name: Atherosclerosis of Unspecified Type of Bypass Graft(s) of the Left Leg with Ulceration of Calf

description: Evidence of atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of calf.


name: Other specified pulmonary heart diseases

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Evidence of other specified pulmonary heart diseases not specified elsewhere.


name: Grade 3 Other Pulmonary and Upper Respiratory, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Grade 2 Platelets, CTCAE

description: <75,000 - 50,000/mm(3); <75.0 - 50.0 x 10e9 /L


Glossopharyngeal Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the glossopharyngeal nerve (ninth cranial nerve).


name: Arthropathy following Intestinal Bypass, Unspecified Shoulder

description: Evidence of arthropathy following intestinal bypass in an unspecified shoulder.


Breast Columnar Cell Lesion

description: A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma.  These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units.  Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ.  Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known.


name: Flaccid Hemiplegia Affecting Right Non-Dominant Side

description: Evidence of flaccid hemiplegia affecting the right non-dominant side.


Lymphoma, Mixed-Cell

description: An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes.


name: Lugano Classification Stage III Adult Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Pre-Gestational Diabetes

description: Diabetes diagnosed before current pregnancy. (reVITALize)


name: Grade 5 Other Blood and Bone Marrow, CTCAE


name: Alcohol Dependence with Other Alcohol-Induced Disorder

description: Evidence of alcohol dependence with other alcohol-induced disorder.


Type II Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


name: MLH1 Gene Promoter Hypermethylation Negative

description: A genetic finding indicating the absence of DNA hypermethylation in the promoter region of the MGMT gene.


Adenovirus DNA Viremia

description: A laboratory test result indicating the presence of adenovirus DNA in the blood.


Hepatic Failure, Unspecified with Coma

description: Evidence of hepatic failure, unspecified with coma.


name: Grade 2 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Degenerated Schwannoma

description: A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change.


Retinopathy of Prematurity, AE

description: An adverse event characterized by a retinal condition of very immature infants that may be characterized by non-vascularized retinae that may lead to neovascularization, scarring, retinal detachment, and blindness.


name: Pre-Existing Secondary Hypertension Complicating the Puerperium

description: Evidence of pre-existing secondary hypertension complicating the puerperium.


malignant neoplasm of the right orbit

description: Evidence of a malignant neoplasm of the right orbit.


name: Advanced Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 5 Enterocolitis, CTCAE

description: Death


Acute peptic ulcer with hemorrhage

description: Evidence of an acute peptic ulcer, site unspecified, with hemorrhage.


name: Grade 5 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hypothermia, CTCAE

description: <=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation)


name: Grade 2 Hypoxic Ischemic Encephalopathy, AE

description: An adverse event in a newborn characterized by mild transient clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event;  necessitating observation and additional care.


Lymph Gland Infection, CTCAE

description: A disorder characterized by an infectious process involving the lymph nodes.


name: Secondary Malignant Neoplasm of Other and Unspecified of Nervous System

description: Evidence of secondary malignant neoplasm of other and unspecified of nervous system.


name: Unresectable Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that is not amenable to surgical resection.


name: Right Anterior Apical Transition Zone of Prostate

description: The region of the prostate that is located on the anatomical right side of the anterior portion of the apical division of the transition zone.


Factor II Inactivation

description: Presence of inactivating antibodies to prothrombin (factor II) in the blood.


name: Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8

description: Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


Bone Cancer pM1 TNM Finding v7

description: Bone cancer with distant metastasis. (from AJCC 7th Ed.)


name: Grade 1 Small Bowel Obstruction NOS, CTCAE


name: Fetus Small for Gestational Age with Abnormal Doppler

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies.


Grade 3 Urine Output Decreased, CTCAE

description: Adult: Oliguria (<80 ml in 8 hr); Infants: < 0.5 mL/kg per hour for 24 hours; Children: < 500 mL/1.73 m2 body surface area per day


name: Grade 2 Large Intestinal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Grade 2 Hypopituitarism, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Type 2 Diabetes Mellitus with Proliferative Diabetic Retinopathy without Macular Edema, Bilateral

description: Evidence of type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema that is bilateral.


name: Grade 5 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Cranial Nerve VIII Neuropathy, CTCAE


name: Grade 4 Urethra Stricture or Stenosis, CTCAE


name: oligoarticular juvenile idiopathic arthritis of wrist

description: Evidence of pauciarticular juvenile rheumatoid arthritis in an unspecified wrist.


name: Pancreatic Neuroendocrine Tumor Clinical TNM Finding v8

description: A clinical finding about one or more characteristics of a pancreatic neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system.


name: Grade 3 Otitis External Ear Non Infectious, CTCAE


Grade 3 Hepatic Pain, CTCAE

description: Severe pain; limiting self care ADL


Grade 3 Dysesthesia, CTCAE

description: Severe sensory alteration; limiting self care ADL


Anorgasmia, CTCAE

description: A disorder characterized by an inability to achieve orgasm.


Lung Examination Finding

description: A finding noted on auscultation of the lungs.


name: Grade 5 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


B-Cell Markers Negative

description: A finding indicating that expression of B-lymphocyte lineage markers have not been detected in a sample.


name: Metastatic squamous cell carcinoma to skin

description: A squamous cell carcinoma that has spread to the skin from another anatomic site.


name: Peripheral neuropathy due to and following antineoplastic therapy

description: Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


name: Grade 4 Cranial Nerve XI Intra-Operative Injury, CTCAE


name: Grade 5 Gastrointestinal Leak NOS, CTCAE


Bladder Cancer pTX TNM Finding v8

description: Bladder cancer in which the primary tumor cannot be assessed. (from AJCC 8th Ed.)


name: Diabetes Mellitus due to Underlying Condition with Severe Non-Proliferative Diabetic Retinopathy with Macular Edema

description: Evidence of diabetes mellitus due to underlying condition with severe non-proliferative diabetic retinopathy with macular edema.


Depression, CTCAE

description: A disorder characterized by melancholic feelings of grief or unhappiness.


name: Type I Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.


Recurrent Diffuse Midline Glioma

description: The reemergence of diffuse midline glioma after a period of remission.


name: Felty's Syndrome, Unspecified Ankle and Foot

description: Evidence of Felty's syndrome in an unspecified ankle and foot.


Corneal Ulcer, CTCAE

description: A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber.


name: Ovarian Cancer and Primary Peritoneal Carcinoma cM0 TNM Finding v7

description: Ovarian cancer or primary peritoneal carcinoma without evidence of distant metastasis. (from AJCC 7th Ed.)


name: Ocular Adnexal Lymphoma pT1 TNM Finding v8

description: Ocular adnexal lymphoma involving the conjunctiva alone without eyelid or orbital involvement. (from AJCC 8th Ed.)


T0 TNM Finding

description: A primary tumor TNM finding indicating that there is no evidence of primary tumor.


Gallbladder Cancer pTX TNM Finding v7

description: Gallbladder cancer in which the primary tumor cannot be assessed. (from AJCC 7th Ed.)


name: Grade 3 Thorax Soft Tissue Necrosis, CTCAE


name: Malignant Neoplasm of Lower-Inner Quadrant of Unspecified Female Breast

description: Evidence of a malignant neoplasm of the lower-inner quadrant of unspecified female breast.


Childhood Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in children.


name: Hemiplegia following Non-Traumatic Intracerebral Hemorrhage Affecting Unspecified Side

description: Evidence of hemiplegia following non-traumatic intracerebral hemorrhage affecting unspecified side.


Other bipolar disorder

description: Evidence of other bipolar disorder not specified elsewhere.


name: Salivary Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Low Grade Glioma

description: Low grade glioma that has spread from its primary site to another anatomic site.


name: Grade 5 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Ampulla of Vater Cancer Clinical Distant Metastasis TNM Finding v7

description: A clinical finding about one or more characteristics of ampulla of Vater cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.


name: Grade 3 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of soft tissue sarcoma of the abdomen and thoracic visceral organs, following the rules of the TNM AJCC v8 classification system.


