arabidopside D

An arabidopside that is arabidopside B in which the hydrogen of the hydroxy group at position 6 of the beta-D-galactosyl moiety is replaced by an alpha-D-galactosyl group.


(S)-bitolterol

The (S)-enantiomer of bitolterol.


(R)-nisoldipine

A methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate that has R configuration.


diethyl 2-hydroxypentanedioate

A diester obtained by the formal condensation of both the carboxy groups of 2-hydroxyglutaric acid with two molecules of ethanol respectively.


The (1R,2S,1'R,2'S)-diastereoisomer of doxacurium.


allyl octadecyl oxalate

A  diester obtained by the formal condensation of both the carboxy group of oxalic acid with the hydroxy groups of allyl alcohol and  stearyl alcohol respectively. Metabolite observed in cancer metabolism.


A member of the class of  chromenes that is 2H-1-benzopyran-7-ol acetate substituted by methyl groups at positions 2 and 2, an ethyl group at position 4 and a 4-(acetyloxy)phenyl group at position 3 respectively.


A member of the class xanthones which consists of a dihydroxanthone skeleton substituted by a acetyloxy group at position 4, a hydroxy group at position 8, a methyl group at position 6 and a methoxycarbonyl group at position 4a (the 4R,4aS stereoisomer). It is isolated from Penicillium and exhibits potent antitumour activity against both human and murine tumour cell lines.


meso-doxacurium

The (1R,1'S,2S,2'R) isomer of 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium]. It is the meso-isomer which has a trans configuration at the 1 and 2 positions of the tetrahydroisoquinolinium rings.


A member of the class of pyridines that is pyridine substituted by a (2-methylpropoxy)carbonyl and a (2-phenylethoxy)carbonyl group at positions 2 and 6 respectively.


nemadipine-A

A dihydropyridine that is that is 1,4-dihydropyridine which is substituted at positions 2 and 6 by methyl groups, at positions 3 and 5 by ethoxycarbonyl groups, and at position 4 by a pentafluorophenyl group. An L-type calcium channel alpha1-subunit antagonist. When exposed to the microscopic soil nematode Caenorhabditis elegans, nemadipine-A induces a variety of defects including those affecting morphology and egg laying.


(R)-malaoxon

A diethyl 2-[(dimethoxyphosphoryl)thio]succinate that is the R-enantiomer of malaoxon.


dimethyl sebacate

A fatty acid methyl ester that is sebacic acid  in which both carboxy groups are replaced by methoxycarbonyl groups.


(1S,2R,1'S,2'R)-doxacurium chloride

The dichloride salt of (1S,2R,1'S,2'R)-doxacurium.


(R)-nicardipine

The R-enantiomer of nicardipine.


(R)-bitolterol

The (R)-enantiomer of bitolterol.


4-O-feruloyl-D-quinic acid

The 4-O-feruloyl derivative of D-quinic acid.


name: Appendiceal Carcinoid pT0 TNM Finding v7

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Appendiceal carcinoid with no evidence of primary tumor. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT3 TNM Finding v7

description: Melanoma of the conjunctiva with local invasion.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva Clinical TNM Finding v7

description: A clinical finding about one or more characteristics of melanoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system.  The classification applies only to conjunctival melanoma and primary acquired melanosis with atypia.  In general, there should be a histologic evaluation of the tumor.  The clinical assessment of a melanocytic conjunctival tumor is based on inspection, slit-lamp examination, and palpation of the regional lymph nodes.  All conjunctival surfaces should be inspected and photographed (including eversion of the upper eyelid). (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT2d TNM Finding v7

description: Any caruncular, greater than 1 quadrant.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT1c TNM Finding v7

description: Melanoma of the bulbar conjunctiva more than 2 but less than or equal to 3 quadrants.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT2b TNM Finding v7

description: Melanoma of the nonbulbar (palpebral, forniceal, but no caruncular) conjunctiva greater than 1 quadrant.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva Clinical Regional Lymph Nodes TNM Finding v7

description: A clinical finding about one or more characteristics of melanoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.


name: Melanoma of the Conjunctiva cT2c TNM Finding v7

description: Any caruncular, less than or equal to 1 quadrant.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT1d TNM Finding v7

description: Melanoma of the bulbar conjunctiva greater than 3 quadrants.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cM0 TNM Finding v7

description: Melanoma of the conjunctiva without evidence of distant metastasis. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT3d TNM Finding v7

description: Melanoma of the conjunctiva invading a sinus.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT3c TNM Finding v7

description: Melanoma of the conjunctiva invading the orbit.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cN0b (No Biopsy) TNM Finding v7

description: Melanoma of the conjunctiva with no regional lymph node metastasis; biopsy not performed. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT0 TNM Finding v7

description: Melanoma of the conjunctiva with no evidence of a primary tumor. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cNX TNM Finding v7

description: Melanoma of the conjunctiva in which the regional lymph nodes cannot be assessed.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva Clinical Distant Metastasis TNM Finding v7

description: A clinical finding about one or more characteristics of melanoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.


name: Melanoma of the Conjunctiva cTX TNM Finding v7

description: Melanoma of the conjunctiva in which the primary tumor cannot be assessed. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT3b TNM Finding v7

description: Melanoma of the conjunctiva invading the eyelid.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva Clinical Primary Tumor TNM Finding v7

description: A clinical finding about one or more characteristics of melanoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Melanoma of the Conjunctiva cT(is) TNM Finding v7

description: Melanoma confined to the conjunctival epithelium. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cN0a (Biopsy) TNM Finding v7

description: Melanoma of the conjunctiva with no regional lymph node metastasis; biopsy performed. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cM1 TNM Finding v7

description: Melanoma of the conjunctiva with distant metastasis. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT4 TNM Finding v7

description: Melanoma of the conjunctiva invading the central nervous system.  (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cN1 TNM Finding v7

description: Melanoma of the conjunctiva with regional lymph node metastasis. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT1a TNM Finding v7

description: Melanoma of the bulbar conjunctiva less than or equal to 1 quadrant.  Note: Quadrants are defined by clock hour, starting at the limbus (e.g., 6, 9, 12, 3) extending from the central cornea, to and beyond the eyelid margins.  This will bisect the caruncle. (from AJCC 7th Ed.)


name: Melanoma of the Conjunctiva cT1b TNM Finding v7

description: Melanoma of the bulbar conjunctiva more than 1 but less than or equal to 2 quadrants.  (from AJCC 7th Ed.)


name: Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


FLUSULFAMIDE

A sulfonamide resulting from the formal condensation 4-chloro-3-(trifluoromethyl)benzenesulfonic acid with 2-chloro-4-nitroaniline. A fungicide, it is used to control Plasmodiophora brassicae in brassicas and Polymyxa betae in sugarbeet.


An N-glycosylated dialkylglycerophosphoethanolamine in which the dialkylglycerophosphoethanolamine is 1,2-dihexadecyl-sn-glycero-3-phosphoethanolamine and the glycosylating saccharide is the branched nonasaccharide alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc, the GlcNAc residue at the reducing end of which is in the ring-opened form.


Ectopic Meningioma

description: A meningothelial neoplasm that arises from an anatomic site outside the intracranial and intraspinal compartments.


Primary Middle Ear Meningioma

description: A rare extracranial meningioma that arises from the middle ear.


Primary Sinonasal Meningioma

description: A rare extracranial meningioma that arises from the sinonasal tract.


Grade 3 Seizure, CTCAE

description: New onset seizures (partial or generalized); multiple seizures despite medical intervention


name: Melanoma of the Ciliary Body and Choroid pT2d TNM Finding v7

description: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. (from AJCC 7th Ed.)


name: Melanoma of the Ciliary Body and Choroid pT2 TNM Finding v7

description: Tumor size category 2. (from AJCC 7th Ed.)


name: Melanoma of the Ciliary Body and Choroid pT2b TNM Finding v7

description: Tumor size category 2 with ciliary body involvement. (from AJCC 7th Ed.)


name: Melanoma of the Ciliary Body and Choroid pT2a TNM Finding v7

description: Tumor size category 2 without ciliary body involvement and extraocular extension. (from AJCC 7th Ed.)


name: Melanoma of the Ciliary Body and Choroid pT2c TNM Finding v7

description: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. (from AJCC 7th Ed.)


description: Evidence of alcohol abuse with intoxication delirium.


manganese(II) sulfate dihydrate

A hydrate that is the dihydrate form of manganese(II) sulfate.


name: Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Vulvar Cancer pN1b TNM Finding v7

description: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater. (from AJCC 7th Ed.)


name: Grade 2 Hepatic Artery Intra-Operative Injury, CTCAE


FRUTICOSIDE D

A steroid saponin that is 4-methylergosta-7,24(28)-dien-21-oic acid attached to an acetyloxy group at position 2, and a alpha-L-quinovopyranosyloxy group at position 3 (the 2alpha,3beta,4alpha,5alpha stereoisomer). It has been isolated from the roots of Breynia fruticosa.


A glycohexaosylceramide having alpha-D-GalNAc-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc as the glycohexaosyl component.


prosolanapyrone II

A prosolanapyrone that is prosolanapyrone I in which one of the hydrogens of the methyl substituent at position 3 of the pyrone ring is substituted by a hydroxy group.


Grade 2 Trismus, CTCAE

description: Decreased ROM requiring small bites, soft foods or purees


A 1-(phosphoribosyl)imidazolecarboxamide that is the 5-(5-phospho-beta-D-ribosylamino)methylidene derivative of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.


A 1-(phosphoribosyl)imidazole that is 5-aminoimidazole in which the proton at position 1 has been replaced by a 5-phospho-beta-D-ribofuranosyl group.


A 1-(phosphoribosyl)imidazole having the phospho group at the 5'-position and a carboxyamino group at the 5-position on the imidazole ring.


name: Hodgkin's disease mixed cellularity stage II subdiaphragmatic


name: Ann Arbor Stage II Mixed Cellularity Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Hodgkin's disease mixed cellularity stage II supradiaphragmatic


A sialotetraosylceramide consisting of a linear pentasaccharide made up from one lactamized sialyl residue, two galactose residues, one N-acetyl-6-sulfoglucosamine residue and one glucose residue, which at the reducing end is attached to a d18:1/18:0 ceramide moiety via a beta-linkage.


