Decreased Peak Expiratory Flowrate

description: Decreased expiratory peak flow measurement achieved during forced expiration that primarily reflects changes in upper airway conductance and may be of limited use in evaluation of changes in peripheral airway conductance. Evaluation of peak flow performance is subjective, and, therefore, acceptability criteria are lacking. Because the maneuver is effort and volume dependent, the patient must be encouraged to perform as vigorously as clinically feasible. The results of subjective evaluation may be difficult to interpret consistently. A validated dyspnea rating scale may be useful.


Prolonged Acceleration

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A fetal heart rate acceleration that lasts 2 to less than 10 minutes.


Demyelination

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Breakdown, or abnormal development, of a nerve fiber myelin sheath.


Atrial perforation

description: A rupture in atrial tissue due to traumatic or pathologic processes.


Reduced Blood Flow

description: Inadequate blood flow.


Acquired Growth Hormone Deficiency

description: Growth hormone deficiency that is not present at birth; this condition may result from a variety of causes such as intracranial tumors or their treatment, infection, trauma or other cause.


Early Repolarization

description: An electrocardiographic finding of J point and ST segment elevation in the absence of other signs of acute ischemia or pericarditis. (CDISC)


Poor Feeding

description: Occurs either when an infant shows no interest in feeding or when there is an inability to take in adequate nutrition. Poor feeding is a nonspecific symptom of many disorders, including neurological, genetic, structural, metabolic, and infectious diseases.


Cardiovascular System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the cardiovascular system.


Urostomy Leakage

description: Leakage of contents from a urostomy.


Second trimester bleeding

description: Excessive blood loss within the second trimester but prior to onset of labor.


Peak E Velocity

description: The maximum rate of blood flow across a cardiac valve during early diastole (passive ventricular filling).


Superior vena cava stenosis

description: Abnormal narrowing of the lumen of the superior vena cava.


Fetal Stem Vessel Thrombus

description: A focus of thrombus adhered to the wall of a fetal stem vessel. It can be completely or partially obstructive and may lead to avascular villi.


Hemorrhage of colon

description: Bleeding originating from the colon.


name: Left Ventricular Conduction Delay by ECG Finding

description: An electrocardiographic finding in which there is evidence that electrical transmission through the left ventricle is impaired. (CDISC)


name: Untreated Central Nervous System Neoplasm

description: A finding of central nervous system neoplasm that has not been treated.


Cold Sensation

description: An internal feeling of being cooler without a concomitant change in the ambient environment. (ACC/AHA)


Decreased Bladder Compliance

description: The loss of elasticity of the bladder wall with increased urine volume.


Injury to Inferior Vena Cava

description: Damage to the inferior vena cava from traumatic or pathologic processes.


name: Heart Chamber Volume at End Ventricular Systole

description: The volume of blood remaining in a heart chamber at end ventricular systole.


Immune System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the immune system.


Syncope Related to COVID-19

description: Syncope in a patient with probable or confirmed acute COVID-19.


Paroxysmal hypertension

description: Hypertension that presents intermittently.


name: High Risk Muscle Invasive Bladder Urothelial Carcinoma

description: A finding indicating the presence of a high risk bladder urothelial carcinoma invading into the bladder muscularis propria.


Sinus Tachycardia by ECG Finding

description: An electrocardiographic finding of abnormally rapid heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC)


Cyst of parathyroid

description: An epithelium-lined, fluid-filled cyst containing parathyroid hormone that is usually located in an inferior parathyroid gland, but may be found in other locations in the neck or mediastinum.


Malignant pericardial effusion

description: Presence of fluid in the pericardial space as a complication of malignant disease.


Choristoma of eye proper

description: A rare developmental abnormality characterized by the presence of histologically mature tissue located in the epibulbar area.


Laceration of esophagus

description: A torn, ragged, mangled wound, or an accidental cut of esophagus.


name: No Superior Movement of Thyroid Cartilage During Swallowing

description: A finding of no superior movement of thyroid cartilage during swallowing.


Bladder hemorrhage

description: Bleeding originating from the urinary bladder wall.


name: Perinatal Central Nervous System Depression

description: Generalized depression of the central nervous system of an infant during the perinatal period.


Eye Irritation

description: A generic term used to describe abnormal sensations that bother the eyes like dryness, itchiness, burning and grittiness.


Aortic Coarctation Severity

description: The qualitative measurement of the severity of the aortic coarctation.


Fetal Position below Umbilicus

description: A reference point for the fetal position when the fetal heart rate is detected below the mother's umbilicus.


Miscarriage in first trimester

description: Pregnancy loss at less than 14 weeks 0 days gestation.


Pregnancy Related Breast Soreness

description: The tenderness of the breasts during pregnancy due to changes in the hormonal levels and increased breast tissue growth.


Hemoconcentration

description: An increase in the concentration of blood cells resulting from the loss of plasma or water from the blood stream.


Polypoid sinus degeneration

description: Recurrent nasal polyps with subsequent destruction of the nasal pyramid.


name: Fish-Mouth Papilla with Mucin Hypersecretion

description: An endoscopic finding indicating the presence of a wide-opened papilla filled with mucin.


Hemorrhage from ureter

description: Bleeding originating from the ureter.


Reverse Split S1 Heart Sound

description: An auscultated finding in which the tricuspid valve closure sound occurs before the mitral closure sound. (ACC/AHA)


name: Ectopic Ventricular Rhythm by ECG Finding

description: An electrocardiographic finding of three or more consecutive complexes of ventricular origin. The QRS complexes are wide and have an abnormal morphology. (CDISC)


Head and Neck Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the head and neck.


name: Untreated Childhood Anaplastic Oligoastrocytoma

description: A finding of anaplastic oligoastrocytoma in childhood that has not been treated.


name: West Haven Hepatic Encephalopathy Grade 4

description: Coma - symptoms or pathological characteristics include coma with or without response to painful stimuli. (Adapted from: Hepatic Encephalopathy. David C Wolf. http://emedicine.medscape.com/article/186101-overview.)


Dissecting Thoracic Aortic Aneurysm

description: A dissecting aneurysm formed between the intimal and medial layers of the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.


name: Clinical Distant Metastasis ENSAT Staging Finding v7

description: A clinical finding about one or more characteristics of adrenal cancer, following the rules of the ENSAT staging v7 classification system as they pertain to distant metastases.


name: Myasthenia Gravis Foundation of America Class IVB

description: Myasthenia gravis presenting with severe weakness predominantly affecting oropharyngeal, respiratory muscles, or both. May also have lesser or equal involvement of limb, axial muscles, or both.


Biliary Anastomotic Leakage

description: Leakage of bile due to breakdown of a biliary anastomosis.


Dark Small Macules and Papules Present

description: A finding in which a variable number of darkly pigmented small macules and papules are present in a skin nevus.


Fetal Finding

description: Any intrauterine symptom or result related to the fetus.


name: Incomplete Right Bundle Branch Block by ECG Finding

description: An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration less than 120 ms. (CDISC)


Coronary Culprit Lesion

description: The lesion considered to be responsible for the acute coronary syndrome. (ACC)


name: Severely Abnormal Ventricular Ejection Fraction

description: Severely less than normal amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered less than 30%.


Recurrent Deceleration

description: Fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute timeframe. Applies to early, late or variable decelerations.


Disturbance in Bowel Function

description: Abnormal functioning of the small and/or large intestine.


Double Capsule

description: The presence of two distinct capsular layers around an implant with an intercapsular space of the breast.


name: Apparent Sporadic Paraganglioma or Pheochromocytoma

description: A paraganglioma-pheochromocytoma that is not associated with a clear genetic mutation.


name: Unfavorable Intermediate Risk Prostate Carcinoma

description: Intermediate risk prostate carcinoma in which the prostate carcinoma-specific mortality and all-cause mortality rates are similar to the rates observed in high-risk prostate carcinoma.


Aortic Postductal Coarctation Severity

description: The assessment of the severity of postductal aortic coarctation.


name: Refractory Soft Tissue Sarcoma, Excluding Rhabdomyosarcoma

description: A finding indicating the presence of a sarcoma arising from the soft tissue, other than rhabdomyosarcoma, that is resistant to treatment.


Postoperative Delayed Gastric Emptying

description: Delayed stomach emptying as a result of surgery.


name: Unifocal Atrial Premature Complex by ECG Finding

description: An electrocardiographic finding of premature atrial complexes which have a single distinct morphology, suggesting origin at one atrial site.


Untreated Childhood Oligoastrocytoma

description: A finding of oligoastrocytoma in childhood that has not been treated.


Back Injuries

description: Trauma to the posterior trunk.


