A lipid A oxoanion obtained via deprotonation of the carboxy and phosphate OH groups of galactosyl-(glucosyl)2-(heptosyl)3-(KDO)2-lipid A-bisphosphate.


phosphatidylserine O-42:2(1-)

An alkyl,acyl-sn-glycero-3-phospho-L-serine(1-) in which the alkyl or acyl groups at positions 1 and 2 contain a total of 42 carbons and 2 double bonds.


phosphatidylserine 30:2(1-)

A 3-sn-phosphatidyl-L-serine(1-) in which the acyl groups at C-1 and C-2 contain 30 carbons in total and 2 double bonds.


A steroid sulfate oxoanion obtained by deprotonation of the sulfo groups of (24S)-hydroxycholesterol 3,24-disulfate.


A 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) obtained by deprotonation of the phosphate OH groups of 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate; major species at pH 7.3.


An (S)-3-hydroxyacyl-CoA(4-) obtained by deprotonation of the phosphate and diphosphate OH groups of (3S)-3-hydroxyoleoyl-CoA; major species at pH 7.3.


An oxo monocarboxylic acid anion that is the conjugate base of 12-deoxynogalonic acid, obtained by deprotonation of the carboxy group. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


cardiolipin 70:3(2-)

A cardiolipin(2-) derivative in which the four phosphatidyl acyl groups contain a total of 70 carbons and 3 double bonds.


A tricarboxylic acid trianion that is the conjugate base of aconitic acid.


A doubly-charged organosulfate oxoanion arising from deprotonation of the sulfate OH groups of 6-O-sulfo-beta-D-glucosyl-(1->3)-[6-O-sulfo-beta-D-glucosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->6)]-N-acetyl-beta-D-galactosamine


pentacosanoate

A straight-chain saturated fatty acid anion that is the conjugate base of pentacosanoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


An alpha-amino-acid anion that is the conjugate base of piperazine-2-carboxylic acid.


A 1-acyl-sn-glycerol 3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of 1-linoleoyl-sn-glycero-3-phosphate.


3-oxo fatty acid anion

An oxo fatty acid anion obtained by deprotonation of the carboxy group of any 3-oxo fatty acid.


12-dehydro-leukotriene B4(1-)

An icosanoid anion that is the conjugate base of 12-dehydro-leukotriene B4, obtained by deprotonation of the carboxy group; major species at pH 7.3.


An organophosphate oxoanion obtained by deprotonation of the diphosphate OH groups of 8-oxo-dADP.


An acyl-CoA oxoanion obtained by deprotonation of the phosphate, diphosphate and carboxy groups of any omega-carboxyacyl-CoA; major species at pH 7.3.


A 3-hydroxy fatty acyl-CoA(4-) obtained by deprotonation of the phosphate and diphosphate OH groups of (3R,11Z,14Z,17Z)-3-hydroxyicosatrienoyl-CoA; major species at pH 7.3.


An anionic unsymmetrical C7 cyanine dye having substituted indoleinine and benzo[e]indoleinine groups at either end.


Tetraanion of 4-hydroxyphenylacetyl-CoA arising from deprotonation of phosphate and diphosphate functions; major microspecies at pH 7.3


A saturated fatty acyl-CoA(4-) arising from deprotonation of the phosphate and diphosphate functions of isoheptadecanoyl-CoA. Major species at pH 7.3.


lipid IIA(2-)

The lipid oxoanion formed from lipid IIA by deprotonation of the phosphate hydroxy groups and protonation of the amino group. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


2-hydroxy-fatty acyl-CoA(4-)

A fatty acyl-CoA that is hydroxylated at position 2 of the acyl chain, major species at pH 7.3.


A HETE anion that is the conjugate base of 7-HETE, obtained by deprotonation of the carboxy group; major species at pH 7.3.


N-acetyl-L-glutaminate

An N(2)-acetylglutaminate that has L-configuration; major species at pH 7.3.


An organophosphate oxoanion obtained by deprotonation of the diphosphate OH groups of any ditrans,polycis-polyprenyl diphosphate; major species at pH 7.3.


A UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate(4-) in which the muramoyl moiety has alpha-configuratijon at its anomeric centre; major species at pH 7.3


Dianion of UDP-D-apiose arising from deprotonation of both OH groups of the diphosphate.


3-hydroxy fatty acid anion

A hydroxy fatty acid anion obtained by deprotonation of the carboxy group of any 3-hydroxy fatty acid.


A carbohydrate acid derivative anion that is the conjugate base of 2-O-[alpha-D-mannosyl-(1->2)-alpha-D-glucosyl]-D-glyceric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of 17alpha-(N-acetyl-D-glucosaminyl)estradiol 3-glucosiduronic acid; major species at pH 7.3.


A carbohydrate acid derivative anion arising from deprotonation of the carboxy and phosphate OH groups of (2xi)-3-deoxy-7-O-phospho-beta-D-threo-hept-6-ulopyranosonic acid; major species at pH 7.3.


Conjugate base of (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid.


sinapoyl (S)-malate(2-)

Dicarboxylate anion of sinapic acid (S)-malate ester


cardiolipin 64:3(2-)

A cardiolipin(2-) derivative in which the four phosphatidyl acyl groups contain a total of 64 carbons and 3 double bonds.


A hydroperoxydocosapentaenoate that is the conjugate base of (4Z,7Z,10Z,13Z,15E,17S)-17-hydroperoxydocosapentaenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A precorrin carboxylic acid anion obtained by global deprotonation of the carboxy groups of cobalt-precorrin-8.


A phenolate anion that is the conjugate base of catechol.


An organophosphate oxoanion obtained by deprotonation of the diphosphate OH groups of 5alpha,9beta,10alpha-labda-8(20),13-dien-15-yl diphosphate.


phosphatidylserine 28:5(1-)

A 3-sn-phosphatidyl-L-serine(1-) in which the acyl groups at C-1 and C-2 contain 28 carbons in total and 5 double bonds.


(E)-thiourocanate thione form

Major microspecies at pH 7.3


A polyunsaturated fatty acyl-CoA(4-) arising from deprotonation of the phosphate and diphosphate OH groups of (2E,5E)-tetradecadienoyl-CoA; major species at pH 7.3.


A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of GTP; major species present at pH 7.3.


An N-acyl-(3-O-sulfo-D-galactosyl)sphingosine(1-) in which the ceramide N-acyl group is composed of 24 carbons and 2 double bonds.


A 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate resulting from the deprotonation of the carboxy group of 3beta-hydroxy-4alpha-methyl-5alpha-cholesta-8,24-diene-4beta-carboxylic acid. The major species at pH 7.3.


An octadecenoyl-CoA(4-) arising from deprotonation of the phosphate and diphosphate functions of trans-9-octadecenoyl-CoA; major species at p 7.3.


carbovir diphosphate(3-)

An organophosphate oxoanion that is the trianion of carbovir diphosphate, arising from deprotonation of the diphosphate OH groups; major species at pH 7.3.


A conjugate base of 1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-sn-glycerol).


glycolate

A hydroxy monocarboxylic acid anion that is acetate where the methyl group has been hydroxylated.


A polyunsaturated fatty acyl-CoA(4-) in which the S-acyl moiety contains 18 carbons and 2 double bonds at unknown positions. Major species at pH 7.3.


L-gulonate

The L-enantiomer of gulonate.


An organic anion obtained by deprotonation of the two hydroxy groups of pulcherriminic acid; major species at pH 7.3.


An organophosphate oxoanion arising from deprotonation of both free diphosphate OH groups of alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol; major species at pH 7.3.


A 2',3'-dideoxyribonucleoside triphosphate oxoanion obtained from 2',3'-dideoxythymidine triphosphate by deprotonation of three of the four free triphosphate OH groups; major species at pH 7.3.


A mannosylinositol phosphorylceramide(1-) having an acyl group attached to the ceramide nitrogen and hydroxylation at C4 of the C20 sphingoid base; major species at pH 7.3.


A 3-hydroxy fatty acid anion that is the conjugate base of 3-hydroxytetradecanoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A peptide anion obtained by deprotonation of the terminal and side-chain carboxy groups and protonation of the terminal amino group of Asp-Gly; major species at pH 7.3.


An organophosphate oxoanion obtained by deprotonation of the phosphate OH groups of tritrans,heptacis-undecaprenyl phosphate; major species at pH 7.3.


cardiolipin 84:18(2-)

A cardiolipin(2-) derivative in which the four phosphatidyl acyl groups contain a total of 84 carbons and 18 double bonds.


The anion of (R)-2-hydroxy-4-methylpentanoic acid.


kaempferol 3-O-beta-D-galactoside(1-)

An organic anion obtained by selective deprotonation of the 7-hydroxy group of kaempferol 3-O-beta-D-galactoside; major species at pH 7.3.


A 2,3-dehydroacyl-CoA(4-) arising from deprotonation of phosphate and diphosphate functions of pent-2-enoyl-CoA; major species at pH 7.3.


