Lung Squamous Cell Carcinoma In Situ

description: A preinvasive bronchial neoplastic lesion affecting the squamous epithelium. It is characterized by the absence of progression of maturation from base to luminal surface, basilar zone expansion with cellular crowding throughout the epithelium, absence of the intermediate zone, and surface flattening confined to the most superficial cells. The nuclear-to-cytoplasmic ratio is often high and variable, the chromatin is coarse and uneven, and mitotic figures are present through full thickness. The cell size may be markedly increased. Anisocytosis and pleomorphism may be present. (Adapted from WHO, 2015)


Recurrent Mediastinal Lymphoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The reemergence of a mediastinal lymphoma after a period of remission.


Stage IIA Lung Adenocarcinoma AJCC v7

description: Stage IIA includes: (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


name: Minimally Invasive Lung Mucinous Adenocarcinoma

description: A morphologic variant of minimally invasive lung adenocarcinoma characterized by tall columnar cells and mucin production.


Metastatic Lung Adenocarcinoma

description: Lung adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Pulmonary Mucinous Cystic Tumor of Borderline Malignancy

description: A very rare, non-invasive epithelial neoplasm that arises from the lung. It is composed of multilocular cysts filled with mucus. The cysts are lined with columnar mucinous epithelium. Focal cellular atypia is present.


Thymic Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from the thymus gland.  It is usually of the nodular sclerosis subtype and is often associated with cystic changes in the thymic epithelium.


name: Stage I Pleural Malignant Mesothelioma AJCC v7

description: Stage I includes: (T1, N0, M0); IA: (T1a, N0, M0); IB: (T1b, N0, M0).  T1: Pleural mesothelioma with a tumor limited to the ipsilateral parietal pleura with or without mediastinal pleura and with or without diaphragmatic pleural involvement. T1a: Pleural mesothelioma with no involvement of the visceral pleura. T1b: Pleural mesothelioma with a tumor also involving the visceral pleura N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


sternum lymphoma

description: A rare lymphoma that arises from the bone or soft tissue of the sternum.


Intrathyroidal Thymoma

description: A rare thymoma arising within or is attached to the thyroid gland.


name: Unresectable Lung Non-Squamous Non-Small Cell Carcinoma

description: Lung non-squamous non-small cell carcinoma that is not amenable to surgical resection.


name: Unresectable Lung Large Cell Neuroendocrine Carcinoma

description: Lung large cell neuroendocrine carcinoma that is not amenable to surgical resection.


name: Locally Advanced Lung Neuroendocrine Neoplasm

description: A lung neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Lung Small Cell Carcinoma Neuroendocrine Subtype

description: A header term that refers to the classification of lung small cell carcinoma based on the expression pattern of different neuroendocrine markers such as chromogranin A, synaptophysin, neural cell adhesion molecule 1, and gastrin-releasing peptide.


Pleural Leiomyosarcoma

description: A rare leiomyosarcoma that arises from the pleural cavity.


Ectopic Cervical Thymoma

description: A thymoma that arises in the cervical region and is not connected with the thymus gland.


name: keratinizing squamous cell carcinoma of lung

description: A squamous cell lung carcinoma characterized by the presence of keratinization, pearl formation, and/or intercellular bridges.


epicardium cancer

description: A malignant neoplasm involving the epicardium.


Masaoka-Koga Stage IV

description: The tumor shows metastasis throughout the pleural and/or pericardial spaces or metastasis to distant sites.


Lung Enteric Adenocarcinoma

description: A well-differentiated adenocarcinoma located in the lung periphery. It resembles colorectal adenocarcinoma with acinar and/or cribriform architecture and papillotubular structures.


name: Stage II Pleural Malignant Mesothelioma AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Pleural mesothelioma with a tumor involving each of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following: involvement of diaphragmatic muscle; extension of tumor from visceral pleura into the underlying pulmonary parenchyma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Pleural Monophasic Synovial Sarcoma

description: A monophasic synovial sarcoma arising in the pleural cavity.


Lung Monophasic Synovial Sarcoma

description: A monophasic synovial sarcoma arising from the lungs.


name: Stage IIIB Lung Small Cell Carcinoma AJCC v7

description: Stage IIIB includes: (T1a, N3, M0); (T1b, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N3, M0); (T4, N2, M0); (T4, N3, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  N3: Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Bronchiolar adenoma/ciliated muconodular papillary tumor

description: A rare, benign, circumscribed nodule arising from the bronchioles. It is usually seen in middle-aged to elderly patients. It is characterized by the presence a two-layer cellular structure composed of a basal and luminal layer.


Atypical Adenomatous Lung Hyperplasia

description: A preinvasive lesion in the lung. It is characterized by the presence of a small, localized proliferation of mildly to moderately atypical type II pneumocytes and/or Clara cells lining alveolar walls and sometimes respiratory bronchioles.


Sternal Intraosseous Schwannoma

description: A rare schwannoma that arises from the sternum.


Lung Melanoma

description: A rare malignant neoplasm that derives from melanocytes and arises from the lung in a patient with no history of previous melanoma and no evidence of melanoma in another site at the time of diagnosis.  It usually presents as a solitary lesion and the prognosis is poor.


Metastatic Lung Carcinoid Tumor

description: Lung neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Stage IV Lung Cancer AJCC v7

description: Stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b).  M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion.  M1b: Distant metastasis. (AJCC 7th ed.)


Thymic Typical Carcinoid Tumor

description: A primary thymic neuroendocrine tumor, characterized by the presence of uniform, polygonal neoplastic cells, a low mitotic rate, and absence of necrosis.


Stage 0 Lung Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. Squamous cell carcinoma in situ (SCIS). Adenocarcinoma in situ (AIS): adenocarcinoma with pure lepidic pattern, 3 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Intrapulmonary thymoma

description: An epithelial neoplasm that arises from ectopic thymic tissue in the lung.  Histologically it is identical to the thymomas that arise from the mediastinum.  Signs and symptoms include cough, dyspnea, fever, and weight loss.  Surgical excision is the recommended treatment.


name: childhood mediastinal neurogenic neoplasm

description: A peripheral nervous system neoplasm that arises in the mediastinum during childhood.


name: Metastatic Lung Non-Squamous Non-Small Cell Carcinoma

description: A non-squamous non-small cell carcinoma that arises from the lung and has metastasized to another anatomic site.


mediastinum sarcoma

description: A rare sarcoma that arises from the mediastinum. Examples include liposarcoma, leiomyosarcoma, and angiosarcoma.


Cardiac Schwannoma

description: A benign peripheral nervous system neoplasm that is composed of well-differentiated Schwann cells and affects the heart.


mediastinal extraskeletal osteosarcoma

description: An osteosarcoma arising from the mediastinum.


name: Stage IV Lung Squamous Cell Carcinoma AJCC v7


Ganglioneuroma of mediastinum

description: A ganglioneuroma arising from the mediastinum.


Thymic Atypical Carcinoid Tumor

description: A primary thymic neuroendocrine tumor characterized by a high mitotic rate, often associated with the presence of necrosis and nuclear pleomorphism. This type of neuroendocrine tumor has a more aggressive clinical course, compared to grade 1 neuroendocrine tumors.


Stage IIA Lung Cancer AJCC v7

description: Stage IIA includes: (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IIA Non-Small Cell Lung Carcinoma AJCC v7


Stage IB Lung Cancer AJCC v7

description: Stage IB includes: T2a, N0, M0.  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Locally Advanced Lung Carcinoma

description: A lung carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Thoracic NUT Carcinoma

description: A highly aggressive, poorly differentiated carcinoma that arises from the thoracic structures. It is characterized by mutations and rearrangement of the NUT gene. It usually presents at an advanced stage with pleuritic chest pain and pleural effusion, non-productive cough, shortness of breath, and weigh loss.


Chest Wall Sarcoma

description: A sarcoma that arises from the anatomic structures that surround the lungs and the pleura.


axillary neoplasm

description: A benign or malignant neoplasm that affects the structures of the axilla. Representative examples include axillary lipoma, axillary lymph node lymphoma, and metastatic carcinoma to the axillary lymph nodes.


name: Resectable Pleural Malignant Mesothelioma

description: Malignant mesothelioma of the pleura that is amenable to surgical resection.


Childhood Lung Neoplasm

description: A benign or malignant neoplasm that involves the lungs during childhood.


mediastinal malignant lymphoma

description: A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma.


Masaoka-Koga Stage I

description: The tumor is completely encapsulated.


Mediastinal Mature Teratoma

description: An extragonadal mature teratoma that arises from the mediastinum.  It is usually encapsulated and characterized by the presence of unilocular or multilocular cysts. The cysts can contain clear fluid, mucoid material, sebaceous debris, fat, hair, cartilage, and rarely teeth or bone.


Small cell lung cancer extensive stage

description: Small cell lung carcinoma which has spread beyond one hemi-thorax and the regional lymph nodes.


name: Lung Squamous Cell Carcinoma, Papillary Variant

description: A morphologic variant of squamous cell lung carcinoma characterized by the presence of papillary structures.