PLATENCIN A4

A polycyclic cage that is the 3-hydroxy derivative of platencin. It is isolated from Streptomyces platensis.


remazole black-GR

A bis(azo) compound with two aryldiazenyl moieties placed at positions 2 and 7 of a multi-substituted naphthalene.


Childhood Sympathetic Paraganglioma

description: A sympathetic paraganglioma that occurs during childhood.


Childhood Paraganglioma

description: A paraganglioma that occurs during childhood.


Childhood Parasympathetic Paraganglioma

description: A parasympathetic paraganglioma that occurs during childhood.


Childhood Composite Paraganglioma

description: A composite paraganglioma that occurs during childhood.


Prostate Cancer pM1b TNM Finding v8

description: Prostate cancer with metastasis to bone(s). (from AJCC 8th Ed.)


name: Grade 1 Throat and Pharynx and Larynx Pain, CTCAE


Cervical Cancer pT2a1 TNM Finding v8

description: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. (from AJCC 8th Ed.)


A glycopentaosylceramide having N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucose as the pentasaccharide component.


Cervical Cancer pN2mi TNM Finding v9

description: Cervical cancer with regional lymph node metastasis (measuring more than 0.2 mm but equal or less than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. (from AJCC 9th Ed.)


Cervical Cancer pN1 TNM Finding v9

description: Cervical cancer with regional lymph node metastasis to pelvic lymph nodes only. (from AJCC 9th Ed.)


Cervical Cancer pN2a TNM Finding v9

description: Cervical cancer with regional lymph node metastasis (measuring more than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. (from AJCC 9th Ed.)


Cervical Cancer pN1mi TNM Finding v9

description: Cervical cancer with regional lymph node metastasis (measuring more than 0.2 mm but equal or less than 2.0 mm in diameter) to pelvic lymph nodes. (from AJCC 9th Ed.)


Cervical Cancer pN2 TNM Finding v9

description: Cervical cancer with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes. (from AJCC 9th Ed.)


Cervical Cancer pN1a TNM Finding v9

description: Cervical cancer with regional lymph node metastasis (measuring more than 2.0 mm in diameter) to pelvic lymph nodes. (from AJCC 9th Ed.)


chromanol

Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.


A member of the class of chromanols that is (+)-gamma-tocopherol bearing an additional hydroxy substituent at position 13'.


(S,R,S)-alpha-tocopherol

The (S,R,S)-stereoisomer of alpha-tocopherol.


(R,R,S)-alpha-tocopherol

The (R,R,S)-stereoisomer of alpha-tocopherol.


didesmethyl tocotrienol

A tocotrienol that is chroman-6-ol substituted by a farnesyl chain at position 2.


desmethyl tocotrienol

A tocotrienol that is chroman-6-ol substituted by a methyl group at position 2 and a farnesyl group at position 2.


A tocopherol in which the chroman-6-ol core is substituted by a methyl group at position 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.


(S,S,R)-alpha-tocopherol

The (S,S,R)-stereoisomer of alpha-tocopherol.


(R,S,R)-alpha-tocopherol

The (R,S,R)-stereoisomer of alpha-tocopherol.


tocol

A chromanol with a chroman-6-ol skeleton that is substituted at position 2 by a saturated or triply-unsaturated hydrocarbon chain consisting of three isoprenoid units.


A member of the class of chromanols that is (+)-alpha-tocopherol bearing an additional hydroxy substituent at position 13'.


A chromanol that is chromane in which the hydrogen at position 6 is replaced by a hydroxy group.


beta-tocopherol

A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 5 and 8. While it is found in low concentrations in many vegetable oils, only cottonseed oil contains significant amounts.


(S,S,S)-alpha-tocopherol

The (S,S,S)-stereoisomer of alpha-tocopherol.


(S,R,R)-alpha-tocopherol

The (S,R,R)-stereoisomer of alpha-tocopherol.


alpha-tocopherol

A tocopherol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a 4,8,12-trimethyltridecyl group at position 2.


(R,S,S)-alpha-tocopherol

The (R,S,S)-stereoisomer of alpha-tocopherol.


GAMMA-TOCOTRIENOL

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers.


Temporal Lobe Ependymal Tumor

description: A finding indicating the presence of an ependymal tumor in the temporal lobe of the brain.


arachidonoyl-CoA

An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of arachidononic acid.


name: Mismatch Repair-Deficient Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by mismatch repair (MMR) deficiency caused by inactivating methylation or less frequently mutation of an MMR gene (MLH1, PMS2, MSH2, or MSH6).


A beta-D-glucosylceramide obtained by formal condensation of the carboxy group of docosanoic acid with the amino group of beta-D-glucosyl-(1<->1')-(4E,14Z)-sphingadienine.


C-14 demethylated eburicol


RIBOSE (PYRANOSE)

A D-ribopyranose with a beta-configuration at the anomeric position.


ribopyranose

The pyranose form of ribose.


L-ribopyranose

The L-stereoisomer of ribopyranose.


beta-L-ribopyranose

A L-ribopyranose with a beta-configuration at the anomeric position.


alpha-L-ribopyranose

A L-ribopyranose with an alpha-configuration at the anomeric position.


D-ribopyranose

A D-ribose and the D-enantiomer of ribopyranose.


alpha-D-ribopyranose

A D-ribopyranose with an alpha-configuration at the anomeric position.


ethyl 3-nonenoate

A fatty acid ethyl ester obtained by the formal condensation of 3-nonenoic acid with ethanol.


A secondary fatty alcohol that is nonadecane substituted by a hydroxy group at position 9.


Grade 2 Kidney Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


A 4-dodecyl-2,6-dimethylmorpholine in which the methyl substituents are in a cis relationship to each other.


(4S)-4-hydroxy-4-methyl-L-glutamic acid

A 4-hydroxy-4-methyl-L-glutamic acid that has S-configuration.


Stent restenosis

description: Fifty percent or greater stenosis within an existing stent. (ACC)


Uterine Corpus Neuroendocrine Tumor G1

description: A very rare, well-differentiated, low-grade neuroendocrine neoplasm that arises from the uterine corpus.


Stress ulcer

description: An ulcer due to stress.


Orbit Solitary Fibrous Tumor

description: A solitary fibrous tumor that arises from the orbit. Most of these tumors are benign.


name: (4S)-4-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid [(3R)-1-azabicyclo[2.2.2]octan-3-yl] ester


abacavir 5'-carboxylic acid

A monocarboxylic acid oxidation product of abacavir, in which the C-5' hydroxymethyl group has been oxidised to a carboxy group. One of the two major metabolites of abacavir in humans (the other is the 5'-glucuronide, CHEBI:64189).


lauryl acrylate

An acrylate ester obtained by the formal condensation of the hydroxy group of dodecan-1-ol with the carboxy group of acrylic acid.


chlorphenesin carbamate

The carbamate ester of the primary hydroxy group of chlorphenesin. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.


Prostate Cancer pT3a TNM Finding v7

description: Prostate cancer with extraprostatic extension or microscopic invasion of bladder neck.  Positive surgical margin should be indicated by an R1 descriptor (residual microscopic disease). (from AJCC 7th Ed.)


A glycopeptidolipid antigen from clinically prominent members of the Mycobacterium avium serocomplex.


name: Cerebral Infarction due to Embolism of Right Cerebellar Artery

description: Evidence of cerebral infarction due to an embolism of the right cerebellar artery.


Systemic Vascular Resistance

description: The resistance to blood flow offered by all systemic vasculature, excluding pulmonary vasculature. The major determinant of SVR is arteriolar tone, but blood viscosity and vascular capacitance are also contributing factors.


connective tissue

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.


adipose tissue

description: Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.


Malignant neoplasm of exocervix

description: A malignant neoplasm that affects the exocervix.


name: Grade 5 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


2-nitroguanidine derivative

Any nitroguanidine derivative resulting from the replacement of one or more hydrogens of 2-nitroguanidine by an organyl group.


MESORIDAZINE BESYLATE

The benzenesulfonate salt of mesoridazine prepared using equimolar amounts of mesoridazine and benzenesulfonic acid.


name: Unknown Primary Tumor pN2b TNM Finding v8

description: Unknown primary tumor with metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Unknown Primary Tumor pN2 TNM Finding v8

description: Unknown primary tumor with metastasis in a single ipsilateral or contralateral cervical lymph node 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral cervical lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). ENE detected on histopathologic examination is designated as ENEmi (microscopic ENE equal or less than 2 mm) or ENEma (major ENE more than 2 mm).  (from AJCC 8th Ed.)


name: Unknown Primary Tumor pN2c TNM Finding v8

description: Unknown primary tumor with metastases in bilateral or contralateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Unknown Primary Tumor pN2a TNM Finding v8

description: Unknown primary tumor with metastasis in a single ipsilateral or contralateral cervical lymph node 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral cervical lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


A thioadenosine that is adenosine in which the hydroxy group at C-5' is replaced by a 3-aminopropyl group.


METHYLTHIOADENOSINE

Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.


A thioadenosine that is adenosine with the hydroxy group at C-5' substituted with an ethylthio (ethylsulfanyl) group.


omega-hydroxyphylloquinone

A member of the class of phylloquinones obtained by hydroxylation of one of the terminal methyl groups of phylloquinone itself.


A phylloquinone that consists of 1,4-naphthoquinone bearing a phytyl group at position 2.


name: 2-(6-imidazo[2,1-b]thiazolyl)acetic acid (phenylmethyl) ester


A 3-(2-isocyanovinyl)indole in which the double bond of the isocyanovinyl group has Z (cis-) configuration. An antibacterial agent isolated from a species of Pseudomonas.


An isocyanide that is indole which is substituted at position 3 by a 2-isocyanovinyl group. The Z isomer has been isolated from a Pseudomonas species and has antibacterial properties.


A 3-(2-isocyanovinyl)indole in which the double bond of the isocyanovinyl group has E (trans-) configuration.


name: Grade 5 Superior Vena Cava Vein Injury, CTCAE


A carboxamidine heterocycle which is obtained by formal condensation of 4-amino-L-allothreonine with acetic acid.


carboxamidine

Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom.


MK 351A

A member of the class of formamidines that is lisinopril in which the primary amino group is substituted by an {(E)-[(4-hydroxyphenyl)imino]methyl}amino group. It is a potent ACE inhibitor.


tipiracil

A member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer.


