Pitting Edema

description: Swelling due to excessive accumulation of fluid under the skin defined by a persistent indentation when pressure is applied to the swollen area.  Causes include systemic conditions (e.g., heart failure, liver failure, or kidney failure) and local conditions affecting the extremities.


name: Supraglottic Cancer pNX TNM Finding v6 and v7

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Supraglottic cancer in which the regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.)


name: Other Specified Diabetes Mellitus with Proliferative Diabetic Retinopathy without Macular Edema, Right Eye

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Evidence of other specified diabetes mellitus with proliferative diabetic retinopathy without macular edema in the right eye not specified elsewhere.


Grade 1 Bronchospasm, CTCAE

description: Mild symptoms; intervention not indicated


name: Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Site

description: Evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified site.


name: Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative

description: A category of juvenile idiopathic arthritis defined by the presence of arthritis affecting five or more separate joints during the first six months of disease, with negative serologic testing for rheumatoid factor.


name: Childhood L1 Acute Lymphoblastic Leukemia

description: L1 acute lymphoblastic leukemia that occurs during childhood.


Neoplasm of lacrimal duct

description: A benign or malignant neoplasm that affects the lacrimal duct.


Sickle Beta Plus Thalassemia

description: A mild form of sickle cell thalassemia characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells. It is characterized by the presence of small red blood cells and mild anemia.


name: Grade 4 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Delayed Orgasm, CTCAE

description: Delay in achieving orgasm not adversely affecting relationship


name: Refractory Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma, not otherwise specified, that is resistant to treatment.


name: Recurrent Anaplastic (Malignant) Meningioma

description: The reemergence of anaplastic (malignant) meningioma after a period of remission.


Grade 3 Arteritis Infective, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 1 Non-Infectious Wound Complication, CTCAE


Urostomy Stenosis, CTCAE

description: A finding of narrowing of the opening of a urostomy.


Nodule Consistency

description: A description about the radiologic consistency of a nodule.


name: Metabolic or Respiratory Alkalosis, CTCAE


name: Unspecified Malignant Neoplasm Skin of Right Lower Limb, Including Hip

description: Evidence of unspecified malignant neoplasm skin of the right lower limb including the hip.


Hypopituitarism, CTCAE

description: A disorder characterized by a decrease in production of hormones from the pituitary gland.


Biclonal gammopathy

description: A primary disturbance in immunoglobulin synthesis characterized by the presence of two distinct monoclonal immunoglobulins in the serum or urine.


Thymic Tumor pN2 TNM Finding v8

description: Thymic tumor with metastasis in deep intrathoracic or cervical lymph nodes. (from AJCC 8th Ed.)


name: Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Unspecified, Intrapelvic Lymph Nodes

description: Evidence of an unspecified mature T-cell and NK-cell non-Hodgkin lymphoma in the intrapelvic lymph nodes.


Sarcoma of the Orbit cM0 TNM Finding v7

description: Sarcoma of the orbit without evidence of distant metastasis. (from AJCC 7th Ed.)


name: Other specified malignant neoplasm of skin of left upper eyelid, including canthus

description: Evidence of other specified malignant neoplasm of skin of left upper eyelid including the canthus not specified elsewhere.


Vaccination Site Lymphadenopathy, CTCAE

description: A disorder characterized by lymph node enlargement after vaccination


name: Prostate Cancer pT2 TNM Finding v6 and v7

description: Prostate cancer confined to the prostate gland. (from AJCC 6th and 7th Eds.)


name: Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Colon or Rectum Neuroendocrine Tumor pT1 TNM Finding v7

description: Colon or rectum neuroendocrine tumor invading lamina propria or submucosa and is 2 cm or less in size. (from AJCC 7th Ed.)


name: Mycosis Fungoides and Sezary Syndrome Primary Tumor TNM Finding v8

description: A finding about one or more characteristics of mycosis fungoides and Sezary syndrome, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor (skin).


name: Prostatic Urethra Cancer pT3 TNM Finding v8

description: Urethral cancer with tumor invading the periprostatic fat. (from AJCC 8th Ed.)


name: Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of nasopharyngeal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.  The distribution and the prognostic impact of regional lymph node spread from nasopharynx cancer, particularly of the undifferentiated type, are different from those of other head and neck mucosal cancers and justify the use of a different N classification scheme. (from AJCC 7th Ed.)


Cyst of biliary tract

description: A cystic dilatation that occurs in any part of the biliary tree.


Gastric Cancer pN3b TNM Finding v7

description: Gastric cancer with metastasis in sixteen or more regional lymph nodes. (from AJCC 7th Ed.)


Malignant Lymphoma, Large Cell Type

description: An antiquated term that refers to a morphologic variant of non-Hodgkin lymphoma which is composed predominantly or exclusively of large neoplastic lymphocytes.


Decreased NCF4 Expression

description: An indication that the expression of NCF4 is lower than the normal range of values.


Grade 5 Stridor, CTCAE

description: Death


name: Diabetes Mellitus due to Underlying Condition with Other Circulatory Complication

description: Evidence of diabetes mellitus due to underlying condition with other circulatory complication.


name: Pre-Existing Type 1 Diabetes Mellitus, in Pregnancy, Second Trimester

description: Evidence of pre-existing type 1 diabetes mellitus in the in pregnancy in the second trimester.


name: Atherosclerosis of Non-Autologous Biological Bypass Graft(s) of Extremity with Ulceration

description: Evidence of atherosclerosis of non-autologous biological bypass graft(s) of extremity with ulceration.


name: Grade 5 Spermatic Cord Stricture or Stenosis, CTCAE


Rheumatoid nodule, multiple sites

description: Evidence of rheumatoid nodule in multiple sites.


Half Field-of-view Ghost Artifact

description: A characteristic artifact (ghost) which is shifted with respect to the main image by a half-field of view, resulting from a mismatch in either the amplitude or phase between odd and even echoes.


name: Grade 1 Spermatic Cord Stricture or Stenosis, CTCAE


Grade 4 Stoma Site Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Coke Oven Emission Exposure

description: Occupational exposure to gases and particulates produced when coal is processed in a coke oven.


name: Grade 4 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Supraglottic Cancer pM0 TNM Finding

description: Supraglottic cancer with no distant metastasis. (from AJCC 6th Ed.)


Grade 4 Bladder Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 3 Dyspepsia, CTCAE

description: Severe symptoms; operative intervention indicated


name: Adverse Event Associated with Metabolic and Laboratory Abnormalities


Grade 2 Hot Flashes, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Colon or Rectum Neuroendocrine Tumor pT4 TNM Finding v7

description: Colon or rectum neuroendocrine tumor invading peritoneum or other organs. (from AJCC 7th Ed.)


Melanoma of the Uvea cM0 TNM Finding v7

description: Melanoma of the uvea in which regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


Grade 4 Acidosis, CTCAE

description: Life-threatening consequences


name: Mucosal Melanoma of the Head and Neck pM1 TNM Finding v8

description: Mucosal melanoma of the head and neck with distant metastasis. (from AJCC 8th Ed.)


name: Type 2 Diabetes Mellitus with Severe Nonproliferative Diabetic Retinopathy without Macular Edema, Unspecified Eye

description: Evidence of type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema in an unspecified eye.


PSA Level Greater than Two

description: A blood concentration of prostate specific antigen greater than 2 ng/mL.


RET Gene Alteration Negative

description: An indication that mutation, overexpression, fusion or rearrangement involving the RET gene has not been detected in a sample.


Grade 3 Otitis Externa, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Oropharyngeal Cancer TNM Finding v7

description: A finding about one or more characteristics of oropharyngeal cancer, following the rules of the TNM AJCC v7 classification system.


name: Grade 4 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Fall, CTCAE

description: Hospitalization indicated; invasive intervention indicated


name: Sarcoma of the Orbit Clinical Distant Metastasis TNM Finding v7

description: A clinical finding about one or more characteristics of sarcoma of the orbit, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.


name: Major Salivary Gland Cancer pN2 TNM Finding V8

description: Major salivary gland cancer with metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(+); or more than 3 cm but not more than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-), or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


Vaginal Cancer pN1 TNM Finding v8

description: Vaginal cancer with pelvic or inguinal lymph node metastasis. (from AJCC 8th Ed.)


Bladder Sphincter Dysfunction

description: Non-coordinated, reflexive contraction of the bladder and sphincter relaxation.


Incidental Finding

description: An abnormality noted on diagnostic testing that was not related to the reason that prompted the analysis.


Grade 1 Pain, CTCAE

description: Mild pain


Injury of lumbar spinal cord

description: An injury to the lumbar spinal cord.


Grade 1 Dysarthria, CTCAE

description: Mild slurred speech


name: Occlusion and stenosis of other precerebral artery

description: Evidence of occlusion and stenosis of other precerebral arteries.


name: Breast Cancer Clinical Primary Tumor TNM Finding v6

description: A clinical finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of the primary tumor.


Cervical Cancer Clinical TNM Finding v9

description: A clinical finding about one or more characteristics of cervical cancer, following the rules of the TNM AJCC v9 classification system.


name: Grade 2 Cranial Nerve XII Intra-Operative Injury, CTCAE


name: Ocular Adnexal Lymphoma pN1b TNM Finding v8

description: Ocular adnexal lymphoma with involvement of two or more lymph node regions, superior to the mediastinum. (from AJCC 8th Ed.)