Unresectable Diffuse Glioma

description: A diffuse glioma that is not amenable to surgical resection.


name: Grade 3 Non-Myocardial Visceral Arterial Ischemia, CTCAE


name: Substance-Induced Persisting Amnestic Disorder

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the persisting effects of substance use. The memory impairment persists beyond the usual duration of substance intoxication or withdrawal.


name: Pulmonary Artery Intra-Operative Injury, CTCAE


description: Evidence of inhalant abuse with inhalant-induced psychotic disorder with delusions.


name: Grade 3 Cerebral Artery Intra-Operative Injury, CTCAE


name: Appendix Neuroendocrine Tumor cM1a TNM Finding v8

description: Appendix neuroendocrine tumor with metastasis confined to liver. (from AJCC 8th Ed.)


name: Grade 3 Cerebrospinal Fluid Leakage, CTCAE

description: Severe symptoms; medical intervention indicated


name: Carcinoma in Situ of Other Female Genital Organs

description: Evidence of carcinoma in situ of other female genital organs.


Device Revision or Replacement

description: Patient required a corrective invasive procedure in which a device was replaced/revised.


Gallbladder Cancer pT3 TNM Finding v8

description: Gallbladder cancer with tumor perforating the serosa (visceral peritoneum) and/or directly invading the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts. (from AJCC 8th Ed.)


name: Acute Monocytic Leukemia, Unspecified not Having Achieved Remission

description: Evidence of acute monocytic leukemia, not having achieved remission.


Vaginal Cancer pM1 TNM Finding v7

description: Vaginal cancer with distant metastasis.  (from AJCC 7th Ed.)


name: Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Unspecified, Lymph Nodes of Inguinal Region and Lower Limb

description: Evidence of an unspecified mature T-cell and NK-cell non-Hodgkin lymphoma in the lymph nodes of inguinal region and lower limb.


name: Other Classic Hodgkin Lymphoma, Lymph Nodes of Axilla and Upper Limb

description: Evidence of other classic Hodgkin lymphoma in the lymph nodes of axilla and upper limb not specified elsewhere.


Platinum-Resistant Urothelial Carcinoma

description: Urothelial carcinoma that is resistant to platinum therapy.


Liver Lymphangiomatosis

description: Multiple lymphangiomas that affect the liver and other anatomic sites. Although histologically benign, diffuse lymphangiomatosis that affects the liver and multiple organs has a poor prognosis.


name: Supratentorial Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain in which the genetic analysis for fusion genes involving ZFTA or YAP1 genes was unsuccessful or not reported.


Thoracic Nodule

description: A nodular lesion that develops in the chest wall.


Infantile Lesion

description: A benign or malignant lesion that occurs in infancy.


name: Grade 1 Tongue Intra-Operative Injury, CTCAE


name: Skin Squamous Cell Carcinoma or Other Skin Carcinomas pM1 TNM Finding v7

description: Skin squamous cell carcinoma or other skin carcinomas with distant metastases. (from AJCC 7th Ed.)


NTRK Family Gene Alteration Negative

description: An indication that mutation, overexpression, fusion or rearrangement of an NTRK family member gene has not been detected in a sample.


Stage II Merkel Cell Carcinoma AJCC v7

description: Stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0).  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


name: Grade 2 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Malignant Neoplasm of Lower-Inner Quadrant of Unspecified Male Breast

description: Evidence of a malignant neoplasm of the lower-inner quadrant of unspecified male breast.


Pharyngeal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site.


Mixed subtype adenocarcinoma of lung

description: The most frequently seen morphologic variant of lung adenocarcinoma characterized by a mixture of architectural patterns, including acinar, papillary, bronchioloalveolar, and solid pattern.


name: Grade 3 Acute Vascular Leak Syndrome, CTCAE


Vital Exhaustion

description: A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.


Arachnoiditis, CTCAE

description: A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space.


name: Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma Distant Metastasis TNM Finding v8

description: A finding about one or more characteristics of primary cutaneous B-cell/T-cell (non-MF/SS) lymphoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases. (from AJCC 8th Ed.)


name: Microbial IC50 Fold Change from Reference

description: A fold change based on the concentration of a specific drug expected to produce 50 percent inhibition on the enzymatic activity of a microbial organism; it is a ratio calculated by the IC50 Subject Result divided by the IC50 Reference Control Result.


Hemorrhagic cyst

description: A cyst containing blood.


Lung Cancer cM1a TNM Finding v8

description: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural or pericardial nodules or malignant pleural or pericardial effusion. Most pleural (pericardial) effusions with lung cancer are a result of the tumor. In a few patients, however, multiple microscopic examinations of pleural (pericardial) fluid are negative for tumor, and the fluid is nonbloody and not an exudate. If these elements and clinical judgment dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging descriptor. (from AJCC 8th Ed.)


name: Atherosclerosis of Non-Autologous Biological Bypass Graft(s) of the Left Leg with Ulceration of Ankle

description: Evidence of atherosclerosis of non-autologous biological bypass graft(s) of the left leg with ulceration of ankle.


name: Grade 4 Lymphocyte Count Decreased, CTCAE

description: <200/mm3; <0.2 x 10e9/L


name: Urothelial (Transitional Cell) Carcinoma of the Prostate pT3 TNM Finding v7

description: Urothelial (transitional cell) carcinoma of the prostate with tumor invading any of the following: corpus cavernosum, beyond prostatic capsule, bladder neck (extraprostatic extension). (from AJCC 7th Ed.)


name: Recurrent Anal Canal Squamous Cell Carcinoma

description: The reemergence of anal canal squamous cell carcinoma after a period of remission.


name: Grade 2 Other Sexual Reproductive Function, CTCAE


Overlapping malignant neoplasm of brain

description: Evidence of a malignant neoplasm of overlapping sites of the brain.


Peripheral Nerve Infection, CTCAE

description: A disorder characterized by an infectious process involving the peripheral nerves.


Stage IIA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

description: A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


name: Duodenum/Ampulla/Jejunum/Ileum Neuroendocrine Tumor pT1 TNM Finding v7

description: Duodenum/ampulla/jejunum/ileum neuroendocrine tumor invading lamina propria or submucosa and is 1 cm or less in size (small intestinal tumors); for ampullary tumors: tumor 1 cm or less. (from AJCC 7th Ed.)


Cranial Nerve Infection, CTCAE

description: A disorder characterized by an infectious process involving a cranial nerve.


Grade 2 Biliary Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Grade 1 Wheezing, CTCAE

description: Detectable airway noise with minimal symptoms


SHH Negative

description: An indication that SHH expression has not been detected in a sample.


name: Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma pT3 TNM Finding v8

description: Ovarian, fallopian tube, or primary peritoneal carcinoma with tumor involving one or both ovaries or fallopian tubes, or primary peritoneal cancer, with microscopically confirmed peritoneal metastasis outside the pelvis and/or metastasis to the retroperitoneal (pelvic and/or para-aortic) lymph nodes. (from AJCC 8th Ed.)


name: Stage III Extragonadal Non-Seminomatous Germ Cell Tumor


Cutaneous Melanoma pN3c TNM Finding v8

description: Cutaneous melanoma with two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. (from AJCC 8th Ed.)


name: Grade 1 Blood Bicarbonate Decreased, CTCAE

description: <LLN and no intervention initiated


PAS Negative

description: An indication that a sample does not have detectable periodic acid-Schiff staining.


Clinical Complete Response

description: The disappearance of all signs of cancer based on physical exam, such as palpation.


Vaginal Adenoid Basal Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of nests of basaloid cells with focal glandular formations.


name: Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Duodenum and Ampulla of Vater Neuroendocrine Tumor cM1 TNM Finding v8

description: Duodenum and ampulla of Vater neuroendocrine tumor with distant metastasis. (from AJCC 8th Ed.)


Laryngeal Cancer pN2a TNM Finding v8

description: Laryngeal cancer with metastasis in a single ipsilateral or contralateral lymph node, 3 cm or less in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Grade 1 Meninges Intra-Operative Injury, CTCAE


Retinoblastoma by AJCC v8 Stage

description: A term that refers to the staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to central nervous system component of "trilateral retinoblastoma" (is staged according to the classification for brain and spinal cord), retinoma (or retinocytoma) (no AJCC staging system), and medulloepithelioma (no AJCC staging system). (from AJCC 8th Ed.)


name: Papillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma cN0 TNM Finding v8

description: No evidence of locoregional lymph node metastasis. (from AJCC 8th Ed.)


Serious Adverse Drug Reaction

description: A noxious and unintended response to a medicinal product occurring at any dose that results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in a persistent or significant disability/incapacity, or results in a congenital anomaly/birth defect.


name: Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of moderate epithelial atypia.


name: Grade 3 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Gestational Trophoblastic Neoplasm Clinical Distant Metastasis TNM Finding v8

description: A clinical finding about one or more characteristics of a gestational trophoblastic neoplasm, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Hemiplegia, Unspecified Affecting Right Dominant Side

description: Evidence of hemiplegia, unspecified affecting right dominant side.