A steroid acid anion that is the conjugate base of (25S)-dafachronic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


An organic anion that is the conjugate base of novobiocin.


A hydroxy fatty acid anion that is the conjugate base of 10,13-dihydroxyoctadecanoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


The oxo dicarboxylate dianion that is hex-3-enedioate oxo-substituted at C-2; the stereochemistry of the C=C double bond is unspecified.


A dTDP-6-deoxy-L-talose(2-) in which the anomeric centre of the pyranose fragment has beta-configuration.


steroid phosphate oxoanion

An organophosphate oxoanion obtained by the deprotonation of one or more oxygen atoms of the phosphate group(s) of a steroid phosphoric acid.


An alpha-amino-acid anion that is the conjugate base of aspartic acid.


A 2-hydroxy fatty acid anion that is the conjugate base of 2-hydroxyerucic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


An acyl-CoA(4-) arising from deprotonation of the phosphate and diphosphate functions of nonadecanoyl-CoA.


UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alaninate(3-) in which the anomeric centre of the pyranose fragment has alpha-configuration.


A mannosylinositol phosphorylceramide(1-) having a tetracosanoyl group attached to the ceramide nitrogen, with hydroxylation at C-2 of the very-long-chain fatty acid.


A peptide anion obtained from the deprotonation of the two carboxy groups, and protonation of the primary amino group of neocasomorphin. It is the major species at pH 7.3.


A naphthoate that is the conjugate base of 3-methoxy-5-methyl-1-naphthoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


Any steroid acid anion obtained by deprotonation of the 4beta-carboxy group of a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylic acid.


Ins-1-P-Cer B/B' 34:0(1-)

An Ins-1-P-Cer B/B'(1-) in which the acyl group and the ceramide base contain a total of 34 carbons and 0 double bonds, and in which either the acyl group is hydroxylated at position 2 or the ceramide base is hydroxylated at position 4.


A steroidal acyl-CoA(4-) resulting from the removal of all four protons from the phosphate groups of chenodeoxycholoyl-CoA. Major species at pH 7.3.


An anionic phospholipid obtained by deprotonation of the free phosphate OH groups of any inositol phosphomannosylinositol phosphophytoceramide. R1 varies with different sphingoid bases, and R2 varies with different fatty acyl moieties.


A monocarboxylic acid anion that is the conjugate base of N-[(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-icosatetraenoyl]-gamma-aminobutanoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A bromobenzoate that is the conjugate base of 4-bromobenzoic acid; major microspecies at pH 7.3.


A dicarboxylic acid monoanion that is the conjugate base of O-hexadecanedioyl-L-carnitine; major spoecies at pH 7.3.


A hydroxy fatty acid ascaroside anion that is the conjugate base of oscr#21, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A polyunsaturated fatty acid anion that is the conjugate base of (4Z,7Z,10Z,13Z,16Z,19Z)-22-hydroxydocosahexaenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


An anionic phospholipid obtained by deprotonation of the free carboxy group of 1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine; major species at pH 7.3.


A 2-hydroxyglutaryl-CoA(5-) that results from the removal of all five protons from the phosphate and carboxylic acid groups of (R)-2-hydroxyglutaryl-CoA; major species at pH 7.3.


Conjugate base of N(1)-(5-phospho-D-ribosyl)glycinamide.


quillate

A monocarboxylic acid anion that is the conjugate base of quillaic acid, resulting from the deprotonation of the carboxy group; Major species at pH 7.3.


prostaglandin H3(1-)

A prostaglandin carboxylic acid anion that is the conjugate base of prostaglandin H3, obtained by deprotonation of the carboxy group; major species at pH 7.3.


jasmonic acid anion

A 5-oxo monocarboxylic acid anion obtained by deprotonation of the carboxy group of any diastereomer of jasmonic acid; major species at pH 7.3.


An anionic unsymmetrical C5 cyanine dye having differentially substituted indoleinine units at either end.


A doubly-charged N-acyl-L-alpha-amino acid anion resulting from deprotonation of both carboxy groups of N-formyl-L-glutamic acid.


Cy3-bifunctional dye(1-)

An organosulfonate oxoanion that is the conjugate base of Cy3-bifunctional dye zwitterion.


A polyunsaturated fatty acid anion that is the conjugate base of 10-HPO(6,8,12)TrE, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A organosulfate oxoanion and monocarboxylic acid anion that results from the removal of a proton from both the carboxy group and the sulfate group of 4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc. The major species at pH 7.3.


A D-alpha-amino acid anion which is obtained from (3R)-3-hydroxy-D-aspartic acid by formal deprotonation of both carboxyl groups and protonation of the amino group.


histidinate derivative

A carboxylic acid anion which is a conjugate base of  a histidine derivative  having either D- or L-configuration.


An organophosphate oxoanion obtained by removal of the proton from the phosphate group of L-threonyl-AMP.


A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of (3R,5S)-fluvastatin.


A dicarboxylic acid dianion obtained by deprotonation of the carboxy groups of (-)-DCA-CC; major species at pH 7.3.


A dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxylic acid groups of ethylmalonic acid.


An L-amino acid anion, being the conjugate base of L-3-oxoalanine.


An N-acyl-(2S)-hydroxyglycinate that is the conjugate base of N-(9Z-octadecenoyl)-(2S)-hydroxyglycine, obtained by deprotonation of the carboxy group; major species at pH 7.3.


hexadecatrienoate

A polyunsaturated fatty acid anion obtained by deprotonation of the carboxy group of any hexadecatrienoic acid; major species at pH 7.3.


A ganglioside GD1(2-) obtained by deprotonation of the neuraminosyl carboxy groups of alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-Cer; major species at pH 7.3.


An inositol phosphomannosylinositol-1-phosphophytoceramide(2-) obtained by deprotonation of the free phosphate OH group of inositol phosphomannosylinositol-1-phospho-C20-phytoceramide; major species at pH 7.3.


A 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of 1-oleoyl-2-stearoyl-sn-glycero-3-phosphate.


An organophosphate oxoanion obtained by deprotonation of the phosphate OH groups of 2'-3'-cGAMP; major species at pH 7.3.


cardiolipin 76:8(2-)

A cardiolipin(2-) derivative in which the four phosphatidyl acyl groups contain a total of 76 carbons and 8 double bonds.


A docosanoid anion that is the conjugate base of (7S,17S)-bis(hydroperoxy)-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.


A carbohydrate acid derivative anion arising from deprotonation of the carboxy groups and protonation of the amino group of GlcNAc-1,6-anhMurNAc-pentapeptide; major species at pH 7.3.


oxidized Renilla luciferin(1-)

An organic anion obtained by deprotonation of the amide group of oxidized Renilla luciferin. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


norsolorinic acid anthrone(1-)

A phenolate anion obtained by deprotonation of the 2-hydroxy group of norsolorinic acid anthrone. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


name: NDUB2_ARATH NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2 (sprot)

description: A protein that is a translation product of the At1g76200 gene in Arabidopsis thaliana.


name: PNMA2_MOUSE Paraneoplastic antigen Ma2 homolog (sprot)

description: A paraneoplastic antigen Ma2 that is encoded in the genome of mouse.


paraneoplastic antigen Ma2

A protein that is a translation product of the human PNMA2 gene or a 1:1 ortholog thereof.


name: paraneoplastic antigen Ma2, initiator methionine removed form

description: A paraneoplastic antigen Ma2 that has had the initiator methionine removed.


name: PNMA2_HUMAN Paraneoplastic antigen Ma2 (sprot)

description: A paraneoplastic antigen Ma2 that is encoded in the genome of human.


A tetrasaccharide comprising three alpha-D-mannose residues, all linked (1->2), with a beta-D-galactose residue also linked (1->4) to the reducing-end mannose residue. A Leishmania lipophosphoglycan capping tetrasaccharide.


A 2-hydroxy-6-oxonona-2,4,7-trienedioic acid having (2Z,4E,7E)-configuration.


name: transcriptional regulator ATRX sequence variant Q176* (human)

description: A transcriptional regulator ATRX (human) that has has been truncated after the position equivalent to Gly-175 of the amino acid sequence represented by UniProtKB:P46100-1. Example: UniProtKB:P46100-1, 1-175.


A protein that is a translation product of the gma12 gene in Schizosaccharomyces pombe 972h-.


An N-glycosyldihydrozeatin consisting of dihydrozeatin carrying two alpha-D-glucosyl on the oxygen and the nitrogen at position 9 in the purine ring.


name: UVRC_CLOBH UvrABC system protein C (sprot)

description: A UvrABC system protein C that is encoded in the genome of Clostridium botulinum A str. Hall.


UvrABC system protein C

A protein that is a translation product of the Escherichia coli K-12 uvrC gene or a 1:1 ortholog thereof.


name: UVRC_ECOLI UvrABC system protein C (sprot)

description: A UvrABC system protein C that is encoded in the genome of Escherichia coli K-12.