Advanced Lung Squamous Cell Carcinoma

description: Lung squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Oligometastatic Lung Carcinoma

description: Lung carcinoma that has metastasized to a limited number of sites.


name: Extramedullary Disease in Multiple Myeloma Involving the Lung

description: Infiltration of the lung by malignant (clonal) plasma cells in patients with history of multiple myeloma.


name: Chest Wall Plexiform Fibrohistiocytic Tumor

description: An intermediate fibrohistiocytic neoplasm arising from the skin in the chest wall. It is a multinodular poorly circumscribed tumor, characterized by the presence of multinucleated giant cells, mononuclear histiocyte-like cells, and spindle fibroblast-like cells arranged in a plexiform pattern.


name: Stage IIB Lung Small Cell Carcinoma AJCC v7

description: Stage IIB includes: (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


benign neoplasm of endocardium

description: A benign neoplasm that involves the endocardium.


Pleural Synovial Sarcoma

description: A synovial sarcoma arising in the pleural cavity.


malignant neoplasm of chest wall

description: A cancer that involves the chest wall.


name: Stage II Thymic Epithelial Neoplasm AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor with direct invasion of the pericardium (either partial or full thickness). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Early Stage Lung Non-Small Cell Carcinoma

description: A stage term that refers to lung non-small cell carcinoma stages I, II, and IIIA.


Lung Carcinoma Metastatic in the Liver

description: A carcinoma that originates from the lung and has spread to the liver.


name: Lung Squamous Cell Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of squamous cell lung carcinoma, following the rules of the TNM AJCC v7 classification system.


neoplasm of endocardium

description: A neoplasm (disease) that involves the endocardium.


name: EGFR-Positive Lung Non-Small Cell Carcinoma

description: Lung non-small cell carcinoma that is associated with EGFR gene mutation.


name: Locally Advanced Pleural Malignant Mesothelioma

description: Pleural malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Lung Carcinoid Tumor

description: Lung neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Platinum-Sensitive Lung Small Cell Carcinoma

description: Lung small cell carcinoma that is sensitive to platinum therapy.


Lepidic Predominant Adenocarcinoma

description: A lung adenocarcinoma characterized by the presence of mildly and moderately differentiated adenocarcinoma cells across the alveolar walls with at least one focus of invasive carcinoma measuring more than 5 mm in greatest dimension.


Stage IIA Lung Cancer AJCC v8

description: Stage IIA includes: T2b, N0, M0. T2b: Tumor measuring more than 4 cm but 5 cm or less in greatest dimension.  N0: No regional lymph node metastases. M0: No distant metastasis. (AJCC 8th ed.)


Glandular papilloma of lung

description: A benign papillary neoplasm that arises endobronchially.  It is characterized by the presence of fibrovascular cores lined by columnar, cuboidal, and goblet cells.  Patients usually present with signs and symptoms of bronchial obstruction.  Complete resection is curative.


name: Basaloid squamous cell carcinoma of lung

description: A morphologic variant of squamous cell lung carcinoma characterized by nuclear palisading.


Stage III Thymoma AJCC v8

description: Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0). T3: Tumor with direct invasion into any of the following: lung, brachiocephalic vein, superior vena cava, phrenic nerve, chest wall, or extrapericardial pulmonary artery or veins. T4: Tumor with invasion into any of the following: aorta (ascending, arch, or descending), arch vessels, intrapericardial pulmonary artery, myocardium, trachea, esophagus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Unresectable Thymic Carcinoma

description: A thymic carcinoma that is not amenable to surgical resection.


name: Stage IV Thymic Epithelial Neoplasm AJCC v8

description: Stage IV includes: IVA: (Any T, N1, M0); (Any T, N0,1, M1a); IVB: (Any T, N2, M0, M1a); (Any T, Any N, M1b). N0: No regional lymph node metastasis. N1: Metastasis in anterior (perithymic) lymph nodes. N2: Metastasis in deep intrathoracic or cervical lymph nodes. M0: No distant metastasis. M1a: Separate pleural or pericardial nodule(s). M1b: Pulmonary intraparenchymal nodule or distant organ metastasis. (AJCC 8th ed.)


Stage IV Lung Cancer AJCC v8

description: Stage IV includes: IVA: (Any T, Any N, M1a); (Any T, Any N, M1b); IVB: (Any T, Any N, M1c). M1a: Tumor with separate tumor nodule(s) in a contralateral lobe; tumor with pleural or pericardial nodules or malignant pleural or pericardial effusion. Most pleural (pericardial) effusions with lung cancer are a result of the tumor. In a few patients, however, multiple microscopic examinations of pleural (pericardial) fluid are negative for tumor, and the fluid is nonbloody and not an exudate. If these elements and clinical judgment dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging descriptor. M1b: Tumor with single extrathoracic metastasis in a single organ (including involvement of a single nonregional node). M1c: Tumor with multiple extrathoracic metastases in a single organ or in multiple organs. (AJCC 8th ed.)


name: Stage II Malignant Mediastinal Germ Cell Tumor

description: Locoregional tumor, non-metastatic, macroscopic complete resection but microscopic residual tumor. (WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart, 2015)


neoplasm of pericardium

description: A neoplasm (disease) that involves the pericardium.


name: Colorectal Carcinoma Metastatic in the Lung

description: A carcinoma that originates from the wall of the colon or rectum and has spread to the lungs.


name: Locally Advanced Lung Squamous Cell Carcinoma

description: Lung squamous cell carcinoma that has spread to nearly tissues or lymph nodes.


Minimally Invasive Thymoma

description: A thymoma that focally infiltrates the surrounding capsule and invades the mediastinal fat.  This type of thymoma is usually recognized only after microscopic examination.  Grossly, it appears indistinguishable from encapsulated thymoma.


mediastinum liposarcoma

description: A malignant adipose tissue neoplasm of the anterior, middle or posterior mediastinum.


Cystic tumor of atrio-ventricular node

description: A multicystic tumor arising in the inferior interatrial septum in the region of the atrioventricular node. The vast majority of patients present with complete heart block and a minority with partial heart block. Sudden death is reported in approximately 10% of the cases. It is a morphologically benign tumor composed of cuboidal, transitional, or squamoid cells. The cells may also show sebaceous differentiation and originate from the endoderm.


name: Stage IIIB Lung Squamous Cell Carcinoma AJCC v7

description: Stage IIIB includes: (T1a, N3, M0); (T1b, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N3, M0); (T4, N2, M0); (T4, N3, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  N3: Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Pulmonary Artery Intimal Sarcoma

description: A sarcoma arising from the arterial intima of pulmonary arteries.


Advanced Lung Small Cell Carcinoma

description: Small cell lung carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Refractory Pleural Malignant Mesothelioma

description: Pleural malignant mesothelioma that is resistant to treatment.


hemangioma of mediastinum

description: A hemangioma that arises from the mediastinum. It can be of the capillary or the cavernous type.


Lung Small Cell Carcinoma, Y Subtype

description: A molecular subtype of lung small cell carcinoma characterized by the overexpression of yes-associated protein 1 (YAP1) transcription factor.


name: Transformed EGFR-Positive Lung Adenocarcinoma to Small Cell Carcinoma

description: Histologic transformation of EGFR mutation-positive lung adenocarcinoma to small cell carcinoma, following treatment with tyrosine kinase inhibitors.


name: Malignant Mediastinal Germ Cell Tumor with Associated Hematologic Malignancy

description: An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum and is associated with a hematologic malignancy.  The hematologic malignancies are clonally related to the malignant germ cell tumor and include acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, and mastocytosis.


Stage IB Lung Cancer AJCC v8

description: Stage IB includes: T2a, N0, M0. T2a: Tumor measuring more than 3 cm but 4 cm or less in greatest dimension. N0: No regional lymph node metastases. M0: No distant metastasis. (AJCC 8th ed.)


desmoid tumor of chest wall

description: An extraabdominal fibromatosis arising from the soft tissue of the chest wall. It is characterized by the presence of elongated spindle-shaped fibroblasts, collagenous stroma formation, and an infiltrative growth pattern.


name: Refractory Lung Non-Small Cell Carcinoma

description: Non-small cell lung carcinoma that does not respond to treatment.


name: Lung Small Cell Carcinoma, Neuroendocrine-Low Subtype

description: Lung small cell carcinoma characterized by low expression pattern of different neuroendocrine markers such as chromogranin A, synaptophysin, neural cell adhesion molecule 1, and gastrin-releasing peptide. It is associated with increased numbers of infiltrating immune cells (immune oasis phenotype).


SMARCA4-deficient thoracic sarcoma

description: An aggressive, high-grade malignant neoplasm characterized by biallelic inactivation of SMARCA4 gene. It affects adults, usually heavy smokers, and involves the thorax (lung, pulmonary hilum, mediastinum, and/or pleura) with or without chest wall invasion. It is composed of sheets of malignant large round to epithelioid cells. Rhabdoid cells may be present. Increased number of mitoses and necrosis are frequently seen. The prognosis is poor.


Thymoma, type B2, malignant

description: A type B2 thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize.


choriocarcinoma of mediastinum

description: An extragonadal malignant germ cell tumor that arises from the mediastinum and is composed of syncytiotrophoblasts, cytotrophoblasts, and intermediate trophoblasts.  The prognosis is usually poor.


Lung squamous cell carcinoma stage II

description: Stage II includes: IIA (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0) and IIB (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


Resectable Lung Carcinoma

description: Lung carcinoma that is amenable to surgical resection.


name: Unresectable Lung Neuroendocrine Neoplasm

description: A lung neuroendocrine neoplasm that is not amenable to surgical resection.


pleural mesothelioma

description: A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath.


benign neoplasm of sternum

description: A benign neoplasm that involves the sternum.


description: An intrathoracic sympathetic paraganglioma arising from paravertebral paraganglia.  In functional tumors, the hypersecretion of catecholamines results in hypertension.


