MCIN_HUMAN Multicilin (sprot)

A multicilin that is encoded in the genome of human.


name: H2AY_HUMAN Core histone macro-H2A.1 (sprot)

description: A core histone macro-H2A.1 that is encoded in the genome of human.


name: XRCC1_HUMAN DNA repair protein XRCC1 (sprot)

description: A DNA repair protein XRCC1 that is encoded in the genome of human.


name: SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (sprot)

description: An NAD-dependent protein deacetylase sirtuin-2 that is encoded in the genome of human.


name: TFEB_HUMAN Transcription factor EB (sprot)

description: A transcription factor EB that is encoded in the genome of human.


name: YAP1_HUMAN Transcriptional coactivator YAP1 (sprot)

description: A transcriptional coactivator YAP1 that is encoded in the genome of human.


CASP7_HUMAN Caspase-7 (sprot)

A caspase-7 that is encoded in the genome of human.


name: TYY1_HUMAN Transcriptional repressor protein YY1 (sprot)

description: A transcriptional repressor protein YY1 that is encoded in the genome of human.


name: CSK21_HUMAN Casein kinase II subunit alpha (sprot)

description: A casein kinase II subunit alpha that is encoded in the genome of human.


name: PG029_VACCW IFN signaling evasion protein OPG029 (sprot)


name: STAT2_HUMAN Signal transducer and activator of transcription 2 (sprot)

description: A signal transducer and activator of transcription 2 that is encoded in the genome of human.


name: NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (sprot)

description: A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of human.


name: UBP22_HUMAN Ubiquitin carboxyl-terminal hydrolase 22 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 22 that is encoded in the genome of human.


name: DDX56_HUMAN Probable ATP-dependent RNA helicase DDX56 (sprot)

description: A probable ATP-dependent RNA helicase DDX56 that is encoded in the genome of human.


name: PPARD_HUMAN Peroxisome proliferator-activated receptor delta (sprot)

description: A peroxisome proliferator-activated receptor delta that is encoded in the genome of human.


CUL4A_HUMAN Cullin-4A (sprot)

A cullin-4A that is encoded in the genome of human.


name: DDB1_HUMAN DNA damage-binding protein 1 (sprot)

description: A DNA damage-binding protein 1 that is encoded in the genome of human.


name: ZN212_HUMAN Zinc finger protein 212 (sprot)

description: A zinc finger protein 212 that is encoded in the genome of human.


name: UNG_HUMAN Uracil-DNA glycosylase (sprot)

description: A uracil-DNA glycosylase that is encoded in the genome of human.


name: SMC6_HUMAN Structural maintenance of chromosomes protein 6 (sprot)

description: A structural maintenance of chromosomes protein 6 that is encoded in the genome of human.


name: SMC5_HUMAN Structural maintenance of chromosomes protein 5 (sprot)

description: A structural maintenance of chromosomes protein 5 that is encoded in the genome of human.


name: ARNT_HUMAN Aryl hydrocarbon receptor nuclear translocator (sprot)

description: An aryl hydrocarbon receptor nuclear translocator that is encoded in the genome of human.


name: NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (sprot)

description: A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human.


name: FOXP3_HUMAN Forkhead box protein P3 (sprot)

description: A forkhead box protein P3 that is encoded in the genome of human.


name: nuclear receptor ROR-gamma isoform h2 (human)

description: A nuclear receptor ROR-gamma (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51449-2.


name: RBM47_HUMAN RNA-binding protein 47 (sprot)

description: An RNA-binding protein 47 that is encoded in the genome of human.


name: ABEC1_HUMAN C->U-editing enzyme APOBEC-1 (sprot)

description: A C->U-editing enzyme APOBEC-1 that is encoded in the genome of human.


name: A1CF_HUMAN APOBEC1 complementation factor (sprot)

description: An APOBEC1 complementation factor that is encoded in the genome of human.


VDR_HUMAN Vitamin D3 receptor (sprot)

A vitamin D3 receptor that is encoded in the genome of human.


name: OVOL2_HUMAN Transcription factor Ovo-like 2 (sprot)

description: A transcription factor Ovo-like 2 that is encoded in the genome of human.


name: CEBPA_HUMAN CCAAT/enhancer-binding protein alpha (sprot)

description: A CCAAT/enhancer-binding protein alpha that is encoded in the genome of human.


name: CIDEA_HUMAN Lipid transferase CIDEA (sprot)

description: A lipid transferase CIDEA that is encoded in the genome of human.


name: PRD16_HUMAN Histone-lysine N-methyltransferase PRDM16 (sprot)

description: A histone-lysine N-methyltransferase PRDM16 that is encoded in the genome of human.


name: SMCA4_HUMAN Transcription activator BRG1 (sprot)

description: A transcription activator BRG1 that is encoded in the genome of human.


name: LETM1 domain-containing protein 1 isoform h4 (human)

description: A LETM1 domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6P1Q0-4.


name: GCR_HUMAN Glucocorticoid receptor (sprot)

description: A glucocorticoid receptor that is encoded in the genome of human.


name: ZN764_HUMAN Zinc finger protein 764 (sprot)

description: A zinc finger protein 764 that is encoded in the genome of human.


name: FMR1_HUMAN Fragile X messenger ribonucleoprotein 1 (sprot)

description: A fragile X messenger ribonucleoprotein 1 that is encoded in the genome of human.


name: MTA70_HUMAN N6-adenosine-methyltransferase catalytic subunit (sprot)

description: An N6-adenosine-methyltransferase catalytic subunit that is encoded in the genome of human.


name: MET14_HUMAN N6-adenosine-methyltransferase non-catalytic subunit (sprot)

description: An N6-adenosine-methyltransferase non-catalytic subunit that is encoded in the genome of human.


name: TRI15_HUMAN E3 ubiquitin-protein ligase TRIM15 (sprot)

description: An E3 ubiquitin-protein ligase TRIM15 that is encoded in the genome of human.


name: SKP1_HUMAN S-phase kinase-associated protein 1 (sprot)

description: An S-phase kinase-associated protein 1A that is encoded in the genome of human.


FBX7_HUMAN F-box only protein 7 (sprot)

An F-box only protein 7 that is encoded in the genome of human.


name: SIR7_HUMAN NAD-dependent protein deacetylase sirtuin-7 (sprot)

description: An NAD-dependent protein deacetylase sirtuin-7 that is encoded in the genome of human.


name: SUV92_HUMAN Histone-lysine N-methyltransferase SUV39H2 (sprot)

description: A histone-lysine N-methyltransferase SUV39H2 that is encoded in the genome of human.


name: SUV91_HUMAN Histone-lysine N-methyltransferase SUV39H1 (sprot)

description: A histone-lysine N-methyltransferase SUV39H1 that is encoded in the genome of human.


name: TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase (sprot)

description: A tRNA (guanine-N(7)-)-methyltransferase that is encoded in the genome of human.


name: WDR4_HUMAN tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (sprot)

description: A tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 that is encoded in the genome of human.


name: UBP10_HUMAN Ubiquitin carboxyl-terminal hydrolase 10 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 10 that is encoded in the genome of human.


name: FOXO4_HUMAN Forkhead box protein O4 (sprot)

description: A forkhead box protein O4 that is encoded in the genome of human.


name: JMJD6_HUMAN Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (sprot)

description: A bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 that is encoded in the genome of human.