An inositol phosphomannosylinositol phosphoceramide  compound having an inositol 1-phosphoryl group linked to the mannose residue (at the 6-position) and a hexacosanoyl group amide-linked to a C20 phytosphingosine base, with hydroxylation at C-2 of the C26 very-long-chain fatty acid.


name: non-homologous end-joining factor 1 isoform m2 (mouse)

description: A non-homologous end-joining factor 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3KNJ2-2.


(2E)-HEXENOIC ACID

The (E)-stereoisomer of hexenoic acid.


protein AAR2 homolog isoform 1

A protein AAR2 homolog that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y312-1 or a 1:1 ortholog thereof.


protein AAR2 homolog isoform 1 (mouse)

A protein AAR2 homolog isoform 1 that is encoded in the genome of mouse.


protein AAR2 homolog isoform 1 (human)

A protein AAR2 homolog isoform 1 that is encoded in the genome of human.


protein KIBRA phosphorylated 1 (human)

A protein KIBRA (human) that has been phosphorylated on the residue at the position equivalent to Ser-539 of the amino acid sequence represented by UniProtKB:Q8IX03-1. Example: UniProtKB:Q8IX03-1, Ser-539, MOD:00046.


KIBRA_HUMAN Protein KIBRA (sprot)

A protein WWC1 that is encoded in the genome of human.


protein KIBRA isoform h2 (human)

A protein KIBRA (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IX03-2.


protein KIBRA isoform h1 (human)

A protein KIBRA (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IX03-1.


A secondary fatty alcohol that is tricosane substituted by a hydroxy group at position 5.


name: RBT1_CANAL Cell wall protein RBT1 (sprot)

description: A protein that is a translation product of the RBT1 gene in Candida albicans SC5314.


name: GRC3_CANAL Polynucleotide 5'-hydroxyl-kinase GRC3 (sprot)

description: A protein that is a translation product of the GRC3 gene in Candida albicans SC5314.


uncharacterized protein YgcP

A protein that is a translation product of the Escherichia coli K-12 ygcP gene or a 1:1 ortholog thereof.


name: YGCP_ECOLI Uncharacterized protein YgcP (sprot)

description: An uncharacterized protein YgcP that is encoded in the genome of Escherichia coli K-12.


name: fibrinogen gamma chain, signal peptide removed form (human)

description: A fibrinogen gamma chain (human) that has had the signal peptide removed. UniProtKB:P02679, 27-453.


A 2-dodecene that is dodecane which has been dehydrogenated to introduce a trans double bond between positions 2 and 3.


A dodecene that is dodecane with a double bond at position 2.


A 2-dodecene that is dodecane which has been dehydrogenated to introduce a cis double bond between positions 2 and 3.


name: histone-lysine N-methyltransferase PRDM9 isoform m1 (mouse)

description: A histone-lysine N-methyltransferase PRDM9 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96EQ9-1.


TAL1_SCHPO Transaldolase (sprot)

A transaldolase that is encoded in the genome of Schizosaccharomyces pombe 972h-.


name: sperm-associated antigen 1 isoform m1 (mouse)

description: A sperm-associated antigen 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80ZX8-1.


name: SPAG1_MOUSE Sperm-associated antigen 1 (sprot)

description: A sperm-associated antigen 1 that is encoded in the genome of mouse.


name: sperm-associated antigen 1 isoform m2 (mouse)

description: A sperm-associated antigen 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80ZX8-2.


name: sperm-associated antigen 1 isoform m3 (mouse)

description: A sperm-associated antigen 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q80ZX8-3.


name: transcription factor AP-2 gamma isoform h2 (human)

description: A transcription factor AP-2 gamma (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92754-2.


name: inositol 1,4,5-triphosphate receptor associated 1 isoform 1 phosphorylated 1 (human)

description: An inositol 1,4,5-triphosphate receptor associated 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6F6-1, Ser-657/Ser-670, MOD:00046.


name: inositol 1,4,5-triphosphate receptor associated 1 isoform 1

description: An inositol 1,4,5-triphosphate receptor associated 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6F6-1 or a 1:1 ortholog thereof.


name: inositol 1,4,5-triphosphate receptor associated 1 isoform 1 phosphorylated 1

description: An inositol 1,4,5-triphosphate receptor associated 1 isoform 1 that has been phosphorylated by PKG1. Example: UniProtKB:Q9Y6F6-1, Ser-657/Ser-670, MOD:00046.


name: inositol 1,4,5-triphosphate receptor associated 1 isoform 1 (human)

description: An inositol 1,4,5-triphosphate receptor associated 1 isoform 1 that is encoded in the genome of human.


otoferlin deaminated 1 (human)

An otoferlin (human) that has been deaminated on the residue at the position equivalent to Asn-1082 of the amino acid sequence represented by UniProtKB:Q9HC10-1. Example: UniProtKB:Q9HC10-1, Asn-1082, MOD:00684.


name: tyrosyl-tRNA synthetase isoform 1, initiator methionine removed acetylated 1 (Escherichia coli K-12)

description: A tyrosyl-tRNA synthetase isoform 1, initiator methionine removed acetylated 1 in Escherichia coli K-12. UniProtKB:P0AGJ9-1, 2-424, Lys-144, MOD:00064.


name: tyrosyl-tRNA synthetase, initiator methionine removed form

description: A tyrosyl-tRNA synthetase that has had the initiator methionine removed.


name: tyrosyl-tRNA synthetase isoform 1, initiator methionine removed form

description: A tyrosyl-tRNA synthetase isoform 1 that has had the initiator methionine removed.


name: tyrosyl-tRNA synthetase isoform 1, initiator methionine removed acetylated 1

description: A tyrosyl-tRNA synthetase isoform 1, initiator methionine removed form that has been acetylated at the position equivalent to Lys-144 of the amino acid sequence represented by UniProtKB:P0AGJ9-1. Example: UniProtKB:P0AGJ9-1, 2-424, Lys-144, MOD:00064.


name: glycosylated lysosomal membrane protein cysteinylated 1 (human)

description: A glycosylated lysosomal membrane protein (human) that has been cysteinylated on the residue at the position equivalent to Cys-330 of the amino acid sequence represented by UniProtKB:Q8WWB7-1. Example: UniProtKB:Q8WWB7-1, Cys-330, MOD:00765.


H11_ARATH Histone H1.1 (sprot)

A protein that is a translation product of the At1g06760 gene in Arabidopsis thaliana.


name: ARID4_ARATH AT-rich interactive domain-containing protein 4 (sprot)

description: A protein that is a translation product of the ARID4 gene in Arabidopsis thaliana.


Grade 5 Ureter Obstruction, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


microcytic anemia

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Anemia in which the red blood cell volume is decreased.


Increased HbA2 hemoglobin

description: An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia.


Myelokathexis

description: Impaired egress of mature neutrophils from bone marrow causing neutropenia.


Absent platelet dense granules

description: Lack of platelet dense granules, a type of platelet organelles.


name: Increased proportion of CD25+ mast cells

description: An increased proportion of mast cells are positive for the cell surface marker CD25 (also called interleukin-2 receptor alpha chain).


Abnormal macrophage count

description: An anomaly in the number of macrophages.


name: Abnormal erythrocyte UDP glucose-4-epimerase concentration

description: An abnormality in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.


Amegakaryocytic thrombocytopenia

description: Thrombocytopenia related to lack of or severe reduction in the count of megakaryocytes.


name: fetal and neonatal alloimmune thrombocytopenia

description: Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies. NAIT was first reported in the literature in 1953 and is estimated to occur in as many as 1 in 1200 live births. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother's platelets and those of the baby. Certain molecules (antigens) on the surface of the baby's platelets are recognized as foreign by the mother's immune system. The mother's immune system then creates antibodies that attack and destroy the baby's platelets. Though NAIT can occur whenever the mother's blood mixes with that of the baby, it is usually triggered when the mother is exposed to the baby's blood during delivery. Many cases of NAIT are mild. Signs and symptoms may include a low platelet count (thrombocytopenia) and signs of bleeding into the skin such as petechiae and purpura. In the most severe cases, NAIT can cause bleeding episodes that may result in death or long-term disability. Bleeding episodes can occur either during pregnancy or after birth. Management of the infant with neonatal alloimmune thrombocytopenia may include platelet transfusions, ultrasounds, and intravenous immunoglobulin (IVIG). Treatment for pregnant mothers at risk for NAIT may include IVIG and steroids.


Decreased hemoglobin concentration

description: An abnormal reduction below normal hemoglobin concentration in the circulation.


Increased Burr cell count

description: Burr cells, also known as echinocytes, have a speculated border over the entire cell surface. Burr cells are commonly found in both end-stage renal disease and liver disease. Small numbers of Burr cells are commonly found in healthy individuals.


Hyperchromic macrocytic anemia

description: A type of anemia characterized by abnormally large erythrocytes with abnormally high amounts of hemoglobin.


Abnormal neutrophil count

description: A deviation from the normal range of neutrophil cell counts in the circulation.