TRIFLUMIZOLE

A carboxamidine resulting from the formal condensation of the amino group of 4-chloro-2-(trifluoromethyl)aniline with the oxygen of the acetyl group of N-(propoxyacetyl)imidazole. A sterol demethylation inhibitor, it is used as a fungicide for the control of powdery mildew, scab and other diseases on a variety of crops.


An isoquinoline that is 3,4-dihydroisoquinoline bearing amidino and hydroxy substituent at positions 2 and 4 respectively.


A benzamide obtained by formal condensation of the carboxy group of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid with the amino group of N-methoxymethanimidamide.


(R)-fluxametamide

A 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(methoxyamino)methylidene]-2-methylbenzamide that is the (R)-enantiomer of fluxametamide.


FRADAFIBAN

A pyrrolidinone that is pyrrolidin-2-one which is substituted at positions 3 and 5 by carboxymethyl and hydroxymethyl groups, respectively, and in which the hydrogen of the resulting alcoholic hydroxy group is replaced by a 4'-carbamimidoylbiphenyl-4-yl group (the S,S-diastereoisomer). A figrinogen receptor antagonist.


formamidines

Amidines with the general formula R(1)N=CHNR(2)R(3) (R(1), R(2), R(3) can be H).


A-234 nerve agent

A carboxamidine that is N,N-diethylethanimidamide in which the hydrogen attached to the imino nitrogen has been replaced by a fluoro(ethoxy)phosphoryl group. A toxic nerve agent developed by the former Soviet Union.


A-232 nerve agent

A carboxamidine that is N,N-diethylethanimidamide in which the hydrogen attached to the imino nitrogen has been replaced by a fluoro(methoxy)phosphoryl group. A toxic nerve agent developed by the former Soviet Union.


dabigatran etexilate

An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-{N'-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amino group of ethyl N-pyridin-2-yl-beta-alaninate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.


ectoine

A carboxamidine heterocycle obtained by formal condensation of (2S)-2,4-diaminobutanoic acid with acetic acid.


A substituted diphenylfuran in which two N-ethylamidino substituents are located at the two para-positions on the phenyl rings.


CYFLUFENAMID

A member of the class of (trifluoromethyl)benzenes that is 2,3-difluoro-6-(trifluoromethyl)benzenecarboxamidine in which the hydrogen attached to the imino nitrogen is replaced by a cyclopropylmethoxy group while one of the hydrogens attached to the other nitrogen is replaced by a phenylacetyl group. It is used as a fungicide for the control of powdery mildew in cereal crops as well as in apple and pear orchards.


diminazene

A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.


L-indospicine

An  alpha-amino acid that is 2,7-diaminoheptanoic acid substituted by a imino group at position 7 (the 2S stereoisomer).


formamidine

The smallest member of the class of carboxamidines being formic acid with the O and OH groups from the carboxy function replaced by NH and NH2 groups respectively. The parent of the class of formamidines.


A-230 nerve agent

A carboxamidine that is N,N-diethylethanimidamide in which the hydrogen attached to the imino nitrogen has been replaced by a fluoro(methyl)phosphoryl group. A toxic nerve agent developed by the former Soviet Union.


A pyrrolopyrimidine that is 7-deazaguanine bearing a carboxamidine substituent at the 7 position.


acetamiprid

A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group.


(S)-fluxametamide

A 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(methoxyamino)methylidene]-2-methylbenzamide that is the (S)-enantiomer of fluxametamide.


Anal Cancer pM1 TNM Finding v6 and v7

description: Anal cancer with distant metastasis. (from AJCC 6th and 7th Eds.)


Anal Cancer Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of anal cancer, following the rules of the TNM AJCC v7 classification system.


Anal Cancer pN2 TNM Finding v6 and v7

description: Anal cancer with metastasis in unilateral internal iliac and/or inguinal lymph node(s). (from AJCC 6th and 7th Eds.)


Anal Cancer pN0 TNM Finding v6 and v7

description: Anal cancer with no evidence of metastasis to regional lymph nodes. (from AJCC 6th and 7th Eds.)


name: Anal Cancer Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of anal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Anal Cancer Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of anal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.


name: Anal Cancer Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of anal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for anal cancer. (from AJCC 7th Ed.)


Anal Cancer pN3 TNM Finding v6 and v7

description: Anal cancer with metastasis in perirectal and inguinal lymph nodes and/or bilateral internal iliac and/or inguinal lymph nodes. (from AJCC 6th and 7th Eds.)


Anal Cancer pN1 TNM Finding v6 and v7

description: Anal cancer with metastasis in perirectal lymph node(s). (from AJCC 6th and 7th Eds.)


Anal Cancer pNX TNM Finding v6 and v7

description: Anal cancer in which the regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.)


name: Type 2 Diabetes Mellitus with Diabetic Macular Edema, Resolved following Treatment, Left Eye

description: Evidence of type 2 diabetes mellitus with diabetic macular edema which is resolved following treatment in the left eye.


CARANINE

An indolizidine alkaloid that is  galanthan substituted by analpha-hydroxy group at position 1 and a methylenedioxy group across position 9 and 10. An alkaloid commonly found in the members of the family amaryllidaceae.


name: Perihilar Bile Duct Cancer pNX TNM Finding v7

description: Perihilar bile duct cancer in which the regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of perihilar bile duct cancer, following the rules of the TNM AJCC v7 classification system.  The pathologic staging is based on examination of the resected specimen and/or biopsies sufficient to document the greatest extent of the disease. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pN2 TNM Finding v7

description: Perihilar bile duct cancer with metastasis to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pT1 TNM Finding v7

description: Perihilar bile duct cancer with tumor confined to the bile duct, with extension up to the muscle layer or fibrous tissue. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of perihilar bile duct cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.


name: Perihilar Bile Duct Cancer pTX TNM Finding v7

description: Perihilar bile duct cancer in which the primary tumor cannot be assessed. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pT4 TNM Finding v7

description: Perihilar bile duct cancer with tumor invading the main portal vein or its branches bilaterally; or the common hepatic artery; or the second-order biliary radicals bilaterally; or unilateral second-order biliary radicals with contralateral portal vein or hepatic artery involvement. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of perihilar bile duct cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Perihilar Bile Duct Cancer pT2a TNM Finding v7

description: Perihilar bile duct cancer with tumor invading beyond the wall of the bile duct to surrounding adipose tissue. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of perihilar bile duct cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for perihilar bile duct cancer.


name: Perihilar Bile Duct Cancer pN1 TNM Finding v7

description: Perihilar bile duct cancer with regional lymph node metastasis (including nodes along the cystic duct, common bile duct, hepatic artery, and portal vein). (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pT2b TNM Finding v7

description: Perihilar bile duct cancer with tumor invading adjacent hepatic parenchyma. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pT3 TNM Finding v7

description: Perihilar bile duct cancer with tumor invading unilateral branches of the portal vein or hepatic artery. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pT2 TNM Finding v7

description: Perihilar bile duct cancer with tumor invading beyond the wall of the bile duct to surrounding adipose tissue or tumor invading adjacent hepatic parenchyma. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pM1 TNM Finding v7

description: Perihilar bile duct cancer with distant metastasis. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pTis TNM Finding v7

description: Perihilar bile duct cancer with a finding of carcinoma in situ. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pN0 TNM Finding v7

description: Perihilar bile duct cancer with no regional lymph node metastasis. (from AJCC 7th Ed.)


name: Perihilar Bile Duct Cancer pT0 TNM Finding v7

description: Perihilar bile duct cancer with no evidence of primary tumor. (from AJCC 7th Ed.)


Pericardial anomaly

description: Any abnormality involving the pericardium.


1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion in which the acyl group at position 1 is unspecified while that at position 2 is specified as arachidonoyl


A phosphatidylethanolamine 37:5 zwitterion in which the acyl groups at positions 1 and 2 are specified as 10Z-heptadecenoyl and arachidonoyl respectively.


Grade 1 Wrist Fracture, CTCAE

description: Mild; non-operative intervention indicated


name: Grade 5 Anus Stricture or Stenosis, CTCAE


yanuthone E

A class I yanuthone that is 22-deacetylyanuthone A in which the primary alcohol has been esterified by condensation with one of the carboxy groups of 3-hydroxy-3-methylglutaric acid.


Grade 3 Erythroderma, CTCAE

description: Erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL


Erythroderma, CTCAE

description: A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.


Grade 4 Erythroderma, CTCAE

description: Erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated


Grade 2 Erythroderma, CTCAE

description: Erythema covering >90% BSA without associated symptoms; limiting instrumental ADL


Grade 5 Erythroderma, CTCAE

description: Death


Genital Human Papillomavirus Infection

description: Infection of the genitalia by human papillomavirus.


A fatty alcohol that is decan-1-ol in which one of the hydrogens at position 9 has been replaced by a methyl group.


Kidney Tumor, Middle Section

description: A tumor located in the middle section of the kidney.


Reiter's Disease, Vertebrae

description: Evidence of Reiter's disease in the vertebrae.


Iatrogenic Hypoparathyroidism

description: Hypoparathyroidism resulting from medical treatment or intervention.


Acquired Hypoparathyroidism

description: Hypoparathyroidism, the cause of which is not present at birth.


Hypoparathyroidism, Autosomal Recessive

description: Hypoparathyroidism associated with homozygous mutation(s) in the PTH gene, which encodes parathyroid hormone, or in the GCM2 gene, which encodes chorion-specific transcription factor GCMb.


Transient neonatal hypoparathyroidism

description: A disorder of decreased production of parathyroid hormone by the parathyroid gland in a newborn. It is due to maternal hyperparathyroidism. It may be characterized by hypocalcemic seizures in the first weeks of life.


Primary hypoparathyroidism

description: Abnormally low levels of parathyroid hormone due to a disorder originating within the parathyroid glands.


Untreated Childhood Pineoblastoma

description: A finding of childhood pineoblastoma that has not been treated.


name: Acute Extensive Anterior Wall Myocardial Infarction by ECG Finding

description: An electrocardiographic finding of pathologic Q waves with accompanying ST elevation in leads V1 to V6, I and aVL, which is suggestive of acute myocardial infarction involving the anterior and anterolateral walls of the left ventricle. (CDISC)


name: Grade 4 Fibrosis-Deep Connective Tissue, CTCAE


An alkane that is decane which is substituted by a methyl group at positions 2 and 9.


