name: Pathologic Stage III Cutaneous Melanoma AJCC v8

description: Stage III includes: IIIA: (T1a/b-T2a, N1a or N2a, M0); IIIB: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0); IIIC: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0); IIID: (T4b, N3a/b/c, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Lung Cancer pT1 TNM Finding v6

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Lung cancer with a tumor size of 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (not invading the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1. (from AJCC 6th Ed.)


Grade 1 Testicular Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 3 Pancreas Intra-Operative Injury, CTCAE


Supraventricular Tachycardia, CTCAE

description: A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles.


Tetrachloroethylene Exposure

description: A finding indicating that an individual has been exposed to tetrachloroethylene.


Pancreatic Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the pancreas.


name: Gallbladder Cancer pT1 TNM Finding v6 and v7

description: Gallbladder cancer with tumor invading the lamina propria or muscle layer. (from AJCC 6th and 7th Eds.)


name: Gastric Cancer Pathologic Distant Metastasis TNM Finding v6

description: A pathologic finding about one or more characteristics of gastric cancer, following the rules of the TNM AJCC v6 classification system as they pertain to distant metastases.


Lesion of cervix

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of the cervix uteri.


Stage I Anal Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or smaller. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Upper Airway Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Grade 3 Infusion Related Reaction, CTCAE

description: Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae


description: A hepatocellular adenoma caused by inactivating mutations of the HNF1A gene.  It is characterized by the presence of lobulated contours, steatosis, and absence of inflammation or nuclear atypia.


name: Clinical Change by Non-Invasive Imaging Procedure

description: Any clinical change to a subject as determined by a non-invasive imaging procedure.


Newly Diagnosed Childhood Ependymoma

description: A recently diagnosed ependymoma during childhood.


name: Lower Extremity Soft Tissue Necrosis, CTCAE


name: Cervical Cancer Clinical Distant Metastasis TNM Finding v9

description: A clinical finding about one or more characteristics of cervical cancer, following the rules of the TNM AJCC v9 classification system as they pertain to distant metastases.


name: Non-Rheumatic Mitral Valve Insufficiency

description: Evidence of non-rheumatic mitral valve insufficiency.


Pharyngeal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the pharynx.


Chest Pain in Mid Sternum

description: The location of the chest pain is in the middle of the sternum.


name: Grade 4 Pleura Intra-Operative Injury, CTCAE


Grade 5 Gallbladder Obstruction, CTCAE

description: Death


name: Bladder Cancer Pathologic TNM Finding v6

description: A pathologic finding about one or more characteristics of bladder cancer, following the rules of the TNM AJCC v6 classification system. TNM pathologic findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


name: Simple Endometrial Hyperplasia with Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is present.


Grade 1 Paronychia, CTCAE

description: Nail fold edema or erythema; disruption of the cuticle


Stage II Cervical Cancer AJCC v7

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Rectal Mucositis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 1 Neck Edema, CTCAE

description: Asymptomatic localized neck edema


name: Childhood Malignant Central Nervous System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the central nervous system and occurs during childhood.


name: Grade 3 Glossopharyngeal Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


Juvenile systemic scleroderma

description: Systemic sclerosis that is diagnosed in children. Juvenile systemic sclerosis is more likely to be of the overlap variant and presents with musculoskeletal involvement.


name: Other central nervous system demyelinating diseases

description: Evidence of other demyelinating diseases of the central nervous system not specified elsewhere.


name: Grade 5 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


name: Diabetes Mellitus due to Underlying Condition with Severe Non-Proliferative Diabetic Retinopathy without Macular Edema, Unspecified Eye

description: Evidence of diabetes mellitus due to underlying condition with severe non-proliferative diabetic retinopathy without macular edema in an unspecified eye.


name: Atherosclerosis of Non-Autologous Biological Bypass Graft(s) of the Right Leg with Ulceration of Thigh

description: Evidence of atherosclerosis of non-autologous biological bypass graft(s) of the right leg with ulceration of thigh.


Spontaneous Perforation

description: A hole through the wall of an organ that occurs without external influence.


name: Grade 4 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cancer Fatigue

description: A debilitating tiredness or total lack of energy, often reported as the most common symptom in individuals with cancer.  Cancer fatigue can result from chemotherapy, radiation therapy, surgery, and other treatments; chemotherapy-induced anemia is a very frequent cause. -- 2004


Pancreatic Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the pancreas.


name: Grade 4 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Uterine Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures).


Grade 1 Sinus Pain, CTCAE

description: Mild pain


name: Precursor T-lymphoblastic lymphoma/leukemia stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, or nodular involvement of the lungs(s).


Testicular Cancer pM1a TNM Finding v8

description: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. (from AJCC 8th Ed.)


Kaposi's sarcoma of other sites

description: Evidence of Kaposi's sarcoma of other sites.


name: Non-Follicular Diffuse Lymphoma, Unspecified, Lymph Nodes of Head, Face, and Neck

description: Evidence of unspecified non-follicular diffuse lymphoma in the lymph nodes of head, face, and neck.


name: alcohol dependence with alcohol-induced persisting amnestic disorder

description: Evidence of alcohol dependence with alcohol-induce persisting amnestic disorder.


name: Mucosal Melanoma of the Head and Neck pNX TNM Finding v7

description: Mucosal melanoma of the head and neck in which the regional lymph nodes cannot be assessed.  (from AJCC 7th Ed.)


name: Other Specified Diabetes Mellitus with Severe Nonproliferative Diabetic Retinopathy with Macular Edema

description: Evidence of other specified diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema not specified elsewhere.


Cervical Cancer cT1b1 TNM Finding v7

description: Cervical cancer with clinically visible lesion 4.0 cm or less in greatest dimension confined to the cervix. (from AJCC 7th Ed.)


name: Clinical Stage III Retinoblastoma AJCC v8

description: Stage III includes: (cT4b, cN0, cM0, Any H); (Any cT, cN1, cM0, Any H). cT4b: Extraocular tumor clinically evident with proptosis and/or an orbital mass. cN0: No regional lymph node involvement. cN1: Evidence of preauricular, submandibular, and cervical lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma cM1a TNM Finding v8

description: Ovarian, fallopian tube, or primary peritoneal carcinoma with pleural effusion with positive cytology. (from AJCC 8th Ed.)


JAK2 Gene Mutation Negative

description: A genetic finding indicating that JAK2 gene mutations have not been detected in a sample.


Metastatic Melanoma in the Viscera

description: A melanoma that has spread to visceral organs from a cutaneous or extracutaneous primary site.


name: Grade 3 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Spontaneous cerebral hemorrhage

description: Evidence of nontraumatic intracerebral hemorrhage.


name: Nasopharyngeal Cancer pN2 TNM Finding v7

description: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. (from AJCC 7th Ed.)


Adenosarcoma cM0 TNM Finding v7

description: No distant metastasis. (from AJCC 7th Ed.)


Grade 1 Phlebitis Infective, CTCAE

description: Localized, local intervention indicated


PSA Level Greater than Five

description: A blood concentration of prostate specific antigen greater than 5 ng/mL.


name: Cutaneous Melanoma pM1a(0) TNM Finding v8

description: Cutaneous melanoma with distant metastasis to skin, soft tissue including muscle, and/or nonregional lymph node. LDH level not elevated. (from AJCC 8th Ed.)


Stage II Testicular Cancer AJCC v8

description: Stage II includes: Any pT/TX, N1-3, M0, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Grade 4 Urostomy Site Bleeding, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Palpation Finding

description: The results of a palpation examination.


Congenital ankyloblepharon

description: A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue.


name: Grade 3 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cutaneous Melanoma pT4 TNM Finding v8

description: Cutaneous melanoma measuring more than 4.0 mm in thickness. Ulceration status: Unknown or unspecified. (from AJCC 8th Ed.)


RB1 Gene Mutation Negative

description: A genetic finding indicating that RB1 gene mutations have not been detected in a sample.


Spiradenocylindroma

description: A benign adnexal neoplasm with histological features of both spiradenoma and cylindroma in a single nodular lesion.


name: Grade 4 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Mild Protein-Calorie Malnutrition

description: Evidence of mild protein-calorie malnutrition.


Penile Cancer cN2 TNM Finding v8

description: Penile cancer with palpable mobile two or more unilateral inguinal nodes or bilateral inguinal lymph nodes. (from AJCC 8th Ed.)


Midgut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the jejunum, ileum, proximal colon, or appendix.


name: Unspecified Pre-Existing Hypertension Complicating Childbirth

description: Evidence of unspecified pre-existing hypertension complicating childbirth.


Other Juvenile Arthritis, Left Knee

description: Evidence of other juvenile arthritis in the left knee not specified elsewhere.


Patient's Condition Worsened

description: An indication that the patient’s condition has worsened.


name: Grade 4 Ventricular Arrhythmia NOS, CTCAE


name: Greater than 50 Percent Area of Interest on Radiograph

description: A radiographic finding indicating the area of interest is greater than 50 percent.