Brain Concussion

description: A violent jar or shock, or the condition which results from such an injury.


name: Frequent Premature Ventricular Complexes by ECG Finding

description: An electrocardiographic tracing demonstrating frequent premature ventricular contractions that exceed an acceptable, predetermined threshold. Different thresholds may apply to different patient populations.


name: Skin Integrity Changes Secondary to Cutaneous Metastases


pT2 ENSAT Staging Finding v7

description: Adrenal cancer with tumor size more than 5.0 cm. There is no invasion of tissues outside the adrenal gland. (7th Ed, 2009)


Biliary Leak

description: Sudden unexpected leakage of bile from the liver or soft tissue.


name: Idiopathic Primary Ventricular Tachycardia/Ventricular Flutter by ECG Finding

description: An electrocardiographic finding of ventricular tachycardia or ventricular fibrillation of unknown cause. (ACC)


Acquired chylothorax

description: Chylothorax that results from malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, or sarcoidosis.


Vertex Presentation

description: A fetal presentation where the head is presenting first in the pelvic inlet. Does not apply if compound or breech presentation or if brow, face, hand, shoulder, etc. present first in the pelvic inlet. (reVITALize)


Periodic Fetal Heart Rate Pattern

description: Fetal heart rate patterns associated with maternal uterine contractions.


Respiratory System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the respiratory system.


Refractory Erectile Dysfunction

description: Erectile dysfunction that does not respond to treatment.


name: Complete Inversion of Epiglottis During Swallowing

description: A finding of complete inversion of epiglottis during swallowing.


name: Escape to Nasal Cavity During Swallowing

description: A finding of escape to nasal cavity during swallowing.


Post Term Birth

description: Birth at greater than or equal to 42 weeks and 0 days.


Level of Consciousness

description: The level of awareness of an organism.


name: Locally Advanced Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Acquired Melanocytic Nevus

description: A benign nevus that arises from the vulva during childhood and grows with increasing age.


COCARBOXYLASE

An organic chloride salt of thiamine(1+) diphosphate.


name: Post-Immunization Arthropathy, Right Knee

description: Evidence of post-immunization arthropathy in the right knee.


A trifluoroacetamide resulting from the formal condensation of the amino group of 8-aminooctan-1-ol with trifluoroacetic acid.


The stable isotope of vanadium with relative atomic mass 50.943964, 99.8 atom percent natural abundance and nuclear spin 7/2.


A diarylheptanoid that is (6E)-6-hepten-3-ol substituted by a 3,4-dihydroxyphenyl group at position 1 and a 4-hydroxyphenyl group at position 7 (the 3R-stereoisomer). It has been isolated from the rhizomes of Curcuma kwangsiensis.


ETHIRIMOL

An aminopyrimidine that is 2-ethylaminopyrimidin-4-one carrying butyl and methyl substituents at positions 5 and 6 respectively. A fungicide first marketed in 1970 and used as a seed treatment for diseaases such as damping-off, it is not licensed for use within the European Union.


pyrimidine fungicide

Any pyrimidine antifungal agent that has been used as a fungicide.


anilinopyrimidine fungicide

Any pyrimidine fungicide in which the pyrimidine ring is substituted by the nitrogen of an aniline moiety.


diflumetorim

A racemate comprising equimolar amounts of (R)- and (S)-diflumetorim.  Used mainly to control powdery mildew and rust on ornamental crops.


NUARIMOL

A racemate comprising equimolar amounts of (R)- and (S)-nuarimol. A sterol demethylation inhibitor, it is used as a systemic fungicide but is not approved for use within the European Union.


FERIMZONE

A member of the class of pyrimidines that is 2-hydrazino-4,6-dimethylpyrimidine in which the two amino hydrogens are replaced by a 1-(2-methylphenyl)ethylidene group. It is used for the control of fungal diseases in rice.


DIMETHIRIMOL

A member of the class of aminopyrimidines that is 2-dimethylaminopyrimidine carrying methyl, butyl and hydroxy substituents at posiitons 4, 5 and 6 respectively. A fungicide first marketed in 1970, and used particularly in glasshouses to control powdery mildew, it is no longer approved for use within the European Union.


BUPIRIMATE

A member of the class of aminopyrimidines that is 2-ethylaminopyrimidine carrying methyl, butyl and dimethylaminosulfooxy substituents at posiitons 4, 5 and 6 respectively.


Grade 3 Tooth Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Tooth Infection, CTCAE

description: A disorder characterized by an infectious process involving a tooth.


Grade 4 Tooth Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 5 Tooth Infection, CTCAE

description: Death


Grade 2 Tooth Infection, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Mucous polyp of cervix

description: A polypoid lesion that arises from the cervix and contains mucus.


name: Grade 2 Lower Gastrointestinal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Appendiceal Carcinoma pN1 TNM Finding v7

description: Appendiceal carcinoma with metastasis in 1-3 regional lymph nodes. (from AJCC 7th Ed.)


17-octadecynoic acid

An acetylenic fatty acid that is octadecanoi acid (stearic acid) which has been doubly dehydrogenated at positions 17 and 18 to give the corresponding alkynoic acid.


WHO Grade 1 Glioma

description: A category of low grade gliomas that includes subependymal giant cell astrocytoma, pilocytic astrocytoma, angiocentric glioma, and subependymoma.


Adult Myxopapillary Ependymoma

description: A myxopapillary ependymoma that occurs during adulthood.


Adult Pilocytic Astrocytoma

description: A pilocytic astrocytoma occurring in adults.


Recurrent WHO Grade 1 Glioma

description: The reemergence of WHO grade 1 glioma after a period of remission.


Adult Subependymoma

description: A subependymoma that occurs during adulthood.


Refractory WHO Grade 1 Glioma

description: WHO grade 1 glioma that is resistant to treatment.


name: Adult Subependymal Giant Cell Astrocytoma

description: A subependymal giant cell astrocytoma occurring in adults.


Childhood Myxopapillary Ependymoma

description: A myxopapillary ependymoma that occurs during childhood.


name: Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Perinatal intracranial hemorrhage

description: Bleeding within the skull of a newborn infant occurring around the time of birth.


Perinatal intraventricular hemorrhage

description: Bleeding within the cerebral ventricles occurring around the time of birth.


name: Perinatal subependymal hemorrhage with intraventricular and intracerebral extension

description: A hemorrhage that involves the subependymal region, the lateral cerebral ventricles and the brain tissue occurring around the time of birth.


Subependymal haemorrhage

description: Bleeding within the subependymal germinal matrix.


name: Intraventricular hemorrhage of prematurity

description: Bleeding within the cerebral ventricles in a preterm infant.


Intracranial tumor hemorrhage

description: A  brain hemorrhage caused by an intracranial tumor.


name: Intraventricular Hemorrhage Related to Birth

description: Bleeding into the cerebral ventricles that occurs during labor and/or delivery.


name: Grade 2 Intraventricular Hemorrhage of the Newborn

description: Bleeding into the lateral cerebral ventricles of a newborn infant without acute ventricular dilatation.


name: Intraventricular (nontraumatic) hemorrhage, grade 3, of fetus and newborn

description: Bleeding into the lateral cerebral ventricles of a newborn infant with ventricular dilatation directly attributable to the acute bleeding.


name: Intracranial Hemorrhage Related to Birth

description: Bleeding within the skull of a newborn infant occurring during labor and/or delivery.


name: Intraventricular Hemorrhage with Parenchymal Hemorrhage of the Newborn

description: Bleeding into the lateral cerebral ventricles and the adjacent brain tissue of a newborn infant.


Cerebral Hemorrhage Related to Birth

description: Intracranial bleeding in the tissue of the cerebrum of a newborn infant occurring during labor and/or delivery.


name: 1,2-Cyclohexanedicarboxylic acid, 2-methylpent-3-yl nonyl ester


name: Grade 3 Ovary Intra-Operative Injury, CTCAE


Gastric Cancer pN2 TNM Finding v6

description: Gastric cancer with evidence of metastasis in 7-15 regional lymph nodes. (from AJCC 6th Ed.)


Parotid Gland Warthin Tumor

description: An adenoma that arises from the parotid gland. It is characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland.


An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of oscr#19.


An alpha-D-glucosyl-(1->4)-D-mannopyranose in which the anomeric hydroxy group has alpha configuration.


Skin Cavernous Hemangioma

description: A cavernous hemangioma arising from the skin.


17-epiestriol 16-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is 17-epiestriol having a single beta-D-glucuronic acid residue attached at position 16.


name: Other Stimulant Abuse with Unspecified Stimulant-Induced Disorder

description: Evidence of other stimulant abuse with unspecified stimulant-induced disorder not specified elsewhere.


ANTHRARUFIN

A  dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 5.


Penile Lymphoepithelioma-Like Carcinoma

description: A variant of penile squamous cell carcinoma characterized by the presence of islands of malignant cells with uniform vesicular nuclei and prominent nucleoli, and a dense lymphocytic infiltrate.