That one of the three tautomers of arsole that has the double bonds at positions 1 and 3.


A mannosylinositol phosphorylceramide compound having a tetracosanoyl group amide-linked to a C20 phytosphingosine base, with hydroxylation at C-2 and C-3 of the C24 very-long-chain fatty acid.


Circumscribed storiform collagenoma

description: A benign skin tumor characterized as a small, dome-shaped dermal nodule composed of fibroblasts in a dense collagenous background with storiform organization.  Rarely, multiple lesions can occur in connection with Cowden's disease.


Senile nevus

description: A benign skin lesion consisting of a cluster of capillaries at the surface of the skin, forming a red papular lesion.


chlorobenzophenone

A member of the class of benzophenones that is any substituted benzophenone in which at least one of the substituents is a chlorine.


name: Drug or Chemical Induced Diabetes Mellitus with Proliferative Diabetic Retinopathy with Combined Traction Retinal Detachment and Rhegmatogenous Retinal Detachment, Right Eye

description: Evidence of drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment in the right eye.


Transcript Variant Negative

description: An indication that variant transcripts were not detected in a sample.


A pentol consisting of 1-(hydroxyimino)hexane with five hydroxy substituents placed at positions 2, 3, 4, 5 and 6.


Chief Complaint is Present Monthly

description: The chief complaint is noted to occur at least once per month.


name: graft-versus-host disease, susceptibility to

description: An inherited susceptibility or predisposition to developing graft vs. host disease.


organosilicon compound

An organosilicon compound is a compound containing at least one carbon-silicon bond.


An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/mass spectrometry applications.


A silyl ether that is isopropanol in which the hydroxyl hydrogen is replaced by a trimethylsilyl group.


A silyl ether that is the N,O-bis(trimethylsilyl) derivative of trifluoroacetamide. N,O-bis(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/mass spectrometry applications.


silyl ether

Ethers ROR' where R' has the structure SiR''R'''R''''.


flotufolastat F-18

An (18)F radiopharmaceutical which is used as a radioactive diagnostic agent for positron emission tomography (PET) of prostate-specific membrane antigen positive lesions in men with prostate cancer.


An organosilicon compound that is phenol substituted by a trimethylsilyl group at position 4.


benzyl trimethylsilyl ether

A silyl ether that is benzyl alcohol in which the hydroxyl hydrogen is replaced by a trimethylsilyl group.


SILAFLUOFEN

An organosilicon compound that is dimethylsilane in which one of the hydrogens attached to the silicon is replaced by a 4-ethoxyphenyl group, while the other is replaced by a 3-(4-fluoro-3-phenoxyphenyl)propyl group. It is an insecticide used to control soil-borne insects.


(R)-simeconazole

A 2-(4-fluorophenyl)-1-(1,2,4-triazol-1-yl)-3-(trimethylsilyl)propan-2-ol that is the (R)-enantiomer of simeconazole.


A member of the class of imidazoles that is 1-methylimidazole substituted by bis(trimethylsilyl)amino and trimethylsilyl groups at positions 2 and 5 respectively.


bis(trimethylsilyl)isovanillate

A benzoate ester that is 3-hydroxy-4-methoxybenzoic acid in which the carboxy and phenolic hydrogens are replaced by trimethylsilyl groups.


A polyether that is tetraethylene glycol in which the terminal hydroxy hydrogens are replaced by methyl and trimethylsilyl groups.


A silyl ether that is 2,6-dihydroxypurine carrying three trimethylsilyl substituents at positions O-2, O-6 and N-7.


3-(trimethylsilyl)propionic acid

An organosilicon compound that is propionic acid substituted at position 3 by a trimethylsilyl group. It is used as internal reference in the NMR spectrum nuclear magnetic resonance for aqueous solvents (e.g. D2O).


N-trimethylsilylimidazole

A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a trimethylsilyl group. N-trimethylsilylimidazole is a derivatisation agent used in gas chromatography/mass spectrometry applications.


SIMECONAZOLE

A racemate comprising equal amounts of (R)- and (S)-simeconazole. A broad spectrum biofungicide used to control a range of diseases in particular Rhizoctonia solani Kuhn and Blumeria graminis on rice, fruit, soya and vegetables.


An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a tert-butyldimethylsilyl group.


(S)-simeconazole

A 2-(4-fluorophenyl)-1-(1,2,4-triazol-1-yl)-3-(trimethylsilyl)propan-2-ol that is the (S)-enantiomer of simeconazole.


SILTHIOFAM

A monocarboxylic acid amide obtained by formal condensation of the carboxy group from 4,5-dimethyl-2-(trimethylsilyl)thiophene-3-carboxlic acid with the amino group of allylamine. A fungicide seed dressing for cereals used mainly to control 'take-all'.


(S)-triticonazole

A (5E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1,2,4-triazol-1-ylmethyl)cyclopentanol that is the (S)-enantiomer of triticonazole.


name: Grade 2 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


OTOSENINE

A pyrrolizine alkaloid that is produced by several Jacobaea and Senecio species.


Eye Redness

description: The prominence of the superficial vessels of the sclera or conjunctiva resulting in a red or pink appearance.


name: Prostate Cancer pT3b TNM Finding v6 and v7

description: Prostate cancer with seminal vesicle invasion. (from AJCC 6th and 7th Eds.)


STIGMASTANOL

A 3-hydroxy steroid that is 5alpha-stigmastane which is substituted at the 3beta position by a hydroxy group.


Grade 1 Feeding Intolerance, AE

description: An adverse event in a newborn characterized by mild feeding intolerance (e.g. increased gastric residual volume or abdominal distension); without discomfort; no change in care indicated.


A hexasaccharide derivative in which N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


Elevated AFP-L3

description: A finding indicating that elevated concentrations of alpha-fetoprotein (AFP) fraction L3 (AFP-L3) were detected in a sample. AFP-L3 represents a glycoform variant of AFP that is highly reactive with Lens culinaris-expressed agglutinin (LCA) due to the presence of an extra alpha-(1-6) fucose attached to the N-acetylglucosamine modification present in AFP.


AFP Level Finding

description: A finding that indicates the amount of alpha-fetoprotein tumor marker in a sample.


Alpha-Fetoprotein Positive

description: An indication that alpha-fetoprotein has been detected in a sample.


anilines

Any  aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives.


A phosphonic acid having a 4-[(2-aminophenyl)thio]butyl attached to the phosphorus; reported to have herbicidal properties.


CARBOL-FUCHSIN

An imine that is 4-methylidenecyclohexa-2,5-dien-1-imine in which both the hydrogens of the methylidene group are replaced by 4-amino-3-methylphenyl groups. The hydrochloride salt is the histological dye 'magenta II'.


name: thiocyanic acid [3-methoxy-4-[[3-methyl-1-(4-methylphenyl)-5-oxo-4-pyrazolylidene]methylamino]phenyl] ester


A member of the class of pyrimidines that is pyrimidine which is substituted at positions 2, 4, and 6 by 2,4-dichloroanilino, trifluoromethyl, and {2-[(1E)-1,3-dimethoxy-3-oxoprop-1-en-2-yl]benzyl}oxy groups, respectively. An acaricide used for the control of mites on citrus and cotton crops.


A member of the class of benzaldehydes that is salicylaldehyde in which the hydrogen para- to the hydroxy group is substituted by an amino group.


nitroaniline

A substituted aniline that carries one or more nitro groups.


fluoroaniline

A substituted aniline carrying an additional fluoro substituent on the benzene ring.


name: 5-amino-3-(4-methoxyphenyl)-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid ethyl ester


volasertib

A member of the class of pteridines that is (7R)-7-ethyl-5-methyl-8-(propan-2-yl)-7,8-dihydropteridin-6(5H)-one substituted by a [4-({trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}carbamoyl)-2-methoxyphenyl]amino group at position 2. It is as polo-like kinase 1 inhibitor (IC50 = 0.87 nM) with potential antineoplastic activity.


N-phenyl-D-glucopyranosylamine

An N-D-glucosylarylamine that is D-glucopyranose in which the hydroxy group at position 1 is replaced by an anilino group.


A member of the class of amino-nitrotoluenes that is 2,4-diaminotoluene bearing a nitro substituent at position 6.


Solvent yellow 56

An azobenzene that is N,N-diethylaniline substituted at position 4 by a phenylazo group.


(R)-mosapride

A 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide that has (R)-configuration.


An aromatic ketone that is 1-(2-aminophenyl)decane carrying two oxo substituents at positions 1 and 3.


telatinib

A member of the class of furopyridazines that is furo[2,3-d]pyridazine substituted by (4-chlorophenyl)amino and [2-(methylcarbamoyl)pyridin-4-yl]methoxy groups at positions 4 and 7, respectively. It is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRalpha.


(R)-aminoglutethimide

The (3R)-enantiomer of aminoglutethimide.


levesquamide

A polyketide-nonribosomal peptide with an isothiazolinone moiety found in Streptomyces sp. RKND-216. It has a strong selective activity against M. tuberculosis, with no cytotoxicity against mammalian cell lines.


A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3, 5, and 7 by cyano, {3-acetamido-4-[(2-aminoethyl)(methyl)amino]phenyl}nitrilo and cyclopropylnitrilo groups, respectively. It is a DYRK2 and CSNK2A2 kinase inhibitor.


3-(4-aminophenyl)pyruvic acid

A 2-oxo monocarboxylic acid that is 3-(4-aminophenyl)propanoic acid which is substituted by an oxo group at position 2.


A member of the class of quinazolines that is quinazoline which is substituted by a (3-methoxyphenyl)nitrilo group at position 4.


A pyrazolopyridazine that is pyrazolo[1,5-b]pyridazine which is substituted by a 2-anilinopyrimidin-4-yl group at position 3 and by an ethoxy group at position 6.


N-(4-aminobenzoyl)-L-glutamic acid

A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.


FUCHSIN, BASIC

An imine that is 4-methylidenecyclohexa-2,5-dien-1-imine in which the hydrogens of the methylidene group are replaced by 4-aminophenyl and 3-methyl-4-aminophenyl groups. The monohydrochloride salt is the histological dye 'rosanilin'.