Reiter's Disease, Unspecified Hip

description: Evidence of Reiter's disease in an unspecified hip.


name: Colorectal Neuroendocrine Tumor cM1a TNM Finding v8

description: Colorectal neuroendocrine tumor with metastasis confined to liver. (from AJCC 8th Ed.)


name: Thrombosis or Thrombus or Embolism, CTCAE


name: Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Facial Pain, CTCAE

description: Mild pain


name: Grade 4 Duodenum Stricture or Stenosis, CTCAE


name: Grade 4 Jejunum Intra-Operative Injury, CTCAE


name: Metastatic Genitourinary System Carcinoma

description: A carcinoma that arises from the genitourinary system and has metastasized to other anatomic sites.


Cutaneous Melanoma cM1 TNM Finding v8

description: Cutaneous melanoma with evidence of distant metastasis. (from AJCC 8th Ed.)


name: Unresectable Anal Squamous Cell Carcinoma

description: Anal squamous cell carcinoma that is not amenable to surgical resection.


Dialysis Catheter Fracture

description: A crack or break in a dialysis catheter caused by material weakness or mechanical compression.


Throat Tightening

description: The sensation of constriction or contraction in the throat area.


Malignant cylindroma of skin

description: A carcinoma that arises in a cylindroma.


Grade 2 Hepatitis Viral, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Penile Cancer Clinical Regional Lymph Nodes TNM Finding v8

description: A clinical finding about one or more characteristics of penile cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.


Grade 5 Obstruction Gastric, CTCAE

description: Death


name: Grade 1 Supraventricular Tachycardia, CTCAE

description: Asymptomatic, intervention not indicated


name: Type 1 Diabetes Mellitus with Proliferative Diabetic Retinopathy with Combined Traction Retinal Detachment and Rhegmatogenous Retinal Detachment, Unspecified Eye

description: Evidence of type 1 diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment in an unspecified eye.


name: Unresectable Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 2 Tracheal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Radiating Chest Pain Along Left Middle Sternal Border

description: The location of the radiating chest pain is along the left middle sternal border.


Non-Neoplastic Hair Disorder

description: A non-neoplastic disorder that affects the hair. Representative examples may include alopecia, male pattern baldness, hirsutism, and hair shaft disorders.


Increased NPN

description: A laboratory test result indicating abnormally high concentration of non-protein nitrogen in the blood.


name: Gastric Cancer pTX TNM Finding v6 and v7

description: Gastric cancer in which the primary tumor cannot be assessed. (from AJCC 6th and 7th Eds.)


Iris Melanoma pT1a TNM Finding v8

description: Iris melanoma with tumor limited to the iris, not more than 3 clock hours in size. (from AJCC 8th Ed.)


name: Grade 5 Intraoperative Musculoskeletal Injury, CTCAE

description: Death


name: High Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


name: Acute Myocardial Injury Related to Acute COVID-19

description: Acute myocardial injury in an individual with probable or confirmed COVID-19 infection and no alternative explanation for acute myocardial injury.


name: Extrapyramidal and movement disorders in diseases classified elsewhere

description: Evidence of extrapyramidal and movement disorder in diseases classified elsewhere.


name: Grade 1 Small Intestinal Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


description: Evidence of hallucinogen abuse with hallucinogen-induced anxiety disorder.


name: Supraglottic Cancer pTis TNM Finding v6 and v7

description: Supraglottic cancer with a finding of carcinoma in situ. (from AJCC 6th and 7th Eds.)


name: Jejunum and Ileum Neuroendocrine Tumor TNM Finding v8

description: A finding about one or more characteristics of a jejunum and ileum neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This classification system applies to small bowel "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3) arising in the jejunum and ileum. This classification system does not apply to high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine tumors of the duodenum. (from AJCC 8th Ed.)


name: Grade 4 Major Visceral Vein Intra-Operative Injury, CTCAE


name: Grade 4 Vein NOS Intra-Operative Injury, CTCAE


name: Lugano Classification Stage IE Adult Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


name: Grade 2 Nose Intra-Operative Injury, CTCAE


Triple-Class Exposed

description: A finding indicating that a plasma cell myeloma patient has received the following three classes of treatment: proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies.


name: Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Hepatitis Sustained Virologic Response

description: A hepatitis negative finding at a predetermined time point after treatment.


name: Melanoma of the Conjunctiva pT(is) TNM Finding v7

description: Melanoma of the conjunctiva confined to the epithelium. (from AJCC 7th Ed.)


Thymic Tumor Clinical TNM Finding v8

description: A clinical finding about one or more characteristics of a thymic tumor, following the rules of the TNM AJCC v8 classification system.


IDH Gene Family Mutation Status Unknown

description: A finding indicating that there is no information regarding the presence or absence of IDH1 or IDH2 gene mutations in a tumor sample.


Grade 3 Iron Overload, CTCAE

description: Severe symptoms; intervention indicated


name: Drug or Chemical Induced Diabetes Mellitus with Diabetic Nephropathy

description: Evidence of drug or chemical induced diabetes mellitus with diabetic nephropathy.


name: Grade 2 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Laryngeal Cancer cN1 TNM Finding v8

description: Laryngeal cancer with metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent

description: Acute myeloid leukemias and myelodysplastic syndromes arising as a result of the mutagenic effect of alkylating agents that are used for the treatment of malignant tumors. Patients usually develop a myelodysplastic syndrome which may evolve to a higher grade myelodysplastic syndrome or acute myeloid leukemia. A minority of patients present with an acute myeloid leukemia. Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7. Patients with acute myeloid leukemia usually do not respond to treatment and have an unfavorable clinical outcome.


Seminal Vesicle Squamous Cell Carcinoma

description: An extremely rare squamous cell carcinoma that arises from the seminal vesicle. Glandular formation and mucin secretion are absent.


PPP2R1A Gene Mutation Negative

description: A genetic finding indicating that PPP2R1A gene mutations have not been detected in a sample.


description: Evidence of manic episode without psychotic symptoms.


Lung Cancer pT3 TNM Finding v8

description: Lung cancer with tumor measuring more than 5 cm but 7 cm or less in greatest dimension or directly invading any of the following: parietal pleura (PL3), chest wall (including superior sulcus tumors), phrenic nerve, parietal pericardium; or separate tumor nodule(s) in the same lobe as the primary. (from AJCC 8th Ed.)


name: Grade 4 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Gastrointestinal Leak NOS, CTCAE


name: Childhood Diffuse Astrocytoma, MYB-Altered

description: A rare diffuse astrocytoma, MYB-altered that occurs during childhood.


name: Mycosis fungoides of intra-abdominal lymph nodes

description: Evidence of mycosis fungoides, intra-abdominal lymph nodes.


name: Glottic Cancer Pathologic Regional Lymph Nodes TNM Finding v6

description: A pathologic finding about one or more characteristics of glottic cancer, following the rules of the TNM classification system as they pertain to staging of regional lymph nodes.


Head and Neck Cancer pN1 TNM Finding v8

description: Head and neck cancer with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (extranodal extension)(-). (from AJCC 8th Ed.)


Supraglottic Cancer pT4b TNM Finding v7

description: Supraglottic cancer with very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. (from AJCC 7th Ed.)


Immunophenotypic Complete Response

description: The disappearance of all signs of cancer, supported by the absence of phenotypically aberrant plasma cells (clonal) in bone marrow. (Rajkumar SV, Harousseau J, Durie B et al, Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1. Blood. 2011; 117(18):4691-4695)


Global Response in Blood

description: Criteria for the response to treatment in blood, as a component of global response.


name: Respiratory, Thoracic and Mediastinal Disorders, CTCAE


Grade 2 Irregular Menstruation, CTCAE

description: Intermittent/irregular menses for more than 3 consecutive menstrual cycles


Infection by human herpesvirus 6

description: An infection that is caused by human herpesvirus-6.


name: Intermediate Grade Lung Neuroendocrine Neoplasm

description: An intermediate grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes atypical carcinoid tumor.


Disorder of AMH Receptor

description: A defect in the Anti-Muellerian hormone receptor.


name: Childhood L2 Acute Lymphoblastic Leukemia

description: L2 acute lymphoblastic leukemia that occurs during childhood.


name: Right Basal Anterior Fibromuscular Stroma of Prostate

description: The portion of the fibromuscular stroma of the prostate that is located on the anatomical right side of the basal division of the anterior lobe.


name: Grade 3 Cranial Nerve X Intra-Operative Injury, CTCAE


name: Peripheral Vascular Angioplasty Status with Implants and Grafts

description: Evidence of peripheral vascular angioplasty status with implants and grafts.


Grade 1 Vulval Infection, CTCAE

description: Localized, local intervention indicated


name: Choroidal and Ciliary Body Melanoma pT2c TNM Finding v8

description: Choroidal and ciliary body melanoma, tumor size category 2 without ciliary body involvement but with extraocular extension 5 mm or less in largest diameter. (from AJCC 8th Ed.)


name: Grade 3 Cranial Nerve VII Neuropathy, CTCAE


Sinonasal Chondromesenchymal Hamartoma

description: A benign, locally destructive, sinonasal tumor-like growth containing mixed mesenchymal elements. (WHO 2017)


name: Grade 2 Breast Function and Lactation, CTCAE


Presence of Heart Assist Device

description: Evidence of presence of heart assist device.


