name: Colorectal Neuroendocrine Tumor Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of a colorectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system.


name: Other reactive arthropathies, multiple sites

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Evidence of other reactive arthropathies in multiple sites not specified elsewhere.


name: Parathyroid Carcinoma Clinical TNM Finding v8

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A clinical finding about one or more characteristics of parathyroid carcinoma, following the rules of the TNM AJCC v8 classification system.


Oral Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips.


Chemical conjunctivitis

description: Inflammation of the conjunctiva in a newborn due to chemical irritation which was acquired postnatally from iatrogenic causes.


name: Gastric Cancer Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of gastric cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for gastric cancer. (from AJCC 7th Ed.)


Pancreatic Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the pancreas. The Ki-67 index is higher than 20%.


Cutaneous Melanoma cNX TNM Finding v8

description: Cutaneous melanoma in which the regional lymph nodes are not assessed (e.g., sentinel lymph node biopsy is not performed, regional lymph nodes were previously removed for another reason). Exception: pathological N category is not required for T1 melanomas, use cN. Presence of in-transit, satellite, and/or microsatellite metastases: No.  (from AJCC 8th Ed.)


name: Rheumatoid Polyneuropathy with Rheumatoid Arthritis of Unspecified Shoulder

description: Evidence of rheumatoid polyneuropathy with rheumatoid arthritis of unspecified shoulder.


Polygenic Obesity

description: Obesity associated with variations in multiple genes.


name: Grade 3 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Biliary Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Chief Complaint Caused by Trauma

description: An indication that the chief complaint was caused by a traumatic event.


name: Malignant melanoma of right upper eyelid, including canthus

description: Evidence of a malignant melanoma of the right upper eyelid including the canthus.


Port Site Infection

description: An infection at an anatomic location used for vascular access.


Cervical Cancer pN0(i+) TNM Finding v8

description: Cervical cancer with isolated tumor cells in regional lymph node(s) no greater than 0.2 mm. (from AJCC 8th Ed.)


name: Atherosclerosis of Non-Autologous Biological Bypass Graft(s) of the Extremities with Intermittent Claudication, Left Leg

description: Evidence of atherosclerosis of non-autologous biological bypass graft(s) of the extremities with intermittent claudication in the left leg.


Sunstroke

description: A reaction to prolonged exposure to high temperatures that can result in a failure of the body's temperature control system. It is often characterized by body temperature over 105 degrees, dehydration, headache, dizziness, nausea, vomiting, and muscle weakness.


name: Grade 2 Psychosis Including Hallucinations and Delusions, CTCAE


Acute Radiation Skin Toxicity

description: Erythema, desquamation, and other cutaneous injury resulting from, and occurring within days or weeks of, radiation exposure.


name: Stage III Appendix Neuroendocrine Tumor AJCC v7

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor directly invades other adjacent organs or structures, e.g., abdominal wall and skeletal muscle.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Delusions, CTCAE

description: A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.


name: Melanoma of the Conjunctiva pT1a TNM Finding v7

description: Melanoma of the bulbar conjunctiva with tumor measuring not more than 0.5 mm in thickness with invasion of the substantia propria.  (from AJCC 7th Ed.)


name: Nontraumatic Intracerebral Hemorrhage in Cerebellum

description: Evidence of nontraumatic intracerebral hemorrhage in cerebellum.


Nail Discoloration, CTCAE

description: A disorder characterized by a change in the color of the nail plate.


Chronic Myelomonocytic Leukemia-2

description: A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count.


name: Grade 3 Spermatic Cord Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


Ankylosing spondylitis, lumbar region

description: Evidence of ankylosing spondylitis of lumbar region.


name: Grade 1 Partial Thromboplastin Time, CTCAE


name: Thymic Tumor Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of a thymic tumor, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.


N3b TNM Finding

description: A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes.  The definition of N3b TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in clinically detected ipsilateral internal mammary lymph nodes in the presence of one or more positive axillary lymph nodes, or in more than 3 axillary lymph nodes and in internal mammary lymph nodes with micrometastases or macrometastases detected by sentinel lymph node biopsy but not clinically detected; for gastric cancer it refers to metastases in sixteen or more regional lymph nodes; for nasopharyngeal cancer it refers to extension to the supraclavicular fossa.


name: Grade 4 Conjunctiva Intra-Operative Injury, CTCAE


Grade 5 Death NOS, CTCAE

description: Death


Nasopharyngeal Cancer TNM Finding v8

description: A finding about one or more characteristics of nasopharyngeal cancer, following the rules of the TNM AJCC v8 classification system. Epithelial tumors of the nasopharynx are staged using this staging system. Mucosal melanoma, lymphoma, and sarcoma of soft tissue, bone, and cartilage are not included in this classification. (from AJCC 8th Ed.)


name: Grade 5 Pancreatic Anastomotic Leak, CTCAE

description: Death


Grade 4 Neonatal Diarrhea, AE

description: A diarrhea adverse event in a newborn characterized by life-threatening consequences (e.g. severe dehydration).


Birth Complication

description: The development of a problematic medical situation that occurs concurrently with the birth of a neonate.


Grade 2 Diffuse Follicular Lymphoma

description: A follicular lymphoma with diffuse pattern characterized by the presence of 6-15 centroblasts per 40 high-power fields.


Presyncope Related to COVID-19

description: Presyncope in a patient with probable or confirmed acute COVID-19.


name: Rheumatoid Heart Disease with Rheumatoid Arthritis of Left Elbow

description: Evidence of rheumatoid heart disease with rheumatoid arthritis of left elbow.


IDH2 Gene Mutation Negative

description: A genetic finding indicating that IDH2 gene mutations have not been detected in a sample.


name: Hallucinogen Use, Unspecified with Hallucinogen-Induced Psychotic Disorder, Unspecified

description: Evidence of hallucinogen use, unspecified with hallucinogen-induced psychotic disorder.


name: Ann Arbor Stage II AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Grade 3 Thrombosis or Thrombus or Embolism, CTCAE


name: Grade 3 Bladder Intra-Operative Injury, CTCAE


Unresectable Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that is not amenable to surgical resection.


Dissociative Hysteria

description: A disorder characterized by sudden, unexpected travel away from one's home or place of work accompanied by an inability to recall one's past; the individual is confused about his or her personal identity and may assume a new identity.


Stage IIA Bone Cancer AJCC v8

description: Stage IIA includes: T1, N0, M0, G2 or G3. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


name: Duodenum/Ampulla/Jejunum/Ileum Neuroendocrine Tumor Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of duodenum/ampulla/jejunum/ileum neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.


name: Sedative, Hypnotic or Anxiolytic Dependence with Sleep Disorder

description: Evidence of sedative, hypnotic or anxiolytic dependence with sleep disorder.


name: Grade 4 CD4 Lymphocytes Decreased, CTCAE

description: <50/mm3; <0.05 x 10e9/L


Proximal Gastric Adenocarcinoma

description: A gastric adenocarcinoma that arises from the proximal part of the stomach.


name: Grade 4 Abdomen NOS Intra-Operative Injury, CTCAE


Enteropathic Arthropathies, Left Elbow

description: Evidence of enteropathic arthropathies in the left elbow.


Aplastic anemia due to drugs

description: A state of bone marrow suppression and failure that is caused by a cytotoxic or adverse immunologic response to a drug treatment, leading to a failure of production of red blood cells, white cells and platelets.


Contiguous Disease

description: A term that usually refers to the clinical course of lymphomas and indicates that the cancerous lymph nodes are next to each other.


name: Grade 4 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Bone Marrow Hypocellular, CTCAE

description: Moderately hypocellular or >25-<50% reduction from normal cellularity for age


name: Merkel Cell Carcinoma Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of Merkel cell carcinoma, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.  The TNM pathologic and clinical primary tumor classifications of Merkel cell carcinoma are the same. (from AJCC 7th Ed.)


name: Parathyroid Carcinoma pT2 TNM Finding v8

description: Tumor with direct invasion into the thyroid gland. (from AJCC 8th Ed.)


Fallopian Tube Cancer by AJCC v6 Stage

description: A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 6th edition.


Uterine Corpus Sarcoma TNM Finding v8

description: A finding about one or more characteristics of uterine corpus sarcoma, following the rules of the TNM AJCC v8 classification system. This classification system applies to sarcomas arising in the uterine corpus (leiomyosarcomas, endometrial stromal sarcomas, and adenosarcomas). Carcinosarcomas are staged according to the classification for uterine corpus carcinomas and carcinosarcomas. (from AJCC 8th Ed.)


name: Type 2 Diabetes Mellitus with Mild Nonproliferative Diabetic Retinopathy without Macular Edema, Unspecified Eye

description: Evidence of type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema in an unspecified eye.


Fistula of gallbladder

description: An abnormal communication between the gallbladder and another organ or cavity.


name: Merkel Cell Carcinoma Clinical TNM Finding v8

description: A clinical finding about one or more characteristics of Merkel cell carcinoma, following the rules of the TNM AJCC v8 classification system.


name: Oropharyngeal (p16-Negative) Cancer cN0 TNM Finding v8

description: Oropharyngeal (p16-negative) cancer with no metastasis to regional lymph nodes. (from AJCC 8th Ed.)


name: Colorectal Cancer Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of colorectal cancer, following the rules of the TNM AJCC v8 classification system.


Aorticopulmonary Septal Defect

description: A congenital heart malformation characterised by incomplete separation of the truncus arteriosus and the aorticopulmonary trunk, resulting in communication between the aorta and pulmonary trunk.


name: Frontal Lobe and Executive Function Deficit following Unspecified Cerebrovascular Disease

description: Evidence of frontal lobe and executive function deficit following unspecified cerebrovascular disease.


name: Uterine Corpus Adenosarcoma pT3b TNM Finding v8

description: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. (from AJCC 8th Ed.)