Childhood Lung Non-Small Cell Carcinoma

description: A rare non-small cell carcinoma of the lung that occurs during childhood.


Locally Advanced Lung Adenocarcinoma

description: Lung adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IIB Lung Squamous Cell Carcinoma AJCC v7

description: Stage IIB includes: (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


Pleural Calcifying Fibrous Tumor

description: A rare, benign, well-circumscribed lesion arising from the pleura. It is characterized by the presence of fibroblasts, lymphoplasmacytic infiltrates, collagenous stroma formation, and dystrophic calcifications. Patients may present with chest pain, dyspnea, cough, or may be asymptomatic.


neoplasm of epicardium

description: A neoplasm (disease) that involves the epicardium.


name: Prostate Carcinoma Metastatic in the Lung

description: A carcinoma that arises from the prostate gland and has spread to the lungs.


name: Thymic Adenocarcinoma, Not Otherwise Specified

description: A primary thymic adenocarcinoma that does not conform to either low-grade papillary adenocarcinoma or enteric-type adenocarcinoma.


Lung Myoepithelioma

description: A very rare benign lung tumor with myoepithelial differentiation.


Childhood Benign Thoracic Neoplasm

description: A childhood neoplasm that arises from the tissues of thorax and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Pleural Malignant Mesothelioma by AJCC v7 Stage

description: A term that refers to the staging of pleural malignant mesothelioma, following the rules of the TNM AJCC v7 classification system.


Mediastinal/Thymic NUT Carcinoma

description: A highly aggressive, poorly differentiated carcinoma that arises from the mediastinum/thymus. It is characterized by mutations and rearrangement of the NUT gene.


name: Stage IV Pleural Malignant Mesothelioma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis present. (AJCC 8th ed.)


Lung Small Cell Carcinoma, I Subtype

description: A molecular subtype of lung small cell carcinoma characterized by the low expression of achaete-scute homolog 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), and POU class 2 homeobox 3 (POU2F3) transcription factor signatures and elevated inflammatory gene signature expression.


Combined Thymic Epithelial Neoplasm

description: A primary thymic epithelial neoplasm, characterized by the presence of at least two distinct areas, one representing a thymoma and the other a carcinoma.  The most aggressive component usually determines the clinical outcome.


Cardiac Extraskeletal Osteosarcoma

description: An extraskeletal osteosarcoma that arises from the heart. It produces osteoid and bone, and occasionally shows chondroblastic differentiation.


Refractory Lung Adenocarcinoma

description: Lung adenocarcinoma that is resistant to treatment.


Stage IA Lung Adenocarcinoma AJCC v7

description: Stage IA includes: (T1a, N0, M0); (T1b, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Squamous Lung Dysplasia

description: A term referring to neoplastic changes in the bronchial epithelium manifested as dysplasia.


benign neoplasm of mediastinum

description: A benign neoplasm that involves the mediastinum.


Thymic Enteric-Type Adenocarcinoma

description: A primary thymic adenocarcinoma characterized by morphological and immunohistochemical features seen in colorectal adenocarcinoma.


name: Stage I Lung Small Cell Carcinoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0) and IB: (T2a, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less n greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Cardiac Papillary Fibroelastoma

description: A rare benign neoplasm of the endocardium.  The vast majority of cases arise in the heart valves.  Histopathologic examination reveals a papilloma lined by endothelial cells with a central avascular core which contains fibroblasts and elastic fibers. Patients may be asymptomatic or present with ischemic or embolic events.


Refractory Malignant Thymoma

description: Malignant thymoma that does not respond to treatment.


thymus lymphoma

description: A lymphoma that arises from the thymus. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma.


Masaoka-Koga Stage IVa

description: The tumor shows metastasis throughout the pleural and/or pericardial spaces.


heart leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm, arising from the heart. It is characterized by a proliferation of neoplastic spindle cells.


Occult Lung Non-Small Cell Carcinoma

description: A non-small cell lung carcinoma detectable by sputum cytology only.  The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed.


name: Stage IIIB Lung Small Cell Carcinoma with Pleural Effusion AJCC v7

description: Stage IIIB small cell lung carcinoma that has spread to the pleural fluid.


name: Malignant Mediastinal Nongerminomatous Germ Cell Tumor

description: An extragonadal nongerminomatous malignant germ cell tumor that arises from the mediastinum.  This category includes embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mixed germ cell tumors.


Secondary malignant neoplasm of lung

description: The spread of a malignant neoplasm to the lung. This may be from a primary lung malignant neoplasm, or from a malignant neoplasm at a distant site.


Lung Synovial Sarcoma

description: A synovial sarcoma arising from the lungs.


name: Pleural mesothelioma malignant localised

description: A mesothelioma that arises from the pleura with the gross appearance of a circumscribed lesion and the microscopic appearance of diffuse malignant mesothelioma, without evidence of diffuse spread.


name: Metastatic Intrathoracic Paravertebral Paraganglioma

description: An intrathoracic paravertebral paraganglioma that metastasizes to other anatomic sites.


name: Non-mucinous adenocarcinoma in situ of lung

description: Lung adenocarcinoma in situ characterized by the presence of type II pneumocyte and/or Clara cell differentiation. Almost all cases of lung adenocarcinoma in situ are non-mucinous.


myocardium cancer

description: A malignant neoplasm involving the myocardium.


name: Stage III Pleural Malignant Mesothelioma AJCC v7

description: Stage III includes: (T1, T2, N1, M0); (T1, T2, N2, M0); (T3, N0, N1, N2, M0).  T1: Pleural mesothelioma with a tumor limited to the ipsilateral parietal pleura with or without mediastinal pleura and with or without diaphragmatic pleural involvement. T2: Pleural mesothelioma with a tumor involving each of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following: involvement of diaphragmatic muscle; extension of tumor from visceral pleura into the underlying pulmonary parenchyma.  T3: Pleural mesothelioma with a locally advanced but potentially respectable tumor.  Tumor involving all the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following: involvement of the endothoracic fascia; extension into the mediastinal fat; solitary, completely respectable focus of tumor extending into the soft tissues of the chest wall; nontransmural involvement of the pericardium.  N0: No regional lymph node metastasis.  N1: Pleural mesothelioma with metastases in the ipsilateral bronchopulmonary or hilar lymph nodes. N2: Pleural mesothelioma with metastases in the subcarinal or the ipsilateral mediastinal lymph nodes including the ipsilateral internal mammary and peridiaphragmatic nodes. M0: No distant metastasis. (AJCC 7th ed.)


Lung Mucinous Adenocarcinoma In Situ

description: A very rare lung adenocarcinoma in situ variant characterized by the presence of tall columnar cells with basal nuclei and abundant cytoplasmic mucin.


Pleural Biphasic Synovial Sarcoma

description: A biphasic synovial sarcoma arising in the pleural cavity.


Pleural mesothelioma malignant advanced

description: Malignant mesothelioma that arises from the pleura and is classified as stage II, stage III, or stage IV.


Adenocarcinoma of lung, stage IV

description: Stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b).  M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion.  M1b: Distant metastasis. (AJCC 7th ed.)


name: Metastatic Lung Non-Small Cell Carcinoma

description: A non-small cell carcinoma that arises from the lung and has metastasized to another anatomic site.


Refractory Thymic Carcinoma

description: Thymic carcinoma that does not respond to treatment.


name: Combined Lung Small Cell Carcinoma and Lung Adenocarcinoma

description: A lung carcinoma characterized by a combination of small cell carcinoma and adenocarcinoma.


Lung squamous cell carcinoma stage III

description: Stage III includes: IIIA (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0) and IIIB (T1a, N3, M0); (T1b, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N3, M0); (T4, N2, M0); (T4, N3, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  N3: Lung cancer with metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Metastatic Lung Non-Small Cell Squamous Carcinoma

description: A squamous non-small cell carcinoma that arises from the lung and has metastasized to another anatomic site.


name: Unresectable Lung Neuroendocrine Carcinoma

description: Lung neuroendocrine carcinoma that is not amenable to surgical resection.


Metastatic malignant neoplasm to heart

description: A malignant neoplasm that has spread to the heart from another primary anatomic site.


name: Locally Advanced Lung Non-Small Cell Squamous Carcinoma

description: A non-small cell squamous carcinoma of the lung that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Transformed EGFR-Positive Lung Non-Small Cell Carcinoma to Small Cell Carcinoma

description: Histologic transformation of EGFR mutation-positive lung non-small cell carcinoma to small cell carcinoma, following treatment with tyrosine kinase inhibitors.


pleural lipoma

description: A benign adipose tissue neoplasm of the pleural cavity. It may be purely intra-thoracic or extend to the chest wall.


Lung Cancer by AJCC v6 Stage

description: A term that refers to the staging of lung carcinoma according to the American Joint Committee on Cancer, 6th edition.


name: Lung Carcinoma Metastatic in the Central Nervous System

description: A carcinoma that has spread to the central nervous system from its original site in the lung, through the hematogenous route.


