anatomical structure

description: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.


name: HLA class I histocompatibility antigen, alpha chain E, signal peptide removed form (human)

description: An HLA class I histocompatibility antigen, alpha chain E (human) that has had the signal peptide removed. UniProtKB:P13747, 22-358.


name: phospholipid-transporting ATPase IK isoform h2 (human)

description: A phospholipid-transporting ATPase IK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60423-1.


name: AT8B3_HUMAN Phospholipid-transporting ATPase IK (sprot)

description: A phospholipid-transporting ATPase IK that is encoded in the genome of human.


name: phospholipid-transporting ATPase IK cysteinylated 1 (human)

description: A phospholipid-transporting ATPase IK (human) that has been cysteinylated on the residue at the position equivalent to Cys-265 of the amino acid sequence represented by UniProtKB:O60423-2. Example: UniProtKB:O60423-2, Cys-265, MOD:00765.


name: phospholipid-transporting ATPase IK isoform h3 (human)

description: A phospholipid-transporting ATPase IK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60423-3.


name: phospholipid-transporting ATPase IK isoform h1 (human)

description: A phospholipid-transporting ATPase IK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60423-2.


name: receptor tyrosine-protein kinase erbB-4 isoform JM-A CYT-1 (mouse)

description: A receptor tyrosine-protein kinase erbB-4 isoform 1 that is encoded in the genome of mouse.


name: MPPE1_CAEEL Metallophosphoesterase 1 homolog (sprot)

description: A metallophosphoesterase 1 that is encoded in the genome of worm.


name: metallophosphoesterase 1 homolog isoform a (worm)

description: A metallophosphoesterase 1 homolog (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95X35-2.


name: metallophosphoesterase 1 homolog isoform b (worm)

description: A metallophosphoesterase 1 homolog (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q95X35-1.


A monomethoxybenzene that is 6-methoxyphenol substituted by a (all-trans)-hexaprenyl group at position 2.


Any member of the class of phenols that is phenol in which the hydrogens at positions 2 and 6 are substituted by a methoxy and an all-trans-polyprenyl group, respectively.


A 2-methoxy-6-(all-trans-polyprenyl)phenol in which the polyprenyl component is specified as all-trans-nonaprenyl.


A 2-methoxy-6-(all-trans-polyprenyl)phenol in which the polyprenyl component is specified as all-trans-heptaprenyl.


A 2-methoxy-6-(all-trans-polyprenyl)phenol in which the substituent at position 6 is an all-trans-octaprenyl moiety.


name: Cutaneous Melanoma pT3b TNM Finding v6 and v7

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Cutaneous melanoma 2.01 to 4 mm thick, with ulceration. (from AJCC 6th and 7th Eds.)


name: Cutaneous Melanoma Pathologic Primary Tumor TNM Finding v6

description: A pathologic finding about one or more characteristics of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


name: Cutaneous Melanoma pT2b TNM Finding v6 and v7

description: Cutaneous melanoma 1.01 to 2 mm thick, with ulceration. (from AJCC 6th and 7th Eds.)


name: Cutaneous Melanoma pT0 TNM Finding v6 and v7

description: Cutaneous melanoma with no evidence of primary tumor. (from AJCC 6th and 7th Eds.)


name: Cutaneous Melanoma pT2a TNM Finding v6 and v7

description: Cutaneous melanoma 1.01 to 2 mm in thickness, with no ulceration. (from AJCC 6th and 7th Eds.)


name: Cutaneous Melanoma pTis TNM Finding v6 and v7

description: Cutaneous melanoma in situ. (from AJCC 6th and 7th Eds.)


Cutaneous Melanoma pT1b TNM Finding v6

description: Cutaneous melanoma 1.0mm or less in thickness, with ulceration and/or Clark level IV or V. (from AJCC 6th Ed.)


name: Cutaneous Melanoma pT4a TNM Finding v6 and v7

description: Cutaneous melanoma greater than 4.0 mm in thickness, without ulceration. (from AJCC 6th and 7th Eds.)


name: Cutaneous Melanoma pT2 TNM Finding v6 and v7

description: Cutaneous melanoma 1.01 to 2 mm in thickness, with or without ulceration. (from AJCC 6th and 7th Eds.)


Cutaneous Melanoma pT1 TNM Finding v6

description: Cutaneous melanoma 1.0mm or less in thickness, with or without ulceration. (from AJCC 6th Ed.)


name: Cutaneous Melanoma pT4 TNM Finding v6 and v7

description: Cutaneous melanoma greater than 4.0 mm in thickness, with or without ulceration. (from AJCC 6th and 7th Eds.)


Cutaneous Melanoma pTX TNM Finding v6

description: Cutaneous melanoma in which the primary tumor cannot be assessed. (from AJCC 6th Ed.)


name: Cutaneous Melanoma pT3 TNM Finding v6 and v7

description: Cutaneous melanoma 2.01 to 4 mm thick, with or without ulceration. (from AJCC 6th and 7th Eds.)


name: Cutaneous Melanoma pT3a TNM Finding v6 and v7

description: Cutaneous melanoma 2.01 to 4 mm in thickness, with no ulceration. (from AJCC 6th and 7th Eds.)


Cutaneous Melanoma pT1a TNM Finding v6

description: Cutaneous melanoma 1.0mm or less in thickness and Clark level II or III, with no ulceration. (from AJCC 6th Ed.)


name: Cutaneous Melanoma pT4b TNM Finding v6 and v7

description: Cutaneous melanoma greater than 4.0 mm in thickness, with ulceration. (from AJCC 6th and 7th Eds.)


name: PDE1A_MOUSE Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of mouse.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

description: A protein that is a translation product of the human PDE1A gene or a 1:1 ortholog thereof.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform m2 (mouse)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61481-5.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h6 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-6.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform m4 (mouse)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61481-2.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h3 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-3.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform m3 (mouse)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61481-6.


name: PDE1A_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of human.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h2 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-2.


name: uncharacterized protein, PDE1A translation product (chicken)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of chicken.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, initiator methionine removed form (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that has had the initiator methionine removed. UniProtKB:P54750, 2-535.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h7 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-7.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h5 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-5.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h1 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-1.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h8 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-8.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h9 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-9.


name: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform h4 (human)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P54750-4.


psoriasis 13, susceptibility to

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Any psoriasis in which the cause of the disease is a mutation in the TRAF3IP2 gene.


name: ATP18_YEAST ATP synthase subunit J, mitochondrial (sprot)

description: A protein that is a translation product of the ATP18 gene in yeast.


cystatin-11 isoform 1

A cystatin-11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9D269-1 or a 1:1 ortholog thereof.


cystatin-11 isoform 1 (rat)

A cystatin-11 isoform 1 that is encoded in the genome of rat.


cystatin-11 isoform 1 (mouse)

A cystatin-11 isoform 1 that is encoded in the genome of mouse.


DB136_HUMAN Defensin beta 136 (sprot)

A defensin beta 136 that is encoded in the genome of human.


Grade 3 Colon Adenocarcinoma

description: A colon adenocarcinoma characterized by the presence of a malignant cellular infiltrate with less than 50% glandular formation.


A sulfonamide resulting from the formal condensation of the sulfonic acid group of mesitylene-2-sulphonic acid with the amino group of 2-(m-bromophenyl)ethylamine in which the nitrogen is substituted by a 4-[m-(methylsulfonyl)phenyl]benzyl group.


name: YIPF5_DICDI Protein YIPF5 homolog (sprot)

description: A protein YIPF5 that is encoded in the genome of Dictyostelium discoideum.


name: Grade 3 Cytokine Release Syndrome, CTCAE

description: Hypotension managed with one pressor; hypoxia requiring >= 40% O2


alpha-CYANO-4-HYDROXYCINNAMIC ACID

A monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides.


sialin sequence variant H183R (human)

A sialin (human) that has an Arg residue at the position equivalent to His-183 of the amino acid sequence represented by UniProtKB:Q9NRA2-1. Example: UniProtKB:Q9NRA2-1, His-183, CHEBI:29952.


name: immediate early response gene 5 protein cysteinylated 1 (human)

description: An immediate early response gene 5 protein (human) that has been cysteinylated on the residue at the position equivalent to Cys-52 of the amino acid sequence represented by UniProtKB:Q5VY09. UniProtKB:Q5VY09, Cys-52, MOD:00765.


pr protein

A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor form prM protein on the surface of immature dengue virus by host protease during virion maturation.


dengue virus genome polyprotein

A protein that is a translation product of the dengue virus serotype 2 genomic RNA or a 1:1 ortholog thereof.


name: dengue virus genome polyprotein proteolytic cleavage product

description: A dengue virus genome polyprotein, N-glycosylated form that has been processed by proteolytic cleavage.


NS1, with complex sugar attached

An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar.


POLG_DEN4S Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Singapore/8976/1995.


POLG_DEN26 Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/16681/84.


POLG_DEN4D Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Dominica/814669/1981.


POLG_DEN28 Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/0168/1979.


POLG_DEN2J Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Jamaica/1409/1983.


precursor of NS4B

A dengue virus genome polyprotein proteolytic cleavage product that is a precursor of NS4B.


prM (Dengue virus 2 Thailand/16681/84)

A prM in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 115-280, Asn-183, MOD:00160.


A dengue virus genome polyprotein proteolytic cleavage product that is a large non-structural protein encoded by the dengue virus RNA genome containing a methyltransferase (MTase) domain and an RNA dependent RNA polymerase (POL) domain that possesses a capping enzyme.


A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160.


POLG_DEN2P Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Puerto Rico/PR159-S1/1969.


2K (Dengue virus 2 Thailand/NGS-C/1944)

A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243.


