monobromobiphenyl

A bromobiphenyl carrying a single bromo substituent at unspecified position.


Grade 5 Hepatic Necrosis, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Death


name: Stage M1 Embryonal Tumor with Multilayered Rosettes

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Microscopic tumor cells are detected in the cerebrospinal fluid. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Lacrimal Gland Carcinoma pN1 TNM Finding v8

description: Lacrimal gland carcinoma with regional lymph node metastasis. (from AJCC 8th Ed.)


Lacrimal Gland Carcinoma TNM Finding v8

description: A finding about one or more characteristics of carcinomas of the lacrimal gland, following the rules of the TNM AJCC v8 classification system. There is no AJCC staging system for carcinomas of the nasolacrimal sac. Lymphomas are staged according to the classification for ocular adnexal lymphomas. No stage groupings are currently recommended for lacrimal gland carcinomas. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT4b TNM Finding v8

description: Lacrimal gland carcinoma with involvement of adjacent structures, including sinuses, temporal fossa, pterygoid fossa, superior orbital fissure, cavernous sinus, or brain and measuring more than 2 cm but 4 cm or less in greatest dimension. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma Pathologic Distant Metastasis TNM Finding v8

description: A pathologic finding about one or more characteristics of lacrimal gland carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Lacrimal Gland Carcinoma pNX TNM Finding v8

description: Lacrimal gland carcinoma in which the regional lymph nodes cannot be assessed. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT2 TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 2 cm but 4 cm or less in greatest dimension. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT0 TNM Finding v8

description: No evidence of primary tumor. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT3b TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 4 cm in greatest dimension with periosteal involvement only. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT4a TNM Finding v8

description: Lacrimal gland carcinoma with involvement of adjacent structures, including sinuses, temporal fossa, pterygoid fossa, superior orbital fissure, cavernous sinus, or brain and measuring 2 cm or less in greatest dimension. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma Pathologic TNM Finding v8

description: A pathologic finding about one or more characteristics of lacrimal gland carcinoma, following the rules of the TNM AJCC v8 classification system.


name: Lacrimal Gland Carcinoma pT2c TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 2 cm but 4 cm or less in greatest dimension with periosteal and bone involvement. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma cM0 TNM Finding v8

description: Lacrimal gland carcinoma with no distant metastasis. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma Clinical Distant Metastasis TNM Finding v8

description: A clinical finding about one or more characteristics of lacrimal gland carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.


name: Lacrimal Gland Carcinoma Pathologic Primary Tumor TNM Finding v8

description: A pathologic finding about one or more characteristics of lacrimal gland carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.


name: Lacrimal Gland Carcinoma pT2a TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 2 cm but 4 cm or less in greatest dimension with no periosteal or bone involvement. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT4c TNM Finding v8

description: Lacrimal gland carcinoma with involvement of adjacent structures, including sinuses, temporal fossa, pterygoid fossa, superior orbital fissure, cavernous sinus, or brain and measuring more than 4 cm in greatest dimension. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT2b TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 2 cm but 4 cm or less in greatest dimension with periosteal involvement only. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8

description: A pathologic finding about one or more characteristics of lacrimal gland carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.


name: Lacrimal Gland Carcinoma pT3 TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 4 cm in greatest dimension. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pTX TNM Finding v8

description: Primary tumor cannot be assessed. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pM1 TNM Finding v8

description: Lacrimal gland carcinoma with distant metastasis. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma cM1 TNM Finding v8


name: Lacrimal Gland Carcinoma pT4 TNM Finding v8

description: Lacrimal gland carcinoma with involvement of adjacent structures, including sinuses, temporal fossa, pterygoid fossa, superior orbital fissure, cavernous sinus, or brain. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma Clinical TNM Finding v8

description: A clinical finding about one or more characteristics of lacrimal gland carcinoma, following the rules of the TNM AJCC v8 classification system.


name: Lacrimal Gland Carcinoma pT3c TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 4 cm in greatest dimension with periosteal and bone involvement. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pT3a TNM Finding v8

description: Lacrimal gland carcinoma with tumor measuring more than 4 cm in greatest dimension with no periosteal or bone involvement. (from AJCC 8th Ed.)


name: Lacrimal Gland Carcinoma pN0 TNM Finding v8

description: Lacrimal gland carcinoma with no regional lymph node metastasis. (from AJCC 8th Ed.)


name: Prostate Acinar Adenocarcinoma, Atrophic Pattern

description: An unusual variant of acinar prostate adenocarcinoma characterized by the presence of neoplastic small atrophic glands that contain malignant cells with scant cytoplasm.


name: Gestational Trophoblastic Tumor pM1a TNM Finding v7

description: Gestational trophoblastic tumor with lung metastasis. (from AJCC 7th Ed.)


name: Gestational Trophoblastic Tumor TNM Finding v7

description: A finding about one or more characteristics of gestational trophoblastic tumor, following the rules of the TNM AJCC v7 classification system.


name: Gestational Trophoblastic Tumor pM1b TNM Finding v7

description: Gestational trophoblastic tumor with all other distant metastasis. (from AJCC 7th Ed.)


name: Gestational Trophoblastic Tumor Pathologic Distant Metastasis TNM Finding v7

description: A pathologic finding about one or more characteristics of gestational trophoblastic tumor, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.  There is no pathologic M0 for gestational trophoblastic tumor.


name: Gestational Trophoblastic Tumor Pathologic Primary Tumor TNM Finding v7

description: A pathologic finding about one or more characteristics of gestational trophoblastic tumor, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor.


name: Gestational Trophoblastic Tumor Pathologic TNM Finding v7

description: A pathologic finding about one or more characteristics of gestational trophoblastic tumor, following the rules of the TNM AJCC v7 classification system.


name: Gestational Trophoblastic Tumor pM1 TNM Finding v7

description: Gestational trophoblastic tumor with distant metastasis. (from AJCC 7th Ed.)


name: Gestational Trophoblastic Tumor pTX TNM Finding v7

description: Gestational trophoblastic tumor in which the primary tumor cannot be assessed. (from AJCC 7th Ed.)


name: Gestational Trophoblastic Tumor pT1 TNM Finding v7

description: Gestational trophoblastic tumor confined to uterus. (from AJCC 7th Ed.)


name: Gestational Trophoblastic Tumor pT0 TNM Finding v7

description: Gestational trophoblastic tumor with no evidence of primary tumor. (from AJCC 7th Ed.)


name: Gestational Trophoblastic Tumor pT2 TNM Finding v7

description: Gestational trophoblastic tumor extending to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension. (from AJCC 7th Ed.)