Stage II Lung Cancer AJCC v6

description: Stage II includes: IIA (T1, N1, M0) and IIB (T2, N1, M0) or (T3, N0, M0).  T1: Tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus.  T2: Tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung.  T3: Tumor (of any size) directly invades any of the following: chest wall (including superior sulcus tumors), diaphragm, mediastinal pleura, parietal pericardium; or tumor in the main bronchus less than 2 cm distal to the carina but without involvement of the carina; or associated atelectasis or obstructive pneumonitis of the entire lung. N0: No regional lymph node metastasis.  N1: Metastasis to ipsilateral peribronchial and/or ipsilateral hilar lymph nodes, and intrapulmonary nodes including involvement by direct extension of the primary tumor. M0: No distant metastasis. (AJCC 6th ed.)


name: Stage IV Lung Small Cell Carcinoma AJCC v7


name: Refractory Lung Non-Squamous Non-Small Cell Carcinoma

description: Non-squamous non-small cell lung carcinoma that is resistant to treatment.


Lung Small Cell Carcinoma, P Subtype

description: A molecular subtype of lung small cell carcinoma characterized by the overexpression of POU class 2 homeobox 3 (POU2F3) transcription factor.


Stage III Lung Cancer AJCC v8

description: Stage III includes: IIIA: (T1a, N2, M0); (T1b, N2, M0); (T1c, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0); IIIB: (T1a, N3, M0); (T1b, N3, M0); (T1c, N3, M0); (T2a, N3, M0); (T2b, N3, M0); (T3, N2, M0); (T4, N2, M0); IIIC: (T3, N3, M0); (T4, N3, M0). T1a: Tumor measuring 1 cm or less in greatest dimension. A superficial, spreading tumor of any size whose invasive component is limited to the bronchial wall and may extend proximal to the main bronchus also is classified as T1a, but these tumors are uncommon. T1b: Tumor measuring more than 1 cm but 2 cm or less in greatest dimension. T1c: Tumor measuring more than 2 cm but 3 cm or less in greatest dimension. T2a: Tumor measuring more than 3 cm but 4 cm or less in greatest dimension. T2b: Tumor measuring more than 4 cm but 5 cm or less in greatest dimension. T3: Tumor measuring more than 5 cm but 7 cm or less in greatest dimension or directly invading any of the following: parietal pleura (PL3), chest wall (including superior sulcus tumors), phrenic nerve, parietal pericardium; or separate tumor nodule(s) in the same lobe as the primary. T4: Tumor measuring more than 7 cm or tumor of any size invading one or more of the following: diaphragm, mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, or carina; separate tumor nodule(s) in an ipsilateral lobe different from that of the primary. N0: No regional lymph node metastases. N1: Metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension. N2: Metastasis in ipsilateral mediastinal and/or subcarinal lymph node(s). N3: Metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s). M0: No distant metastasis. (AJCC 8th ed.)


Adenocarcinoma of lung, stage I

description: Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0) and IB: (T2a, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less n greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Lung Mixed Squamous Cell and Glandular Papilloma

description: An exceedingly rare benign endobronchial neoplasm characterized by the presence of fibrovascular cores which are lined by both squamous and glandular epithelium. Patients present with obstructive symptoms. Complete resection is curative.


Childhood Malignant Thoracic Neoplasm

description: A malignant neoplasm that involves the tissues of the thorax during childhood.


carcinosarcoma of lung

description: A morphologic variant of lung sarcomatoid carcinoma composed of a mixture of non-small cell lung carcinoma and a sarcomatous component.


name: Lung Squamous Cell Carcinoma, Clear Cell Variant

description: A morphologic variant of squamous cell lung carcinoma characterized by the presence of clear cells.


Masaoka-Koga Stage IIb

description: The tumor shows invasion through the capsule and into the surrounding fatty tissue.


olfactory receptor 52N2 (rat)

An olfactory receptor 52N2 that is encoded in the genome of rat.


name: DNA fragmentation factor subunit beta isoform Alpha (human)

description: A DNA fragmentation factor subunit beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O76075-1.


name: YQ93_CAEEL Uncharacterized protein C27D6.3 (sprot)

description: A protein that is a translation product of the C27D6.3 gene in worm.


name: RL19_STRA5 Large ribosomal subunit protein bL19 (sprot)

description: A large ribosomal subunit protein bL19 that is encoded in the genome of Streptococcus agalactiae 2603V/R.


constitutional neutropenia

description: A rare disorder characterized by recurrent infantile infections and absence of neutrophils in the peripheral blood.


description: Neutropenia-monocytopenia-deafness syndrome is characterized by neutropenia with myeloid marrow hypoplasia, monocytopenia, and congenital deafness. It has been described in three siblings who suffered recurrent bacterial infections.


name: autosomal recessive severe congenital neutropenia due to JAGN1 deficiency

description: Severe congenital neutropenia inherited in an autosomal recessive pattern and caused by mutation(s) in the JAGN1 gene, encoding protein jagunal homolog 1.


name: primary immunodeficiency syndrome due to p14 deficiency

description: Primary immunodeficiency syndrome due to p14 deficiency is characterized by short stature, hypopigmentation, coarse facies and frequent bronchopulmonary Streptococcus pneumoniae infections.


Lichtenstein syndrome

description: Lichstenstein syndrome is characterized by frequent infections associated with osteoporosis, a tendency for fractures and osseous anomalies. It has been described in two monozygotic twin brothers. Transmission is autosomal recessive.


X-linked severe congenital neutropenia

description: This syndrome is an immunodeficiency syndrome characterized by recurrent major bacterial infections, severe congenital neutropenia, and monocytopenia. It has been described in five males spanning three generations of one family. It is transmitted as an X-linked recessive trait and is caused by mutations in the WAS gene, encoding the WASP protein.


name: neutropenia, severe congenital, 11, autosomal dominant


Kostmann syndrome

description: Kostmann syndrome is a rare, severe, congenital neutropenia disorder characterized by a lack of mature neutrophils (absolute neutrophil counts less than 500 cells/mm3) associated with frequent, recurrent bacterial infections (e.g. otitis media, pneumonia, sinusitis, urinary tract infections, abscesses of skin and/or liver) and increased promyelocytes in the bone marrow. Periodontal disease, as well as neurological symptoms, such as cognitive impairment, severe neurodegeneration and epilepsy, have been reported in some patients.


WHIM syndrome 1

description: A congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).


name: autosomal recessive severe congenital neutropenia due to CXCR2 deficiency


name: autosomal recessive severe congenital neutropenia

description: Severe congenital neutropenia inherited in an autosomal recessive pattern.


name: neutropenia, severe congenital, 8, autosomal dominant


description: Severe congenital neutropenia inherited in an autosomal recessive pattern and caused by mutation(s) in the VPS45 gene, encoding vacuolar protein sorting-associated protein 45. It is characterized by neutrophil dysfunction, a lack of response to G-CSF, life-threatening infections, bone marrow fibrosis, and renal extramedullary hematopoiesis.


name: neutropenia, severe congenital, 2, autosomal dominant

description: Any autosomal dominant severe congenital neutropenia in which the cause of the disease is a mutation in the GFI1 gene.


name: neutropenia, severe congenital, 10, autosomal recessive


name: autosomal recessive severe congenital neutropenia due to CSF3R deficiency

description: Severe congenital neutropenia inherited in an autosomal recessive pattern and caused by mutation(s) in the CSF3R gene, encoding granulocyte colony-stimulating factor receptor. It is characterized by the onset of recurrent infections in infancy or early childhood and peripheral neutropenia, despite normal granulocyte maturation, that is unresponsive to treatment with G-CSF.


name: neutropenia, lethal congenital, with eosinophilia


glycogen storage disease Ib

description: A type of glycogenosis due to G6P deficiency.


name: neutropenia, severe congenital, 1, autosomal dominant

description: Severe congenital neutropenia inherited in an autosomal dominant pattern and caused by mutation(s) in the ELANE gene, encoding neutrophil elastase


Cohen syndrome

description: Cohen syndrome (CS) is a rare genetic developmental disorder characterized by microcephaly, characteristic facial features, hypotonia, non-progressive intellectual deficit, myopia and retinal dystrophy, neutropenia and truncal obesity.


name: autosomal recessive severe congenital neutropenia due to G6PC3 deficiency

description: Severe congenital neutropenia inherited in an autosomal recessive pattern and caused by mutation(s) in the G6PC3 gene, encoding glucose-6-phosphatase 3. It is characterized by cardiac abnormalities, hepatosplenomegaly, intermittent thrombocytopenia and a prominent superficial venous pattern.


name: autosomal dominant severe congenital neutropenia

description: Autosomal dominant form of severe congenital neutropenia.


name: neutropenia, severe congenital, 9, autosomal dominant


poikiloderma with neutropenia

description: A skin disease characterized by poikiloderma, hyperkeratotic nails, generalized hyperkeratosis on palms and soles, neutropenia, short stature, and recurrent pulmonary infections. It has material basis in mutation in the C16ORF57 gene on chromosome 16q13.


name: lipoyl amidotransferase LIPT1, mitochondrial phosphorylated 1 (human)

description: A lipoyl amidotransferase LIPT1, mitochondrial (human) that has been phosphorylated on the residue at the position equivalent to Ser-191 of the amino acid sequence represented by UniProtKB:Q9Y234. UniProtKB:Q9Y234, Ser-191, MOD:00046.


name: ribonucleoside-diphosphate reductase large subunit isoform 1 (human)

description: A ribonucleoside-diphosphate reductase large subunit isoform 1 that is encoded in the genome of human.


name: RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit (sprot)

description: A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of human.


name: ribonucleoside-diphosphate reductase large subunit methylated 2 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been methylated on the residue at the position equivalent to Cys-429 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Cys-429, MOD:00660.