Low neutrophil alkaline phosphatase

description: An abnormally reduced level of alkaline phosphatase in neutrophils, which could be due to absence of enzyme or the production of defective enzyme.


Congenital thrombocytopenia

description: Thrombocytopenia with congenital onset.


autoimmune thrombocytopenia

description: An autoimmune form of thrombocytopenia.


Infection associated neutropenia

description: Transient neutropenia caused by an infection, such as with a virus, bacteria or protozoan.


name: myelodysplastic syndrome with ring sideroblasts

description: Acquired idiopathic sideroblastic anemia is one of a group of disorders known as the myelodysplastic syndromes (MDS) characterized by ineffective haemopoiesis affecting one or more blood cell lineages (myeloid, erythroid or megakaryocytic) leading to peripheral blood cytopenias and an increased risk of developing leukemia. Acquired idiopathic sideroblastic anemia is now more commonly referred to as refractory anemia with ringed sideroblasts or the acronym RARS.


Increased circulating myelocyte count

description: The number of myelocytes in the peripheral blood circulation is above the upper limit of normal. Myelocytes are immature neutrophils with a size of 12-18 micrometers, a round or oval nucleus with no nucleoli, bluish-pink staining cytoplasm with primary and secondary granules, and a nucleus:cytoplasm ratio of 2:1.


Anemia of inadequate production

description: A kind of anemia characterized by inadequate production of erythrocytes.


Reduction of neutrophil motility

description: An abnormal reduction of the cell motility of neutrophils.


Giant neutrophil granules

description: The presence of abnormally large granules in neutrophils. This finding can be appreciated on a peripheral blood smear. The finding is characteristic of Chediak Higashi syndrome. The giant granules are derived from azurophil granules, whereas peroxidase-negative granules are not involved in their formation.


Transient neutropenia

description: A transient reduction in the number of neutrophils in the peripheral blood. Transient neutropenia is most commonly associated with viral infections, but other causes include drugs and autoimmunity.


name: Decreased erythrocyte UDP glucose-4-epimerase concentration

description: A decrease in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.


Abnormal hematocrit

description: Any deviation from the normal ratio of the volume of red blood cells to the total volume of blood.


Cold-induced hemolysis

description: A form of hemolytic anemia that can be triggered by cold temperatures.


hemoglobin H disease

description: Alpha thalassemia caused by variation in three of the four copies of the alpha hemoglobin genes (e.g., large deletion in HBA1 and HBA2 genes in trans with a variant in either HBA1 or HBA2).


Abnormal granulocyte morphology

description: Any structural abnormality or abnormal count of granulocytes.


Hemophagocytosis

description: Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues.


Abnormal proerythroblast morphology

description: Anomalous form of the proerythroblast, i.e., the immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.


Abnormality of neutrophil physiology

description: A functional abnormality of neutrophils.


Megaloblastic erythroid hyperplasia

description: A laboratory test result indicating an abnormally high quantity of abnormal immature red blood cells with megaloblastic features.


normocytic anemia

description: Anemia in which the red blood cell volume is normal.


Leukocyte inclusion bodies

description: The presence of intraceullar inclusion bodies (aggregates of stainable substances, usually proteins) in leukocytes.


Hepatic granulomatosis

description: The presence of multiple granulomas in the liver as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes.


Hepatic mastocytosis

description: Liver mast cell infiltration.


Granulocytosis

description: An increased count of granulocytes in the peripheral blood circulation.


Megaloblastic bone marrow

description: Abnormal increased number of megaloblasts in the bone marrow.


Chronic hemolytic anemia

description: An chronic form of hemolytic anemia.


Enlarged platelet dense granules

description: Increased size of platelet dense granules.


Abnormal basophil count

description: Any deviation from the normal number of basophils per volume in the blood circulation.


Abnormal dense granule content

description: A deviation from the normal contents of the platelet alpha granules, which normally contain adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin, calcium, and pyrophosphate, which are secreted when platelets are activated.


Increased neutrophil ribosomes

description: An increased number of ribosomes detected in neutrophils.


name: Elevated erythrocyte inosine triphosphate concentration

description: Concentration of inosine triphosphate in red blood cells is above the upper limit of normal.


Bone marrow hypocellularity

description: A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.


Bone marrow monocytosis

description: Increased count of monocytes in the bone marrow.


Abnormal dense tubular system

description: An anomaly of the intracellular membrane complexes known as the dense tubular system.


Drug-induced agranulocytosis

description: A type of agranulocytosis related to ingestion of a specific medication.


description: A type of megaloblastic anemia that does not improve upon administration of folate. Since vitamin B12 acts by promoting recycling of folate, administration of vitamin B12 also does not improve this type of anemia.


Bone marrow vacuolated lymphocytes

description: The presence of lymphocytes with multilple vacuoles (a membrane-bound cell organelle) in the bone marrow.


Increased circulating band cell count

description: The number of band cells in the peripheral blood circulation is above the upper limit of normal. Band cells are immature neutrophils with a size of 10-18 micrometers, a horseshoe-shaped nucleus with no nucleoli, light-pink staining cytoplasm with many small secondary granules, and a nucleus:cytoplasm ratio of 1:2.


Normochromic microcytic anemia

description: A type of anemia characterized by an normal concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes.


name: Reduced erythrocyte 2,3-diphosphoglycerate concentration

description: This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes. 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation.


Abnormal number of erythroid precursors

description: A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.


Reduced beta/alpha synthesis ratio

description: A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia.


name: Bone marrow arrest at the promyelocytic stage

description: A type of bone marrow maturation arrest characterized by accumulation of neutrophil precursor cells in the bone marrow.


name: Abnormal erythrocyte enzyme concentration or activity

description: An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme.


Increased hematocrit

description: An elevation above the normal ratio of the volume of red blood cells to the total volume of blood.


Increased megakaryocyte count

description: Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow.


Reduced platelet alpha granules

description: A reduced number of platelet alpha granules.


Pyknotic bone marrow neutrophils

description: Nuclear lobes of neutrophils in the bone marrow are thickened and condensed, and individual lobes are connected by unusually long chromatin filaments.


hereditary elliptocytosis

description: Hereditary elliptocytosis (HE) is a rare clinically and genetically heterogeneous disorder of the red cell membrane characterized by manifestations ranging from mild to severe transfusion-dependent hemolytic anemia but with the majority of patients being asymptomatic.


Cerebral granulomatosis

description: Cerebral inflammation involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells.


Increased micromegakaryocyte count

description: The presence of abnormally high numbers of micromegakaryocytes in the bone marrow. Micromegakaryocytes are mononuclear diploid cells, with a nucleus similar in size to that of a myeloblast or promyelocyte with the cell being less than 30 micrometers in diameter.


Abnormal platelet count

description: Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood.


Exercise-induced hemolysis

description: A form of hemolytic anemia that can be triggered by exertion.


Reduced erythrocyte hexokinase activity

description: Activity or concentration of hexokinase (EC 2.7.1.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle.


Multinucleated erythroblast

description: Erythroblasts with multiple nuclei. Erythroblasts are nucleated precrusor cells of erythrocytes that are localized to the bone marrow. Normally, erythroblasts have a single nucleus. The abnormal finding of erythrocytes with two or more nuclei may be related to defects in cytokinesis.


Granulocytic hypoplasia

description: Decreased number of granulocyte precursors in the bone marrow.


name: Impaired neutrophil killing of staphylococci

description: A reduction in the ability of neutrophils to kill the gram-positive bacteria, staphylococcus, which is commonly known as staph.


Anisocytosis

description: Abnormally increased variability in the size of erythrocytes.


Abnormal dense granules

description: Defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium, histamine and serotonin.


name: Abnormal platelet dense granule ATP/ADP ratio

description: Deviation from normal of the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) within platelets.


Abnormal granulocyte count

description: Any deviation from the normal cell count per volume of granulocytes in the blood circulation.


Imbalanced hemoglobin synthesis

description: Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia.


Blood group antigen abnormality

description: An abnormality of an erythrocyte cell surface molecule.


Impaired oxidative burst

description: In the NBT test, neutrophils change the colorless compound NBT into a compound with a deep blue color. If this test is negative (i.e., no blue color is produced), then this indicates a defect in superoxide-generating NADPH oxidase activity with inability to efficiently kill phagocytized bacteria.


Bite cells

description: Red blood cells that appear to have parts of them bitten away.


Neutrophil nuclear clefts

description: An abnormality of the nucleus of neutrophils, which presents as either a type I nuclear cleft, where the nuclear cleft may show a transition into a round/oval shape. The second type nuclear cleft, which runs perpendicular to the nuclear surface, and this type of cleft might be related to nuclear lobe formation.


Poikilocytosis

description: The presence of abnormally shaped erythrocytes.


Absent neutrophil specific granules

description: Lack of specific granules in neutrophils.


name: Abnormal mean corpuscular hemoglobin concentration

description: A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.