name: MYC_HUMAN Myc proto-oncogene protein (sprot)

description: A c-myc protein that is encoded in the genome of human.


name: TRI26_HUMAN Tripartite motif-containing protein 26 (sprot)

description: A tripartite motif-containing protein 26 that is encoded in the genome of human.


name: TAF7_HUMAN Transcription initiation factor TFIID subunit 7 (sprot)

description: A transcription initiation factor TFIID subunit 7 that is encoded in the genome of human.


name: UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.


name: UBP38_HUMAN Ubiquitin carboxyl-terminal hydrolase 38 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 38 that is encoded in the genome of human.


name: F-box/WD repeat-containing protein 7 isoform h1 (human)

description: An F-box/WD repeat-containing protein 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969H0-1.


name: SMAD5_HUMAN Mothers against decapentaplegic homolog 5 (sprot)

description: A smad5 that is encoded in the genome of human.


name: SMAD9_HUMAN Mothers against decapentaplegic homolog 9 (sprot)

description: A smad9 that is encoded in the genome of human.


name: TFE3_HUMAN Transcription factor E3 (sprot)

description: A transcription factor E3 that is encoded in the genome of human.


name: BMAL1_HUMAN Basic helix-loop-helix ARNT-like protein 1 (sprot)

description: A basic helix-loop-helix ARNT-like protein 1 that is encoded in the genome of human.


name: KDM4D_HUMAN Lysine-specific demethylase 4D (sprot)

description: A lysine-specific demethylase 4D that is encoded in the genome of human.


name: QKI_HUMAN KH domain-containing RNA-binding protein QKI (sprot)

description: A KH domain-containing RNA-binding protein QKI that is encoded in the genome of human.


name: KAT8_HUMAN Histone acetyltransferase KAT8 (sprot)

description: A histone acetyltransferase KAT8 that is encoded in the genome of human.


name: NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (sprot)

description: A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of human.


NF-kappaB complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.


name: CCNB1_HUMAN G2/mitotic-specific cyclin-B1 (sprot)

description: A G2/mitotic-specific cyclin-B1 that is encoded in the genome of human.


name: UBP51_HUMAN Ubiquitin carboxyl-terminal hydrolase 51 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 51 that is encoded in the genome of human.


name: transcriptional coactivator YAP1 isoform h2 (human)

description: A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-2.


name: WWTR1_HUMAN WW domain-containing transcription regulator protein 1 (sprot)

description: A WW domain-containing transcription regulator protein 1 that is encoded in the genome of human.


name: PAX7_HUMAN Paired box protein Pax-7 (sprot)

description: A paired box protein Pax-7 that is encoded in the genome of human.


name: SNAI1_HUMAN Zinc finger protein SNAI1 (sprot)

description: A zinc finger protein SNAI1 that is encoded in the genome of human.


name: ATF4_HUMAN Cyclic AMP-dependent transcription factor ATF-4 (sprot)

description: A cyclic AMP-dependent transcription factor ATF-4 that is encoded in the genome of human.


name: MSL2_HUMAN E3 ubiquitin-protein ligase MSL2 (sprot)

description: An E3 ubiquitin-protein ligase MSL2 that is encoded in the genome of human.


name: MS3L1_HUMAN MSL complex subunit 3 (sprot)

description: A male-specific lethal 3 that is encoded in the genome of human.


name: MSL1_HUMAN Male-specific lethal 1 homolog (sprot)

description: A male-specific lethal 1 that is encoded in the genome of human.


name: RSSA_HUMAN Small ribosomal subunit protein uS2 (sprot)

description: A eukaryotic-type small ribosomal subunit protein uS2 that is encoded in the genome of human.


name: SMCA5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (sprot)

description: A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 that is encoded in the genome of human.


name: PRP4K_HUMAN Serine/threonine-protein kinase PRP4 homolog (sprot)

description: A serine/threonine-protein kinase PRP4 that is encoded in the genome of human.


brain development

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).


DNA repair

description: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.


name: negative regulation of transcription elongation by RNA polymerase II

description: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


AIM2 inflammasome complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form the AIM2 inflammasome complex.


chromatin remodeling

description: A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.


damaged DNA binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to damaged DNA.


protein homodimerization activity

description: Binding to an identical protein to form a homodimer.


SUMO ligase activity

description: Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.


name: protein localization to site of double-strand break

description: Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.


name: cysteine-type endopeptidase activator activity

description: Binds to and increases the activity of a cysteine-type endopeptidase.


UFM1 ligase activity

description: Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate.


histone H2AXS139 kinase activity

description: Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX.


nuclear membrane disassembly

description: The controlled breakdown of the nuclear membranes, for example during cellular division.


name: protein-arginine omega-N asymmetric methyltransferase activity

description: Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.


histone ubiquitin ligase activity

description: Catalysis of the transfer of ubiquitin to a histone substrate.


chromatin

description: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.


site of DNA damage

description: A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


site of double-strand break

description: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


nuclear envelope

description: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).


intestinal crypt stem cell

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells.


neural cell

description: A cell that is part of the nervous system.


stem cell of epidermis

description: A somatic stem cell that is part of the epidermis.


totipotent stem cell

description: A stem cell from which all cells of the body can form.


erythroid progenitor cell

description: A progenitor cell committed to the erythroid lineage.


name: TP53B_HUMAN TP53-binding protein 1 (sprot)

description: A TP53-binding protein 1 that is encoded in the genome of human.


name: RN168_HUMAN E3 ubiquitin-protein ligase RNF168 (sprot)

description: An E3 ubiquitin-protein ligase RNF168 that is encoded in the genome of human.


name: DGCR8_HUMAN Microprocessor complex subunit DGCR8 (sprot)

description: A microprocessor complex subunit DGCR8 that is encoded in the genome of human.


name: ASF1A_HUMAN Histone chaperone ASF1A (sprot)

description: A histone chaperone ASF1A that is encoded in the genome of human.


name: SPNDC_HUMAN Spindlin interactor and repressor of chromatin-binding protein (sprot)

description: A spindlin interactor and repressor of chromatin-binding protein that is encoded in the genome of human.


name: PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (sprot)

description: A poly [ADP-ribose] polymerase 2 that is encoded in the genome of human.


LMNA_HUMAN Prelamin-A/C (sprot)

A prelamin-A/C that is encoded in the genome of human.


name: ANM1_HUMAN Protein arginine N-methyltransferase 1 (sprot)

description: A protein arginine N-methyltransferase 1 that is encoded in the genome of human.


name: TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (sprot)

description: A DNA topoisomerase 2-binding protein 1 that is encoded in the genome of human.


name: MDC1_HUMAN Mediator of DNA damage checkpoint protein 1 (sprot)

description: A mediator of DNA damage checkpoint protein 1 that is encoded in the genome of human.


name: ATR_HUMAN Serine/threonine-protein kinase ATR (sprot)

description: A serine/threonine-protein kinase ATR that is encoded in the genome of human.


name: RAD9A_HUMAN Cell cycle checkpoint control protein RAD9A (sprot)

description: A cell cycle checkpoint control protein RAD9A that is encoded in the genome of human.


name: HTSF1_HUMAN 17S U2 SnRNP complex component HTATSF1 (sprot)

description: A 17S U2 SnRNP complex component HTATSF1 that is encoded in the genome of human.