N-acylserine 18:1

An N-acylserine in which the acyl group contains 18 carbons and 1 double bond.


phosphatidylglycerol 37:0

A phosphatidylglycerol in which the two acyl groups contain 37 carbon atoms and no double bonds


N-(1,2-saturated acyl)sphinganine

Any dihydroceramide having a methylene group adjacent to the ceramide carbonyl group.


name: Rheumatoid Arthritis without Rheumatoid Factor, Right Wrist

description: Evidence of rheumatoid arthritis without rheumatoid factor in the right wrist.


name: multiple system atrophy 1, susceptibility to


Wound Complication

description: A medical condition that develops at the site of an existing wound. Examples include swelling, draining, bleeding, formation of hematoma, infection, and necrosis.


Impaired Healing

description: Improper body tissue repair due to factors affecting one or more of the phases of wound healing, including hemostasis, inflammation, proliferation, and remodeling.


Grade 1 Telangiectasia, CTCAE

description: Telangiectasias covering <10% BSA


name: multiple epiphyseal dysplasia, with severe proximal femoral dysplasia

description: Multiple epiphyseal dysplasia, with severe proximal femoral dysplasia is a rare primary bone dysplasia characterized by severe, early-onset dysplasia of the proximal femurs, with almost complete absence of the secondary ossification centers and abnormal development of the femoral necks (short and broad with irregular metaphyses). It is associated with gait abnormality, mild short stature, arthralgia, joint stiffness with limited mobility of the hips and irregular acetabula, and hip and knee pain. Coxa vara and mild spinal changes are also associated.


Prostate cancer stage C

description: Tumor is clinically localized to the periprostatic area, but extends through the prostatic capsule; the seminal vesicles may be involved.


(S)-metamifop

A 2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide that has S-configuration.


A member of the class of 1,3-benzoxazoles that is 6-chloro-1,3-benzoxazol-2-ol in which the hydrogen of the hydroxy group at position 2 is substituted by a 4-({1-[(2-fluorophenyl)(methyl)amino]-1-oxopropan-2-yl}oxy)phenyl group.


metamifop

A 2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N-(2-fluorophenyl)-N-methylpropanamide that has R-configuration. It is an inhibitor of acetyl-coenzyme A carboxylase (ACCase) and a postemergence herbicide which exhibits high control efficacy against sensitive weeds, especially Echinochloa crus-galli in paddy fields.


N,O-dioleoylethanolamine

A fatty acid ester obtained by formal condensation of the carboxy group of oleic acid with the hydroxy group of oleoyl ethanolamide.


N,O-diacylethanolamine

Any carboxamide obtained by acylation of both the amino and hydroxy functions of ethanolamine.


name: non-severe combined immunodeficiency due to polymerase delta deficiency

description: Any non-severe combined immunodeficiency in which the cause of the disease is variation in the POLD1/POLD2 gene.


L-alanyl-L-glutamic acid

A dipeptide consisting of L-glutamic acid having an L-alanyl attached to its alpha-amino group


sideretin acetylhexoside

R1=acetylhexoside,R2=H,R3=H; R1=H,R2=acetylhexoside,R3=H; R1=H,R2=H,R3=acetylhexoside


ear neoplasm

description: A neoplasm (disease) that involves the ear.


perichondritis of auricle

description: An otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.


name: congenital corneal opacities, cornea guttata, and corectopia


tympanic membrane disorder

description: A disease involving the tympanic membrane.


chronic eustachian salpingitis

description: Chronic form of otosalpingitis.


acute perichondritis of pinna

description: Acute form of perichondritis of auricle.


acute infection of pinna

description: An otitis externa which involves bacterial infections often related to underlying comorbidities as well as trauma. Common sources of trauma include ear piercing, boxing, blunt trauma, burns, bite wounds and iatrogenic insults. The common bacterial pathogens are staphylococcal and streptococcal species.


benign neoplasm of middle ear

description: A benign neoplasm that involves the middle ear.


autoimmune inner ear disease

description: A syndrome characterized by rapidly progressive sensorineural hearing loss (SNHL), that is often bilateral, and is potentially reversible.


space motion sickness

description: Disorder characterized by nausea, vomiting, and dizziness, possibly in response to vestibular disorientation or fluid shifts associated with space flight. (From Webster's New World Dictionary)


external ear disorder

description: A disease involving the external ear.


external ear neoplasm

description: A neoplasm (disease) that involves the external ear.


cholesteatoma of external ear

description: A cholesteatoma (disease) that involves the external ear.


polyp of middle ear

description: A benign polypoid growth in the middle ear.


acute eustachian salpingitis

description: Acute form of otosalpingitis.


chronic fungal otitis externa

description: Chronic form of otomycosis.


tympanitis

description: An inflammatory disease involving a pathogenic inflammatory response in the tympanic membrane.


external ear lipoma

description: A benign adipose tissue neoplasm of the external ear.


name: chronic tubotympanic suppurative otitis media

description: A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections.


chronic tympanitis

description: Chronic form of tympanitis.


middle ear disorder

description: A disease involving the middle ear.


acute allergic mucoid otitis media

description: A blue drum syndrome caused by an allergen.


benign neoplasm of ear

description: A benign neoplasm that involves the ear.


myringitis bullosa hemorrhagica

description: A tympanic membrane disease that is characterized by blisters on the eardrum resulting from infection.


name: active cochleovestibular Meniere disease


infectious otitis media

description: Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space.


acute sanguinous otitis media

description: A acute transudative otitis media which involves bloody effusion.


middle ear cancer

description: A malignant neoplasm involving the middle ear


middle ear neuroendocrine tumor

description: A neuroendocrine neoplasm that involves the middle ear.