Abnormal macrophage morphology

description: An abnormality of macrophages.


malakoplakia

description: Malakoplakia is a chronic multisystem granulomatous inflammatory disease characterized by the presence of single or multiple soft plaques on various organs of the body.


Megakaryocyte dysplasia

description: The presence of micro-megakaryocytes, hypo-lobed, or non-lobed nuclei in megakaryocytes of all sizes and multiple, widely-separated nuclei.


Transient erythroblastopenia

description: A transient reduction in the number of erythroblasts in the circulation.


xanthogranuloma

description: A reactive lesion characterized by the presence of a bland histiocytic cellular infiltrate admixed with giant cells.


Decreased mean corpuscular volume

description: A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters).


Abnormal myeloid cell morphology

description: Any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.


name: Increased circulating hemoglobin concentration

description: Concentration of hemoglobin in the blood circulation above the upper limit of normal.


Bone marrow erythroid vacuolization

description: Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of erythroid precursors in the bone marrow.


Heinz bodies

description: A type of erythrocyte inclusion composed of denatured hemoglobin.


Eosinophil nuclear hypersegmentation

description: An excessive division of the lobes of the nucleus of eosinophils. Eosinophils with more than two nuclear lobes are commonly regarded as hypersegmented, because seventy to ninety percent of peripheral blood eosinophils have two nuclear lobes.


Neutrophilia

description: Increased number of neutrophils circulating in blood.


Microspherocytosis

description: The presence of erythrocytes that are sphere-shaped and reduced in size.


Anisopoikilocytosis

description: A type of poikilocytosis characterized by the presence in the blood of erythrocytes of varying sizes and abnormal shapes.


name: Hyposegmentation of neutrophil nuclei in CSF

description: Hyposegmented (hypolobulated) or bilobed neutrophil nuclei in the cerebrospinal fluid.


name: Reduced erythrocyte bisphosphoglycerate mutase activity

description: Activity or concentration of bisphosphoglycerate mutase (BPGM; EC 5.4.2.4;) in red blood cells below the lower limit of normal. BPGM is a multifunctional enzyme specifically found in red blood cells that synthesizes 2,3-diphosphoglycerate through its synthase activity and degrades it through its phosphatase activity.


Episodic eosinophilia

description: Recurrent episodes of marked eosinophilia that resolve spontaneously.


description: A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of thiamine.


name: Reduced erythrocyte uroporphyrinogen III cosynthase activity

description: Activity or concentration of in the level of uroporphyrinogen III (EC 4.2.1.75) in erythrocytes below the lower limit of normal.


Reduced platelet dense granules

description: Decreased number of platelet dense granules, a type of platelet organelle.


Episodic hemolytic anemia

description: A form of hemolytic anemia that occurs in repeated episodes.


name: Increased red cell hemolysis by shear stress


name: Abnormal erythrocyte adenosine deaminase activity

description: Activity of adenosine deaminase in red blood cells outside the limits of normal.


Decreased basophil count

description: An abnormally reduced count of basophils per volume in the blood circulation.


name: Elevated red cell pyruvate kinase activity

description: Activity or concentration of pyruvate kinase (EC 2.7.1.40) in erythrocytes above the upper limit of normal. Pyruvate kinase (EC 2.7.1.40) is a glycolytic enzyme that catalyzes the transphosphorylation from phosphoenolpyruvate (PEP) to ADP, yielding pyruvate and ATP.


name: Abnormal erythrocyte adenosine triphosphate concentration

description: Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) outside of the normal range.


Bone marrow granuloma

description: A granuloma (a focal aggregate of immune cells that forms in response to a persistent inflammatory stimulus) localiyed to the bone marrow. A granuloma characteristically demonstrates the compact organization of mature macrophages, which may or may not be associated with other inflammatory cell types.


Granulomatosis

description: A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.


Abnormal number of dense granules

description: A deviation from the normal count of dense granules per thrombocyte.


Neutrophilia in absence of infection

description: An increased number of neutrophils circulating in the blood in the absence of an infection. Factors contributing to neutrophilia could include inflammation or congenital disorders.


HbS hemoglobin

description: Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a valine (the mutation causative of sickle cell disease). The mutation promotes the polymerization of the HbS under conditions of low oxygen concentration. HbS can be identified by multiple methodologies including hemoglobin electrophoresis and high-performance liquid chromatography.


Abnormal alpha granule content

description: A deviation from the normal contents of the platelet alpha granules, which normally contain hemostatic proteins such as fibrinogen, von Willebrand factor, and growth factors such as platelet-derived growth factor.


description: A type of megaloblastic anemia that improves upon administration of pyrimidine supplements such as uridylic acid and cytidylic acid.


Splenic hemophagocytosis

description: Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the spleen.


Coombs-positive hemolytic anemia

description: A type of hemolytic anemia in which the Coombs test is positive.


name: Elevated erythrocyte galactose-1-phosphate concentration

description: Concentration of galactose-1-phosphate in red blood cells (erythrocytes) above the upper level of normal.


sea-blue histiocyte syndrome

description: A rare, inherited or acquired syndrome characterized by the presence of histiocytes in the bone marrow which contain granules stained blue with hematoxylin-eosin stain, mild thrombocytopenia and purpura, and splenomegaly.


Abnormal microglia morphology

description: An abnormality of the microglial cells. They are also known as brain-resident macrophages or Hortega cells.


name: Increased megakaryocyte colony forming unit count

description: Increased numbers of megakryocyte precursors (megakaryocyte colony forming units) in the bone marrow.


Absent neutrophil lactoferrin

description: The absence of lactoferrin in neutrophil granules, which could be caused by either an isolated failure of synthesis of this protein (or the production of an antigenically unrecognizable form of lactoferrin) or a complete deficiency of specific granule production.


Hypochromia

description: A qualitative impression that red blood cells have less color than normal when examined under a microscope, usually related to a reduced amount of hemoglobin in the red blood cells.


Persistence of hemoglobin F

description: Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.


name: Neutropenia in presence of anti-neutropil antibodies

description: A type of neutropenia that is observed in the presence of granulocyte-specific antibodies.


Drug-sensitive hemolytic anemia

description: A form of hemolytic anemia that is triggered by ingestion of certain drugs.


Neutrophilia in presence of infection

description: An increased number of neutrophils circulating in the blood during an infection, such as with a bacteria, virus or fungus.


Abnormal number of alpha granules

description: A deviation from the normal count of alpha granules per thrombocyte.


Increased RBC distribution width

description: Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.


Erythroid hypoplasia

description: Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.


name: Anemia due to reduced life span of red cells

description: A type of anemia related to a reduction in the average life span of red blood cells in the peripheral circulation, which is normally around 120 days.


Megakaryocyte nucleus hypolobulation

description: The presence of megakaryocytes in the bone marrow whose nuclei are less lobulated than expected for the size of the nucleus.


Red blood cell keratocytosis

description: A form of poikilocytosis in which the abnormally shaped erythrocytes have notches that results in projections that look like horns.


Erythroid hyperplasia

description: Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.


Increased red blood cell mass

description: The presence of an increased mass of red blood cells in the circulation.


Abnormal alpha granules

description: Defective structure, size or content of alpha granules, platelet organelles that contain several growth factors destined for release during platelet activation at sites of vessel wall injury.


Bone marrow maturation arrest

description: Interruption of the procecss of diffferentiation of hematopoietic cells in the bone marrow, manifested by an increased proportion of immature cells in the bone marrow.


Abnormal megakaryocyte morphology

description: Any structural anomaly of megakaryocytes. Mature blood platelets are released from the cytoplasm of megakaryocytes, which are bone-marrow resident cells.


name: Elevated red cell adenosine deaminase activity

description: Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.


Reduced hematocrit

description: A reduction below the normal ratio of the volume of red blood cells to the total volume of blood.


Post-transfusion thrombocytopenia

description: Sudden onset of thrombocytopenia (reduced platelet count) within 5-10 days of the transfusion of blood products. The clinical presentation is post-transfusion purpura (PTP), wigth severe thrmbocytopenia, epistaxis, and hemorrhages.


Abnormal alpha granule distribution

description: An anomalous location and arrangement of platelet alpha granules.


name: Reduced erythrocyte glutathione concentration

description: Concentration of glutathione in red blood cells below the lower limit of normal. Glutathione (GSH) is an important redox active biomolecule critical in the maintenance and regulation of cellular and organismal health.


name: Elevated erythrocyte adenosine triphosphate concentration

description: Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) above the upper limit of normal.


Bone-marrow foam cells

description: The presence of foam cells in the bone marrow, generally demonstrated by bone-marrow aspiration or biopsy. Foam cells have a vacuolated appearance due to the presence of complex lipid deposits, giving them a foamy or soap-suds appearance.


Urinary bladder granulomatosis

description: The presence of multiple granulomas in the urinary bladder as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes.


Abnormal mean corpuscular volume

description: A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.


Abnormal mast cell morphology

description: Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation.


megaloblastic anemia, folate-responsive

description: A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of folate.


name: Decreased mean corpuscular hemoglobin concentration

description: A reduction from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.