Mre11 complex

description: Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.


name: RAD17_HUMAN Cell cycle checkpoint protein RAD17 (sprot)

description: A cell cycle checkpoint protein RAD17 that is encoded in the genome of human.


name: H2A1A_HUMAN Histone H2A type 1-A (sprot)

description: A histone H2A type 1-A that is encoded in the genome of human.


name: MRE11_HUMAN Double-strand break repair protein MRE11 (sprot)

description: A double-strand break repair protein MRE11 that is encoded in the genome of human.


name: GFI1_HUMAN Zinc finger protein Gfi-1 (sprot)

description: A zinc finger protein Gfi-1 that is encoded in the genome of human.


name: CTIP_HUMAN DNA endonuclease RBBP8 (sprot)

description: A DNA endonuclease RBBP8 that is encoded in the genome of human.


name: PIAS1_HUMAN E3 SUMO-protein ligase PIAS1 (sprot)

description: An E3 SUMO-protein ligase PIAS1 that is encoded in the genome of human.


CAMPTOTHECIN

A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).


hydroxyurea

A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.


molecular function regulator activity

description: A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.


fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.


mRNA stabilization

description: Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.


fatty acid synthase complex

description: A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.


name: snRNA transcription by RNA polymerase II

description: The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.


RNA endonuclease activity

description: Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.


A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of GTP; major species present at pH 7.3.


A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of CTP; major species present at pH 7.3.


A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of UTP; major species present at pH 7.3.


name: CDK7_HUMAN Cyclin-dependent kinase 7 (sprot)

description: A cyclin-dependent kinase 7 that is encoded in the genome of human.


regionalization

description: The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.


membrane

description: A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.


hyaluronan synthase activity

description: Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP.


atrioventricular canal development

description: The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.


heart looping

description: The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation.


somitogenesis

description: The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.


fin regeneration

description: The regrowth of fin tissue following its loss or destruction.


blood vessel development

description: The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.


atrioventricular valve morphogenesis

description: The process in which the structure of the atrioventricular valve is generated and organized.


regulation of BMP signaling pathway

description: Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.


embryonic heart tube development

description: The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.


atrioventricular valve development

description: The progression of the atrioventricular valve over time, from its formation to the mature structure.


heart jogging

description: The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.


hyaluronan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.


cell migration in hindbrain

description: The orderly movement of a cell that will reside in the hindbrain.


cell migration involved in gastrulation

description: The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).


mesodermal cell migration

description: The orderly movement of mesodermal cells from one site to another.


dorsal convergence

description: The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.


heart development

description: The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.


actin cytoskeleton

description: The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.


heart morphogenesis

description: The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.


name: regulation of DNA-templated transcription

description: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.


cardiac muscle cell differentiation

description: The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.


retina morphogenesis in camera-type eye

description: The process in which the anatomical structure of the retina is generated and organized.


name: positive regulation of DNA-templated transcription

description: Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.


limb bud formation

description: The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.


optic nerve development

description: The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.


animal organ morphogenesis

description: Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


pectoral fin morphogenesis

description: The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.


cardiac muscle tissue regeneration

description: The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.


pectoral fin development

description: The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.


DNA-templated transcription

description: The synthesis of an RNA transcript from a DNA template.


cardiac chamber morphogenesis

description: The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.


embryonic heart tube morphogenesis

description: The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.


proepicardium development

description: The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.


pericardium morphogenesis

description: The process in which the anatomical structure of the pericardium is generated and organized.


atrial ventricular junction remodeling

description: The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.


embryonic pectoral fin morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.


atrioventricular valve formation

description: The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


Wnt signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state.


lipid droplet organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.


name: negative regulation of protein localization to nucleus

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.


establishment of planar polarity

description: Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.


name: cell migration involved in sprouting angiogenesis

description: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.


blood coagulation

description: The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.


protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


actin cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.


erythrocyte enucleation

description: The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation.


name: negative regulation of catalytic activity

description: Any process that stops or reduces the activity of an enzyme.


name: regulation of phosphatidic acid biosynthetic process

description: Any process that modulates the frequency, rate or extent of phosphatidic acid biosynthetic process.


cell morphogenesis

description: The developmental process in which the size or shape of a cell is generated and organized.


protein folding

description: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.


monoatomic ion transport

description: The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.


name: negative regulation of DNA-templated transcription

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.


nucleotide-excision repair

description: A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).


organelle assembly

description: The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.


chromatin organization

description: The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.


immune response

description: Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.


protein localization to nucleus

description: A process in which a protein transports or maintains the localization of another protein to the nucleus.


name: regulation of cyclic nucleotide-gated ion channel activity

description: Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity.


viral RNA genome replication

description: The replication of a viral RNA genome.


positive regulation of BMP secretion

description: Any process that activates or increases the frequency, rate or extent of BMP secretion.


response to oxidative stress

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


name: late endosome to vacuole transport via multivesicular body sorting pathway

description: The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.


name: nuclear protein quality control by the ubiquitin-proteasome system

description: A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation.


toll-like receptor 5 signaling pathway

description: The series of molecular signals initiated by a ligand binding to toll-like receptor 5.


T-helper 17 type immune response

description: An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22.


description: The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


protein localization to P-body

description: Any process in which a protein is transported to, or maintained at, a P-body.


cellular response to interleukin-17

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.


name: negative regulation of protein kinase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.


tRNA export from nucleus

description: The directed movement of tRNA from the nucleus to the cytoplasm.


tRNA processing

description: The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.


lysosomal protein catabolic process

description: Any cellular protein catabolic process that takes place in a lysosome.


protein export from nucleus

description: The directed movement of a protein from the nucleus into the cytoplasm.


regulation of TORC1 signaling

description: Any process that modulates the frequency, rate or extent of TORC1 signaling.


cellular response to glucose starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.


name: negative regulation of cGAS/STING signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway.


dendrite development

description: The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.


name: negative regulation of double-strand break repair via homologous recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.


name: negative regulation of myoblast differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


vacuolar acidification

description: Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.


name: negative regulation of protein localization to chromatin

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.


name: positive regulation of stem cell population maintenance

description: Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.


name: negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion

description: Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion.


name: organelle localization by membrane tethering

description: The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.


description: The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: termination of RNA polymerase III transcription

description: A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.


name: endosome to plasma membrane protein transport

description: The directed movement of proteins from the endosome to the plasma membrane in transport vesicles.


insulin receptor recycling

description: The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.


protein-containing complex disassembly

description: The disaggregation of a protein-containing macromolecular complex into its constituent components.


sensory perception of pain

description: The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.


endodermal cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.


negative regulation of axon extension

description: Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.


name: negative regulation of cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.


name: response to pheromone triggering conjugation with cellular fusion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.


name: MAP kinase tyrosine/serine/threonine phosphatase activity

description: Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.


name: vascular endothelial growth factor signaling pathway

description: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


serine-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


self proteolysis

description: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.


regulation of protein binding

description: Any process that modulates the frequency, rate or extent of protein binding.


BMP binding

description: Binding to a member of the bone morphogenetic protein (BMP) family.


BMP receptor activity

description: Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.


negative regulation of protein binding

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.


histone serotonyltransferase activity

description: Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+).


ephrin receptor binding

description: Binding to an ephrin receptor.


name: proton transmembrane transporter activity

description: Enables the transfer of a proton from one side of a membrane to the other.


molecular function activator activity

description: A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


positive regulation of protein binding

description: Any process that activates or increases the frequency, rate or extent of protein binding.


cell population proliferation

description: The multiplication or reproduction of cells, resulting in the expansion of a cell population.


