-positions.


The (4R,5S)-isomer of dethiobiotin.


gamma-aminobutyric acid reuptake

description: The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


nucleus ambiguus

description: A region of histologically disparate cells located just dorsal to the inferior olivary nucleus in the lateral portion of the upper medulla. It receives upper motor neuron innervation directly via the corticobulbar tract This nucleus gives rise to the efferent motor fibers of the vagus nerve terminating in the laryngeal and pharyngeal muscles, as well as to the efferent motor fibers of the glossopharyngeal nerve (CN IX) terminating in the stylopharyngeus. [WP,unvetted].


GTP 3',8'-cyclase activity

description: Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.


name: cyclic pyranopterin monophosphate synthase activity

description: Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.


cytoplasmic translational elongation

description: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.


potassium ion binding

description: Binding to a potassium ion (K+).


acetylspermidine deacetylase activity

description: Catalysis of the reaction: N(8)-acetylspermidine + H2O = acetate + spermidine.


polyamine deacetylation

description: The modification of acetylpolyamine by the removal of acetyl groups.


spermidine deacetylation

description: The modification of acetylspermadine by the removal of acetyl groups.


regulation of oxygen metabolic process

description: Any process that modulates the frequency, rate or extent of oxygen metabolic process.


CEACAM1a-2L (mouse)

A carcinoembryonic antigen-related cell adhesion molecule 1 sequence variant CEACAM1a (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31809-3. This form contains the two copies of the Ig domain and is the version with longer cytoplasmic tail.


name: protein import into mitochondrial matrix

description: The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.


CAV3_HUMAN Caveolin-3 (sprot)

A caveolin-3 that is encoded in the genome of human.


DYSF_HUMAN Dysferlin (sprot)

A dysferlin that is encoded in the genome of human.


name: TRI72_HUMAN Tripartite motif-containing protein 72 (sprot)

description: A tripartite motif-containing protein 72 that is encoded in the genome of human.


ANXA6_HUMAN Annexin A6 (sprot)

An annexin A6 that is encoded in the genome of human.


name: cell migration involved in heart development

description: The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.


name: MRC1_HUMAN Macrophage mannose receptor 1 (sprot)

description: A macrophage mannose receptor 1 that is encoded in the genome of human.


name: MRC2_HUMAN C-type mannose receptor 2 (sprot)

description: A C-type mannose receptor 2 that is encoded in the genome of human.


name: CLC4K_HUMAN C-type lectin domain family 4 member K (sprot)

description: A C-type lectin domain family 4 member K that is encoded in the genome of human.


calcitroic acid

A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group and the C-23/C-27 unit is replaced by a carboxy group.


name: HG2A_HUMAN HLA class II histocompatibility antigen gamma chain (sprot)

description: An MHC class II histocompatibility antigen gamma chain that is encoded in the genome of human.


name: regulation of action potential firing pattern

description: Any process that regulates the temporal pattern of a sequence of action potentials in a neuron.


name: glycerol-3-phosphate dehydrogenase (FAD) complex

description: An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions.


NADH oxidation

description: A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+.


glycerol-3-phosphate metabolic process

description: The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.


D-ribulose

The D-stereoisomer of ribulose.


regulation of lamellipodium assembly

description: Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.


name: myoblast migration involved in skeletal muscle regeneration

description: The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.