Grade 5 Bullous Dermatitis, CTCAE

description: Death


name: Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Hip

description: Evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified hip.


Cadmium Exposure

description: A finding indicating that an individual has been exposed to cadmium or cadmium-containing compounds.


Grade 3 Endophthalmitis, CTCAE

description: Systemic intervention; hospitalization indicated


name: Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Oropharyngeal (p16-Negative) Cancer Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of p16-negative oropharyngeal cancer, following the rules of the TNM AJCC v8 classification system.


name: Unresectable Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that is not amenable to surgical resection.


name: Merkel Cell Carcinoma pM1c TNM Finding v8

description: Merkel cell carcinoma with metastasis to all other distant sites, microscopically confirmed. (from AJCC 8th Ed.)


Grade 3 Breast Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; severe infection; axillary adenitis


name: Other Rheumatoid Arthritis with Rheumatoid Factor of Unspecified Site

description: Evidence of other rheumatoid arthritis with rheumatoid factor of unspecified site not specified elsewhere.


Prior Invasive Malignancy

description: A finding indicating the presence of a previously diagnosed invasive malignant neoplasm.


name: Urethral Cancer Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.


Grade 2 Seroma, CTCAE

description: Symptomatic; simple aspiration indicated


name: No Sequelae of Intervention for Kawasaki Disease

description: An indication that no sequelae were noted following treatment for Kawasaki disease.


name: Grade 3 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Regional Lymph Nodes Clinical Cancer

description: Evidence of regional lymph nodes clinical cancer.


Thoracoschisis

description: A congenital fissure of the thoracic wall.


name: Grade 4 Edema of the Head and Neck, CTCAE


Uterine Corpus Carcinoma TNM Finding v7

description: A finding about one or more characteristics of uterine corpus carcinoma, following the rules of the TNM AJCC v7 classification system.  Carcinosarcomas should be staged as carcinoma. (from AJCC 7th Ed.)


Grade 3 Hypophosphatemia, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


name: Duodenum/Ampulla/Jejunum/Ileum Neuroendocrine Tumor Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of duodenum/ampulla/jejunum/ileum neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for duodenum/ampulla/jejunum/ileum neuroendocrine tumor. (from AJCC 7th Ed.)


name: Grade 5 Intraoperative Ocular Injury, CTCAE

description: Death


name: Rheumatoid Lung Disease with Rheumatoid Arthritis of Unspecified Elbow

description: Evidence of rheumatoid lung disease with rheumatoid arthritis of unspecified elbow.


Bone Cancer pN1 TNM Finding v8

description: Bone cancer with regional lymph node metastasis. (from AJCC 8th Ed.)


name: Hypopharyngeal Cancer pN2a TNM Finding v8

description: Hypopharyngeal cancer with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


Bladder Cancer pMX TNM Finding v6

description: Bladder cancer in which distant metastasis cannot be assessed. (from AJCC 6th Ed.)


name: Atherosclerosis of Autologous Vein Bypass Graft(s) of Left Leg with Ulceration of Other Part of Foot

description: Evidence of atherosclerosis of autologous vein bypass graft(s) of left leg with ulceration of other part of foot.


name: Grade 2 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Intraepithelial Neoplasia in Barrett Esophagus

description: Glandular intraepithelial neoplasia arising in Barrett esophagus.


name: Type 1 Diabetes Mellitus with Proliferative Diabetic Retinopathy with Traction Retinal Detachment not Involving the Macula, Bilateral

description: Evidence of type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment not involving the macula that is bilateral.


PSA Level Greater than One

description: A blood concentration of prostate specific antigen greater than 1 ng/mL.


name: Adrenal Cancer Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of adrenal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


Grade 3 Hyperkalemia, CTCAE

description: >6.0-7.0 mmol/L; hospitalization indicated


cannabis abuse with intoxication

description: Evidence of cannabis abuse with intoxication.


description: A pathologic TNM finding following neoadjuvant treatment indicating that there is no evidence of primary tumor, lymph nodes, or distal metastases.


Small plaque parapsoriasis

description: A variant of parapsoriasis in which the plaques are small.


name: Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Cervical Cancer TNM Finding v7

description: A finding about one or more characteristics of cervical cancer, following the rules of the TNM AJCC v7 classification system.


name: Grade 2 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Atherosclerosis of Non-Biological Bypass Graft(s) of the Extremities with Gangrene, Left Leg

description: Evidence of atherosclerosis of non-biological bypass graft(s) of the extremities with gangrene in the left leg.


Grade 5 Chylothorax, CTCAE

description: Death


Gallbladder Cribriform Carcinoma

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate with a cribriform growth pattern.


name: Juvenile Arthritis, Unspecified, Left Knee

description: Evidence of juvenile arthritis in the unspecified in the left knee.


name: Grade 1 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Colorectal Cancer pN2b TNM Finding v8

description: Colorectal cancer in which seven or more regional lymph nodes are positive. (from AJCC 8th Ed.)


Grade 2 Anorexia, CTCAE

description: Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated


name: Small Intestine Cancer pT2 TNM Finding v8

description: Small intestine cancer with tumor invading the muscularis propria. (from AJCC 8th Ed.)


name: Grade 2 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Retinoblastoma cTX TNM Finding v7

description: Retinoblastoma in which the primary tumor cannot be assessed. (from AJCC 7th Ed.)


Grade 2 Aspiration, CTCAE

description: Altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen)


name: Grade 4 Lung Intra-Operative Injury, CTCAE


name: Parathyroid Intra-Operative Injury, CTCAE


name: Drug or Chemical Induced Diabetes Mellitus with Moderate Non-Proliferative Diabetic Retinopathy without Macular Edema, Unspecified Eye

description: Evidence of drug or chemical induced diabetes mellitus with moderate non-proliferative diabetic retinopathy without macular edema in an unspecified eye.


name: Grade 4 Gastrointestinal Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Accelerated Phase Myeloproliferative Neoplasm

description: Rapid progression of a myeloproliferative neoplasm, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


Skin lesion

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of skin.


name: Refractory EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: EBV-associated lymphoproliferative disease with primary immunodeficiency that is resistant to treatment.


Rheumatoid Nodule, Left Wrist

description: Evidence of rheumatoid nodule in the left wrist.


Overt Primary Myelofibrosis

description: Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


name: Grade 3 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


name: Modified Overall Immune Related Response Criterion, Complete Remission

description: The evaluation of the antitumor response shows a complete disappearance of all lesions (whether measurable or not) and no new lesions. All measurable lymph nodes also have a reduction in short axis diameter to 10 mm.


Grade 1 Serum Amylase Increased, CTCAE

description: >ULN-1.5 x ULN


Perineal Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus.


ROS1 Fusion Negative

description: An indication that the expression of a fusion involving ROS1 has not been detected in a sample.


Microsatellite Stable

description: Indicates that no positive loci have been detected in the microsatellite instability (MSI) biomarkers in a sample.


Grade 3 Pericarditis, CTCAE

description: Pericarditis with physiologic consequences (e.g., pericardial constriction)


Flashing Lights, CTCAE

description: A disorder characterized by a sudden or brief burst of light.


Atelectasis, CTCAE

description: A disorder characterized by the collapse of part or the entire lung.


name: Grade 5 Supraventricular Tachycardia, CTCAE

description: Death


name: Other Hemorrhagic Disorder due to Intrinsic Circulating Anticoagulants, Antibodies, or Inhibitors

description: Evidence of other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors not specified elsewhere.


name: Grade 1 Fever Without Neutropenia, CTCAE


name: Left Ventricular Diastolic Dysfunction, CTCAE

description: An adverse event characterized by impaired functioning of the left ventricle of the heart during the diastole phase of the cardiac cycle.


Radiating Chest Pain in Sternum

description: The location of the radiating chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


Reduced WAS Protein Expression

description: An indication that reduced expression of Wiskott-Aldrich Syndrome protein (WASP; WASp) has been detected in a sample.


Pleural Mesothelioma pN3 TNM Finding v7

description: Pleural mesothelioma with metastases in the contralateral mediastinal, contralateral internal mammary, ipsilateral or contralateral supraclavicular lymph nodes. (from AJCC 7th Ed.)


name: Stage IIIC2 Uterine Corpus Cancer AJCC v7

description: Stage IIIC2 includes: T1-T3, N2, M0. T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue.  N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Merkel Cell Carcinoma cM0 TNM Finding v8

description: Merkel cell carcinoma without distant metastasis detected on clinical and/or radiologic examination. (from AJCC 8th Ed.)