Penile Carcinoma Cuniculatum

description: A variant of verrucous carcinoma of the penis. It is characterized by a labyrinthine growth pattern.


Penile Lymphoma

description: A lymphoma that arises from penile skin, subcutis, corpora cavernosa, and spongiosum. Diffuse large B-cell lymphoma is the most common primary penile lymphoma. (WHO 2016)


Stage 0is Penile Cancer AJCC v8

description: Stage 0is includes: Tis, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Refractory Penile Carcinoma

description: Penile carcinoma that is resistant to treatment.


Penile Lymphangioma

description: A lymphangioma that occurs in the skin of the penis.


Childhood Malignant Penile Neoplasm

description: A rare malignant neoplasm of the penis that occurs during childhood.


Stage IIA Penile Cancer AJCC v8

description: Stage IIA includes: (T1b, N0, M0); (T2, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Penile Cancer AJCC v8

description: Stage III includes: IIIA: T1-3, N1, M0; IIIB: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N1: Penile cancer with two or less unilateral inguinal metastases, no extranodal extension. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


Penile Hemangioma

description: A hemangioma that occurs in the skin of the penis.


name: Grade II Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower two thirds of the epithelial thickness.


Penis carcinoma recurrent

description: A carcinoma of the penis that reappears after a period of remission.


Unresectable Penile Carcinoma

description: Penile carcinoma that is not amenable to surgical resection.


Penile Mucosal Melanoma

description: A melanoma that arises from the mucosa of the penis.


name: Penile Human Papillomavirus-Independent Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the penis and is not caused by human papillomavirus infection. Morphologic variants include pseudohyperplastic, pseudoglandular, verrucous, papillary, and sarcomatoid carcinoma.


Penile intraepithelial neoplasia

description: A precancerous neoplastic lesion that arises from the penis. It is characterized by dysplastic changes of the squamous epithelium with an intact basement membrane.


Bowenoid papulosis of penis

description: A cutaneous, usually multifocal lesion in the penis characterized by the presence of verrucous papules.  It is caused by human papillomavirus infection.  Morphologically there is bowenoid dysplasia present.  Progression to invasive carcinoma is infrequent.


Penile Schwannoma

description: A schwannoma that occurs in the penis.


Myointimoma

description: A rare benign mesenchymal neoplasm that occurs in the glans and corpora of the penis. It is characterized by the proliferation of spindle-shaped myofibroblasts in the intravascular spaces.


Penile Neurofibroma

description: A neurofibroma that occurs in the penis.


name: Basaloid (Undifferentiated) Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by full-thickness replacement of the squamous epithelium by immature, small, monotonous, basophilic cells. The cells have round to oval nuclei, inconspicuous nucleoli, and scant cytoplasm. Apoptosis and mitotic figures are prominent. (WHO 2016)


Stage IV Penile Cancer AJCC v8

description: Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1). T4: Penile cancer with tumor invading into adjacent structures (i.e., scrotum, prostate, pubic bone). N3: Penile cancer with extranodal extension of lymph node metastases or pelvic lymph node metastases. M1: Distant metastasis present. (AJCC 8th ed.)


name: Penile Clear Cell Squamous Cell Carcinoma

description: A variant of penile squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm.


name: Penile Squamous Cell Carcinoma, Not Otherwise Specified

description: A penile squamous cell carcinoma characterized by the absence of special morphologic features and lack of information on p16 immunohistochemistry and human papilloma virus testing status.


name: Warty (Bowenoid) Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by a slightly spiking papillomatous surface with atypical parakeratosis. There is prominent cellular pleomorphism, koilocytosis, and mitoses. Unlike in basaloid penile intraepithelial neoplasia, there is squamous maturation. (WHO 2016)


Stage IIIA Penile Cancer AJCC v8

description: Stage IIIA includes: T1-3, N1, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N1: Penile cancer with two or less unilateral inguinal metastases, no extranodal extension. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Penile Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Condyloma Acuminatum

description: A human papillomavirus-related benign neoplasm affecting the penis. Most often it arises from the glans penis in young men. It usually presents with a nodular wart. Morphologically, it is characterized by an exophytic papillary proliferation of squamous cells and acanthosis. Most cases either resolve spontaneously or do not recur following removal.


Penile Adenosquamous Carcinoma

description: An extremely rare carcinoma that arises from the penis and is characterized by the presence of glandular and squamous components.


Penile Cancer by AJCC v8 Stage

description: A term that refers to the staging of penile cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to penile squamous cell carcinoma and associated histologic subtypes. It does not apply to urethral carcinomas, sarcomas, and melanomas. (from AJCC 8th Ed.)


name: Unresectable Penile Squamous Cell Carcinoma

description: Penile squamous cell carcinoma that is not amenable to surgical resection.


Penile Cutaneous Melanoma

description: A melanoma that arises from the skin of the penis.


name: Differentiated penile intraepithelial neoplasia

description: Intraepithelial neoplasia of the penis that is not caused by human papillomavirus infection. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present. It is characterized by a thickened epithelium, subtle abnormal cellular maturation, and atypical basal layer cells. Parakeratosis is common. (WHO 2016)


Penile Pseudohyperplastic Carcinoma

description: A multifocal, extremely differentiated squamous cell carcinoma of the penis. It typically occurs in older patients and is associated with lichen sclerosus.


Adult Penile Carcinoma

description: A carcinoma of the penis that occurs during adulthood.


Penile Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that occurs in the penis.


Penile Leiomyoma

description: A leiomyoma that occurs in the penis.


Penile Soft Tissue Neoplasm

description: A rare mesenchymal neoplasm that arises from the penis.


Penile Pseudoglandular Carcinoma

description: A penile squamous cell carcinoma characterized by the formation of gland-like structures.


Stage 0 Penile Cancer AJCC v8

description: Stage 0 includes: 0is: Tis, N0, M0; 0a: Ta, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Penile Cancer AJCC v8

description: Stage IIIB includes: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


name: Human Papillomavirus-Related Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis caused by human papillomavirus infection.


name: Penile Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant peripheral nerve sheath tumor that occurs in the penis.


Penile Papillary-Basaloid Carcinoma

description: A variant of penile basaloid squamous cell carcinoma. It is characterized by a papillary exophytic or endophytic growth pattern.


Stage 0a Penile Cancer AJCC v8

description: Stage 0a includes: Ta, N0, M0. Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Low Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower one third of the epithelial thickness.


Penile Epithelioid Hemangioma

description: An epithelioid hemangioma that occurs in the skin of the penis.


name: High Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy either the lower two thirds of the epithelial thickness (grade II) or the entire thickness of the epithelium (grade III, Bowen atypia, or squamous cell carcinoma in situ).


Stage II Penile Cancer AJCC v8

description: Stage II includes: IIA: (T1b, N0, M0); (T2, N0, M0); IIB: (T3, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Warty-Basaloid Carcinoma

description: A squamous cell carcinoma that arises from the penis. It is characterized by warty (condylomatous) and basaloid features.


Penile Angiosarcoma

description: A rare angiosarcoma that affects the penis.


name: Warty-Basaloid Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by the presence of a variable mixture of warty and basaloid cells. (WHO 2016)


melanoma of penis

description: A melanoma that arises from the penis. It may be cutaneous or mucosal. The most common site of involvement is glans penis.


Metastatic Penile Cancer

description: Carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Stage I Penile Cancer AJCC v8

description: Stage I includes: T1a, N0, M0. T1a: Penile cancer with tumor without lymphovascular invasion or perineural invasion and is not high grade (i.e., grade 3 or sarcomatoid). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Mucoepidermoid Carcinoma

description: An extremely rare carcinoma that arises from the penis and is characterized by the presence of mucinous and squamous components.


Penile Rhabdomyosarcoma

description: A rhabdomyosarcoma that occurs in the penis. It usually affects young children. Embryonal rhabdomyosarcoma is the most common type.


Locally Advanced Penile Carcinoma

description: Penile carcinoma that has spread to nearby tissues or lymph nodes.


Grade 2 Dysphagia, CTCAE

description: Symptomatic and altered eating/swallowing


nitrogen-13 atom

The radioactive isotope of nitrogen with relative atomic mass 13.0057386. The longest-lived nitrogen radionuclide with half-life of 9.965 min.


nitrogen-14 atom

The stable isotope of nitrogen with relative atomic mass 14.003074. The most abundant (99.63 atom percent) isotope of naturally occurring nitrogen.


nitrogen-15 atom

The stable isotope of nitrogen with relative atomic mass 15.000109. The least abundant (0.368 atom percent) isotope of naturally occurring nitrogen.