A sulfonamide resulting from the formal condensation of the amino group of 2-aminobenzothiazole with the sulfo group of 4-[(2-hydroxy-3-methoxybenzyl)amino]benzenesulfonic acid. It is an inhibitor of 12-lipoxygenase, being developed by Veralox Therapeutics for the treatment of heparin-induced thrombocytopenia and thrombosis.


dimethylaniline

A methylaniline carrying at least two methyl groups.


KYNURAMINE

A member of the class of kynurenamines that is aniline substituted at position 2 by a 3-aminopropanoyl group.


A pyrrolopyrimidine that is 3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one substituted by [2-(2,5-difluoroanilino)-2-hydroxyethyl]sulfanediyl, ethyl, and phenyl groups at positions 2, 3, and 7, respectively. It inhibits androgen-induced ROS production.


florbetaben

A member of the class of stilbenoids in which the para-hydrogens of stilbene are replaced by methylamino and 2-{2-[2-((18)F)fluoroethoxy]ethoxy}ethoxy) groups. A positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease.


A substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine.


p-anisidine

A substituted aniline that is aniline in which the hydrogen para to the amino group has been replaced by a methoxy group. It is used as a reagent for the detection of oxidation products such as aldehydes and ketones in fats and oils.


name: 2-cyano-2-(1-phenyl-4-pyrimidinylidene)acetic acid ethyl ester


ZM 323881

A member of the class of quinazolines carrying 2-fluoro-4-methyl-5-hydroxyanilino and benzyloxy substituents at positions 4 and 7 respectively.


A member of the class of amino-nitrotoluenes that is 4-amino-6-nitrotoluene bearing an additional hydroxylamino group at position 2.


2-aminophenylglyoxylic acid

A 2-oxo monocarboxylic acid that is glyoxylic acid in which the aldehydic hydrogen is replaced by a 2-aminophenyl group.


A 6-oxo monocarboxylic acid that is 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid in with one of the ortho positions of the phenyl ring is substituted by an amino group.


basic brown 1

A bis(azo) compound that is 1,1'-(1,3-phenylene)bis(diazene) in which both azene hydrogens are replaced by 2,4-diaminophenyl groups. A metachromatic dye which stains acid mucins yellow. It is also a constituent of Papanicolaou's EA solutions, used for cervical, and other smears. Its dihydrochloride salt is also a biological dye known as Bismark brown Y.


A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione substituted by (2R)-2,3-dihydroxypropyl, (2-fluoro-4-iodophenyl)amino, fluoro, and methyl groups at positions 3, 5, 6, and 8, respectively. It is a non-ATP competitive allosteric inhibitor of MEK1/2.


The D-enantiomer of 4-aminophenylalanine.


monodechloroaminopyrrolnitrin

A member of the class of pyrroles carrying a 2-amino-3-chlorophenyl substituent at position 3.


A member of the class of enamides obtained by formal condensation of the carboxy group of 2-benzamido-3-phenylprop-2-enoic acid with the aromatic amino group of 2-[(4-aminophenyl)sulfanyl]propanoic acid, the carboxy group of which has also undergone formal condensation with the amino group of 5-chloro-2,4-dimethoxyaniline.


A nitroaniline consisting of an aniline core having two nitro substituents located at the 2- and 4-positions.


A phenol substituted by amino and methoxy groups at positions 2 and 5, respectively.


varlitinib

A member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours.


MP-PYT

A member of the class of barbiturates that is barbituric acid in which one of the nitrogens (position 1) is substituted by a p-tolyl group while the carbon at position 5 is substituted by a (2E)-3-[p-(dimethylamino)phenyl]allylidene group. It has significant osteogenic activity.


A member of the class of quinazolines that is quinazoline which is substituted at positions 2 and 4 by pyridin-4-yl and (3-fluorophenyl)nitrilo groups, respectively.


A member of the class of amino-nitrotoluenes that is 2-amino-6-nitrotoluene bearing an additional acetamido group at position 4.


3,5-dihydroxyanthranilic acid

A dihydroxybenzoic acid that is 3,5-dihydroxybenzoic acid substituted by an amino group at position 2.


sulfathiourea

A substituted aniline that is thiourea in which one of the hydrogens has been replaced by a (p-aminophenyl)sulfonyl group.


ASULAM

A carbamate ester that is methyl carbamate substituted by a (4-aminophenyl)sulfonyl group at the nitrogen atom. A dihydropteroate synthase inhibitor, it is used (normally as the corresponding sodium salt, asulam-sodium) as a herbicide, mainly for killing bracken.


A pyrazolopyridazine that is pyrazolo[1,5-b]pyridazine which is substituted by a 2-(3-methoxyanilino)pyrimidin-4-yl group at position 3 and by an ethoxy group at position 6. It is a CLK4 kinase inhibitor.


A member of the class of benzaldehydes that is benzaldehyde carrying a dimethylamino substituent at position 4. Used as an indicator for detection of indoles and hydrazine.


Product of the enzymatic  deamination of kynuramine.


sulfametrole

A sulfonamide obtained by formal condensation of the sulfo group of 4-aminobenzenesulfonic acid with the amino group of 4-methoxy-1,2,5-thiadiazol-3-amine.


A piperidinemonocarboxylic acid that is 4-phenylisonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl)ethyl group.


A member of the class of dimethylanilines that is N,N-dimethylaniline having a hydroxylamino substituent at the 4-position.


ACLONIFEN

A primary amino compound that is aniline in which the phenyl group has been substituted at positions 2, 3, and 6 by chlorine, phenoxy, and nitro groups, respectively. A protoporphyrinogen oxidase (PPO) inhibitor, it is used as a herbicide against a broad range of weeds in a wide range of crops.


terreazepine

A member of the class of benzazepines that is 2,3,4,5-tetrahydro-1H-1-benzazepine substituted by oxo groups at positions 2 and 5 and a o-aminobenzamido group at position 4. It is a secondary metabolite found in Aspergillus terreus.


hydroxykynurenamine

Any kynurenamine carrying a hydroxy substituent.


A member of the class of quinazolines that is quinazoline-2,4-diamine in which one of the hydrogens attached to the amino group at position 2 is replaced by a 3-chloro-4-methylphenyl group. It has been found to stimulate the immune defences of the nematode Caenorhabditis elegans, so affording protection from bacterial infection.


florbetapir

An aromatic ether consisting of a pyridine ring substituted at position 2 by a 2-{2-[2-((18)F)fluoroethoxy]ethoxy}ethoxy group and at position 5 and a 2-(4-methylaminophenyl)vinyl group. A positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease.


squarylium dye III

A squaraine dye having two 4-dimethylaminophenyl substituents attached to the cyclobutane ring.


new fuchsin free base

An imine that is 2-methyl-4-methylidenecyclohexa-2,5-dien-1-imine in which both the hydrogens of the methylidene group are replaced by 4-amino-3-methylphenyl groups. The hydrochloride salt is the histological dye 'new fuchsin'.


A ribose monophosphate that is 4-(beta-D-ribofuranosyl)aminobenzene carrying a single monophospate substituent at position 5'.


auramine O free base

A member of the class of imines that is benzophenone imine carrying two dimethylamino substituents at positions 4 and 4'. The hydrochloride salt is the biological stain 'auramine O'


bentioflumin

An aryl sulfide that is benzene substituted by {[2-(methoxycarbonyl)phenyl]methyl}amino, fluoro, chloro, and (2,2,2-trifluoroethyl)sulfanediyl groups at positions 1, 2, 4 and 5, respectively. It is an acaricide discovered by Shandong Kangqiao Bio-technology Co. Ltd that is highly effective against citrus rust mites, red spider mites, and two-spotted spider mites and has excellent leaf penetration properties.


BENFLURALIN

A tertiany amino compound that is 2,6-dinitro-4-(trifluoromethyl)aniline in which the hydrogens attached to the aniline nitrogen have been replaced by one ethyl and one butyl group. It is used as a pre-emergence herbicide used for the control of grass and other weeds in a range of food and non-food crops.


para-isopropylaniline

A substituted aniline carrying an isopropyl group at position 4. It is a metabolite of isoproturon.


aminotoluene

Any member of the class of  toluenes carrying one or more amino groups.


2-aminophenyl hydrogen sulfate

An aryl sulfate that is 2-aminophenol in which the phenolic hydrogen has been replaced by a sulfo group.


name: 2-[(5-chloro-2-methoxyphenyl)hydrazinylidene]-2-cyanoacetic acid ethyl ester


A dioxo monocarboxylic acid that is benzene in which the hydrogens at position 1, 2 and 3 are replaced by 3-carboxy-3-oxopropanoyl, amino and hydroxy groups, respectively. It is a by-product of tryptophan metabolism.


A member of the class of xanthenes that is used as a Zn(2+)-selective fluorescent indicator.


An ethyl ester resulting from the formal condensation of the carboxy group of 3-(benzylamino)-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM).


A member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors.


An aromatic ketone that is acetophenone in which one of the ortho hydrogens of the phenyl group has been replaced by an amino group.


A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3, 5, and 7 by cyano, (4-methyl-3-propanamidophenyl)nitrilo and cyclopropylnitrilo groups, respectively. It is a potent and selective chemical probe for the pleiotropic kinase CK2.


GGTI-2133 free base

An N-acyl-L-amino acid obtained by condensation of the carboxy group of 4-{[(imidazol-4-yl)methyl]amino}-2-(naphthalen-1-yl)benzoic acid with the amino group of L-leucine. An inhibitor of geranylgeranyltransferase type I.


A pyrazolopyridazine that is pyrazolo[1,5-b]pyridazine which is substituted by a 2-[3-methoxy-5-(trifluoromethyl)anilino]pyrimidin-4-yl group at position 3 and by a methoxy group at position 6. It is a human GSK-3beta, CDK2, CDK4, CLK1, CLK2, and CLK4 kinase inhibitor.


amino-nitrotoluene

A nitrotoluene carrying at least one amino group.


A member of the class of benzamides that is entinostat in which the hydrogen that is para to the nitrogen of the benzamide moiety has been replaced by a fluorine.


Major species at pH 7.3.


A hydroxybenzaldehyde that is 4-hydroxybenzaldehyde bearing an additional amino substituent at position 3.