Erythrocyte inclusion bodies

description: Nuclear or cytoplasmic aggregates of substances in red blood cells.


Spherocytosis

description: The presence of erythrocytes that are sphere-shaped.


Abnormal L-selectin shedding

description: An abnormality in the cleavage of L-selectin during the process of guiding neutrophils to the site of infection. Proteolytic cleavage of L-selectin results in rapid shedding from the cell surface, which has a role in neutrophil rolling and accumulation at the site of infection.


Chronic neutropenia

description: Neutropenia with an absolute neutrophil count (ANC) less than 1,500,000,000/L lasting for more than 3 months.


name: Abnormality of bone marrow stromal cells


Abnormal eosinophil count

description: Any deviation from the normal number of eosinophils per volume in the blood circulation.


cyclic hematopoiesis

description: A hematologic disorder caused by a mutation in the ELANE (ELA2) gene; clinical manifestations include recurrent neutropenia with resultant susceptibility to infection leading to fever.


Abnormal neutrophil morphology

description: An abnormal form or size of neutrophils.


name: Hypersegmentation of neutrophil nuclei in CSF

description: An excessive division of the lobes of the nucleus of a neutrophil in the cerebrospinal fluid.


Lipid-laden bone-marrow macrophages

description: Bone marrow with increased numbers of macrophages heavily laden with lipids.


Abnormal monocyte count

description: An anomaly in the number of monocytes, which are myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.


name: Increased neutrophil nuclear projections

description: Presence of an elevated number of projections from nuclei of neutrophils. These projections can have the shape of hooks, tags, or clubs.


Elevated hemoglobin A1c

description: An increased concentration of hemoglobin A1c (HbA1c), which is the product of nonenzymatic attachment of a hexose molecule to the N-terminal amino acid of the hemoglobin molecule. This reaction is dependent on blood glucose concentration, and therefore reflects the mean glucose concentration over the previous 8 to 12 weeks. The HbA1c level provides a better indication of long-term glycemic control than one-time blood or urinary glucose measurements.


Acanthocytosis

description: Acanthocytosis is a type of poikilocytosis characterized by the presence of spikes on the cell surface. The cells have an irregular shape resembling many-pointed stars.


name: Reduced erythrocyte porphobilinogen deaminase activity

description: Activity or concentration of in the level of porphobilinogen deaminase (EC 4.3.1.8) in erythrocytes below the lower limit of normal.


name: Diminished neutrophil myeloperoxidase activity

description: Activity of the enzyme myeloperoxidase (EC 1.11.1.7) in neutrophils below the lower limit of normal. This feature can be measured by peroxidase cytochemistry or biochemical assays. Myeloperoxidase is a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear leukocytes and monocytes.


Mucinous histiocytosis

description: Multiple subcutaneous non-fragile and skin-coloured papules characterized by interstitial infiltrate of spindle and epithelioid histiocytes, and mucin. There are well circumscribed aggregates of epithelioid histiocytes and mucin in the upper and middle dermis,with the histiocytes arranged between collagen bundles and separated from the epidermis by a Grenz zone.


name: Abnormality of neutrophil morphology in CSF

description: An abnormal form or size of neutrophils in the cerebrospinal fluid.


Impaired neutrophil chemotaxis

description: An impairment of the migration of neutrophils towards chemoattractants as part of the innate immune response


Circulating nucleated red blood cells

description: The presence of nucleated red blood cells in the peripheral blood circulation.


name: Non-caseating epithelioid cell granulomatosis

description: The presence of multiple epithelioid cell granulomas consist of highly differentiated mononuclear phagocytes (epithelioid cells and giant cells) and lymphocytes, not exhibiting caseation (a form of necrosis in which the tissue changes into a dry, amorphous mass said to resemble cheese).


Abnormal platelet granules

description: An anomaly of alpha or dense granules or platelet lysosomes.


name: Abnormal granulocytopoietic cell morphology

description: An anomaly of cells involved in the formation of a granulocytes, that is, of the granulocytopoietic cell.


Intermittent thrombocytopenia

description: Reduced platelet count that occurs sporadically, i.e., it comes and goes.


name: Reduced erythrocyte galactose-1-phosphate uridylyltransferase activity

description: Activity or concentration of in the level of galactose-1-phosphate uridylyltransferase (GALT; EC 2.7.7.12) in erythrocytes below the lower limit of normal.


Steroid-responsive anemia

description: Amelioration of anemia upon treatment with a steroid medication.


Stomatocytosis

description: The presence of erythrocytes with a mouth-shaped (stoma) area of central pallor on peripheral blood smear.


Rouleaux formation

description: Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells.


name: Abnormality of multiple cell lineages in the bone marrow


Abnormal erythrocyte morphology

description: Any structural abnormality of erythrocytes (red-blood cells).


Monocytosis

description: An increased number of circulating monocytes.


Gastrointestinal granulomatosis

description: The presence of multiple granulomas in the gastrointestinal tract (Pylorus, esophagus, jejunum, ileum, cecum, rectum, perirectal area, esophagus) as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes.


name: Reduced erythrocyte adenosine triphosphate concentration

description: Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) below the lower limit of normal.


Abnormal basophil morphology

description: Any structural abnormality or abnormal count of basophils.


Giant platelets

description: Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. The term giant platelet is used when the platelet is larger than the size of the average red cell in the field. (Description adapted from College of American Pathologists, Hematology Manual, 1998).


Refractory sideroblastic anemia

description: A type of sideroblastic anemia that is not responsive to treatment.


Increased urine neutrophil count

description: Abnormally increased count of neutrophils in urine.


Polychromasia

description: Increased variation in the color of the erythrocytes (red blood cells), including pale red, normal or dark colors, indicating a highly variable hemoglobin concentration. Typically this indicates the release of immature erythrocytes in states of anemia.


Decreased eosinophil count

description: Abnormal reduction in the count of eosinophils in the blood per volume.


name: Abnormal surface-connected open canalicular system

description: An anomaly of the invaginations of the surface membrane that form the open canalicular system (OCS). The OCS serve as the pathway for transport of substances into the cells and as conduits for the discharge of alpha granule products secreted during the platelet release reaction.


Abnormal myeloid leukocyte morphology

description: An abnormality of myeloid leukocytes.


Erythroid dysplasia

description: Dysplasia in the erythroid lineage, which presents with a variety of morphological changes in the bone marrow, including nuclear budding or irregular nuclear contour in erythroblasts.


Reduced erythrocyte arginase activity

description: Activity or concentration of arginase (EC 3.5.3.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle.


Abnormality of neutrophils

description: A neutrophil abnormality.


Abnormal platelet shape

description: A deviation from the normal discoid platelet shape.


Abnormal hemoglobin concentration

description: Any deviation from the normal concentration of hemoglobin in the blood.


Abnormal eosinophil morphology

description: An abnormal count or structure of eosinophils.


Increased red blood cell count

description: An abnormal elevation above the normal number of red blood cells per volume in the circulation.


Abnormal hemoglobin

description: Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.


Hepatic hemophagocytosis

description: Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the liver.


Reduced bone-marrow pro-B cell count

description: A reduction in the numbers of pro-B cells (defined by coexpression of CD34 and CD19). Earlier B-cell precursors are defined by expressing surface CD34 and cytoplasmic TdT in the absence of CD19.


Fava bean-induced hemolytic anemia

description: A kind of hemolytic anemia that is induced by the ingestion of fava beans.


Megakaryocyte nucleus hyperlobulation

description: The presence of megakaryocytes in the bone marrow whose nuclei are more lobulated than expected for the size of the nucleus.


severe congenital neutropenia

description: A congenital disorder characterized by chronic neutropenia with absolute neutrophil count less than 500/uL and arrest of neutrophil maturation at the promyelocyte/myelocyte level. It is inherited in autosomal recessive or autosomal dominant patterns. Sporadic cases have also been reported. It is usually diagnosed in the first year of life. Patients present with frequent and life-threatening infections.


Howell-Jolly bodies

description: Howell-Jolly bodies are small, intra-erythrocytic remnants of erythrocyte nuclei. These inclusions are solitary in each erythrocyte and strongly basophilic. These are often confused with overlying platelets, but can be distinguished by the presence of a halo around overlying platelets.


Hypersegmentation of neutrophil nuclei

description: An excessive division of the lobes of the nucleus of a neutrophil.


Abnormal platelet morphology

description: An anomaly in platelet form, ultrastructure, or intracellular organelles.


name: Abnormal number of granulocyte precursors


Neutrophil inclusion bodies

description: The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neutrophils. Cytoplasmic neutrophil inclusions (oval, basophilic) are also known as Doehle bodies.


name: Decreased erythrocyte fructose-1,6-bisphosphate aldolase activity

description: Activity or concentration of fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) in red blood cells below the lower limit of normal.


Sickled erythrocytes

description: An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains).