Current Hepatitis B Infection

description: Hepatitis B infection is evident at the time of testing.


name: Other Rheumatoid Arthritis with Rheumatoid Factor of Unspecified Ankle and Foot

description: Evidence of other rheumatoid arthritis with rheumatoid factor of unspecified ankle and foot not specified elsewhere.


6-phospho-D-gluconic acid

A gluconic acid phosphate having the phosphate group at the 6-position. It is an intermediate in the pentose phosphate pathway.


N-hexacosenoylsphingosine

An N-acylsphingosine in which the acyl moiety contains 26 carbons and 1 double bond.


name: Grade 3 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


A branched hexasaccharide comprised of five alpha-D-mannose residues linked as shown and also to a 3-deoxy-alpha-D-manno-oct-2-ulosonic acid (3-deoxy-D-manno-oct-2-ulosonic acid; Kdo) residue at the reducing end, corresponding to the core oligosaccharide of the phytopathogenic bacterium Rhizobacterium radiobacter strain Rv3.


Acute Intrapartum Hypoxic Event

description: A sentinel hypoxic event occurring during labor, with evidence of fetal metabolic acidosis in the fetal umbilical arterial blood; a sudden and sustained fetal bradycardia or the absence of fetal heart rate variability in the presence of persistent, late, or variable decelerations (category III tracing); previously normal Apgar scores that are 0-3 beyond 5 minutes.


2-(acetamidomethylidene)succinic acid

A dicarboxylic acid that is succinic acid substituted by a acetamidomethylidene group at position 2.


Stage IIIB Anal Cancer AJCC v8

description: Stage IIIB includes: T4, N0, M0. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


opioid dependence with withdrawal

description: Evidence of opioid dependence with withdrawal.


cis-10-pentadecenoic acid

The cis-isomer of pentadec-10-enoic acid.


Ala-Met-Asp-Tyr

A tetrapeptide composed of L-alanine, L-methionine, L-aspartic acid and L-tyrosine joined in sequence by peptide linkages.


A member of the class of imidazoles bearing methyl, amino and selenocarboxamido substituents at positions 1, 4 and 5 respectively.


Met-His

A dipeptide formed from L-methionine and L-histidine residues.


An Fe4S4 iron-sulfur cluster in which each sulfur is attached to three of the iron atoms.


Esophageal Fistula

description: An abnormal communication between the esophagus and another organ or anatomic site.


Ile-Gly

A dipeptide formed from L-isoleucine and glycine residues.


name: Diabetes Mellitus due to Underlying Condition with Hyperosmolarity with Coma

description: Evidence of diabetes mellitus due to underlying condition with hyperosmolarity with coma.


5-iododeoxycytidine triphosphate

A 2'-deoxycytidine phosphate that is 2'-deoxycytidine-5'-triphosphate in which the hydrogen at position 5 on the cytosine ring is replaced by iodine.


A glucotriose consisting of two beta-D-glucopyranose residues and a D-glucopyranose residue joined in sequence by (1->6) and (1->4) glycosidic bonds.


glucotriose

Any trisaccharide composed of 3 glucose moieties.


isomaltotriose

A glucotriose consisting of two alpha-D-glucopyranose residues and a D-glucopyranose residue joined in sequence by (1->6) glycosidic bonds.


A glucotriose consisting of two alpha-D-glucose residues and a beta-D-glucose at the reducing end in a linear sequence and joined by (1->6) linkages.


isobemisiose

A glucotriose that is alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranoside in which the anomeric hydroxy group has been converted into the corresponding alpha-D-glucopyranoside. An unusual trisaccharide abundant in the silverleaf whitefly, Bemisia argentifolii.


A glucotriose consisting of two molecules of alpha-D-glucopyranose and a D-glucopyranose moiety joined together in sequence by (1->4) and (1->3) glycosidic bonds.


A glucotriose consisting of alpha-D-glucopyranose, beta-D-glucopyranose and D-glucopyranose residues joined in sequence by (1->6) glycosidic bonds.


A glucotriose consisting of three glucose units connected via alpha-(1->3) linkages. Also known as nigerotriose.


A glucotriose consisting of three D-glucose units joined by beta-(1->2)-linkages


A glucotriose consisting of three molecules of beta-D-glucopyranose joined in a linear sequence by 1->2 glycosidic linkages.


A glucotriose consisting of three molecules of beta-D-glucopyranose joined in a linear sequence by 1->6 glycosidic linkages.


A glucotriose consisting of beta-D-glucopyranose, alpha-D-glucopyranose and D-glucopyranose residues joined in sequence by (1->3) and (1->2) glycosidic bonds.


A glucotriose consisting of three alpha-D-glucopyranose residues joined in sequence by (1->6) and (1->4) glycosidic bonds.


A glucotriose consisting of a beta-D-glucopyranose residue and two alpha-D-glucopyranose residues joined in sequence by (1->4) and (1->1) glycosidic bonds.


A glucotriose that is D-glucopyranose in which the hydroxy groups at positions 2 and 6 have been converted into the corresponding D-glucopyranosyl derivatives.


A glucotriose consisting of alpha-D-glucopyranose, D-glucopyranose and beta-D-glucopyranose residues joined in sequence by (1->3) and (1->2) glycosidic bonds.


A glucotriose composed of three beta-D-glucose units joined by two (1->3)-linkages.


A glucotriose consisting of alpha-D-glucopyranose in which the hydroxy groups at 2 and 3 have each been converted into the corresponding beta-D-glucopyranosyl derivatives.


A glucotriose consisting of three molecules of alpha-D-glucopyranose joined in a linear sequence by 1->6 glycosidic linkages.


A glucotriose consisting of three molecules of beta-D-glucopyranose joined in a linear sequence by (1->4) and (1->6) glycosidic linkages.


A glucotriose that is D-glucopyranose in which the hydroxy groups at positions 3 and 6 have each been converted into the corresponding beta-D-glucopyranosyl derivative.


A glucotriose consisting of alpha-D-glucopyranose, beta-D-glucopyranose and D-glucopyranose attached in sequence by (1->2) and (1->6) glycosidic linkages.


A maltotriose trisaccharide in which the glucose residue at the reducing end is in the pyranose form.


A glucotriose that is alpha-D-glucopyranose in which the hydroxy groups at positions 2 and 4 have been converted to the corresponding alpha-D-glucopyranosyl and beta-D-glucopyranosyl derivatives, respectively.


A glucotriose that is D-glucopyranose in which the hydroxy groups at positions 2 and 6 have each been converted into their corresponding alpha-D-glucopyranosyl derivative.


A glucotriose consisting of two beta-D-glucopyranosyl residues and a D-glucopyranose residue joined in sequence by (1->2) and (1->4) glycosidic bonds.


A glucotriose consisting of one beta-D-glucose and two alpha-D-glucose residues linked sequentially (1->4) and (1->2).


A glucotriose that is D-glucopyranose in which the hydroxy groups at positions 4 and 6 have been converted into the corresponding beta-D-glucopyranoside and alpha-D-glucopyranoside, respectively.


A glucotriose consisting of two alpha-D-glucose residues and a beta-D-glucose at the reducing end joined in sequence  by (1->4) glycosidic linkages.


A glucotriose that is beta-D-glucopyranose in which the hydroxy groups at positions 4 and 6 have been converted into the corresponding alpha-D-glucopyranosyl and beta-D-glucopyranosyl derivatives, respectively.


A glucotriose consisting of three molecules of beta-D-glucopyranose attached in sequence by (1->6) and (1->3) glycosidic linkages.


A glucotriose that is beta-D-glucopyranose in which the hydroxy groups at positions 2 and 6 have been converted into D-glucopyranosyl derivatives.


A glucotriose consisting of D-glucopyranose, alpha-D-glucopyranose and beta-D-glucopyranose residues joined in sequence by two (1->4) glycosidic bonds. The configuration of the anomeric centre at the non-reducing terminus is not specified.


A glucotriose consisting of three beta-D-gluopyranose residues joined in sequence by (1->3) and (1->4) glycosidic bonds.


A glucotriose that is beta-D-glucopyranose in which the hydroxy groups at positions 2 and 3 have each been converted into the corresponding beta-D-glucopyranoside.


A glucotriose consisting of alpha-D-glucopyranose, beta-D-glucopyranose and D-glucopyranose residues joined in sequence by (1->2) glycosidic bonds.


A glucotriose that is beta-D-glucose in which the hydroxy groups at positions 2 and 4 have each been converted to the corresponding beta-D-glucoside.


A glucotriose consisting of three beta-D-glucopyranose residues joined in sequence by (1->3) and (1->6) glycosidic bonds.


A glucotriose consisting of one beta-D-glucopyranose and two alpha-D-glucopyranose residues joined in sequence by (1->2) and (1->3) glycosidic linkages.