Congenital supraventricular tachycardia

description: A disorder present at birth characterized by an electrocardiographic finding of a tachycardia that originates above the ventricles.


Grade 5 Wound Complication, CTCAE

description: Death


Refractory Malignant Bone Neoplasm

description: Malignant bone neoplasm that is resistant to treatment.


name: Esophagus and Esophagogastric Junction Cancer Pathologic Regional Lymph Nodes TNM Finding v8

description: A pathologic finding about one or more characteristics of esophagus and esophagogastric junction cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.


name: Type 2 Diabetes Mellitus with Proliferative Diabetic Retinopathy with Traction Retinal Detachment Involving the Macula, Bilateral

description: Evidence of type 2 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula that is bilateral.


name: Embolism and thrombosis of the thoracic aorta

description: Evidence of embolism and thrombosis of thoracic aorta.


name: Invasive Microcystic Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by microcysts formation.


name: Grade 2 Intraoperative Arterial Injury, CTCAE

description: Partial resection of injured organ/structure indicated


name: Stage IVA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Gallbladder Papillary Adenoma

description: An adenoma that arises from the gallbladder.  It is characterized by the presence of a papillary growth pattern.


name: Grade 3 Personality and Behavioral Change, CTCAE


name: Unspecified Juvenile Rheumatoid Arthritis, Right Hip

description: Evidence of unspecified juvenile rheumatoid arthritis in the right hip.


Ibrutinib Resistance

description: A finding indicating that chronic lymphocytic leukemia does not respond to treatment with Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib.


name: Leiomyosarcoma and Endometrial Stromal Sarcoma pN0 TNM Finding v7

description: No regional lymph node metastasis. (from AJCC 7th Ed.)


Recurrent Aplastic Anemia

description: The reemergence of aplastic anemia after a period of remission.


name: Developmental and Epileptic Encephalopathy 9

description: An X-linked subtype of developmental and epileptic encephalopathy caused by mutation(s) in the PCDH19 gene, encoding protocadherin-19.


name: Grade 2 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Rash Hand or Foot Skin Reaction, CTCAE


name: Other Specified Diabetes Mellitus with Proliferative Diabetic Retinopathy with Traction Retinal Detachment Involving the Macula, Right Eye

description: Evidence of other specified diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula in the right eye not specified elsewhere.


name: Unspecified Malignant Neoplasm Skin of Unspecified Lower Limb, Including Hip

description: Evidence of unspecified malignant neoplasm skin of unspecified lower limb including the hip.


name: Vaginal Mucinous Adenocarcinoma, Gastric-Type

description: Vaginal mucinous adenocarcinoma characterized by the presence of gastric differentiation.


name: Aromatic Dyes-Related Malignant Neoplasm


MSH2 Negative

description: An indication that expression of MSH2 has not been detected in a sample.


Childhood Glioblastoma

description: A glioblastoma that occurs during childhood.


Childhood Low Grade Fibromyxoid Sarcoma

description: A low-grade fibromyxoid sarcoma that occurs during childhood.


name: Precursor T-lymphoblastic lymphoma/leukemia stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (Rare in Hodgkin lymphoma).


name: Nasopharyngeal Cancer Clinical Distant Metastasis TNM Finding v8

description: A clinical finding about one or more characteristics of nasopharyngeal cancer, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Diabetes Mellitus due to Underlying Condition with Unspecified Complication

description: Evidence of diabetes mellitus due to underlying condition with unspecified complication.


name: Adult Primary Meningeal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the leptomeninges and occurs during adulthood.


name: Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma pT3b TNM Finding v8

description: Uterine corpus leiomyosarcoma or endometrial stromal sarcoma with tumor infiltrating abdominal tissues at more than one site. (from AJCC 8th Ed.)


name: Radiating Chest Pain Along Left Anterior Axillary Line

description: The location of the radiating chest pain is along the left anterior axillary line.


name: Drug or Chemical Induced Diabetes Mellitus with Other Specified Complication

description: Evidence of drug or chemical induced diabetes mellitus with other specified complication.


name: Urothelial (Transitional Cell) Carcinoma of the Prostate pT1 TNM Finding v7

description: Urothelial (transitional cell) carcinoma of the prostate with tumor invading urethral subepithelial connective tissue. (from AJCC 7th Ed.)


Lung Cancer Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of lung cancer, following the rules of the TNM AJCC v8 classification system.


Stage II Prostate Cancer AJCC v6

description: Stage II includes: (T1a, N0, M0, G2, 3-4); (T1b, N0, M0, Any G); (T1c, N0, M0, Any G); (T1, N0, M0, Any G); (T2, N0, M0, Any G).  T1: Clinically inapparent tumor neither palpable nor visible by imaging.  T1a: Tumor incidental histologic finding in 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g. because of elevated PSA).  T2: Tumor confined with in the prostate.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G2: Moderately differentiated (moderate anaplasia) (Gleason 5-6). G 3-4: Poorly differentiated/undifferentiated (marked anaplasia) (Gleason 7-10).  (AJCC 6th ed.)


name: Supraglottic Cancer pN2c TNM Finding v6 and v7

description: Supraglottic cancer with metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. (from AJCC 6th and 7th Eds.)


Grade 4 Vomiting, CTCAE

description: Life-threatening consequences


Treatment related leukaemia

description: A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation.


Fungal Colonization

description: Collection of fungal organisms in an anatomic site or medical device.


name: Grade 3 Neutrophils and Granulocytes, CTCAE


name: Carcinoma in Situ of Skin of Right Ear and External Auricular Canal

description: Evidence of carcinoma in situ of the skin of right ear and external auricular canal.


Grade 3 Perineal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Nasal Cavity and Ethmoid Sinus Cancer pT4b TNM Finding v6

description: Nasal cavity and ethmoid sinus cancer with tumor invading any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than the maxillary division of the trigeminal nerve, nasopharynx, or clivus. (from AJCC 6th Ed.)


name: Grade 4 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Prostate Cancer Pathologic Distant Metastasis TNM Finding v8

description: A pathologic finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Grade 1 Retina Intra-Operative Injury, CTCAE


name: Atherosclerosis of Autologous Vein Bypass Graft(s) of the Extremities with Rest Pain, Other Extremity

description: Evidence of atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain in another extremity.


name: Grade 4 Non-Malignant Pericardial Effusion, CTCAE


Cutaneous Melanoma pT2a TNM Finding v8

description: Cutaneous melanoma measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. (from AJCC 8th Ed.)


New Lesion Progression

description: An assessment of the equivocality of disease progression based on a newly identified lesion.


name: Direct Infection of Left Hip in Infectious and Parasitic Diseases Classified Elsewhere

description: Evidence of direct infection of left hip in infectious and parasitic diseases classified elsewhere.


name: Grade 1 Cardiac Troponin I Increased, CTCAE

description: Levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer


Bladder Cancer pN2 TNM Finding v7

description: Bladder cancer with multiple regional lymph node metastases in the true pelvis (hypogastric, obturator, external iliac, or presacral lymph node metastasis).  (from AJCC 7th Ed.)


Cervical Cancer pT1a2 TNM Finding v9

description: Invasive cervical carcinoma with measured stromal invasion of more than 3.0 mm and equal or less than 5.0 mm in depth. (from AJCC 9th Ed.)


dissection of lower extremity artery

description: Evidence of dissection of artery of lower extremity.


Trochlear Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the trochlear nerve (fourth cranial nerve).


Testosterone Less than 300 ng/dL

description: A semiquantitative finding indicating that the concentration of testosterone in a sample is less than 300 ng/dL.


name: Grade 2 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Adult Grade II Meningioma

description: A grade II meningioma that occurs during adulthood.


name: Appendix High Grade Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix.  It is characterized by the presence of moderate or severe dysplasia and complex architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


name: Metastatic Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Grade 3 Lymphocele, CTCAE

description: Severe symptoms; invasive intervention indicated


Serum CA 19-9 Elevated

description: The amount of cancer antigen 19-9 present in a serum sample is elevated.


name: Gastric Neuroendocrine Tumor cM1b TNM Finding v8

description: Gastric neuroendocrine tumor with metastasis in at least one extrahepatic site (e.g., lung, ovary, nonregional lymph node, peritoneum, bone). (from AJCC 8th Ed.)


opioid abuse - uncomplicated

description: Evidence of opioid abuse, uncomplicated.


name: Grade 2 Anal Sphincter Intra-Operative Injury, CTCAE


name: Follicular Lymphoma, Unspecified, Lymph Nodes of Head, Face, and Neck

description: Evidence of unspecified follicular lymphoma in the lymph nodes of head, face, and neck.


name: Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Bladder Cancer Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of bladder cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Verrucous carcinoma of the oral cavity stage III


name: Major Salivary Gland Cancer cN2b TNM Finding V8

description: Major salivary gland cancer with metastasis in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)


name: Grade 3 Otitis Middle Ear Non Infectious, CTCAE


name: Malignant Neoplasm of Central Portion of Unspecified Female Breast

description: Evidence of a malignant neoplasm of the central portion of unspecified female breast.