A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5.


A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural, multifunctional protein encoded by the dengue virus RNA genome with a serine protease domain.


name: prM (Dengue virus 2 Thailand/NGS-C/1944)

description: A prM in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 115-280, Asn-183, MOD:00160.


NS4A (Dengue virus 2 Thailand/16681/84)

An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220.


name: NS5 (Dengue virus 2 Thailand/NGS-C/1944)

description: An NS5 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2492-3391.


A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic transmembrane non-structural protein encoded by the dengue virus RNA genome which is, in part, responsible for the membrane arrangements leading to the formation of the viral replication complex.


POLG_DEN1W Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Nauru/West Pac/1974.


A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein.


POLG_DEN3P Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Philippines/H87/1956.


name: NS1 (Dengue virus 2 Thailand/NGS-C/1944)

description: An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160.


A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome and a component of the viral replication complex.


C-prM

A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, glycosylated form and that consists only of the C (capsid) protein and the prM (pre-membrane) structural proteins of the dengue virus genome polyprotein. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 1-280, Asn-183, MOD:00160.


NS4B (Dengue virus 2 Thailand/16681/84)

An NS4B in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2244-2491.


A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen.


name: NS4A (Dengue virus 2 Thailand/NGS-C/1944)

description: An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220.


NS2B-NS3 polyprotein precursor

A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3.


POLG_DEN1B Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Brazil/97-11/1997.


POLG_DEN3C Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 China/80-2/1980.


name: NS4B (Dengue virus 2 Thailand/NGS-C/1944)

description: An NS4B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2244-2491.


POLG_DEN27 Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 16681-PDK53.


capsid protein C

A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein processed at the N-terminal end of the dengue virus RNA genome.


A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, N-glycosylated form and that contains the entire non-structural region of the dengue virus genome polyprotein only and is responsible for directing viral genomic RNA replication, including synthesizing negative- and positive-strand RNAs and forming the viral RNA cap structure. It consists of NS1, NS2A, NS3, NS4A, 2K, NS4B, and NS5.


name: NS2A (Dengue virus 2 Thailand/NGS-C/1944)

description: An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345.


A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome containing a conserved hydrophilic domain necessary for protease activity in cleavage of the dengue virus genome polyprotein, N-glycosylated form.


prM

A dengue virus genome polyprotein proteolytic cleavage product that is a product of the cleavage of C-prM by host signalase. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 115-280, Asn-183, MOD:00160.


POLG_DEN2Q Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Peru/IQT2913/1996.


name: M protein (Dengue virus 2 Thailand/16681/84)

description: An M protein in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 206-280.


M protein

A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor prM and localizes to the endoplasmic reticulum and forms oligomers.


POLG_DEN2N Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/NGS-C/1944.


POLG_DEN3I Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Singapore/8120/1995.


name: NS2B (Dengue virus 2 Thailand/NGS-C/1944)

description: An NS2B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1346-1475.


A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B.


A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5.


name: dengue virus genome polyprotein, N-glycosylated form

description: A dengue virus genome polyprotein that has been post-translationally modified to include N-glycosylated residues at Asn-183, Asn-347, Asn-433, Asn-905, and Asn-982. Example: UniProtKB:P29990, 1-3391, Asn-183/Asn-347/Asn-433/Asn-905/Asn-982, MOD:00160.


NS2A (Dengue virus 2 Thailand/16681/84)

An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345.


POLG_DEN4H Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Thailand/0476/1997.


precursor of NS5

A dengue virus genome polyprotein proteolytic cleavage product that is a precursor of NS5.


POLG_DEN3M Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Martinique/1243/1999.


E protein

A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein containing two alpha-helices (EH1 and EH2) at the C-terminus and two transmembrane domains (ET1 and ET2) of the dengue virus RNA genome. It contains two N-linked glycosylation sites, at Asn-67 and Asn-153. Example: UniProtKB:P29990, 281-775, Asn-347/Asn-433, MOD:00160.


A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B.


POLG_DEN1S Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Singapore/S275/1990.


name: NS3 (Dengue virus 2 Thailand/NGS-C/1944)

description: An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093.


POLG_DEN4T Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Thailand/0348/1991.


POLG_DEN4P Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Philippines/H241/1956.


POLG_DEN3S Genome polyprotein (sprot)

A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Sri Lanka/1266/2000.


A dengue virus genome polyprotein proteolytic cleavage product that consists of 188 amino acids at the N-terminal end of NS2A.


NS1, without complex sugar attached

An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar.


A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 consisting of NS1 and NS2A. It includes two N-glycosylated residues at Asn-130 and Asn-207. Example: UniProtKB:P29990, 776-1345, Asn-905/Asn-982, MOD:00160.


A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase.


name: T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form (human)

description: A T-cell surface glycoprotein CD8 alpha chain (human) that has had the signal peptide removed. UniProtKB:P01732, 22-235.


A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine in which the alkyl and the acyl groups at positions 1 and 2 are specified as methyl and hexadecanoyl respectively.


name: ANR61_HUMAN Ankyrin repeat domain-containing protein 61 (sprot)

description: An ankyrin repeat domain-containing protein 61 that is encoded in the genome of human.


name: BEN domain-containing protein 6 isoform h2 (human)

description: A BEN domain-containing protein 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5SZJ8-2.


name: Exocrine and Endocrine Pancreatic Cancer pTis TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with a finding of carcinoma in situ.  This also includes the PanIn III classification.  (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of exocrine or endocrine pancreatic cancer, following the rules of the TNM AJCC v7 classification system.


name: Exocrine and Endocrine Pancreatic Cancer pT0 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with no evidence of primary tumor. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer pT2 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with tumor limited to the pancreas, measuring more than 2 cm in greatest dimension. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer pNX TNM Finding v7

description: Exocrine or endocrine pancreatic cancer in which the regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer pN0 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with no regional lymph node metastasis. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer pTX TNM Finding v7

description: Exocrine or endocrine pancreatic cancer in which the primary tumor cannot be assessed. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer pT4 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with tumor involving the celiac axis or the superior mesenteric artery (unresectable primary tumor). (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of exocrine or endocrine pancreatic cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.


name: Exocrine and Endocrine Pancreatic Cancer pT1 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with tumor limited to the pancreas, measuring 2 cm or less in greatest dimension.. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer pM1 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with distant metastasis. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of exocrine or endocrine pancreatic cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for exocrine or endocrine pancreatic cancer. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer pN1 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with regional lymph node metastasis. (from AJCC 7th Ed.)


name: Exocrine and Endocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of exocrine or endocrine pancreatic cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Exocrine and Endocrine Pancreatic Cancer pT3 TNM Finding v7

description: Exocrine or endocrine pancreatic cancer with tumor extending beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery. (from AJCC 7th Ed.)


Src-like-adapter 2 isoform h4 (human)

A Src-like-adapter 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H6Q3-4.


Arg-Phe-Phe-Cys

A tetrapeptide composed of L-arginine, two L-phenylalanine units and L-cysteine joined in sequence by peptide linkages.


name: UBP51_HUMAN Ubiquitin carboxyl-terminal hydrolase 51 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 51 that is encoded in the genome of human.


name: ubiquitin carboxyl-terminal hydrolase 51 methylated 1 (human)

description: A ubiquitin carboxyl-terminal hydrolase 51 (human) that has been methylated on the residue at the position equivalent to Cys-593 of the amino acid sequence represented by UniProtKB:Q70EK9. UniProtKB:Q70EK9, Cys-593, MOD:00660.


name: zinc-alpha-2-glycoprotein N-glycosylated 22 (human)

description: A zinc-alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P25311-1, in which the glycan composition is represented by GlyTouCan:G03930BU. Example: UniProtKB:P25311-1, Asn-128, MOD:00160~GNO:G03930BU.


disorder of glutamate decarboxylase

description: A disease that has its basis in the disruption of glutamate decarboxylase activity.


A sphingomyelin d18:1 in which the ceramide N-acyl group is specified as lignoceroyl (tetracosanoyl).


name: zinc finger SWIM domain-containing protein 8 homolog isoform B (fruit fly)

description: A zinc finger SWIM domain-containing protein 8 homolog (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9VWN9-2.


name: proline-rich protein 5-like isoform 1 (rat)

description: A protor-2 isoform 1 that is encoded in the genome of rat.


A 1,2-diacyl-sn-glycerol in which both acyl groups are specified as hexanoyl.


name: MX2_RAT Interferon-induced GTP-binding protein Mx2 (sprot)

description: An interferon-induced GTP-binding protein Mx1 that is encoded in the genome of rat.


name: YHB8_CAEEL Uncharacterized protein ZC412.3 (sprot)

description: A protein that is a translation product of the ZC412.3 gene in worm.


name: Grade 1 Hepatic Vein Intra-Operative Injury, CTCAE


name: tripartite motif-containing protein 3 isoform Beta (human)

description: A tripartite motif-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75382-2.


name: TRIM3_HUMAN Tripartite motif-containing protein 3 (sprot)

description: A tripartite motif-containing protein 3 that is encoded in the genome of human.


name: tripartite motif-containing protein 3 isoform Gamma (human)

description: A tripartite motif-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75382-3.


name: tripartite motif-containing protein 3 deaminated 1 (human)

description: A tripartite motif-containing protein 3 (human) that has been deaminated on the residue at the position equivalent to Gln-191 of the amino acid sequence represented by UniProtKB:O75382-1. Example: UniProtKB:O75382-1, Gln-191, MOD:00685.


name: tripartite motif-containing protein 3 isoform Alpha (human)

description: A tripartite motif-containing protein 3 isoform 1 that is encoded in the genome of human.


name: tripartite motif-containing protein 3, initiator methionine removed form (human)

description: A tripartite motif-containing protein 3 (human) that has had the initiator methionine removed. UniProtKB:O75382, 2-744.


name: tripartite motif-containing protein 3 isoform h4 (human)

description: A tripartite motif-containing protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75382-4.


name: protein shisa-2 homolog isoform 1 (mouse)

description: A protein shisa-2 isoform 1 that is encoded in the genome of mouse.


protein shisa-2 isoform 1

A protein shisa-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6UWI4-1 or a 1:1 ortholog thereof.


name: protein shisa-2 homolog isoform 1 (human)

description: A protein shisa-2 isoform 1 that is encoded in the genome of human.