A member of the class of amino-nitrotoluenes that is 2,6-diaminotoluene bearing a nitro substituent at position 4.


A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF(V600E), BRAF(WT) and CRAF(WT) (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties.


solabegron

A carboxybiphenyl that is [biphenyl]-3-carboxylic acid carrying a (2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)nitrilo group at the 3' position. A selective beta3-adrenergic receptor agonist currently in clinical development for the treatment of overactive bladder and irritable bowel syndrome.


A substituted aniline that is 3-nitroanisole in which the hydrogen para to the methoxy group is replaced by an amino group.


A hydroxykynurenine  that is kynurenine substituted by a hydroxy group at position 3.


Methyl violet 2B free base

An imine that is 4-methylidenecyclohexa-2,5-dien-1-imine in which both the hydrogens of the methylidene group are replaced by 4-(dimethylamino)phenyl groups. The hydrochloride salt is the histological dye 'Methyl violet 2B'.


A phenylalanine derivative that is phenylalanine carrying an amino group at position 4 on the benzene ring.


amfenac

An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.


hydroxykynurenine

A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.


D-kynurenine

A kynurenine that has D configuration.


A 6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid in which the two double bonds adopt E,E-configuration.


An ethyl ester resulting from the formal condensation of the carboxy group of 4-[(adamantan-1-yl)amino]-3-{(Z)-[(pyrimidin-5-yl)methylidene]amino}benzoic acid with tert-butanol. It is an inhibitor of ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 muM.


(S)-aminoglutethimide

The (3R)-enantiomer of aminoglutethimide.


tacedinaline

A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.


2-aminophenylacetic acid

A member of the class of phenylacetic acids that is phenylacetic acid which carries an amino group at position 2 of the phenyl ring. A fungal metabolite produced by Colletotrichum gloeosporioides.


A substituted aniline in which the aniline ring carries 4-hydroxy and 2,6-dimethyl substituents; a urinary metabolite of lidocaine.


name: 5-(2-anilino-4H-1,3,4-thiadiazin-5-ylidene)-2,4-dimethyl-3-pyrrolecarboxylic acid ethyl ester


A member of the class of dimethylanilines that is N,N-dimethylaniline having a nitroso group at the 4-position.


N-acetylkynurenine

A member of the class of acetamides obtained by acetylation of one of the amino groups of kynurenine.


A member of the class of biphenyls that is benzidine in which one of the hydrogens ortho to each of the amino groups has been replaced by an amino group.


methylaniline

A substituted aniline carrying one or more methyl groups at unspecified positions.


A member of the class of purines that is carrying 9-cyclopentyl-9H-purine-2,8-diamine in which the amino groups at positions 2 and 8 are carrying 4-methoxyphenyl and 2-fluorophenyl substituents respectively.


2-aminobenzoylacetic acid

A 3-oxo monocarboxylic acid that is benzoylacetic acid substituted at position 2 on the benzene ring by an amino group.


sulfaperin

A substituted aniline that is sulfanilamide in which on of the hydrogens of the sulfonamide group has been replaced by a 5-methylpyrimidin-2-yl group.


A hydroxytoluene that is phenol substituted by amino and methyl groups at positions 2 and 4, respectively. It is a metabolite of disperse yellow 3.


N-isopropylaniline

A substituted aniline in which one of the hydrogens of the amino group has been replaced by an isopropyl group.


An aminophenol that is one of three amino derivatives of phenol which has the single amino substituent located meta to the phenolic -OH group.


A hydroxykynurenamine where the hydroxy group is located at the 5-position.


BUTYL 2-AMINOBENZOATE

A benzoate ester obtained by formal condensation of the carboxy group of anthranilic acid with the hydroxy group of butanol. Found in several fruit species, it is used as a flavouring and fragrance agent and also exhibits insect repellent properties.


(S)-mosapride

A 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide that has (S)-configuration.


An anilide that is N-phenylacetamide substituted by an amino group at position 3 and a chloro group at position 4 respectively.


elacestrant

A member of the class of tetralins that is 1,2,3,4-tetrahydronaphthalene which is substituted by hydroxy group at position 2 and by a 2-(ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl group at position 6R. It is a is an estrogen receptor degrader indicated for the treatment of postmenopausal women or adult men, with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy.


A benzamide resulting from the formal condensation of the carboxy group of 5-amino-2-methylbenzoic acid with the amino group of (1R)-1-(naphthalen-1-yl)ethan-1-amine. It is a potent noncovalent inhibitor (IC50 = 600 nM) of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro).


KYNURENINE

A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.


A hydroxykynurenamine that is kynurenamine carrying a hydroxy group at position 3. It is a metabolite of tryptophan that exhibits antiinflammatory and immunomodulatory properties.


An acetamide that is 1,4-phenylenediamine in which the the amino group at position 4 is replaced by an acetylamino group.


2-METHYLAMINOBENZOIC ACID METHYL ESTER

A methyl ester resulting from the formal condensation of the carboxy group of N-methylanthranilic acid with methanol.


A member of the class of aminotoluenes that is 2,4-diaminotoluene bearing an additional hydroxylamino substituent at position 6.


alminoprofen

A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders.


N,N-dimethylaniline N-oxide

A member of the class of dimethylanilines that is N,N-dimethylaniline in which the tertiary amino group has been oxidised to give the corresponding N-oxide.


name: N-(4-methoxyphenyl)carbamic acid [(1-tert-butyl-3,5-dimethyl-4-pyrazolyl)methylideneamino] ester


AMINOPOTENTIDINE

A benzamide obtained by formal condensation of the carboxy group of 4-aminobenzoic acid with the primary amino group of 1-(2-aminoethyl)-2-cyano-3-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}guanidine.


The L-enantiomer of 4-aminophenylalanine.


A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group.  SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.


aminophenol

A substituted aniline carrying a hydroxy substituent. A 'closed class'.


sulfanilamide

A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position.


A hydroxykynurenamine that is 5-hydroxykynurenamine with the hydrogen on the aryl amine  replaced by a formyl group.


A secondary carboxamide resulting from the formal condensation of the amino group of (1R,2R)-2-amino-1-(4-aminophenyl)propane-1,3-diol with the carboxy group of dichloroacetic acid. It is an intermediate used in the biosynthesis pathway of the antibiotic, chloramphenicol.


aminopyrrolnitrin

A member of the class of pyrroles carrying chloro and 2-amino-3-chlorophenyl substituents at positions 3 and 4 respectively.


A member of the class of quinazolines that is quinazoline which is substituted at positions 2 and 4 by pyridin-4-yl and (4-methylphenyl)nitrilo groups, respectively.


An aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor.


DMP-PYT

A member of the class of barbiturates that is barbituric acid in which one of the nitrogens (position 1) is substituted by a 3,5-dimethylphenyl group while the carbon at position 5 is substituted by a (2E)-(3-[p-(dimethylamino)phenyl]allylidene group. It has significant osteogenic activity.


A  hydroxykynurenine  that is kynurenine bearing a hydroxy group at the position 5.


Growth Plate Open

description: An indication that the epiphyseal plate is made of hyaline cartilage and is not yet fused by bone.


Activating ROS1 Gene Mutation Negative

description: A genetic finding indicating that mutations in the ROS1 gene which encode constitutively active forms of the proto-oncogene tyrosine-protein kinase ROS protein are not present in a sample.


SAPROPTERIN DIHYDROCHLORIDE

The dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase.


fluorenes

An ortho-fused polycyclic arene in which the skeleton is composed of two benzene rings ortho-fused to cyclopentane.


hydroxyfluorenes

Any member of the class of  fluorenes containing a mono- or poly-substituted  fluorene ring in which at least one of the substituents is a hydroxy group.


A member of the class of  hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon).


A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is replaced by a 9H-fluoren-4-yl group.


A 2-acetamidofluorene compound in which the parent 2-acetamidofluorene is substituted on nitrogen by an acetoxy group.


A fluorene derivative obtained by formal dihydroxylation across the 3,4-position of fluorene (the 3S,4R-diastereomer).


N-2-fluorenylphthalamic acid

A member of the class of fluorenes that is 9H-fluorene substituted by a (2-carboxybenzoyl)amino group at position 2.


A fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase.


caulophine

A member of the class of fluoren-9-ones that is 9H-fluoren-9-one substituted by 2-(dimethylamino)ethyl group at position 3, hydroxy groups at positions 4 and 5 and two methoxy groups at positions 1 and 6 respectively. It is isolated from the radix of Caulophyllum robustum and exhibits anti-myocardial ischemia activity.


name: 9-oxo-3-fluorenecarboxylic acid (phenylmethyl) ester


An ortho-fused polycyclic arene, or derivative thereof, that consists of 9H-fluorene bearing an acetamido substituent at position 2.


A member of the class of  fluorenes carrying an oxo substituent at position 9.


A member of the class of  hydroxyfluorenes that is 9H-fluorene substituted by hydroxy groups at positions 1 and 2.


name: 2-[[(4-ethoxyphenyl)-oxomethyl]amino]acetic acid [2-(9H-fluoren-3-yl)-2-oxoethyl] ester


The simplest member of the class  fluoren-9-ones that is 9H-fluorene bearing an oxo substituent at position 9.


Primary Insomnia

description: A sleep disorder characterized by difficulty initiating or maintaining sleep; this difficulty does not occur in the context of another sleep disorder and is not etiologically linked to a mental disorder, substance use, or a general medical condition.


selenomethionine

The L-enantiomer of selenomethionine.


sapphyrin

A cyclic pentapyrrole where the five pyrrole units are joined at their 2- and 5-positions via four methine linkages and one direct 2-5'-linkage.


Rheumatoid Nodule, Right Ankle and Foot

description: Evidence of rheumatoid nodule in the right ankle and foot.


valienone

A member of the class of cyclohexenones that is cyclohex-2-en-1-one substituted by hydroxy groups at positions 4, 5 and 6, and by a hydroxymethyl group at position 3 (the 4R,5S,6R-diastereomer).


tetrol

A polyol that contains 4 hydroxy groups.


A hydroxycalciol that is a synthetic fluorinated and deuterated analogue of vitamin D3 which exhibits vitamin D receptor superagonist and anti-cancer activity.