Decreased red blood cell count

description: An abnormal reduction below the normal number of red blood cells per volume in the circulation.


name: Reduced erythrocyte gamma-glutamyl cysteine synthetase activity

description: Activity of gamma-glutamylcysteine synthetase (EC 6.3.2.2) in erythrocytes below the lower limit of normal.


Normocytic hypoplastic anemia

description: A type of hypoplastic anemia in which the erythrocytes have a normal cell volume (the mean corpuscular volume is within normal limits).


Abnormal red blood cell count

description: Any deviation from the normal number of red blood cells per volume in the circulation.


Monocytopenia

description: An decreased number of circulating monocytes.


name: Cyclic neutropenia in myeloid maturation arrest in bone marrow

description: Cyclic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow.


Reticulocytopenia

description: A reduced number of reticulocytes in the peripheral blood.


Bone marrow myeloid vacuolization

description: Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of myeloid precursors in the bone marrow.


Bone marrow xanthomatosis

description: Lipid deposits localized within the bone marrow. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.


name: Increased circulating immature neutrophil count

description: An abnormally increased number of immature neutrophils in the peripheral blood circulation.


Bone marrow hypercellularity

description: A larger than normal amount or percentage of hematopoietic cells relative to marrow fat.


Oval macrocytosis

description: Enlarged, oval-shaped erythrocytes (red blood cells).


heparin-induced thrombocytopenia

description: Heparin-induced thrombocytopenia (HIT) is a drug-induced, immune-mediated prothrombotic disorder associated with thrombocytopenia and venous and/or arterial thrombosis.


name: Increased erythrocyte UDP glucose-4-epimerase concentration

description: An increase in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.


Platelet anisocytosis

description: Abnormally increased variability in the size of platelets.


Abnormal monocyte morphology

description: Any structural anomaly of a myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.


name: Absence of Lutheran antigen on erythrocytes

description: Absence of the Lutheran antigen (a type I integral membrane glycoprotein) from the surface of red blood cells.


pyropoikilocytosis, hereditary

description: An autosomal recessive inherited severe hemolytic anemia. It is a subtype of hereditary elliptocytosis and is characterized by partial spectrin deficiency.


name: Impaired neutrophil bactericidal activity

description: A reduction in the ability of neutrophils to kill bacteria.


Target cells

description: Target cells (codocytes) have a centrally located disk of hemoglobin surrounded by an area of pallor with an outer rim of hemoglobin adjacent to the cell membrane giving the cell the appearance of a target.


Reduced alpha/beta synthesis ratio

description: A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia.


Hypoplastic anemia

description: Anemia with varying degrees of erythrocytic hypoplasia without leukopenia or thrombocytopenia.


Myeloid maturation arrest

description: Chornic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow.


Anemic pallor

description: A type of pallor that is secondary to the presence of anemia.


Hypereosinophilia

description: A severely increased count of eosinophils in the blood defined as a blood eosinophil count of at least 1.5 billion cells per liter.


Increased neutrophil mitochondria

description: An increased number of mitochondria detected in neutrophils.


familial hemolytic anemia

description: A congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies.


name: Abnormal erythrocyte metabolite concentration

description: A deviation from the normal range of a metabolite in red blood cells.


Bone marrow eosinophilia

description: Count of eosinophils in the bone marrow above the upper limit of normal.


Increased basophil count

description: An abnormally increased count of basophils per volume in the blood circulation.


name: Reduced erythrocyte inosine triphosphatase activity

description: Activity or concentration of inosine triphosphate pyrophosphohydrolase (EC 3.6.1.19) in red blood cells below the lower limit of normal.


Schistocytosis

description: The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood.


name: Increased mean corpuscular hemoglobin concentration

description: An elevation over the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell).


Hemoglobin Barts

description: Normal adult hemoglobin is composed of two chains each of alpha and beta globin. Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues.


HbC hemoglobin

description: Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a lysine (6GAG>6AAG). The presence of HbC can be determined by hemoglobin electrophoresis.


name: Increased circulating metamyelocyte count

description: The number of metamyelocytes in the peripheral blood circulation is above the upper limit of normal. Metamyelocytes are immature neutrophils with a size of 10-18 micrometers, an indented or kidney-shaped nucleus, pinkish-blue staining cytoplasm with secondary granules, and a nucleus:cytoplasm ratio of 1.5:1.


Lymph-node hemophagocytosis

description: Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages in a lymph node.


name: Abnormal morphology of erythroid progenitor cell

description: Abnormal form of the progenitor cells committed to the erythroid lineage.


Reduced red cell pyruvate kinase level

description: Decrease in the level of pyruvate kinase (PK) within erythrocytes. PK catalyzes the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.


Increased mean platelet volume

description: Average platelet volume above the upper limit of the normal reference interval.


Reduced bone-marrow megakaryocyte size

description: Decreased in average size (diameter) of megakaryocytes in the bone marrow. Megakaryocyte diameter can be assessed as using automated cellular imaging systems.


Increased mean corpuscular volume

description: Larger than normal size of erythrocytes.


Agranulocytosis

description: Marked decrease in the number of granulocytes.


description: A type of sideroblastic anemia that is alleviated by pyridoxine (vitamin B-6) treatment.


Abnormal platelet volume

description: Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers.


name: Reduced red cell adenosine deaminase level

description: Decrease in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.


Sterile pyuria

description: Patients who routinely have greater than 20 leukocytes per microliter, but have abacterial urine, are said to have sterile pyuria.


name: Abnormal erythroid lineage cell morphology

description: An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes.


Megakaryocytopenia

description: A reduced count of megakaryocytes.


name: Reduced erythrocyte adenylate kinase activity

description: Activity or concentration of in the level of adenylate kinase (EC 2.7.4.3) in erythrocytes below the lower limit of normal. Adenylate kinase is a ubiquitous monomeric enzyme that catalyzes the reversible conversion of MgATP plus AMP to MgADP plus ADP and contributes to homeostasis of the adenine nucleotide composition in the cell.


Abnormal reticulocyte morphology

description: A reticulocyte abnormality.


Absence of alpha granules

description: A lack of platelet alpha granules. This typically results in the gray appearance of platelets in giemsa stained blood smears.


CSF hemophagocytosis

description: Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the cerebrospinal fluid (CSF).


Increased bone marrow iron

description: An increased amount of iron in the bone marrow.


Dacryocytosis

description: Presence of teardrop-shaped red blood cells.


Reduced hemoglobin A

description: Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia.


name: Increased multinucleated megakaryocyte count

description: The presence of abnormally high numbers of multinucleated megakaryocytes in the bone marrow.


Pappenheimer bodies

description: A type of erythrocyte inclusion characterized by basophilic stippling of erythrocytes, that is, by numerous very small coarse or fine blue granules within the cytoplasm with the additional stipulation that the stippled particles are due to iron granules (demonstrable by the Prussian blue stain).


Decreased mean platelet volume

description: Average platelet volume below the lower limit of the normal reference interval.


name: Reduced erythrocyte glutathione reductase activity

description: Activity of glutathione reductase (EC 1.6.4.2) in erythrocytes below the lower limit of normal.


name: Ras-related protein Rab-4A isoform 1 (mouse)

description: A Ras-related protein Rab-4A isoform 1 that is encoded in the genome of mouse.


Ras-related protein Rab-4A isoform 1

A Ras-related protein Rab-4A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P20338-1 or a 1:1 ortholog thereof.


name: Ras-related protein Rab-4A isoform 1 (rat)

description: A Ras-related protein Rab-4A isoform 1 that is encoded in the genome of rat.


name: Ras-related protein Rab-4A isoform 1 (human)

description: A Ras-related protein Rab-4A isoform 1 that is encoded in the genome of human.


name: SMAD7_MOUSE Mothers against decapentaplegic homolog 7 (sprot)

description: A smad7 that is encoded in the genome of mouse.


name: mothers against decapentaplegic homolog 7 isoform A monomethylated 1 (mouse)

description: A mothers against decapentaplegic homolog 7 isoform A (mouse) that has been monomethylated at the position equivalent to Lys-70. UniProtKB:O35253-1, Lys-70, MOD:00085.


name: mothers against decapentaplegic homolog 7 isoform B (mouse)

description: A smad7 isoform 3 that is encoded in the genome of mouse.


name: smad7 isoform 1 phosphorylated 1 (mouse)

description: A smad7 isoform 1 phosphorylated 1 in mouse. UniProtKB:O35253-1, Ser-249, MOD:00046.


name: mothers against decapentaplegic homolog 7 isoform A (mouse)

description: A smad7 isoform 1 that is encoded in the genome of mouse.


name: mothers against decapentaplegic homolog 7 isoform A unmethylated 1 (mouse)

description: A mothers against decapentaplegic homolog 7 isoform A (mouse) that lacks a monomethylated Lys at position 70. UniProtKB:O35253-1, Lys-70, PR:000026291.


name: ENT4_ARATH Equilibrative nucleotide transporter 4 (sprot)

description: A protein that is a translation product of the ENT4 gene in Arabidopsis thaliana.