Conjunctival Junctional Nevus

description: A junctional nevus that arises from the conjunctiva. It occurs almost exclusively in the juxtalimbal bulbar conjunctiva. It is characterized by an intraepithelial proliferation of type A nevus cells and/ or type B nevus cells.


name: Grade 4 Intraoperative Splenic Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade III Childhood Astrocytoma

description: An anaplastic astrocytoma that arises from the central nervous system and occurs during childhood.


name: Nasopharyngeal Cancer pT2a TNM Finding v6

description: Nasopharyngeal cancer with tumor extending into the oropharynx and/or nasal cavity without parapharyngeal extension. (from AJCC 6th Ed.)


name: Locally Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Anal Ulcer, CTCAE

description: Symptomatic; altered GI function


name: Breast Cancer pT4b TNM Finding v6 and v7

description: Breast cancer with ulceration and/or ipsilateral satellite nodules and/or edema (including peau d'orange) of the skin, which do not meet the criteria for inflammatory carcinoma. (from AJCC 6th and 7th Eds.)


name: Other Rheumatoid Arthritis with Rheumatoid Factor of Other Specified Site

description: Evidence of other rheumatoid arthritis with rheumatoid factor of other specified site not specified elsewhere.


name: Rheumatoid Arthritis with Rheumatoid Factor of Left Wrist without Organ or Systems Involvement

description: Evidence of rheumatoid arthritis with rheumatoid factor of left wrist without organ or systems involvement.


name: Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder

description: A clonal T-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed T-lymphocytes/NK-cells.  The clonal cellular infiltrates fulfill the criteria for any of the T-cell or natural killer cell lymphomas.


Grade 3 Renal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 2 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Esophageal and Gastroesophageal Junction Carcinoma

description: A carcinoma that arises from the esophagus or gastroesophageal junction.


name: Conjunctival Carcinoma pTX TNM Finding v8

description: Conjunctival carcinoma in which the primary tumor cannot be assessed. (from AJCC 8th Ed.)


name: Grade 4 Small Bowel Stricture or Stenosis NOS, CTCAE


name: Soft Tissue Sarcoma of the Head and Neck pT2 TNM Finding v8

description: Soft tissue sarcoma of the head and neck with tumor measuring more than 2 cm but 4 cm or less in greatest dimension. (from AJCC 8th Ed.)


name: Retinoblastoma Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of retinoblastoma, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.


name: Other Reactive Arthropathies, Unspecified Elbow

description: Evidence of other reactive arthropathies in an unspecified elbow not specified elsewhere.


Grade 2 Endophthalmitis, CTCAE

description: Local intervention indicated


name: Grade 4 Scleral Necrosis and Melt, CTCAE


De Novo Nodular Melanoma

description: A nodular melanoma that does not arise from a nevus and lacks a radial growth phase.


name: Grade 2 Salivary Duct Inflammation, CTCAE

description: Thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL


name: Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps), CTCAE


name: Grade 5 Small Intestinal Stenosis, CTCAE

description: Death


name: Mycosis fungoides involving lymph nodes of inguinal region and lower limb

description: Evidence of mycosis fungoides, lymph nodes of inguinal region and lower limb.


Bladder Cancer pT4b TNM Finding v8

description: Bladder cancer with extravesical tumor invading pelvic wall, abdominal wall. (from AJCC 8th Ed.)


name: epilepsy, idiopathic generalized, susceptibility to, 15

description: An autosomal dominant susceptibility to idiopathic generalized epilepsy-15, caused by mutation(s) in the RORB gene, encoding nuclear receptor ROR-beta. The condition is characterized by early-onset generalized seizures and may have associated developmental delay.


Grade 3 Bone Marrow Hypocellular, CTCAE

description: Severely hypocellular or >50-<=75% reduction cellularity from normal for age


name: Other non-follicular lymphoma, intra-abdominal lymph nodes

description: Evidence of other non-follicular lymphoma in the intra-abdominal lymph nodes not specified elsewhere.


Fibrinous Material Present

description: A finding indicating the presence of fibrinous material in a surgical pathology specimen.


name: Juvenile arthritis, unspecified, site unspecified

description: Evidence of unspecified juvenile arthritis in the site.


name: Grade 4 Slipped Capital Femoral Epiphysis, CTCAE


Grade 4 Gastric Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Refractory Squamous Cell Carcinoma

description: Squamous cell carcinoma that is resistant to treatment.


name: Follicular Lymphoma Grade I, Intrapelvic Lymph Nodes

description: Evidence of follicular lymphoma grade I in the intrapelvic lymph nodes.


name: Thyroid Cancer pN1a TNM Finding v6 and v7

description: Thyroid cancer with metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). (from AJCC 6th and 7th Eds.)


Congenital Adrenal Gland Disorder

description: A genetic disorder that affects the adrenal gland.  It includes adrenal gland hyperplasia and adrenal gland hypoplasia.


Non-Neoplastic Gonadal Disorder

description: A non-neoplastic disorder that affects the testis or the ovary. Representative examples include gonadal agenesis, dysgenesis, and hypogonadism.


name: Uterine Corpus Adenosarcoma cM0 TNM Finding v8

description: Uterine corpus adenosarcoma without evidence of distant metastasis. (from AJCC 8th Ed.)


name: Hemoglobin Beta Heterozygous Insufficiency Genotype

description: A genetic finding indicating that one copy of chromosome 16 has a functional copy (B) of the hemoglobin beta gene (HBB) and the other copy has HBB mutations that lead to hemoglobin subunit beta insufficiency (B+). This genotype is associated with beta thalassemia minor.


name: Grade 5 Neonatal Respiratory Distress Syndrome, AE

description: A respiratory distress adverse event in a newborn which results in death.


name: Stage IV Renal Pelvis and Ureter Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


name: Lower Gastrointestinal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).


name: Melanoma in Situ of Right Ear and External Auricular Canal

description: Evidence of melanoma in situ of right ear and external auricular canal.


name: Major Depressive Disorder, Recurrent, in Remission, Unspecified

description: Evidence of major depressive disorder that is recurrent and in remission.


name: Acute Cardiovascular Complications Related to COVID-19

description: Acute cardiovascular complications occurring in association with SARS-CoV-2 infection.


name: Thoracic aortic aneurysm without rupture

description: Evidence of thoracic aortic aneurysm, without rupture.


Normal Precordial Palpation Finding

description: A clinical finding in which palpation of the chest wall anterior to the heart reveals normal location and characteristic of the right ventricular and apical impulses without other palpable impulses. (ACC/AHA)


Complications of transplanted heart

description: A disease or disorder that is associated with a transplanted heart.


description: Evidence of post-immunization arthropathy in the vertebrae.


name: Grade 4 Muscle Intra-Operative Injury, CTCAE


name: Grade 1 Pancreatic Enzymes Decreased, CTCAE

description: <LLN and asymptomatic


name: Grade 4 Intraoperative Arterial Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Single-Copy Loss

description: A finding indicating the loss of one copy of a gene or genetic/genomic segment in a sample.


name: Esophagus and Esophagogastric Junction Cancer pTX TNM Finding v8

description: Esophagus and esophagogastric junction cancer in which the primary tumor cannot be assessed. (from AJCC 8th Ed.)


Invasive Prostate Carcinoma

description: A carcinoma that is not confined to the prostatic epithelium but has spread to the surrounding stroma of the prostate gland.  The vast majority of invasive prostate carcinomas are adenocarcinomas.


Grade 2 Conjunctivitis Infective, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Retroperitoneal disorder

description: A non-neoplastic or neoplastic disorder that affects the retroperitoneum.


Kidney Cancer pT4 TNM Finding v6

description: Kidney cancer with tumor extending beyond Gerota's fascia. (from AJCC 6th Ed.)


Non-Neoplastic Anal Disorder

description: A non-neoplastic disorder that affects the anus. Representative examples include hemorrhoids, ulcers, and infections.


Ileus, CTCAE

description: A disorder characterized by failure of the ileum to transport intestinal contents.


name: Grade 2 Gastrointestinal Stoma Leak, CTCAE


Grade 1 Chronic Kidney Disease, CTCAE

description: eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN-60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5


Vaginal Cancer pN0 TNM Finding v8

description: Vaginal cancer with no regional lymph node metastasis. (from AJCC 8th Ed.)


name: Grade 2 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

description: 6-8 units below LLN; for follow-up, an asymptomatic decrease of >5-8 units (ml/min/mm Hg) below the baseline value; symptomatic and intervention not indicated


Grade 4 Delusions, CTCAE

description: Life-threatening consequences, threats of harm to self or others; hospitalization indicated


FBXW7 Gene Mutation Negative

description: A genetic finding indicating that FBXW7 gene mutations have not been detected in a sample.


name: Grade 2 Uterus Intra-Operative Injury, CTCAE


Methylene Chloride Exposure

description: A finding indicating that an individual has been exposed to methylene chloride.


name: Grade 5 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Malignant Neoplasm of Axillary Tail of Right Male Breast

description: Evidence of a malignant neoplasm of the axillary tail of right male breast.