noxacusis

description: Noxacusis/pain hyperacusis is characterized by individuals who experience otalgia or pain (e.g., dull ache, burning, sharp, stabbing pain and throbbing pain) in response to everyday sounds. This differs clinically from those whose primary symptom is the perception of everyday sounds as excessively loud (termed loudness hyperacusis).


inner ear cancer

description: A malignant neoplasm involving the internal ear.


benign paroxysmal positional vertigo

description: Idiopathic recurrent vertigo associated with positional nystagmus. It is associated with a vestibular loss without other neurological or auditory signs. Unlike in labyrinthitis and vestibular neuronitis inflammation in the ear is not observed.


suppurative otitis media

description: Inflammation of the middle ear with purulent discharge.


chronic perichondritis of pinna

description: Chronic form of perichondritis of auricle.


chronic non-suppurative otitis media

description: Chronic form of non-suppurative otitis media.


eustachian tube disorder

description: A disease involving the pharyngotympanic tube.


internal auditory canal lipoma

description: A rare benign adipose tissue neoplasm of the internal auditory canal, often presenting as an acoustic tumor. It may be intermixed with the vestibulocochlear nerve and may adhere to adjacent structures.


non-suppurative otitis media

description: A otitis media which involves transudation of fluid in the middle ear without pus formation.


internal auditory canal meningioma

description: A meningioma that affects the internal auditory canal.


patulous eustachian tube

description: A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection.


acute serous otitis media

description: A acute transudative otitis media with thin, watery and sterile effusion.


chronic purulent otitis media

description: Otitis media that persists for at least six weeks, and that is associated with otorrhea through a perforated tympanic membrane.


acute transudative otitis media

description: Acute form of non-suppurative otitis media.


polyp of external auditory canal

description: A polyp that involves the external acoustic meatus.


acute allergic sanguinous otitis media

description: A acute sanguinous otitis media caused by an allergen.


external ear cancer

description: A malignant neoplasm involving the external ear.


serous glue ear

description: Chronic form of serous otitis media.


otosalpingitis

description: An inflammatory disease involving a pathogenic inflammatory response in the pharyngotympanic tube.


name: X-linked mixed hearing loss with perilymphatic gusher

description: X-linked mixed deafness with perilymphatic gusher, also known as X-linked deafness type 2, is a rare form of non-syndromic genetic deafnesss affecting males and characterized by pathognomonic inner ear anomalies and conductive and profound sensorineural hearing loss. The inner ear anomalies are described as dilatation of the internal auditory meatus and fistulous connection between the cochlear basal turn and internal auditory canal resulting in perilympatic gusher on attempted mobilization of a fixed stapes. Obligate female carriers may suffer from mild to moderate hearing loss.


cholesteatoma of attic

description: A cholesteatoma in the attic


cholesteatoma of middle ear

description: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.


purulent acute otitis media

description: Acute form of suppurative otitis media.


acute otitis externa

description: Acute form of otitis externa.


blue drum syndrome

description: A acute transudative otitis media involving thick, viscid and mucuslike fluid effusion due to which the drum appears blue in color.


malignant otitis externa

description: An otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.


allergic otitis media

description: A otitis media (disease) with a basis in a pathological type I hypersensitivity reaction.


acute allergic serous otitis media

description: A acute serous otitis media caused by an allergen.


chronic atticoantral disease

description: A chronic purulent otitis media which involves perforation in the attic region (pars flaccida of the tympanic membrane) or at the posterosuperior margin, with in-growth of squamous epithelium into the middle ear. This is caused as a result of poor ventilation of the middle ear and episodes of infection.


name: malignant otitis externa caused by Pseudomonas aeruginosa

description: An malignant otitis externa caused by infection with Pseudomonas aeruginosa.


phacogenic glaucoma

description: Secondary glaucoma caused by either excessive size or spheric shape of the lens.


phacolytic glaucoma

description: An abnormal condition characterized by an acute autoimmune reaction of the eye. It is caused by hypersensitivity of the eye to the protein of the crystalline lens and commonly follows trauma to the crystalline lens or cataract surgery. Associated symptoms include swelling and inflammation of the eye, severe pain, and blurred vision. The substance of the lens is invaded by polymorphonuclear cells and mononuclear phagocytes. Accurate diagnosis must differentiate between this condition and infectious endophthalmitis. Therapy is supportive and commonly includes the administration of corticosteroids and atropine. Refractory cases may require surgical removal of the lens.


Grade 5 Vaginal Stricture, CTCAE

description: Death


Vaginal Stricture, CTCAE

description: A disorder characterized by a narrowing of the vaginal canal.


Grade 2 Vaginal Stricture, CTCAE

description: Vaginal narrowing and/or shortening not interfering with physical examination


Grade 1 Vaginal Stricture, CTCAE

description: Asymptomatic; mild vaginal shortening or narrowing


Grade 3 Vaginal Stricture, CTCAE

description: Vaginal narrowing and/or shortening interfering with the use of tampons, sexual activity or physical examination


The 5alpha-stereoisomer of cholestane.


EPIDIHYDROCHOLESTERIN

A 5alpha-chloestane compound having a 3alpha-hydroxy substituent.


Colorectal Traditional Serrated Adenoma

description: An adenoma that arises from the colon or rectum.  It is characterized by prominent serration of the glands.


Colon Traditional Serrated Adenoma

description: An adenoma that arises from the colon.  It is characterized by prominent serration of the glands.


Colorectal Filiform Serrated Adenoma

description: A traditional serrated adenoma that arises from the colon or rectum.  It is characterized by the presence of prominent villous projections of the neoplastic epithelium.


SEC61A1 deficiency

description: Any Mendelian disease in which the cause of the disease is a mutation in the SEC61A1 gene. It is characterized by variable presentation of phenotypes in patients, including autosomal dominant tubulointerstitial kidney disease, primary antibody deficiency, and severe congenital neutropenia.


name: hyperuricemic nephropathy, familial juvenile type 4

description: Any familial juvenile hyperuricemic nephropathy in which the cause of the disease is a mutation in the SEC61A1 gene.