Nodule Shape

description: A description about the radiologic shape of a nodule.


name: Mitochondrial Hydroxyacyl-Coenzyme A Dehydrogenase Hyperinsulinism

description: Hyperinsulinism due to inactivating mutation(s) in the gene HADH, encoding mitochondrial (short-chain) hydroxyacyl-coenzyme A dehydrogenase, resulting in loss of inhibition of glutamate dehydrogenase (GDH). This condition is also characterized by protein-induced hypoglycemia, but in contrast to GLUD1-associated hyperinsulinism, hyperammonemia is absent.


Cutaneous Melanoma cNX TNM Finding v7

description: Cutaneous melanoma in which the regional lymph nodes cannot be assessed (e.g., previously removed for another reason).  (from AJCC 7th Ed.)


Nucleic Acid Synthesis Alteration

description: A finding indicating a deficiency or excess in synthesis of nucleic acids.


name: Ampulla of Vater Cancer cM1 TNM Finding v7

description: Ampulla of Vater cancer with distant metastasis. (from AJCC 7th Ed.)


name: Grade 5 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

description: A cervical squamous cell carcinoma associated with human papillomavirus infection.


Circumferential Endothelial Hyperplasia

description: Intraluminal hyperplasia of endothelial cells, encircling the entire lumen.


FDG-Avid Tumor

description: A radiologic finding indicating high uptake of FDG by a solid tumor during positron emission tomography (PET).


Syncope, CTCAE 5.0

description: A disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain.


name: Cervical Cancer Clinical Distant Metastasis TNM Finding v7

description: A clinical finding about one or more characteristics of cervical cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.


name: Grade 5 Central Nervous System Necrosis, CTCAE

description: Death


Grade 3 Wound Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Skin Squamous Cell Carcinoma or Other Skin Carcinomas pN2c TNM Finding v7

description: Skin squamous cell carcinoma or other skin carcinomas with metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. (from AJCC 7th Ed.)


Grade 4 Neonatal Edema, AE

description: An edema adverse event in a newborn characterized by life threatening consequences (e.g. respiratory failure, shock); requiring urgent major care changes (e.g. intubation, dialysis).


ARID1A Gene Mutation Negative

description: A genetic finding indicating that ARID1A gene mutations have not been detected in a sample.


PSA Level 0.5 to 50

description: A blood concentration of prostate specific antigen between 0.5 and 50 ng/mL.


name: Mechanical Breakdown of Biological Heart Valve Graft, Subsequent

description: Evidence of mechanical breakdown of biological heart valve graft, subsequent.


name: Carcinoma in Situ of Skin of Unspecified Eyelid, Including Canthus

description: Evidence of carcinoma in situ of the skin of unspecified eyelid including the canthus.


name: ALK-negative anaplastic large cell lymphoma of intra-abdominal lymph nodes

description: Evidence of anaplastic large cell lymphoma that is ALK-Negative in the intra-abdominal lymph nodes.


BRD4/NUTM1 Fusion Negative

description: An indication that expression of a BRD4/NUTM1 fusion has not been detected in a sample.


name: Grade 4 Superior Vena Cava Vein Injury, CTCAE


name: Grade 2 Persistent Pulmonary Hypertension of the Newborn, AE

description: An adverse event in a newborn characterized by increased estimated right ventricular pressures; with moderate clinical symptoms; oxygenation index less than 25; minor care changes required.


name: Refractory Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that is resistant to treatment.


name: Grade 4 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Arterial Thromboembolism, CTCAE

description: Life-threatening consequences; hemodynamic or neurologic instability; organ damage; loss of extremity(ies)


Clostridium difficile infection

description: A bacterial infection caused by Clostridium difficile (Clostridioides difficile), which is a spore-forming, toxin-producing Gram-positive anaerobic bacillus that is transmitted by the fecal-oral route. Infection may cause symptoms ranging from diarrhea to life-threatening inflammation of the colon, and risk factors include use of antibiotic medication, advanced age, and hospital or long-term care facility admission.


name: Grade 1 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Grade 4 Spinal Cord Compression, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


name: Malignant Neoplasm of Lower-Inner Quadrant of Left Male Breast

description: Evidence of a malignant neoplasm of the lower-inner quadrant of left male breast.


name: Grade 5 Fallopian Tube Anastomotic Leak, CTCAE

description: Death


Neoplasm, Residual

description: Evidence for remaining tumor following primary treatment that is only apparent using highly sensitive techniques.


Grade 3 Pelvic Pain, CTCAE

description: Severe pain; limiting self care ADL


Stage I Uterine Corpus Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


acute systolic congestive heart failure

description: Acute congestive heart failure due to reduced contractility of the left ventricle.


Index Lesion

description: The most clinically significant tumor lesion targeted by therapy. The lesion is typically the largest or highest graded of the tumor foci detected.


name: Other Specified Diabetes Mellitus with Mild Nonproliferative Diabetic Retinopathy without Macular Edema, Unspecified Eye

description: Evidence of other specified diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema, unspecified eye not specified elsewhere.


Other Juvenile Arthritis, Left Wrist

description: Evidence of other juvenile arthritis in the left wrist not specified elsewhere.


Second degree uterine prolapse

description: The uterus has descended to the level of the hymen.


Grade 2 Hyperkalemia, CTCAE

description: >5.5-6.0 mmol/L; intervention initiated


name: Pre-Existing Essential Hypertension Complicating Childbirth

description: Evidence of pre-existing essential hypertension complicating childbirth.


name: Grade 3 Cranial Nerve VI Neuropathy, CTCAE


name: Grade 4 Other Metabolic and Laboratory, CTCAE


name: Sedative, Hypnotic or Anxiolytic Abuse with Intoxication Delirium

description: Evidence of sedative, hypnotic or anxiolytic abuse with intoxication delirium.


name: Localization-Related Symptomatic Epilepsy and Epileptic Syndromes with Simple Partial Seizures, Intractable, without Status Epilepticus

description: Evidence of localization-related symptomatic epilepsy and epileptic syndromes with simple partial seizures, without status epilepticus that does not respond optimally to treatment.


Atrophic Actinic Keratosis

description: Actinic keratosis characterized by the presence of marked epidermal atrophy.


name: Hemiplegia following Unspecified Cerebrovascular Disease Affecting Left Dominant Side

description: Evidence of hemiplegia following unspecified cerebrovascular disease affecting left dominant side.


Grade 4 Hyperuricemia, CTCAE

description: Life-threatening consequences


name: High grade glandular intraepithelial neoplasia

description: A high grade intraepithelial neoplasia in which there is marked architectural distortion and crowding of the glands, associated with severe cellular atypia. The neoplastic cells display pleomorphic and hyperchromatic nuclei.


Grade 1 Heart Failure, CTCAE

description: Asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities


Pancreatic Enzymes Decreased, CTCAE

description: A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen.


name: Monoplegia of Lower Limb following Non-Traumatic Subarachnoid Hemorrhage Affecting Unspecified Side

description: Evidence of monoplegia of lower limb following non-traumatic subarachnoid hemorrhage affecting unspecified side.


Malignant tumor of epidermal appendage

description: A malignant neoplasm that arises from the skin appendages.


name: Stage III Adult Diffuse Large Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Lipomatosis of Nerve

description: A tumor composed of mature adipocytes and fibrous tissue infiltrating the epineurium and peripheral nerves.  It is often seen at birth or during childhood and may be associated with macrodactyly.


name: Grade 2 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Lower Extremity Intra-Operative Injury, CTCAE


name: Human Papillomavirus-Related Anal Squamous Cell Carcinoma

description: An anal squamous cell carcinoma related to infection with sexually transmittable human papillomavirus.


name: Grade 3 Retroperitoneal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


Helicobacter Pylori-Related Carcinoma

description: A carcinoma that is caused by Helicobacter pylori.


name: Unspecified Juvenile Rheumatoid Arthritis, Unspecified Hand

description: Evidence of unspecified juvenile rheumatoid arthritis in an unspecified hand.


Unresectable Neuroendocrine Tumor

description: A neuroendocrine tumor that is not amenable to surgical resection.


Local infection skin/subcut tissue NOS

description: An infection involving the surface of the skin and subcutaneous tissues in a defined area of the body.


Negative Patch Test

description: A finding that indicates the absence of an immune response to an antigen, which was introduced to the skin by the application of a patch containing the antigen.


Supraglottic Cancer TNM Finding v6

description: A finding about one or more characteristics of supraglottic cancer, following the rules of the TNM AJCC v6 classification system.