GTPase activator activity

description: Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.


cell differentiation

description: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


description: Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.


cytokine activity

description: The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.


coreceptor activity

description: Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.


muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.


Wnt receptor activity

description: Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.


GTPase activity

description: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.


RNA-dependent RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.


T cell activation

description: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


monoatomic ion channel activity

description: Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).


lncRNA binding

description: Binding to a long noncoding RNA (lncRNA).


cell activation

description: A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.


viral transcription

description: The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.


lipid binding

description: Binding to a lipid.


name: mRNA 5'-cap (guanine-N7-)-methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.


viral translation

description: A process by which viral mRNA is translated into viral protein, using the host cellular machinery.


description: Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.


name: double membrane vesicle viral factory assembly

description: A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle.


translation activator activity

description: Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.


name: cytokine production involved in inflammatory response

description: The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.


JUN kinase activity

description: Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.


name: Rho-dependent protein serine/threonine kinase activity

description: Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.


protein kinase binding

description: Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.


virus receptor activity

description: Combining with a virus component and mediating entry of the virus into the cell.


monooxygenase activity

description: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.


microtubule nucleator activity

description: The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly.


protein dimerization activity

description: The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


RNA uridylyltransferase activity

description: Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1).


name: single-stranded DNA endodeoxyribonuclease activity

description: Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.


regulation of autophagosome assembly

description: Any process that modulates the frequency, rate or extent of autophagosome assembly.


interleukin-12 receptor activity

description: Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


keratinocyte activation

description: A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines.


MHC protein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.


extracellular matrix

description: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.


extracellular space

description: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.


apical plasma membrane

description: The region of the plasma membrane located at the apical end of the cell.


blood plasma

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The liquid component of blood, in which erythrocytes are suspended.


cerebral cortex neuron

description: A CNS neuron of the cerebral cortex.


Golgi apparatus

description: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.


mitochondrial outer membrane

description: The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.


cerebral subcortex

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain.


late endosome

description: A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.


erythroblast

description: A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.


cochlear outer hair cell

description: A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea.


synapse

description: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.


mitochondrial cloud

description: A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material.


cytoplasmic vesicle

description: A vesicle found in the cytoplasm of a cell.


osteoclast

description: A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.


endoplasmic reticulum membrane

description: The lipid bilayer surrounding the endoplasmic reticulum.


germ plasm

description: Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.


nuclear membrane

description: Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.


ESC/E(Z) complex

description: A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.


endosome

description: A vacuole to which materials ingested by endocytosis are delivered.


double membrane vesicle viral factory

description: A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae.


lipid droplet

description: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.


fungal-type vacuole membrane

description: The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.


clathrin-coated pit

description: A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.


vacuolar membrane

description: The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.


potassium channel complex

description: An ion channel complex through which potassium ions pass.


voltage-gated potassium channel complex

description: A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.


nucleosome

description: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.


actin filament

description: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.


enterocyte

description: An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen.


BLOC-1 complex

description: A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.


name: RNA polymerase transcription factor SL1 complex

description: A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48.


peritoneal macrophage

description: A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive.


organelle membrane contact site

description: A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.


Bergmann glial cell

description: Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses.


regular ventricular cardiac myocyte

description: Regular cardiac myocyte of a cardiac ventricle.


plasma membrane protein complex

description: Any protein complex that is part of the plasma membrane.


outer dense fiber

description: A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.


myelinating Schwann cell

description: A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons.


natural killer cell

description: A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.


decidua

description: The maternal uterine-derived portion of the placenta.


pancreatic acinar cell

description: A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.


zymogen granule membrane

description: The lipid bilayer surrounding a zymogen granule.


connective tissue cell

description: A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.


egg cell

description: A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.


synaptic membrane

description: A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


ON-bipolar cell

description: A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors.


cortical thymic epithelial cell

description: An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells.


enteric neuron

description: Neuron that is part of the enteric nervous system.


alpha-beta T cell

description: A T cell that expresses an alpha-beta T cell receptor complex.


taste receptor cell

description: A specialized cell involved in gustatory sensory perception.


name: CLC14_HUMAN C-type lectin domain family 14 member A (sprot)

description: A C-type lectin domain family 14 member A that is encoded in the genome of human.


COF1_MOUSE Cofilin-1 (sprot)

A cofilin-1 that is encoded in the genome of mouse.


PLEK2_MOUSE Pleckstrin-2 (sprot)

A pleckstrin-2 that is encoded in the genome of mouse.


name: P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (sprot)

description: A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human.


name: RBP56_HUMAN TATA-binding protein-associated factor 2N (sprot)

description: A TATA-binding protein-associated factor 2N that is encoded in the genome of human.


name: FUS_HUMAN RNA-binding protein FUS (sprot)

description: An RNA-binding protein FUS that is encoded in the genome of human.


name: RB27A_MOUSE Ras-related protein Rab-27A (sprot)

description: A Ras-related protein Rab-27A that is encoded in the genome of mouse.


name: RAB7A_MOUSE Ras-related protein Rab-7a (sprot)

description: A Ras-related protein Rab-7a that is encoded in the genome of mouse.


SAP_HUMAN Prosaposin (sprot)

A prosaposin that is encoded in the genome of human.


GRN_HUMAN Progranulin (sprot)

A progranulin that is encoded in the genome of human.


CFAH_MOUSE Complement factor H (sprot)

A complement factor H that is encoded in the genome of mouse.


name: UPP1_MOUSE Uridine phosphorylase 1 (sprot)

description: A uridine phosphorylase 1 that is encoded in the genome of mouse.


UROM_HUMAN Uromodulin (sprot)

A uromodulin that is encoded in the genome of human.


name: TNFA_HUMAN Tumor necrosis factor (sprot)

description: A tumor necrosis factor that is encoded in the genome of human.


SQSTM_HUMAN Sequestosome-1 (sprot)

A sequestosome-1 that is encoded in the genome of human.


name: MLP3B_HUMAN Microtubule-associated proteins 1A/1B light chain 3B (sprot)

description: A microtubule-associated proteins 1A/1B light chain 3B that is encoded in the genome of human.


USH2A_MOUSE Usherin (sprot)

An usherin that is encoded in the genome of mouse.


name: PAIP1_HUMAN Polyadenylate-binding protein-interacting protein 1 (sprot)

description: A polyadenylate-binding protein-interacting protein 1 that is encoded in the genome of human.


name: FOXO1_MOUSE Forkhead box protein O1 (sprot)

description: A forkhead box protein O1 that is encoded in the genome of mouse.


name: T3JAM_HUMAN TRAF3-interacting JNK-activating modulator (sprot)

description: A TRAF3-interacting JNK-activating modulator that is encoded in the genome of human.


name: BRCA2_MOUSE Breast cancer type 2 susceptibility protein homolog (sprot)

description: A breast cancer type 2 susceptibility protein that is encoded in the genome of mouse.


name: PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (sprot)

description: A peroxisome proliferator-activated receptor alpha that is encoded in the genome of human.


name: SF3B1_MOUSE Splicing factor 3B subunit 1 (sprot)

description: A splicing factor 3B subunit 1 that is encoded in the genome of mouse.


name: STK33_HUMAN Serine/threonine-protein kinase 33 (sprot)

description: A serine/threonine-protein kinase 33 that is encoded in the genome of human.