A ceramide that is the N-tetracosanoyl derivative of 4-hydroxyeicosasphinganine.


name: Perfusion Computed Tomography Target Lesion

description: A target lesion that has been identified by computed tomography perfusion imaging.


An acetamide compound of general formula RCH2CH2NHC(=O)CH3 where R represents an aryl moiety.


A trivalent inorganic anion obtained by removal of three protons from orthoperiodic acid


iodite

A monovalent inorganic anion obtained by deprotonation of iodous acid.


chlorate salt

Any salt that has chlorate, [ClO3](-), as the anionic component.


bromite

A monovalent inorganic anion obtained by deprotonation of bromous acid.


A monovalent inorganic anion obtained by deprotonation of one of the six OH groups in orthoperiodic acid  acid.


hypoiodite

A monovalent inorganic anion obtained by deprotonation of hypoiodous acid.


A divalent inorganic anion obtained by removal of two of the five protons from orthoperiodic acid


periodate

A monovalent inorganic anion obtained by deprotonation of periodic acid.


perbromate

A monovalent inorganic anion obtained by deprotonation of perbromic acid.


hypofluorite

A monovalent inorganic anion obtained by deprotonation of hypofluorous acid.


A monovalent inorganic anion obtained by deprotonation of fluorous acid.


hypobromite

A monovalent inorganic anion obtained by deprotonation of hypobromous acid.


myofibrillar myopathy 3

description: A rare, late adult-onset myofibrillar myopathy characterized by progressive distal muscle weakness associated with peripheral neuropathy and hyporeflexia. Ambulation may be lost within a few years.


methyl 3,5-di-O-caffeoyl quinate

A methyl ester resulting from the formal condensation of the carboxy group of 3,5-di-O-caffeoyl quinic acid with methanol. Isolated from Suaeda glauca and Dichrocephala bicolor, it exhibits hepatoprotective activity.


Penile Glomus Tumor

description: A glomus tumor that occurs in the penis.


Bone Glomus Tumor

description: A benign or malignant glomus tumor arising from the bone.


name: Glomus tumor of uncertain malignant potential

description: A glomus tumor that shows atypical characteristics and has borderline malignant potential.


Solid Glomus Tumor

description: The most common morphologic variant of glomus tumor.  It is characterized by the presence of a nest of glomus cells surrounding capillary sized vessels.


Benign Glomus Tumor

description: A glomus tumor of small size characterized by the absence of nuclear atypia and mitotic activity.


Gastric Glomus Tumor

description: A rare glomus tumor that arises from the stomach.  It is seen in adults, especially women.  The majority of cases follow a benign clinical course.


RHAMNOCITRIN

A monomethoxyflavone that is the 7-methyl ether derivative of  kaempferol.


peroxisome biogenesis disorder type 3B

description: A genetic disorder characterized by abnormalities in the breakdown of phytanic acid. It results in accumulation of phytanic acid in the blood, brain and other tissues. Signs and symptoms include retinitis pigmentosa which may lead to blindness, hearing problems and deafness, hypotonia, ataxia, nystagmus, facial deformities, and mental and growth retardation.


Grade 1 Dysmenorrhea, CTCAE

description: Mild symptoms; intervention not indicated


name: Other Specified Rheumatoid Arthritis, Right Knee

description: Evidence of other specified rheumatoid arthritis in the right knee not specified elsewhere.


DPYD Negative

description: An indication that expression of DPYD has not been detected in a sample.


Stage IVA Ovarian Cancer AJCC v8

description: Stage IVA includes: Any T, Any N, M1a. M1a: Ovarian cancer with pleural effusion with positive cytology. (from AJCC 8th Ed.)


Stage IV Ovarian Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine. (from AJCC 8th Ed.)


Stage IVB Ovarian Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1b. M1b: Ovarian cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine. (from AJCC 8th Ed.)


Anal Cancer pT4 TNM Finding v8

description: Anal cancer with tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. (from AJCC 8th Ed.)


smallpox

description: A condition that is caused by infection with Variola, and that is characterized by small, raised bumps.


Modified smallpox

description: Smallpox that occurs in an individual who has been vaccinated.


name: Testicular Germ Cell Neoplasia In Situ with Extratubular Extension

description: A malignant neoplasm that arises from the testis and is characterized by the presence of large germ cells with abundant cytoplasm in the seminiferous tubules, associated with an invasive germ cell tumor in the adjacent tissues.


Grade 1 Stoma Site Infection, CTCAE

description: Localized, local intervention indicated


trisomy 9p

description: Trisomy 9p is a rare chromosomal anomaly syndrome, resulting from a partial or complete trisomy of the short arm of chromosome 9, with a wide phenotypic variablility, typically characterized by intellectual disability, craniofacial dysmorphism (e.g. microcephaly, large anterior fontanel, hypertelorism, strabismus, downslanting palpebral fissures, malformed, low-set, protruding ears, bulbous nose, macrostomia, down-turned corners of mouth, micrognathia), digital anomalies (brachydactyly and clinodactyly), and short stature. Less frequently patients present with cardiopathy and renal, skeletal, and central nervous system malformations.


A very long-chain omega-6 fatty acid that is triacontanoic acid having four double bonds located at positions 15, 18, 21 and 24 (the 15Z,18Z,21Z,24Z-isomer).


N-acetyl-D-hexosamine

Any N-acetylhexosamine in which the hexosamine has D-configuration. The structure provided is an illustrative example of the pyranose form of an N-acetyl-D-hexosamine.


N-acetyl-D-galactosamine

The D-enantiomer of N-acetylgalactosamine.


N-acetyl-alpha-D-glucosamine

An N-acetyl-D-glucosamine that has alpha-configuration at the anomeric centre.


hercynyl-SeGlcNAc selenoxide

Major species at pH 7.3


N-Acetylglucosamine

An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.


N-acetyl-beta-D-mannosamine

An N-acetyl-D-mannosamine having beta-configuration at its anomeric centre.


N-ACETYLMANNOSAMINE

An N-acetylmannosamine having pyranose form and alpha-D-configuration.


N-acetyl-alpha-D-galactosamine

An N-acetyl-D-galactosamine having alpha-configuration at the anomeric centre.