Grade 3 Rectal Obstruction, CTCAE

description: Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 3 Bronchial Fistula, CTCAE

description: Invasive intervention indicated


name: Esophagus and Esophagogastric Junction Cancer Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of esophagus and esophagogastric junction cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.


name: Direct Infection of Left Knee in Infectious and Parasitic Diseases Classified Elsewhere

description: Evidence of direct infection of left knee in infectious and parasitic diseases classified elsewhere.


name: Part-Solid Ground-Glass Pulmonary Nodule

description: A term that refers to a pulmonary nodule in which part of the ground-glass opacity completely obscures the parenchyma on CT scan examination.


name: Ampulla of Vater Cancer pNX TNM Finding v7

description: Ampulla of Vater cancer in which the regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


name: Grade 2 Bronchospasm and Wheezing, CTCAE


name: Other specified diabetes mellitus with ketoacidosis, without coma

description: Evidence of other specified diabetes mellitus with ketoacidosis without coma not specified elsewhere.


name: Gastric Cancer Clinical Distant Metastasis TNM Finding v7

description: A clinical finding about one or more characteristics of gastric cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.


name: Perihilar Bile Duct Cancer pT2 TNM Finding v8

description: Perihilar bile duct cancer with tumor invading beyond the wall of the bile duct to surrounding adipose tissue, or tumor invading adjacent hepatic parenchyma. (from AJCC 8th Ed.)


name: Grade 1 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 3 Chylous Ascites, CTCAE

description: Severe symptoms; elective operative intervention indicated


name: Grade 3 Partial Thromboplastin Time, CTCAE


Eruption cyst of jaw

description: A variant of dentigerous cyst found in the soft tissues overlying an erupting tooth. (WHO 2017)


Grade 2 Gastric Perforation, CTCAE

description: Invasive intervention not indicated


name: Drug or Chemical Induced Diabetes Mellitus with Moderate Non-Proliferative Diabetic Retinopathy with Macular Edema, Bilateral

description: Evidence of drug or chemical induced diabetes mellitus with moderate non-proliferative diabetic retinopathy with macular edema that is bilateral.


name: High Grade Gastric Intraepithelial Neoplasia

description: A gastric intraepithelial lesion characterized by the presence of neoplastic cells that are cuboidal with a high nucleus to cytoplasmic ratio, prominent nucleoli, significant architectural changes, and increased number of mitotic figures.


name: Grade 5 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Retinopathy, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Localized Edema, CTCAE

description: A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site.


Grade 3 Ovarian Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Rheumatoid Lung Disease with Rheumatoid Arthritis of Left Elbow

description: Evidence of rheumatoid lung disease with rheumatoid arthritis of left elbow.


name: Monoplegia of Upper Limb following Non-Traumatic Subarachnoid Hemorrhage Affecting Unspecified Side

description: Evidence of monoplegia of upper limb following non-traumatic subarachnoid hemorrhage affecting unspecified side.


name: Grade 5 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acral Edema

description: Accumulation of an excessive amount of watery fluid in cells or intercellular tissues of the hands and feet.


Early Inflammatory Arthritis

description: Early stages of inflammatory arthritis, when the underlying diagnosis is uncertain, usually little or no joint damage has occurred. Treatment may alter the disease course (e.g., potentially avert progression to full RA or other diagnosis).


name: Grade 2 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


name: FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Acute on chronic systolic heart failure

description: Acute decompensation of chronic systolic congestive heart failure.


Diffuse Meningeal Melanocytic Neoplasm

description: A diffuse proliferation of melanocytes that affects the leptomeninges. This category includes melanocytosis and melanomatosis.


name: Adult Acute Myeloid Leukemia with Minimal Differentiation

description: An acute myeloid leukemia with minimal differentiation occurring in adults.


Bladder granuloma

description: A granuloma that develops in the urinary bladder.


name: Atherosclerosis of Non-Biological Bypass Graft(s) of the Left Leg with Ulceration of Thigh

description: Evidence of atherosclerosis of non-biological bypass graft(s) of the left leg with ulceration of thigh.


name: Rheumatoid Bursitis, Right Ankle and Foot

description: Evidence of rheumatoid bursitis in the right ankle and foot.


name: Cerebral Infarction due to Embolism of Left Middle Cerebral Artery

description: Evidence of cerebral infarction due to an embolism of the left middle cerebral artery.


Adverse Event Attributed to Research

description: An indication that an adverse event is causally related to processes a subject was exposed to during a research study.


name: Non-Neoplastic Respiratory System Disorder

description: A non-neoplastic disorder that affects the respiratory system.  Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis.


name: Metastatic Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Distant metastases present at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 1 Lipohypertrophy, CTCAE

description: Asymptomatic and covering <10% BSA


name: PSA Level Greater than or Equal to Fifteen

description: A blood concentration of prostate specific antigen greater than or equal to 15 ng/mL.


name: Slipped Capital Femoral Epiphysis, CTCAE


name: Prostate Ductal Adenocarcinoma, Cribriform Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of neoplastic large back-to-back glands with slit-like lumens.


Increased Drug Half Life

description: Increased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


name: Grade 3 Oral Intra-Operative Injury, CTCAE


Grade 5 Diarrhea, CTCAE

description: Death


Penile Cancer TNM Finding v8

description: A finding about one or more characteristics of penile cancer, following the rules of the TNM AJCC v8 classification system. This classification system applies to penile squamous cell carcinoma and associated histologic subtypes. It does not apply to urethral carcinomas, sarcomas, and melanomas. (from AJCC 8th Ed.)


Adult Pineocytoma

description: A pineocytoma occurring in adults.


name: Type 2 Diabetes Mellitus with Severe Nonproliferative Diabetic Retinopathy without Macular Edema

description: Evidence of type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema.


name: Hallucinogen Dependence with Other Hallucinogen-Induced Disorder

description: Evidence of hallucinogen dependence with other hallucinogen-induced disorder.


description: Evidence of opioid dependence with opioid-induced sexual dysfunction.


name: Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder

description: The reemergence of neoplastic post-transplant lymphoproliferative disorder after a period of remission.


name: Mechanical Complication of Heart Valve Prosthesis, Initial Encounter

description: Evidence of mechanical complication of heart valve prosthesis, initial encounter.


Lung Cancer pN1 TNM Finding v8

description: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension. (from AJCC 8th Ed.)


name: Grade 5 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Incised wound

description: A wound or cleft resulted from tissue separation into parts or laid open or penetrated with a sharp edge or instrument.


name: Diabetes Mellitus due to Underlying Condition with Mild Non-Proliferative Diabetic Retinopathy without Macular Edema, Left Eye

description: Evidence of diabetes mellitus due to underlying condition with mild non-proliferative diabetic retinopathy without macular edema in the left eye.


name: Esophagus and Esophagogastric Junction Cancer TNM Finding v8

description: A finding about one or more characteristics of esophagus and esophagogastric junction cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to carcinomas including squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, undifferentiated carcinoma, neuroendocrine cancers, and adenocarcinoma with neuroendocrine features. Sarcomas, nonepithelial cancers, and gastrointestinal stromal tumors are not staged using this staging system. (from AJCC 8th Ed.)


name: Ataxia following Other Cerebrovascular Disease

description: Evidence of ataxia following other cerebrovascular disease.


Grade 4 Gallbladder Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Hemorrhoids, CTCAE 5.0

description: A disorder characterized by the presence of dilated veins in the rectum and surrounding area.


name: Appendiceal Carcinoid pN0 TNM Finding v7

description: Appendiceal carcinoid without regional lymph node metastasis.  (from AJCC 7th Ed.)


name: Unresectable Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that is not amenable to surgical resection.


name: Diffuse Large B-Cell Lymphoma, Intra-abdominal Lymph Nodes

description: Evidence of diffuse large B-cell lymphoma, intra-abdominal lymph nodes.


Overlapping malignant melanoma of skin

description: Evidence of a malignant melanoma of the overlapping sites of the skin.


name: atherosclerosis of other type of bypass graft of extremities with ulceration

description: Evidence of atherosclerosis of other type of bypass graft(s) of extremity with ulceration.


name: Unresectable Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that is not amenable to surgical resection.


Laryngeal Edema, CTCAE

description: A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx.


name: Grade 2 Slipped Capital Femoral Epiphysis, CTCAE


description: An epithelioid hemangioendothelioma that is not amenable to surgical resection.


Genetic Fusion Negative

description: An indication that genetic fusions were not detected in a sample.


name: Duodenum and Ampulla of Vater Neuroendocrine Tumor cM1b TNM Finding v8

description: Duodenum and ampulla of Vater neuroendocrine tumor with metastasis in at least one extrahepatic site (e.g., lung, ovary, nonregional lymph node, peritoneum, bone). (from AJCC 8th Ed.)


Fallopian Tube Cancer by AJCC v8 Stage

description: A term that refers to the staging of fallopian tube cancer according to the American Joint Committee on Cancer, 8th edition.


Vaginal Cancer cM0 TNM Finding v8

description: Vaginal cancer without evidence of distant metastasis. (from AJCC 8th Ed.)


name: Mediastinal Germ Cell Tumor T2b TNM Finding

description: Mediastinal germ cell tumor infiltrating contiguous organs or accompanied by malignant effusion and measuring more than 5 cm. (WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart, 2015)


name: Grade 1 Intraoperative Hepatobiliary Injury, CTCAE

description: Primary repair of injured organ/structure indicated


name: gestational diabetes mellitus in childbirth, diet controlled

description: Evidence of gestational diabetes mellitus in childbirth that is diet controlled.


name: Colorectal Neuroendocrine Tumor pNX TNM Finding v8

description: Colorectal neuroendocrine tumor in which the regional lymph nodes cannot be assessed.  (from AJCC 8th Ed.)