Cutaneous Melanoma pM1d TNM Finding v8

description: Cutaneous melanoma with distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease.  LDH level not recorded or unspecified. (from AJCC 8th Ed.)


name: Grade 3 Upper Gastrointestinal Hemorrhage NOS, CTCAE


name: Unspecified Malignant Neoplasm Skin of Unspecified Upper Limb, Including Shoulder

description: Evidence of unspecified malignant neoplasm skin of unspecified upper limb including the shoulder.


name: Increasing Levels of Measurable Residual Disease

description: A finding indicating an increased presence of residual disease over time.


name: Esophagus and Esophagogastric Junction Cancer pT0 TNM Finding v7

description: Esophagus and esophagogastric junction cancer with no evidence of a primary tumor. (from AJCC 7th Ed.)


Abnormal Blood Gonadotrophin

description: A laboratory test result which indicates abnormal levels of gonadotrophin hormone in the blood.


Laryngeal Obstruction, CTCAE

description: A disorder characterized by blockage of the laryngeal airway.


Tumor Pain

description: A painful sensation caused by the tumor growth.


name: Grade 4 Alkaline Phosphatase Increased, CTCAE

description: >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


name: Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Aneurysm of Other Precerebral Arteries

description: Evidence of aneurysm of other precerebral arteries.


Grade 1 Hyperuricemia, CTCAE

description: >ULN without physiologic consequences


Acute Myeloid Leukemia with del(12p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 12 [del(12p)].


name: Malignant neoplasm of peripheral nerves of upper limb, including shoulder

description: Evidence of a malignant neoplasm of the peripheral nerves of upper limb including the shoulder.


Global Partial Response in Viscera

description: 50 percent or greater regression in any splenic or liver nodules, or in measurable disease (sum of products of diameter) in any organs abnormal at baseline; no increase in size of liver or spleen and no new sites of involvement.


Grade 4 Duodenal Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Mucosal-Dominant Pemphigus Vulgaris

description: A subtype of pemphigus vulgaris in which lesions are predominantly found on mucosal membranes with relative sparing of cutaneous tissues.


name: Grade 3 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Glottic Cancer pT4a TNM Finding v7

description: Glottic cancer with moderately advanced local disease.  Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). (from AJCC 7th Ed.)


name: Grade 4 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Renal Pelvis and Ureter Cancer pN2 TNM Finding v8

description: Renal pelvis and ureter cancer with metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. (from AJCC 8th Ed.)


Grade 4 Guillain-Barre Syndrome, CTCAE

description: Life-threatening consequences; urgent intervention indicated; intubation


Metastatic Biliary Tract Carcinoma

description: A biliary tract carcinoma that has spread from the original site of growth to other anatomic sites.


Cervical Glandular Neoplasm

description: A benign, malignant, or precancerous neoplasm that arises from the glandular epithelium of the cervix. Representative examples include endocervical polyp, cervical adenocarcinoma, and cervical glandular intraepithelial neoplasia.


Thromboembolic Event, CTCAE

description: A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream.


Digestive System Cancer TNM Finding v6

description: A finding about one or more characteristics of digestive system cancer, following the rules of the TNM AJCC v6 classification system.


name: Grade 5 Esophagus Stricture or Stenosis, CTCAE


Drug Exposure

description: Contact with drug.


Grade 4 Anorectal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Metastatic Bladder Micropapillary Urothelial Carcinoma

description: Bladder micropapillary urothelial carcinoma that has spread to another anatomic site.


name: Other Paralytic Syndrome following Other Non-Traumatic Intracranial Hemorrhage Affecting Left Dominant Side

description: Evidence of other paralytic syndrome following other non-traumatic intracranial hemorrhage affecting left dominant side not specified elsewhere.


Gamma-Glutamyltransferase Increased

description: Increase in the level of the enzyme gamma-glutamyltransferase in the blood, which catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, aminoacids, or water.


Retinal Tear, CTCAE

description: A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters.


name: Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8

description: Advanced stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Grade 5 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Other Atherosclerosis of Non-Biological Bypass Graft(s) of the Extremities, Right Leg

description: Evidence of other atherosclerosis of non-biological bypass graft(s) of the extremities in the right leg not specified elsewhere.


Stage IIA Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


Refractory Disease

description: A disease that resists treatment.


name: Grade 3 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


name: Rheumatoid Heart Disease with Rheumatoid Arthritis of Right Elbow

description: Evidence of rheumatoid heart disease with rheumatoid arthritis of right elbow.


name: Occlusion and stenosis of cerebellar arteries

description: Evidence of occlusion and stenosis of cerebellar arteries.


Behavioral insomnia of childhood

description: A childhood disorder characterized by difficulty initiating and maintaining sleep due to negative sleep associations, refusal to go to bed, and/or repeated attempts to delay bedtime.


Grade 1 Wound Infection, CTCAE

description: Localized, local intervention indicated


name: Rheumatoid Lung Disease with Rheumatoid Arthritis of Right Knee

description: Evidence of rheumatoid lung disease with rheumatoid arthritis of right knee.


name: Adverse Event Associated with Pulmonary and Upper Respiratory Systems


name: Malignant Central Nervous System Germ Cell Tumor

description: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics.  Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma.


Hodgkin's lymphoma of CNS

description: A Hodgkin lymphoma that arises from the central nervous system.


name: Grade 2 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Renal Pelvis and Ureter Cancer cM0 TNM Finding v8

description: Renal pelvis and ureter cancer without evidence of distant metastasis. (from AJCC 8th Ed.)


name: Grade 3 Laryngeal Nerve Dysfunction, CTCAE


name: Grade 1 Biliary Tree NOS Intra-Operative Injury, CTCAE


name: Grade 2 Bone Intra-Operative Injury, CTCAE


Grade 3 Aortic Injury, CTCAE

description: Severe symptoms; limiting self care ADL; repair or revision indicated


name: Enteropathic Arthropathies, Unspecified Hip

description: Evidence of enteropathic arthropathies in an unspecified hip.


name: Papillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pM1 TNM Finding v8

description: Distant metastasis. (from AJCC 8th Ed.)


name: Esophagus and Esophagogastric Junction Cancer pN3 TNM Finding v8

description: Esophagus and esophagogastric junction cancer with metastasis in seven or more regional lymph nodes. (from AJCC 8th Ed.)


name: Type 2 Diabetes Mellitus with Mild Nonproliferative Diabetic Retinopathy with Macular Edema

description: Evidence of type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema.


name: Grade 3 Trachea Obstruction and Stenosis, CTCAE


name: Other specified types of non-Hodgkin lymphoma, intrathoracic lymph nodes

description: Evidence of other specified types of non-Hodgkin lymphoma in the intrathoracic lymph nodes not specified elsewhere.


Grade 3 Toothache, CTCAE

description: Severe pain; limiting self care ADL


Vaginal Mucinous Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma.


name: Left Posteromedial Middle Peripheral Zone of Prostate

description: The region of the prostate that is located on the anatomical left side of the posteromedial portion of the middle division of the peripheral zone.


PSA Level Greater than or Equal to 0.05

description: A blood concentration of prostate specific antigen greater than or equal to 0.05 ng/mL.


Posterior Subcapsular Cataract Grade 1

description: A stage of posterior subcapsular cataract characterized by 3% of the posterior capsule obscured by opacity. (Modified LOCS II)


name: Atherosclerosis of Non-Autologous Biological Bypass Graft(s) of the Extremities with Rest Pain, Right Leg

description: Evidence of atherosclerosis of non-autologous biological bypass graft(s) of the extremities with rest pain in the right leg.


name: Grade 1 Other Allergy and Immunology, CTCAE


name: Lip and Oral Cavity Cancer pN3a TNM Finding v8

description: Lip and oral cavity cancer with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-). (from AJCC 8th Ed.)


Infant Acute Lymphoblastic Leukemia

description: An acute lymphoblastic leukemia that occurs in infancy.


name: Other Specified Diabetes Mellitus with Severe Nonproliferative Diabetic Retinopathy with Macular Edema, Right Eye

description: Evidence of other specified diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema in the right eye not specified elsewhere.