N-acetyl-beta-D-galactosamine

An N-acetyl-D-galactosamine having beta-configuration at the anomeric centre.


N-acetyl-D-mannosamine

An N-acetylmannosamine having D-configuration.


Adrenal Cancer pT2 TNM Finding v7

description: Adrenal cancer with tumor measuring more than 5 cm in greatest dimension without extra-adrenal invasion. (from AJCC 7th Ed.)


Spine Cancer pT4b TNM Finding v8

description: Spine cancer with evidence of gross vascular invasion or tumor thrombus in the great vessels. (from AJCC 8th Ed.)


Spine Cancer pT4 TNM Finding v8

description: Spine cancer with tumor extending into the spinal canal or great vessels. (from AJCC 8th Ed.)


Spine Cancer pT4a TNM Finding v8

description: Spine cancer with tumor extending into the spinal canal. (from AJCC 8th Ed.)


name: Pauciarticular Juvenile Rheumatoid Arthritis, Other Specified Site

description: Evidence of pauciarticular juvenile rheumatoid arthritis in the other specified site.


name: Cutaneous Melanoma Pathologic TNM Finding v6

description: A pathologic finding about one or more characteristics of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system. TNM pathologic findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


Cutaneous Melanoma pN2 TNM Finding v6

description: Cutaneous melanoma involving two to three regional lymph nodes, or involving the regional intra-lymphatic system without nodal involvement. (from AJCC 6th Ed.)


Cutaneous Melanoma pM1 TNM Finding v6

description: Cutaneous melanoma with distant metastasis. (from AJCC 6th Ed.)


name: Cutaneous Melanoma pN0 TNM Finding v6 and v7

description: Cutaneous melanoma without involvement of regional lymph nodes. (from AJCC 6th and 7th Eds.)


Cutaneous Melanoma pM1b TNM Finding v6

description: Cutaneous melanoma with metastasis to lung. (from AJCC 6th Ed.)


Cutaneous Melanoma pN2a TNM Finding v6

description: Cutaneous melanoma with microscopic, clinically occult metastasis to two or three regional lymph nodes. (from AJCC 6th Ed.)


name: Cutaneous Melanoma Pathologic Distant Metastasis TNM Finding v6

description: A pathologic finding about one or more characteristics of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


name: Cutaneous Melanoma pN3 TNM Finding v6 and v7

description: Cutaneous melanoma involving four or more regional lymph nodes, or with a finding of matted metastatic nodes, or with in-transit metastasis or satellite(s) with metastasis in regional lymph node(s). (from AJCC 6th and 7th Eds.)


Cutaneous Melanoma pM1a TNM Finding v6

description: Cutaneous melanoma with metastasis to skin, subcutaneous tissues or distant lymph nodes. (from AJCC 6th Ed.)


Cutaneous Melanoma pM0 TNM Finding

description: Cutaneous melanoma with no evidence of distant metastasis. (from AJCC 6th Ed.)


Cutaneous Melanoma pNX TNM Finding v6

description: Cutaneous melanoma in which the regional lymph nodes cannot be assessed. (from AJCC 6th Ed.)


Cutaneous Melanoma pM1c TNM Finding

description: Cutaneous melanoma with metastases to all other visceral sites associated with normal serum lactate dehydrogenase (LDH) or distant metastases to any site associated with an elevated serum LDH. (from AJCC 6th and 7th Eds.)


name: Cutaneous Melanoma Pathologic Regional Lymph Nodes TNM Finding v6

description: A pathologic finding about one or more characteristics of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system as they pertain to staging of regional lymph nodes. TNM pathologic regional lymph nodes findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


Cutaneous Melanoma pN1 TNM Finding v6

description: Cutaneous melanoma with involvement of one lymph node. (from AJCC 6th Ed.)


Cutaneous Melanoma pN1b TNM Finding v6

description: Cutaneous melanoma with macroscopic, clinically apparent metastasis to a single lymph node. (from AJCC 6th Ed.)


Cutaneous Melanoma pMX TNM Finding

description: Cutaneous melanoma in which the status of distant metastasis cannot be assessed. (from AJCC 6th Ed.)


Cutaneous Melanoma pN1a TNM Finding v6

description: Cutaneous melanoma with microscopic, clinically occult metastasis to a single lymph node. (from AJCC 6th Ed.)


Cutaneous Melanoma pN2c TNM Finding v6

description: Cutaneous melanoma without involvement of regional lymph nodes, with satellite or in-transit metastasis. (from AJCC 6th Ed.)


Cutaneous Melanoma pN2b TNM Finding v6

description: Cutaneous melanoma with macroscopic, clinically apparent metastasis to two or three regional lymph nodes. (from AJCC 6th Ed.)


Head and Neck Rhabdomyosarcoma

description: A malignant neoplasm with skeletal muscle differentiation that arises from the head and neck. It usually affects the orbit, eyelid, ear, sinonasal tract, and nasopharynx.


orbit alveolar rhabdomyosarcoma

description: A malignant mesenchymal neoplasm that arises in the orbit. It is characterized by the presence of round cells with myoblastic differentiation and a fibrovascular stroma.


Sinonasal Rhabdomyosarcoma

description: A rhabdomyosarcoma that arises from the nasal cavity and paranasal sinuses.


orbit rhabdomyosarcoma

description: A malignant mesenchymal neoplasm with skeletal muscle differentiation that arises from the orbit.


Advanced Rectal Squamous Cell Carcinoma

description: Rectal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Rectal Squamous Cell Carcinoma

description: Rectal squamous cell carcinoma that has spread from the original site of growth to other anatomic sites.


name: Locally Advanced Rectal Squamous Cell Carcinoma

description: Rectal squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


Hormonal Change

description: A finding indicating a deficiency or excess of one or more hormones.


Metanephrine-Secreting

description: A finding indicating that an excess amount of metanephrine is secreted by a tumor.


Prothyroliberin Release

description: Any process in which the tripeptide hormone prothyroliberin is released from the hypothalamus, processed and bound to receptors in the anterior pituitary, resulting in sustained release of prolactin from the anterior pituitary. Thyroliberin may be elevated in primary hypothyroidism, resulting in elevated prolactin secretion. This process is involved in regulating the levels of both prolactin and thyroid-stimulating hormone.