name: ribonucleoside-diphosphate reductase large subunit deaminated 2 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been deaminated on the residue at the position equivalent to Gln-530 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Gln-530, MOD:00685.


name: ribonucleoside-diphosphate reductase large subunit methylated 1 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been methylated on the residue at the position equivalent to Cys-26 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Cys-26, MOD:00660.


name: ribonucleoside-diphosphate reductase large subunit cysteinylated 2 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been cysteinylated on the residue at the position equivalent to Cys-444 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Cys-444, MOD:00765.


name: ribonucleoside-diphosphate reductase large subunit deaminated 1 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been deaminated on the residue at the position equivalent to Asn-85 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Asn-85, MOD:00684.


name: ribonucleoside-diphosphate reductase large subunit deaminated 3 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been deaminated on the residue at the position equivalent to Gln-678 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Gln-678, MOD:00685.


name: ribonucleoside-diphosphate reductase large subunit cysteinylated 1 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been cysteinylated on the residue at the position equivalent to Cys-26 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Cys-26, MOD:00765.


name: ribonucleoside-diphosphate reductase large subunit cysteinylated 3 (human)

description: A ribonucleoside-diphosphate reductase large subunit (human) that has been cysteinylated on the residue at the position equivalent to Cys-429 of the amino acid sequence represented by UniProtKB:P23921. UniProtKB:P23921, Cys-429, MOD:00765.


name: Atherosclerosis of Non-Biological Bypass Graft(s) of the Right Leg with Ulceration of Ankle

description: Evidence of atherosclerosis of non-biological bypass graft(s) of the right leg with ulceration of ankle.


name: KLH24_MOUSE Kelch-like protein 24 (sprot)

description: A kelch-like protein 24 that is encoded in the genome of mouse.


kelch-like protein 24

A protein that is a translation product of the human KLHL24 gene or a 1:1 ortholog thereof.


name: kelch-like protein 24 cysteinylated 1 (human)

description: A kelch-like protein 24 (human) that has been cysteinylated on the residue at the position equivalent to Cys-71 of the amino acid sequence represented by UniProtKB:Q6TFL4-1. Example: UniProtKB:Q6TFL4-1, Cys-71, MOD:00765.


kelch-like protein 24 isoform 1

A kelch-like protein 24 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6TFL4-1 or a 1:1 ortholog thereof.


name: kelch-like protein 24 methylated 4 (human)

description: A kelch-like protein 24 (human) that has been methylated on the residue at the position equivalent to Cys-597 of the amino acid sequence represented by UniProtKB:Q6TFL4-1. Example: UniProtKB:Q6TFL4-1, Cys-597, MOD:00660.


name: kelch-like protein 24 methylated 1 (human)

description: A kelch-like protein 24 (human) that has been methylated on the residue at the position equivalent to Cys-587 of the amino acid sequence represented by UniProtKB:Q6TFL4-1. Example: UniProtKB:Q6TFL4-1, Cys-587, MOD:00660.


name: kelch-like protein 24 deaminated 1 (human)

description: A kelch-like protein 24 (human) that has been deaminated on the residue at the position equivalent to Asn-480 of the amino acid sequence represented by UniProtKB:Q6TFL4-1. Example: UniProtKB:Q6TFL4-1, Asn-480, MOD:00684.


name: kelch-like protein 24 isoform h2 (human)

description: A kelch-like protein 24 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6TFL4-2.


kelch-like protein 24 isoform 1 (human)

A kelch-like protein 24 isoform 1 that is encoded in the genome of human.


name: KLH24_HUMAN Kelch-like protein 24 (sprot)

description: A kelch-like protein 24 that is encoded in the genome of human.


name: kelch-like protein 24 methylated 3 (human)

description: A kelch-like protein 24 (human) that has been methylated on the residue at the position equivalent to Cys-321 of the amino acid sequence represented by UniProtKB:Q6TFL4-1. Example: UniProtKB:Q6TFL4-1, Cys-321, MOD:00660.


name: kelch-like protein 24 hydroxylated 1 (human)

description: A kelch-like protein 24 (human) that has been hydroxylated on the residue at the position equivalent to Trp-524 of the amino acid sequence represented by UniProtKB:Q6TFL4-1. Example: UniProtKB:Q6TFL4-1, Trp-524, MOD:01622.


Grade 2 Non-Malignant Ascites, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: porokeratosis 8, disseminated superficial actinic type


linear porokeratosis

description: Linear porokeratosis is a rare skin condition characterized by streaks of reddish-brown patches surrounded by a ridge-like border.The patches usually develop in infants or young children, but they sometimes develop in adults.


name: porokeratosis 6, disseminated superficial actinic type


porokeratosis 9, multiple types

description: Any porokeratosis (disease) in which the cause of the disease is a mutation in the FDPS gene.


name: disseminated superficial actinic porokeratosis

description: Disseminated superficial actinic porokeratosis (DSAP) is the most common form of porokeratosis characterized by the presence of several small annular plaques with a distinctive keratotic rim found most commonly on sun-exposed areas of the skin, particularly the extremities.


name: porokeratosis 5, disseminated superficial actinic type


porokeratosis of Mibelli

description: Porokeratosis of Mibelli (PM) is a form of porokeratosis that is characterized by the presence of brown single or multiple annular plaques of varying size, that are sometimes confluent, with a distinctive sharply-defined keratotic border.


name: porokeratosis 4, disseminated superficial actinic type


name: porokeratosis 3, disseminated superficial actinic type


name: porokeratosis plantaris palmaris et disseminata

description: Porokeratosis plantaris palmaris et disseminata (PPPD) is a rare form of porokeratosis occurring mainly in adolescence and characterized by small pruritic or painful keratotic papules that first appear on the palms and soles, and may gradually become generalized.


A ceramide phosphoethanolamine in which the sphingoid component is specified as icosaphytosphingosine.


name: focal adhesion kinase 1 isoform 1 phosphorylated 3 (rat)

description: A focal adhesion kinase 1 isoform 1 (rat) that has been phosphorylated on the residue at the position equivalent to Tyr-928. UniProtKB:O35346-1, Tyr-928, MOD:00048.


name: histone-lysine N-methyltransferase NSD2 isoform h7 (human)

description: A histone-lysine N-methyltransferase NSD2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O96028-7.


name: YG29_YEAST Uncharacterized protein YGR066C (sprot)

description: A protein that is a translation product of the YGR066C gene in yeast.


anaplasmosis in cattle

description: A disease of cattle caused by parasitization of the red blood cells by bacteria of the genus ANAPLASMA.


name: MBS2_ARATH Protein METHYLENE BLUE SENSITIVITY 2 (sprot)

description: A protein that is a translation product of the MBS2 gene in Arabidopsis thaliana.


name: EMC7_DANRE Endoplasmic reticulum membrane protein complex subunit 7 (sprot)

description: An ER membrane protein complex subunit 7 that is encoded in the genome of zebrafish.


name: IPYR1_ARATH Soluble inorganic pyrophosphatase 1 (sprot)

description: A protein that is a translation product of the PPA1 gene in Arabidopsis thaliana.


name: serine protease inhibitor Kazal-type 13 isoform 1 (rat)

description: A serine protease inhibitor Kazal-type 13 isoform 1 that is encoded in the genome of rat.


leukosialin O-glycosylated 58 (human)

A leukosialin (human) that has been O-glycosylated at the residue equivalent to Ser-99 of the amino acid sequence represented by UniProtKB:P16150-1, in which the glycan structure is represented by GlyTouCan:G01614ZM. Example: UniProtKB:P16150-1, Ser-99, MOD:00002~GNO:G01614ZM.


name: Conjunctival Melanoma cT2a TNM Finding v8

description: Conjunctival melanoma with noncaruncular tumor, and 1 or less quadrant of the nonbulbar conjunctiva involved. (from AJCC 8th Ed.)


name: 60S ribosomal protein L23a, initiator methionine removed form (human)

description: A large ribosomal subunit protein uL23 (human) that has had the initiator methionine removed. UniProtKB:P62750, 2-156.


name: THO complex subunit 7 homolog isoform 1 (mouse)

description: A THO complex subunit 7 isoform 1 that is encoded in the genome of mouse.


DPEP3_HUMAN Dipeptidase 3 (sprot)

A dipeptidase 3 that is encoded in the genome of human.