Global Progressive Disease in Skin

description: 25 percent or greater increase in skin disease from baseline; or new tumors (T3) in patients with T1, T2, or T4 only skin disease; or loss of response: in those with complete or partial response, increase of skin score of greater than the sum of nadir plus 50 percent baseline score.


name: Unspecified Juvenile Rheumatoid Arthritis, Vertebrae

description: Evidence of unspecified juvenile rheumatoid arthritis in the vertebrae.


name: Grade 3 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Personality and Behavioral Change, CTCAE


name: Drug or Chemical Induced Diabetes Mellitus with Proliferative Diabetic Retinopathy with Combined Traction Retinal Detachment and Rhegmatogenous Retinal Detachment, Unspecified Eye

description: Evidence of drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with combined traction retinal detachment and rhegmatogenous retinal detachment in an unspecified eye.


name: Clear Cell Tumor with Melanocytic Differentiation and ACTG1-MITF Translocation

description: A clear cell tumor with melanocytic differentiation characterized by a cytogenetic translocation between ACTG1 and MITF genes that results in ACTG1-MITF gene fusion.


N4 TNM Finding

description: A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes. The definition of N4 TNM finding depends on the specific type of cancer that it refers to; for example, for ocular adnexal lymphoma it refers to metastases to central lymph nodes.


Grade 2 Suicidal Ideation, CTCAE

description: Suicidal ideation with no specific plan or intent


name: Maxillary Sinus Cancer Pathologic Primary Tumor TNM Finding v6

description: A pathologic finding about one or more characteristics of maxillary sinus cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of the primary tumor.


name: Benign Accessory Urethral Gland Neoplasm

description: A neoplasm that arises from the accessory urethral glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Trigeminal Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the trigeminal nerve (fifth cranial nerve).


name: Other Disease of Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism Complicating Pregnancy, First Trimester

description: Evidence of other disease of blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy in the first trimester not specified elsewhere.


name: Grade 4 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


name: Grade 1 Testes Stricture or Stenosis, CTCAE


Grade 5 Gastric Perforation, CTCAE

description: Death


name: Genitourinary Stoma Stricture or Stenosis, CTCAE


name: Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Gastrointestinal Stromal Tumor pTX TNM Finding v8

description: Gastrointestinal stromal tumor in which the primary tumor cannot be assessed. (from AJCC 8th Ed.)


Childhood Ependymal Tumor

description: An ependymal tumor that occurs during childhood.


name: Recurrent Fallopian Tube High Grade Serous Adenocarcinoma

description: The reemergence of fallopian tube high-grade serous adenocarcinoma after a period of remission.


Grade 1 Nipple Deformity, CTCAE

description: Asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex


Stage II Anal Cancer AJCC v8

description: Stage II includes: IIA: T2, N0, M0; IIB: T3, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Pancreatic Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage M2 Childhood Ependymoma by Toronto Guidelines v2

description: Visible metastasis in brain. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Aggressive Prostate Adenocarcinoma

description: Prostate adenocarcinoma that metastasizes quickly to other anatomic sites. It usually has a Gleason score between 8 and 10, a PSA level higher than 20 ng/ml, and is classified as T3b or T4.


name: Stage IVC Oral Cavity Verrucous Carcinoma


Extracted Lead

description: The lead has been removed from the body.


name: Grade 3 Neonatal Respiratory Distress Syndrome, AE

description: An adverse event in a newborn characterized by clinical evidence of increased respiratory distress with relevant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); requiring major care change (e.g. starting invasive support).


Mismatch at One HLA Allele

description: One allele matches for one HLA locus.


name: Autosomal Dominant Congenital Myopathy-1A

description: An autosomal dominant condition caused by mutation(s) in the RYR1 gene, encoding ryanodine receptor 1. The phenotype is variable, but generally includes weakness in the proximal muscles of the lower limb and individuals are at increased risk for malignant hyperthermia.


name: Breast Cancer pN0(mol-) TNM Finding v6 and v7

description: Breast cancer without histological evidence of regional lymph node involvement, and with negative molecular findings by RT-PCR. (from AJCC 6th and 7th Ed.)


Kidney Neuroendocrine Neoplasm

description: An epithelial neoplasm with neuroendocrine differentiation that arises from the kidney.  It includes neuroendocrine tumor, small cell neuroendocrine carcinoma, large cell neuroendocrine carcinoma, and paraganglioma.


PSA Level Less than 0.2

description: A blood concentration of prostate specific antigen less than 0.2 ng/mL.


Urinary Tract Cancer TNM Finding v8

description: A finding about one or more characteristics of urinary tract cancer, following the rules of the TNM AJCC v8 classification system.


Increased Therapeutic Response

description: An increase in the desirable and beneficial effects resulting from a medical  treatment.


Cancer-Associated Anorexia

description: Loss of appetite associated with cancer or its treatment.


Locally Advanced Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Intrahepatic Bile Duct Cancer Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of intrahepatic bile duct cancer, following the rules of the TNM AJCC v7 classification system.  Complete pathologic staging consists of evaluation of the primary tumor, including tumor number, involvement of local regional lymph nodes, and the presence or absence of vascular invasion. (from AJCC 7th Ed.)


name: Rheumatoid Arthritis of Right Elbow with Involvement of Organs and Systems

description: Evidence of rheumatoid arthritis of right elbow with involvement of organs and systems.


Chronic Right Heart Failure

description: Persistent and long-standing right heart failure.


name: Mycosis Fungoides and Sezary Syndrome B1b TNM Finding v8

description: Clone positive. Note: A T-cell clone is defined by polymerase chain reaction (PCR) or Southern blot analysis of the TCR gene. (from AJCC 8th Ed.)


name: Other Reactive Arthropathies, Right Wrist

description: Evidence of other reactive arthropathies in the right wrist not specified elsewhere.


Grade 5 Esophageal Obstruction, CTCAE

description: Death


name: Diabetes Mellitus due to Underlying Condition with Proliferative Diabetic Retinopathy with Macular Edema, Unspecified Eye

description: Evidence of diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema in an unspecified eye.


name: Grade 1 Renal and Urinary Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Advanced Mucosal Melanoma

description: Mucosal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pruritus, CTCAE

description: Widespread and constant; limiting self care ADL or sleep; systemic corticosteroid or immunosuppressive therapy indicated


name: Metastatic malignant neoplasm to peritoneum

description: The spread of a malignant neoplasm to the peritoneum from another primary anatomic site.


name: Grade 1 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 2 Bladder Spasm, CTCAE

description: Antispasmodics indicated


Grade 3 Hallucinations, CTCAE

description: Severe hallucinations; hospitalization not indicated


name: Spine Cancer Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of spine cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.


Sub-therapeutic Drug Level

description: A drug serum concentration below therapeutic levels.


name: Type 2 Diabetes Mellitus with Diabetic Neuropathy, Unspecified

description: Evidence of type 2 diabetes mellitus with diabetic neuropathy.


name: Grade 4 Ureteric Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Appendiceal Carcinoma pTis TNM Finding v7

description: Appendiceal carcinoma with a finding of carcinoma in situ: intraepithelial or invasion of the lamina propria.  Tis includes cancer cells confined within the glandular basement membrane (intraepithelial) or lamina propria (intramucosal) with no extension through muscularis mucosae into submucosa. (from AJCC 7th Ed.)


description: Evidence of hallucinogen abuse with hallucinogen-induced psychotic disorder with delusions.


Disease Response

description: The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression.


name: Other Paralytic Syndrome following Cerebral Infarction Affecting Right Dominant Side

description: Evidence of other paralytic syndrome following cerebral infarction affecting right dominant side not specified elsewhere.


name: Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Cervical Stratified Mucin-Producing Intraepithelial Lesion

description: A rare, human papillomavirus-associated premalignant glandular intraepithelial neoplasm that arises from the cervix. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin. There is no evidence of stromal invasion. It is distinct from conventional cervical squamous or glandular intraepithelial neoplasias.


Metanephric Tumor

description: A neoplasm arising from the distal convoluted tubule and collecting duct areas of the kidney.


name: Nasopharyngeal Cancer pT1 TNM Finding v7

description: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor.  (from AJCC 7th Ed.)


Localized Neoplasm

description: A neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Other psoriatic arthropathies

description: Evidence of other psoriatic arthropathy not specified elsewhere.


Grade 5 Proctitis, CTCAE

description: Death


Complication of transplant

description: A problem arising from transplantation.


COVID-19-Associated Hematuria

description: Hematuria caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Benign neuroendocrine tumor

description: A paraganglioma that is confined to the site of origin.


name: Subclinical iodine deficiency hypothyroidism

description: Evidence of subclinical iodine-deficiency hypothyroidism.


Lichenoid Actinic Keratosis

description: Actinic keratosis characterized by the presence of a band-like chronic inflammatory infiltrate in the papillary dermis and vacuolar changes in the basal keratinocytes.


hallucinogen dependence - uncomplicated

description: Evidence of hallucinogen dependence, uncomplicated.


name: Merkel Cell Carcinoma of Unspecified Upper Limb, Including Shoulder

description: Evidence of Merkel cell carcinoma of unspecified upper limb including the shoulder.


Continent Epispadias

description: Epispadias with urinary continence.


name: Therapy-Related Toxicity - Acceptable to Patient

description: Indicates that a toxicity adverse effect has been experienced by a patient, but it is not severe enough for the patient to discontinue the treatment.


name: Ann Arbor Stage I Supradiaphragmatic Hodgkin Lymphoma


Serosal Lesion

description: A lesion that is located in the serosa surface of an organ.


Copy Number Loss

description: A finding indicating the detection of less than the normal number of copies of a gene or genetic/genomic segment in a sample.