name: TTC36_HUMAN Tetratricopeptide repeat protein 36 (sprot)

description: A tetratricopeptide repeat protein 36 that is encoded in the genome of human.


name: ILF3_HUMAN Interleukin enhancer-binding factor 3 (sprot)

description: An interleukin enhancer-binding factor 3 that is encoded in the genome of human.


name: E3 ubiquitin-protein ligase TRIM47 isoform h1 (human)

description: An E3 ubiquitin-protein ligase TRIM47 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96LD4-1.


name: MICA2_HUMAN [F-actin]-monooxygenase MICAL2 (sprot)

description: An [F-actin]-monooxygenase MICAL2 that is encoded in the genome of human.


name: TPPP_HUMAN Tubulin polymerization-promoting protein (sprot)

description: A tubulin polymerization-promoting protein that is encoded in the genome of human.


name: UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 15 that is encoded in the genome of human.


name: RNF26_HUMAN E3 ubiquitin-protein ligase RNF26 (sprot)

description: An E3 ubiquitin-protein ligase RNF26 that is encoded in the genome of human.


name: ERCC1_HUMAN DNA excision repair protein ERCC-1 (sprot)

description: A DNA excision repair protein ERCC-1 that is encoded in the genome of human.


name: DNA repair endonuclease XPF isoform h2 (human)

description: A DNA repair endonuclease XPF (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92889-2.


choline kinase alpha isoform h1 (human)

A choline kinase alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35790-1.


PLIN3_HUMAN Perilipin-3 (sprot)

A perilipin-3 that is encoded in the genome of human.


PLIN2_HUMAN Perilipin-2 (sprot)

A perilipin-2 that is encoded in the genome of human.


name: HDAC1_HUMAN Histone deacetylase 1 (sprot)

description: A histone deacetylase 1 that is encoded in the genome of human.


name: ZFY26_HUMAN Zinc finger FYVE domain-containing protein 26 (sprot)

description: A zinc finger FYVE domain-containing protein 26 that is encoded in the genome of human.


SPTCS_HUMAN Spatacsin (sprot)

A spatacsin that is encoded in the genome of human.


CUL3_MOUSE Cullin-3 (sprot)

A cullin-3 that is encoded in the genome of mouse.


name: IL12B_HUMAN Interleukin-12 subunit beta (sprot)

description: An interleukin-12 subunit beta that is encoded in the genome of human.


name: IL12A_HUMAN Interleukin-12 subunit alpha (sprot)

description: An interleukin-12 subunit alpha that is encoded in the genome of human.


name: YPEL4_MOUSE Protein yippee-like 4 (sprot)

description: A protein yippee-like 4 that is encoded in the genome of mouse.


name: MAP1S_HUMAN Microtubule-associated protein 1S (sprot)

description: A microtubule-associated protein 1S that is encoded in the genome of human.


name: BUB3_HUMAN Mitotic checkpoint protein BUB3 (sprot)

description: A mitotic checkpoint protein BUB3 that is encoded in the genome of human.


name: WAPL_HUMAN Wings apart-like protein homolog (sprot)

description: A wings apart-like protein that is encoded in the genome of human.


name: histone-lysine N-methyltransferase EZH2 isoform ENX-1A (mouse)

description: A histone-lysine N-methyltransferase EZH2 isoform 1 that is encoded in the genome of mouse.


name: RICTR_HUMAN Rapamycin-insensitive companion of mTOR (sprot)

description: A rapamycin-insensitive companion of mTOR that is encoded in the genome of human.


name: WDR59_HUMAN GATOR2 complex protein WDR59 (sprot)

description: A GATOR2 complex protein WDR59 that is encoded in the genome of human.


TSN9_HUMAN Tetraspanin-9 (sprot)

A tetraspanin-9 that is encoded in the genome of human.


name: RPN1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (sprot)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 that is encoded in the genome of human.


name: TM258_HUMAN Transmembrane protein 258 (sprot)

description: A transmembrane protein 258 that is encoded in the genome of human.


name: ELMO1_MOUSE Engulfment and cell motility protein 1 (sprot)

description: An engulfment and cell motility protein 1 that is encoded in the genome of mouse.


TENS3_MOUSE Tensin-3 (sprot)

A tensin-3 that is encoded in the genome of mouse.


INSR_MOUSE Insulin receptor (sprot)

An insulin receptor that is encoded in the genome of mouse.


NDC1_HUMAN Nucleoporin NDC1 (sprot)

A nucleoporin NDC1 that is encoded in the genome of human.


AAAS_HUMAN Aladin (sprot)

An aladin that is encoded in the genome of human.


name: TMM18_MOUSE Transmembrane protein 18 (sprot)

description: A transmembrane protein 18 that is encoded in the genome of mouse.


name: T132A_MOUSE Transmembrane protein 132A (sprot)

description: A transmembrane protein 132A that is encoded in the genome of mouse.


WNT5A_MOUSE Protein Wnt-5a (sprot)

A protein Wnt-5a that is encoded in the genome of mouse.


WNT3A_MOUSE Protein Wnt-3a (sprot)

A protein Wnt-3a that is encoded in the genome of mouse.


name: TIFAB_HUMAN TRAF-interacting protein with FHA domain-containing protein B (sprot)

description: A TRAF-interacting protein with FHA domain-containing protein B that is encoded in the genome of human.


name: TMED2_HUMAN Transmembrane emp24 domain-containing protein 2 (sprot)

description: A transmembrane emp24 domain-containing protein 2 that is encoded in the genome of human.


CD59_HUMAN CD59 glycoprotein (sprot)

A CD59 glycoprotein that is encoded in the genome of human.


name: AGR2_HUMAN Anterior gradient protein 2 homolog (sprot)

description: An anterior gradient protein 2 that is encoded in the genome of human.


name: LYPD3_HUMAN Ly6/PLAUR domain-containing protein 3 (sprot)

description: An Ly6/PLAUR domain-containing protein 3 that is encoded in the genome of human.


name: TERB2_MOUSE Telomere repeats-binding bouquet formation protein 2 (sprot)

description: A telomere repeats-binding bouquet formation protein 2 that is encoded in the genome of mouse.


name: TERB2_HUMAN Telomere repeats-binding bouquet formation protein 2 (sprot)

description: A telomere repeats-binding bouquet formation protein 2 that is encoded in the genome of human.


name: MAJIN_HUMAN Membrane-anchored junction protein (sprot)

description: A membrane-anchored junction protein that is encoded in the genome of human.


name: TERB1_HUMAN Telomere repeats-binding bouquet formation protein 1 (sprot)

description: A telomere repeats-binding bouquet formation protein 1 that is encoded in the genome of human.


name: CDK2_MOUSE Cyclin-dependent kinase 2 (sprot)

description: A cyclin-dependent kinase 2 that is encoded in the genome of mouse.


name: TTI1_HUMAN TELO2-interacting protein 1 homolog (sprot)

description: A TELO2-interacting protein 1 homolog that is encoded in the genome of human.


name: TELO2_HUMAN Telomere length regulation protein TEL2 homolog (sprot)

description: A telomere length regulation protein TEL2 that is encoded in the genome of human.


TSN18_HUMAN Tetraspanin-18 (sprot)

A tetraspanin-18 that is encoded in the genome of human.


name: GRIA4_MOUSE Glutamate receptor 4 (sprot)

description: A glutamate receptor 4 that is encoded in the genome of mouse.


name: WDR5_HUMAN WD repeat-containing protein 5 (sprot)

description: A WD repeat-containing protein 5 that is encoded in the genome of human.