Testicular Cancer cT0 TNM Finding v8

description: Testicular cancer with no evidence of primary tumor. (from AJCC 8th Ed.)


name: RLA1_SCHPO Large ribosomal subunit protein P1A (sprot)

description: A protein that is a translation product of the rpp101 gene in Schizosaccharomyces pombe 972h-.


AGO6_ARATH Protein argonaute 6 (sprot)

A protein that is a translation product of the AGO6 gene in Arabidopsis thaliana.


name: CBLC_RAT E3 ubiquitin-protein ligase CBL-C (sprot)

description: An E3 ubiquitin-protein ligase CBL-C that is encoded in the genome of rat.


name: disks large-associated protein 5 cysteinylated 2 (human)

description: A disks large-associated protein 5 (human) that has been cysteinylated on the residue at the position equivalent to Cys-129 of the amino acid sequence represented by UniProtKB:Q15398-2. Example: UniProtKB:Q15398-2, Cys-129, MOD:00765.


name: cell division cycle 7-related protein kinase isoform h1 (human)

description: A cell division cycle 7-related protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00311-1.


tendon sheath lipoma

description: A benign tumor, composed of mature adipocytes, that arises within the tendon sheath.


benign synovial neoplasm

description: A benign neoplasm arising from the synovial membrane. Examples include the diffuse giant cell tumor of tendon sheath and localized giant cell tumor of tendon sheath.


name: tenosynovial giant cell tumor, localized type

description: A well-circumscribed, lobulated tumor, completely or partially covered by a fibrous capsule. It usually arises in the fingers. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. The tumor is slow-growing, usually developing over several years. Clinical presentation includes painless edema of the affected site.


name: tenosynovial giant cell tumor, diffuse type

description: A locally aggressive, diffusely infiltrating tumor, arising in the tendon sheath. It is composed of synovial-like mononuclear cells, hemosiderin-laden macrophages, foam cells, and inflammatory cells. Multinucleated osteoclast-like giant cells are usually present, although in a minority of cases they may be absent or rare. It predominantly affects young adults. Symptoms include joint swelling, pain, and joint effusion.


A zwitterion resulting from the transfer of a proton from the carboxy group to the nitrogen of the imino tautomer of 7-chloro-alpha,beta-didehydrotryptophan.


name: Rho guanine nucleotide exchange factor 9 isoform m3 (mouse)

description: A Rho guanine nucleotide exchange factor 9 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3UTH8-3.


name: ARHG9_MOUSE Rho guanine nucleotide exchange factor 9 (sprot)

description: A Rho guanine nucleotide exchange factor 9 that is encoded in the genome of mouse.


name: Rho guanine nucleotide exchange factor 9 isoform m2 (mouse)

description: A Rho guanine nucleotide exchange factor 9 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3UTH8-2.


name: Rho guanine nucleotide exchange factor 9 isoform 4 (mouse)

description: A Rho guanine nucleotide exchange factor 9 isoform 1 that is encoded in the genome of mouse.


name: Rho guanine nucleotide exchange factor 9 isoform m1 (mouse)

description: A Rho guanine nucleotide exchange factor 9 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3UTH8-1.


intestinal hypomagnesemia 1

description: Primary hypomagnesemia with secondary hypocalcemia (PHSH) is a form of familial primary hypomagnesemia (FPH), characterized by severe hypomagnesemia and secondary hypocalcemia associated with neurological symptoms, including generalized seizures, tetany and muscle spasms. PHSH may be fatal or may result in chronic irreversible neurological complications.


name: migration and invasion-inhibitory protein phosphorylated 1 (human)

description: A migration and invasion-inhibitory protein (human) that has been phosphorylated on the residue at the position equivalent to Ser-113 of the amino acid sequence represented by UniProtKB:Q5JXC2-1. Example: UniProtKB:Q5JXC2-1, Ser-113, MOD:00046.


name: MIIP_HUMAN Migration and invasion-inhibitory protein (sprot)

description: An invasion-inhibitory protein 45 that is encoded in the genome of human.


name: migration and invasion-inhibitory protein isoform h1 (human)

description: A migration and invasion-inhibitory protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5JXC2-1.


name: migration and invasion-inhibitory protein isoform h2 (human)

description: A migration and invasion-inhibitory protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5JXC2-2.


name: signal transducer and activator of transcription 1 unphosphorylated 1 (mouse)

description: A signal transducer and activator of transcription 1 (mouse) that lacks phosphorylation at Tyr-701 within the conserved GYI sequence following the SH2 domain. UniProtKB:P42225, Tyr-701, PR:000026291.


An alkane that is octane substituted by an ethyl group at position 3 and by methyl groups at positions 2 and 7. It is a urinary sex pheromone found in male mice.


name: protein delta homolog 2 isoform m2 (mouse)

description: A protein delta homolog 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8K1E3-1.


name: actin, cytoplasmic 1 acetylated 1 (human)

description: An actin, cytoplasmic 1 (human) that is N-terminal Met acetylated. UniProtKB:P60709, Met-1, MOD:00058.


H3L4_ARATH Histone H3-like 4 (sprot)

A protein that is a translation product of the At5g12910 gene in Arabidopsis thaliana.


KHK_HUMAN Ketohexokinase (sprot)

A ketohexokinase that is encoded in the genome of human.


ketohexokinase methylated 1 (human)

A ketohexokinase (human) that has been methylated on the residue at the position equivalent to Cys-282 of the amino acid sequence represented by UniProtKB:P50053-1. Example: UniProtKB:P50053-1, Cys-282, MOD:00660.


ketohexokinase isoform A (human)

A ketohexokinase isoform A that is encoded in the genome of human.


ketohexokinase isoform C (human)

A ketohexokinase isoform C that is encoded in the genome of human.


name: ketohexokinase sequence variant G40R (human)

description: A ketohexokinase (human) that has an Arg residue at the position equivalent to Gly-40 of the amino acid sequence represented by UniProtKB:P50053-1. Example: UniProtKB:P50053-1, Gly-40, CHEBI:29952.


name: ketohexokinase sequence variant A43T (human)

description: A ketohexokinase (human) that has a Thr residue at the position equivalent to Ala-43 of the amino acid sequence represented by UniProtKB:P50053-1. Example: UniProtKB:P50053-1, Ala-43, CHEBI:30013.


name: FB28_ARATH Putative F-box protein At1g32020 (sprot)

description: A protein that is a translation product of the At1g32020 gene in Arabidopsis thaliana.


SKP2A_ARATH F-box protein SKP2A (sprot)

A protein that is a translation product of the SKP2A gene in Arabidopsis thaliana.


name: Chronic Post-Rheumatic Arthropathy, Unspecified Wrist

description: Evidence of chronic post-rheumatic arthropathy in an unspecified wrist.


name: FSCC_DICDI Frizzled/smoothened-like sans CRD protein C (sprot)

description: A protein that is a translation product of the fscC gene in Dictyostelium discoideum.


name: ER membrane protein complex subunit 3 isoform h2 (human)

description: An ER membrane protein complex subunit 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P0I2-2.


A member of the class of 1,2-benzoxazoles carrying 2,4-dihydroxy-4-chlorophenyl and (2-morpholin-4-ylethyl)amino substituents at positions 3 and 5 respectively.


name: GP151_RAT Probable G-protein coupled receptor 151 (sprot)

description: A G-protein coupled receptor 151 that is encoded in the genome of rat.


name: PPIL3_DICDI Peptidyl-prolyl cis-trans isomerase-like 3 (sprot)

description: A peptidyl-prolyl cis-trans isomerase-like 3 that is encoded in the genome of Dictyostelium discoideum.


(S)-bopindolol

A 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate that has S-configuration.


An alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc(PP-Dol) in which the anomeric centre has alpha-configuration.


TYB_CAEEL Thymosin beta (sprot)

A protein that is a translation product of the tth-1 gene in worm.


name: ALK-negative anaplastic large cell lymphoma of intrapelvic lymph nodes

description: Evidence of anaplastic large cell lymphoma that is ALK-Negative in the intrapelvic lymph nodes.


name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 cysteinylated 1 (human)

description: A SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-147 of the amino acid sequence represented by UniProtKB:Q12824-1. Example: UniProtKB:Q12824-1, Cys-147, MOD:00765.


name: DRC1_RAT Dynein regulatory complex protein 1 (sprot)

description: A coiled-coil domain-containing protein 164 that is encoded in the genome of rat.


name: protein lin-9 homolog deaminated 1 (human)

description: A protein lin-9 homolog (human) that has been deaminated on the residue at the position equivalent to Asn-459 of the amino acid sequence represented by UniProtKB:Q5TKA1-1. Example: UniProtKB:Q5TKA1-1, Asn-459, MOD:00684.


name: proteasome subunit beta type-6 methylated 1 (human)

description: A proteasome subunit beta type-6 (human) that has been methylated on the residue at the position equivalent to Cys-186 of the amino acid sequence represented by UniProtKB:P28072. UniProtKB:P28072, Cys-186, MOD:00660.


name: BRAF_CHICK Serine/threonine-protein kinase B-raf (sprot)

description: A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of chicken.


name: serine/threonine-protein kinase B-raf isoform Short (chicken)

description: A serine/threonine-protein kinase B-raf (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04982-2.


name: serine/threonine-protein kinase B-raf isoform Long (chicken)

description: A serine/threonine-protein kinase B-raf (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04982-1.