Breast Cancer pT3 TNM Finding v6 and v7

description: Breast cancer with tumor size more than 5.0 cm in greatest dimension. (from AJCC 6th and 7th Eds.)


Global Complete Response in Skin

description: 100 percent clearance of skin lesions.


name: stenosis of supravalvular pulmonary artery

description: Stenosis of the pulmonary artery that occurs above the valve.


name: Cognitive Social or Emotional Deficit following Other Cerebrovascular Disease

description: Evidence of cognitive social or emotional deficit following other cerebrovascular disease.


name: Grade 4 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 2 Periorbital Edema, CTCAE

description: Indurated or pitting edema; topical intervention indicated


name: Occlusion and Stenosis of Left Posterior Cerebral Artery

description: Evidence of occlusion and stenosis of left posterior cerebral artery.


Grade 2 Anorectal Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Grade 3 Lower Extremity Soft Tissue Necrosis, CTCAE


Post-Surgical Complication

description: A disease or disorder that occurs soon after or as a result of a surgical procedure.


Abscess of adrenal gland

description: An abscess that is located in the adrenal gland.


name: Right Posterolateral Apical Peripheral Zone of Prostate

description: The region of the prostate that is located on the anatomical right side of the posterolateral portion of the apical division of the peripheral zone.


name: Drug or Chemical Induced Diabetes Mellitus with Moderate Non-Proliferative Diabetic Retinopathy without Macular Edema, Right Eye

description: Evidence of drug or chemical induced diabetes mellitus with moderate non-proliferative diabetic retinopathy without macular edema in the right eye.


name: Acute Erythroid Leukemia not Having Achieved Remission

description: Evidence of acute erythroid leukemia not having achieved remission.


Stage I Esophageal Cancer

description: Stage I includes: T1, N0, M0.  TI: Tumor invades lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) -2003


name: Grade 4 Cecum Intra-Operative Injury, CTCAE


name: Grade 4 Encephalomyelitis Infection, CTCAE


name: Grade 5 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Enteropathic spondylitis

description: A form of spondyloarthritis that is found in some patients with inflammatory bowel disease.


Smokehouse Smoke Exposure

description: Environmental, occupational or consumer-based exposure to airborne gases and particulates produced during indoor smoke curing of food products.


Neck Edema

description: Swelling due to an accumulation of excessive fluid in the neck.


Adult Acute Erythroid Leukemia

description: An acute erythroid leukemia occurring in adults.


name: Cervical Adenocarcinoma, Not Otherwise Specified

description: A cervical adenocarcinoma that cannot be classified by WHO criteria or International Endocervical Adenocarcinoma Criteria and Classification (IECC).


Phlebitis Infective, CTCAE

description: A disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein.


Pulmonary Function Test Reference Value

description: A standardized value that allows for the comparison of an individual's pulmonary function test results to those same results obtained from a reference population, which establishes a context through which individual results can be interpreted.


Grade 2 Uveitis, CTCAE

description: Anterior uveitis with 1+ or 2+ cells


Stage IS Testicular Cancer AJCC v8

description: Stage IS includes: Any pT/TX, N0, M0, S1-3. TX: Testicular cancer in which the primary tumor cannot be assessed. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. S3: LDH more than 10 x N or hCG (mlU/mL) more than 50,000 or AFP (ng/mL) more than 10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


name: Radiating Chest Pain Along Midclavicular Line

description: The location of the radiating chest pain is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.


name: Grade 2 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Senile Sebaceous Hyperplasia

description: A hyperplasia of the sebaceous glands. It is usually seen as small yellow papules in the face of middle aged-older population.


Grade 3 Hearing Impaired, CTCAE

description: Adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift of >25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated; Adults not enrolled on a Monitoring Program: Hearing loss with hearing aid or intervention indicated; limiting self care ADL; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Hearing loss sufficient to indicate therapeutic intervention, including hearing aids; threshold shift >20 dB at 2 to < 4 kHz in at least one ear


Malignant blue nevus of skin

description: A rare melanoma which develops in a pre-existing blue nevus. It occurs more frequently on the scalp, face, orbit, back, buttocks, extremities, hands, and feet.


name: Grade 3 Masculinization of Female, CTCAE


name: Gastric Neuroendocrine Tumor pM1b TNM Finding v8

description: Gastric neuroendocrine tumor with metastasis in at least one extrahepatic site (e.g., lung, ovary, nonregional lymph node, peritoneum, bone). (from AJCC 8th Ed.)


25-Hydroxyvitamin D Less than 30 ng/ml

description: A semiquantitative finding indicating that the concentration of 25-hydroxyvitamin D2 plus 25-hydroxyvitamin D3 is less than 30 ng/mL.


name: Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Localized Esophageal Carcinoma

description: Esophageal carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Appendix Traditional Serrated Adenoma

description: An adenoma that arises from the appendix.  It is characterized by prominent serration of the glands.


name: Rheumatoid Lung Disease with Rheumatoid Arthritis of Left Wrist

description: Evidence of rheumatoid lung disease with rheumatoid arthritis of left wrist.


Grade 2 Hepatic Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Colon or Rectum Neuroendocrine Tumor pNX TNM Finding v7

description: Colon or rectum neuroendocrine tumor in which regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


Sign

description: Objective evidence of disease perceptible to the examining healthcare provider.


name: Small Cell B-Cell Lymphoma, Intra-abdominal Lymph Nodes

description: Evidence of small cell B-cell lymphoma in the intra-abdominal lymph nodes.


Bile duct leakage

description: The leakage of bile into the abdominal cavity as a result of injury to the bile duct.


name: Carcinoma of the Conjunctiva pT2 TNM Finding v7

description: Carcinoma of the conjunctiva with tumor measuring more than 5 mm in greatest dimension without invasion of adjacent structures.  Adjacent structures include the cornea (3, 6, 9, or 12 clock hours), intraocular compartments, forniceal conjunctiva (lower and/or upper), palpebral conjunctiva (lower and/or upper), tarsal conjunctiva (lower and/or upper), lacrimal punctum and canaliculi (lower and/or upper), plica, caruncle, posterior eyelid lamella, anterior eyelid lamella, and/or eyelid margin (lower and/or upper).  (from AJCC 7th Ed.)


name: Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Delusional disorder, mixed type

description: A subtype of delusional disorder applied when no one delusional theme (such as grandiose, jealous, persecutory) predominates.


Irritation

description: A mild inflammatory tissue reaction; it can be caused by physical contact with an irritant or can be a local response to a systemic trigger.


name: Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Unanticipated Adverse Event

description: An adverse event that is unexpected, related or possibly related to an individual's participation in the research, and suggests that the research places subjects or others at greater risk of harm than was previously known or recognized.


name: Cerebral Infarction due to Thrombosis Unspecified Cerebellar Artery

description: Evidence of cerebral infarction due to a thrombosis of an unspecified cerebellar artery.


name: Chronic Post-Rheumatic Arthropathy, Unspecified Site

description: Evidence of chronic post-rheumatic arthropathy in an unspecified site.


name: Clinical Stage III Cutaneous Melanoma AJCC v8

description: Stage III includes: Any T, Tis, N1 or More, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N1: One tumor-involved node or in-transit, satellite, and/or microsatellite metastases with no tumor-involved nodes. N2: Two or three tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with one tumor-involved node. N3: Four or more tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with two or more tumor-involved nodes, or any number of matted nodes without or with in-transit, satellite, and/or microsatellite metastases. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Gastric Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 2 Other Renal or Genitourinary, CTCAE


name: Type 1 Diabetes Mellitus with Proliferative Diabetic Retinopathy with Traction Retinal Detachment Involving the Macula, Bilateral

description: Evidence of type 1 diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula that is bilateral.


Eyelid Carcinoma cM0 TNM Finding v8

description: Eyelid carcinoma with no evidence of distant metastasis. (from AJCC 8th Ed.)


Breast Cancer cM0 TNM Finding v6

description: Breast cancer in which there is no evidence of distant metastasis. (from AJCC 6th Ed.)


Pyrogenic Reaction

description: Fever reaction due to the presence of bacterial endotoxins.


Keratitis, CTCAE

description: A disorder characterized by inflammation to the cornea of the eye.


name: Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Neonatal Intraventricular Hemorrhage, AE

description: An adverse event in a newborn characterized by asymptomatic hemorrhage confined to the germinal matrix; minimal hemorrhage within the ventricle (less than 10% on parasagittal view).


name: Secondary parkinsonism due to other external agents

description: Evidence of secondary parkinsonism due to other external agents.


Recurrent Plasma Cell Leukemia

description: The reemergence of plasma cell leukemia after a period of remission.


name: Oral Complications of Cancer and Cancer Therapy


name: Ampulla of Vater Cancer pT2 TNM Finding v7

description: Ampulla of Vater cancer with tumor invading the duodenal wall. (from AJCC 7th Ed.)


Gliomatosis Cerebri Type I

description: A classic form of gliomatosis cerebri. It is characterized by diffuse growth of neoplastic glial tissue without any focal mass.


Grade 1 Mucosal Infection, CTCAE

description: Localized, local intervention indicated


Grade 4 Hematoma, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Prostate Cancer Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v8 classification system.