Distant Metastases Other Cancer

description: Evidence of distant metastases other cancer.


name: Psychomotor Deficit following Other Cerebrovascular Disease

description: Evidence of psychomotor deficit following other cerebrovascular disease.


name: Stage IIIB Uterine Corpus Cancer AJCC v7

description: Stage IIIB includes: T3b, N0, M0.  T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Grade 2 Pelvic Floor Muscle Weakness, CTCAE

description: Symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental ADL


name: Metastatic Non-Functioning Neuroendocrine Tumor

description: A non-functioning, well-differentiated neuroendocrine neoplasm that has spread from the original site of growth to another anatomic site.


name: Grade 2 Neonatal Respiratory Distress Syndrome, AE

description: An adverse event in a newborn characterized by clinical evidence of increased respiratory distress without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); corrected by minor adjustments in current ventilatory support, supplemental oxygen or non-invasive support.


Grade 1 Small Intestine Ulcer, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: High Grade Prostatic Intraepithelial Neoplasia, Foamy Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of large glands with papillary infoldings that contain cells with xanthomatous cytoplasm.


name: Merkel Cell Carcinoma of Unspecified Ear and External Auricular Canal

description: Evidence of Merkel cell carcinoma of unspecified ear and external auricular canal.


Urinary Incontinence, CTCAE 5.0

description: A disorder characterized by inability to control the flow of urine from the bladder.


Childhood Fibrous Histiocytoma

description: A fibrous histiocytoma that occurs during childhood.


name: Appendiceal Carcinoma pN0 TNM Finding v8

description: Appendiceal carcinoma with no metastasis to regional lymph nodes. (from AJCC 8th Ed.)


name: No Alleviating Factor to Chief Complaint

description: An indication that the chief complaint was not lessened or improved by another factor.


name: Monoclonal B-cell lymphocytosis non-chronic lymphocytic leukemia type

description: Monoclonal B-cell lymphocytosis characterized by the presence of fewer than 5 x 10^9/L abnormal B-lymphocytes in peripheral blood and absence of the characteristic immunophenotype of chronic lymphocytic leukemia. This type of monoclonal B-cell lymphocytosis does not progress to chronic lymphocytic leukemia.


Felty's syndrome of hip

description: Evidence of Felty's syndrome in an unspecified hip.


Lacrimal Drainage System Carcinoma

description: A carcinoma that arises from the lacrimal sac, canaliculi, or nasolacrimal duct.


name: Alcohol Use Complicating Pregnancy, First Trimester

description: Evidence of alcohol use complicating pregnancy in the first trimester.


Laryngeal Cancer pN2b TNM Finding v8

description: Laryngeal cancer with metastases in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


Chronic Intestinal Cryptosporidiosis

description: A chronic infection caused by Cryptosporidium parvum or hominis that manifests as enteritis. It usually occurs in immunocompromised patients including persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies.


Cortical Cataract Grade 2

description: A stage of cortical cataract characterized by 10-50% of the intrapupillary space obscured by opacity. (Modified LOCS II)


name: Grade 3 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Urethral Cancer Pathologic Regional Lymph Nodes TNM Finding v8

description: A pathologic finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.


Automobile Accident

description: An accident occurring while aboard, or involving, an automobile.


name: Otitis External Ear Non Infectious, CTCAE


name: Grade 2 Biliary Tree NOS Intra-Operative Injury, CTCAE


name: Grade 3 Other Hemorrhage and Bleeding, CTCAE


name: Nodular Lymphocyte Predominant Hodgkin Lymphoma, Intrathoracic Lymph Nodes

description: Evidence of nodular lymphocyte predominant Hodgkin lymphoma in the intrathoracic lymph nodes.


Retinoblastoma TNM Finding v7

description: A finding about one or more characteristics of retinoblastoma, following the rules of the TNM AJCC v7 classification system.


Grade 3 Gastritis, CTCAE

description: Severely altered eating or gastric function; TPN or hospitalization indicated


Grade 1 Pancreatic Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 4 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Tumor Hemorrhage, CTCAE

description: Death


FGFR3 Gene Rearrangement Negative

description: A genetic finding indicating that rearrangement of the FGFR3 gene has not been detected in a sample.


name: Grade 5 Upper Respiratory Infection, CTCAE

description: Death


name: Vaccine associated paralytic poliomyelitis

description: A rare, paralytic poliomyelitis associated with the orally administered live attenuated strain of the poliovirus, OPV.


name: Carcinoma of the Eyelid pTis TNM Finding v7

description: Carcinoma of the eyelid with a finding of carcinoma in situ. (from AJCC 7th Ed.)


Prostate Cancer cM1b TNM Finding v7

description: Prostate cancer with metastasis to bone(s). (from AJCC 7th Ed.)


name: Esophageal Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage

description: A term that refers to the postneoadjuvant therapy staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Perihilar Bile Duct Cancer pN0 TNM Finding v8

description: Perihilar bile duct cancer with no metastasis to regional lymph nodes. (from AJCC 8th Ed.)


Diesel Exhaust Exposure

description: Environmental, occupational, or consumer-based exposure to volatiles and particulates present in diesel exhaust.


Lung Cancer pT0 TNM Finding v8

description: Lung cancer without evidence of primary tumor. (from AJCC 8th Ed.)


In situ melanocytic morphology

description: Evidence of in situ melanocytic morphology (morphologic abnormality).


name: Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 2 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Urostomy Obstruction, CTCAE

description: A disorder characterized by blockage of the urostomy.


Stage III Cervical Cancer FIGO 2018

description: Cervical carcinoma that involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para-aortic lymph nodes. (FIGO 2018)


Glottic Cancer pT4b TNM Finding v8

description: Glottic cancer with very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. (from AJCC 8th Ed.)


name: Microbial EC50 Fold Change from Baseline

description: A fold change based on the concentration of a specific drug expected to produce 50 percent inhibition of population growth or replication of a microbial organism.


name: Grade 4 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Metastatic Malignant Digestive System Neoplasm

description: A malignant neoplasm that arises in the digestive system and has spread from its original site of growth to other anatomic sites.


name: Stage IV Pancreatic Cancer AJCC v6 and v7

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


7/8 HLA Match

description: Degree of HLA Match is 7/8 alleles with a single HLA locus mismatch at HLA-A, -B, -C or DRB1.


Pleural Mesothelioma pN1 TNM Finding v7

description: Pleural mesothelioma with metastases in the ipsilateral bronchopulmonary or hilar lymph nodes. (from AJCC 7th Ed.)


name: Grade 2 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Recurrent Fallopian Tube Mucinous Adenocarcinoma

description: The reemergence of fallopian tube mucinous adenocarcinoma after a period of remission.


Bladder Granular Cell Tumor

description: A rare granular cell tumor arising from the bladder. Most tumors are benign.


Epididymal Cystadenoma

description: A benign cystadenoma that arises from the epididymis.


Anal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the anal canal.


Venous lake

description: A condition that is characterized by venous dilation, which presents as soft, compressible lesions.


name: Grade 1 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Juvenile Arthritis, Unspecified, Right Hand

description: Evidence of unspecified juvenile arthritis in the right hand.


name: Central Nervous System Neoplasms, Primary

description: A benign or malignant neoplasm that arises from the brain or the spinal cord.


Serum Calcitonin Level Increased

description: A laboratory test result indicating an increased concentration of calcitonin in the blood serum.


name: Grade 4 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Moderate Adverse Event

description: An experience that is alleviated with simple therapeutic treatments. The event impacts usual daily activities. Includes laboratory test alterations indicating injury, but without long-term risk.


pT4 TNM Finding

description: A pathologic primary tumor TNM finding. The definition of pT4 finding depends on the particular type of cancer that it refers to; for example, for breast cancer, pT4 finding is defined as follows: cancer with tumor of any size with direct extension to chest wall or skin, but only as described in pT4 sub-categories, in accordance with TNM guidelines; for cervical cancer, pT4 finding is defined as follows: cancer invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). (from AJCC 7th Ed.)


Cystic urethritis

description: A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells.


name: Type 1 Diabetes Mellitus with Mild Nonproliferative Diabetic Retinopathy without Macular Edema, Left Eye

description: Evidence of type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema in the left eye.


Eyelid Carcinoma cN2 TNM Finding v8

description: Eyelid carcinoma with metastasis in a single ipsilateral regional lymph node, measuring more than 3 cm in greatest dimension, or in bilateral or contralateral lymph nodes. (from AJCC 8th Ed.)


name: Diabetes Mellitus due to Underlying Condition with Moderate Non-Proliferative Diabetic Retinopathy with Macular Edema, Right Eye

description: Evidence of diabetes mellitus due to underlying condition with moderate non-proliferative diabetic retinopathy with macular edema in the right eye.


name: Pancreatic Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v8

description: A clinical finding about one or more characteristics of a pancreatic neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


Peritoneal Infection, CTCAE

description: A disorder characterized by an infectious process involving the peritoneum.


name: Grade 1 Pulmonary Fibrosis Radiographic Changes, CTCAE


Other hydrocephalus

description: Evidence of other hydrocephalus not specified elsewhere.


CD20 Negative

description: An indication that CD20 expression has not been detected in a sample.