Grade 5 Hallucinations, CTCAE

description: Death


name: Adenocarcinoma with spindle cell metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to spindle-shaped cells.


name: Other Specified Rheumatoid Arthritis, Unspecified Knee

description: Evidence of other specified rheumatoid arthritis in an unspecified knee not specified elsewhere.


name: Grade 5 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Gastric Cancer Clinical Distant Metastasis TNM Finding v8

description: A clinical finding about one or more characteristics of gastric cancer, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Grade 3 Phrenic Nerve Dysfunction, CTCAE


Tumor Leakage

description: The loss of a fluid from a tumor. This can occur under normal circumstances or during biopsy or other surgical procedure.


Grade 3 Colitis, CTCAE

description: Severe abdominal pain; peritoneal signs


name: Bronchus Obstruction and Stenosis, CTCAE


name: Grade 5 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Periodontal Disease, CTCAE

description: Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss


Unresectable Cervical Carcinoma

description: Cervical carcinoma that is not amenable to surgical resection.


Grade 4 Endophthalmitis, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


name: Grade 2 Somnolence and Depressed Level of Consciousness, CTCAE


name: Small Bowel Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Sicca Syndrome with Lung Involvement

description: Evidence of Sicca syndrome with lung involvement.


name: Squamous cell carcinoma in situ with questionable stromal invasion

description: A malignant epithelial neoplasm involving all the layers of the squamous epithelium, but it is not certain if it is confined to the squamous epithelium or it has invaded the basement membrane and the underlying stroma.


name: Merkel Cell Carcinoma pTX TNM Finding v7

description: Merkel Cell Carcinoma in which the primary tumor cannot be assessed. (from AJCC 7th Ed.)


Enteropathic Arthropathies, Right Hand

description: Evidence of enteropathic arthropathies in the right hand.


Stage II Uterine Corpus Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Fallopian Tube Cancer Clinical TNM Finding v7

description: A clinical finding about one or more characteristics of fallopian tube cancer, following the rules of the TNM AJCC v7 classification system.


name: Adverse Event Associated with Cardiac Arrhythmia


Serum CEA Level Finding

description: A finding that indicates the amount of carcinoembryonic antigen (CEA) in a serum sample.


Cancer-related Cognitive Dysfunction

description: The effects of cancer and its treatments on cognitive processes.


name: Grade 5 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Gastrointestinal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Sarcoma of the Orbit pT3 TNM Finding v7

description: Sarcoma of the orbit with tumor of any size with invasion of orbital tissues and/or bony walls.  (from AJCC 7th Ed.)


name: Grade 4 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


name: Mucosal Melanoma of the Head and Neck pN1 TNM Finding v7

description: Mucosal melanoma of the head and neck with regional lymph node metastases. (from AJCC 7th Ed.)


name: Cutaneous Follicular Center Lymphoma, Intrapelvic Lymph Nodes

description: Evidence of cutaneous follicular center lymphoma in the intrapelvic lymph nodes.


Prostate cancer stage D

description: Metastatic disease.


Polyp of esophagus

description: A benign intraluminal polypoid neoplasm of the esophagus.  It includes the squamous papilloma and the giant fibrovascular polyp.


name: Grade 4 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


S-sulfo-L-cysteine

An S-substituted L-cysteine where the S-substituent is specified as a sulfo group.


A phenol that is 2-phenylethanol in which the phenyl ring is substituted at position 2 by a hydroxy group.


2-deoxy-D-ribose 5-phosphate

The 5-O-phosphono derivative of 2-deoxy-D-ribose.


2-deoxy-D-ribofuranose 5-phosphate

The furanose form of 2-deoxy-D-ribose 5-phosphate.


azanigerone D

An azaphilone that is the ester obtained by formal condensation of the carboxy group of 2,4-dimethylhexanoic acid with the tertiary hydroxy group of 7-hydroxy-7-methyl-6,8-dioxo-2,6,7,8-tetrahydroisoquinoline-3-carboxylic acid.


An amino trisaccharide consisting of beta-lactose and 2-acetamido-2-deoxy-alpha-D-galactopyranose joined by a (1->6) glycosidic bond.


A 2,6-diaminopurine that is an analogue of abacavir in which the cyclopropylamino group at position 6 of the purine moiety is replaced by a 3-methoxyazetidin-1-yl group. One of a series of synthesised abacavir analogues with antiviral activity found to stimulate IFN-gamma secretion in abacavir-responsive clones.


The Z (syn) isomer of testosterone-3-CMO-Hist.


A chlorophenylmethane that is methane in which two of the hydrogens have been replaced by p-chlorophenyl groups.


chlorophenylmethane

A chlorohydrocarbon that is phenylmethane substituted by a chloro group at unspecified position.


name: 4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester


name: 2-[4-[[(3,4-dichlorophenyl)-oxomethyl]amino]phenyl]-3,3,3-trifluoro-2-hydroxypropanoic acid ethyl ester


name: 3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester


name: 4-chloro-1-methyl-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester


name: amyotrophic lateral sclerosis, susceptibility to, 24


desulfated gastrin-17

One of the primary forms of gastrin that is a 17-membered peptide consisting of Glp, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe-NH2 residues joined in sequence.


One of the primary forms of gastrin that is a 14-membered peptide consisting of Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe residues joined in sequence.


One of the primary forms of gastrin that is a 34-membered peptide consisting of Gln, Leu, Gly, Pro, Gln, Gly, Pro, Pro, His, Leu, Val, Ala, Asp, Pro, Ser, Lys, Lys, Gln, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe residues joined in sequence.


A trans-1,2-dihydronaphthalene-1,2-diol with a (1R,2R)-configuration.


The (1S,2S)-isomer of trans-1,2-dihydronaphthalene-1,2-diol.


METHAMPHETAMINE HYDROCHLORIDE

A hydrochloride having methamphetamine as the base component.


An alpha-oxyketone that consists of propiophenone bearing an alpha-hydroxy substituent.


A proline derivative having a 2,4-dinitrophenyl substituent on nitrogen.


angelic acid

The (Z)-isomer of 2-methylbut-2-enoic acid. It is found in plant species of the family Apiaceae.


PAROMAMINE

An aminoglycoside that is 4alpha,6alpha-diaminocyclohexane-1beta,2alpha,3beta-triol in which the pro-R hydroxy group has been converted into its 2-amino-alpha-D-glucoside derivative.


zuranolone

A 3-hydroxy steroid that is 5beta-19-norpregnane substituted by hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20 and 21, respectively. It is a positive allosteric modulator of GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults.


19-O-acetylchaetoglobosin A

A cytochalasan alkaloid that is the acetyl derivative of chaetoglobosin A. It has been isolated from Chaetomium globosum and Chaetomium brasiliense.


A 3beta-sterol that consists of 24-methylcholest-6-en-3beta-ol with a peroxy group between positions 5 and 8 and a methylene group between positions 22 and 23. An antineoplastic agent isolated from  Sinularia sp.


captafol

A dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community.


A hydroxy monocarboxylic acid consisting of icosa-5,9,14-trienoic acid having three hydroxy groups placed at the 8-, 11- and 12-positions.


An oligosaccharide sulfate consisting of 2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid and 2-acetamido-2-deoxy-alpha-D-glucopyranose residues joined in sequence by a (1->4) glycosidic linkage.


A hydrobromide salt prepared from N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.


1,2,3,6-tetrahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is 1,3,3a,4,7,7a-hexahydro-2-benzofuran carrying oxo groups at positions 1 and 3.


methylhexahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is the cyclic anhydride of methylhexahydrophthalic acid.


methyltetrahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is the cyclic anhydride of methyltetrahydrophthalic acid.


hexahydrophthalic anhydride

A cyclic dicarboxylic anhydride that is the cyclic anhydride of hexahydrophthalic acid.


3-methylsuccinic anhydride

A tetrahydrofurandione that is succinic anhydride substituted by  a methyl group at position 3.


GALACTITOL

An optically inactive hexitol having meso-configuration.


caprolactams

A lactam in which the amide bond is contained within a seven-membered ring, which includes the amide nitrogen and the carbonyl carbon.


ciliatamide A

A lipopeptide that contains N-methylphenylalanine and lysine as the amino acid residues linked to a dec-9-enoyl moiety via an amide linkage (the R,R stereoisomer). It is isolated from the deep sea sponge Aaptos ciliata and exhibits antileishmanial activity.


CAPROLACTAM

A member of the class of caprolactams that is azepane substituted by an oxo group at position 2.


A member of the class of  caprolactams that is epsilon-caprolactam which carries an acetyl group at position 3.


ciliatamide B

A lipopeptide that contains N-methylphenylalanine and lysine as the amino acid residues linked to a octanoyl moiety via an amide linkage (the R,R stereoisomer). It is isolated from the deep sea sponge Aaptos ciliata and exhibits antileishmanial and moderate cytotoxicity towards HeLa cells.


A secondary carboxamide that is anthranilic acid in which the carboxy group has undergone condensation with the primary amino group of alpha-amino-epsilon-caprolactam, while the aryl-amino group has undergone condensation with the carboxy group of 1-benzothiophene-2-carboxylic acid. It is a selective, non-competitive antagonist of tropomyosin receptor kinase B (TrkB, also known as tyrosine receptor kinase B).


An  amino acid amide obtained by the intramolecular condensation of the terminal amino group with the carboxy group in lysine.


1-naphthaleneacetic acid

A naphthylacetic acid substituted by a carboxymethyl group at position 1.


A galactotriose consisting of two alpha-D-galactopyranose and a D-galactopyranose residues joined in sequence by (1->3) gllycosidic bonds.


A 2-hydroxy-6-oxonona-2,4,7-trienedioic acid having (2E,4Z,7E)-configuration.


An amino trisaccharide consisting of two 2-acetamido-2-deoxy-beta-D-glucopyranose residues and an alpha-D-galactopyranose residue joined in sequence by (1->6) glycosidic bonds.