Normetanephrine-Secreting

description: A finding indicating that an excess amount of normetanephrine is secreted by a tumor.


Placental Hormone Activity Alteration

description: Any physiologic process that results in modulated activity of any of the placental hormones, including choriogonadotropic hormone, chorionic somatomammotropin hormone, inhibin, estrogen and progesterone. These processes are involved in physiologic changes that support pregnancy.


Thyroid Hormone Iodination Alteration

description: A finding indicating a deficiency or excess in iodination of thyroid hormone.


Estrogen Metabolism Alteration

description: Any physiologic process that results in modulated metabolism of estrone, estradiol and estriol in both females and males. Such a process may be observed during pregnancy, or in the context of chemotherapeutic intervention, particulary with the use of aromatase inhibitors.


Prolactin Inhibiting Factor Release

description: Any process in which the monoamine neurohormone dopamine is released from the arcuate nucleus of the hypothalamus and binds to receptors in the anterior pituitary, resulting in inhibition of secretion of prolactin. This process is involved in terminating the production of milk once lactation is complete.


Methoxytyramine-Secreting

description: A finding indicating that an excess amount of methoxytyramine is secreted by a tumor.


Gonadotropin Secretion Abnormality

description: An abnormality of gonadotropin production resulting in abnormal levels of circulating gonadotropin.


Norepinephrine-Secreting

description: A finding indicating that an excess amount of norepinephrine is secreted by a tumor.


Dopamine-Secreting

description: A finding indicating that an excess amount of dopamine is secreted by a tumor.


Renal Hormone Activity Alteration

description: Any physiologic process that results in modulated activity of any of the renal hormones, including renin, erythropoietin, thrombopoietin and calcitriol. These processes are involved in regulation of blood pressure, production of red blood cells and platelets, and calcium homeostasis.


Epinephrine-Secreting

description: A finding indicating that an excess amount of epinephrine is secreted by a tumor.


Growth Hormone Secretion Abnormality

description: An abnormal production of growth hormone.


Somatotropin deficiency

description: Abnormally low levels of circulating somatotropin.


(R)-tetrahydropapaverine

The R-enantiomer of tetrahydropapaverine.


(R)-goitrin

A 5-ethenyl-1,3-oxazolidine-2-thione that has R-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis.


An omega-hydroxy fatty acid ascaroside that is oscr#30 in which the pro-R hydrogen beta to the carboxy group is replaced by a hydroxy group. It is a metabolite of the nematode Caenorhabditis elegans.


name: Grade 3 Sinusoidal Obstruction Syndrome, CTCAE

description: Blood bilirubin >5 mg/dL; coagulation modifier indicated (e.g., defibrotide); reversal of flow on ultrasound


A methyl glycoside that is beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranose in which the anomeric hydroxy group is replaced by methoxy.


name: Grade 1 Neonatal Pulmonary Hemorrhage, AE

description: An adverse event in a newborn characterized by limited hemorrhagic secretion in an endotracheal (ET) tube.


name: Atherosclerosis of Native Arteries of Left Leg with Ulceration of Heel and Midfoot

description: Evidence of atherosclerosis of native arteries of left leg with ulceration of heel and midfoot.


tetradecanoyl-AMP

A fatty acyl-AMP that results from the formal condensation of the phosphoryl group of AMP with the carboxyl group of tetradecanoic (myristic) acid.


name: Other Specified Malignant Neoplasm of Skin of Breast

description: Evidence of other specified malignant neoplasm of skin of breast not specified elsewhere.


Circulating Lymphocyte Response

description: An assessment of the disease response to therapy based on circulating lymphocyte count.


Grade 3 Erythema Multiforme, CTCAE

description: Target lesions covering >30% BSA and associated with oral or genital erosions


clidinium

The ester resulting from formal condensation of benzilic acid and 3-hydroxy-1-methyl-1-azoniabicyclo[2.2.2]octane. It is used, generally as the bromide, for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.


2-bromohexadecanoic acid

A bromo fatty acid that is hexadecanoic (palmitic) acid carrying a single bromo substituent at position 2.


Grade 4 Hyperkalemia, CTCAE

description: >7.0 mmol/L; life-threatening consequences


Early menarche

description: Occurrence of the first menstrual period in a female before the usual or expected age.


Isolated Premature Menarche

description: Occurrence of the first menstrual period in a girl before the lower limit of the normal age range for the reference population, without other signs of puberty.


irregular menstruation (diagnosis)

description: Deviations from the normal process; e.g. delayed, difficult, profuse, scanty, unusual bleeding, etc.


Hypomenorrhea

description: Decreased menstrual blood flow.


N-(3-oxohexanoyl)homoserine lactone

A N-acyl homoserine lactone that is the monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-oxohexanoic acid with the amino group of homoserine lactone.


campomelic dysplasia

description: Campomelic dysplasia is a very rare disorder characterized by a variable association of skeletal abnormalities (bowed and fragile long bones, pelvis and chest abnormalities, eleven rib pairs instead of the usual twelve), and extraskeletal abnormalities (facial dysmorphology, cleft palate, sexual ambiguity or sex reversal in two thirds of the affected boys, and brain, heart and kidney malformations).


name: Grade 1 Lung Thoracic Nerve Intra-Operative Injury, CTCAE


name: Grade 2 Jejunum Stricture or Stenosis, CTCAE


name: Grade 5 Jejunum Stricture or Stenosis, CTCAE


name: Grade 3 Jejunum Stricture or Stenosis, CTCAE


name: Grade 1 Jejunum Stricture or Stenosis, CTCAE


name: Grade 4 Jejunum Stricture or Stenosis, CTCAE


name: Nasopharyngeal Cancer pT2b TNM Finding v6

description: Nasopharyngeal cancer with parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor beyond the pharyngobasilar fascia. (from AJCC 6th Ed.)