21-deoxyconcanamycin A

A macrolide antibiotic that is a semisynthetic analogue of concanamycin A, possessing an 18-membered lactone ring and a 6-membered oxane ring in which the hydroxy group at position 23 is glycosylated by a 4-O-carbamoyl-2,6-dideoxy-beta-D-arabino-hexopyranosyl residue.


stemphyloxin I

An octahydronaphthalene that is 2,4,5,7-tetramethyloctahydronaphthalen-1(2H)-one which is substituted by hydroxy groups at positions 2 and 7, a (2R)-1-hydroxybutan-2-yl group at position 3, and a (2Z)-3-hydroxyprop-2-enoyl group at position 4 (the 2S,3R,4R,4aS,5R,7R,8aS stereoisomer). Isolated from the endophytic fungus Stemphylium botryosum, it is the causal agent of leaf spot and foliage blight disease in tomatoes. Its phytotoxcity is at least 200 times greater than that of stemphyloxin II. It shows high affinity for Fe(3+) (but not Fe(2+)) ions.


A hydroxyindole that is 1H-indole-5,6-diol substituted by a 5,6-dihydroxy-1H-indol-3-yl group at position 3.


oligomycin C

An oligomycin with formula C45H74O10 that is oligomycin A in which the hydroxy group that is alpha- to a macrolide keto group has been replaced by a hydrogen. It is an inhibitor of the mitochondrial F1F0 ATP synthase.


pavettamine

An aminoalcohol that is N(1)-(5-aminopentyl)pentane-1,5-diamine substituted by hydroxy groups at positions 2, 2', 4 and 4' (the 2R,4S,2'R,4'S-stereoisomer). It is a toxin produced by several plant species and the casual agent of gousiekte (''quick'' disease).


An isoquinoline substituted by 3,4-dihydroxybenzoyl, carboxy, hydroxy, and hydroxy groups at positions 1, 3, 6, and 7, respectively. It is a potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP).


A tetrol that is 2-aminoicosane with the four hydroxy substituents located at position 1, 3, 4 and 5.


dehydroascorbic acid dimer

An organic heteropentacyclic compound obtained by cyclodimerisation of ascorbic acid.


NOGALAMYCIN

An anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties.


1alpha,23(S),25-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) bearing additional hydroxy substituents at positions 1, 23 and 25 (with 1alpha,23S-configuration). An intermediate in the degradation pathway of 1alpha,25-(OH)2D3.


(20S,23,24)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration), 23 and 24.


The  (-)-(7R,8S)-stereoisomer of  guaiacylglycerol. It has been isolated from the stems of Sinocalamus affinis.


cryptocaryol B

A member of the class of 2-pyranones that is 5,6-dihydro-2H-pyran-2-one substituted by a 10-(acetyloxy)-2,4,6,8-tetrahydroxypentacosyl group at position 6.It has been isolated from Cryptocarya species.


A vitamin D that is 19-norcalcitriol carrying an additional 3-hydroxypropyl substituent at position 2. A synthetic analogue of vitamin D, it exhibits anticancer properties.


The (-)-(7S,8S)-stereoisomer of guaiacylglycerol. It has been isolated from the stems of Sinocalamus affinis.


nordihydroguiaretic acid

A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor.


A tetrahydroxytetrahydrofuran in which the hydroxy groups are located at positions 2, 3, 4, and 4 and which is substituted by a methyl group at position 2 (the 2R,4S diastereoisomer).


perquinoline C

A perquinoline that is 8-hydroxy 20-N-butanoic acid.


A member of the class of cyclohexenones that is 5-(hydroxymethyl)cyclohex-2-en-1-one carrying three additional hydroxy substituents at positions 2, 3 and 5.


A  lignan that consists of a tetrahudrofuran substituted by a 4-hydroxy-3-methoxyphenyl group at position 5, a hydroxymethyl group at position 4 and a hydroxy(4-hydroxy-3-methoxyphenyl)methyl group at position 3. It has been isolated from Taxus yunnanensis.


ent-pavettamine

An aminoalcohol that is N(1)-(5-aminopentyl)pentane-1,5-diamine substituted by hydroxy groups at positions 2, 2', 4 and 4' (the 2R,4S,2'R,4'S-stereoisomer).


DEMETHYLBELLIDIFOLIN

A member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris.


PURPUROGALLIN

A cyclic ketone that is 5H-benzocycloheptene bearing an oxo group at position 5 and hydroxy groups at positions 2, 3, 4 and 6.


dihydrostemphyloxin I

An octahydronaphthalene that is stemphyloxin I in which the C=C bond of the enol moiety has been reduced to a C-C bond.


sceliphrolactam

A polyene macrocyclic lactam with formula C28H35NO6. It was isolated from an actinomycete, Streptomyces sp. and displays antifungal activity against amphotericin B-resistant Candida albicans.


gigantetronenin

A member of the class of oxolanes that is tetrahydrofuran substituted by a  6-hydroxy-7-(5-methyl-2-oxo-2,5-dihydrofuran-3-yl)heptyl group at position 2 and a (8Z)-1,4,5-trihydroxyhenicos-8-en-1-yl group at position 5. Isolated from Goniothalamus giganteus, it exhibits cytotoxic activity.


eucommiol

An alicyclic compound that is cyclopent-3-en-1-ol carrying additional hydroxymethyl substituents at positions 3 and 4 as well as a 2-hydroxyethyl substituent at position 2 (the 1R,2R-diastereomer).


A hydroxyquinoline that is quinoline substituted by hydroxy groups at positions 3, 4, 5, and 8.


benzenetetrol

Any member of the class of benzenes that is benzene substituted by four hydroxy groups at unspecified positions.


GUAIACYL GLYCEROL

A compound made up of a guaiacyl core with an alpha-glyceryl substituent para to the aromatic hydroxy group.


pentaerythritol

A tetrol that is neopentane in which one of the methyl hydrogens of all four methyl groups are replaced by hydroxy groups. It is a chemical intermediate used in the production of explosives, plastics, paints, appliances, and cosmetics.


An oxime ether that is 3,6-bis(methoxyimino)hexane carrying four hydroxy substituents at positions 1, 2, 4 and 5.


(20S,23,25)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration), 23 and 25.


A hydroxycalciol that is a synthetic fluorinated and deuterated analogue of vitamin D3 which exhibits vitamin D receptor superagonist and anti-cancer activity.


A hydroxycalciol that is calcitriol with a 4-hydroxybutoxy group at position 2.


A phosphatidylcholine 24:0 in which the acyl groups specified at positions 1 and 2 are tetradecanoyl and decanoyl respectively.


Cor triloculare

description: A congenital anatomic anomaly in which the heart has only three chambers.


Grade 5 Urostomy Leak, CTCAE

description: Death


name: Splenic Manifestation of Chronic Lymphocytic Leukemia

description: Infiltration of the spleen by chronic lymphocytic leukemia. It primarily involves the white pulp.


Adenosarcoma pN1 TNM Finding v7

description: Regional lymph node metastasis. (from AJCC 7th Ed.)


CYSTODYTIN G

An alkaloid that is an enamide obtained by the formal condensation of tiglic acid with 6-(2-amino-1-methoxyethyl)-4H-pyrido[2,3,4-kl]acridin-4-one. It is isolated from the Okinawan marine tunicate Cystodytes dellechiajei and exhibits cytotoxicity against human epidermoid carcinoma KB cells


A 6-lactoyl-5,6,7,8-tetrahydropterin in which the stereocentre at position 6 has R-configuration.


name: Trace Residue Within or On Pharyngeal Structures Following Swallowing

description: A finding of trace residue within or on pharyngeal structures following swallowing.


Pharyngeal Residue

description: Substance remaining in the pharynx after swallowing.


name: Collection of Residue Within or On Pharyngeal Structures Following Swallowing

description: A finding of collection of residue within or on pharyngeal structures following swallowing.


Diffuse Residue Following Swallowing

description: A finding of diffuse residue following swallowing.


name: Complete Pharyngeal Clearance Following Swallowing

description: A finding of complete pharyngeal clearance following swallowing.


name: Minimal to No Pharyngeal Clearance Following Swallowing

description: A finding of minimal to no pharyngeal clearance following swallowing.


name: Majority of Contrast Within or On Pharyngeal Structures Following Swallowing

description: A finding of the majority of contrast within or on pharyngeal structures following swallowing.


Kaposi's sarcoma of oral cavity

description: Kaposi sarcoma arising from the oral cavity.


Parotid Gland Lipoma

description: A lipoma that arises from the parotid gland.


A lysophosphatidylethanolamine zwitterion in which the remaining acyl group (position not specified) contains 20 carbons and 0 double bonds.


An amino trisaccharide consisting of 2-acetamido-2-deoxy-alpha-D-galactopyranose, beta-D-galactopyranose and alpha-D-glucopyranose residues joined in sequence by (1->3) and (1->4) glycosidic bonds.


poacic acid

A hydroxycinnamic acid that is (2E)-3-phenylprop-2-enoic acid in which the hydrogens at positions 3, 4 and 5 are replaced by 2-(4-hydroxy-3-methoxyphenyl)ethenyl, hydroxy and methoxy groups, respectively. It is a natural product found in maize bran which exhibits antifungal activities against several fungal and oomycete pathogens including Sclerotinia sclerotiorum, Alternaria solani, and Phytophthora sojae. It inhibits beta-1,3-glucan synthesis in cells walls resulting in rapid cell lysis.


Grade 1 Irregular Menstruation, CTCAE

description: Intermittent/irregular menses for no more than 3 consecutive menstrual cycles


name: Ocular Adnexal Lymphoma pN3 TNM Finding v8

description: Ocular adnexal lymphoma with diffuse or disseminated involvement of peripheral and central lymph node regions. (from AJCC 8th Ed.)


diazine

The parent structure of the diazines.


4-hydroxy-3-methylbenzoic acid

A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methyl group at position 3.


An  oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.


Grade 3 Headache, CTCAE

description: Severe pain; limiting self care ADL


Headache, CTCAE

description: A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.