A  monocarboxylic acid amide, being a derivative of (3,5-dioxopyrazolidin-4-yl)acetamide substituted at nitrogen by a 5-carboxypentyl chain.


The organoammonium salt formed from equimolar amounts of N(6)-(3,5-dioxo-1,2-diphenylpyrazolidin-4-ylacetyl)-6-aminohexanoic acid (Butaz) and hydrogen chloride.


oxyphenbutazone

A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.


An ethyl ester resulting from the formal condensation of the carboxy group of 4-{4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoic acid with ethanol. It is an irreversible and cell-permeable inhibitor of ubiquitin-activating enzyme E1.


A PYR-41 that has (E)-configuration.


An amino disaccharide consisting of 2-acetamido-2-deoxy-alpha-D-galactopyranose and D-galactopyranose residues joined in sequence by a (1->6) glycosidic bond.


heptacene

An acene that consists of seven ortho-fused benzene rings in a rectilinear arrangement.


acene

A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement.


nonacene

An acene that consists of nine ortho-fused benzene rings in a rectilinear arrangement.


hexacene

An acene that consists of six ortho-fused benzene rings in a rectilinear arrangement.


An  organic heterotetracyclic compound that is 3,4-dihydro-2H,12H-pyrano[2,3-a]xanthen-12-one substituted by hydroxy groups at positions 5 and 9, a methoxy group at position 10, two methyl groups at position 2, a prenyl group at position 11 and an oxo group at position 12.


name: 1-[2-(3,4-dimethoxyphenyl)-1-oxoethyl]-4-piperidinecarboxylic acid methyl ester


PESCAPREIN XXI

A  resin glycoside that is  the pentasaccharide derivative of  jalapinolic acid. Isolated from the aerial parts of Ipomoea pes-caprae, it has been found to exhibit potential inhibitory effect against multidrug resistance in the human breast cancer cell line


alpha-C-GalCer

A neoglycosphingolipid that is a synthesized C-glycosyl analogue of myelin-derived galactosylceramide (Mye-GalCer).


name: Creatinine sulfate mixture with serotonin


An N-acetyl-beta-D-glycosaminyl glycopeptide consisting of an N-acetyl-beta-D-glycosaminyl-(1->4)-N-acetylmuramoyl moiety attached to the amino terminus of the dipeptide L-alanyl-D-isoglutamine.


L-adenosylselenohomocysteine

A selenoamino acid that is L-selenomethionine in which the methyl group attached to the selenium is replaced by a 5'-adenosyl group.


A secondary alcohol that is nonane substituted by a hydroxy group at position 5.


A 4-hydroxy-D-proline in which the hydroxy group at position 4 has R-configuration.


A D-proline derivative that is D-proline monohydroxylated at position 3 (the cis-3-hydroxy-diastereomer).


The (3S)-trans-diastereomer of 3-hydroxy-L-proline.


hydroxyproline

A proline derivative that is proline substituted by at least one hydroxy group.


A L-proline derivative that is L-proline substituted by hydroxy groups at positions 3 and 4 (the 3S,4S diastereoisomer).


The L-enantiomer of  4-oxoproline.


A hydroxyproline that is L-proline substituted by a hydroxy group at position 2.


The (3R)-trans--diastereomer of 3-hydroxy-D-proline.


The D-stereoisomer of 4-hydroxyproline.


The L-stereoisomer of 3-hydroxyproline.


monohydroxyproline

A hydroxy-amino acid in which the amino acid specified is proline. A "closed" class.


dihydroxyproline

A hydroxyproline that is proline substituted by two hydroxy substituents.


pyroglutamic acid

An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.


oxoproline

A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent.


An  aminopyrrolidine that is D-proline substituted by a amino group at position 5 and a methyl group at position 3.


The 4-isomer of oxoproline.


The (3R)-cis-diastereomer of 3-hydroxy-L-proline.


name: 4,5-dioxo-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid ethyl ester


A monohydroxyproline in which the hydroxy substituent is located at position C3.


An optically active form of 4-hydroxyproline having L-trans-configuration.


The L-stereoisomer of 4-hydroxyproline.


A 4-hydroxyproline substituted at N-1 by an ethoxycarbonyl group.


The D-enantiomer of 5-oxoproline.


L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).


A 4-hydroxyproline substituted at N-1 by an methoxyacetyl group.


A N-acylpyrrolidine that is proline substituted by a propanoyl group at the nitrogen atom.


A lignan that consists of tetrahydrofuran substituted by a 3,4-dihydroxyphenyl group at position 2, a hydroxymethyl group at position 3 and a hydroxy(4-hydroxy-3-methoxyphenyl)methyl group at position 4. It has been isolated from Taxus yunnanensis.


progesterone 3-O-(carboxymethyl)oxime

An oxime O-ether consisting of progesterone having an O-(carboxymethyl)oxime group at the 3-position.


(R)-clenbuterol hydrochloride

The monohydrochoride salt of (R)-clenbuterol.


Ala-Ala zwitterion

A dipeptide zwitterion resulting from the transfer of a proton from the carboxy to the amino group of Ala-Ala; major species at pH 7.3.


name: cis-5,8,11-Eicosatrienoic acid methyl ester


An anthocyanidin glucoside having a 6-O-malonylglucosyl residue at the 3-position attached via a beta-linkage.


A purine 2',3'-dideoxyribonucleoside in which the nucleobase component is specified as adenine.


selenium-77 atom

A stable isotope of selenium with relative atomic mass 76.919915, 7.60 atom percent natural abundance and nuclear spin 1/2.


selenium-82 atom

A stable isotope of selenium with relative atomic mass 81.91670, 8.82 atom percent natural abundance and nuclear spin 0.


(+)-dihydroisorhamnetin

A dihydroisorhamnetin that has 2R,3R-configuration.


A sialodiosylceramide consisting of the tetrasaccharide alpha-N-glycoloylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose attached to the primary hydroxy function of a ceramide with undefined sphingoid base.


2-aminooctanoic acid zwitterion

An alpha-amino acid zwitterion that is 2-aminooctanoic acid in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3.


lactose 6'-phosphate

A lactose phosphate in which a single monophosphate substituent is placed at position 6 on the galactose ring of lactose.


leupeptin hemisulfate

A peptide sulfate salt obtained by combining leupeptin with 0.5 molar equivalents of sulfuric acid.


colistin B sulfate

The sulfuric acid salt of colistin B.


colistin A sulfate

The sulfuric acid salt of colistin A.


A  fluorobenzoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-fluorobenzoic acid.


The (25R)-diastereomer of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al.


An acyl-CoA thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2-naphthoic acid..


colchicine

An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.


(R)-colchicine

A colchicine that has (R)-configuration.


A glucosylceramide consisting of a beta-D-glucosyl residue attached to the primary hydroxyl group of N-acyl-(4E,6E)-hexadecasphingadienine.


A monocarboxylic acid amide obtained by formal condensation between N-butyl-3,3-dimethoxyalaninamide and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid.


An antiviral lignan isolated from Larrea tridentata, which consists of a 3,4-dimethyltetrahydrofuran skeleton substituted by a dihydroxybenzyl and hydroxyphenyl groups at position 2 and 5 respectively (the 2R,3S,4R,5R stereoisomer).


tensyuic acid F

A tensyuic acid that is itaconic acid which has been substituted at position 3 by a 3-(ethoxycarbonyl)propyl group. The (-)-isomer, isolated from Aspergillus niger FKI-2342.


haloindole

A compound based on an indole skeleton, containing one or more halogen atoms


curacomycin

A homodetic cyclic peptide found in several Streptomyces species, consisting of 3-hydroxyasparagine, L-ornithine, L-isoleucine, D-leucine, D-valine and 5-chloro-L-tryptophan joined in sequence in a cyclic arrangement by peptide linkages. It exhibits antibacterial properties.


fluoroindole

An organofluorine compound that is a compound based on an indole skeleton, containing one or more fluorine atoms.


spongotine A

A member of the class of imidazolines that is 4,5-dihydro-1H-imidazole which is substituted by a 1H-indole-3-carbonyl group at position 2 and a 6-bromo-1H-indol-3-yl group at position 4S. It is a bisindole alkaloid isolated from the marine sponge, Spongosorites sp.


A member of the class of indoles obtained by dimerisation of 2-imino-3-(7-chloroindol-3-yl)propanoic acid.


amisulbrom

A member of the class of bromoindoles that is 3-bromo-6-fluoro-2-methylindole substituted at position 1 by a 1-(dimethylsulfamyl)-1,2,4-triazole-3-sulfonyl group. A fungicide for use on potatoes to control late blight (Phytophthora infestans) and downy mildew [Plasmopara viticola). It has a low mammalian toxicity but it is considered to be a reproduction toxicant, is moderately toxic to birds and honey bees but poses a greater risk to aquatic species and earthworms.


bromoindole

An organobromine compound that is a compound based on an indole skeleton, containing one or more bromine atoms.


A fluoroindole that is 1H-indole substituted by a beta-D-glucopyranosyl, 4-cyclopropylbenzyl, and fluoro groups at positions 1, 3 and 4, respectively. It is a highly potent and selective SGLT2 inhibitor, with antihyperglycemic effects in high-fat diet-fed KK mice.


A 7-chlorotryptophan in which the chiral centre has D- (R-) configuration.


brivanib

A secondary alcohol resulting from the hydrolysis of the carboxylic ester group of brivanib alaninate. It is a dual VEGFR-2/FGFR-1 kinase inhibitor whose alanine prodrug, brivanib alaninate is currently under development as an oral agent for the treatment of cancer.


An organofluorine compound that is the 5-fluoro derivative of indole.


A non-proteinogenic alpha-amino acid that is tryptophan in which the hydrogen at position 5 on the indole ring is replaced by a bromo group.