A homoisoflavonoid that is cremastranone in which the phenolic hydroxy of the 3-hydroxy-4-methoxybenzyl group has undergone formal esterification with N-Boc-L-phenylalanine and in which both of the remaining hydroxy groups have undergone O-methylation.


name: ornithine aminotransferase, mitochondrial isoform 1 (rat)

description: An ornithine aminotransferase, mitochondrial isoform 1 that is encoded in the genome of rat.


name: cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P47985-1 or a 1:1 ortholog thereof.


name: cytochrome b-c1 complex subunit Rieske, mitochondrial

description: A protein that is a translation product of the human UQCRFS1 gene or a 1:1 ortholog thereof.


name: cytochrome b-c1 complex subunit Rieske, mitochondrial, transit peptide removed form

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that has had the transit peptide removed.


name: cytochrome b-c1 complex subunit Rieske, mitochondrial, transit peptide removed form (human)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P47985, 79-274.


name: cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 (mouse)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 that is encoded in the genome of mouse.


name: Q9VQ29_DROME Cytochrome b-c1 complex subunit Rieske, mitochondrial (trembl)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of fruit fly.


name: cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 (human)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 that is encoded in the genome of human.


name: cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 (rat)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial isoform 1 that is encoded in the genome of rat.


name: UCRI_HUMAN Cytochrome b-c1 complex subunit Rieske, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of human.


name: UCRI_CHICK Cytochrome b-c1 complex subunit Rieske, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of chicken.


name: cytochrome b-c1 complex Rieske-derived subunit 9

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that corresponds to the N-terminal portion after proteolytic cleavage by matrix processing peptidase. Example: UniProtKB:P47985, 1-78.


name: UCRI_SCHPO Cytochrome b-c1 complex subunit Rieske, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of Schizosaccharomyces pombe 972h-.


name: cytochrome b-c1 complex Rieske-derived subunit 9 (human)

description: A cytochrome b-c1 complex Rieske-derived subunit 9 in human. UniProtKB:P47985, 1-78.


name: UCRI_RAT Cytochrome b-c1 complex subunit Rieske, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of rat.


name: UCRI_MOUSE Cytochrome b-c1 complex subunit Rieske, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of mouse.


name: UCRI1_ARATH Cytochrome b-c1 complex subunit Rieske-1, mitochondrial (sprot)

description: A cytochrome b-c1 complex subunit Rieske, mitochondrial that is encoded in the genome of Arabidopsis thaliana.


name: intercellular adhesion molecule 2 N-glycosylated 1 (human)

description: An intercellular adhesion molecule 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P13598-1, in which the glycan composition is represented by GlyTouCan:G37399XV. Example: UniProtKB:P13598-1, Asn-176, MOD:00160~GNO:G37399XV.


name: heparin cofactor 2 N-glycosylated 8 (human)

description: A heparin cofactor 2 (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P05546-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P05546-1, Asn-49, MOD:00160~GNO:G94917XT.


name: Q5RK33_RAT Zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1 (trembl)

description: A U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 that is encoded in the genome of rat.


A dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a [2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino substituent.  It is an inhibitor of the BMK1 kinase pathway.


BURRODIN

A pseudoguaianolide that is decahydroazuleno[6,5-b]furan-2(3H)-one substituted by a hydroxy group a position 7, an oxo group at position 5, methyl groups at positions 4a and 8 and a methylidene group at position 3. It has been isolated from the aerial parts of Inula hupehensis.


lissamine flavine FF free acid

A member of the class of benzoisoquinolines that is 1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-5-sulfonic acid substituted by 4-tolyl and amino groups at positions 2 and 6 respectively. The monosodium salt is the biological stain 'lissamine flavine FF'.


rutarin

A monosaccharide derivative that is beta-D-glucopyranose in which the hydroxy group at position 1 is substituted by a [(2S)-2-(2-hydroxypropan-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-9-yl]oxy group. It is a natural product found in several plant species including Ruta graveolens and Citropsis articulata.


ERGOLIDE

A sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetyloxy group at position 4. It has been isolated from the aerial parts of Inula hupehensis.


METHYLBREVIFOLIN CARBOXYLATE

An organic heterotricyclic compound that is 1,2,3,5-tetrahydrocyclopenta[c]isochromene substituted by hydroxy groups at positions 7, 8 and 9, oxo groups at positions 3 and 5 and a methoxycarbonyl group at position 1. Isolated from  Phyllanthus urinaria and Phyllanthus niruri, it exhibits vasorelaxant activity.


A benzofuropyrimidine that is 3,4-dihydro[1]benzofuro[3,2-d]pyrimidine substituted by (2S)-pyrrolidin-2-yl, oxo and chloro groups at positions 2, 4, and 8, respectively. It is a potent ATP competitive inhibitor of Cdc7 kinase (IC50 = 3.4 nM) and exhibits anticancer properties.


CHAETOVIRIDIN A

An  azaphilone  that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a 3-hydroxy-2-methylbutanoyl group at position 9, a methyl group at position 6a and a 3-methylpent-1-en-1yl group at position 3. Isolated from Chaetomium globosum, it exhibits natifungal activity against plant pathogenic fungi.


A member of the class of pyrimidobenzodiazepines that is 5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a 4-[(4-methylpiperazin-1-yl)piperidine-1-carbonyl]-2-methoxyanilino substituent. It is an inhibitor of the Parkinson's disease kinase LRRK2.


AURASPERONE A

A dimeric naphthopyran with formula C32H26O10, originally isolated from Aspergillus niger.


A member of the class of aplysiatoxins that has the structure of the parent aplysiatoxin, but is carrying an additional bromo substituent on the benzene ring at the position ortho to the phenolic hydroxy group. It is a cyanotoxin produced by several species of freshwater and marine cyanobacteria, as well as algae and molluscs.


zuclopenthixol

The (Z)-isomer of clopenthixol.


imidazobenzazepine

Any organic heterotricyclic compound that consists of an imidazole ring ortho-fused to a benzazepine.


An iminium ion resulting from the protonation of the two imine groups of 11-beta-hydroxysaxitoxin; major microspecies at pH 7.3.


A member of the class of phenazines that is (10aS)-10,10a-dihydrophenazine substituted at position 1 by a carboxy group


2'-deoxycytidine dimer

A nucleoside analogue obtained by formal cyclodimerisation of 2'-deoxycytidine.


jacozine N-oxide

A pyrrolizine alkaloid that is jacozine in which the tertiary amino function has been oxidised to the corresponding N-oxide.


desacetylpyramidaglain D

A flavagline with a cyclopenta[bc]benzopyran skeleton isolated from the leaves of Aglaia forbesii. It exhibits antitubercular and antiviral activity.


Mo(=O)(=S)-molybdopterin cofactor

A Mo-molybdopterin cofactor that is MoO2-molybdopterin cofactor in which one of the oxygen atoms attached to molybdenum is replaced by a sulfur atom.


papulacandin D

A papulacandin that is papulacandin A in which the 6-O-acylgalactosyl group is replaced by a hydrogen. It is a carbohydrate-containing antibiotic from the deuteromycetous fungus Papularia sphaerosperma which shows potent antifungal activity against Candida albicans.


pyridobenzimidazole

An organic heterotricyclic compound that is any benzimidazole ortho-fused to a pyridine ring.


CASEANIGRESCEN C

A diterpenoid of the clerodane group isolated from the leaves and flowers of Casearia nigrescens. It exhibits cytotoxicity against A2780 human ovarian cancer cell line.


CHLORPROMAZINE HYDROCHLORIDE

The hydrochloride salt of chlorpromazine.


A member of the class of cyclobutadipyrimidines that is 1,4a,4b,8,8a,8b-hexahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,4,7(3H)-trione carrying additional methyl and amino substituents at positions 4a and 5 respectively.


fonsecinone B

A dimeric naphthopyran with formula C32H28O11, originally isolated from Aspergillus niger.


5-deoxystrigol ABC-rings

An indenofuran that is (3aR,8bS)-3,3a,4,5,6,7,8,8b-octahydro-2H-indeno[1,2-b]furan substituted by oxo, hydroxymethylidene, methyl, and methyl groups at positions 2, 3, 8, and 8, respectively.


A guaiacyl lignin obtained by formal cyclocodensation between guaiacylglycerol and esculetin. It is found in Arabidopsis thaliana.


(-)-homalomenol C

An organic heterotricyclic compound and sesquiterpenoid that is 11-oxatricyclo[5.3.1.0(2,6)]undecane-1,8-diol which is substituted by methyl groups at positions 5 and 8, and by an isopropyl group at position 5. The absolute stereochemistry is not known; it is either 1R,2S,5R,6R,7R,8R (as shown), or the enantiomer.


callophycoic acid B

A dibenzooxepine diterpenoid that is hexahydrodibenzo[b,e]oxepine with an isolated double bond between positions 6 and 6a and is substituted by a bromo, a carboxy, a 3E-4,8-dimethylnona-3,7-dien-1-yl and a methyl group at positions 9, 2, 10 and 10 respectively (the 9S,10S,10aR stereoisomer). An isomer of callophycoic acid A, it is isolated from the Fijian red alga Callophycus serratus and exhibits antibacterial, antimalarial and anticancer activities.


name: 2-chloro-10-phenothiazinecarboxylic acid ethyl ester


FUMIQUINAZOLINE A

A fumiquinazoline that consists of imidazoindole and pyrazinoquinazoline units connected by a methylene group.


dichotomide V

A  beta-carboline alkaloid isolated from Stellaria dichotoma var. lanceolata.