name: killer cell immunoglobulin-like receptor 2DL4 isoform h5 (human)

description: A killer cell immunoglobulin-like receptor 2DL4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99706-5.


name: M860_ARATH Uncharacterized mitochondrial protein AtMg00860 (sprot)

description: A protein that is a translation product of the AtMg00860 gene in Arabidopsis thaliana.


name: E9QPQ1_MOUSE Roundabout guidance receptor 3 (trembl)

description: A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of mouse. This isoform has a shorter N-terminal sequence in comparison with ROBO3A isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats.


name: roundabout homolog 3 isoform ROBO3.1 (mouse)

description: A roundabout homolog 3 (mouse) that has a C-terminal sequence that includes the region encoded by exons 26, 27 and 28. The resulting 78 amino acid peptide is highly enriched in arginine/serine dipeptide repeats.


name: roundabout homolog 3 isoform ROBO3A.1 (mouse)

description: A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of mouse. This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats.


name: KHDC4_CHICK KH homology domain-containing protein 4 (sprot)

description: A KH homology domain-containing protein 4 that is encoded in the genome of chicken.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h10 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-10.


name: disintegrin and metalloproteinase domain-containing protein 15

description: A protein that is a translation product of the human ADAM15 gene or a 1:1 ortholog thereof.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h11 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-11.


name: ADA15_HUMAN Disintegrin and metalloproteinase domain-containing protein 15 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 15 that is encoded in the genome of human.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform m2 (mouse)

description: A disintegrin and metalloproteinase domain-containing protein 15 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88839-2.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h13 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-13.


name: ADA15_MOUSE Disintegrin and metalloproteinase domain-containing protein 15 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 15 that is encoded in the genome of mouse.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform m3 (mouse)

description: A disintegrin and metalloproteinase domain-containing protein 15 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88839-3.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h1 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-1.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform m1 (mouse)

description: A disintegrin and metalloproteinase domain-containing protein 15 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88839-1.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h2 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-2.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform m4 (mouse)

description: A disintegrin and metalloproteinase domain-containing protein 15 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88839-4.


name: disintegrin and metalloproteinase domain-containing protein 15 cysteinylated 2 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that has been cysteinylated on the residue at the position equivalent to Cys-733 of the amino acid sequence represented by UniProtKB:Q13444-1. Example: UniProtKB:Q13444-1, Cys-733, MOD:00765.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h4 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-4.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h3 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-3.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform r2 (rat)

description: A disintegrin and metalloproteinase domain-containing protein 15 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QYV0-2.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h5 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-5.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h6 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-6.


name: ADA15_RAT Disintegrin and metalloproteinase domain-containing protein 15 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 15 that is encoded in the genome of rat.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform r1 (rat)

description: A disintegrin and metalloproteinase domain-containing protein 15 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QYV0-1.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h8 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-8.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h12 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-12.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h9 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-9.


name: disintegrin and metalloproteinase domain-containing protein 15 cysteinylated 1 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that has been cysteinylated on the residue at the position equivalent to Cys-117 of the amino acid sequence represented by UniProtKB:Q13444-1. Example: UniProtKB:Q13444-1, Cys-117, MOD:00765.


name: disintegrin and metalloproteinase domain-containing protein 15 isoform h7 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13444-7.


name: disintegrin and metalloproteinase domain-containing protein 15 deaminated 1 (human)

description: A disintegrin and metalloproteinase domain-containing protein 15 (human) that has been deaminated on the residue at the position equivalent to Asn-237 of the amino acid sequence represented by UniProtKB:Q13444-1. Example: UniProtKB:Q13444-1, Asn-237, MOD:00684.


sodium green

A quaternary ammonium salt that is the tetrakis(N,N,N-trimethylmethammonium) salt of 5-({[4-(13-{4-[({3-carboxy-4-[(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)methyl]phenyl}carbonyl)amino]-2,5-bis(methyloxy)phenyl}-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl)-2-hydroxy-5-(methyloxy)phenyl]amino}carbonyl)-2-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid.


name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 (human)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 in human. UniProtKB:P54646, Thr-172, PR:000026291.


name: regulation of nuclear pre-mRNA domain-containing protein 1B isoform m2 (mouse)

description: A regulation of nuclear pre-mRNA domain-containing protein 1B (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9CSU0-2.


name: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform h2 (human)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15118-2.


name: CG077_HUMAN Uncharacterized protein encoded by LINC03043 (sprot)

description: A protein that is a translation product of the LINC03043 gene in human.


ammonium magnesium phosphate

An inorganic phosphate that is the ammonium magnesium salt of phosphoric acid.


name: 3-[[2-furanyl(oxo)methyl]amino]-1H-indole-2-carboxylic acid ethyl ester


(S)-imazapyr

A 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinic acid that has S configuration.


beta-klotho isoform m1 (mouse)

A beta-klotho (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99N32-1.


histone H2A type 2-B isoform 1 (mouse)

A histone H2A type 2-B isoform 1 that is encoded in the genome of mouse.


name: ATP-binding cassette sub-family G member 8 isoform m1 (mouse)

description: An ATP-binding cassette sub-family G member 8 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9DBM0-1.


name: ABCG8_MOUSE ATP-binding cassette sub-family G member 8 (sprot)

description: An ATP-binding cassette sub-family G member 8 that is encoded in the genome of mouse.


name: ATP-binding cassette sub-family G member 8 isoform m2 (mouse)

description: An ATP-binding cassette sub-family G member 8 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9DBM0-2.


name: zinc finger E-box-binding homeobox 2 phosphorylated 1 (human)

description: A zinc finger E-box-binding homeobox 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-705 of the amino acid sequence represented by UniProtKB:O60315-1. Example: UniProtKB:O60315-1, Ser-705, MOD:00046.


name: ZEB2_HUMAN Zinc finger E-box-binding homeobox 2 (sprot)

description: A zinc finger E-box-binding homeobox 2 that is encoded in the genome of human.


name: zinc finger E-box-binding homeobox 2 isoform h2 (human)

description: A zinc finger E-box-binding homeobox 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60315-2.


name: zinc finger E-box-binding homeobox 2 isoform h1 (human)

description: A zinc finger E-box-binding homeobox 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60315-1.


conjunctival vascular disorder

description: A disorder of the vasculature of the cornea.


CSCL1_MOUSE CSC1-like protein 1 (sprot)

A CSC1-like protein 1 that is encoded in the genome of mouse.


name: CF132_MOUSE Uncharacterized protein C6orf132 homolog (sprot)

description: An uncharacterized protein C6orf132 that is encoded in the genome of mouse.


name: uncharacterized protein C6orf132 homolog isoform m2 (mouse)

description: An uncharacterized protein C6orf132 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91Z58-2.


name: uncharacterized protein C6orf132 homolog isoform m1 (mouse)

description: An uncharacterized protein C6orf132 homolog (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91Z58-1.


name: DNA replication factor Cdt1 phosphorylated 1 (human)

description: A DNA replication factor Cdt1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-394 of the amino acid sequence represented by UniProtKB:Q9H211. UniProtKB:Q9H211, Ser-394, MOD:00046.


name: CDT1_HUMAN DNA replication factor Cdt1 (sprot)

description: A DNA replication factor Cdt1 that is encoded in the genome of human.


name: DNA replication factor Cdt1 isoform 1 acetylated 1 (human)

description: A DNA replication factor Cdt1 isoform 1 acetylated 1 in human. UniProtKB:Q9H211-1, Lys-24/Lys-49, MOD:00064.


name: DNA replication factor Cdt1 isoform 1 (human)

description: A DNA replication factor Cdt1 isoform 1 that is encoded in the genome of human.


name: S-adenosylhomocysteine hydrolase-like protein 1 phosphorylated 1 (human)

description: An S-adenosylhomocysteine hydrolase-like protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-103 of the amino acid sequence represented by UniProtKB:O43865-1. Example: UniProtKB:O43865-1, Ser-103, MOD:00046.


beta-onocerin

A triterpenoid that is ethane in which each carbon has been substituted by a (4aS,6S,8aS)-6-hydroxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl group.


Fatty casts

description: A type of acellular urinary casts that contain lipid droplets, oval fat bodies or cholesterol crystals, and are often associated with the free forms of these elements. Their identification may require the use of polarized light microscopy, under which fatty particles embedded into the cast matrix appear as Maltese crosses.


name: infiltrating bladder urothelial carcinoma sarcomatoid variant

description: An invasive transitional cell carcinoma of the bladder that exhibits spindle cell sarcomatoid features.


name: infiltrating bladder urothelial carcinoma

description: An invasive transitional cell carcinoma that arises from the urinary bladder urothelium.


name: lymphoma-like variant infiltrating bladder urothelial carcinoma


name: plasmacytoid variant infiltrating bladder urothelial carcinoma

description: Invasive bladder urothelial carcinoma characterized by the presence of malignant cells with plasmacytoid features.