Brachial Plexopathy, CTCAE 5.0

description: A disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.


name: Simple Endometrial Hyperplasia without Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is absent.


Grade 5 Fracture, CTCAE

description: Death


name: Locally Advanced Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 3 Jejunum Intra-Operative Injury, CTCAE


name: Type 2 Diabetes Mellitus with Diabetic Autonomic Polyneuropathy

description: Evidence of type 2 diabetes mellitus with diabetic autonomic polyneuropathy.


Gallbladder Cancer pT2a TNM Finding v8

description: Gallbladder cancer with tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). (from AJCC 8th Ed.)


name: Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Myelodysplastic Disease, not Classified

description: Evidence of myelodysplastic disease, not classified.


name: Follicular Lymphoma Grade III, Unspecified, Extranodal and Solid Organ Sites

description: Evidence of unspecified follicular lymphoma grade III in the extranodal and solid organ sites.


name: Non-insulin-dependent diabetes mellitus with unspecified complications

description: Evidence of type 2 diabetes mellitus with unspecified complications.


Neonatal Deformity

description: A congenital anatomic abnormality manifested during the neonatal period.


name: Stage IIIB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 4 Pulmonary Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Chronic Post-Rheumatic Arthropathy, Other Specified Site

description: Evidence of chronic post-rheumatic arthropathy in another specified site.


Grade 1 Vitreous Hemorrhage, CTCAE

description: Intervention not indicated


name: Finding About Event or Intervention Test

description: A character or string that represents a finding of the event or intervention.


name: Grade 4 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Protocol Error Artifact

description: An image of reduced quality resulting from the use of incorrect or incomplete instructions.


name: Grade 4 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervicitis Infection, CTCAE

description: A disorder characterized by an infectious process involving the uterine cervix.


Retracted Tympanometry Result

description: A tympanometry test result indicating the retraction of the tympanic membrane resulting from negative ear pressure.


Breast Papillary Ductal Hyperplasia

description: Benign papillary proliferation within the ductal system of the breast parenchyma.


name: Best Secondary Endpoint Response Registered from Start of Therapy to a Time Point of Interest

description: The most favorable response measured for a secondary endpoint recorded from the start of the treatment until a specified time point in a study.


name: Airway disease due to other specific organic dusts

description: Evidence of airway disease due to other specific organic dusts.


Adenosarcoma pT0 TNM Finding v7

description: No evidence of primary tumor. (from AJCC 7th Ed.)


name: Grade 3 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Benign Urinary Tract Neoplasm

description: A neoplasm that arises from the organs that comprise the urinary tract and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 5 Rectal Ulcer, CTCAE

description: Death


name: Primary Mediastinal (Thymic) Large B-Cell Lymphoma, Lymph Nodes of Head, Face, and Neck

description: Evidence of primary mediastinal (thymic) large B-cell lymphoma in the lymph nodes of the head of the face and neck.


name: Lymphocyte-Depleted Classic Hodgkin Lymphoma, Lymph Nodes of Inguinal Region and Lower Limb

description: Evidence of lymphocyte-depleted classic Hodgkin lymphoma in the lymph nodes of inguinal region and lower limb.


name: Conjunctival Carcinoma pT3 TNM Finding v8

description: Conjunctival carcinoma with tumor invading adjacent structures (excluding the orbit). (from AJCC 8th Ed.)


Somatic-Type Malignancy

description: A malignant non-germ cell component that typically develops secondarily within a germ cell tumor. The malignant cellular component is usually sarcomatous or carcinomatous.


name: Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Intraoperative Urinary Injury, CTCAE


Stage IIB Pancreatic Cancer AJCC v8

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Mixed Cellularity Classic Hodgkin Lymphoma, Intrapelvic Lymph Nodes

description: Evidence of mixed cellularity classic Hodgkin lymphoma, intrapelvic lymph nodes.


Non-Neoplastic Thymus Disorder

description: A non-neoplastic disorder that affects the thymus.  Representative examples include acute thymic involution and thymic hyperplasia.


name: Postoperative Spindle Cell Nodule of the Bladder

description: A benign, reactive lesion of the bladder, occurring status post bladder instrumentation; histologic exam demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the bladder wall without atypia or necrosis.


Microinvasive Anal Carcinoma

description: Anal carcinoma with minimal stromal invasion.


Subgaleal hemorrhage

description: Bleeding between the scalp and the periosteum.


Melanoma of Unknown Primary

description: A melanoma which has metastasized from an unknown primary anatomic site.


Unresectable Malignant Neoplasm

description: A malignant neoplasm which is not amenable to surgical resection.


name: Other Psychoactive Substance Dependence with Intoxication Delirium

description: Evidence of other psychoactive substance dependence with intoxication delirium not specified elsewhere.


CTCAE v4 Grade 4

description: An adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken.


name: Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma pN1b TNM Finding v8

description: Ovarian, fallopian tube, or primary peritoneal carcinoma with metastasis more than 10 mm in greatest dimension. (from AJCC 8th Ed.)


Head and Neck Cancer pN3 TNM Finding v8

description: Head and neck cancer with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastases in a single ipsilateral lymph node larger than 3 cm and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes, any with ENE(+). (from AJCC 8th Ed.)


Grade 1 Abdominal Distension, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IV Osteosarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 4 Multi-Organ Failure, CTCAE

description: Life-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis)


name: Grade 3 Blood Gonadotrophin Abnormal, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 2 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Neonatal apneic attack

description: Apnea occurring during the neonatal period.


Grade 4 Colonic Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Sneezing, CTCAE

description: A disorder characterized by the involuntary expulsion of air from the nose.


EGFR Gene Alteration Negative

description: An indication that mutation, overexpression, fusion or rearrangement involving the EGFR gene has not been detected in a sample.


pN0 (mol+) TNM Finding

description: A regional lymph node TNM finding indicating that there is no evidence of regional lymph node metastasis histologically and by immunohistochemistry, but the molecular analysis (RT-PCR) is positive.


description: Evidence of opioid abuse with intoxication with perceptual disturbance.


name: Oropharyngeal (p16-Negative) Cancer cM1 TNM Finding v8

description: Oropharyngeal (p16-negative) cancer with distant metastasis. (from AJCC 8th Ed.)


name: Right Posteromedial Middle Peripheral Zone of Prostate

description: The region of the prostate that is located on the anatomical right side of the posteromedial portion of the middle division of the peripheral zone.


name: Soft Tissue Sarcoma of the Head and Neck cM0 TNM Finding v8

description: Soft tissue sarcoma of the head and neck without distant metastasis. (from AJCC 8th Ed.)


M1 TNM Finding

description: A clinical and/or pathologic distant metastasis TNM finding indicating the spread of cancer to distant anatomic sites.


name: Locally Advanced Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IIIB Appendix Carcinoma AJCC v7

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  T4: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invades other organs or structures.  N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Hypopharyngeal Cancer pTX TNM Finding v8

description: Hypopharyngeal cancer in which the primary tumor cannot be assessed. (from AJCC 8th Ed.)


Dialysis Catheter Embolism

description: An obstruction of a vessel caused by a detached fragment of an indwelling dialysis catheter.


Grade 3 Erectile Dysfunction, CTCAE

description: Decrease in erectile function (frequency/rigidity of erections) but erectile intervention not helpful (e.g., medication or mechanical devices such as penile pump); placement of a permanent penile prosthesis indicated (not previously present)


name: Localization-Related Symptomatic Epilepsy and Epileptic Syndromes with Simple Partial Seizures, not Intractable, with Status Epilepticus

description: Evidence of localization-related symptomatic epilepsy and epileptic syndromes with simple partial seizures with status epilepticus that responds to treatment.


Grade 2 Injury To Jugular Vein, CTCAE

description: Repair or revision not indicated


name: Grade 1 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Pathologic Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Grade 2 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Fusion-Negative Rhabdomyosarcoma

description: A rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


name: Entry of Unsaturated Spins Into the Volume

description: An artifact resulting from the flow of unsaturated spins into the imaged slice.


name: Grade 3 Spermatic Cord Stricture or Stenosis, CTCAE


name: Grade 1 Central Nervous System Necrosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Metastatic Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread to another anatomical site.


Smoke Exposure

description: Environmental, occupational or consumer-based exposure to airborne gases and particulates produced when materials undergo combustion or thermal decomposition.


name: Transplant-Related Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises in a patient with a history of organ transplantation.


Refractory Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma that is resistant to treatment.