Cervical Cancer pT1 TNM Finding v9

description: Cervical carcinoma strictly confined to the cervix (extension to corpus should be disregarded). (from AJCC 9th Ed.)


name: Grade 2 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Pancreatic Neuroendocrine Tumor cM0 TNM Finding v8

description: Pancreatic neuroendocrine tumor without evidence of distant metastasis. (from AJCC 8th Ed.)


Grade 3 Laryngeal Inflammation, CTCAE

description: Severe throat pain; endoscopic intervention indicated


name: Subglottic Cancer pN1 TNM Finding v6 and v7

description: Subglottic cancer with metastasis to a single ipsilateral lymph node, 3 cm or less in greatest dimension. (from AJCC 6th and 7th Eds.)


name: Sedative, Hypnotic or Anxiolytic Abuse with Other Disorder

description: Evidence of sedative, hypnotic or anxiolytic abuse with other disorder.


Malignant Neoplasm of Right Lower Limb

description: Evidence of a malignant neoplasm of the right lower limb.


Refractory Glioma

description: Glioma that does not respond to treatment.


name: Mycosis Fungoides and Sezary Syndrome T3 TNM Finding v8

description: One or more tumors (equal or greater than 1 cm in diameter). Note: for skin, tumor indicates at least 1 cm diameter solid or nodular lesion with evidence of depth and/or vertical growth. Note the total number of lesions, total volume of lesions, largest size lesion, and region of body involved. Also note whether there is histologic evidence of large-cell transformation. Phenotyping for CD30 is encouraged. (from AJCC 8th Ed.)


name: Conjunctival Carcinoma pT4d TNM Finding v8

description: Conjunctival carcinoma with tumor invading brain. (from AJCC 8th Ed.)


cytotoxicity

description: The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.


name: Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acute Myeloid Leukemia with FUS-ERG

description: Acute myeloid leukemia associated with FUS-ERG gene fusion. The prognosis is poor.


name: Grade 1 Uterus Intra-Operative Injury, CTCAE


Cutaneous Melanoma pT4b TNM Finding v8

description: Cutaneous melanoma measuring more than 4.0 mm in thickness. Ulceration status: With ulceration. (from AJCC 8th Ed.)


name: Splenic marginal zone lymphoma stage III


Work-Related Smoke Exposure

description: Occupational exposure to airborne gases and particulates produced when materials undergo combustion or thermal decomposition.


Clotting of extracorporeal circuit

description: Thrombus formation within an apparatus that carries blood outside of the body, such as pheresis, dialysis or extracorporeal membrane oxygenation (ECMO).


Other Frontotemporal Dementia

description: Evidence of other frontotemporal dementia not specified elsewhere.


Grade 5 Cranial Nerve Infection, CTCAE

description: Death


name: Grade 4 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Esophagus and Esophagogastric Junction Cancer pT4b TNM Finding v8

description: Esophagus and esophagogastric junction cancer with tumor invading other adjacent structures, such as the aorta, vertebral body, or airway. (from AJCC 8th Ed.)


name: Follicular Lymphoma Grade IIIa, Extranodal and Solid Organ Sites

description: Evidence of follicular lymphoma grade IIIa in the extranodal and solid organ sites.


PSA Level Less than 0.01

description: An indication that a blood concentration of prostate specific antigen below 0.01 ng/mL was detected in a sample.


name: Diffuse Follicular Center Lymphoma, Intrapelvic Lymph Nodes

description: Evidence of diffuse follicular center lymphoma, intrapelvic lymph nodes.


name: Grade 2 Prostate Intra-Operative Injury, CTCAE


name: Regional Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has not spread to other regions.


Reiter's Disease, Unspecified Hand

description: Evidence of Reiter's disease in an unspecified hand.


name: Appendiceal Carcinoma pT4 TNM Finding v7

description: Appendiceal carcinoma with tumor penetrating visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invading other organs or structures.  Direct invasion in T4 includes invasion of other segments of the colorectum by way of the serosa, e.g., invasion of ileum.  Tumor that is adherent to other organs or structures grossly is classified cT4b.  However, if no tumor is present in the adhesion microscopically, the classification should be pT1-3 depending on the anatomical depth of wall invasion. (from AJCC 7th Ed.)


Vulvar Cancer cM0 TNM Finding v7

description: Vulvar cancer without evidence of distant metastasis. (from AJCC 7th Ed.)


Hormone Receptor Negative

description: A finding indicating that the tumor cells in a tissue sample are negative for hormone receptors.


name: Small Intestine Cancer pN2 TNM Finding v8

description: Small intestine cancer with metastasis in three or more regional lymph nodes. (from AJCC 8th Ed.)


Liver Cancer pT2 TNM Finding v7

description: Liver cancer with solitary tumor with vascular invasion or multiple tumors none more than 5 cm in greatest dimension. (from AJCC 7th Ed.)


TOP2A/CEP17 Copy Number Ratio Finding

description: A genetic copy number finding indicating the ratio of the number of signals for a probe targeting the TOP2A gene to the number of signals for a probe targeting the centromere of chromosome 17 (CEP17).


Chronic iridocyclitis

description: Uveitis that is usually insidious in onset, bilateral, and can be asymptomatic, most often affecting the anterior uveal tract, including the iris and ciliary body, and can result in long-term complications. It is most commonly associated with certain forms of juvenile idiopathic arthritis, but may occur independent of arthritis.


Castration-Sensitive Prostate Carcinoma

description: Metastatic prostatic carcinoma which is sensitive to androgen-deprivation therapy.


name: Stage I Adult Diffuse Mixed Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


T2 TNM Finding

description: A general term that refers to a TNM finding of primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to primary tumor that is more than 2.0 cm, but not more than 5.0 cm in greatest dimension; for cutaneous melanoma it refers to primary tumor that is 1.01 to 2 mm in thickness, with or without ulceration; for colorectal cancer it refers to primary tumor with invasion into the muscularis propria; and for bladder cancer it refers to primary tumor with invasion into the muscle layer.


Grade 2 Blurred Vision, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


Benign tumor of seminal vesicle

description: A neoplasm that arises from the seminal vesicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Gastrointestinal Anastomotic Leak, CTCAE

description: Death


Ectopic adrenal cortex

description: A term that refers to the presence of benign adrenal cortical tissue outside the adrenal glands.


Conjunctival Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the conjunctiva.


name: Grade 4 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Bladder Cancer pT4 TNM Finding v8

description: Bladder cancer with extravesical tumor directly invading any of the following: prostatic stroma, seminal vesicles, uterus, vagina, pelvic wall, abdominal wall. (from AJCC 8th Ed.)


Breast Cancer pN2a TNM Finding v8

description: Breast cancer with metastasis in 4-9 axillary lymph nodes (at least one tumor deposit larger than 2.0 mm). (from AJCC 8th Ed.)


name: Global Progressive Disease in Lymph Nodes

description: 50 percent or greater increase in the sum of products of diameter from baseline of lymph nodes; or any new node greater than 1.5 cm in the long axis or greater than 1cm in the short axis if 1-1.5 cm in the long axis that is proven to be N3 histologically; or loss of response with greater than 50 percent increase from nadir in sum of products of diameter of lymph nodes in those with partial response (whichever occurs first).


Vaginal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the vagina and another organ or anatomic site.


Increased Energy

description: Feeling of excessive energy, which may be associated with increased activity.


Pelvis Cancer pT2 TNM Finding v8

description: Pelvis cancer with tumor confined to one pelvic segment with extraosseous extension or two segments without extraosseous extension. (from AJCC 8th Ed.)


Carcinomatosis

description: Carcinoma that has spread diffusely to an anatomic site or throughout the body.


EGFR T790M Mutation Negative

description: Indicates that the T790M mutation of the epidermal growth factor receptor gene has not been detected in a sample.


Portal Vein Thrombosis, CTCAE

description: A disorder characterized by the formation of a thrombus (blood clot) in the portal vein.


Colorectal Cancer pM1 TNM Finding v8

description: Colorectal cancer with metastasis to one or more distant sites or organs or peritoneal metastasis is identified. (from AJCC 8th Ed.)


name: Cervical intraepithelial neoplasia grade 2

description: Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper half of the squamous epithelium and conspicuous nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal two thirds of the epithelium.


Grade 4 Aortic Valve Disease, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)


name: Malignant neoplasm overlapping accessory sinus site

description: Evidence of a malignant neoplasm of overlapping sites of accessory sinuses.


name: Grade 1 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


name: Other Specified Diabetes Mellitus with Foot Ulcer

description: Evidence of other specified diabetes mellitus with foot ulcer not specified elsewhere.


name: Merkel Cell Carcinoma cTX TNM Finding v8

description: Merkel cell carcinoma in which the primary tumor cannot be assessed (e.g., curetted). (from AJCC 8th Ed.)


Prostate cancer stage A

description: A clinically undetectable tumor confined to the prostate gland, normally an incidental finding during surgery.


name: Autoimmune Lymphoproliferative Syndrome-Related Lymphoma

description: A lymphoma that arises in the context of autoimmune lymphoproliferative syndrome.