A member of the class of 3-nitrophenols that is phenol in which one of the hydrogens that is meta to the hydroxy group has been replaced by a nitro group.


name: taste receptor type 2 member 40 isoform 1 (mouse)

description: A taste receptor type 2 member 40 isoform 1 that is encoded in the genome of mouse.


name: T2R40_MOUSE Taste receptor type 2 member 40 (sprot)

description: A taste receptor type 2 member 40 that is encoded in the genome of mouse.


name: T-cell surface protein tactile, signal peptide removed form (human)

description: A T-cell surface protein tactile (human) that has had the signal peptide removed. UniProtKB:P40200, 22-585.


name: serine/threonine-protein kinase 4 hydroxylated 1 (human)

description: A serine/threonine-protein kinase 4 (human) that has been hydroxylated on the residue at the position equivalent to Trp-99 of the amino acid sequence represented by UniProtKB:Q13043-1. Example: UniProtKB:Q13043-1, Trp-99, MOD:01622.


inner membrane transport protein YhjV

A protein that is a translation product of the Escherichia coli K-12 yhjV gene or a 1:1 ortholog thereof.


name: YHJV_ECOLI Inner membrane transport protein YhjV (sprot)

description: An inner membrane transport protein YhjV that is encoded in the genome of Escherichia coli K-12.


ethmoid sinusitis

description: An acute or chronic inflammatory process affecting the mucous membrane of the ethmoid sinus.


acute ethmoiditis

description: Acute form of ethmoid sinusitis.


chronic ethmoidal sinusitis

description: Inflammation of the ethmoid sinus that typically lasts beyond eight weeks. It is caused by infections, allergies, and the presence of sinus polyps or a deviated septum. Signs and symptoms include headache, nasal discharge, swelling in the face, dizziness, and breathing difficulties.


tetrahydrofurfuryl alcohol

A primary alcohol that is methanol in which one of the hydrogens of the methyl group has been replaced by a tetrahydrofuran-2-yl group.


name: glycine--tRNA ligase beta subunit, initiator methionine removed form

description: A glycine--tRNA ligase beta subunit that has had the initiator methionine removed.


glycine--tRNA ligase beta subunit

A protein that is a translation product of the Escherichia coli K-12 glyS gene or a 1:1 ortholog thereof.


name: glycine--tRNA ligase, chloroplastic/mitochondrial 2 isoform 2 (Arabidopsis thaliana)

description: A glycine--tRNA ligase, chloroplastic/mitochondrial 2 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8L785-2.


name: SYGB_ECOLI Glycine--tRNA ligase beta subunit (sprot)

description: A glycine--tRNA ligase beta subunit that is encoded in the genome of Escherichia coli K-12.


name: glycine--tRNA ligase, chloroplastic/mitochondrial 2 isoform 1 (Arabidopsis thaliana)

description: A glycine--tRNA ligase, chloroplastic/mitochondrial 2 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8L785-1.


name: SYGM2_ARATH Glycine--tRNA ligase, chloroplastic/mitochondrial 2 (sprot)

description: A glycine--tRNA ligase beta subunit that is encoded in the genome of Arabidopsis thaliana.


name: PHNF_ECOLI Probable transcriptional regulator PhnF (sprot)

description: A probable transcriptional regulator PhnF that is encoded in the genome of Escherichia coli K-12.


probable transcriptional regulator PhnF

A protein that is a translation product of the Escherichia coli K-12 phnF gene or a 1:1 ortholog thereof.


name: infiltrating nipple syringomatous adenoma

description: An invasive, non-metastasizing neoplasm with sweat duct differentiation that arises in the area of the nipple. Local recurrences have been reported.


breast fibroepithelial neoplasm

description: A benign or malignant biphasic neoplasm that arises from the breast parenchyma. It is characterized by the presence of an epithelial and a mesenchymal (stromal) component. The typical examples are fibroadenoma and phyllodes tumor.


breast neuroendocrine neoplasm

description: A neoplasm that arises from the breast and is composed of cells of neuroendocrine origin. Most cases are neuroendocrine carcinomas. Primary carcinoid tumors of the breast are very rare.


name: breasts and/or nipples, aplasia or hypoplasia of, 2

description: Any isolated congenital breast hypoplasia/aplasia in which the cause of the disease is a mutation in the PTPRF gene.


benign eccrine breast spiradenoma

description: A very rare, benign sweat gland neoplasm that affects the breast. It is characterized by the proliferation of basaloid epithelial cells.


name: isolated congenital breast hypoplasia/aplasia


blunt duct adenosis of breast

description: Breast adenosis characterized by the presence of ducts with distended lumen and columnar cell metaplasia.


breast synovial sarcoma

description: A synovial sarcoma (disease) that involves the breast.


breast myofibroblastoma

description: A myofibroblastoma occurring in the breast of both women and men. It presents as a slowly growing mass.


apocrine adenosis of breast

description: Breast adenosis characterized by the presence of extensive apocrine metaplasia.


name: breast fibrocystic change, proliferative type

description: Breast fibrocystic change characterized by the presence of epithelial cell hyperplasia. Epithelial atypia may be present or absent.


breast phyllodes tumor

description: A benign, malignant, or borderline circumscribed biphasic neoplasm that arises from the breast. It usually affects middle-aged women. It is characterized by the presence of a double layer of epithelial cells that are arranged in clefts, surrounded by a spindle cell mesenchymal (stromal) component.


breast fibrosis

description: Breast fibrocystic change characterized by the prominence of fibrotic changes in the parenchyma.


breast cyst

description: A cystic lesion located in breast tissue.


name: salivary gland type cancer of the breast

description: A group of uncommon neoplasms, usually seen in the salivary glands but occurring in the breast, with a variable clinicopathologic spectrum and divided into those with myoepithelial differentiation and those without. This group includes mammary adenoid cystic carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, polymorphous low-grade adenocarcinoma and oncocytic carcinoma.


acropectororenal dysplasia

description: Acro-pectoro-renal field defect is a very rare association of a Poland anomaly, that is characterized by unilateral absence or hypoplasia of the pectoralis major muscle (most frequently involving the sternocostal head) and a variable degree of ipsilateral hand anomalies (including symbrachydactyly, brachydactyly, absent thumb and hypoplastic fingers), combined with a genito-urinary anomaly. Associated genito-urinary anomalies reported include renal hypoplasia or agenesis, duplex collecting system, ureteropelvic junction obstruction, hypospadias and undescended testicles.


intraductal breast neoplasm

description: A benign or malignant epithelial neoplasm that arises anywhere in the ductal system of the breast. This category includes intraductal papilloma, intraductal papillary carcinoma, ductal hyperplasia with or without atypia, and ductal carcinoma in situ.


solitary cyst of breast

description: A single, fluid-filled cyst in the breast parenchyma.


microglandular adenosis of breast

description: A rare variant of breast adenosis characterized by the proliferation of small round glands in a collagenous stroma. The epithelial cells are cuboidal and there are no myopepithelial cells present. There is no evidence of atypia.


breast implant illness

description: A syndrome that is characterized by fatigue, problems with memory or concentration, joint and muscle pain, hair loss, weight changes and anxiety/depression. This syndrome may be related to breast implants


lactocele

description: Single or multiple, milk-containing nodules in the breast. It is caused by obstruction of the breast ducts during lactation. Needle aspiration of the milk is the treatment of choice.


benign breast phyllodes tumor

description: A usually unilateral, benign and well circumscribed biphasic neoplasm that arises from the breast. It usually affects middle-aged women. It is characterized by the presence of a double layer of epithelial cells that are arranged in clefts, surrounded by a cellular, monomorphic spindle cell mesenchymal component. Mitoses are rare. Necrotic changes may be present in large tumors.


breast adenosis

description: A non-neoplastic disorder characterized by epithelial and/or myoepithelial tissue growth in the breast lobules. It may be associated with apocrine changes or sclerosis.


breast intraductal proliferative lesion

description: A group of non-invasive epithelial proliferations that occur in the ductal system of the breast. The vast majority of cases arise in the terminal ductal lobular units. This category includes atypical ductal hyperplasia, usual ductal hyperplasia, flat epithelial atypia, and ductal carcinoma in situ. There is an increased risk for subsequent development of invasive breast carcinoma.


breast adenomyoepithelial adenosis

description: An uncommon variant of breast adenosis characterized by the presence of irregularly shaped glands, epithelial cells with eosinophilic cytoplasm, and prominent myopepithelial cells. Mild atypia may be present.


breast giant fibroadenoma

description: A breast fibroadenoma characterized by a very large size. This term has also been used as a synonym for juvenile fibroadenoma by some authors. The latter is characterized by epithelial hyperplasia and an increased stromal cellularity.


nipple neoplasm

description: A benign or malignant neoplasm that arises in the area of the nipple.


name: familial juvenile hypertrophy of the breast

description: Familial juvenile hypertrophy of the breast is a rare breast malformation disorder characterized by unilateral or bilateral, symmetrical or asymmetrical, uncontrolled, rapid and massive enlargement of the breast(s) in peripubertal females, occurring in various members of a family. Additional associated manifestations may include skin hyperemia, dilated subcutaneous veins, skin necrosis, kyphosis, lordosis and anonychia. Growth and development are otherwise normal.


benign neoplasm of male breast

description: A non-metastasizing neoplasm that arises from the breast parenchyma in males.


multiple fibroadenoma of the breast

description: Mammary polyadenomatosis is characterized by the presence in both breasts of multiple voluminous fibroadenomas with heterogeneous echo patterns.


name: craniofrontonasal dysplasia-Poland anomaly syndrome

description: Cranio-fronto-nasal dysplasia - Poland anomaly is a polymalformative syndrome characterized by craniosynostosis, Poland anomaly, cranio-fronto-nasal dysplasia, and genital and breast anomalies. Less than ten cases have been described so far.


usual ductal breast hyperplasia

description: A neoplastic ductal proliferative lesion of the breast characterized by the formation of secondary lumens and prominent intraductal proliferation of a heterogeneous cellular population that may include epithelial cells, myoepithelial cells, or metaplastic apocrine cells.


breast angiomatosis

description: A benign diffuse vascular proliferation in the breast. It is characterized by the formation of capillary-sized and cavernous vascular spaces.


breast benign neoplasm

description: A non-metastasizing neoplasm arising from the breast parenchyma.