N-bromoindole

A compound based on an indole skeleton with a bromine atom bonded to the nitrogen atom of the indole.


aetokthonotoxin

A bromoindole that is 2,3,5-tribromo-1H-indole which is substituted by a 5,7-dibromo-3-cyano-1H-indol-2-yl group at position 1. It is a biindole alkaloid isolated from the cyanobacterium Aetokthonos hydrillicola and causes vacuolar myelinopathy in bald eagles.


An L-tryptophan derivative having a chloro substituent at the 7-position.


dichlorochromopyrrolic acid

A pyrrole-2,5-dicarboxylic acid having 7-chloroindol-3-yl groups at the 3- and 4-positions.


indisulam

A chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development.


A bromoamino acid that is L-tryptophan in which the hydrogen at position 6 of the indole ring is substituted by bromine.


A tryptophan derivative having a chloro substituent at the 7-position of the indole ring.


brivanib alinate

A carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas.


indolauxipyr

A fluoroindole that is indole substituted by a 4-amino-6-carboxy-5-chloro-3-fluoropyridin-2-yl group at position 6 and by a fluoro group at position 7. It is a herbicide developed by Corteva Agriscience and sold as the corresponding ester, indolauxipyr-cyanomethyl.


A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin.


5-bromo-4-chloro-3-indolyl octanoate

A carboxylic ester obtained by formal condensation of the carboxy group of octanoic (caprylic) acid with the hydroxy group of 5-bromo-4-chloroindoxyl.


chloroindole

A compound based on an indole skeleton, containing one or more chlorine atoms


5-bromo-3-indolyl decanoate

An decanoate ester obtained by formal condensation of the carboxy group of decanoic acid with the hydroxy group of 5-bromoindoxyl.


indolauxipyr-cyanomethyl

A carboxylic ester resulting from the formal condensation of the carboxy group of indolauxipyr with hydroxyacetonitrile. It is a herbicide developed by Corteva Agriscience.


5-bromo-4-chloro-3-indolyl acetate

An acetate ester obtained by formal condensation of the carboxy group of acetic acid with the hydroxy group of 5-bromo-4-chloroindoxyl.


N-chloroindole

A chloroindole that is a compound based on an indole skeleton with a chlorine atom bonded to the nitrogen atom of the indole.


BROMODEOXYTOPSENTIN

An aromatic ketone that is imidazole which is substituted by a 1H-indole-3-carbonyl group and a 6-bromo-1H-indol-3-yl group at  positions 2 and 4, respectively. Isolated from the Mediterranean shallow-water sponge, Topsentia genetrix. It is a potent inhibitor of MRSA pyruvate kinase and exhibits antibacterial properties.


A derivative of vindoline lacking the 11-O-methyl and 17-O-acetyl substituents.


name: 2-(4-fluorophenyl)-4-quinolinecarboxylic acid [2-oxo-2-(2-oxolanylmethylamino)ethyl] ester


A very long-chain primary fatty alcohol that is  heptacosan-1-ol substituted by a methyl group at position 26.


meadowlactone

A delta-lactone obtained by intramolecular condensation of the 5-hydroxy and carboxy groups of 5-hydroxyicosanoic acid. A nonenzymatic oxidation product of arachidonic acid.


A 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid that is the (R)-enantiomer of KI16425.


A tripeptide resulting from the formal condensation of the carboxy group of N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valine with the amino group of benzyl (2E,4S)-4-(L-leucylamino)-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate. It is an inhibitor of the main protease of SARS-CoV-2.


An isoxazole that is 3-isoxazoline substituted at position 5 by an oxo group.


dafadine D

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(3-trifluoromethylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a 5-oxoisoxazolin-2-yl group.


TOPRAMEZONE

An aromatic ketone that is phenyl 1H-pyrazol-4-yl ketone in which the pyrazolyl group is substituted at positions 1 and 5 by methyl and hydroxy groups, respectively, and in which the phenyl group is substituted at positions 2, 3, and 4 by methyl, 4,5-dihydro-1,2-oxazol-3-yl, and methylsulfonyl groups, respectively. A potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD) that is rapily metabolised by corn to non-active substances, it is used as a herbicide for the treatment of broadleaf weeds.


An isoxazole compound having a methyl substituent at the 3-position and a 5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl substituent at the 5-position.


dafadine O

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(3-methoxyphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


dafadine C

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2,6-difluorophenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


5-methyl-3-isoxazolyl sulfate

A heterocyclyl sulfate that is 1,2-oxazol-3-yl hydrogen sulfate substituted by a methyl group at position 5.


A member of the class of isoxazoles that is L-alanine in which one of the methyl hydrogens is replaced by a 5-oxoisoxazolin-4-yl group.


sparsentan

A biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression.


dafadine A

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine.


A member of the class of isoxazoles carrying phenyl, 2-aminopyrimidin-4-yl and methyl substituents at positions 3, 4 and 5 respectively.


A member of the class of phenylureas that is urea in which one of the nitrogens has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group, while the other has been substituted by a 3-fluoro-4-hydroxyphenyl group, the hydroxy group has been converted to the corresponding 1H-pyrazolo[3,4-d]pyrimidin-4-yl ether. It is an FLT3 (fms-like tyrosine kinase 3)and Wnt/beta-catenin signaling inhibitor.


dafadine B

An N-acylpiperidine obtained by formal condensation of the carboxy group of 5-[(2-chloro-4-fluorophenoxy)methyl]-1,2-oxazole-3-carboxylic acid with the secondary amino group of 4-(pyridin-4-yl)piperidine


isoxicam

A monocarboxylic acid amide that is piroxicam in which the pyrid-2-yl group is replaced by a 5-methyl-1,2-oxazol-3-yl group. A non-steroidal anti-inflammatory drug, it was withdrawn from the market in the 1980s following its association with cases of Stevens-Johnson syndrome.


N-acetylsulfamethoxazole

A sulfonamide compound having a 4-acetamidophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.


praliciguat

A member of the class of pyrazoles that is 5-fluoro-2-(1H-pyrazol-3-yl)pyrimidine which is substituted by a 2-fluorobenzyl group at position 1, 1,2-oxazol-3-yl group at position 5, and by a [3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]nitrilo group at position 4. It is a soluble guanylate cyclase stimulator under clinical development for the treatment of heart failure with preserved ejection fraction.


(S)-ATPA

A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a 5-tert-butyl-3-hydroxy-isooxazol-4-yl group.


A 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid that is the (S)-enantiomer of KI16425.


lotilaner

A member of the class of isoxazoles that is 4,5-dihydro-1,2-oxazole substituted by 4-methyl-5-({2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}carbamoyl)thiophen-2-yl, trifluoromethyl, and 3,4,5-trichlorophenyl groups at positions 3, 5 and 5, respectively (the 5S-stereoisomer). It is a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor selective for mites, approved for the treatment of Demodex blepharitis.


Ser-Asp-Lys

A tripeptide composed of L-serine, L-aspartic acid and L-lysine amino acids joined in sequence by peptide linkages.


peptide aptamer

An aptamer that is an artificial protein selected or engineered to bind a specific target molecule.


methyl propenyl ketone

An enone that is pent-2-ene in which the two methylene hydrogens have been replaced by an oxo group.


A methyl propenyl ketone in which the double bond has (E)-configuration. It is a key odorant responsible for the chestnut-like aroma in green tea.


magnesium dichloride monohydrate

A hydrate that is the monohydrate form of magnesium dichloride.


3-vinylbacteriochlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-vinylbacteriochlorophyll a.


protochlorophyllide

An analogue of chlorophyll that lacks the phytol side-chain. The parent of the protochlorophyllide class.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 12-ethyl-8-propyl-3-vinylbacteriochlorophyll d.


bacteriochlorophyllide c

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll c.


name: magnesium 13(1)-hydroxyprotoporphyrin 13-monomethyl ester


name: magnesium protoporphyrin 13-monomethyl ester


CaMn4O5 cluster

A  metal-oxygen cluster containing 1 calcium atom, 4 managanese atoms and 5 oxygen atoms. It is the catalytic center of water oxidation in photosystem II (PSII).


bacteriochlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of bacteriochlorophyll a.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any 7(1),7(1)-dihydroxybacteriochlorophyll d.


bacteriochlorophyll

Chlorophylls of photosynthetic bacteria.


chlorophyllide

Chlorophylls lacking the terpenoid side chain such as phytyl or farnesyl.


bacteriochlorophyllide g

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of bacteriochlorophyll g.


7,7-dihydroxybacteriochlorophyllide c

A chlorophyllide in which two of the methyl hydrogens at position 7 of any bacteriochlorophyllide c have been replaced by hydroxy groups.


magnesium protoporphyrin(2-)

The conjugate base of magnesium protoporphyrin, formed by deprotonation of the carboxyethyl groups at C-13 and C-17. It is the principal species at pH 7.3.


bacteriochlorophyllide e

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll e.


3-vinylbacteriochlorophyllide d

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-vinylbacteriochlorophyll d.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyll d.


2,4-divinyl protochlorophyllide a

A protochlorophyllide compound having vinyl substituents at the 2- and 4-positions.


chlorophyll a'

Chlorophyll a' is the C13(2)-epimer of chlorophyll a.


7(1)-hydroxybacteriochlorophyllide d

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any 7(1)-hydroxybacteriochlorophyll d.


bacteriochlorophyll c

A chlorophyll of photosynthetic bacteria, for example green sulfur bacteria.


bacteriochlorophyllide f

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll f.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-(1-hydroxyethyl)bacteriochlorophyll a.


geranylgeranyl bacteriochlorophyllide a

A chlorophyll that is the ester obtained by formal condensation between the carboxy group of bacteriochlorophyllide a and the hydroxy group of geranylgeraniol.


divinyl chlorophyll a

A carboxylic ester obtained by formal condensation of the carboxy group of divinyl chlorophyll a with the hydroxy group of (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol.