HCFC2_HUMAN Host cell factor 2 (sprot)

A host cell factor 2 that is encoded in the genome of human.


name: SET1A_HUMAN Histone-lysine N-methyltransferase SETD1A (sprot)

description: A histone-lysine N-methyltransferase SETD1A that is encoded in the genome of human.


name: RBBP5_HUMAN Retinoblastoma-binding protein 5 (sprot)

description: A retinoblastoma-binding protein 5 that is encoded in the genome of human.


name: KDM1A_HUMAN Lysine-specific histone demethylase 1A (sprot)

description: A lysine-specific histone demethylase 1A that is encoded in the genome of human.


name: KDM8_MOUSE Bifunctional peptidase and arginyl-hydroxylase JMJD5 (sprot)

description: A bifunctional peptidase and arginyl-hydroxylase JMJD5 that is encoded in the genome of mouse.


name: RBM14_MOUSE RNA-binding protein 14 (sprot)

description: An RNA-binding protein 14 that is encoded in the genome of mouse.


name: BRD3_HUMAN Bromodomain-containing protein 3 (sprot)

description: A bromodomain-containing protein 3 that is encoded in the genome of human.


name: NEGR1_HUMAN Neuronal growth regulator 1 (sprot)

description: A neuronal growth regulator 1 that is encoded in the genome of human.


name: SDS3_MOUSE Sin3 histone deacetylase corepressor complex component SDS3 (sprot)

description: A Sin3 histone deacetylase corepressor complex component SDS3 that is encoded in the genome of mouse.


name: CSKP_MOUSE Peripheral plasma membrane protein CASK (sprot)

description: A peripheral plasma membrane protein CASK that is encoded in the genome of mouse.


name: STAT3_MOUSE Signal transducer and activator of transcription 3 (sprot)

description: A signal transducer and activator of transcription 3 that is encoded in the genome of mouse.


name: NMDE2_MOUSE Glutamate receptor ionotropic, NMDA 2B (sprot)

description: A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of mouse.


name: CDK5_MOUSE Cyclin-dependent kinase 5 (sprot)

description: A cyclin-dependent kinase 5 that is encoded in the genome of mouse.


name: NEK2_MOUSE Serine/threonine-protein kinase Nek2 (sprot)

description: A serine/threonine-protein kinase Nek2 that is encoded in the genome of mouse.


FZD8_MOUSE Frizzled-8 (sprot)

A frizzled-8 that is encoded in the genome of mouse.


WNT1_MOUSE Proto-oncogene Wnt-1 (sprot)

A proto-oncogene Wnt-1 that is encoded in the genome of mouse.


name: DVL1_MOUSE Segment polarity protein dishevelled homolog DVL-1 (sprot)

description: A segment polarity protein dishevelled homolog DVL-1 that is encoded in the genome of mouse.


PEPL_MOUSE Periplakin (sprot)

A periplakin that is encoded in the genome of mouse.


name: KCJ10_MOUSE ATP-sensitive inward rectifier potassium channel 10 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 10 that is encoded in the genome of mouse.


name: CD79B_MOUSE B-cell antigen receptor complex-associated protein beta chain (sprot)

description: A B-cell antigen receptor complex-associated protein beta chain that is encoded in the genome of mouse.


name: KSYK_MOUSE Tyrosine-protein kinase SYK (sprot)

description: A tyrosine-protein kinase SYK that is encoded in the genome of mouse.


name: CD5R1_MOUSE Cyclin-dependent kinase 5 activator 1 (sprot)

description: A cyclin-dependent kinase 5 activator 1 that is encoded in the genome of mouse.


name: CAN1_MOUSE Calpain-1 catalytic subunit (sprot)

description: A calpain-1 catalytic subunit that is encoded in the genome of mouse.


name: P53_MOUSE Cellular tumor antigen p53 (sprot)

description: A cellular tumor antigen p53 that is encoded in the genome of mouse.


name: PURA_MOUSE Transcriptional activator protein Pur-alpha (sprot)

description: A transcriptional activator protein Pur-alpha that is encoded in the genome of mouse.


name: NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4 (sprot)

description: An E3 ubiquitin-protein ligase NEDD4 that is encoded in the genome of mouse.


name: SOX2_MOUSE Transcription factor SOX-2 (sprot)

description: A transcription factor SOX-2 that is encoded in the genome of mouse.


name: EP300_MOUSE Histone acetyltransferase p300 (sprot)

description: A histone acetyltransferase p300 that is encoded in the genome of mouse.


name: EPMIP_MOUSE EPM2A-interacting protein 1 (sprot)

description: An EPM2A-interacting protein 1 that is encoded in the genome of mouse.


name: TRAIP_MOUSE E3 ubiquitin-protein ligase TRAIP (sprot)

description: An E3 ubiquitin-protein ligase TRAIP that is encoded in the genome of mouse.


name: ABL1_MOUSE Tyrosine-protein kinase ABL1 (sprot)

description: A tyrosine-protein kinase ABL1 that is encoded in the genome of mouse.


CTNA1_MOUSE Catenin alpha-1 (sprot)

A catenin alpha-1 that is encoded in the genome of mouse.


name: FNBP1_MOUSE Formin-binding protein 1 (sprot)

description: A formin-binding protein 1 that is encoded in the genome of mouse.


name: MLIP_MOUSE Muscular LMNA-interacting protein (sprot)

description: A muscular LMNA-interacting protein that is encoded in the genome of mouse.


name: LDB1_MOUSE LIM domain-binding protein 1 (sprot)

description: A LIM domain-binding protein 1 that is encoded in the genome of mouse.


name: RNF12_MOUSE E3 ubiquitin-protein ligase RLIM (sprot)

description: An E3 ubiquitin-protein ligase RLIM that is encoded in the genome of mouse.


name: regulator of G-protein signaling 9 isoform 1 (mouse)

description: A regulator of G-protein signaling 9 isoform 3 that is encoded in the genome of mouse.


name: guanine nucleotide-binding protein subunit beta-5 isoform 1 (mouse)

description: A guanine nucleotide-binding protein subunit beta-5 isoform 1 that is encoded in the genome of mouse.


name: R7BP_MOUSE Regulator of G-protein signaling 7-binding protein (sprot)

description: A regulator of G-protein signaling 7-binding protein that is encoded in the genome of mouse.


name: ERCC1_MOUSE DNA excision repair protein ERCC-1 (sprot)

description: A DNA excision repair protein ERCC-1 that is encoded in the genome of mouse.


name: TAF7_MOUSE Transcription initiation factor TFIID subunit 7 (sprot)

description: A transcription initiation factor TFIID subunit 7 that is encoded in the genome of mouse.


name: TAF7L_MOUSE Transcription initiation factor TFIID subunit 7-like (sprot)

description: A transcription initiation factor TFIID subunit 7-like that is encoded in the genome of mouse.


name: TAF1C_MOUSE TATA box-binding protein-associated factor RNA polymerase I subunit C (sprot)

description: A TATA box-binding protein-associated factor RNA polymerase I subunit C that is encoded in the genome of mouse.


name: PIAS4_MOUSE E3 SUMO-protein ligase PIAS4 (sprot)

description: An E3 SUMO-protein ligase PIAS4 that is encoded in the genome of mouse.


name: PIAS1_MOUSE E3 SUMO-protein ligase PIAS1 (sprot)

description: An E3 SUMO-protein ligase PIAS1 that is encoded in the genome of mouse.