Substance Withdrawal Delirium

description: A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance withdrawal.


Grade 3 Infective Myositis, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 2 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Venous Angioleiomyoma

description: A morphologic variant of angioleiomyoma characterized by the presence of thick-walled veins.


name: Supraglottic Cancer pM1 TNM Finding v6 and v7

description: Supraglottic cancer with distant metastasis. (from AJCC 6th and 7th Eds.)


name: Grade 4 Hypoxic Ischemic Encephalopathy, AE

description: An adverse event in a newborn characterized by severe clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event with life-threatening consequences (e.g. respiratory depression, refractory seizures).


Malignant neoplasm musculoskeletal

description: A primary or metastatic malignant neoplasm that affects muscles and bones.


name: Sacral Plexus Intra-Operative Injury, CTCAE


name: Burkitt's lymphoma of intra-abdominal lymph nodes

description: Evidence of Burkitt lymphoma in the intra-abdominal lymph nodes.


Gingival odontogenic cyst

description: An odontogenic cyst found in the alveolar mucosa. (WHO 2017)


name: Grade 1 Kidney Intra-Operative Injury, CTCAE


Optimal Morphologic Response

description: Hypo-attenuation of the metastases which may appear pseudocystic, perfectly homogeneous, and devoid of a recognizable peripheral rim.


Grade 4 Pancreatic Necrosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Childhood Benign Bone Neoplasm

description: A childhood neoplasm that arises from bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Congenital hydroureter

description: Dilatation of the ureter caused by obstruction of urine flow that is present at birth.


Vulval Infection

description: An infectious process affecting the vulva. Causative agents include human papillomavirus, herpes virus, Trichomonas, and Candida. Symptoms include itching and pain in the genital area and discharge.


name: Adult Lymphocyte-Rich Classical Hodgkin Lymphoma

description: Lymphocyte-rich classic Hodgkin lymphoma that occurs in adults.


name: Mycosis Fungoides and Sezary Syndrome N1 TNM Finding v8

description: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. Note: EORTC N1 classification includes: Dutch grade 1: dermatopathic lymphadenopathy. NCI LN0: no atypical lymphocytes. NCI LN1: occasional and isolated atypical lymphocytes (not arranged in clusters). NCI LN2: many atypical lymphocytes or lymphocytes in 3-6 cell clusters. (from AJCC 8th Ed.)


Cervical Cancer cT3a TNM Finding v7

description: Cervical cancer involves lower third of vagina, without extension to pelvic wall. (from AJCC 7th Ed.)


Merkel Cell Carcinoma TNM Finding v7

description: A finding about one or more characteristics of Merkel cell carcinoma, following the rules of the TNM AJCC v7 classification system.  (from AJCC 7th Ed.)


Grade 4 Bladder Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Forced Expiratory Volume Decreased, CTCAE


Conjunctival Compound Nevus

description: A compound nevus that arises from the conjunctiva. It usually occurs in the bulbar conjunctiva, caruncle, and plica semilunaris. It is characterized by the presence of nevus cells within the epithelium and in the substantia propria. Type A nevus cells are present in the junctional nests and superficial substantia propria, and type B nevus cells are present in the deeper layers of the subepithelial compartment.


name: Negative Bone Marrow and Peripheral Blood


Grade 3 Hyperlipidemia, CTCAE

description: Hospitalization; pancreatitis


Grade 5 Ascites, CTCAE

description: Death


Intermittent Sun Exposure

description: Non-continuous exposure to sunlight.


name: Grade 2 Nasopharynx Intra-Operative Injury, CTCAE


Troublesome Pain

description: A sensation of discomfort or distress that worries an individual or interrupts their ability to complete desired activities.


Childhood Acute Myelomonocytic Leukemia

description: An acute myelomonocytic leukemia occurring in children.


Telangiectasia, CTCAE 5.0

description: A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.


name: Pneumococcal arthritis and polyarthritis


Third degree perineal laceration

description: Injury to perineum involving anal sphincter complex. (adapted from reVITALize)


name: Other Rheumatoid Arthritis with Rheumatoid Factor of Unspecified Hand

description: Evidence of other rheumatoid arthritis with rheumatoid factor of unspecified hand not specified elsewhere.


Aggressive osteoblastoma

description: An osteoblastoma characterized by the presence of prominent epithelioid osteoblasts and recurrences.


name: Upper Airway NOS Intra-Operative Injury, CTCAE


Helical Interpolation Artifact

description: A shape distortion in the z-axis resulting from the weighting function used in the helical interpolation algorithm.


Grade 2 Device Related Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal)


name: Advanced Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Sebaceous cell carcinoma of skin of left lower eyelid, including canthus

description: Evidence of sebaceous cell carcinoma of skin of left lower eyelid including the canthus.


name: Unspecified Pre-Existing Hypertension Complicating Pregnancy, First Trimester

description: Evidence of unspecified pre-existing hypertension complicating pregnancy in the first trimester.


Childhood Benign Neoplasm

description: A neoplasm that occurs during childhood and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Leiomyosarcoma and Endometrial Stromal Sarcoma pT2a TNM Finding v7

description: Tumor involves adnexa. (from AJCC 7th Ed.)


Jejunal Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum.


Refractory Malignant Brain Neoplasm

description: A malignant brain neoplasm that is resistant to treatment.


Virologic Failure

description: A finding of viremia at or after end of planned or actual treatment, excluding treatment discontinuations for non-virologic reasons.


Grade 1 Seroma, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IB Bone Sarcoma AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Rheumatoid Polyneuropathy with Rheumatoid Arthritis of Right Elbow

description: Evidence of rheumatoid polyneuropathy with rheumatoid arthritis of right elbow.


Laryngopharyngeal Dysesthesia, CTCAE

description: A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.


name: Invasive Ureter Urothelial Carcinoma with Glandular Differentiation

description: An invasive urothelial carcinoma of the ureter that exhibits glandular differentiation.


Biochemical Evidence of Disease

description: An indication that biochemical markers of a disease are present.


name: Rheumatoid Arthritis without Rheumatoid Factor, Left Wrist

description: Evidence of rheumatoid arthritis without rheumatoid factor in the left wrist.


name: Grade 1 Spermatic Cord Perforation, CTCAE


Grade 3 Perforation Bile Duct, CTCAE

description: Invasive intervention indicated


name: Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement

description: An acute lymphoblastic leukemia with rearrangement of the KMT2A gene that occurs in infancy.


Multicystic mesothelioma, benign

description: A mesothelial neoplasm that arises from the peritoneum and rarely the pleura. It is characterized by the presence of multiple cysts lined by flattened or cuboidal mesothelial cells. There is no evidence of significant cytologic atypia or increased mitotic activity. It may reoccur. Rare cases of transformation to malignant mesothelioma have been reported.


name: Hematologic Neoplasm with Germline ETV6 Mutation

description: Autosomal dominant familial thrombocytopenia associated with germline ETV6 mutation and hematologic malignancies. The hematologic malignancies reported are diverse, including myelodysplastic syndrome, acute myeloid leukemia, chronic myelomonocytic leukemia, B lymphoblastic leukemia, and plasma cell myeloma. Non-hematological neoplasms, including colorectal adenocarcinoma, have been also reported in affected families. (WHO 2017)


supravesical fissure of urinary bladder

description: A urogenital anomaly characterized by infraumbilical exstrophy of a bladder open only in its upper portion and pubic diastasis.  It has been described in both males and females and may be associated with trisomy 18, omphalocele, and urethral duplication.


name: Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Pulmonary Vein Intra-Operative Injury, CTCAE


name: Grade 1 Cranial Nerve XII Neuropathy, CTCAE


Vaginal Discharge, CTCAE

description: A disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years.


name: Thrombosis or Embolism Vascular Access Related, CTCAE


Lymphangitis carcinomatosa

description: Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination.  The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma.


name: Prostate Cancer Clinical Distant Metastasis TNM Finding v7

description: A clinical finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.


Grade 5 Small Intestine Ulcer, CTCAE

description: Death


name: Mycosis Fungoides and Sezary Syndrome T4 TNM Finding v8

description: Confluence of erythema covering 80% or more of body surface area. (from AJCC 8th Ed.)


name: Grade 3 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 3 Lower Extremity Artery Intra-Operative Injury, CTCAE


name: Intratubular large cell hyalinizing Sertoli cell neoplasia

description: A clinically benign intratubular neoplastic proliferation of large Sertoli cells in the testis. It is associated with prominent basement membrane deposits. It occurs almost exclusively in patients with Peutz-Jeghers syndrome.


Anal Cancer pM0 TNM Finding

description: Anal cancer with no evidence of distant metastasis. (from AJCC 6th Ed.)


name: Appendiceal Carcinoma pT1 TNM Finding v7

description: Appendiceal carcinoma with tumor invading submucosa. (from AJCC 7th Ed.)


name: Grade 5 Urinary Tract Obstruction, CTCAE

description: Death


Grade 2 Hematuria, CTCAE

description: Symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL


Cervical Cancer pT1b2 TNM Finding v8

description: Cervical cancer with clinically visible lesion more than 4.0 cm in greatest dimension. (from AJCC 8th Ed.)