name: breasts and/or nipples, aplasia or hypoplasia of, 1


flat ductal epithelial atypia

description: A breast lesion characterized by the presence of dilated terminal ductal lobular units in which the epithelial lining has been replaced by a single layer of mildly atypical cells, or there is atypical, monotonous epithelial hyperplasia of three to five layers. This lesion relates to columnar cell change with atypia and columnar cell hyperplasia with atypia.


breast lipoma

description: A benign, mesenchymal neoplasm that arises from the breast. It is surrounded by a thin capsule and composed of mature adipose tissue cells. Atypia is absent.


name: non-proliferative fibrocystic change of the breast

description: Breast fibrocystic change characterized by the absence of epithelial cell hyperplasia.


infant gynecomastia

description: Transient bilateral swelling of breast tissue in a neonate that results from the waning influence of maternal estrogen.


diabetic mastopathy

description: Diabetic mastopathy are noncancerous lesions in the breast most commonly diagnosed in premenopausal women with type 1 diabetes. The cause of this condition is unknown. Symptoms may include hard, irregular, easily movable, discrete, painless breast mass(es).


sclerosing adenosis of breast

description: Breast adenosis characterized by the proliferation of acini, a lobulated architectural pattern, and stromal sclerosis. The luminal epithelial and myopepithelial cells are preserved. Microcalcifications and foci of apocrine metaplasia may be present.


breast pericanalicular fibroadenoma

description: A morphologic variant of breast fibroadenoma without clinical significance. It is characterized by circumferential proliferation of stromal cells around the ducts. This results in the formation of rounded ductal-epithelial structures.


breast intracanalicular fibroadenoma

description: A morphologic variant of breast fibroadenoma without clinical significance. It is characterized by distortion and compression of the ducts by proliferating stromal cells.


fat necrosis of breast

description: Localized necrosis of the adipose tissue in the breast. Clinically, it may present as a mass. Causes include injury, surgical procedures, and radiation treatment.


intraductal papillary breast neoplasm

description: A benign or malignant papillary neoplasm that arises anywhere in the ductal system of the breast. It is characterized by fibrovascular structures lined by epithelial proliferations. This category includes intraductal papilloma and intraductal papillary carcinoma.


name: partner and localizer of BRCA2 sequence variant G796* (human)

description: A partner and localizer of BRCA2 (human) that has has been truncated after the position equivalent to Gln-795 of the amino acid sequence represented by UniProtKB:Q86YC2. UniProtKB:Q86YC2, 1-795.


name: hyaluronan and proteoglycan link protein 1 isoform 1 (human)

description: A hyaluronan and proteoglycan link protein 1 isoform 1 that is encoded in the genome of human.


name: hyaluronan and proteoglycan link protein 1

description: A hyaluronan and proteoglycan link protein that is a translation product of the human HAPLN1 gene or a 1:1 ortholog thereof.


name: hyaluronan and proteoglycan link protein 1 proteolytic cleavage product

description: A hyaluronan and proteoglycan link protein 1 that has been processed by proteolytic cleavage.


name: HPLN1_RAT Hyaluronan and proteoglycan link protein 1 (sprot)

description: A hyaluronan and proteoglycan link protein 1 that is encoded in the genome of rat.


name: hyaluronan and proteoglycan link protein 1 isoform 1

description: A hyaluronan and proteoglycan link protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10915-1 or a 1:1 ortholog thereof.


name: HPLN1_MOUSE Hyaluronan and proteoglycan link protein 1 (sprot)

description: A hyaluronan and proteoglycan link protein 1 that is encoded in the genome of mouse.


name: HPLN1_CHICK Hyaluronan and proteoglycan link protein 1 (sprot)

description: A hyaluronan and proteoglycan link protein 1 that is encoded in the genome of chicken.


name: hyaluronan and proteoglycan link protein 1 isoform Long (rat)

description: A hyaluronan and proteoglycan link protein 1 isoform 1 that is encoded in the genome of rat.


name: HPLN1_HUMAN Hyaluronan and proteoglycan link protein 1 (sprot)

description: A hyaluronan and proteoglycan link protein 1 that is encoded in the genome of human.


name: PHT16_ARATH Probable inorganic phosphate transporter 1-6 (sprot)

description: A putative metabolite transport protein YaaU that is encoded in the genome of Arabidopsis thaliana.


name: ASCL4_HUMAN Achaete-scute homolog 4 (sprot)

description: An achaete-scute homolog 4 that is encoded in the genome of human.


name: Ampicillin Sodium Mixture With Sulbactam Sodium


epicillin

A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido group.


flavocillin

A penicillin in which the substituent at position 6 of the penam ring is a [3-(4-oxo-4H-chromen-2-yl)benzoyl]nitrilo group.


sulbenicillin

A penicillin antibiotic having a 6beta-[phenyl(sulfo)acetamido] side-chain.


Penicillanic acid carrying a (p-aminophenyl)imino]pentylidene}amino substituent at the 6beta position. It has been used as a hapten in the production of a generic monoclonal antibody for determining penicillin residues in milk.


metampicillin

A penicillin compound having a 6beta-(2R)-2-(methylideneamino)-2-phenylacetamido side-group.


almecillin

A penicillin where the side-chain N-acyl group is specified as allylmercaptoacetyl. Antibiotic isolated from Penicillium chrysogenum.


QUINACILLIN

A semisynthetic penicillase-resistant penicillin with antibacterial activity; it binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall.


N-benzoylampicillin

A penicillin that is the N-benzoyl derivative of ampicillin.


clometocillin

A penicillin that is benzylpenicillin in which the phenylacetyl group has been replaced by a (3,4-dichlorophenyl)(methoxy)acetyl group. It is a mixture of epimers at the methoxy-bearing carbon.


Penicillanic acid carrying a (p-hydroxybenzylidene)amino substituent at the 6beta position. It has been used as a hapten in the production of a generic monoclonal antibody for determining penicillin residues in milk.


penicillin allergen

Any penicillin which causes the onset of an allergic reaction.


name: GIMA6_RAT GTPase IMAP family member 6 (sprot)

description: A GTPase IMAP family member 6 that is encoded in the genome of rat.


name: CLH_SCHPO Probable clathrin heavy chain (sprot)

description: A clathrin heavy chain 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-.


Grade 1 Jejunal Fistula, CTCAE

description: Asymptomatic


name: TSG13_MOUSE Testis-specific gene 13 protein (sprot)

description: A testis-specific gene 13 protein that is encoded in the genome of mouse.


testis-specific gene 13 protein

A protein that is a translation product of the human TSGA13 gene or a 1:1 ortholog thereof.


name: TSG13_HUMAN Testis-specific gene 13 protein (sprot)

description: A testis-specific gene 13 protein that is encoded in the genome of human.


name: testis-specific gene 13 protein deaminated 1 (human)

description: A testis-specific gene 13 protein (human) that has been deaminated on the residue at the position equivalent to Gln-89 of the amino acid sequence represented by UniProtKB:Q96PP4. UniProtKB:Q96PP4, Gln-89, MOD:00685.


D-xylulose 5-phosphate

The D-enantiomer of xylulose 5-phosphate.


xylulose 5-phosphate

A xylulose phosphate in which the phosphate group is at position 5. It is an intermediate metabolite in the pentose phosphate pathway.


L-xylulose 5-phosphate

The 5-O-phospho derivative of L-xylulose.


name: NLP68_CAEEL Neuropeptide-like protein 68 (sprot)

description: A protein that is a translation product of the nlp-68 gene in worm.


name: U5 small nuclear ribonucleoprotein 200 kDa helicase isoform 1 (mouse)

description: A U5 small nuclear ribonucleoprotein 200 kDa helicase isoform 1 that is encoded in the genome of mouse.


name: U5 small nuclear ribonucleoprotein 200 kDa helicase isoform 1

description: A U5 small nuclear ribonucleoprotein 200 kDa helicase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75643-1 or a 1:1 ortholog thereof.


name: U5 small nuclear ribonucleoprotein 200 kDa helicase isoform 1 (human)

description: A U5 small nuclear ribonucleoprotein 200 kDa helicase isoform 1 that is encoded in the genome of human.


name: ROCA_STAA8 1-pyrroline-5-carboxylate dehydrogenase (sprot)

description: A protein that is a translation product of the rocA gene in Staphylococcus aureus subsp. aureus NCTC 8325.


Recurrent Ocular Melanoma

description: The reemergence of ocular melanoma after a period of remission.


Melanoma recurrent

description: The reemergence of a melanoma after a period of remission.


Recurrent Uveal Melanoma

description: The reemergence of uveal melanoma after a period of remission.


Lentigo maligna recurrent

description: The reemergence of lentigo maligna after a period of remission


Recurrent Non-Cutaneous Melanoma

description: The reemergence of non-cutaneous melanoma after a period of remission.


Recurrent Mucosal Melanoma

description: The reemergence of a mucosal melanoma after a period of remission.


name: Recurrent Cutaneous Melanoma of the Extremity

description: Cutaneous melanoma of the upper or lower extremity that has recurred after a period of remission.