A member of the class of dibenzofurans that is dibenzo[b,d]furan substituted by chloro groups at positions 2 and 8 and a hydroxy group at position 3.


PRENYLCANDIDUSIN A

A member of the class of  dibenzofurans that is candidusin A substituted by a prenyl group at position 3 of the phenyl ring substituent. It has been isolated from Aspergillus taichungensis.


A pyrimidinothiazolopyrimidine that is dihydrothiochrome diphosphate in which the hydrogen at position 9a has been replaced by a 2-hydroxyethyl group.


A member of the class of phenazines that is 1,4,5,5a,6,9-hexahydrophenazine substituted at positions 1 and 6 by carboxy groups (the 1R,5aS,6R-diastereomer).


hyalodendriol C

An organic heterotricyclic compound that is 6H-benzo[c]chromen-6-one substituted by a methyl group at position 1, chloro group at position 2, methoxy group at position 3, and by hydroxy groups at positions 7 and 9. It is a metabolite isolated from Hyalodendriella species.


PHENAZINE

An azaarene that is anthracene in which the carbon atoms at positions 9 and 10 are replaced by nitrogen atoms.


(Z)-tomaymycin

The (Z)-isomer of tomaymycin.


dibenzooxazepine

An organic heterotricyclic compound consisting of two benzene rings fused to a seven-membered ring containing one oxygen and one nitrogen atom.


name: (E,E)-6-carbonyl-7-hydroxy-2,4-octadienoic acid 6-strobilactone-B ester


COLUMBIANADIN

An alpha,beta-unsaturated carboxylic ester obtained by formal condensation of the carboxy group of angelic acid with the hydroxy group of 2-[(8S)-2-oxo-8,9-dihydro-2H-furo[2,3-h][1]benzopyran-8-yl]propan-2-ol.


organic heterotricyclic compound

An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.


name: 1-[(6-methoxy-2-furo[2,3-b]quinolinyl)-oxomethyl]-4-piperidinecarboxylic acid ethyl ester


A member of the class of phenothiazines that is 4aH-phenothiazine substituted by dimethylamino groups at positions 3 and 7.


chloromonilicin

An organic heterotricyclic compound that is 5-chloro-10-hydroxy-8-methyl-1H-oxepino[4,3-b]chromene-3,11-dione which is substituted at positions 1, 5, 8, and 10 by methoxycarbonyl, chlorine, methyl, and hydroxy groups, respectively (the 1S enantiomer). Found in Monilia fructicola and in the mycoherbicide Alternaria sonchi.


RUBROFUSARIN

A member of the class of benzochromenones that is benzo[g]chromen-4-one carrying two additional hydroxy substituents at positions 5 and 6 as well as methyl and methoxy substituents at positions 2 and 8 respectively. An orange polyketide pigment that is a common intermediate in many different fungal biosynthetic pathways.


CHAETOCHROMIN B

A biaryl that is 2,2',3,3'-tetrahydro-4H,4'H-9,9'-bibenzo[g]chromene-4,4'-dione substituted by hydroxy groups at positions 5, 5', 6, 6', 8 and 8' and methyl groups at positions 2, 2', 3 and 3' (the 2R,2'S,3R,3'R stereoisomer). It has been isolated from Chaetomium gracile.


A member of the class of aminoacridines that is acridin-9-amine substituted by [(furan-2-yl)methyl]amino and ethoxy groups at positions 3 and 7, respectively. It is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 muM).


An organic heterotricyclic compound that is a 5'''-epimer of silvestrol. Isolated from Aglaia silvestris, it exhibits antineoplastic activity.


N-butylharmine

A member of the class of beta-carbolines that is 9H-beta-carboline substituted by a butyl group at position 9, methoxy group at position 7 and a methyl group at position 1. It is semisynthetic derivative of harmine and has been shown to exhibit significant anti-HIV activity.


A sesquiterpene lactone obtained by formal condensation of the carboxy group of 4-hydroxyphenylacetic acid with the 8-hydroxy group of 11beta,13-dihydrolactucin. Found in chicory.


(3aR,4R,9bS)-golgicide A

A 6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline that has 3aR,4R,9bS configuration.


saxitoxin

An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.


ACULEATOL E

An oxaspiro compound that is 1,7-dioxadispiro[5.1.5.2]pentadec-9-en-11-one substituted by hydroxy groups at positions 4 and 13 and a tridecyl group at position 2 (the (2R,4R,6S,8R,13S stereoisomer). It is isolated from the leaves of Amomum aculeatum and exhibits toxicity against some cancer cell lines like human lung carcinoma, hormone-dependent lung carcinoma and human breast carcinoma.


cercosporamide

A member of the class of dibenzofurans that is a potent broad spectrum antifungal agent isolated from the fungus Cercosporidium henningsii.


An organic heterotricyclic compound that is 9H-imidazo[1,2-a]benzimidazole which is substituted at positions 2, 3, and 9 by phenyl, 2,3-dimethoxycinnamoyl, and methyl groups, respectively. It is a potent activator of osteoblast differentiation.


PHENAZINE-1-CARBOXYLIC ACID

An aromatic carboxylic acid that is phenazine substituted at C-1 with a carboxy group.


alangicine

An isoquinoline alkaloid that is 1',2'-didehydroemetan bearing two hydroxy substituents at positions 6' and 9 as well as three methoxy substituents at positions 7', 10 and 11.


A dibenzodioxonine isolated from the culture broth of Penicillium asperosporum that acts as an acyl-CoA:cholesterol acyltransferase inhibitor.


altenuene

A benzochromenone mycotoxin isolated from the fungus Allernaria tenuis.


MOLLICELLIN C

A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by hydroxy groups at positions 3 and 9, a methoxy group at position 8, methyl groups at positions 1 and 6, a 3-methylbut-2-enoyl group at position 7, an oxo group at position 11 and a formyl group at position 4. Isolated from Chaetomium brasiliense, it exhibits antimalarial and cytotoxic activities.


A benzochromenone that is 6H-dibenzo[b,d]pyran substituted by an oxo group at position 6.


TRICYCLAZOLE

A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union.


columbianetin

The angular furanocoumarin analogue of the linear furanocoumarin marmesin.


(R)-profenamine

The (R)-enantiomer of profenamine.


NIGRASIN H

A  furochromene that is 8,9-dihydro-4H-furo[2,3-h]chromen-4-one substituted by a 2,4-dihydroxyphenyl group at position 2, a hydroxy group at position 5, methyl groups at positions 8, 9 and 9 and a prenyl group at position 3. It has been isolated from the twigs of Morus nigra and has been found to promote adipogenesis.


FABESETRON

An organic heterotricyclic compound that is 8,9-dihydropyrido[1,2-a]indol-6(7H)-one substituted by a (5-methyl-1H-imidazol-4-yl)methyl group at position 7R and a methyl group at position 10. It is a dual 5-HT3 and 5-HT4 receptors antagonist whose clinical development was terminated in phase II. It was being developed for the treatment of chemotherapy-induced emesis and irritable bowel syndrome.


phenazines

Any  organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives.


A member of the class of beta-carbolines that is 9H-beta-carboline substituted by a methoxy group at position 7 and methyl groups at positions 1 and 2. It is a semisynthetic derivative of harmine and has been shown to exhibit significant anti-HIV activity.


lucanthone

A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.


MOLLICELLIN J

A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by a chloro group at position 2, hydroxy groups at position 3 and 7, methyl group at positions 1 and 9, a prenyl group at position 8, an oxo group at position 11 and a formyl group at position 4. Isolated from Chaetomium brasiliense it exhibits cytotoxic activity.


seneciphylline N-oxide

A pyrrolizine alkaloid that is produced by a hybrid species of Jacobaea.


grixazone A

A cysteine derivative that is the S-(2-amino-8-formyl-3-oxo-3H-phenoxazin-1-yl) derivative of N-acetyl-L-cysteine.


A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers.


leucascandrolide A congener

A synthetic macrolide that is an analogue of the marine metabolite leucascandrolide A that exhibits comparable antiproliferative properties.


synthetic strigolactone

Any strigolactone not biosynthesised from carotenoids.


A pseudoguaianolide with anti-inflammatory activity isolated from the aerial parts of Inula hupehensis.


A member of the class of phenazines that is 5,10-dihydrophenazine substituted at positions 1 and 6 by carboxy groups.


calcein red-orange

A BODIPY dye-based amide conjugate.


CASEANIGRESCEN A

A diterpenoid of the clerodane group isolated from the leaves and flowers of Casearia nigrescens. It exhibits cytotoxicity against A2780 human ovarian cancer cell line.


paralytic shellfish toxin

An alkaloid compound that is 2,6-diamino-4-methyl-pyrollo[1,2-c]-purin-10-diol produced by several cyanobacteria and dinoflagellates, which can result in paralytic shellfish poisoning when ingested.


emetamine

A pyridoisoquinoline consisting of emetine having a fully aromatised isoquinoline.


A 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one in which both stereocentres have R configuration.


beta-aminoorcein

A member of the class of phenoxazines that is 1,9-dimethyl-3H-phenoxazin-3-one carrying an additional amino substituent at position 7 as well as two 2,4-dihydroxy-6-methylphenyl substituents at positions 2 and 8. The isomer in which the hydroxy groups at positions 2' and 2'' on the phenyl rings are both on the same side of the plane of the phenoxazine ring system. A component of orcein, a mixture of dyes isolated from lichens.