A trisaccharide consisting of three alpha-D-glucose units connected via (1->3) linkages. Also known as alpha-nigerotriose.


A glucotriose that is D-glucopyranose in which the hydroxy groups at positions 2 and 6 have each been converted into the corresponding beta-D-glucopyranosyl derivatives.


A glucotriose consisting of three molecules of beta-D-glucopyranose attached in sequence by (1->2) and (1->6) glycosidic linkages.


A glucotriose consisting of beta-D-glucopyranose, alpha-D-glucopyranose and D-glucopyranose residues joined in sequence by (1->6) and (1->4) glycosidic bonds.


cellotriose

A glucotriose consisting of three


An alpha-D-Glcp-(1->3)-[alpha-D-Glcp-(1->4)]-D-Glcp in which the carbon bearing the anomeric hydroxy group has alpha- configuration.


A glucotriose consisting of two alpha-D-glucopyranose residues and a D-glucopyranose residue joined in sequence by (1->4) and (1->6) glycosidic bonds.


A glucotriose that is D-glucopyranose in which the hydroxy groups at positions 3 and 4 have each been converted to the corresponding alpha-D-glucopyranosyl derivative.


selaginose

A glycosyl glycoside derivative that is alpha-D-glucopyranosyl-(1->2)-alpha-D-glucopyranose in which the anomeric hydroxy group has been glycosylated by an alpha-D-glucopyranosyl group.


A alpha-D-Glcp-(1->4)-[alpha-D-Glcp-(1->6)]-D-Glcp which has alpha- configuration at the anomeric carbon of the non-terminal glucopyranose ring.


A glucotriose that is D-glucopyranose in which the hydroxy groups at positions 2 and 4 have been converted into the corresponding beta-D-glucopyranosyl and alpha-D-glucopyranosyl derivatives, respectively.


A glucotriose consisting of three alpha-D-glucopyranose residues joined in sequence by (1->6) and (1->2) glycosidic bonds.


beta-cellotriose

A cellotriose with a beta-configuration at the anomeric position.


A glucotriose consisting of two beta-D-glucopyranose residues and a D-glucopyranose residue joined in sequence by (1->6) and (1->3) glycosidic bonds.


A glucotriose consisting of two beta-D-glucopyranosyl residues and a D-glucopyranosyl residue joined in sequence by (1->4) and (1->3) glycosidic bonds.


A glucotriose consisting of alpha-D-glucopyranose, beta-D-glucopyranose and D-glucopyranose residues joined in sequence by (1->6) and (1->2) glycosidic bonds.


A glucotriose consisting of an alpha-D-glucopyranose residue and two beta-D-glucopyranose residues joined in sequence by (1->4) and (1->6) glycosidic bonds.


A glucotriose consisting of two alpha-D-glucopyranosyl residues and a D-glucopyranosyl residue joined in sequence by (1->3) and (1->2) glycosidic linkages.


alpha-cellotriose

A cellotriose with a alpha-configuration at the anomeric position.


A glucotriose composed of alpha-D-glucopyranose, alpha-D-glucopyranose and beta-D-glucofuranose residues joined in sequence by 1->6 glycosidic linkages.


Grade 2 Proteinuria, CTCAE

description: Adult: 2+ and 3+ proteinuria; urinary protein 1.0-<3.5 g/24 hrs; Pediatric: Urine P/C (Protein/Creatinine) ratio 0.5-1.9


Grade 3 Proteinuria, CTCAE

description: Adult: Urinary protein >=3.5 g/24 hrs; 4+ proteinuria; Pediatric: Urine P/C (Protein/Creatinine) ratio >1.9


Grade 1 Proteinuria, CTCAE

description: 1+ proteinuria; urinary protein > or = to ULN-<1.0 g/24 hrs


name: Distal Bile Duct Cancer pNX TNM Finding v7

description: Distal bile duct cancer in which the regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


18-hydroxylinoleic acid

An omega-hydroxy fatty acid that is linoleic acid in which one of the terminal methyl hydrogens has been replaced by a hydroxy group.


name: Uterine Corpus Spindle Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic spindle cells.


lipid A 4'-(2-aminoethyl diphosphate)

A member of the class of lipid As in which the 4' phosphate group of lipid A is replaced by 2-aminoethyl diphosphate.


description: A rare serous cystadenocarcinoma that arises from the paratesticular structures.


D-threonine

An optically active form of threonine having D-configuration.


L-threonine

An optically active form of threonine having L-configuration.


name: Fumarate Hydratase-Deficient Renal Cell Carcinoma

description: A rare, highly aggressive renal cell carcinoma caused by germline or (in a subset) somatic mutation of fumarate hydratase gene. It arises mostly in the setting of hereditary leiomyomatosis-renal cell carcinoma syndrome.


name: Prostate Cancer Pathologic Regional Lymph Nodes TNM Finding v6

description: A pathologic finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of regional lymph nodes. TNM pathologic regional lymph nodes findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


name: Prostate Cancer pNX TNM Finding v6 and v7

description: Prostate cancer in which the regional lymph nodes were not sampled. (from AJCC 6th and 7th Eds.)


name: Prostate Cancer pN1 TNM Finding v6 and v7

description: Prostate cancer with metastases in regional node(s).  (from AJCC 6th and 7th Eds.)


name: Prostate Cancer pN0 TNM Finding v6 and v7

description: Prostate cancer with no positive regional nodes. (from AJCC 6th and 7th Eds.)


Grade 3 Encephalitis Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities


Acephalostomia

description: A congenital defect characterized by the absence of most or all of the head, with the presence of a mouth-like opening on the upper thorax.


6-tuliposide B

A 6-O-acyl-D-glucose in which the 6-acyl group is specified as (3S)-3,4-dihydroxy-2-methylidenebutanoyl. A secondary metabolite with potent antibacterial activity, occurring specifically in tulip anthers.


Grade 1 Colonic Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Hemorrhoidal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


An amido thiophene-2-carboxylic acid derivative used as an inhibitor of HCV (Hepatitis C Virus) RNA polymerase.


Myositis, Proliferative

description: A rapidly growing, poorly circumscribed, mass-forming proliferation that arises from the skeletal muscle. It is characterized by the presence of spindle-shaped fibroblasts, round ganglion-like cells, myxoid to collagenous stroma formation, and high mitotic activity. It recurs only rarely following local excision and does not metastasize.


Vascular Access Complication, CTCAE

description: A finding of a previously undocumented problem related to the vascular access site.


name: Grade 1 Vascular Access Complication, CTCAE

description: TPA administration into line with no intent for systemic therapy indicated


name: Grade 3 Vascular Access Complication, CTCAE

description: Pulmonary embolism, deep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure)


name: Grade 2 Vascular Access Complication, CTCAE

description: Device dislodgement, blockage, leak, or malposition; device replacement indicated


name: Grade 5 Vascular Access Complication, CTCAE

description: Death


name: Grade 4 Vascular Access Complication, CTCAE

description: Life-threatening consequences with hemodynamic or neurologic instability


Orbital Sarcoma pT4 TNM Finding v8

description: Orbital sarcoma with tumor of any size with invasion of globe or periorbital structures, including eyelid, conjunctiva, temporal fossa, nasal cavity, paranasal sinuses, and/or central nervous system. (from AJCC 8th Ed.)


diphenyleneiodonium chloride

An organic chloride salt having dibenziodolium as the counterion.


An 8-heptadecenal in which the double bond at position 8 adopts a cis-configuration.


A monounsaturated fatty aldehyde that is heptadecanal carrying a double bond at position 8.


An 8-heptadecenal in which the double bond at position 8 adopts a trans-configuration.


name: Grade 4 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


chondrochloren A

A monocarboxylic acid amide with formula C27H40ClNO7, that is produced by Chondromyces crocatus and exhibits antibiotic properties.


An indolylmethylglucosinolate that is the conjugate base of neoglucobrassicin, obtained by deprotonation of the sulfo group.


An alkenylglucosinolate that is the conjugate base of gluconapin.


A thia-alkylglucosinolate resulting from the removal of the proton of the hydrogen sulfate group of any omega-[(methylsulfanyl)alkyl]glucosinolic acid.


An alkylglucosinolate that is the conjugate base of glucocapparin.


An indolylmethylglucosinolate that is the conjugate base of 4-hydroxyglucobrassicin.


An alkylglucosinolate that is the conjugate base of 2-methylbutylglucosinolic acid.


A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.


A hydroxy-alkylglucosinolate that is 2-methylbutylglucosinolate which has been hydroxylated at the 2-position of the 2-methylbutyl chain.


glucosinolate

Water-soluble anionic substituted thioglucosides. Glucosinolates have a central C atom which is bonded via an S atom to a glycone group and via an N atom to a sulfonated oxime group, and which also carries a side-group. The side-chain and sulfate group have an anti stereochemical configuration across the C=N double bond.


aralkylglucosinolate

A glucosinolate having a aralkyl side chain.