GPBP1_MOUSE Vasculin (sprot)

A vasculin that is encoded in the genome of mouse.


name: ZNF76_MOUSE Zinc finger protein 76 (sprot)

description: A zinc finger protein 76 that is encoded in the genome of mouse.


name: TAF6_MOUSE Transcription initiation factor TFIID subunit 6 (sprot)

description: A transcription initiation factor TFIID subunit 6 that is encoded in the genome of mouse.


name: PIAS2_MOUSE E3 SUMO-protein ligase PIAS2 (sprot)

description: An E3 SUMO-protein ligase PIAS2 that is encoded in the genome of mouse.


name: TAF1B_MOUSE TATA box-binding protein-associated factor RNA polymerase I subunit B (sprot)

description: A TATA box-binding protein-associated factor RNA polymerase I subunit B that is encoded in the genome of mouse.


name: TAF1A_MOUSE TATA box-binding protein-associated factor RNA polymerase I subunit A (sprot)

description: A TATA box-binding protein-associated factor RNA polymerase I subunit A that is encoded in the genome of mouse.


name: NDF2_MOUSE Neurogenic differentiation factor 2 (sprot)

description: A neurogenic differentiation factor 2 that is encoded in the genome of mouse.


name: ID2_MOUSE DNA-binding protein inhibitor ID-2 (sprot)

description: A DNA-binding protein inhibitor ID-2 that is encoded in the genome of mouse.


name: ID1_MOUSE DNA-binding protein inhibitor ID-1 (sprot)

description: A DNA-binding protein inhibitor ID-1 that is encoded in the genome of mouse.


name: HAND2_MOUSE Heart- and neural crest derivatives-expressed protein 2 (sprot)

description: A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of mouse.


name: VGLL1_MOUSE Transcription cofactor vestigial-like protein 1 (sprot)

description: A transcription cofactor vestigial-like protein 1 that is encoded in the genome of mouse.


name: VGLL3_MOUSE Transcription cofactor vestigial-like protein 3 (sprot)

description: A transcription cofactor vestigial-like protein 3 that is encoded in the genome of mouse.


name: VGLL2_MOUSE Transcription cofactor vestigial-like protein 2 (sprot)

description: A transcription cofactor vestigial-like protein 2 that is encoded in the genome of mouse.


name: YAP1_MOUSE Transcriptional coactivator YAP1 (sprot)

description: A transcriptional coactivator YAP1 that is encoded in the genome of mouse.


name: DRP2_MOUSE Dystrophin-related protein 2 (sprot)

description: A dystrophin-related protein 2 that is encoded in the genome of mouse.


name: LAMA1_MOUSE Laminin subunit alpha-1 (sprot)

description: A laminin subunit alpha-1 that is encoded in the genome of mouse.


name: SLIT2_MOUSE Slit homolog 2 protein (sprot)

description: A slit homolog 2 protein that is encoded in the genome of mouse.


DAG1_MOUSE Dystroglycan 1 (sprot)

A dystroglycan 1 that is encoded in the genome of mouse.


name: NCOR2_MOUSE Nuclear receptor corepressor 2 (sprot)

description: A nuclear receptor corepressor 2 that is encoded in the genome of mouse.


name: RXRA_MOUSE Retinoic acid receptor RXR-alpha (sprot)

description: A retinoic acid receptor RXR-alpha that is encoded in the genome of mouse.


name: NCOR1_MOUSE Nuclear receptor corepressor 1 (sprot)

description: A nuclear receptor corepressor 1 that is encoded in the genome of mouse.


name: NCOA2_MOUSE Nuclear receptor coactivator 2 (sprot)

description: A nuclear receptor coactivator 2 that is encoded in the genome of mouse.


name: NRIP1_MOUSE Nuclear receptor-interacting protein 1 (sprot)

description: A nuclear receptor-interacting protein 1 that is encoded in the genome of mouse.


name: MED1_MOUSE Mediator of RNA polymerase II transcription subunit 1 (sprot)

description: A mediator of RNA polymerase II transcription subunit 1 that is encoded in the genome of mouse.


name: NCOA1_MOUSE Nuclear receptor coactivator 1 (sprot)

description: A nuclear receptor coactivator 1 that is encoded in the genome of mouse.


name: NCOA3_MOUSE Nuclear receptor coactivator 3 (sprot)

description: A nuclear receptor coactivator 3 that is encoded in the genome of mouse.


name: MK14_MOUSE Mitogen-activated protein kinase 14 (sprot)

description: A mitogen-activated protein kinase 14 that is encoded in the genome of mouse.


name: MK01_MOUSE Mitogen-activated protein kinase 1 (sprot)

description: A mitogen-activated protein kinase 1 that is encoded in the genome of mouse.


name: TLE4_MOUSE Transducin-like enhancer protein 4 (sprot)

description: A transducin-like enhancer protein 4 that is encoded in the genome of mouse.


TLE5_MOUSE TLE family member 5 (sprot)

A TLE family member 5 that is encoded in the genome of mouse.


name: DEN1A_MOUSE DENN domain-containing protein 1A (sprot)

description: A DENN domain-containing protein 1A that is encoded in the genome of mouse.


name: OXSR1_MOUSE Serine/threonine-protein kinase OSR1 (sprot)

description: A serine/threonine-protein kinase OSR1 that is encoded in the genome of mouse.


name: LMBL2_MOUSE Lethal(3)malignant brain tumor-like protein 2 (sprot)

description: A lethal(3)malignant brain tumor-like protein 2 that is encoded in the genome of mouse.


name: SOX17_MOUSE Transcription factor SOX-17 (sprot)

description: A transcription factor SOX-17 that is encoded in the genome of mouse.


name: SRY_MOUSE Sex-determining region Y protein (sprot)

description: A protein that is a translation product of the Sry gene in mouse.


name: SOX14_MOUSE Transcription factor SOX-14 (sprot)

description: A transcription factor SOX-14 that is encoded in the genome of mouse.


name: SOX4_MOUSE Transcription factor SOX-4 (sprot)

description: A transcription factor SOX-4 that is encoded in the genome of mouse.


name: SOX15_MOUSE Transcription factor SOX-15 (sprot)

description: A protein SOX-15 that is encoded in the genome of mouse.


name: CDX2_MOUSE Homeobox protein CDX-2 (sprot)

description: A homeobox protein CDX-2 that is encoded in the genome of mouse.


name: SOX9_MOUSE Transcription factor SOX-9 (sprot)

description: A transcription factor SOX-9 that is encoded in the genome of mouse.


name: SOX5_MOUSE Transcription factor SOX-5 (sprot)

description: A transcription factor SOX-5 that is encoded in the genome of mouse.


name: SOX8_MOUSE Transcription factor SOX-8 (sprot)

description: A transcription factor SOX-8 that is encoded in the genome of mouse.


COLI_MOUSE Pro-opiomelanocortin (sprot)

A pro-opiomelanocortin that is encoded in the genome of mouse.