Voiding Disorders

description: A group of conditions comprising dysfunction of the storage and elimination of urine.


HIV-Related Thrombocytopenia

description: Thrombocytopenia that occurs in patients with acquired immunodeficiency syndrome.


name: Grade 4 Mediastinum Intra-Operative Injury, CTCAE


name: Esophagus and Esophagogastric Junction Cancer pT3 TNM Finding v7

description: Esophagus and esophagogastric junction cancer with tumor invading adventitia. (from AJCC 7th Ed.)


name: Oropharyngeal Cancer Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of oropharyngeal cancer, following the rules of the TNM AJCC v7 classification system.  The pathologic staging requires the use of all information obtained in clinical staging and in histologic study of the surgically resected specimens.  (from AJCC 7th Ed.)


name: Mucosal Melanoma of the Head and Neck Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of mucosal melanoma of the head and neck, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Atherosclerosis of Autologous Vein Bypass Graft(s) of the Extremities with Intermittent Claudication, Unspecified Extremity

description: Evidence of atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication in an unspecified extremity.


Alcohol Intolerance, CTCAE

description: A disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches.


name: HPV-Mediated (p16-Positive) Oropharyngeal Cancer cM1 TNM Finding v8

description: HPV-mediated (p16-positive) oropharyngeal cancer with distant metastasis. (from AJCC 8th Ed.)


name: Other Thyrotoxicosis without Thyrotoxic Crisis or Storm

description: Evidence of other thyrotoxicosis without thyrotoxic crisis or storm not specified elsewhere.


Grade 1 Duodenal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Spongioneuroblastoma

description: A neuroectodermal tumor composed of neoplastic neural elements.


Caput succedaneum

description: A diffuse swelling of the scalp in a newborn, usually caused by the trauma of the scalp pushing through a narrowed cervix during birth. The swelling may extend across the midline of the scalp and may exhibit discoloration or bruising.


name: Grade 4 Restrictive Cardiomyopathy, CTCAE

description: Refractory heart failure or other poorly controlled cardiac symptoms


Bulky Lesion

description: A single lesion in bulky nodal disease.


Grade 2 Eyelid Function Disorder, CTCAE

description: Symptomatic; nonoperative intervention indicated; limiting instrumental ADL


Cyst of hydatid of Morgagni

description: A cystic structure located between the ovary and fallopian tube.


Hypertensive emergency

description: Hypertensive crisis with acute or ongoing end-organ damage.


name: Stage IV Gestational Trophoblastic Tumor AJCC v7

description: Stage IV includes: (Any T, M1b, Risk factors: unknown); IVA (Any T, M1b, Risk factors: low risk); IVB (Any T, M1b, Risk factors: high risk).  M1b: All other distant metastasis.  (AJCC 7th ed.)


EML4/ALK Fusion Negative

description: Indicates that expression of the EML4/ALK fusion has not been detected in a sample.


name: Other specified malignant neoplasms of lymphoid, hematopoietic and related tissue

description: Evidence of other specified malignant neoplasms of lymphoid, hematopoietic and related tissue not specified elsewhere.


name: Nasopharyngeal Cancer Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of nasopharyngeal cancer, following the rules of the TNM AJCC v7 classification system.  The pathologic staging requires the use of all information obtained in clinical staging and in histologic study of the surgically resected specimens.  (from AJCC 7th Ed.)


Adenosarcoma pT1b TNM Finding v7

description: Tumor invades to less than half of the myometrium. (from AJCC 7th Ed.)


name: Inferior Vena Cava Intra-Operative Injury, CTCAE


Complete Response in Aplastic Anemia

description: A hematologic response to treatment for aplastic anemia that meets the criteria of normal hemoglobin level for age, absolute neutrophil count, and platelet count.


name: Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8

description: Stage IA includes: (T1a, N0, M0, G1); (T1a, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. (AJCC 8th ed.)


name: Grade 2 Pancreatic Endocrine Glucose Intolerance, CTCAE


name: Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs cM1 TNM Finding v8

description: Soft tissue sarcoma of the abdomen and thoracic visceral organs with distant metastases. (from AJCC 8th Ed.)


Cutaneous Melanoma cN3 TNM Finding v7

description: Cutaneous melanoma with 1 or more metastatic nodes with in transit met(s)/satellite(s). (from AJCC 7th Ed.)


name: Peripheral T-Cell Lymphoma, not Classified, Lymph Nodes of Head, Face, and Neck

description: Evidence of unclassified peripheral T-cell lymphoma in the lymph nodes of the head in the face in the and neck.


Cervical Cancer pT1a TNM Finding v9

description: Invasive cervical carcinoma that can be diagnosed only by microscopy with maximum depth of invasion equal or less than 5 mm. (from AJCC 9th Ed.)


Grade 2 Urinary Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Estrogen Receptor Status

description: The estrogen receptor level measured in a primary tumor or in metastases.  There are essentially two distinct forms of breast cancer, one that tends to have an early onset and is characterized by an ER- status, and one that tends to have a late onset and is characterized by an ER+ status.  However, these two variants tend to overlap with respect to age, so it is possible for a young woman to have a "late-onset" form of breast cancer and for an older woman to have an "early-onset" variant of the disease.


name: Grade 1 Herpes Simplex Reactivation, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Post-biopsy Pain

description: A sensation of discomfort secondary to sampling of tissue or bodily fluid.


name: Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Myocardial Edema by T2 Mapping or T2-weighted Imaging

description: Regional or global myocardial increase in signal intensity on T2-weighted images suggestive of edema.


Childhood Giant Cell Tumor of Bone

description: A giant cell tumor of bone that occurs during childhood.


name: Differentiated vulvar intraepithelial neoplasia

description: HPV-negative vulvar squamous intraepithelial proliferation characterized by atypia of the basal and parabasal keratinocytes in an otherwise well-differentiated epithelium. Despite its subtle appearance, it has a high risk of malignant transformation. (WHO 2020)


name: Small Intestine Cancer cM0 TNM Finding v7

description: Small intestine cancer without evidence of distant metastasis. (from AJCC 7th Ed.)


Breast Cancer pT4 TNM Finding v6 and v7

description: Breast cancer with tumor of any size with direct extension to chest wall or skin, but only as described in pT4 sub-categories, in accordance with TNM guidelines. (from AJCC 6th and 7th Eds.)


name: Stage II Contiguous Adult Diffuse Large Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Other non-follicular lymphoma, lymph nodes of inguinal region and lower limb

description: Evidence of other non-follicular lymphoma in the lymph nodes of inguinal region and lower limb not specified elsewhere.


name: Grade 2 Peritoneal Cavity Hemorrhage, CTCAE


Gallbladder Hyperplastic Polyp

description: A polypoid tumor that arises from the gallbladder.  It is characterized by the presence of elongated, serrated crypts lined by proliferative epithelium.


name: Grade 1 Intraoperative Neurological Injury, CTCAE

description: Primary repair of injured organ/structure indicated


CD79A Negative

description: An indication that CD79A expression has not been detected in a sample.


name: Hernia of unspecified site without mention of obstruction or gangrene

description: The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, without mention of obstruction or necrosis of the herniated contents.


Stage IB2 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma equal or more than 2 cm and less than 4 cm in greatest dimension. (FIGO 2018)


name: Ductal carcinoma in situ of right breast

description: Evidence of intraductal carcinoma in situ of right breast.


name: Chronic or unspecified peptic ulcer of unspecified site with haemorrhage

description: Evidence of chronic or unspecified peptic ulcer, site unspecified, with hemorrhage.


T1 TNM Finding

description: A clinical and/or pathologic primary tumor TNM finding indicating that the cancer is limited to the site of growth.


Absence of MYCN Gene Amplification

description: A molecular finding indicating the absence of multiple copies of the MYCN gene in a tissue sample.


Labile affect

description: Emotional instability characterized by rapid and dramatic mood swings. (ACC/AHA)


Body Mass Index 33.0-33.9, Adult

description: Evidence of a body mass index of 33.0-33.9 in the adult.


name: Anemia Complicating Pregnancy, Third Trimester

description: Evidence of anemia complicating pregnancy in the third trimester.


name: Post-Immunization Arthropathy, Unspecified Knee

description: Evidence of post-immunization arthropathy in an unspecified knee.


Combined Nevus

description: A nevus that contains two or more melanocytic nevus components in the same lesion. The cellular components can be any combination of any nevus variants, but most frequently, a common nevus component is combined with a blue nevus, deep penetrating nevus, or Spitz nevus component. (WHO 2018)


name: Grade 2 Larynx Obstruction and Stenosis, CTCAE


Luminal A Prostate Carcinoma

description: Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a lower proliferation score than the luminal B and basal-like prostate carcinomas.