An N-oxide that is 1,6-dimethoxyphenazine carrying oxido groups at positions 5 and 10; Major microspecies at pH 7.3.


A member of the class of psoralens that is xanthotoxin substituted by a hydroxy group at position 5.


dibenzothiophene 5-oxide

A member of the class of dibenzothiophenes that is the 5-oxo derivative of dibenzothiophene.


A guaiane sesquiterpenoid with anti-inflammatory activity isolated from the aerial parts of Inula hupehensis.


A benzoisoquinoline that is 1H-benzo[de]isoquinoline-1,3(2H)-dione in which the hydrogen attached to the nitrogen has been replaced by a 3-[(2-carboxyphenyl)thio]propyl group. It is a selective LPA2 receptor non-lipid agonist.


W-molybdopterin cofactor

A molybdopterin cofactor in which the coordinated metal is a mononuclear tungsten or tungstate species.


An azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis.


A nucleobase analogue obtained by addition of an etheno group across positions N2 and 3 of guanine.


name: DESACETYL (7)KHIVORINIC ACID, METHYL ESTER


CASEARGREWIIN D

A diterpenoid of the clerodane group isolated from the bark of Casearia grewiifolia and has been shown to exhibit antimalarial and antimycobacterial activity.


BODIPY TR-X phallacidin

A BODIPY dye conjugated to the bicyclic peptide phallacidin via an amide linkage.


hyperaspidinol A

An  organic heterotricyclic compound found in Hypericum chinense.


A diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1).


A member of the class of thianthrenes that is thianthrene substituted by a 4-oxo-6-(piperidin-1-yl)-4H-pyran-2-yl group at position 1. It is a weakly active inhibitor of ATM kinase.


alternariol hapten ALb

An alternariol hapten that is one of two regioisomeric haptens of the mycotoxin alternariol in which the five-atom carboxylated aliphatic spacer arm is located through the hydroxy group at C-3.


name: (3S)-2-(2-chloro-1-oxoethyl)-1,1-dimethyl-4,9-dihydro-3H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester


A benzylisoquinoline alkaloid that is 8-hydroxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline which is substituted at the 1-pro-R position by an (acetyloxy)(2-formyl-3,4-dimethoxyphenyl)methyl group. An intermediate in the biosynthesis of noscarpine in the opium poppy, Papaver somniferum.


pyranochromane

An organic heterotricyclic compound that consists of a pyran ring fused on to a chromane skeleton.


INUCHINENOLIDE B

A sesquiterpene lactone that is 3a,4,4a,5,6,7,9,9a-octahydroazuleno[6,5-b]furan-2(3H)-one substituted by a hydroxy group at position 5, methyl groups at positions 5 and 8, an acetyloxy group at position 7 and a methylidene group at position 3. It has been isolated from the aerial parts of Inula hupehensis.


pacatal

A phenothiazine derivative in which 10H-phenothiazine has an N-methylpiperidin-4-ylmethyl substituent at the N-10 position.


LISSOCLIBADIN 2

An organosulfur heterocyclic compound isolated from the ascidian Lissoclinum badium. It has been shown to exhibit cytotoxicity against human cancer cell lines.


BRUCEOLLINE I

An indole alkaloid that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by hydroxy groups at positions 2 and 6, geminal-methyl groups at position 3 and an oxo group at position 1. It has been isolated from the ethanol extract of the stems of Brucea mollis.


CHINOMETHIONAT

A dithioloquinoxaline that results from the formal condensation of 6-methylquinoxaline-2,3-dithiol with phosgene. It has been used as a fungicide and acaricide for the control of mites and powdery mildew on citrus, vegetables, and walnuts, but is not approved for use in the EU.


botrallin

An organic heterotricyclic compound that is 2,4a-dihydro-6H-benzo[c]chromen-6-one substituted by hydroxy groups at positions 1 and 7, an oxo group at position 2, methoxy groups at positions 3 and 9, and a methyl group at position 4a. It is isolated from Hyalodendriella species.


A flavin carrying a formyl group at C-10.


fendosal

A benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity.


name: 9H-pyrido[3,4-b]indole-3-carboxylic acid propyl ester


michigazone

A member of the class phenoxazines that is 3H-phenoxazine substituted by methoxy, oxo, methoxy and hydroxymethyl groups at positions 2, 3, 4 and 8, respectively. It is a red pigment produced by the soil bacterium Streptomyces michiganensis.


A triazinoindole that is 5H-[1,2,4]triazino[5,6-b]indole which is substituted at position 3 by a (2-methylprop-2-en-1-yl)thio group. A potent inhibitor of midasin which is an essential protein for eukaryotic ribosome biogenesis.


beta-carboline alkaloid

Any indole alkaloid based on a beta-carboline (9H-pyrido[3,4-b]indole) skeleton.


yadanziolide V

A  quassinoid  isolated from he ethanol extract of the stem of Brucea mollis.


OXYPEUCEDANIN

A furanocoumarin that is 7H-furo[3,2-g][1]benzopyran-7-one substituted by a [(2S)-3,3-dimethyloxiran-2-yl]methoxy group at position 4.


dehydrojaconine

A pyrrolizine alkaloid that is jacoline in which the secondary hydroxy group has been replaced by a chlorine and the 5-methyl group has been replaced by methylene.


orbiculin I

A dihydroagarofuran sesquiterpenoid that consists of dihydro-beta-agarofuran substituted by an acetoxy group at position 1 and furoyloxy groups at positions 2, 6 and 9 (the 1beta,2beta,6alpha,9alpha stereoisomer). Isolated from Celastrus orbiculatus, it exhibits inhibition of both NF-kappaB activation and nitric oxide production.


depsidone

The simplest member of the class of  depsidones comprising of a heterotricyclic system that is 11H-dibenzo[b,e][1,4]dioxepine substituted by an oxo group at position 11.


pannarin

A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by methyl groups at positions 1,6 and 9, chloro group at position 2, hydroxy group at position 3, formyl group at position 4, methoxy group at position 8 and an oxo group at position 11. It is a lichen metabolite isolated from several Psoroma species.


An organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1.


(-)-chimonanthine

The (3aS,3a'S,8aS,8a'S)-stereoisomer of chimonanthine.


lymphostin

A member of the class of pyrroloquinolines that is pyrrolo[4,3,2-de]quinoline in which the hydrogens at positions 4, 6 and 8 are replaced by (1E)-1-methoxy-3-oxoprop-1-en-3-yl, acetylamino and amino groups, respectively. It is an alkaloid isolated from Streptomyces and Salinispora species, exhibits potent immunosuppressive activity, and inhibits Fyn and Lck protein kinases.


BRUCEOLLINE H

An indole alkaloid that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by a hydroxy group at position 6, geminal-methyl groups at position 3 and oxo groups at positions 1 and 2. It has been isolated from the ethanol extract of the stems of Brucea mollis.


An imidazochromene that is 1,7,8,9-tetrahydrochromeno[5,6-d]imidazol-2-amine bearing additional 3-(dimethylamino)propyl and (dimethylamino)methyl substituents at positions 1 and 8 respectively (the R-enantiomer).


A member of the class of thienotriazolodiazepines that is the methyl ester of [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid.


phomacin A

A cytochalasin isolated from a fungus Phoma sp. that has been shown to possess potent inhibitory activity against HT-29 colonic adenocarcinoma cells.


5'-epichaetoviridin A

An  azaphilone that is the 5'-epimer of chaetoviridin A. It has been isolated from Chaetomium globosum.


PYROQUILON

A pyrroloquinoline that is 1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline in which the hydrogens at position 4 are replaced by an oxo group. A fungicide used to control rice blast, it is not approved wof use within the European Union.


A member of the class of rifamycins that is obtained by formal N-hydroxylation at position 2' of rifampicin.


aplysiatoxin

The parent member of the class of aplysiatoxins. It is a cyanotoxin produced by several species of freshwater and marine cyanobacteria, as well as algae and molluscs.


cleistanthin E

A member of the class of cleistanthins that is cleistanthin C in which the hydroxy group at position 4 of the 2,3-di-O-methyl-beta-D-xylopyranosyl moiety has been converted to the corresponding 2,3,5-tri-O-methyl-D-xylofuranoside.


FMN-L-threonine

A L-threonine derivative that is L-threonine attached via its side-chain to FMN via a phosphate linkage.


IMINOSTILBENE

A mancude organic heterotricyclic parent that consists of a seven-membered nitrogen hetrocycle fused with two benzene rings.


4-hydroxymidazolam beta-D-glucuronide

A beta-D-glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen has been replaced by a 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl group. It is the glucuronidated conjugate of the midazolam metabolite, 4-hydroxymidazolam.


KLUGINE

An isoquinoline alkaloid that is emetan substituted by methoxy groups at positions 7' and 11 and hydroxy groups at positions 1', 6' and 10'. Isolated from Psychotria klugii, it exhibits antileishmanial and antiplasmodial activities.


FUMIQUINAZOLINE F

A fumiquinazoline that consists of pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione bearing a methyl substituent at position 1 and an indol-3-yl group at position 4.


pentalenolactone D

A sesquiterpene lactone obtained by regioselective Bayer-Villiger oxidation of 1-deoxy-11-oxopentalenic acid.


acridine yellow cation

The monoprotonated form of 2,7-dimethylacridine-3,6-diamine.


acroptilin

A sesquiterpene lactone that is isolated from Acroptilon repens and displays anti-allergic properties.


dibenzodioxonine

An organic heterotricyclic compound that consists of a 9-membered dioxonine fused with 2 benzene rings.