A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 8,12-diethyl-3-vinylbacteriochlorophyll d.


divinyl chlorophyll b

A carboxylic ester obtained by formal condensation of the carboxy group of divinyl chlorophyll b with the hydroxy group of (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol.


7(1)-hydroxychlorophyll a

A member of the class of chlorophyll that is chlorophyll a substituted at position 7(1) by a hydroxy group.


name: magnesium 13(1)-oxoprotoporphyrin 13-monomethyl ester


3-(1-hydroxyethyl)chlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-(1-hydroxyethyl)chlorophyll a.


3-acetylchlorophyllide a

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of 3-acetylchlorophyll a.


geranylgeranyl-chlorophyll a

A chlorophyll that is the ester obtained by formal condensation between the carboxy group of chlorophyllide a and the hydroxy group of geranylgeraniol.


magnesium dichloride dihydrate

A hydrate that is the dihydrate form of magnesium dichloride.


bacteriochlorophyllide d

A chlorophyllide obtained by hydrolysis of the terpenoid ester moiety of any bacteriochlorophyll d.


UDP-beta-L-rhamnose

A UDP-L-rhamnose in which the rhamnose portion has beta-configuration at its anomeric centre


UDP-rhamnose

A UDP-sugar in which the sugar component is rhamnose.


UDP-L-rhamnose

A UDP-rhamnose in which the rhamnose component has L-configuration.


flumorph

A mixture comprising approximately equal amounts of (E)- and (Z)-fluomorph. It is used as an agrochemical fungicide for the control oomcyetes such as downey mildew on vegetables and grapes.


morpholine antifungal agent

A member of the class of morpholines that has significant antifungal properties.


aldimorph

A mixture of containing 65-75% 4-alkyl-2,6-dimethylmorpholines and 35-25% 4-alkyl-2,5-dimethylmorpholines, where more than 85% of the total has dodecyl as the alkyl group, and where 'alkyl' may also be octyl, decyl, tetradecyl or hexadecyl, and where the cis:trans ratio is 1:1. Formerly used as a fungicide for the control of powdery mildew in cereal crops, it is no longer approved for use within the European Union.


(Z)-dimethomorph

An enamide resulting from the formal condensation of (2Z)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acrylic acid with the amino group of morpholine. The agricultural fungicide dimethomorph is a mixture of (E)- and (Z)-dimethomorph; only the Z isomer has fungicidal activity.


tridemorph

A mixture of 4-alkyl-2,6-dimethylmorpholines, where 'alkyl' is a mixture of C11 to C14 homologues of which 60-70% is tridecyl. A systemic fungicide, it is no longer approved for use within the European Union.


morpholine fungicide

Any morpholine antifungal agent used as a fungicide.


amorolfine hydrochloride

A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used for the topical treatment of fungal nail and skin infections.


dodemorph

A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a cyclododecyl group. It is a fungicide used for the control of powdery mildew, particularly in rose culture.


DIMETHOMORPH

A mixture of (E)- and (Z)-dimethomorph in an unspecified ratio. It is used as a systemic fungicide used on vines, potatoes, and greenhouse crops; only the Z isomer has fungicidal activity.


morpholine antifungal drug

Any morpholine antifungal agent used to treat fungal infections in humans or animals.


leprostatic drug

A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions.


name: EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor

description: A DNA polymerase inhibitor that interferes with the action of a DNA-directed DNA polymerase (EC 2.7.7.7).


antipruritic drug

A drug, usually applied topically, that relieves pruritus (itching).


miotic

An agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils.


mTOR inhibitor

A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.


histaminergic drug

Drugs used for their actions on histaminergic systems.


HIV-1 integrase inhibitor

An inhibitor of HIV-1 integrase, an enzyme required for the integration of the genetic material of the retrovirus into the DNA of the infected cells.


trypanocidal drug

A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.


sweetening agent

Substance that sweeten food, beverages, medications, etc.


Lewis acid

A molecular entity that is an electron-pair acceptor and therefore able to form a covalent bond with an electron-pair donor (Lewis base), thereby producing a Lewis adduct.


adrenergic agonist

An agent that selectively binds to and activates adrenergic receptors.


potassium ionophore

Any ionophore capable of transportation of potassium ions across membranes.


cytokinin

A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.


antitreponemal drug

A drug used in the treatment of infections with bacteria of the genus Treponema.


name: EC 5.99.1.2 (DNA topoisomerase) inhibitor

description: A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.


topoisomerase inhibitor

An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).


cholinergic agonist

Any drug that binds to and activates cholinergic receptors.


tranquilizing drug

A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour.


EC 3.5.2.6 (beta-lactamase) inhibitor

An EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor that interferes with the action of beta-lactamase (EC 3.5.2.6).


HIV fusion inhibitor

A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS.


growth hormone

A hormone that specifically regulates growth.


thyroid hormone

Any hormone produced by the thyroid gland


coccidiostat

An agent useful in the treatment or prevention of coccidiosis in man or animals.


nicotinic antagonist

An antagonist at the nicotinic cholinergic receptor.


EC 3.2.1.* (glycosidase) inhibitor

An EC 3.2.* (glycosylase) inhibitor that interferes with the action of any glycosidase (i.e. enzymes hydrolysing O- and S-glycosyl compounds, EC 3.2.1.*).


pesticide synergist

A substance that increases the efficacy of a pesticide.


antiparasitic agent

A substance used to treat or prevent parasitic infections.


histamine agonist

A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically.


adrenergic agent

Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.


name: EC 3.5.1.98 (histone deacetylase) inhibitor

description: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).


name: EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor

description: An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of procollagen-proline dioxygenase (EC 1.14.11.2).


enzyme reactivator

Compound which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme.


alpha-adrenergic agonist

An agent that selectively binds to and activates alpha-adrenergic receptors.


name: EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor

description: An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.


dopamine uptake inhibitor

A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.


nutrient

A nutrient is a food component that an organism uses to survive and grow.


name: EC 2.1.1.6 (catechol O-methyltransferase) inhibitor

description: An EC 2.1.1.* (methyltransferase) inhibitor that interferes with the action of catechol O-methyltransferase (EC 2.1.1.6).


protease inhibitor

A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases).


gout suppressant

A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout.


GABA antagonist

A compound that inhibits the action of gamma-aminobutyric acid.


antimanic drug

Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.


keratolytic drug

A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.


central nervous system depressant

A loosely defined group of drugs that tend to reduce the activity of the central nervous system.


name: EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor

description: An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD(+) ADP-ribosyltransferase (EC 2.4.2.30).


antimetabolite

A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.


antiplatyhelmintic drug

An agent used to treat cestode, trematode, or other flatworm infestations in man or animals.


mutagen

An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.


affinity label

An enzyme inhibitor, generally irreversible, that is similar in structure to a particular substrate for a specific enzyme.


GlyTouCan G84452RH

A partially-defined glycan consisting of five hexosyl groups, four acetaminohexosyl groups, a 6-deoxyhexosyl group and an N-acetcylneuraminic acid group (identities and connectivity unknown). Composition: Hex5 HexNAc4 6dHex1 Neu5Ac1.


N-acetyl-beta-neuraminic acid

N-Acetylneuraminic acid with beta configuration at the anomeric centre.


thiomarinol B

A sulfone produced by a marine bacterium Alteromonas rava and has been shown to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria.


D-glyceraldehyde

The D-enantiomer of glyceraldehyde.


A sulfur-containing carboxylic acid consisting of isobutyric acid having mercapto substituents on both beta-carbons.


The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.


A dithiol that is propane substituted by thiol groups at positions 1 ans 3.


unithiol

An alkanesulfonic acid that is propane-1-sulfonic acid substituted by sulfanyl groups at positions 2 and 3.


glucosyl-(heptosyl)2-(KDO)2-lipid A

A lipid A derivative having an alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo moiety attached to the free primary hydroxy group of lipid A.


A galactoglycerolipid that consists of 1,2-diacyl-sn-glycerol having (7Z,10Z)-hexadecadienoyl and linoleoyl as the acyl groups and a 6-O-(alpha-D-galactopyranosyl)-beta-D-galactopyranosyl residue attached at position 3. It has been found in Daphnia pulex and exhibits cytotoxic activity.


A nitroalkane that is propane substituted at C-1 by a nitro group.


3,5-dinitro-4-hydroxyphenylpyruvic acid

A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 3,5-dinitro-4-hydroxyphenyl group.


A 6-methoxy-3-methyl-2-all-trans-polyprenylhydroquinone in which the polyprenyl component is specified as all-trans-nonaprenyl.


A secondary alcohol that is tridecane substituted by a hydroxy group at position 2.


A fatty amide comprising nonadecanamide having tetradecyl, oxo and amino substituents at the 2-, 4- and 5-positions respectively.


A ceramide 1-phosphate that is the N-docosanoyl derivative of sphingosine.


L-alpha-phenylglycine

The S stereoisomer of alpha-phenylglycine.


quercetin 5,7,3',4'-tetramethyl ether

A tetramethoxyflavone that is  the 5,7,3',4'-tetramethy-derivative of quercetin.


hydrogentellurite

A monovalent inorganic anion obtained by removal of a proton from H2TeO3


A 2-methoxy-6-all-trans-polyprenylhydroquinone in which the polyprenyl component is specified as all-trans-nonaprenyl.


A polyprenylhydroquinone in which the polyprenyl substituent is at C-2 with an additional methoxy group present at C-6.


A polyprenylhydroquinone in which the polyprenyl substituent is hexaprenyl at C-2; an additional methoxy group is also present at C-6.


A 2-methoxy-6-all-trans-polyprenylhydroquinone in which the polyprenyl component is specified as all-trans-heptaprenyl.


name: epilepsy, idiopathic generalized, susceptibility to, 11

description: An inherited susceptibility or predisposition to developing epilepsy, idiopathic generalized, in which the cause of the disease is a mutation in the CLCN2 gene.


name: epilepsy, juvenile absence, susceptibility to


name: epilepsy, juvenile absence, susceptibility to, 1


An alkapentaene that is henicos-1-ene with 4 cis double bonds at positions 6,9,12 and 15.