Pancreatic Medullary Carcinoma

description: A pancreatic ductal adenocarcinoma characterized by poor differentiation and a prominent syncytial growth pattern.  The prognosis is more favorable compared to conventional pancreatic ductal adenocarcinoma.


name: Small Intestine Cancer pTX TNM Finding v8

description: Small intestine cancer in which the primary tumor cannot be assessed. (from AJCC 8th Ed.)


name: Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs pT4 TNM Finding v8

description: Soft tissue sarcoma of the abdomen and thoracic visceral organs with multifocal involvement. (from AJCC 8th Ed.)


name: Sudden Death Not Associated with More Specific CTCAE Term, CTCAE


PSA Level 0.5 to Ten

description: A blood concentration of prostate specific antigen between 0.5 and 10 ng/mL.


Chemosensitivity

description: Sensitivity of a malignancy to administration of chemotherapy, usually defined as the achievement of a partial response or better.


name: Monoplegia of Upper Limb following Non-Traumatic Intracerebral Hemorrhage Affecting Left Dominant Side

description: Evidence of monoplegia of upper limb following non-traumatic intracerebral hemorrhage affecting left dominant side.


name: Refractory Urethral Urothelial Carcinoma

description: Urethral urothelial carcinoma that is resistant to treatment.


Acute perforated appendicitis

description: Acute appendicitis with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


name: Right Anterior Middle Peripheral Zone of Prostate

description: The region of the prostate that is located on the anatomical right side of the anterior portion of the middle division of the peripheral zone.


name: Malignant Neoplasm of Axillary Tail of Left Male Breast

description: Evidence of a malignant neoplasm of the axillary tail of left male breast.


name: Other Disease of Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism Complicating Pregnancy, Unspecified Trimester

description: Evidence of other disease of blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy in an unspecified trimester not specified elsewhere.


name: Childhood Hematopoietic and Lymphoid Cell Neoplasm

description: A neoplasm of hematopoietic and lymphoid cell origin that occurs during childhood. Representative examples include acute leukemias and lymphomas.


Weight Gain, CTCAE

description: A finding characterized by an unexpected or abnormal increase in overall body weight; for pediatrics, greater than the baseline growth curve.


name: Hepatocellular Carcinoma pT1a TNM Finding v8

description: Hepatocellular carcinoma with solitary tumor equal to or less than 2 cm. (from AJCC 8th Ed.)


Grade 4 Esophageal Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Melanoma of the Conjunctiva Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of melanoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Carcinoma of the Conjunctiva pT1 TNM Finding v7

description: Carcinoma of the conjunctiva with tumor measuring 5 mm or less in greatest dimension.  Note: tumors occur most commonly in the bulbar limbal conjunctiva. (from AJCC 7th Ed.)


Grade 5 Urostomy Obstruction, CTCAE

description: Death


name: Pre-Existing Hypertensive Heart Disease Complicating Pregnancy, First Trimester

description: Evidence of pre-existing hypertensive heart disease complicating pregnancy in the first trimester.


name: Refractory Acute Graft Versus Host Disease

description: Acute graft versus host disease that is resistant to treatment.


Grade 4 Constipation, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Adrenal Cancer Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of adrenal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for adrenal cancer. (from AJCC 7th Ed.)


Estrogen Receptor Status 0

description: An immunohistochemical result of 0 for estrogen receptor expression that is considered negative for expression.


name: Melanoma in Situ of Unspecified Lower Limb, Including Hip

description: Evidence of melanoma in situ of unspecified lower limb including the hip.


Colorectal Cancer pM1a TNM Finding v8

description: Colorectal cancer with metastasis to one site or organ without peritoneal metastasis. (from AJCC 8th Ed.)


description: Evidence of cocaine dependence with cocaine-induced sleep disorder.


Tumor Greater than or Equal to 2.1 cm

description: A tumor where the greatest dimension is greater than or equal to 2.1 cm.


Injury of upper respiratory tract

description: Mechanical or chemical injuries to the upper airways, including trachea, pharynx and larynx.


Childhood Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma that arises from the central nervous system and occurs during childhood.


CNS metastases

description: A malignant neoplasm that has spread to the central nervous system from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


Refractory Uterine Corpus Cancer

description: Uterine corpus cancer that is resistant to treatment.


name: Other infective spondylopathies, multiple sites in spine

description: Evidence of other infective spondylopathies in multiple sites in spine not specified elsewhere.


Grade 3 Anal Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated


name: Grade 3 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IVA Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to adjacent pelvic organs. (FIGO 2018)


name: Grade 1 Ileum Stricture or Stenosis, CTCAE


Decerebrate Posture

description: A posture characterized body rigidity and by extension of the neck, arms, and legs. It may indicate brain stem damage and may suggest herniation of the brain.


name: Grade 2 Rash Hand or Foot Skin Reaction, CTCAE


name: Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Bone Cancer pT2 TNM Finding v7

description: Bone cancer with tumor measuring more than 8 cm in greatest dimension. (from AJCC 7th Ed.)


Anal Cancer Clinical TNM Finding v8

description: A clinical finding about one or more characteristics of anal cancer, following the rules of the TNM AJCC v8 classification system.


Bronchospasm, CTCAE

description: A disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall.


MKI67 Negative

description: An indication that MKI67 expression has been detected in a sample.


description: Evidence of sedative, hypnotic or anxiolytic abuse with withdrawal delirium.


name: Major Salivary Gland Cancer Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of major salivary gland cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.


name: Grade 3 Nasal Cavity Intra-Operative Injury, CTCAE


name: Grade 3 Parathyroid Intra-Operative Injury, CTCAE


Grade 3 Rectal Fistula, CTCAE

description: Invasive intervention indicated


name: Sedative, Hypnotic or Anxiolytic Induced Dependence with Sexual Dysfunction

description: Evidence of sedative, hypnotic or anxiolytic induced dependence with sexual dysfunction.


name: Unresectable Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that is not amenable to surgical resection.


Dystonia 11, Myoclonic

description: An autosomal dominant condition caused by mutation(s) in the SGCE gene, encoding epsilon-sarcoglycan. It is characterized by myoclonus of the proximal muscles and dystonia.


Complication of transplanted liver

description: A disease or disorder that is associated with a transplanted liver.


Incontinent Epispadias

description: Epispadias with urinary incontinence.


name: Acute Myeloid Leukemia with a Variant KMT2A Rearrangement

description: A term referring to acute myeloid leukemias with rearrangement of the KMT2A gene that results in translocations with various genes other than the MLLT3 (AF9) gene.


Adenosarcoma cM1 TNM Finding v7

description: Distant metastasis (excluding adnexa, pelvic and abdominal tissues). (from AJCC 7th Ed.)


Grade 4 Encephalitis Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Anal Cancer Pathologic Regional Lymph Nodes TNM Finding v6

description: A pathologic finding about one or more characteristics of anal cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of regional lymph nodes.


Chylous Ascites, CTCAE

description: A disorder characterized by accumulation of milky fluid in the peritoneal cavity.


name: Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Obesity Complicating Pregnancy, Second Trimester

description: Evidence of obesity complicating pregnancy in the second trimester.


Grade 1 Erythema Multiforme, CTCAE

description: Target lesions covering <10% BSA and not associated with skin tenderness


name: Esophagus and Esophagogastric Junction Cancer pM1 TNM Finding v7

description: Esophagus and esophagogastric junction cancer with distant metastasis. (from AJCC 7th Ed.)


Shock from electric current

description: A brief, unintentional exposure to an electric current, which may result in local tissue damage due to thermal injury or in a cardiac dysrhythmia.


ESR2 Status

description: Refers to the presence or absence of ESR2 in a sample.


name: Gestational Diabetes Mellitus in Childbirth, Unspecified Control

description: Evidence of gestational diabetes mellitus in childbirth with unspecified control.


name: Gestational Trophoblastic Tumor by AJCC v7 Stage

description: A term that refers to the staging of gestational trophoblastic tumor according to the American Joint Committee on Cancer, 7th edition.


name: Grade 4 Urinary Tract NOS Intra-Operative Injury, CTCAE


name: Other Specified Diabetes Mellitus with Moderate Nonproliferative Diabetic Retinopathy without Macular Edema, Right Eye

description: Evidence of other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema in the right eye not specified elsewhere.


name: Glottic Cancer pN1 TNM Finding v6 and v7

description: Glottic cancer with metastasis to a single ipsilateral lymph node, 3 cm or less in greatest dimension. (from AJCC 6th and 7th Eds.)


Retinoblastoma cT0 TNM Finding v7

description: Retinoblastoma with no evidence of a primary tumor. (from AJCC 7th Ed.)


name: Grade 4 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


CCND1/IGH Fusion Negative

description: An indication that CCND1/IGH fusion expression has not been detected in a sample.


name: Grade 2 Intraoperative Respiratory Injury, CTCAE

description: Partial resection of injured organ/structure indicated


name: Type 2 Diabetes Mellitus with Unspecified Diabetic Retinopathy with Macular Edema

description: Evidence of type 2 diabetes mellitus with unspecified diabetic retinopathy with macular edema.


Sinus Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.


name: hallucinogen dependence with intoxication - uncomplicated

description: Evidence of hallucinogen dependence with intoxication, uncomplicated.