Recurrent Acral Lentiginous Melanoma

description: The reemergence of acral lentiginous melanoma after a period of remission.


name: sodium/potassium/calcium exchanger 2 isoform h1 (human)

description: A sodium/potassium/calcium exchanger 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UI40-1.


name: ABC-type oligopeptide transporter ABCB9 isoform 1 (rat)

description: An ABC-type oligopeptide transporter ABCB9 isoform 1 that is encoded in the genome of rat.


name: ABCB9_RAT ABC-type oligopeptide transporter ABCB9 (sprot)

description: An ABC-type oligopeptide transporter ABCB9 that is encoded in the genome of rat.


name: ABC-type oligopeptide transporter ABCB9 isoform r3 (rat)

description: An ABC-type oligopeptide transporter ABCB9 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QYJ4-3.


name: ABC-type oligopeptide transporter ABCB9 isoform r2 (rat)

description: An ABC-type oligopeptide transporter ABCB9 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QYJ4-2.


name: ABC-type oligopeptide transporter ABCB9 isoform r4 (rat)

description: An ABC-type oligopeptide transporter ABCB9 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QYJ4-4.


name: NACHT, LRR and PYD domains-containing protein 2 isoform h1 (human)

description: A NACHT, LRR and PYD domains-containing protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NX02-1.


name: PSUG_ECOLI Pseudouridine-5'-phosphate glycosidase (sprot)

description: A pseudouridine-5'-phosphate glycosidase that is encoded in the genome of Escherichia coli K-12.


name: transforming acidic coiled-coil-containing protein 1 isoform h1 (human)

description: A transforming acidic coiled-coil-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75410-1.


name: SGK1_DANRE Serine/threonine-protein kinase Sgk1 (sprot)

description: A serine/threonine-protein kinase Sgk1 that is encoded in the genome of zebrafish.


name: zinc finger protein 540 isoform h2 (human)

description: A zinc finger protein 540 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NDQ6-2.


name: NDKB_MOUSE Nucleoside diphosphate kinase B (sprot)

description: A nucleoside diphosphate kinase B that is encoded in the genome of mouse.


name: PSPB_ECOLI Phage shock protein B (sprot)

description: A phage shock protein B that is encoded in the genome of Escherichia coli K-12.


phage shock protein B

A protein that is a translation product of the Escherichia coli K-12 pspB gene or a 1:1 ortholog thereof.


name: NR0B2_RAT Nuclear receptor subfamily 0 group B member 2 (sprot)

description: A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of rat.


name: nuclear receptor subfamily 0 group B member 2 isoform 1 (rat)

description: A nuclear receptor subfamily 0 group B member 2 isoform 1 that is encoded in the genome of rat.


name: TBC1 domain family member 23 isoform 1 (mouse)

description: A TBC1 domain family member 23 isoform 2 that is encoded in the genome of mouse.


name: CDPKU_ARATH Calcium-dependent protein kinase 30 (sprot)

description: A protein that is a translation product of the CPK30 gene in Arabidopsis thaliana.


Omphalorrhexis

description: Rupture of the umbilical cord during labor and delivery.


name: mitogen-activated protein kinase 9 isoform hAlpha-2 (human)

description: A mitogen-activated protein kinase 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P45984-1.


name: MK09_HUMAN Mitogen-activated protein kinase 9 (sprot)

description: A mitogen-activated protein kinase 9 that is encoded in the genome of human.


name: mitogen-activated protein kinase 9 phosphorylated 1 (human)

description: A mitogen-activated protein kinase 9 (human) that has been phosphorylated on the residue at the position equivalent to Thr-183, and phosphotyrosine at position 185 of the amino acid sequence represented by UniProtKB:P45984. UniProtKB:P45984, Thr-183, MOD:00047|Tyr-185, MOD:00048.


name: mitogen-activated protein kinase 9 isoform hBeta-1 (human)

description: A mitogen-activated protein kinase 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P45984-3.


name: mitogen-activated protein kinase 9 isoform Alpha-1 (human)

description: A mitogen-activated protein kinase 9 isoform 2 that is encoded in the genome of human.


name: mitogen-activated protein kinase 9 isoform h5 (human)

description: A mitogen-activated protein kinase 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P45984-5.


name: mitogen-activated protein kinase 9 isoform hBeta-2 (human)

description: A mitogen-activated protein kinase 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P45984-4.


name: AP3B1_MOUSE AP-3 complex subunit beta-1 (sprot)

description: An AP-3 complex subunit beta-1 that is encoded in the genome of mouse.


name: carbohydrate sulfotransferase 13 isoform h1 (human)

description: A carbohydrate sulfotransferase 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NET6-1.


carbohydrate sulfotransferase 13

A protein that is a translation product of the human CHST13 gene or a 1:1 ortholog thereof.


name: CHSTD_HUMAN Carbohydrate sulfotransferase 13 (sprot)

description: A carbohydrate sulfotransferase 13 that is encoded in the genome of human.


name: carbohydrate sulfotransferase 13 isoform h2 (human)

description: A carbohydrate sulfotransferase 13 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NET6-2.


name: voltage-gated potassium channel subunit KCNQ1 sequence variant R190Q (human)

description: A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Gln residue at the position equivalent to Arg-190 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-190, CHEBI:30011.


name: Major Salivary Gland Cancer pNX TNM Finding v6 and v7

description: Major salivary gland cancer in which the regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.)


name: Y4554_ARATH Uncharacterized protein At4g15545 (sprot)

description: A protein that is a translation product of the At4g15545 gene in Arabidopsis thaliana.


protein HdeD

A protein that is a translation product of the Escherichia coli K-12 hdeD gene or a 1:1 ortholog thereof.


HDED_ECOLI Protein HdeD (sprot)

A protein HdeD that is encoded in the genome of Escherichia coli K-12.


name: TOE3_ARATH AP2-like ethylene-responsive transcription factor TOE3 (sprot)

description: A protein that is a translation product of the TOE3 gene in Arabidopsis thaliana.


name: E3 ubiquitin-protein ligase RKP isoform 1 (Arabidopsis thaliana)

description: An E3 ubiquitin-protein ligase RKP (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9SIZ8-1.


name: kinesin-like protein KIF2C cysteinylated 3 (human)

description: A kinesin-like protein KIF2C (human) that has been cysteinylated on the residue at the position equivalent to Cys-344 of the amino acid sequence represented by UniProtKB:Q99661-1. Example: UniProtKB:Q99661-1, Cys-344, MOD:00765.


A trisaccharide consisting of two alpha-D-xylofuranose residues and a D-glucopyranose residue joined in sequence by two (1->3) glycosidic bonds.


name: 60S ribosomal protein L28 isoform 1 (mouse)

description: A large ribosomal subunit protein eL28 isoform 1 that is encoded in the genome of mouse.


name: large ribosomal subunit protein eL28 isoform 1

description: A large ribosomal subunit protein eL28 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46779-1 or a 1:1 ortholog thereof.


name: large ribosomal subunit protein eL28 isoform 1 (human)

description: A large ribosomal subunit protein eL28 isoform 1 that is encoded in the genome of human.


name: collagen alpha-1(XXII) chain, signal peptide removed galactosylhydroxylysine form (human)

description: A collagen alpha-1(XXII) chain (human) that has had the signal peptide removed and that includes at least 1 galactosylhydroxylated lysine. Example: UniProtKB:Q8NFW1-1, 28-1626, MOD:01914.


name: E3 ubiquitin-protein ligase COP1 isoform h4 (human)

description: An E3 ubiquitin-protein ligase COP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NHY2-4.


ribosomal RNA

RNA molecules which are essential structural and functional components of ribosomes, the subcellular units responsible for protein synthesis.


transfer RNA

A single-stranded RNA molecule containing about 70-90 nucleotides, folded by intrastrand base pairing into a characteristic secondary ('cloverleaf') structure that carries a specific amino acid and matches it to its corresponding codon on an mRNA during protein synthesis.


mRNA containing an N(6),2'-O-dimethyladenosine cap.


messenger RNA

An RNA molecule that transfers the coding information for protein synthesis from the chromosomes to the ribosomes mRNA is formed from a DNA template by transcription. It may be a copy of a single gene or of several adjacent genes (polycistronic mRNA). On the ribosome, the sequence is converted into the programmed amino acid sequence through translation.


name: collagen alpha-1(XIV) chain O-glycosylated 10 (human)

description: A collagen alpha-1(XIV) chain (human) that has been O-glycosylated at the residue equivalent to Thr-731 of the amino acid sequence represented by UniProtKB:Q05707-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q05707-1, Thr-731, MOD:00005~GNO:G29068FM.


collagen alpha-1(XIV) chain

A protein that is a translation product of the human COL14A1 gene or a 1:1 ortholog thereof.


name: collagen alpha-1(XIV) chain, signal peptide removed form (human)

description: A collagen alpha-1(XIV) chain (human) that has had the signal peptide removed. Example: UniProtKB:Q05707-1, 29-1796.


name: collagen alpha-1(XIV) chain phosphorylated 1 (human)

description: A collagen alpha-1(XIV) chain (human) that has been phosphorylated on the residue at the position equivalent to Ser-789 of the amino acid sequence represented by UniProtKB:Q05707-1. Example: UniProtKB:Q05707-1, Ser-789, MOD:00046.


name: collagen alpha-1(XIV) chain O-glycosylated 8 (human)

description: A collagen alpha-1(XIV) chain (human) that has been O-glycosylated at the residue equivalent to Thr-727 of the amino acid sequence represented by UniProtKB:Q05707-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:Q05707-1, Thr-727, MOD:00005~GNO:G57317CE.


name: collagen alpha-1(XIV) chain, signal peptide removed glucosylgalactosylhydroxylysine form (human)

description: A collagen alpha-1(XIV) chain (human) that has had the signal peptide removed and that includes at least 1 glucosylgalactosylhydroxylated lysine. Example: UniProtKB:Q05707-1, 29-1796, MOD:00162.