A glycosylglycerol derivative that is 2-O-alpha-D-glucopyranosyl-beta-D-galactofuranose in which the anomeric hydroxy group has been converted into its 2,3-dihydroxypropyl glycoside.


A C-glycosyl compound that is luteolin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively.


The dihydrate of a tris(1,10-phenanthroline)ruthenium(2+) dichloride salt.


A CDP-3,6-dideoxy-D-mannose in which the anomeric centre of the sugar component has alpha-configuration.


A CDP-sugar in which the sugar component is 3,6-dideoxy-D-mannose.


A ceramide that is the N-docosanoyl derivative of 4-hydroxyeicosasphinganine.


name: 2-[[cyclohexyl(oxo)methyl]amino]-1,3-benzothiazole-6-carboxylic acid methyl ester


L-methionine 2-naphthylamide

An L-methionine derivative that is the amide obtained by formal condensation of the carboxy group of L-methionine with the amino group of 2-naphthylamine.


A methionine derivative that is the amide obtained by formal condensation of the carboxy group of methionine with the amino group of 2-naphthylamine.


D-methionine 2-naphthylamide

A D-methionine derivative that is the amide obtained by formal condensation of the carboxy group of D-methionine with the amino group of 2-naphthylamine.


Major species at pH 7.3.


A glycol that is cumene carrying two hydroxy substituents at positions 1 and 2


An amino disaccharide consisting of a beta-D-galactopyranose residue and two 2-acetamido-2-deoxy-beta-D-glucopyranose residues joined in sequence by (1->4) glycosidic bonds.


The stable isotope of beryllium with relative atomic mass 9.012182, 100 atom percent natural abundance and nuclear spin 3/2.


(24S)-24-hydroxycholesterol 3-hexanoate

A sterol ester that is the 3-hexanoyl derivative of (24S)-24-hydroxycholesterol.


hexanoate ester

Any fatty acid ester where the carboxylic acid component is hexanoic (also known as caproic) acid.


A cholesteryl 6-O-acyl-beta-D-galactoside having hexanoyl as the 6-O-acyl group.


butyl hexanoate

A hexanoate ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with butan-1-ol. It is a volatile compound found in apples and peaches.


taiwanschirin D

An  organic heterotetracyclic compound isolated from the stems of Kadsura matsudai.


hydrocortisone caproate

The 21-O-hexanoyl derivative of hydrocortisone.


propyl hexanoate

A hexanoate ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with  propan-1-ol.


PESCAPREIN XXIX

A resin glycoside that is the pentasaccharide derivative of jalapinolic acid. Isolated from the aerial parts of Ipomoea pes-caprae, it has been found to exhibit potential inhibitory effect against multidrug resistance in the human breast cancer cell line.


isobutyl hexanoate

A hexanoate ester resulting from the formal condensation of hexanoic acid (caproic acid) with isobutanol.


hexyl hexanoate

A hexanoate ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with hexan-1-ol. It is a constituent found in passion fruit, apples, strawberries and wine.


3-methylbutyl hexanoate

A fatty acid ester obtained by the formal condensation of the carboxy group of hexanoic acid (caproic acid) with the alcoholic hydroxy group of 3-methylbutan-1-ol (isoamylol).


ROHITUKINE

A member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol.


(14R)-14-hydroxypentadecanoic acid

An (omega-1)-hydroxy fatty acid that is pentadecanoic acid in which the 14-pro-R hydrogen is replaced by a hydroxy group.


adamanzane

Any one of a class of organic heteropolycyclic compounds having a polycyclic cage structure containing four nitrogen atoms linked by carbons, the nitrogens occupying the vertices of a tetrahedron or similar cyclic structure, with potentially four faces and six edges, with carbon chains running approximately along the edges.


penimepicycline

A penicillinate salt obtained by combining equimolar amounts of  phenoxymethylpenicillin and pipacycline.


A 2-(3,4-dihydroxyphenyl)-2,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one that has (R) configuration.


3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al with S-configuration at C-24.


A glycodiosylceramide consisting of a beta-D-galactosyl-(1->4)-beta-D-glucosyl moiety attached to the primary hydroxyl group of N-acylated C20 sphingosine.


OXAZOLE

A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.


name: N,N-diethylcarbamodithioic acid [2-(2-methyl-1H-indol-3-yl)-2-oxoethyl] ester


malaoxon

A racemate comprising equimolar amounts of (R) and (S)-malaoxon. It is the active insecticide of the proinsecticide malathion.


A methyl-branched fatty acyl-CoA in which the unspecified acyl group carries a methyl substituent at position 2.


A (2S)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2S)-2-methylpentadecanoic acid.


A (2S)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2S)-2-methylbutanoic acid.


A (2R)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2R)-2-methyltetradecanoic acid.


A (2S)-2-methylacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (2S)-2-methyltetradecanoic acid.


A cysteine derivative in which the thiol hydrogen of cysteine is replaced by a 5-acetamido-2-hydroxyphenyl group.


4-O-dimethylallyl-L-tyrosine zwitterion

An amino acid zwitterion obtained by transfer of a proton from the amino to the carboxy group of 4-O-dimethylallyl-L-tyrosine; major species at pH 7.3.


dihydroconiferyl alcohol

A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.


ATTO 565 para-isomer(1+)

The para-isomer of ATTO 565 cation.


A mimotope of the pyruvate dehydrogenase E2 component (PDC-E2) comprising a [(2E)-3-(4-chlorophenyl)prop-2-enoyl]-group linked to the lipoated PDC-E2 core dodecapeptide (DKATIGFEVQEE) at N-6 of lysine.


naphthalenetetrol

A hydroxynaphthalene carrying four hydroxy substituents.


A naphthalenetetrol that is naphthalene substituted by hydroxy groups at positions 1, 3, 6 and 8.


A naphthalenetetrol that is naphthalene which is substituted by hydroxy groups at postions 1, 2, 4, and 8. Also known as naphthalene-1,3,4,5-tetrol.


A steroid glucosiduronic acid that is chenodeoxycholic acid  having a single beta-D-glucuronic acid residue attached at position 3.


A hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK).


EMERICELLAMIDE A

An emericellamide derived from N-[(2R,3R,4S)-3-hydroxy-2,4-dimethyldecanoyl]glycyl-L-valyl-L-leucyl-L-alanyl-L-alanine by the formal intramolecular condensation of the alcoholic hydroxy group with the C-terminal carboxylic acid group.


name: 4-chloro-3-[[2-(4-methyl-1-piperidinyl)-1-oxoethyl]amino]benzoic acid methyl ester


The 9H-tautomer of purine.


benzimidazole

A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings.


A benzothiophene in which the benzene ring is fused to the thiophene ring across positions 3 and 4.


indole

Either of two isomeric forms comprising a benzene ring fused to a pyrrole ring.


The 3H-tautomer of purine.


A simplest member of the class of chromene in which the heterocyclic pyran ring has a double bond between positions 2 and 3.


The 1H-tautomer of purine.


The 7H-tautomer of purine.


isochromenylium

An organic cation that is isochromene with a protonated oxygen.


purine

A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines.


A simplest member of the class of chromene in which the heterocyclic pyran ring has a double bond between positions 3 and 4.


BENZO[C]ISOXAZOLE

A benzoxazole in which the benzene ring is fused to a 1,2-oxazole ring across positions 3 and 4.


name: 5-methoxy-3-methyl-2-benzofurancarboxylic acid (3-cyano-4-imino-2-oxopentyl) ester


A long-chain primary fatty alcohol that is  nonadecan-1-ol substituted by a methyl group at position 18.


long-chain primary fatty alcohol

A long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.


A long-chain primary fatty alcohol that is  henicosan-1-ol substituted by a methyl group at position 20.


A long-chain primary fatty alcohol that is tridecan-1-ol substituted a methyl group at position 12.


ISOSTEARYL ALCOHOL

A long-chain primary fatty alcohol that is heptadecan-1-ol substituted by a hydroxy group at position 1 and a methyl group at position 16.


A long-chain primary fatty alcohol that is octadecan-1-ol (stearyl alcohol) substituted by a methyl group at position 16.


A long-chain fatty alcohol that is stearyl alcohol which has been dehydrogenated to introduce a cis double bond between positions 13 and 14.


A long chain fatty primary alcohol that is octadecanol containing three double bonds located at positions 9, 12 and 15.


A long-chain primary fatty alcohol that is henicosane in which a hydrogen attached to one of the terminal carbons is replaced by a hydroxy group. It has been isolated from the aerial parts of Siegesbeckia orientalis and from an Italian bread wheat variety, Pegaso, and its 11 near-isogenic lines.


A long-chain primary fatty alcohol that is tridecane substituted by a hydroxy group at position 1.


A long-chain fatty alcohol that is dodecan-1-ol bearing a methyl substituent at position 11.


A long-chain primary fatty alcohol that is hexadecan-1-ol substituted by a methyl group at position 14.


MYRISTYL ALCOHOL

A long-chain fatty alcohol that is tetradecane substituted by a hydroxy group at position 1.


A long-chain fatty alcohol that is hexadecan-1-ol bearing a methyl substituent at position 15.


cetyl alcohol

A long-chain primary fatty alcohol that is hexadecane substituted by a hydroxy group at position 1.


A long-chain primary fatty alcohol that is icosan-1-ol substituted by a methyl group at position 18.


A long-chain fatty alcohol that is (13Z)-docosene in which one of the terminal methyl hydrogens at position 1 is replaced by a hydroxy group


A long-chain primary fatty alcohol that is docosan-1-ol substituted by a methyl group at position 20.


A long-chain primary fatty alcohol that is nonadecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group.