Clinically Significant Anxiety Symptoms

description: An indication that an individual's anxiety symptoms are or were clinically significant.


name: Nasal Cavity and Ethmoid Sinus Cancer pN3 TNM Finding v6 and v7

description: Nasal cavity and ethmoid sinus cancer with metastasis in a lymph node, more than 6 cm in greatest dimension. (from AJCC 6th and 7th Eds.)


name: Other Malignant Neoplasm Skin of Left Eyelid, Including Canthus

description: Evidence of other malignant neoplasm skin of the left eyelid including the canthus not specified elsewhere.


name: Grade 3 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Superficial Thrombophlebitis, CTCAE

description: A disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities.


Hypoalbuminemia, CTCAE

description: A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.


HLA-A*0201 Negative

description: An indication that cells expressing HLA-A*0201 have not been detected in a tissue sample.


name: Alcohol Use Complicating Pregnancy, Second Trimester

description: Evidence of alcohol use complicating pregnancy in the second trimester.


name: Grade 2 Pulmonary Vein Intra-Operative Injury, CTCAE


name: Mycosis Fungoides and Sezary Syndrome N1a TNM Finding v7

description: Clone negative.  Note: A T-cell clone is defined by PCR or Southern blot analysis of the T-cell receptor gene.  (from AJCC 7th Ed.)


Metastatic malignant neoplasm to kidney

description: The spread of a malignant neoplasm to the kidney.  This may be from a primary kidney malignant neoplasm involving the opposite kidney, or from a malignant neoplasm at a distant site.


name: Lip and Oral Cavity Cancer pN2c TNM Finding v8

description: Lip and oral cavity cancer with metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Hemoglobin Alpha trans-Deletion Genotype

description: A genetic finding indicating that both copies of chromosome 16 each have only one functional hemoglobin alpha (HBA) gene. This genotype is associated with the alpha thalassemia trait.


name: Grade 2 Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Grade 3 Dental Caries, CTCAE

description: Dental caries resulting in pulpitis or periapical abscess or resulting in tooth loss


Grade 1 Ventricular Arrhythmia, CTCAE

description: Asymptomatic, intervention not indicated


name: Uveal Melanoma Pathologic Distant Metastasis TNM Finding v8

description: A pathologic finding about one or more characteristics of uveal melanoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Other Specified Diabetes Mellitus with Severe Nonproliferative Diabetic Retinopathy without Macular Edema, Right Eye

description: Evidence of other specified diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema in the right eye not specified elsewhere.


name: Grade 5 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Rheumatoid Heart Disease with Rheumatoid Arthritis of Right Shoulder

description: Evidence of rheumatoid heart disease with rheumatoid arthritis of right shoulder.


name: Grade 3 Epstein-Barr Virus Infection Reactivation, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


Increased Secretion

description: Increased amount of a secretory content present in the glandular lumen.


Gastrointestinal Carcinomatosis

description: Carcinoma that has spread diffusely to the gastrointestinal system.


name: Allergic contact dermatitis caused by Arnica

description: Dermatitis caused by an allergic reaction to arnica.


name: Other Atherosclerosis of Autologous Vein Bypass Graft(s) of the Extremities, Unspecified Extremity

description: Evidence of other atherosclerosis of autologous vein bypass graft(s) of the extremities, unspecified extremity not specified elsewhere.


name: Grade 4 Fallopian Tube Perforation, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated (e.g., organ resection)


name: Other Musculoskeletal and Soft Tissue, CTCAE


name: Indolent T-cell lymphoproliferative disorder of gastrointestinal tract

description: A clonal T-cell lymphoproliferative disorder that can involve the mucosa in all sites of the gastrointestinal tract, but is most common in the small intestine and colon. The lymphoid cells infiltrate the lamina propria but usually do not show invasion of the epithelium. The clinical course is indolent, but most patients do not respond to conventional chemotherapy. A subset of cases progress to a higher-grade T-cell lymphoma with spread beyond the gastrointestinal tract. (WHO 2017)


Adrenal Cancer pT1 TNM Finding v7

description: Adrenal cancer with tumor measuring 5 cm or less in greatest dimension, without extra-adrenal invasion. (from AJCC 7th Ed.)


Brain Low Grade Glioma

description: A low-grade glioma that arises from the brain.


Grade 1 Fracture, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Acute Myeloid Leukemia with BCOR Mutation

description: An acute myeloid leukemia associated with BCOR gene mutation.


name: Advanced Malignant Genitourinary System Neoplasm

description: A malignant genitourinary neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refluxing Obstructed Megaureter

description: A megaureter in which there is retrograde flow of urine and a concomitant, episodic obstruction resulting from ureteral folding.


name: Hypopharyngeal Cancer pN2c TNM Finding v8

description: Hypopharyngeal cancer with metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Soft Tissue Sarcoma of the Head and Neck pN1 TNM Finding v8

description: Soft tissue sarcoma of the head and neck with regional lymph node metastasis. (from AJCC 8th Ed.)


Uterine Corpus Germ Cell Tumor

description: A benign or malignant germ cell tumor that arises from the uterine corpus. Representative examples include teratoma and yolk sac tumor.


Enterocolitis Infectious, CTCAE

description: A disorder characterized by an infectious process involving the small and large intestines.


name: Postneoadjuvant Therapy Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Melanoma of the Uvea Clinical TNM Finding v7

description: A clinical finding about one or more characteristics of melanoma of the uvea, following the rules of the TNM AJCC v7 classification system.


name: Prostate Adenocarcinoma by AJCC v7 Stage

description: A term that refers to the staging of prostate adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Non-Neoplastic Appendix Disorder

description: A non-neoplastic disorder that affects the appendix.


name: Grade 4 Testis Intra-Operative Injury, CTCAE


name: Grade 3 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma pN1a TNM Finding v8

description: Ovarian, fallopian tube, or primary peritoneal carcinoma with metastasis up to 10 mm in greatest dimension. (from AJCC 8th Ed.)


name: Colorectal Neuroendocrine Tumor pM1 TNM Finding v8

description: Colorectal neuroendocrine tumor with distant metastasis. (from AJCC 8th Ed.)


Malignant neoplasm of isthmus uteri

description: Evidence of a malignant neoplasm of the isthmus uteri.


name: Appendix Neuroendocrine Tumor pT3 TNM Finding v8

description: Appendix neuroendocrine tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. (from AJCC 8th Ed.)


description: Evidence of cannabis abuse with psychotic disorder with delusions.


name: Unspecified inflammatory spondylopathy, site unspecified

description: Evidence of unspecified inflammatory spondylopathy in the site unspecified.


Grade 1 Skin Hyperpigmentation, CTCAE

description: Hyperpigmentation covering <10% BSA; no psychosocial impact


name: Lymphoproliferative Disorder of the Skin

description: A lymphoproliferative disorder that affects the skin.


Cytomegalovirus Negative

description: Indicates that cytomegalovirus has not been detected in a sample.


name: Supraglottic Cancer Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of supraglottic cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.  Metastases at level VII are considered regional lymph node metastases. (from AJCC 7th Ed.)


Diffuse Astrocytoma, MYB-Altered

description: A rare IDH-and H3-wildtype diffuse astrocytoma characterized by the presence of a monomorphic population of neoplastic cells that exhibit alteration in the MYB gene. This alteration is associated with fusion between MYB gene and a partner gene, usually PCDHGA1, MMP16, and MAML2 genes.


Tooth Discoloration, CTCAE

description: A disorder characterized by a change in tooth hue or tint.


Encephalomyelitis Infection, CTCAE

description: A disorder characterized by an infectious process involving the brain and spinal cord tissues.


Right Ventricular Dysfunction, CTCAE

description: A disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall.


Benign Intracranial Meningioma

description: A grade I, slowly growing meningioma within the cranial cavity.


DNA Damage Response Deficiency Negative

description: An indication that genetic markers for DNA damage response deficiency were not detected in a sample.


Gallbladder Cancer pT1b TNM Finding v8

description: Gallbladder cancer with tumor invading the muscular layer. (from AJCC 8th Ed.)


name: Mucosal Melanoma of the Head and Neck pM1 TNM Finding v7

description: Mucosal melanoma of the head and neck with distant metastasis. (from AJCC 7th Ed.)


name: Grade 3 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Fever Without Neutropenia, CTCAE


name: Isolated Non-Pigmented Micronodular Adrenal Hyperplasia

description: A subtype of micronodular adrenal hyperplasia, characterized by multiple non-pigmented nodules.


name: Esophagus and Esophagogastric Junction Cancer pNX TNM Finding v8

description: Esophagus and esophagogastric junction cancer in which the regional lymph nodes cannot be assessed.  (from AJCC 8th Ed.)


name: Uterine Corpus Adenosarcoma Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of uterine corpus adenosarcoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor. The definitions of the T categories correspond to the stages accepted by FIGO. (from AJCC 8th Ed.)


Lung Lesion

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of the lung.


name: Metastatic Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site.