Jaccoud Arthropathy, Left Shoulder

description: Evidence of Jaccoud arthropathy in the left shoulder.


name: Lung Cancer Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of lung cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.


name: Grade 5 Left Ventricular Systolic Dysfunction, CTCAE

description: Death


name: Grade 4 Abdomen Soft Tissue Necrosis, CTCAE


name: Cutaneous Squamous Cell Carcinoma of the Head and Neck pN2a TNM Finding v8

description: Cutaneous squamous cell carcinoma of the head and neck with metastasis in a single ipsilateral or contralateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


description: LDH less than 1.5 x N and hCG (mIu/ml) less than 5,000 and AFP (ng/ml) less than 1,000.  N indicates the upper limit of normal for the LDH assay. (AJCC 7th ed.)


name: Mycosis Fungoides and Sezary Syndrome T2 TNM Finding v8

description: Patches, papules, or plaques covering 10% or more of the skin surface.  (from AJCC 8th Ed.)


Reinfection

description: A second infection by the same pathogen that follows a period of recovery.


Immunotoxicity

description: Toxicity that impairs or damages the immune system.


name: Acute Myeloid Leukemia with Mutated TP53

description: Acute myeloid leukemia characterized by the presence of TP53 gene mutations. There are 20% or more blasts in bone marrow or peripheral blood.


Accessory Urethral Gland Neoplasm

description: A benign or malignant, primary or metastatic neoplasm affecting the accessory urethral gland.


Grade 2 Retinopathy, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


name: Grade 4 Heart Intra-Operative Injury, CTCAE


name: Grade 4 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Multiple Tumor Masses

description: A finding indicating the presence of more than two tumor masses in a single anatomic site or different anatomic sites.


name: Rheumatoid Arthritis without Rheumatoid Factor, Unspecified Hand

description: Evidence of rheumatoid arthritis without rheumatoid factor in an unspecified hand.


name: HPV-Mediated (p16-Positive) Oropharyngeal Cancer pT0 TNM Finding v8

description: No primary identified. (from AJCC 8th Ed.)


Stage II Gallbladder Cancer AJCC v6

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.)


name: Other Epilepsy, Intractable, without Status Epilepticus

description: Evidence of other epilepsy, without status epilepticus that does not respond optimally to treatment not specified elsewhere.


Eyelid Carcinoma pM1 TNM Finding v8

description: Eyelid carcinoma with distant metastasis. (from AJCC 8th Ed.)


name: Bladder Cancer Pathologic Distant Metastasis TNM Finding v6

description: A pathologic finding about one or more characteristics of bladder cancer, following the rules of the TNM AJCC v6 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


Tumor Complete Metabolic Response

description: A finding of disappearance of metabolic tumor activity in target and non-target lesions, marked by a decrease in tumor standardized uptake value to the level of surrounding normal tissue.


CTNNB1 Gene Mutation Negative

description: A genetic finding indicating that CTNNB1 gene mutations have not been detected in a sample.


name: Grade 3 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Lip and Oral Cavity Cancer pM1 TNM Finding v8

description: Lip and oral cavity cancer with distant metastasis. (from AJCC 8th Ed.)


name: Ampulla of Vater Undifferentiated Carcinoma

description: An aggressive carcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of malignant epithelial cells without evidence of glandular or squamous differentiation.  Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.


name: Possible Adverse Event Attribution to Product or Procedure

description: Possible adverse event relationship to study product or procedure is defined when there is less clear temporal association between product or procedure administration and adverse event, and other etiologies of the event are also possible.


name: Complete Response with Incomplete Bone Marrow Recovery

description: The disappearance of all signs of cancer in response to treatment accompanied by incomplete bone marrow recovery, as evidenced by persistent anemia, thrombocytopenia or neutropenia.


Grade 5 Wound Infection, CTCAE

description: Death


name: Clinical Stage II Retinoblastoma AJCC v8

description: Stage II includes: cT4a, cN0, cM0, Any H. cT4a: Radiologic evidence of retrobulbar optic nerve involvement or thickening of optic nerve or involvement of orbital tissues. cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Grade 4 Bronchopulmonary Hemorrhage, CTCAE

description: Life-threatening consequences; intubation or urgent intervention indicated


Peripheral Hemangioblastoma

description: A hemangioblastoma that arises from peripheral nerves or extraneural tissues.


Non-Ossifying Fibroma

description: A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone.


Digitalis toxicity

description: Acute CNS, visual, GI, and cardiac disturbances caused by an overdose of, or intolerance to, the cardiac glycoside, digitalis.


Grade 1 Dry Mouth, CTCAE

description: Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min


Normal Phenolsulfonphthalein Test

description: A laboratory test result indicating normal parameters after a phenolsulfonphthaliein test.


Grade 2 Uterine Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Hypopharyngeal Cancer pT3 TNM Finding v6

description: Hypopharyngeal cancer with tumor size more than 4 centimeters in greatest dimension, or with fixation of the hemilarynx. (from AJCC 6th Ed.)


Mushroom-Shaped Lesion

description: A lesion having the shape of a mushroom.


name: Oropharyngeal (p16-Negative) Cancer cN2 TNM Finding v8

description: Oropharyngeal (p16-negative) cancer with metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Hodgkin's Paragranuloma Involving Spleen

description: An obsolete term that includes cases currently classified as nodular lymphocyte predominant Hodgkin lymphoma with splenic involvement.


name: Other Psychoactive Substance Dependence with Psychoactive Substance-Induced Psychotic Disorder, Unspecified

description: Evidence of other psychoactive substance dependence with psychoactive substance-induced psychotic disorder not specified elsewhere.


name: Breast Cancer pT4c TNM Finding v6 and v7

description: Breast cancer with extension to the chest wall, not including the pectoralis muscle, and with edema (including peau d'orange) or ulceration of the skin of the breast or satellite skin nodules confined to the same breast. (from AJCC 6th and 7th Eds.)


Stage IB1 Cervical Cancer AJCC v8

description: Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic/Recurrent Disease

description: A disease that reappears at its original location or that newly-occurs at a distant location.


Rearrangement Negative

description: An indication that cytogenetic rearrangements were not detected in a sample.


Grade 4 Pancreatitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Type 2 Diabetes Mellitus with Proliferative Diabetic Retinopathy with Combined Traction Retinal Detachment and Rhegmatogenous Retinal Detachment, Left Eye

description: Evidence of type 2 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment in the left eye.


Grade 1 Intracranial Hemorrhage, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Malignant Neoplasm of Upper-Inner Quadrant of Right Female Breast

description: Evidence of a malignant neoplasm of the upper-inner quadrant of right female breast.


Testicular Cancer pT2 TNM Finding v7

description: Testicular cancer with tumor limited to the testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis. (from AJCC 7th Ed.)


Stage IIA Cervical Cancer AJCC v8

description: Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


name: Malignant neoplasm of other specified male genital organs

description: Evidence of a malignant neoplasm of other specified male genital organs.


name: Grade 3 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Unspecified Atherosclerosis of Native Arteries of Extremities, Left Leg

description: Evidence of unspecified atherosclerosis of native arteries of extremities in the left leg.


Liver Radiation Injury

description: Radiation injury of the liver.


name: Breast Cancer pN3a TNM Finding v6 and v7

description: Breast cancer with metastases in 10 or more axillary lymph nodes (at least one tumor deposit greater than 2.0 mm); or metastases to the infraclavicular (level III axillary) lymph nodes. (from AJCC 6th and 7th Eds.)


name: Grade 2 Sacral Plexus Intra-Operative Injury, CTCAE


BRCA-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family.


Post-Procedural Hepatic Failure

description: Evidence of post-procedural hepatic failure.


Blood Bicarbonate Increased

description: Higher than normal levels of bicarbonate in the blood.


Tachyarrhythmia

description: A disorder characterized by an arrhythmia with an above normal rate.


Grade 2 Ovarian Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Grade 4 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Kidney Infection, CTCAE

description: Death


Regional Lymph Nodes Pathology Cancer

description: Evidence of regional lymph nodes pathology cancer.


Wood Dust Exposure

description: Environmental or occupational exposure to granular solids generated when timber is processed, such as when it is chipped, sawed, turned, drilled or sanded.


name: Recurrent Low Grade Endometrioid Adenocarcinoma

description: The reemergence of low-grade endometrioid adenocarcinoma after a period of remission.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol.


name: Cutaneous Melanoma Clinical TNM Finding v7

description: A clinical finding about one or more characteristics of cutaneous melanoma, following the rules of the TNM AJCC v7 classification system. TNM clinical findings are based on clinical/radiographic examinations.  The TNM clinical and pathologic primary tumor classifications of cutaneous melanoma are the same.  The TNM clinical and pathologic regional lymph nodes tumor classifications of cutaneous melanoma are not the same. (from AJCC 7th Ed.)