A glucosinolate resulting from the removal of the proton from the oxime hydrogen sulfate group of glucoraphenin.


alkenylglucosinolate

A glucosinolate that is the conjugate base of alkenylglucosinolic acid.


An alkenylglucosinolate that is the conjugate base of sinigrin.


pentylglucosinolate

An alkylglucosinolate that is the conjugate base of pentylglucosinolic acid.


thia-alkylglucosinolate

A glucosinolate in which the side-chain consists of a thia-alkyl group.


A thia-alkylglucosinolate that has a 5-(methylsulfanyl)pentyl side chain attached to the sulfonated oxime group.


butylglucosinolate

An alkylglucosinolate that is the conjugate base of butylglucosinolic acid.


hydroxy-alkylglucosinolate

A glucosinolate in which the side-chain consists of a hydroxylated alkyl group.


An indolylmethylglucosinolate that is the conjugate base of 4-methoxyglucobrassicin, obtained by deprotonation of the sulfo group.


An hydroxy-alkylglucosinolate that is isobutylglucosinolate which has been hydroxylated at the 2-position of the isobutyl chain.


A glucosinolate that is glucobrassicanapin which has been hydroxylated at the 3-position of the hex-5-enimidoyl chain.


A indolylmethylglucosinolate that is the conjugate base of sulfoglucobrassicin.


isobutylglucosinolate

An alkylglucosinolate that is the conjugate base of isobutylglucosinolic acid.


An aralkylglucosinolate that is glucotropeolin in which the phenyl group is substituted at position 3 by a methoxy group.


A xi-progoitrin(1-) that is the conjugate base of epi-progoitrin.


hydroxy-alkenylglucosinolate

A glucosinolate in which the side-chain consists of a hydroxylated alkenyl group.


An indolylmethylglucosinolate that is the conjugate base of glucobrassicin, obtained by deprotonation of the sulfo group.


A aralkylglucosinolate that is the conjugate base of gluconasturtiin.


sulfonate

The sulfur oxoanion formed by deprotonation of sulfonic acid.


A glucosinolate resulting from the removal of a proton from the oxime hydrogen sulfate moiety of xi-progoitrin.


An alkylglucosinolate that is the conjugate base of glucocochlearin.


An alkenylglucosinolate that is the conjugate base of glucobrassicanapin.


A thia-alkylglucosinolate resulting from the removal of the proton of the hydrogen sulfate group of glucoiberverin.


A xi-progoitrin(1-) that is the conjugate base of progoitrin.


propylglucosinolate

An alkylglucosinolate that is the conjugate base of propylglucosinolic acid.


glycosinolate

An sulfur oxoanion resulting from the deprotonation of the hydroxy group attached to the sulfur of a glycosinolic acid.


A glucosinolate that is the  conjugate base of glucoraphanin.


An alkylglucosinolate resulting from the removal of the proton of the hydrogen sulfate group of any omega-[(methylsulfinyl)alkyl]glucosinolic acid.


A thia-alkylglucosinolate that has a 4-(methylsulfanyl)butyl side chain attached to the sulfonated oxime group.


A alkylglucosinolate that is the conjugate base of glucoputranjivin.


indolylmethylglucosinolate

A glucosinolate that is the conjugate base of indolylmethylglucosinolic acid.


name: Conjunctival Carcinoma cM1 TNM Finding v8

description: Conjunctival carcinoma with distant metastasis. (from AJCC 8th Ed.)


Pancreatic Beta Cell Adenoma

description: An adenoma arising from the beta cells of the pancreas.  It produces insulin.


A dinitrotoluene that is toluene in which the hydrogens at positions 2 and 3 have been replaced by nitro groups.


Stable Disease by Computed Tomography

description: The size and extent of tissue involvement by cancer is neither decreasing nor increasing, based on CT scan and criteria-defined assessments.


Stable Disease

description: A disease that is neither decreasing nor increasing in extent or severity.


Stable cGVHD

description: No change in chronic Graft versus Host Disease (cGVHD) progression during the preceding 3 months.


name: Modified Overall Immune Related Response Criterion, Stable Disease

description: The evaluation of the antitumor response shows that the sum of the longest diameters of target and new measurable lesions do not meet the criteria for complete remission, partial response (compared to baseline) or progressive disease (compared to nadir).


Stable Metabolic Disease

description: The absence of change or mild changes of metabolic tumor activity in all relevant lesions based on a pre-defined threshold.


Carcinoma of lower gum

description: A carcinoma of the oral cavity that arises from the lower gingiva.


Carcinoma of upper gum

description: A carcinoma of the oral cavity that arises from the upper gingiva.


Gingival Spindle Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma that arises from the gingiva. It is characterized by the presence of malignant pleomorphic spindle cells.


Gingival Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the gingival mucosa. It presents as an ulcerated lesion or exophytic mass. The prognosis is usually poor.


Gingival Angiofibroma

description: A benign neoplasm arising from the fibrous soft tissues of the gingiva. It is characterized by the presence of spindle-shaped fibroblasts and numerous dilated vascular channels.


squamous cell carcinoma of lower gum

description: A squamous cell carcinoma of the oral cavity that arises from the lower gingiva.


carcinoma of gingiva

description: A carcinoma of the oral cavity that arises from the upper or lower gingiva.


squamous cell carcinoma of upper gum

description: A squamous cell carcinoma of the oral cavity that arises from the upper gingiva.


name: Retromolar Trigone Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the retromolar trigone. Pain, often radiating to the ear, is the presenting symptom. The prognosis is poor.


9'-hydroxyabscisic acid

An  oxo monocarboxylic acid that is (+)-abscisic acid substituted by a hydroxy group at position 9'.


name: Paranasal sinus teratocarcinosarcoma (type)

description: A malignant sinonasal neoplasm with combined histological features of teratoma and carcinosarcoma, lacking malignant germ cell components. (WHO 2017)


carcinosarcoma of salivary gland

description: An aggressive, high grade malignant tumor that arises from the salivary gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Lacrimal Gland Carcinosarcoma

description: An aggressive, high grade malignant neoplasm that arises from the lacrimal gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Pleomorphic adenoma of parotid gland

description: A benign, slow-growing tumor that arises from the parotid gland.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin and women are more often affected than men.


name: Recurrent Childhood Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma in childhood after a period of remission.


name: Malignant Mixed Tumor of the Major Salivary Gland

description: A malignant tumor arising from the parotid gland, submandibular gland, or sublingual gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Conjunctival Adenosquamous Carcinoma

description: A carcinoma that arises from the conjunctiva. It is characterized by the presence of a variable combination of squamous (epidermoid) cells and mucous cells, arranged in invasive sheets, cords, and ducts. (WHO 2018)


name: Stage III Uterine Corpus Adenosarcoma AJCC v8

description: Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Adenocarcinoma with cartilaginous and osseous metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive cartilage and/or bone formation.


Recurrent Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma after a period of remission.


Uterine Carcinosarcoma, Homologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements that arise from the tissues of the uterus.


name: Uterine Corpus Adenosarcoma by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus adenosarcoma according to the American Joint Committee on Cancer, 8th edition.


name: Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component.


name: Metastatic Endometrial Adenosquamous Carcinoma

description: Endometrial adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: mixed acinar-endocrine carcinoma of pancreas

description: A carcinoma that arises from the pancreas and is composed of acinar carcinoma and neuroendocrine carcinoma components in both the primary tumor and the metastatic sites.


name: Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm

description: A neoplasm that arises from the cervix and is characterized by the presence of benign epithelial and benign mesenchymal elements. This category includes adenofibroma and adenomyoma.


Primary peritoneal carcinosarcoma

description: An extremely rare and highly aggressive malignant neoplasm arising from the peritoneum.  Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.


Hybrid Salivary Gland Tumor

description: A rare neoplasm that arises from the salivary gland and consists of at least two histologically distinct types of tumor within the same topographic location. The tumor components can be either benign or malignant.


name: Uterine Carcinosarcoma, Heterologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements composed of tissues that are not found in the uterus (e.g., bone, cartilage, skeletal muscle).


name: Appendix Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the appendix.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Metastasizing Pleomorphic Adenoma of the Salivary Gland

description: A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features.  The most common sites of metastasis are bone, lung, and head and neck.


Oropharyngeal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the oropharynx.


name: Stage IIIA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Borderline Serous Cystadenofibroma

description: A neoplasm of low malignant potential arising from a site in the female reproductive system. Almost all cases have been reported in the ovary. It is characterized by the presence of cystic spaces which are lined by atypical serous epithelial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion.