Pleural Mesothelioma pN0 TNM Finding v7

description: Pleural mesothelioma with no regional lymph nodes metastases. (from AJCC 7th Ed.)


name: Carcinoma of the Eyelid cM1 TNM Finding v7

description: Carcinoma of the eyelid with distant metastasis. (from AJCC 7th Ed.)


name: Grade 5 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Merkel Cell Carcinoma cM1a TNM Finding v8

description: Merkel cell carcinoma with metastasis to distant skin, distant subcutaneous tissue, or distant lymph node(s). (from AJCC 8th Ed.)


Melanotic neurofibroma

description: A rare neurofibroma characterized by the presence of melanin-laden cells and the absence of atypia.


Apocrine Poroma

description: A poroma with apocrine differentiation.


name: Type 1 Diabetes Mellitus with Other Circulatory Complication

description: Evidence of type 1 diabetes mellitus with other circulatory complication.


name: Merkel Cell Carcinoma pNX TNM Finding v7

description: Merkel cell carcinoma in which the regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


name: Other Organ or System Involvement in Systemic Lupus Erythematosus

description: Evidence of other organ or system involvement in systemic lupus erythematosus not specified elsewhere.


Grade 2 Vulval Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 2, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 2 Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol.


Cutaneous Melanoma pN1 TNM Finding v8

description: Cutaneous melanoma with one tumor-involved node or in-transit satellite, and/or microsatellite metastases with no tumor-involved nodes. (from AJCC 8th Ed.)


Factory Smokestack Smoke Exposure

description: Environmental or occupational exposure to airborne gases and particulates emitted by a factory smokestack.


Solid carcinoma

description: A carcinoma morphologically characterized by the presence of solid sheets of malignant epithelial cells in tissues.


name: Mucosal Melanoma of the Head and Neck Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of mucosal melanoma of the head and neck, following the rules of the TNM AJCC v7 classification system.


Grade 3 Tracheal Mucositis, CTCAE

description: Severe pain; hemorrhage or respiratory symptoms; limiting self care ADL


Semiconsolidation Nodule

description: Nodule with dense (high) attenuation through which some normal underlying structures are visible. Semiconsolidation may appear as subsolid lung attenuation with thickened underlying reticulation or bronchovascular anatomy. In some instances, it may be challenging to distinguish the nodule from pGGNs or PSNs. The nodule is PSN if there is any solid component greater than 2 mm that is not underlying lung.


Grade 5 Laryngeal Edema, CTCAE

description: Death


name: Carcinoma of the Lacrimal Gland cM1 TNM Finding v7

description: Carcinoma of the lacrimal gland with distant metastasis. (from AJCC 7th Ed.)


name: Other Atherosclerosis of Other Type of Bypass Graft(s) of the Extremities, Unspecified Extremity

description: Evidence of other atherosclerosis of other type of bypass graft(s) of the extremities, unspecified extremity not specified elsewhere.


name: Grade 3 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Perihilar Bile Duct Cancer pN1 TNM Finding v8

description: Perihilar bile duct cancer with one to three positive lymph nodes typically involving the hilar, cystic duct, common bile duct, hepatic artery, posterior pancreatoduodenal, and portal vein lymph nodes. (from AJCC 8th Ed.)


Pancreatic Cystic Neoplasm

description: A benign, borderline, or malignant cystic neoplasm that arises from the exocrine pancreas. This category includes pancreatic mucinous-cystic neoplasms, pancreatic cystadenomas, and pancreatic cystadenocarcinomas.


name: Grade 1 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Pre-Existing Hypertensive Heart Disease Complicating Pregnancy, Second Trimester

description: Evidence of pre-existing hypertensive heart disease complicating pregnancy in the second trimester.


name: Grade 3 Other Musculoskeletal and Soft Tissue, CTCAE


Grade 4 Optic Nerve Disorder, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


Maturing Ganglioneuroma

description: A ganglioneuroma characterized by the presence of differentiating neuroblasts, maturing and mature ganglion cells.


Grade 1 Lymph Node Pain, CTCAE

description: Mild pain


Unresectable Paraganglioma

description: Paraganglioma that is not amenable to surgical resection.


name: Relapse from Complete Response of Multiple Myeloma or Plasma Cell Leukemia

description: Relapse from complete response of multiple myeloma or plasma cell leukemia requires one or more of the following: reappearance of serum or urine M-protein by immunofixation or electrophoresis; development of 5% or more plasma cells in the bone marrow (relapse from complete response has a 5% cutoff vs.10% for other categories of relapse); appearance of any other sign of progression (e.g., new plasmacytoma, lytic bone lesion, hypercalcemia). Relapse requires two consecutive assessments made at any time before classification as relapse, and/or the institution of any new therapy.


Thyroid Carcinoma TNM Finding v8

description: A finding about one or more characteristics of thyroid carcinoma, following the rules of the TNM AJCC v8 classification system.


Prostatic Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the prostate gland.


Testicular Cancer pNX TNM Finding v7

description: Testicular cancer in which regional lymph nodes cannot be assessed.  (from AJCC 7th Ed.)


name: Facial Weakness following Other Cerebrovascular Disease

description: Evidence of facial weakness following other cerebrovascular disease.


Stage III Osteosarcoma AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grid Artifact

description: Artifacts that result when the grid frequency is too low or when the grid orientation is parallel to the scan direction.


Grade 1 Fibrinogen Decreased, CTCAE

description: <1.0-0.75 x LLN; if abnormal, <25% decrease from baseline


Urethral Cancer pT4 TNM Finding v7

description: Urethral cancer with tumor invading other adjacent organs.  (from AJCC 7th Ed.)


Aphasia following Cerebral Infarction

description: Evidence of aphasia following cerebral infarction.


name: Grade 3 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


name: Other Malignant Neoplasm of Skin of Other Part of Trunk

description: Evidence of other malignant neoplasm of skin of other part of trunk not specified elsewhere.


Grade 3 Amnesia, CTCAE

description: Severe; long term memory loss; limiting self care ADL


name: Mechanical Complication of Biological Heart Valve Graft, Sequela

description: Evidence of mechanical complication of biological heart valve graft, sequela.


Excessive Sucking

description: A symptom of gastrointestinal dysfunction seen in neonates who have been exposed to drugs during pregnancy; often accompanied by excessive sucking of fists, fingers and thumbs.


Reiter's Disease, Left Knee

description: Evidence of Reiter's disease in the left knee.


Vulvar Cancer pN2 TNM Finding v7

description: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less, or two or more lymph node metastases measuring 5 mm or greater, or lymph node metastasis with extracapsular spread. (from AJCC 7th Ed.)


name: Arthropathy following Intestinal Bypass, Left Hand

description: Evidence of arthropathy following intestinal bypass in the left hand.


Fever Chills

description: Shivering secondary to a febrile process.


Supraglottic Cancer pT1 TNM Finding v8

description: Supraglottic cancer with tumor limited to one subsite of supraglottis with normal vocal cord mobility. (from AJCC 8th Ed.)


name: Grade 3 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Lymphoepithelial Cyst

description: A benign, unilocular or multilocular cyst that arises from the head and neck, usually the oral cavity, parotid gland, angle of mandible, and lateral neck. It is lined by epithelial cells and has a dense lymphoid stroma. It has been described in immunocompetent individuals and HIV-positive patients.


name: Grade 1 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Bone Cancer Pathologic Regional Lymph Nodes TNM Finding v7

description: A pathologic finding about one or more characteristics of bone cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.


name: Grade 2 Neck NOS Intra-Operative Injury, CTCAE


Abnormal Weight Loss

description: Unexplained or unintentional weight loss.


Vaginal Cancer pM1 TNM Finding v8

description: Vaginal cancer with distant metastasis. (from AJCC 8th Ed.)


name: Occlusion and Stenosis of Right Anterior Cerebral Artery

description: Evidence of occlusion and stenosis of right anterior cerebral artery.


alcoholic hepatitis with ascites

description: Evidence of alcoholic hepatitis with ascites.


Nodular Neoplasm

description: A benign or malignant neoplasm characterized by the formation of nodules by the proliferating neoplastic cells.


Grade 2 Psychosis, CTCAE

description: Moderate psychotic symptoms (e.g., disorganized speech; impaired reality testing)


name: Stage IV Adult Diffuse Mixed Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Grade 3 Hot Flashes, CTCAE

description: Severe symptoms; limiting self care ADL


Global Stable Disease

description: Failure to attain complete response, partial response, or progressive disease representative of all disease.  Partial response in skin and no nodes, blood and viscera category has a progressive disease and if any category involved at baseline, no complete or partial response in any.


Candidal endocarditis

description: Endocarditis caused by fungal infection with Candida species.


name: Nasal Cavity and Paranasal Sinuses Cancer Clinical TNM Finding v8

description: A clinical finding about one or more characteristics of nasal cavity and paranasal sinuses cancer, following the rules of the TNM AJCC v8 classification system.


Gastric Cancer pT1a TNM Finding v7

description: Gastric cancer with tumor invading lamina propria or muscularis mucosae.  (from AJCC 7th Ed.)


Urethral Cancer pN0 TNM Finding v8

description: Urethral cancer with no regional lymph node metastasis. (from AJCC 8th Ed.)


name: Distal Bile Duct Cancer pM1 TNM Finding v7

description: Distal bile duct cancer with distant metastasis. (from AJCC 7th Ed.)


name: Metastatic Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Acute Myeloid Leukemia, Myelodysplasia-Related

description: Acute myeloid leukemia, myelodysplasia-related that is resistant to treatment.


name: Non-Household Contact with SARS-CoV-2 Positive Individual

description: Exposure to an individual that does not live in the same residence but has tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Incomplete paraplegia

description: Evidence of incomplete paraplegia.