SCG3_MOUSE Secretogranin-3 (sprot)

A secretogranin-3 that is encoded in the genome of mouse.


name: SRTD2_MOUSE SERTA domain-containing protein 2 (sprot)

description: A SERTA domain-containing protein 2 that is encoded in the genome of mouse.


name: E2F2_MOUSE Transcription factor E2F2 (sprot)

description: A transcription factor E2F2 that is encoded in the genome of mouse.


name: E2F3_MOUSE Transcription factor E2F3 (sprot)

description: A transcription factor E2F3 that is encoded in the genome of mouse.


name: E2F1_MOUSE Transcription factor E2F1 (sprot)

description: A transcription factor E2F1 that is encoded in the genome of mouse.


name: SRTD1_MOUSE SERTA domain-containing protein 1 (sprot)

description: A SERTA domain-containing protein 1 that is encoded in the genome of mouse.


name: E2F5_MOUSE Transcription factor E2F5 (sprot)

description: A transcription factor E2F5 that is encoded in the genome of mouse.


name: E2F4_MOUSE Transcription factor E2F4 (sprot)

description: A transcription factor E2F4 that is encoded in the genome of mouse.


name: MAGD1_MOUSE Melanoma-associated antigen D1 (sprot)

description: A melanoma-associated antigen D1 that is encoded in the genome of mouse.


NECD_MOUSE Necdin (sprot)

A necdin that is encoded in the genome of mouse.


name: TFDP1_MOUSE Transcription factor Dp-1 (sprot)

description: A transcription factor Dp-1 that is encoded in the genome of mouse.


MAGL2_MOUSE MAGE-like protein 2 (sprot)

A MAGE-like protein 2 that is encoded in the genome of mouse.


name: NSE3_MOUSE Non-structural maintenance of chromosomes element 3 homolog (sprot)

description: A protein that is a translation product of the Nsmce3 gene in mouse.


name: CTHR1_MOUSE Collagen triple helix repeat-containing protein 1 (sprot)

description: A collagen triple helix repeat-containing protein 1 that is encoded in the genome of mouse.


name: K2C7_MOUSE Keratin, type II cytoskeletal 7 (sprot)

description: A keratin, type II cytoskeletal 7 that is encoded in the genome of mouse.


name: NF2IP_MOUSE NFATC2-interacting protein (sprot)

description: An NFATC2-interacting protein that is encoded in the genome of mouse.


name: MYOD1_MOUSE Myoblast determination protein 1 (sprot)

description: A myoblast determination protein 1 that is encoded in the genome of mouse.


name: HDAC3_MOUSE Histone deacetylase 3 (sprot)

description: A histone deacetylase 3 that is encoded in the genome of mouse.


DFA31_MOUSE Alpha-defensin 31 (sprot)

A defensin-related cryptdin-related sequence 7 that is encoded in the genome of mouse.


name: PHLP_MOUSE Phosducin-like protein (sprot)

description: A phosducin-like protein that is encoded in the genome of mouse.


name: LY6K_MOUSE Lymphocyte antigen 6K (sprot)

description: A protein that is a translation product of the Ly6k gene in mouse.


name: SKP2_MOUSE S-phase kinase-associated protein 2 (sprot)

description: An S-phase kinase-associated protein 2 that is encoded in the genome of mouse.


name: CAC1A_MOUSE Voltage-dependent P/Q-type calcium channel subunit alpha-1A (sprot)

description: A voltage-dependent P/Q-type calcium channel subunit alpha-1A that is encoded in the genome of mouse.


name: REM1_MOUSE GTP-binding protein REM 1 (sprot)

description: A GTP-binding protein REM 1 that is encoded in the genome of mouse.


name: CAC1B_MOUSE Voltage-dependent N-type calcium channel subunit alpha-1B (sprot)

description: A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of mouse.


name: Q9D828_MOUSE PB1 domain-containing protein (trembl)

description: A Tfg gene translation product (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9D828.


name: UTY_MOUSE Histone demethylase UTY (sprot)

description: A protein that is a translation product of the Uty gene in mouse.


SALL4_MOUSE Sal-like protein 4 (sprot)

A Sal-like protein 4 that is encoded in the genome of mouse.


name: NKX25_MOUSE Homeobox protein Nkx-2.5 (sprot)

description: A homeobox protein Nkx-2.5 that is encoded in the genome of mouse.


name: HIPK2_MOUSE Homeodomain-interacting protein kinase 2 (sprot)

description: A homeodomain-interacting protein kinase 2 that is encoded in the genome of mouse.


TSC1_MOUSE Hamartin (sprot)

A hamartin that is encoded in the genome of mouse.


name: GCR_MOUSE Glucocorticoid receptor (sprot)

description: A glucocorticoid receptor that is encoded in the genome of mouse.


name: KCAB1_MOUSE Voltage-gated potassium channel subunit beta-1 (sprot)

description: A voltage-gated potassium channel subunit beta-1 that is encoded in the genome of mouse.


name: KCNE2_MOUSE Potassium voltage-gated channel subfamily E member 2 (sprot)

description: A potassium voltage-gated channel subfamily E member 2 that is encoded in the genome of mouse.


name: TDRD7_MOUSE Tudor domain-containing protein 7 (sprot)

description: A tudor domain-containing protein 7 that is encoded in the genome of mouse.


name: RANB9_MOUSE Ran-binding protein 9 (sprot)

description: A Ran-binding protein 9 that is encoded in the genome of mouse.


name: GATA3_MOUSE Trans-acting T-cell-specific transcription factor GATA-3 (sprot)

description: A trans-acting T-cell-specific transcription factor GATA-3 that is encoded in the genome of mouse.


AQP5_MOUSE Aquaporin-5 (sprot)

An aquaporin-5 that is encoded in the genome of mouse.


name: CIB2_MOUSE Calcium and integrin-binding family member 2 (sprot)

description: A calcium and integrin-binding family member 2 that is encoded in the genome of mouse.


name: TIAM1_MOUSE Rho guanine nucleotide exchange factor TIAM1 (sprot)

description: A Rho guanine nucleotide exchange factor TIAM1 that is encoded in the genome of mouse.


name: EPHA5_MOUSE Ephrin type-A receptor 5 (sprot)

description: An ephrin type-A receptor 5 that is encoded in the genome of mouse.


EFNB1_MOUSE Ephrin-B1 (sprot)

An ephrin-B1 that is encoded in the genome of mouse.


name: ZHX2_MOUSE Zinc fingers and homeoboxes protein 2 (sprot)

description: A zinc fingers and homeoboxes protein 2 that is encoded in the genome of mouse.


EFNA2_MOUSE Ephrin-A2 (sprot)

An ephrin-A2 that is encoded in the genome of mouse.


name: ADIP_MOUSE Afadin- and alpha-actinin-binding protein (sprot)

description: An afadin- and alpha-actinin-binding protein that is encoded in the genome of mouse.


name: EGFR_MOUSE Epidermal growth factor receptor (sprot)

description: An epidermal growth factor receptor that is encoded in the genome of mouse.


EDN1_MOUSE Endothelin-1 (sprot)

An endothelin-1 that is encoded in the genome of mouse.


name: EYA1_MOUSE Eyes absent homolog 1 (sprot)

description: An eyes absent homolog 1 that is encoded in the genome of mouse.


name: RAB15_MOUSE Ras-related protein Rab-15 (sprot)

description: A Ras-related protein Rab-15 that is encoded in the genome of mouse.


name: ROM1_MOUSE Rod outer segment membrane protein 1 (sprot)

description: A rod outer segment membrane protein 1 that is encoded in the genome of mouse.