Advanced Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIC Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Advanced Malignant Mixed Mesodermal (Mullerian) Tumor

description: A malignant mixed mesodermal (Mullerian) tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage I Uterine Corpus Adenosarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Metastatic Cervical Adenosquamous Carcinoma

description: A cervical adenosquamous carcinoma that has spread to another anatomic site.


name: Testicular Mixed Choriocarcinoma and Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Metastatic Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Squamous Cell Carcinoma with Sarcomatoid Differentiation

description: A rare carcinoma of the skin characterized by the presence of squamous cell carcinomatous and sarcomatous components.


Sellar Mixed Germ Cell Tumor

description: A mixed germ cell tumor that arises from or adjacent to the sellar region.


Cellular Pleomorphic Adenoma

description: A pleomorphic adenoma with increased cellularity.


name: Metastatic Vaginal Adenosquamous Carcinoma

description: Vaginal adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Anal Canal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the anal canal.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Recurrent Childhood Oligoastrocytoma

description: The reemergence of oligoastrocytoma in childhood after a period of remission.


Hard Palate Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the hard palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


carcinosarcoma of gallbladder

description: A carcinoma that arises from the gallbladder and it is characterized by the presence of a sarcomatous component.  The sarcomatous component may contain osteosarcoma, chondrosarcoma, or rhabdomyosarcoma elements.


name: Mixed neuroendocrine-non neuroendocrine neoplasm

description: A rare neoplasm that consists of neuroendocrine and non-neuroendocrine cellular components. At least 30% of either component should be present for the diagnosis to be made.


name: Metastatic Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread from its original site of growth to another anatomic site.


name: Pancreatic Mixed Ductal Adenocarcinoma-Neuroendocrine Tumor

description: A very rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine tumor component.


name: Testicular Mixed Embryonal Carcinoma and Teratoma

description: A malignant mixed germ cell tumor arising from the testis, characterized by the presence of an embryonal carcinomatous component and a teratomatous component.


name: Gallbladder Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the gallbladder and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Sinonasal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the sinonasal tract.


Metastatic Carcinosarcoma

description: Carcinosarcoma that has spread from its original site of growth to another anatomic site.


Recurrent Fallopian Tube Carcinosarcoma

description: The reemergence of fallopian tube carcinosarcoma after a period of remission.


Hybrid Salivary Gland Carcinoma

description: A rare carcinoma that arises from the salivary gland and consists of at least two histologically distinct types of carcinoma within the same topographic location. The carcinoma components usually are adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, and/or salivary duct carcinoma. Adenoid cystic carcinoma is commonly the predominant component.


Adult Mixed Glioma

description: A mixed glioma that occurs during adulthood.


Malignant chondroid syringoma

description: A rare malignant skin neoplasm that arises from a benign mixed tumor of the skin (chondroid syringoma).


Uterine Ligament Adenomyoma

description: A benign neoplasm that arises from the broad or other uterine ligaments. It is characterized by the presence of a glandular and a mesenchymal component.


name: Testicular Mixed Choriocarcinoma and Embryonal Carcinoma

description: A malignant mixed germ cell tumor that arises from the testis and is characterized by the presence of choriocarcinoma and embryonal carcinoma morphologic components.


name: Stage IIIB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Mixed parotid tumor

description: A benign or malignant neoplasm that arises from the parotid gland.  It is characterized by the presence of epithelial and mesenchymal elements.  This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma.


name: Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal-Type

description: A very rare testicular germ cell tumor that combines teratoma and yolk sac tumor. It usually affects young children. It is not associated with chromosome 12p amplification or germ cell neoplasia in situ.


Childhood Oligoastrocytoma

description: An oligoastrocytoma that occurs during childhood.


name: Gastric Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the stomach and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma

description: A carcinoma that arises from a pleomorphic adenoma in the minor salivary glands.  Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months.  Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis.  In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Oral Cavity Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the salivary glands in the oral cavity.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


name: Stage IA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus adenosarcoma with tumor limited to the endometrium/endocervix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and yolk sac tumor morphologic elements.  Patients may present with painless or painful testicular swelling.


Recurrent Oligoastrocytoma

description: The reemergence of oligoastrocytoma after a period of remission.


name: Pancreatic Mixed Ductal-Neuroendocrine Neoplasm

description: A rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine neoplastic component. The latter is usually a poorly differentiated neuroendocrine carcinoma and rarely a well differentiated neuroendocrine tumor.


name: Testicular Mixed Yolk Sac Tumor and Teratoma

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac and teratomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Malignant Submandibular Gland Mixed Tumor

description: A malignant tumor arising from the submandibular gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


name: Benign Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm

description: A non-metastasizing neoplasm that arises from the uterine corpus and is composed of epithelial and mesenchymal elements. Representative examples include adenomyoma and adenofibroma.


name: Testicular Mixed Yolk Sac Tumor and Teratoma with Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac, teratomatous, and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Mixed Carcinoma

description: A carcinoma characterized by the presence of more than one malignant epithelial histologic pattern.


name: Stage IVB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Recurrent Cervical Adenosquamous Carcinoma

description: The reemergence of cervical adenosquamous carcinoma after a period of remission.


name: Stage IB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Uterine corpus adenosarcoma with tumor invading to less than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Primary Peritoneal Carcinosarcoma

description: The reemergence of primary peritoneal carcinosarcoma after a period of remission.


name: Malignant Mixed Tumor, Not Otherwise Specified

description: A malignant myoepithelioma characterized by the presence of a minor ductal component.


Childhood Anaplastic Oligoastrocytoma

description: An anaplastic oligoastrocytoma that occurs during childhood.


Childhood Breast Fibroadenoma

description: A fibroadenoma that arises from the breast and occurs during childhood.


name: Ampulla of Vater Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the ampulla of Vater and the periampullary region. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Childhood Mixed Glioma

description: A mixed glioma that occurs during childhood.


name: Stage II Uterine Corpus Adenosarcoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


adenosquamous carcinoma of tongue

description: A rare adenosquamous carcinoma that arises from the tongue.


name: Testicular Mixed Embryonal Carcinoma and Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma and a seminomatous component.


name: Refractory Uterine Corpus Carcinosarcoma

description: Uterine Corpus Carcinosarcoma that is resistant to treatment.


Advanced Carcinosarcoma

description: Carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Choriocarcinoma combined with other germ cell elements

description: A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous component admixed with another germ cell component (e.g. embryonal carcinoma, teratoma, or seminoma).


name: Recurrent Endometrial Adenosquamous Carcinoma

description: The reemergence of endometrial adenosquamous carcinoma after a period of remission.


name: Malignant Vaginal Mixed Tumor Resembling Synovial Sarcoma

description: A very rare malignant mixed epithelial and mesenchymal neoplasm that arises from the vagina and resembles synovial sarcoma.  It is characterized by a biphasic pattern and is composed of gland-like structures that are lined by epithelial cells and a cellular mesenchymal component.


Malignant Parotid Gland Mixed Tumor

description: A malignant tumor arising from the parotid gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Odontogenic Carcinosarcoma

description: An extremely rare malignant mixed odontogenic neoplasm in which both the epithelial and the mesenchymal components are cytologically malignant. (WHO 2017)


name: Advanced Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Invasive Bladder Mixed Carcinoma

description: An invasive bladder carcinoma characterized by the presence of more than one histologic pattern.


name: Human Papillomavirus-Related Adenosquamous Carcinoma

description: An adenosquamous carcinoma associated with the presence of human papillomavirus infection.


name: Esophageal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the esophagus and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Vaginal Adenosquamous Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of malignant glandular and malignant squamous epithelial components.


Laryngeal Pleomorphic Adenoma

description: A very rare pleomorphic adenoma that arises from the larynx.


name: Stage IVA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Mixed Tumor, Not Otherwise Specified

description: A benign myoepithelioma characterized by the presence of a minor ductal component.


name: Vulvar Composite Hidradenoma Papilliferum and Fibroadenoma

description: A benign composite neoplasm that arises from the vulva and is characterized by mixed histopathologic features of hidradenoma papilliferum and fibroadenoma.


name: Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of embryonal carcinoma and yolk sac morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Pancreatic Mixed Acinar-Ductal Neuroendocrine Carcinoma

description: A very rare carcinoma that arises from the pancreas and is composed of ductal adenocarcinoma, acinar carcinoma, and neuroendocrine carcinoma components.


Trichoblastic carcinosarcoma

description: A rare biphasic follicular neoplasm consisting of a malignant epithelial component resembling follicular germinative cells closely associated with a malignant stromal component differentiating towards specific follicular mesenchyme. (WHO 2018)


name: Metastatic Digestive System Mixed Adenoneuroendocrine Carcinoma

description: Mixed adenoneuroendocrine carcinoma that arises from the digestive system and has metastasized to other anatomic sites.