ACIDIATHIAZONE A

An organic heterotricyclic compound,  that is 3,4-dihydro-2H-[1,4]thiazino[2,3-g]quinoline-5,10 dione S,S-dioxide substituted at position 7 by a carboxyl group. It is an anti-inflmmatory alkaloid obtained from Aplidium.


fonsecin B

A naphtho-gamma-pyrone that is fonsecin in which the hydroxy group at position 8 (meta to the methoxy group) has been converted to the corresponding methyl ether. Found in Aspergillus fonsecaeus.


An extended flavonoid that consists of (2S)-flavanone substituted by hydroxy groups at positions 5 and 4', a methoxy group at position 3' , a prenyl group at position 6 and a gem-dimethylpyran ring fused across positions 7 and 8. Isolated from Lonchocarpus utilis and Lonchocarpus urucu, it acts as a NADH:ubiquinone reductase inhibitor.


name: 5-hydroxy-2-methyl-4-[1-piperidinyl(3-pyridinyl)methyl]-3-benzo[g]benzofurancarboxylic acid ethyl ester


A flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1.


pyridoisoquinoline

An organic heterotricyclic compound with a skeleton derived from a pyridine ring fused to an isoquinoline.


laccaridione B

An organic heterotricyclic compound that is 1H-benzo[g]isochromene-8,9-dione substituted by an ethoxy group at position 1, hydroxy group at position 10, a methoxy group at position 7 and a 4-methylhex-2-en-2-yl group at position 3. Isolated from the stem of the fruiting bodies of the basidiomycete strain Laccaria amethystea, it exhibits inhibitory activity against proteases.


ATTO 465-2(1+)

The cationic form of 3,6-diamino-10-(3-carboxypropyl)acridine.


A dihydroagarofuran sesquiterpenoid that consists of dihydroagarofuran substituted by a acetyloxy group at position 1, benzyloxy groups at positions 6, 9 and 15 and a hydroxy group at position 2. It is isolated from the roots of Microtropis fokienensis and exhibits antitubercular activity.


pterolinus I

An organic heterotricyclic compound found in Pterocarpus santalinus.


papulacandin C

A papulacandin that is papulacandin A in which the (2E,4E)-deca-2,4-dienoyl chain at the O-(6') position is replaced by a (2E,4E,6E)-8-hydroxydeca-2,4,6-trienoyl chain. It is a carbohydrate-containing antibiotic from the deuteromycetous fungus Papularia sphaerosperma which shows potent antifungal activity against Candida albicans.


A flavin mononucleotide that is FMN in which the 8-methyl group has been oxidised to the corresponding carboxylic acid.


RUBROROTIORIN

An  azaphilone that is 6,6a-dihydro-8H-furo[2,3-h]isochromen-6,8(6aH)-dione substituted by an acetyl group at position 9, a chloro group a position 5, a 3,5-dimethylhepta-1,3-dien-1-yl group at position 3 and a methyl group at position 6a.  Isolated from Chaetomium cupreum, it exhibits antifungal activity.


(S)-aceprometazine

The (S)-enantiomer of aceprometazine.


lactucin

An azulenofuran that is 3-methylidene-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione carrying additional hydroxy, methyl and hydroxymethyl substituents at positions 4, 6 and 9 respectively (the 3aR,4S,9aS,9bR-diastereomer). Found in chicory.


FLAVALIN C

A sesquiterpenoid of the class of nardosinane-type terpenoids isolated from the Formosan soft coral Lemnalia flava.


rotiorinol B

An  azaphilone that is 9,9a-dihydro-2H-furo[3,2-g]isochromen-2-one substituted by an acetyl group at position 3, a hydroxy group at position 9 a 5-hydroxy-3,5-dimethylhepta-1,3-dien-1-yl group at position 6 and a methyl group at position 9a. It has been isolated from Chaetomium cupreum.


flavasperone

A naphtho-gamma-pyrone that is 4H-naphtho[1,2-b]pyran-4-one carrying a methyl substituent at position2, a hydroxy substituent at position 5 and two methoxy substotuents at positions 8 and 10. Originally isolated from Aspergillus niger.


An organic heterotricyclic compound arising from formal [4+2]-cycloaddition of hexachlorocyclopentadiene to N-methylmaleimide.


BRUCEOLLINE K

An indole alkaloid that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by geminal-methyl groups at position 3, an oxo group at position 1 and a beta-D-glucopyranosyloxy group at position 2.It has been isolated from the ethanol extract of the stems of Brucea mollis.


(3aS,4R,9bR)-golgicide A

A 6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline that has 3aS,4R,9bR configuration. It is the most active stereoisomer of golgicide A.


benzochromenone

A benzochromene in which the heterotricyclic ring system is substituted by an oxo group.


A pseudoguaianolide with anti-inflammatory activity isolated from the aerial parts of Inula hupehensis.


OCHROCARPIN B

A furanocoumarin that is 2H-furo[2,3-h]chromen-2-one substituted by a hydroxy group at position 5, 2-hydroxypropan-2-yl group at position 8, a 3-methylbutanoyl group at position 6 and a phenyl group at position 4. Isolated from the bark of Ochrocarpos punctatus, it exhibits cytotoxicity against the A2780 ovarian cancer cell line.


CHERMESINONE C

An  azaphilone that is 9a,9b-dihydro-1H-furo[2,3-h]isochromene-6,8(6aH,9H)-dione substituted by a hydroxy group at position 1, methyl groups at positions 3 and 6a and a 2-methylbutanoyl group at position 9. It has been isolated from the culture of the mangrove endophytic fungus Penicillium chermesinum.


GRAVEOLIDE

A sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8 and a methylidene group at position 3. It has been isolated from the aerial parts of Inula hupehensis.


LONGIROSTRERONEA

An  azaphilone that is 9,9a-dihydro-6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a 4-hydroxy-2-methyl-6-oxocyclohexyl group at position 3, a methyl group at position 6a and a 4,6,8-trimethyldeca-2,4-dienoyl group at position 9. Isolated from Chaetomium longirostre, it exhibits cytotoxic and antimalarial activities.


A furanocoumarin which bears a methoxy group at position 8.


An indenofuran in which the hydroxy group of the 5-deoxystrigol ABC-rings in substituted by a [(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy group.


DITHIANON

A naphthodithiin that is 5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithiin which is substituted by nitrile groups at positions 2 and 3. It is a broad spectrum fungicide used to control scab, downy mildew, rust, and leaf spot in the commercial growing of grapes and other fruit, citrus, coffee, and vegetables.


11beta,13-dihydrolactucin 15-glycoside

A terpene glycoside obtained by glycosylation of the 15-hydroxy group of 11beta,13-dihydrolactucin. Found in chicory.


name: (R)-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester

description: A diester obtained by formal condensation of the carboxy groups of glutaric acid with the hydroxy groups of (R)-1,2-di-O-dodecanylglycerol and 7-hydroxy-6-methylphenoxazin-3-one.


(S)-mosapramine

A 1'-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one that has (S)-configuration.


A sesquiterpene lactone obtained by formal hydrogenation across the 11,13-double bond of lactucin. Found in chicory


FUTOENONE

A  neolignan with formula C20H20O5 that is isolated from Magnolia sprengeri and Piper wallichii.


N-hydroxy-MeIQx

An imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by a hydroxyamino group. The active metabolite of the dietary carcinogen MeIQx.


A pyridoisoquinoline consisting of (1'beta)-emetan substituted by hydroxy groups at positions 6' and 7' and methoxy groups at positions 10 and 11. It is isolated from Psychotria klugii and exhibits antileishmanial activity.


A sesquiterpene lactone that is the C-8 epimer of inuviscolide. It has been isolated from the aerial parts of Inula hupehensis.


A sesquiterpene lactone obtained by formal condensation of one of the carboxy groups of oxalic acid with the 15-hydroxy group of 11beta,13-dihydro-8-deoxylactucin. Found in chicory.


acronycidine

A quinoline alkaloid that is furo[2,3-b]quinoline bearing four methoxy substituents at positions 4, 5, 7 and 8.


A naphthofuran obtained by selective hydrogenation of the 1,2-position of alpha-santonin.


PRENYLCANDIDUSIN C

A member of the class of dibenzofurans that is 3,6,9-trimethoxydibenzo[b,d]furan-2-ol substituted by a 4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl substituent at position 3. It has been isolated from Aspergillus taichungensis.


promazine sulfoxide

A member of the class of  phenothiazines that is promazine carrying an oxo group at position 5. It is a metabolite of the anti-psychotic medication, chlorpromazine.


UCS1025 A

An organic heterotricyclic compound that incorporates a lactam and a gamma-lactone as part of the cyclic system which in turn is attached to a (2,4a,8a-trimethyl-octahydronaphthalen-1-yl)carbonyl group at position 7. It is isolated from Acremonium sp. KY4917 and exhibits antibacterial activity.


name: Deschloro 12-epi-fischerindole W nitrile


name: 3-methyl-2-benzo[g]benzofurancarboxylic acid [2-[N-(2-cyanoethyl)anilino]-2-oxoethyl] ester


BODIPY compound

A compound that contains a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene skeleton.


name: 2-amino-9-ethyl-3-pyrido[2,3-b]indolecarboxylic acid ethyl ester


MOLLICELLINE K

A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by hydroxy groups at positions 3 and 7, methyl groups at positions 1 and 9, a 3-methylbut-2-enoyl group at position 8, a formyl group at position 4 and an oxo group at position 11. Isolated from Chaetomium brasiliense, it exhibits antimalarial, antimycobacterial and cytotoxic activities.


triazinoindole

Any heterotricyclic compound whose skeleton consists of an indole fused to a triazine ring.