A long-chain primary fatty alcohol that is  pentadecan-1-ol substituted by a methyl group at position 14.


A long-chain primary fatty alcohol that is (5Z,8Z,11Z,14Z)-icosatetraene in which one of the methyl hydrogens at position 1 is replaced by a hydroxy group.


isopersin

A long-chain primary fatty alcohol that is henicosan-1-ol which carries an acetoxy group at position 2, keto group at position 4, and two double bonds at positions 12 and 15.


OLEYL ALCOHOL

A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).


CETOSTEARYL ALCOHOL

A long-chain primary fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of 18 carbon atoms.


A long-chain primary fatty alcohol that is icosane in which one of the terminal methyl hydrogens is replaced by a hydroxy group.


A long chain fatty alcohol that is octadecanol containing two double bonds located at positions 9 and 12 (the 9Z,12Z-geoisomer).


A diol that is hexadecane substituted by hydroxy groups at positions 1 and 16.


A long-chain primary fatty alcohol that is (8Z,11Z,14Z)-icosatriene in which one of the methyl hydrogens at position 1 is replaced by a hydroxy group.


(R)-methcathinone

A 2-methylamino-1-phenylpropan-1-one that has (R)-configuration.


A 3-hydroxybutane-1,2,3-tricarboxylic acid which has (2S,3R) configuration.


methylisocitric acid

A tricarboxylic acid that is isocitric acid substituted by a methyl group alpha- to one of the carboxylic acid groups.


A tricarboxylic acid that is butan-2-ol in which a hydrogen from each of positions 2, 3, and 4 has been replaced by carboxy groups.


name: Hirschsprung disease, susceptibility to, 6


A 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine zwitterion in which the phosphatidyl acyl groups are both specified as oleoyl (9Z-octadecenoyl); major species at pH 7.3.


nucleocidin

A nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness.


name: N-[(3-nitrophenyl)methylideneamino]carbamic acid tert-butyl ester


An amino pentasaccharide that is beta-D-Galp-(1->3)-[beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->6)]-D-GalpNAc in which the beta-D-galactosyl group attached by a (1->4) linkage to an acetamidoglucopyranosyl group has glycosylated at its 3-hydroxy group by an alpha-D-galactopyransyl group.


A sulfoxide that is omeprazole in which one of the methyl hydrogens at position 5 on the pyridine ring is substituted by a hydroxy group.


name: 2,4-difluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester


An  oxysterol that is cholesterol substituted  by hydroxy groups at positions 20 and 22 (the 20R,22R-stereoisomer).


name: basal cell carcinoma, susceptibility to, 4


N-methylhippuric acid

An N-acylglycine that is N-methylglycine in which the hydrogen of the amino group is substituted by a benzoyl group.


A member of the class of furans that is furan-3(2H)-one carrying additional ethyl, hydroxy and methyl substituents at positions 2, 4 and 5 respectively. A key aroma compound in soy sauce and fish sauce.


name: N-[3-(1,3-benzodioxol-5-yl)prop-2-enylideneamino]carbamic acid tert-butyl ester


ficusequilignan A

A guaiacyl lignin that is medioresinol in which one of the phenolic hydrogens is replaced by a guaiacylglycerol group. It is found in Arabidopsis thaliana.


(R)-cyclopentolate

The (R)-enantiomer of cyclopentolate.


(S)-cyclopentolate

The (S)-enantiomer of cyclopentolate.


lipid A

The glycolipid moiety of bacterial lipopolysaccharide (R can be either hydrogen or a fatty acyl group).


lipid A (E. coli)

The glycolipid moiety of the lipopolysaccharide produced by E. coli.


PERFLUOROCYCLOBUTANE

A fluorocarbon that is cyclobutane in which all eight hydrogens are replaced by fluorines.


cochinchinone C

A polycyclic cage that is a prenylated-caged xanthone isolated from Cratoxylum cochinchinense and has been shown to exhibit antimalarial and antioxidant activities.


A member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation.


versiconal hydroxyaldehyde form

The tricyclic anthraquinone-hydroxyaldehyde form of versicolorone.


CDP-alpha-D-glucose

A CDP-D-glucose having alpha-configuration at the anomeric centre.


paxanthonin

A member of the class of xanthones that is 9H-xanthen-9-one substituted by a 2,2-dimethyl-4-(prop-1-en-2-yl)cyclopentyl group at position 2, hydroxy groups at positions 1, 3 and 6 and a methoxy group at position 5. It is isolated from the callus of Hypericum perforatum and exhibits antioxidant and antimicrobial activities.


A glycoheptaosylceramide having beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycoheptaosyl component.


polysorbate 20

A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group.


Gly-Gly-Ile zwitterion

A tripeptide zwitterion resulting from the transfer of a proton from the carboxy group to the amino group of Gly-Gly-Ile. Major microspecies at pH 7.3.


cinalukast

2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in the human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma.


antimony-121 atom

The stable isotope of antimony with relative atomic mass 120.903818, 57.2 atom percent natural abundance and nuclear spin 5/2.


antimony-123 atom

The stable isotope of antimony with relative atomic mass 122.904216, 42.8 atom percent natural abundance and nuclear spin 7/2.


cobalt(II)-factor IV

A cobalt-corrinoid heptacarboxylic acid that is produced by Salmonella typhimurium.


deoxyviolacein

A member of the class of oxindoles resulting from formal oxidative coupling between the 3-position of 1,3-dihydro-2H-indol-2-one and the 3-position of 1,3-dihydro-2H-pyrrol-2-one, which is substituted at the 5 position by a 1H-indol-3-yl group, where the newly-formed double bond has E configuration.


name: hypertension, essential, susceptibility to, 4


Any glycosyloxyflavone that consists of a flavonol attached to a rhamnosylglucosyl residue at position 3 via a glycosidic linkage.


name: 2-[[(4-methyl-1-piperazinyl)-sulfanylidenemethyl]amino]benzene-1,4-dicarboxylic acid dimethyl ester


3-(2,3-dihydroxyphenyl)propanoic acid

A monocarboxylic acid that is propionic acid carrying a 2,3-dihydroxyphenyl substituent at C-3; a microbial metabolite of quinoline.


A member of the class of benzaldehydes that is benzaldehyde substituted by a fluoro group at position 3.


flavonol 3-O-D-xylosyl-D-glucoside

A glycosyloxyflavone that consists of flavonol attached to a D-xylosyl-D-glucosyl residue at position 3 via a glycosidic linkage.


(-)-gynuraone

A   chromanone  that is 2,3-dihydro-4H-chromen-4-one substituted by hydroxy groups at positions 3 and 5 and a methyl group at position 2 (the 2R,3R stereoisomer). Isolated form the endophytic fungus Microdiplodia species, it exhibits antibacterial activity.


TERNSTROSIDE C

A beta-D-glucoside with 2-(3,4-dihydroxyphenyl)ethoxy residue at the anomeric position and a [(3,4-dihydroxyphenyl)acetyl]oxy residue at position 3. Isolated from Ternstroemia japonica, it exhibits antioxidant activity.


fatty acid 16:2

Any polyunsaturated fatty acid containing 16 carbons and 2 double bonds.


A chlorocatechol that is catechol in which the hydrogen adjacent to one of the hydroxy groups is replaced by a chlorine.


C8 beta-D-glycosyl N-acylsphingosine

A glycosylceramide in which the ceramide N-acyl group has eight carbons.


C8 beta-D-galactosyl N-acylsphingosine

A D-galactosyl-N-acylsphingosine in which the glycosidic bond has beta-configuration and the ceramide N-acyl group is specified as octanoyl.


C8 beta-D-glucosyl N-acylsphingosine

A beta-D-glucosylceramide in which the ceramide N-acyl group is specified as octanoyl.


astressin

A 30-membered homodetic cyclic peptide comprising the sequence D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 cyclised by an amide bridge, formed by condensation of the side-chain carboxy group of the Glu residue at position 19 and the side-chain amino group of the Lys residue at position 22.


name: 4-[[2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]-1-oxoethyl]amino]benzoic acid ethyl ester


(R)-beta-alanopine

The N-(2-carboxyethyl) derivative of L-alanine.


tetramine

Any polyamine that contains four amino groups.


An optically active tetramine epitope consisting of three separate amino substituents attached to a central carbon.


A 4-O-[(E)-2-methyl-2-butenoyl]ascaroside derived from (2E,8R)-8-hydroxynon-2-enoic acid. It is a metabolite of the nematode Caenorhabditis elegans.


spiramide

An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.


A member of the class of N-acetylneuraminic acids that is alpha-neuraminic acid which has acetylated on N-5 and O-9.


acrovestone

A polyphenol that is isolated from Acronychia pedunculata and exhibits moderate antioxidant and antityrosinase activities.


2-heptenoic acid

A heptenoic acid with the double bond at position 2.


(2Z)-3-bromohept-2-enoic acid

A hept-2-enoic acid carrying a bromo- substituent at C-3.


(E)-hept-2-enoic acid

A 2-heptenoic acid having the trans configuration.


cis-2-heptenoic acid

A 2-heptenoic acid having the cis configuration.


A beta-D-galactosyl-(1<->1')-N-acylsphinganine in which the acyl group specified is docosanoyl.


A neutral glycosphingolipid comprising a tetrasaccharide unit, alpha-D-Man-(1->2)-alpha-D-Gal-(1->6)-alpha-D-GlcN-(1->4)-alpha-D-GlcA, attached to a (13Z)-3-hydroxy-2-{[(2S)-2-hydroxytetradecanoyl]amino}icos-13-en-1-yl lipid group.


heparin glucosamine 3-O-sulfate

A sulfated glycosaminoglycan comprising heparin glucosamine that is randomly sulfated at position 3.


A mannotetraose in which the four mannose units are joined by sequential beta-(1->2)-, alpha-(1->2)- and alpha-(1->2)-linkages.