Hybrid nerve sheath tumor

description: A benign nerve sheath tumor characterized by the combination of histologic features seen in schwannomas, neurofibromas, and perineuriomas.


Pleomorphic adenoma of lacrimal gland

description: A benign, usually encapsulated neoplasm of the lacrimal gland composed of epithelial and mesenchymal cells.  Pleomorphic adenomas are neoplasms that develop in the salivary glands or heterotopic salivary gland tissues.  It has been suggested that myoepithelial cells play a major role in the histogenesis of these tumors.  In the lacrimal gland, pleomorphic adenomas presumably develop from metaplastic myoepithelial cells.


name: Malignant Mixed Tumor of the Minor Salivary Gland

description: A malignant tumor arising from the minor salivary glands.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


name: Seminal Vesicle Mixed Epithelial and Stromal Tumor

description: A rare biphasic neoplasm that arises from the seminal vesicle. It is characterized by the presence of stromal and benign epithelial components. Rarely, the stromal component may display atypia and mitotic activity and the tumor may behave in a malignant clinical course.


Soft Palate Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the soft palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


Breast Pleomorphic Adenoma

description: A rare, benign and well circumscribed neoplasm that arises from the breast.  It is characterized by the proliferation of epithelial and myoepithelial cells surrounded by chondroid stroma.


name: Stage IC Uterine Corpus Adenosarcoma AJCC v8

description: Stage IC includes: T1c, N0, M0. T1c: Uterine corpus adenosarcoma with tumor invading more than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IV Uterine Corpus Adenosarcoma AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Metastatic Malignant Mixed Mesodermal (Mullerian) Tumor

description: A malignant mixed mesodermal (Mullerian) tumor that has spread from its original site of growth to another anatomic site.


Recurrent Uterine Corpus Carcinosarcoma

description: The reemergence of uterine corpus carcinosarcoma after a period of remission.


Parotid Gland Carcinosarcoma

description: An aggressive, high grade malignant tumor that arises from the parotid gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


distigmine

A carbamate ester resulting from the formal condensation of both carboxy groups of hexane-1,6-diylbis(methylcarbamic acid) with the hydroxy group of 3-hydroxy-1-methylpyridinium.


name: Gallbladder Mucinous Cystic Neoplasm, High Grade

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of severe atypia.


Progressive Metabolic Disease

description: An increase of metabolic tumor activity in all relevant lesions, based on pre-defined thresholds, or the development of new lesions.


name: Adenocarcinoma of anogenital mammary-like glands

description: A primary invasive malignant epithelial neoplasm of the vulva showing morphological features of recognized breast adenocarcinomas. (WHO, 2014)


Vulvar Adenocarcinoma, Intestinal-Type

description: A rare vulvar mucinous adenocarcinoma that resembles a large intestinal adenocarcinoma.


name: 4-(dimethylamino)benzoic acid [2-(2-methoxyphenyl)-2-oxoethyl] ester


curacozole

An azamacrocycle obtained from a core peptide of sequence Phe-Ile-Ile-Gly-Ser-Thr-Cys-Cys encoded in the genome of several Streptomyces species. It exhibits potent cytotoxic activity against HCT116 and HOS cancer cells.


A chlorocatechol that is catechol which is substituted by a methyl group at position 3 and a chlorine at position 4.


name: 2-(5-methyl-3-oxo-1H-pyrazol-2-yl)-6-oxo-1H-pyrimidine-5-carboxylic acid ethyl ester


name: Grade 2 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Left Ventricular Diastolic Dysfunction, CTCAE


name: 3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester


pseudopelletierine

An azabicycloalkane alkaloid that is 9-azabicyclo[3.3.1]nonane substituted by a methyl group at position 9 and an oxo group at position 3. It is found in pomegranate trees.


biotinylated alpha-gal

Biotin linked to the alpha-gal epitope through a 6-amino-N-(3-hydroxypropyl)hexanamide spacer.


name: (2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester


A member of the class of azabicycloalkanes that is 1,3-diazabicyclo[2.2.0]hex-4-en-2-one substituted at position 6 by a 5-amino-5-methyl-2,4-dioxodihydropyrimidin-6-yl group.


A disaccharide derivative in which alpha-D-galactosaminyl-(1->4)-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


An N-glycosyl compound that is a metabolite produced by the bacterium Mycoplasma genitalium.


name: 3-hydroxy-2-phenylpropanoic acid [(1R,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester


A tetrasaccharide derivative in which N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


A disaccharide derivative in which N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


A member of the class of azabicycloalkanes that is 1-azabicyclo[3.2.0]heptan-7-one substituted at positions 3 and 6 by (2-aminoethyl)thio and ethyl groups respectively.


(R)-atropine

An atropine with a 2R-configuration.


name: 2-hydroxy-2-phenylacetic acid [(5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester


biotin sulfone

A member of the class of biotins that is biotin sulfoxide with a sulfone group replacing the sulfoxide.


ecgonone methyl ester

The methyl ester of (1R,2R,5S)-8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylic acid (ecgonone).


biotin amide

A monocarboxylic acid amide derived from  biotin.


biocytin

A  monocarboxylic acid amide that results from the formal condensation of the carboxylic acid group of biotin with the N(6)-amino group of L-lysine.


saxagliptin

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.


name: (2S)-3-hydroxy-2-phenylpropanoic acid [(5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester


A member of the class of azabicycloalkanes that is 1,3-diazabicyclo[2.2.0]hex-4-en-2-one substituted at position 6 by a 5,6-diamino-2-oxo-2,3,4,5-tetrahydropyrimidin-4-yl group.


durlobactam

A member of the class of azabicycloalkanes that is (1R,2S,5R)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-ene-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group.


name: (1R,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid methyl ester


name: 3-hydroxy-2-phenylpropanoic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester


tedisamil

A member of the class of diazabicyclononanes that is (1s,5s)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane] in which the hydrogens at positions 3 and 7 are replaced by cyclopropylmethyl groups. It is a potassium channel blocker and an antiarrhythmic agent currently currently in development for the treatment of atrial fibrillation.


A tetrasaccharide derivative in which alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


name: 3-hydroxy-2-phenylpropanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester


A hexasaccharide derivative in which alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


name: 2-hydroxy-2-phenylacetic acid [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester


biotins

Compounds containing a biotin (5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid) skeleton.


biotin sulfoxide

A sulfoxide that is the S-oxide of biotin.


hapten GNL

An azabicycloalkane that consists of ecgonine having phenylphosphonyl and alkyl groups attached to the hydroxy and carboxy groups respectively. Used as a transition state analogue of cocaine.


A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.


O-benzoylecgonine 5-carboxypentyl ester

An azabicycloalkane that consists of ecgonine having benzoyl and 5-carboxypentyl groups attached to the hydroxy and carboxy functions respectively.


hyoscyamine

An atropine with a 2S-configuration.


BICOZAMYCIN

A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.


An N-glycosyl compound that is a metabolite produced by the bacterium Mycoplasma genitalium.


An azabicycloalkane that consists of a hexahydropyrimidine ring fused with a cyclopentane ring at positions 2 and 3.


A pentasaccharide derivative in which alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


name: O-hydroxy(phenyl)phosphinoyl ecgonine methyl ester

description: The O-hydroxy(phenyl)phosphinoyl derivative of ecgonine methyl ester.


A member of the class of azabicycloalkanes that is 1-azabicyclo[3.2.0]heptan-7-one substituted at position 3 by a (2-aminoethyl)thio group.


ioflupane

An azabicycloalkane that is ecgonine methyl ester in which the N-methyl group is replaced by 3-fluoropropyl and the 3beta-hydroxy group is replaced by 4-((123)I)iodophenyl. Used for the imaging of dopamine transporters in the brain of adult patients with potential Parkinsonian Syndromes.


tropine

A derivative of tropane having a hydroxy group at the 3-position.


avibactam

A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.


TROPANSERIN

A tropane alkaloid that consists of tropine in which the hydrogen of the hydroxy function is substituted by a 3,5-dimethylbenzoyl group.


A trisaccharide derivative in which alpha-D-galactosaminyl-(1->4)-alpha-D-galactosaminyl-(1->4)-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


A trisaccharide derivative in which N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosamine is linked glycosidically to biotin via a (21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-1-yl)amino spacer. One of a set of synthesised biotinylated oligo-alpha-(1->4)-D-galactosamines comprising from two to six monosaccharide units, along with their N-acetylated derivatives (PMID:31913631), aimed at analysing the specificity of the antibody responses to a complex exopolysaccharide galactosaminogalactan found in Aspergillus fumigatus, the most important airborne human fungal pathogen in industrialized countries.


intermedine

A carboxylic ester compound formed from condensation between retronecine and (2S,3R)-2,3-dihydroxy-2-isopropylbutanoic acid.