An N-acylsphingosine that has omega-hydroxytriacontanoyl as the acyl group. A bioactive sphingolipid found in the stratum corneum layer of mammalian epidermis.


name: qualitative or quantitative defects of protein involved in O-glycosylation of alpha-dystroglycan


name: qualitative or quantitative defects of alpha-dystroglycan


name: autosomal recessive limb-girdle muscular dystrophy type 2U

description: Any autosomal recessive limb-girdle muscular dystrophy in which the cause of the disease is a mutation in the ISPD gene.


name: qualitative or quantitative defects of FKRP


name: qualitative or quantitative defects of protein O-mannosyltransferase 2


name: muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 7

description: Any muscular dystrophy-dystroglycanopathy, type A in which the cause of the disease is a mutation in the ISPD gene.


myopathy caused by variation in POMT2

description: Any myopathy in which the cause of the disease is a variation in the POMT2 gene.


name: limb-girdle muscular dystrophy due to POMK deficiency

description: Limb-girdle muscular dystrophy due to POMK deficiency is a form of limb-girdle muscular dystrophy presenting in infancy with muscle weakness and delayed motor development (eventually learning to walk at 18 months of age) followed by progressive proximal weakness, pseudohypertrophy of calf muscles, mild facial weakness, and borderline intelligence.


myopathy caused by variation in CRPPA

description: Any myopathy in which the cause of the disease is a variation in the CRPPA gene.


myopathy caused by variation in POMT1

description: Any myopathy in which the cause of the disease is a variation in the POMT1 gene.


name: muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A5


name: qualitative or quantitative defects of protein O-mannosyltransferase 1


name: autosomal recessive limb-girdle muscular dystrophy type 2K

description: Autosomal recessive limb-girdle muscular dystrophy type 2K (LGMD2K) is a form of limb-girdle muscular dystrophy characterized by the onset of slowly progressive proximal muscle weakness during childhood (with fatigue and difficulty running and climbing stairs) and developmental delay. Mild intellectual deficit and microcephaly, without any obvious structural brain abnormality, are found in all patients. Mild pseudohypertrophy and joint contractures of the ankles have also been reported.


name: autosomal recessive limb-girdle muscular dystrophy type 2I

description: A subtype of autosomal recessive limb-girdle muscular dystrophy that presents a highly variable age of onset and phenotypic spectrum typically characterized by slowly progressive proximal weakness of the pelvic and shoulder girdle musculature (predominantly affecting the lower limbs), frequently associated with waddling gait, scapular winging, calf and tongue hypertrophy, exercise-induced myalgia, and myoglobinuria and/or elevated creatine kinase serum levels. Abdominal muscle weakness, cardiomyopathy, respiratory muscle involvement and various brain abnormalities have also been reported.


name: autosomal recessive limb-girdle muscular dystrophy type 2N

description: Autosomal recessive limb-girdle muscular dystrophy type 2N (LGMD2N) is a form of limb-girdle muscular dystrophy characterized by proximal weakness (manifesting as slowness in running) presenting in infancy, along with calf hypertrophy, mild lordosis, scapular winging and normal intelligence or mild intellectual disability.


name: muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2

description: An autosomal recessive inherited congenital muscular dystrophy caused by mutations in the POMT2 gene. It is characterized by mental retardation and mild structural brain abnormalities resulting from defective glycosylation of alpha-dystroglycan.


name: muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1


A member of the class of piperidines that is piperidine substituted by (4-azidophenyl)methyl and 2-(diphenylmethoxy)ethyl groups at positions 1 and 4, respectively. It binds to the dopamine transporter ligand binding site.


A fatty acid ester obtained by formal condensation of the carboxy group of (9Z)-hexadecenoic acid with the hydroxy group of 13-hydroxyoctadecanoic acid.


NTRK Fusion Gene Positive

description: An indication that a fusion containing NTRK family gene sequences has been detected in a sample.


DEMETHYLKOTANIN

A member of the class of 8,8'-bicoumarins that is kotanin in which the methoxy group at position 7 is replaced by a hydroxy group. A fungal metabolite, its isolation from Aspergillus clavatus was first reported in 1971.


A bicoumarin in which the which the 8 position of one coumarin group is joined to the 8 position of the second by a single bond.


(+)-kotanin

A member of the class of 8,8'-bicoumarins resulting from the formal oxidative dimerisation of 4,7-dimethoxy-5-methyl-2H-chromen-2-one (the S-(+) enantiomer). A fungal metabolite, its isolation from Aspergillus clavatus was first reported in 1971.


orlandin

A member of the class of 8,8'-bicoumarins that is kotanin in which the methoxy groups at the 7 and 7' positions are replaced by hydroxy groups. A fungal metabolite, its isolation from Aspergillus niger was first reported in 1979.


integracin A

A benzoate ester obtained by the formal condensation of the hydroxy group of 5-(8-hydroxyundecyl)benzene-1,3-diol with 4,6-dihydroxy benzoic acid which is also substituted by a 8-(acetoxy)undecyl group at position 2. It is isolated from Cytonaema sp. and has anti-HIV-1 activity.


Broad Ligament Papillary Cystadenoma

description: A cystadenoma that arises from the broad ligament. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


A 3-oxo Delta(4)-steroid that is 3-oxochol-4-en-24-oic acid carrying an additional 7alpha-hydroxy substituent.


7-oxoglycolithocholic acid

A bile acid glycine conjugate that is glycolithocholic acid carrying an additional oxo substituent at postion 7.


name: Putative Chenodeoxycholic acid Phenylalanine conjugate


bile acid taurine conjugate

A bile acid conjugate resulting from the formal condensation of a bile acid with the amino group of taurine.


name: 3alpha,7alpha,15beta-Trihydroxy-5beta-cholane-24-oic acid methyl ester


A 3-oxo-5beta-steroid that is 7-deoxycholic acid in which the hydroxy group at position 3 has undergone formal oxidation to the corresponding ketone.


allo-bile acid

Any member of the class of bile acids having 5alpha-configuration. Usually found in lower vertebrates.


dehydrocholic acid

An oxo-5beta-cholanic acid in which three oxo substituents are located at positions 3, 7 and 12 on the cholanic acid skeleton.


tauro-beta-muricholic acid

A bile acid taurine conjugate derived from beta-muricholic acid.