Sharp Chest Pain

description: The sensation of chest pain described as a stabbing feeling.


Pharyngeal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures).


name: Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Unspecified, Lymph Nodes of Axilla and Upper Limb

description: Evidence of an unspecified mature T-cell and NK-cell non-Hodgkin lymphoma in the lymph nodes of axilla and upper limb.


name: Bipolar Disorder, in Full Remission, Most Recent Episode Hypomanic

description: Evidence of bipolar disorder, in full remission, most recent episode hypomanic.


name: Type 1 Diabetes Mellitus with Other Diabetic Neurological Complication

description: Evidence of type 1 diabetes mellitus with other diabetic neurological complication.


Bilateral Thalamic Glioma

description: A glioma affecting both sides of the thalamus.


Eyelid Carcinoma pT3a TNM Finding v8

description: Eyelid carcinoma with tumor measuring more than 20 mm but 30 mm or less in greatest dimension without invasion of the tarsal plate or eyelid margin. (from AJCC 8th Ed.)


Grade 2 Nipple Deformity, CTCAE

description: Symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex


Solid Angioleiomyoma

description: A morphologic variant of angioleiomyoma characterized by the presence of numerous small, slit-like vascular channels.


PSA Level Greater than or Equal to One

description: A blood concentration of prostate specific antigen greater than or equal to 1 ng/mL.


Other Neurology, CTCAE

description: A finding indicating the presence of multiple pouches, usually in the colonic or gastric wall.


name: Childhood Pancreatic Acinar Cell Cystadenocarcinoma

description: An acinar cell cystadenocarcinoma that arises from the pancreas during childhood.


name: Cutaneous Squamous Cell Carcinoma of the Head and Neck pNX TNM Finding v8

description: Cutaneous squamous cell carcinoma of the head and neck in which the regional lymph nodes cannot be assessed.  (from AJCC 8th Ed.)


name: Diabetes Mellitus due to Underlying Condition with Mild Non-Proliferative Diabetic Retinopathy without Macular Edema, Bilateral

description: Evidence of diabetes mellitus due to underlying condition with mild non-proliferative diabetic retinopathy without macular edema that is bilateral.


Hypermutated Sample

description: A molecular finding indicating that the mutation rate is higher than 10 mutations per megabase (Mb) in a tissue sample.


name: Monoplegia of Lower Limb following Cerebral Infarction Affecting Right Non-Dominant Side

description: Evidence of monoplegia of lower limb following cerebral infarction affecting right non-dominant side.


name: Small Intestine Cancer Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of small intestine cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for small intestine cancer. (from AJCC 7th Ed.)


name: Hematologic Neoplasm with Germline Predisposition Associated with a Constitutional Platelet Disorder

description: Hematologic neoplasms associated with germline mutations and familial platelet disorders.


Conjunctivitis Infective, CTCAE

description: A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.


Primary Neoplasm

description: A tumor at the original site of origin.


Global Complete Response GvHD

description: A clinician overall severity score 0 following GvHD response.


name: Prostate Cancer Pathologic Primary Tumor TNM Finding v6

description: A pathologic finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


name: Peptic ulcer, chronic or unspecified with perforation

description: Evidence of chronic or unspecified peptic ulcer, site unspecified, with perforation.


name: Cocaine Dependence with Other Cocaine-Induced Disorder

description: Evidence of cocaine dependence with other cocaine-induced disorder.


name: Retinoblastoma Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of retinoblastoma, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Pathologic Stage IIB Cutaneous Melanoma AJCC v8

description: Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0). T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Hyperparathyroidism, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Adult Acute Promyelocytic Leukemia with PML-RARA

description: An acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA occurring in adults.


pM1c TNM Finding

description: A pathologic primary tumor TNM finding. The definition of PM1c finding depends on the particular type of cancer that it refers to; for example, for prostate cancer, PM1c TNM finding is defined as follows: cancer with metastasis to other site(s) with or without bone disease. (from AJCC 8th Ed.)


Carcinoma of urinary bladder, invasive

description: A carcinoma that arises from the bladder mucosa and invades the bladder wall.


Genetic Predisposition to Meningioma

description: An inherited condition caused by mutation(s) in the SMARCE1 gene, encoding SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1. The condition is characterized by an increased risk of developing meningioma.


Grade 1 Hypomagnesemia, CTCAE

description: <LLN-1.2 mg/dL; <LLN-0.5 mmol/L


name: Grade 4 Upper Extremity Vein Intra-Operative Injury, CTCAE


Grade 1 Hyperhidrosis, CTCAE

description: Limited to one site (palms, soles, or axillae); self care interventions


Infiltrating Cervical Carcinoma

description: A carcinoma that arises from the cervix and invades into the stromal tissue.


Hyperparathyroidism, CTCAE

description: A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).


Intraoperative injury

description: Trauma to the body occurring during a surgical intervention.


name: Invasive Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: An invasive urothelial carcinoma characterized by the presence of clear (glycogen-rich) cells.


Proximal Urethral Carcinoma

description: A carcinoma that arises from the proximal part of the urethra.


Carcinoma in situ of soft palate

description: Evidence of carcinoma in situ of the soft palate.


Foveolar hyperplasia

description: A hyperplasia of the gastric foveolar epithelium.


name: Diffuse Low Grade Glioma, FGFR1 Tyrosine Kinase Domain-Duplicated

description: Diffuse low-grade glioma characterized by internal tandem duplications of the sequences in the FGFR1 gene encoding the tyrosine kinase domain.


name: Grade 5 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Portal Hypertension, CTCAE

description: Reversal/retrograde portal vein flow; associated with varices and/or ascites


name: Endometrial Endometrioid Adenocarcinoma with Metaplastic Changes


name: Hepatocyte Nuclear Factor 1-Alpha Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene HNF1A, encoding the transcription factor hepatocyte nuclear factor 1-alpha. This condition may progress to diabetes later in life.


Injury of brachial plexus

description: Damage to the nerves in the brachial plexus network. These nerves originate in the spinal column and innervate the shoulder, arm and hand. Often, damage is sustained from overstretching or motor vehicle accidents.


name: Jejunum and Ileum Neuroendocrine Tumor pTX TNM Finding v8

description: Jejunum and ileum neuroendocrine tumor in which the primary tumor cannot be assessed. (from AJCC 8th Ed.)


name: Gestational Trophoblastic Neoplasm cM1a TNM Finding v8

description: Gestational trophoblastic neoplasm with lung metastasis. (from AJCC 8th Ed.)


name: Localized Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor confined to area of origin including abdominal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 3 Pelvis NOS Intra-Operative Injury, CTCAE


name: Grade 4 Fallopian Tube Obstruction, CTCAE


name: Grade 1 Gallbladder Intra-Operative Injury, CTCAE


name: Lennox-Gastaut syndrome, intractable, with status epilepticus

description: Evidence of Lennox-Gastaut syndrome, with status epilepticus that does not respond optimally to treatment.


name: Alanine Aminotransferase Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.


name: Grade 5 Female Genital Tract Fistula, CTCAE


Antepartum Obstetric Air Embolism

description: Presence of a large air bubble in the maternal vascular system which originated from a distant site during the antepartum period.


name: Grade 5 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ischemia Cerebrovascular, CTCAE

description: A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.


Paroxysmal Atrial Tachycardia, CTCAE

description: A disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria.


Immune-mediated adverse reaction

description: An adverse event resulting from an immune system reaction to a drug or device. It can affect any organ or system.


name: Grade 2 Laryngeal Nerve Dysfunction, CTCAE


Felty's Syndrome, Left Knee

description: Evidence of Felty's syndrome in the left knee.


FancD2 Nuclear Foci Absent

description: A laboratory test result indicating the absence of Fanconi anemia group D2 protein nuclear foci in cells.


Examination phobia

description: An overwhelming, irrational, and persistent fear of taking and failing tests.


Borderline Uterine Ligament Neoplasm

description: A rare borderline tumor that arises from the broad or other uterine ligaments. The majority of the reported cases are serous cystic tumors.


Progesterone Receptor Status

description: Indicates the progesterone receptor level measured in a primary tumor or in metastases. (>=10 is positive if measured in fmols/mg cytosol protein; Otherwise use institutional standards)


name: Other Specified Diabetes Mellitus with Moderate Nonproliferative Diabetic Retinopathy with Macular Edema, Right Eye

description: Evidence of other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema in the right eye not specified elsewhere.


name: Other Rheumatoid Arthritis with Rheumatoid Factor of Unspecified Shoulder

description: Evidence of other rheumatoid arthritis with rheumatoid factor of unspecified shoulder not specified elsewhere.


Adult L1 Acute Lymphoblastic Leukemia

description: L1 acute lymphoblastic leukemia that occurs during adulthood.


description: Evidence of toxic liver disease with chronic active hepatitis without ascites.


Mucolipidosis Type IIIA

description: A lysosomal storage disease characterized by multiple bone formation abnormalities, progressive joint stiffness, developmental abnormalities, hearing loss, hepatosplenomegaly, increased acne, enlarged tongue, and cornea clouding due to accumulation of lipid substances.