Urethral Cancer pN0 TNM Finding v7

description: Urethral cancer with no regional lymph node metastasis. (from AJCC 7th Ed.)


name: Grade 3 Vagina Intra-Operative Injury, CTCAE


name: Grade 2 Neuroendocrine ACTH Deficiency, CTCAE


Grade 1 Vaginal Inflammation, CTCAE

description: Mild discomfort or pain, edema, or redness


Grade 3 Duodenal Fistula, CTCAE

description: Invasive intervention indicated


Benign Apocrine Neoplasm

description: An epithelial neoplasm that arises from the apocrine glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 3 Conjunctiva Intra-Operative Injury, CTCAE


Grade 1 Rectal Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Non-Neoplastic Tracheal Disorder

description: A non-neoplastic disorder that affects the trachea.  Representative examples include tracheitis, tracheal agenesis, and tracheal atresia.


name: Type 1 Diabetes Mellitus with Diabetic Autonomic (Poly)Neuropathy

description: Evidence of type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy.


Gastroblastoma

description: A very rare biphasic tumor arising in the gastric muscularis propria (usually of the antrum), generally in boys and young men. It is associated with MALAT1-GLI1 gene fusion. (WHO 2019)


name: Oropharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of oropharyngeal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.  Metastases at level VII are considered regional lymph node metastases. (from AJCC 7th Ed.)


name: Skin Squamous Cell Carcinoma or Other Skin Carcinomas pN3 TNM Finding v7

description: Skin squamous cell carcinoma or other skin carcinomas with metastasis in a lymph node, more than 6 cm in greatest dimension.  (from AJCC 7th Ed.)


Mismatch Repair Protein Proficient

description: Indicates that normal concentrations of unmutated mismatch repair proteins have been detected in a sample.


Gallbladder Cancer cM0 TNM Finding v8

description: Gallbladder cancer without evidence of distant metastasis. (from AJCC 8th Ed.)


Grade 3 Constipation, CTCAE

description: Obstipation with manual evacuation indicated; limiting self care ADL


name: Intrahepatic Bile Duct Cancer pNX TNM Finding v7

description: Intrahepatic bile duct cancer in which regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


name: Appendix Neuroendocrine Tumor Pathologic Regional Lymph Nodes TNM Finding v8

description: A pathologic finding about one or more characteristics of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.


Cheilognathoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip and upper jaw.


Villous Adenoma of the Urinary Tract

description: An exophytic glandular neoplasm of the urinary tract, morphologically similar to its intestinal counterpart. It usually arises from the bladder and urachus. It often coexists with in situ or infiltrating bladder adenocarcinoma.


Non-Neoplastic Axillary Disorder

description: A non-neoplastic disorder that affects the structures of the axilla.  Representative examples include axillary lymphadenitis and axillary abscess.


Primary Cutaneous NUT Adnexal Carcinoma

description: A very rare carcinoma that arises from adnexal structures in the skin. It is characterized by mutations and rearrangement of the NUT gene. It presents as a papular or nodular lesion and has been described in the hand, shoulder, trunk, and lower limb. Histologically, there is a proliferation of malignant epithelial cells in the dermis and/or subcutaneous tissue. The tumor cells display round nuclei with prominent single nucleoli. Features include the presence of small round ducts and foci of abrupt keratinization.


Hemoglobin Trait

description: A condition in which a person is heterozygous for a globin gene, with a one normal allele and one defective allele.


name: Distal Bile Duct Cancer pNX TNM Finding v8

description: Distal bile duct cancer in which the regional lymph nodes cannot be assessed.  (from AJCC 8th Ed.)


name: Grade 5 Neonatal Intraventricular Hemorrhage, AE

description: An intraventricular hemorrhage adverse event in a newborn which results in death.


HIV lipodystrophy

description: A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat.  It is associated with antiretroviral therapy.  Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs.


Quadriplegia, C5-C7 Complete

description: Evidence of quadriplegia, C5-C7 complete.


Cortical Cataract Grade 1

description: A stage of cortical cataract characterized by 10% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Stage I Uterine Corpus Cancer AJCC v6

description: Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Melanoma in Situ of Other Part of Trunk

description: Evidence of melanoma in situ of other part of trunk.


Acute synovitis

description: An acute inflammation of a synovial membrane. It is associated with swelling and pain in the affected area.


Stage IIB Anal Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Displacement of biological heart valve graft, sequela

description: Evidence of displacement of biological heart valve graft, sequela.


Metastatic Mucosal Melanoma

description: Mucosal melanoma that has spread from its primary site to another anatomic site.


name: Recurrent Childhood Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma in childhood after a period of remission.


Grade 3 Confusion, CTCAE

description: Severe disorientation; limiting self care ADL


Eyelid Carcinoma pT1c TNM Finding v8

description: Eyelid carcinoma with tumor measuring 10 mm or less in greatest dimension involving the full thickness of the eyelid. (from AJCC 8th Ed.)


t(9;22) Negative

description: A cytogenetic finding indicating that the translocation t(9;22) has not been detected in a sample.


name: Malignant neoplasm arising from pre-existing spiradenocylindroma

description: A carcinoma that arises in a spiradenocylindroma.


name: Grade 3 International Normalized Ratio of Prothrombin Time, CTCAE


Nutritional anemia, unspecified

description: Evidence of nutritional anemia.


name: Grade 2 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Maxillary Sinus Cancer TNM Finding v6

description: A finding about one or more characteristics of maxillary sinus cancer, following the rules of the TNM AJCC v6 classification system.


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of high grade dysplasia.


name: Primary Mediastinal (Thymic) Large B-Cell Lymphoma, Lymph Nodes of Axilla and Upper Limb

description: Evidence of primary mediastinal (thymic) large B-cell lymphoma in the lymph nodes of the axilla and upper limb.


Restrictive Cardiomyopathy, CTCAE

description: A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility.


name: Occlusion and Stenosis of Right Carotid Artery

description: Evidence of occlusion and stenosis of right carotid artery.


Grade 1 Oral Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Lithium Induced Birth Defect

description: Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy.


name: Nasopharyngeal Cancer Clinical TNM Finding v7

description: A clinical finding about one or more characteristics of nasopharyngeal cancer, following the rules of the TNM AJCC v7 classification system.  The assessment is based primarily on inspection and on indirect and direct endoscopy.  Palpation of sites (when feasible) and of neck nodes is essential.  Neurologic evaluation of all cranial nerves is required.  Imaging studies are essential in clinical staging of pharynx tumors.  (from AJCC 7th Ed.)


Hematologic Toxicity

description: A toxicity that impairs or damages the hematologic system.


name: Grade 4 Jugular Vein Intra-Operative Injury, CTCAE


name: Metastatic Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Brain Metastasis Velocity Greater Than or Equal to 4 per Year

description: A finding indicating that the average number of new brain metastases per year after stereotactic radiosurgery is greater than or equal to 4.


name: Platinum-Refractory Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing platinum therapy.


Factor XII Inactivation

description: Presence of inactivating antibodies to factor XII in the blood.


name: Papillary cystadenoma, borderline malignancy

description: A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells forming papillary structures with an absence of stromal invasion.


Grade 1 Bladder Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Toxicity due to Psychiatric Drugs

description: Toxicity that develops due to the administration of psychiatric medications.


Circulating Tumor-Derived DNA Negative

description: An indication that circulating tumor-derived DNA has not been detected in a sample.


Elevated MHC Class II

description: A finding indicating elevated concentrations of MHC class II in a sample.


name: Mediastinal Germ Cell Tumor M0 TNM Finding

description: Mediastinal germ cell tumor without evidence of distant metastasis. (WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart, 2015)


name: Pancreatic Neuroendocrine Tumor pNX TNM Finding v8

description: Pancreatic neuroendocrine tumor in which the regional lymph nodes cannot be assessed.  (from AJCC 8th Ed.)


name: Grade 4 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Post-Dysenteric Arthropathy, Left Hand

description: Evidence of post-dysenteric arthropathy in the left hand.