BIGELOVIN

A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetoxy group at position 4. Isolated from Inula hupehensis, it exhibits antineoplastic activity.


FLAVALIN B

A sesquiterpenoid of the class of nardosinane-type terpenoids isolated from the Formosan soft coral Lemnalia flava, and has been shown to exhibit neuroprotective activity.


A member of the class of beta-carboline that is 9H-beta-carboline substituted by bromo, methoxy and a methyl group at positions 5, 8 and 1 respectively. It is isolated from a marine bryozoan Pterocella vesiculosa and has been found to exhibit moderate antitumour activity against the P388 murine leukemia cell line. Additionally it shows antimicrobial activity towards the Gram-positive bacterium Bacillus subtilis and the fungi Candida albicans and Trichophyton mentagrophytes.


triptofordin C 2

A dihydroagarofuran sesquiterpenoid that is isolated from Tripterygium wilfordii.


A beta-alanine derivative obtained by formal condensation of the carboxy group of (10-methyl-9,10-dihydroacridin-9-yl)carboxylic acid with the amino group of beta-alanine.


Dibenzothiophene substituted at positions 1 and 2 by hydroxy groups.


A member of the class of dibenzoazepines that is the amide formed from formal condensation of the carboxy group of 2,2-dimethyl-3-oxo-3-[(2,2,3,3,3-pentafluoropropyl)amino]propanoic acid with the amino group of (7S)-7-amino-5,7-dihydrodibenzo[b,d]azepin-6-one.


A fluoroindole that is 1H-indole in which the hydrogens at positions 3 and 6 are replaced by 1-[2-(2,2-dioxo-5,6-dihydro-4H-2lambda(6)-[1,2,5]thiadiazolo[4,3,2-ij]quinolin-1(2H)-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl and fluoro groups, respectively. It is an inhibitor of the 5-hydroxytryptamine transporter (Ki = 2.3 nM) and an antagonist of 5-hydroxytryptamine(2A) receptor (Ki = 0.81 nM).


PHELLIGRIDIN G

An organic heterotricyclic compound isolated from the fruiting bodies of the fungus Phellinus igniarius.


alangimarckine

A member of the class of beta-carbolines that is tubulosan bearing methoxy groups at positions 10 and 11 as well as a hydroxy group at position 9.


strigolactone

A family of sesquiterpene lactones with a common structure consisting of two lactone moieties (one a butenolide, the other a tricyclic gamma-lactone) connected by an enol-ether bridge. Originally used to describe phytohormones with diverse signaling activities, biosynthesised from carotenoids, the term also includes synthetic analogues.


A member of the class of dibenzofurans that is dibenzo[b,d]furan substituted by a hydroxy group at position 3 and chloro groups at positions 2, 4, 7, 8 and 9 respectively.


14-deacetyl astellolide A

Major species at pH 7.3.


An organic heterotricyclic compound that is N,1,4,4-tetramethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide substituted by a [2-methyl-4-(4-methylpiperazin-1-yl)phenyl]nitrilo group at position 8.


(+)-angenomalin

A furanocoumarin that is 8,9-dihydro-2H-furo[2,3-h][1]benzopyran-2-one carrying a prop-1-en-2-yl substituent at position 8.


BATZELLADINE A

A carboxylic ester obtained by the formal condensation of (2aS,3S,4R,7R,8aS)-4-methyl-7-nonyl-2,2a,3,4,6,7,8,8a-octahydro-1H-5,6,8b-triazaacenaphthylene-3-carboxylic acid with the hydroxy group of 4-carbamimidamidobutyl (3R)-3-(9-hydroxynonyl)-1-imino-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carboxylate. Isolated from a bright red Caribbean sponge, Batzella, it has potential anti-HIV activity.


propiomazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2.


fumisoquin A

A pyridoisoquinoline that is (11aR)-1,3,4,6,11,11a-hexahydro-2H-pyrido[1,2-b]isoquinoline substituted by hydoxy groups at positions 1S,7,8 and 11R, by an amino group at position 3S and an oxo group at position 4. It is produced by a biosynthetic gene cluster called fsq in the human pathogen Aspergillus fumigatus.


lactucopicrin 15-oxalate

A sesquiterpene lactone obtained by formal condensation of one of the carboxy groups of oxalic acid with the 15-hydroxy group of lactucopicrin. Found in chicory.


fumisoquin B

A pyridoisoquinoline that is (11aR)-1,3,4,6,11,11a-hexahydro-2H-pyrido[1,2-b]isoquinoline substituted by hydoxy groups at positions 1S,7 and 11R, by an amino group at position 3S, oxo group at position 4 and a sulfooxy group at position 8. It is produced by a biosynthetic gene cluster called fsq in the human pathogen Aspergillus fumigatus.


callophycoic acid A

A dibenzooxepine diterpenoid that is hexahydrodibenzo[b,e]oxepine with an isolated double bond between positions 6a and 7 and is substituted by a bromo, a carboxy, a 3E-4,8-dimethylnona-3,7-dien-1-yl and a methyl group  at positions 9, 2, 10 and 10 respectively (the 9S,10S,10aR stereoisomer). It is isolated from the Fijian red alga Callophycus serratus and exhibits antibacterial, antimalarial and anticancer activities.


CANDIDUSIN C

A member of the class of dibenzofurans that is dibenzo[b,d]furan substituted by methoxy groups at positions 6 and 9, hydroxy groups at positions 2 and 3 and a 4-methoxyphenyl group at position 7. It has been isolated from Aspergillus taichungensis.


name: L-cysteinyl sulfurated eukaryotic molybdenum cofactor(2-)

description: MoCo in eukaryotic sulfite oxidase.


(R)-tianeptine

The R-enantiomer of tianeptine.


zaluzanin D

A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and an acetlyoxy group at position 8. Isolated from Zaluzania triloba and Laurus nobilis, it exhibits trypanocidal activity.


FONSECINONE A

A dimeric naphthopyran with formula C32H26O10, originally isolated from Aspergillus niger.


imidazobenzodiazepine

Any organic heterotricyclic compound that is any benzodiazepine which is ortho-fused with a imidazole.


urolithin A 8-O-glucuronide

A member of the class of benzochromenones that is urolithin A in which the phenolic hydrogen at position 8 has been replaced by a beta-D-glucuronosyl group.


ARTOCHAMIN C

An extended flavonoid that is 4H,8H-pyrano[2,3-f]chromen-4-one substituted by a 3,4-dihydroxyphenyl group at position 2, hydroxy group at position 5 and geminal methyl groups at position 8. It is isolated from the roots of Artocarpus chama and exhibits cytotoxicity against a panel of human tumour cell lines like breast adenocarcinoma, ovarian carcinoma, ileocecal carcinoma and melanoma.


colforsin daropate

A carboxylic ester resuting from the formal condensation of the carboxy group of N,N-dimethyl-beta-alanine with the 6-hydroxy group of forskolin. It is an adenylate cyclase activator.


CHAETOVIRIDIN E

An  azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a methyl group at position 6a, a 2-methylbut-2-enoyl group at position 9 and a 3-methylpent-1-en-1-yl group at position 3. It has been isolated from Chaetomium globosum.


(13R)-manoyl oxide

A tricyclic labdane diterpenoid that is an intermediate in the biosynthesis of forskolin by Coleus forskohlii.


ANNOMONTINE

An alkaloid that is beta-carboline substituted at position C-1 by a 2-aminopyrimidin-4-yl moiety. An antiparasitic agent found in Annona montana and Annona foteida.


CTBT

An organic heterotricyclic compound that is tetrazolo[5,1-c][1,2,4]benzotriazine substituted at position 7 by a chloro group. An antifungal and chemosensitising agent that induces oxidative stress in yeast and filamentous fungi and enhances the cytotoxic activity of 5-fluorocytosine and azole antimycotics.


jacozine

A pyrrolizine alkaloid that is seneciphylline in which the exocyclic double bond has been converted to the corresponding epoxide.


tetraneurin E

A sesquiterpene lactone that is a (3aS,9bS)-3-methylidenedecahydroazuleno[4,5-b]furan-2(3H)-one heterotricyclic ring system with a hydroxymethyl, hydroxy, acetate, and methyl group substituents at positions 6, 6a, 9, and 9a respectively.


THIOXANTHENE

A thioxanthene that consists of a xanthene skeleton in which the oxygen atom is replaced by a sulfur atom.


OCHROCARPIN C

A furanocoumarin that is 2H-furo[2,3-h]chromen-2-one substituted by a hydroxy group at position 5, 2-hydroxypropan-2-yl group at position 8, a 2-methylpropanoyl group at position 6 and a phenyl group at position 4. Isolated from the bark of Ochrocarpos punctatus, it exhibits cytotoxicity against the A2780 ovarian cancer cell line.


LUMICHROME

A compound showing blue fluorescence, formed by a photolysis of riboflavin in acid or neutral solution.


A member of the class of cyclobutadipyrimidines that is 1,4a,4b,8,8a,8b-hexahydrocyclobuta[1,2-d:4,3-d']dipyrimidine-2,7-dione carrying two additional amino substituents at positions 4 and 5.


santonin

A  santonin that is 3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione substituted by methyl groups at positions 3, 5a and 9.


A dibenzodioxonine isolated from the culture broth of Penicillium asperosporum that acts as an acyl-CoA:cholesterol acyltransferase inhibitor. It is one of the 8 possible diastereomers of AS-186c. However the exact stereochemistry of the compound is unknown.