Grade 1 Headache, CTCAE

description: Mild pain


Grade 2 Headache, CTCAE

description: Moderate pain; limiting instrumental ADL


Gastric Anastomotic Leakage

description: Leakage due to breakdown of a gastric anastomosis.


name: Solitary Plasmacytoma not Having Achieved Remission

description: Evidence of solitary plasmacytoma not having achieved remission.


name: benzoic acid [3,4-dibenzoyloxy-5-(2,4-dioxo-5-propan-2-yl-1-pyrimidinyl)-2-oxolanyl]methyl ester


APRATOXIN D

An aprotoxin having the common aprotoxin cyclodepsipeptide skeleton where the isoleucyl residue carries an N-methyl substituent and the side-chain adjacent to the lactone is (2R)-4,4-dimethylpentan-2-yl. It is isolateed from Lyngbya majuscula and Lyngbya sordida and exhibits anticancer properties.


A 2,3-diacyl-1-alpha-D-galactosyl-sn-glycerol in which the groups at the 2- and 3-positions are oleoyl and palmitoyl respectively.


enediyne

Any organic entity containing a conjugated system of two carbon-carbon triple bonds separated by a carbon-carbon double bond (i.e. a 3-ene-1,5-diyne system).


Penile Cancer cNX TNM Finding v7

description: Penile cancer in which the regional lymph nodes cannot be assessed.  (from AJCC 7th Ed.)


ethyl phenylcyanoacetate

An alpha-substituted cyanoacetate ester that consists of ethyl cyanoacetate bearing an alpha-phenyl substituent.


A 1-alkyl-2-acyl-sn-glycero-3-phosphate in which the alkyl and acyl groups are specified as palmityl (hexadecyl) and oleoyl respectively.


A glycerophosphoethanolamine that is sn-glycero-3-phosphoethanolamine in which positions 1 and 2 are substituted by unspecified acyl and alkyl groups, and in which the positions of the acyl and alkyl groups are also unspecified.


phosphatidylethanolamine O-37:1

An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 37 carbons and 1 double bond.


An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which unspecified alkyl and acyl groups are located at positions 1 and 2 respectively.


A 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine in which the alkyl and the acyl groups at positions 1 and 2 are specified as eicosyl and linolenyl respectively.


phosphatidylethanolamine O-39:5

An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 39 carbons and 5 double bonds.


An alkyl,acyl-sn-glycero-3-phosphoethanolamine in which unspecified acyl and alkyl groups are located at positions 1 and 2 respectively.


A 2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine in which the alkyl and the acyl groups at positions 1 and 2 are specified as hexadecyl and acetyl respectively.


azulenes

Any carbobicyclic compound whose skeleton consists of a cyclopentane ring ortho-fused to a cycloheptane ring.


A member of the class of azulenes that is azulene substituted by methyl groups at positions 4, 6 and 8 respectively.


azulene

A mancude carbobicyclic parent consisting of a cycloheptatriene and cyclopentadiene rings.


beta-D-quinovofuranose

A D-quinovose (6-deoxy-D-glucose) that is D-quinovofuranose in which the anomeric centre has beta configuration.


phytanoyl-CoA

The S-phytanoyl derivative of coenzyme A.


Ischemic Myocardium

description: Myocardial tissue which exhibits characteristics of inadequate blood flow.


Ischemic Myocardium Percentage

description: Percent of the myocardial tissue estimated to exhibit characteristics of inadequate blood flow (ischemia). This is usually determined using a functional study (e.g. MRI, SPECT or PET).


name: Nasal Cavity and Paranasal Sinuses Cancer cNX TNM Finding v8

description: Nasal cavity and paranasal sinuses cancer in which the regional lymph nodes cannot be assessed. (from AJCC 8th Ed.)


manganese(II) sulfate hexahydrate

A hydrate that is the hexahydrate form of manganese(II) sulfate.


name: Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Ann Arbor Stage I Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


name: Ann Arbor Stage I Subdiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


name: Other Specified Rheumatoid Arthritis, Right Shoulder

description: Evidence of other specified rheumatoid arthritis in the right shoulder not specified elsewhere.


A triacyl-sn-glycerol in which the 1-acyl group is octadecanoyl while the 2- and 3-acyl groups are oleoyl.


name: Distal Bile Duct Cancer pN1 TNM Finding v8

description: Distal bile duct cancer with metastasis in one to three regional lymph nodes. (from AJCC 8th Ed.)


Diaper candidiasis

description: An inflammatory skin condition in the diaper area superimposed with Candida infection, characterized by a bright red rash with a sharply demarcated edge and satellite lesions. Skin folds are often involved.


The (6aS,11aS)-enantiomer of pterocarpan.


GLYCEOLLIN III

A benzofuropyranochromene that is 1,2-dihydro-6H-[1]benzofuro[3,2-c]furo[3,2-g]chromene substituted at positions 6a and 9 by hydroxy groups and at position 2 by a prop-1-en-2-yl group.


GLYCEOLLIN II

A benzofuropyranochromene that is 3H,7H-[1]benzofuro[3,2-c]pyrano[3,2-g]chromene substituted at positions 7a and 10 by hydroxy groups and at position 3 by a gem-dimethyl group.


Grade 4 Arachnoiditis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Soft Tissue Sarcoma pNX TNM Finding v7

description: Soft tissue sarcoma in which regional lymph nodes cannot be assessed.  (from AJCC 7th Ed.)


A trisaccharide derivative consisting of an alpha-D-glucosyl residue glycosidically linked to a 5-aminopentyl group and which carries at O-4 an alpha-L-rhamnosyl-(1->3)-beta-D-glucosyl disaccharide unit.


name: Stage IB Adult Soft Tissue Sarcoma AJCC v7


name: 4-(2-phenylethylsulfamoyl)-1H-pyrrole-2-carboxylic acid methyl ester


name: Grade 3 Skin Breakdown or Decubitus Ulcer, CTCAE


Grade 3 Anal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 1 Pyramidal Tract Dysfunction, CTCAE


1-hexyl-3-methylimidazolium chloride

An organic chloride salt in which the cationic component is 1-hexyl-3-methylimidazolium.


name: Uterine Corpus Cancer pTis TNM Finding v6

description: Uterine corpus cancer in situ. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer Pathologic Primary Tumor TNM Finding v6

description: A pathologic finding about one or more characteristics of uterine corpus cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


name: Uterine Corpus Cancer pT2b TNM Finding v6

description: Uterine corpus cancer with invasion of the cervical stroma. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT2 TNM Finding v6

description: Uterine corpus cancer with invasion of the cervix without extension beyond the uterus. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT1b TNM Finding v6

description: Uterine corpus cancer with tumor invasion of less than one-half of the myometrium. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT3b TNM Finding v6

description: Uterine corpus cancer with tumor involvement of the vagina either from direct extension or metastasis. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT1a TNM Finding v6

description: Uterine corpus cancer with tumor limited to the endometrium. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT1c TNM Finding v6

description: Uterine corpus cancer with tumor invasion of one-half or more of the myometrium. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT3 TNM Finding v6

description: Uterine corpus cancer with local or regional involvement as defined in pT3a or pT3b. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT4 TNM Finding v6

description: Uterine corpus cancer with tumor invasion of the bladder mucosa or bowel mucosa. Bullous edema is not sufficient to classify a tumor as T4. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT0 TNM Finding v6

description: Uterine corpus cancer in which there is no evidence of a primary tumor. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT1 TNM Finding v6

description: Uterine corpus cancer with tumor confined to the corpus uteri. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT2a TNM Finding v6

description: Uterine corpus cancer limited to the glandular epithelium of the endocervix. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pTX TNM Finding v6

description: Uterine corpus cancer in which primary tumor cannot be assessed. (from AJCC 6th Ed.)


name: Uterine Corpus Cancer pT3a TNM Finding v6

description: Uterine corpus cancer with tumor involvement of the serosa or adnexa (either from direct extension or from metastasis), or with the presence of cancer cells in either ascites or peritoneal washings. (from AJCC 6th Ed.)


name: Medullary Thyroid Carcinoma cM0 TNM Finding v8

description: No distant metastasis. (from AJCC 8th Ed.)


name: Medullary Thyroid Carcinoma Clinical TNM Finding v8

description: A clinical finding about one or more characteristics of medullary thyroid carcinoma, following the rules of the TNM AJCC v8 classification system.


name: Medullary Thyroid Carcinoma cM1 TNM Finding v8

description: Distant metastasis. (from AJCC 8th Ed.)


name: Medullary Thyroid Carcinoma cN0b TNM Finding v8

description: No radiologic or clinical evidence of locoregional lymph node metastasis. (from AJCC 8th Ed.)


name: Medullary Thyroid Carcinoma Clinical Distant Metastasis TNM Finding v8

description: A clinical finding about one or more characteristics of medullary thyroid carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Medullary Thyroid Carcinoma cN1b TNM Finding v8

description: Metastasis to unilateral, bilateral, or contralateral lateral neck lymph node levels I, II, III, IV, or V or retropharyngeal lymph nodes. (from AJCC 8th Ed.)


name: Medullary Thyroid Carcinoma cN1 TNM Finding v8

description: Metastasis to regional nodes. (from AJCC 8th Ed.)


name: Medullary Thyroid Carcinoma cNX TNM Finding v8

description: Regional lymph nodes cannot be assessed. (from AJCC 8th Ed.)


name: Medullary Thyroid Carcinoma cN1a TNM Finding v8

description: Metastasis to level VI or VII (pretracheal, paratracheal, or prelaryngeal/Delphian, or upper mediastinal) lymph nodes. This can be unilateral or bilateral disease. (from AJCC 8th Ed.)


name: Medullary Thyroid Carcinoma Clinical Regional Lymph Nodes TNM Finding v8

description: A clinical finding about one or more characteristics of medullary thyroid carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.


name: Medullary Thyroid Carcinoma cN0 TNM Finding v8

description: No evidence of locoregional lymph node metastasis. (from AJCC 8th Ed.)


Congenital anomaly of tricuspid valve

description: A defect of the tricuspid valve present at birth.


(KDO)2-(palmitoleoyl)-lipid IVA

A lipid A comprising lipid IVA glycosylated with two 3-deoxy-D-manno-octulosonic acid (KDO) residues and carrying an additional palmitoleoyl group.


Retinoblastoma pT2b TNM Finding v7

description: Retinoblastoma with tumor superficially invading optic nerve head but not extending past lamina cribrosa and exhibiting focal choroidal invasion. (from AJCC 7th Ed.)