Rheumatoid Bursitis, Right Hand

description: Evidence of rheumatoid bursitis in the right hand.


name: Conjunctival Carcinoma pT4b TNM Finding v8

description: Conjunctival carcinoma with tumor invading bone. (from AJCC 8th Ed.)


name: Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma pN1 TNM Finding v8

description: Uterine corpus leiomyosarcoma or endometrial stromal sarcoma with regional lymph node metastasis. (from AJCC 8th Ed.)


Pleural Mesothelioma pN2 TNM Finding v7

description: Pleural mesothelioma with metastases in the subcarinal or the ipsilateral mediastinal lymph nodes including the ipsilateral internal mammary and peridiaphragmatic nodes. (from AJCC 7th Ed.)


name: Metastatic Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Distal Bile Duct Cancer pT1 TNM Finding v7

description: Distal bile duct cancer with tumor confined to the bile duct histologically. (from AJCC 7th Ed.)


name: Mycosis Fungoides and Sezary Syndrome N0 TNM Finding v7

description: No clinically abnormal peripheral lymph nodes; biopsy not required.  Note: for node, abnormal peripheral lymph node(s) indicates any palpable peripheral node that on physical examination is firm, irregular, clustered, fixed or 1.5 cm or larger in diameter.  Node groups examined on physical examination include cervical, supraclavicular, epitrochlear, axillary, and inguinal.  Central nodes, which are not generally amenable to pathologic assessment, are not currently considered in the nodal classification unless used to establish N3 histopathology.  (from AJCC 7th Ed.)


name: Benign Outer Hair Sheath and Infundibulum Neoplasm

description: A neoplasm that arises from the outer hair sheath and infundibulum. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: malignant neoplasm of skin of right lower eyelid, including canthus

description: Evidence of unspecified malignant neoplasm of the skin of the right lower eyelid including the canthus.


name: Atherosclerosis of Unspecified Type of Bypass Graft(s) of the Left Leg with Ulceration of Ankle

description: Evidence of atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of ankle.


name: Mycosis Fungoides and Sezary Syndrome B0a TNM Finding v8

description: Clone negative. Note: A T-cell clone is defined by polymerase chain reaction (PCR) or Southern blot analysis of the TCR gene. (from AJCC 8th Ed.)


IDH1 R132H Negative

description: A finding indicating that a mutation of the IDH1 gene encoding the amino acid substitution Arg132His (R132H) in the isocitrate dehydrogenase [NADP] cytoplasmic protein has not been detected in a sample.


name: Juvenile Rheumatoid Arthritis with Systemic Onset, Right Hand

description: Evidence of juvenile rheumatoid arthritis with systemic onset in the right hand.


description: Evidence of secondary malignant neoplasm of other urinary organs.


name: Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Grade 5 Intestinal Stoma Leak, CTCAE

description: Death


Lymphoma, Intermediate-Grade

description: An antiquated term that refers to a non-Hodgkin lymphoma with intermediate grade histologic features.


Olfactory Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the olfactory nerve (first cranial nerve).


name: Grade 4 Prostate Intra-Operative Injury, CTCAE


Non-Neoplastic Splenic Disorder

description: A non-neoplastic disorder that affects the spleen.


Grade 5 Cervicitis Infection, CTCAE

description: Death


Grade 5 Gastric Stenosis, CTCAE

description: Death


name: Grade 4 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 3 Euphoria, CTCAE

description: Severe mood elevation (e.g., hypomania)


Thymic Tumor pN0 TNM Finding v8

description: Thymic tumor without regional lymph node metastasis. (from AJCC 8th Ed.)


SUR1-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the ABCC8 gene result in hyperinsulinism.


Grade 4 Peritoneal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Soft Tissue Sarcoma of the Head and Neck pT4b TNM Finding v8

description: Soft tissue sarcoma of the head and neck with tumor invading the brain parenchyma, prevertebral muscle, central nervous system via perineural spread, or carotid artery encasement. (from AJCC 8th Ed.)


name: Grade 3 Fever Without Neutropenia, CTCAE


name: Gestational Trophoblastic Neoplasm Pathologic Distant Metastasis TNM Finding v8

description: A pathologic finding about one or more characteristics of a gestational trophoblastic neoplasm, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


Non-Malignant Nodule

description: A usually circumscribed and non-metastasizing nodular mass.


name: Stage II Adult Diffuse Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Physical Examination Abnormal Finding

description: An indication or description of any abnormal findings as a result of a physical examination.


Acute Myeloid Leukemia with del(5q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 5 [del(5q)].


name: Atherosclerosis of Autologous Vein Bypass Graft(s) of the Extremities with Intermittent Claudication, Bilateral Legs

description: Evidence of atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication in both legs.


name: Grade 4 Infusion Site Extravasation, CTCAE


Stabbing Pain

description: An intense sensation of discomfort or distress that is sharp and feels as though a knife has penetrated an anatomical location.


Tissue Rarefaction

description: A morphologic finding indicating reduced tissue density.


name: Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB-MYH11

description: An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of acute myeloid leukemia has a favorable prognosis.  (WHO, 2001)


name: Urethral Cancer Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v8 classification system.


name: Grade 2 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Anatomic Response

description: An assessment of the anatomic response (based on changes in size of anatomic structures) of the disease to the therapy.


Grade 2 Gastroparesis, CTCAE

description: Moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention


name: Mucosal Melanoma of the Female Genital Tract

description: A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract.


description: Evidence of rheumatoid vasculitis with rheumatoid arthritis of unspecified site.


name: Rheumatoid Myopathy with Rheumatoid Arthritis of Left Wrist

description: Evidence of rheumatoid myopathy with rheumatoid arthritis of left wrist.


Cutaneous Melanoma pTX TNM Finding v8

description: Cutaneous melanoma in which the primary tumor thickness cannot be assessed (e.g., diagnosis by curettage). Thickness: Not applicable. Ulceration status: Not applicable. (from AJCC 8th Ed.)


Lung Cancer pT1mi TNM Finding v8

description: Lung cancer with minimally invasive adenocarcinoma: adenocarcinoma (3 cm or less in greatest dimension) with a predominantly lepidic pattern and 5 mm or less invasion in greatest dimension. (from AJCC 8th Ed.)


Ampulla of Vater Cancer TNM Finding v8

description: A finding about one or more characteristics of ampulla of Vater cancer, following the rules of the TNM AJCC v8 classification system. This staging system and classification does not apply to well-differentiated neuroendocrine (carcinoid) tumors but does apply to high-grade neuroendocrine carcinomas, such as small cell carcinoma and large cell neuroendocrine carcinoma. (from AJCC 8th Ed.)


Grade 2 Ovarian Rupture, CTCAE

description: Symptomatic and intervention not indicated


Perineal Pain

description: Painful sensation in the perineal area.


name: immune effector cell-associated neurotoxicity syndrome, grade 1

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 7, 8, or 9 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken spontaneously.


name: Grade 5 Intraoperative Arterial Injury, CTCAE

description: Death


Decreased Attention

description: Impaired ability to focus on a subject or idea.


name: Grade 2 Urinary Tract NOS Intra-Operative Injury, CTCAE


name: Gastrointestinal Leak Including Anastomotic Leak, CTCAE


name: Grade 1 Acoustic Nerve Disorder NOS, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Metastatic Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread from its original site of growth to another anatomic site.


name: Gestational Trophoblastic Tumor by FIGO Stage


name: IgG4-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG4.


name: Transitional Cell Intraepithelial Neoplasia


Grade 4 Pneumonitis, CTCAE

description: Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Abscess of axilla

description: A collection of pus that has formed in the axilla.


name: Gastric Neuroendocrine Tumor pT4 TNM Finding v7

description: Gastric neuroendocrine tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. (from AJCC 7th Ed.)


Atheroembolism of renal arteries

description: A cholesterol plaque embolus that has become lodged in the renal vasculature.


name: Malignant Lacrimal Drainage System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the lacrimal drainage system.


Grade 2 Eczema, CTCAE

description: Moderate; topical or oral intervention indicated; additional medical intervention over baseline indicated


Parasite-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific parasite as the causative agent.


Spongioblastoma, Polar

description: A lesion characterized by the presence of neoplastic neuroepithelial cells with palisading nuclei. This lesion implies a morphologic growth pattern and it is not considered a clinicopathological entity.


name: Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant small cells.


Atrophy of breast

description: Involution of the breast parenchyma.


Clinical Cure

description: There are no signs or symptoms of disease in the individual who previously had a disease.


name: Grade 3 Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)