A synthetic cholanoid that is a sulfonic acid analogue of chenodeoxycholic acid.


7-oxoglycodeoxycholic acid

A bile acid glycine conjugate that is glycodeoxycholic acid carrying an additional oxo substituent at position 7.


bile acid glycine conjugate

Amide of a bile acid with glycine.


5beta-cholanic acids

Members of the class of cholanic acids based on a 5beta-cholane skeleton.


cholate salt

A bile acid salt having cholate as the anionic component.


A dihydroxy-5beta-cholanic acid with hydroxy groups located at positions 3beta and 6beta.


An oxo-5beta-cholanic acid that is ursodeoxycholic acid carrying an additional oxo substituent at position 12.


An oxo-5beta-cholanic acid in which two oxo substituents are located at positions 3 and 12 together with a hydroxy substituent at position 7beta.


A monohydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by beta-hydroxy and oxo groups at positions 3 and 7 respectively.


name: Phenylalanine conjugated chenodeoxycholic acid


name: Glutamate conjugated chenodeoxycholic acid


tauroursocholic acid

A bile acid taurine conjugate of  ursocholic acid.


hydroxy-5beta-cholanic acid

Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position.


bile acid conjugate

Any bile acid conjugated to a functional group that gives additional hydrophilicity or charge to the molecule. Molecules used for conjugation are: glycine, taurine (and other amino acids); sulfuric acid (for which the term ''sulfate'' may be used); glucuronic acid (for which the term ''glucuronate'' may be used); glucose and other uncharged sugars; and coenzyme A.


name: Alanine conjugated chenodeoxycholic acid


5alpha-cholanic acid

A cholanic acid having 5alpha-configuration.


7,12-dioxolithocholic acid

A bile acid that is lithocholic acid carrying two additional oxo substituents at positions 7 and 12.


A dihydroxy-5beta-cholanic acid in which the two hydroxy groups are located at positions 3beta and 7alpha. The 3beta-hydroxy epimer of chenodeoxycholic acid.


glycohyocholic acid

A bile acid glycine conjugate having hyocholic acid as the bile acid component.


name: 3alpha,7alpha,15alpha-Trihydroxy-5beta-cholane-24-oic acid methyl ester


bisnorcholic acid

A bile acid that is 24-dinor-5beta-cholan-22-oic acid bearing three hydroxy substituents at positions 3alpha, 7alpha and 12alpha.


A trihydroxy-5beta-cholanic acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions  3, 7 and 12 (the 3alpha,7alpha,12beta stereoisomer).


dihydroxy-5beta-cholanic acid

A hydroxy-5beta-cholanic acid carrying two hydroxy groups at unspecified positions.


7-oxolithocholic acid

A bile acid that is lithocholic acid carrying an additional oxo substituent at position 7.


3-deoxychenodeoxycholic acid

A monohydroxy-5beta-cholanic acid in which the hydroxy group is located at the 7alpha-position. A structural derivative of the bile acid, chenodeoxycholic acid.


bile acid salt

A salt of a bile acid.


A 3-oxo steroid that is chenodeoxycholic acid in which the hydroxy group at position 3 has undergone formal oxidation to the corresponding ketone.


3-oxochola-4,6-dien-24-oic acid

A 3-oxo Delta(4)-steroid that is the 3-oxo derivative of chola-4,6-dien-24-oic acid.


sodium glycodeoxycholate

A bile acid salt that is the sodium salt of glycodeoxycholic acid.


A bile acid that is 5alpha-cholan-24-oic acid carrying an oxo group at position 3 and a hydroxy group at position 7beta.


A dihydroxy-5beta-cholanic acid that is deoxycholic acid with a double bond at position 6.


name: Methionine conjugated chenodeoxycholic acid


A C27 bile acid that is 5beta-cholest-24-en-26-oic acid substituted by hydroxy groups at positions 3alpha and 7beta.


name: Aspartate conjugated chenodeoxycholic acid


bile acid

Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.


name: Threonine conjugated chenodeoxycholic acid


sodium glycochenodeoxycholate

A bile acid salt that is the sodium salt of glycochenodeoxycholic acid.


bile salt

A sodium salt of the conjugate of any bile acid with either glycine or taurine.


7-oxotaurodeoxycholic acid

A bile acid taurine conjugate derived from 7-oxodeoxycholic acid.


A 3-oxo steroid that is cholic acid in which the hydroxy group at position 3 has undergone formal oxidation to the corresponding ketone.


name: Cysteine conjugated chenodeoxycholic acid


bile acid hydroxylation conjugate

A bile acid conjugate that contains hydroxy groups.


isoursodeoxycholic acid

A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by beta-hydroxy groups at positions 3 and 7.


A dihydroxy-5beta-cholanic acid in which the two hydroxy groups are located at positions 3beta and 12alpha. The 3beta-hydroxy epimer of deoxycholic acid.


bile acid glucuronide conjugate

A bile acid which is conjugated to glucoronic acid.


1beta-hydroxydeoxycholic acid

A trihydroxy-5beta-cholanic acid in which the three hydroxy groups are located at positions 1beta, 3alpha, and 12alpha.


A trihydroxy-5beta-cholanic acid in which the three hydroxy groups are located at positions 3alpha, 7alpha and 12alpha together with a methyl substituent, with S-configuration, at position 23.


LITHOGLYCOCHOLATE

The glycine conjugate of lithocholic acid.


dihydroxycholanic acid

Any member of the class of cholanic acids carrying two hydroxy substituents at unspecified positions.


7-oxotaurolithocholic acid

A bile acid taurine conjugate derived from 7-oxolithocholic acid.


bile acid sulfate conjugate

A bile acid which is conjugated to a sulfate group.


name: Grade 5 Fibrosis-Deep Connective Tissue, CTCAE


name: Malignant Neoplasm of Right Testis, Unspecified whether Descended or Undescended

description: Evidence of a malignant neoplasm of the right testis, unspecified whether descended or undescended.


Cervical Warty Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of a warty surface and koilocytotic atypia.


dehydroluciferin

A member of the class of 1,3-thiazolemonocarboxylic acids that is 1,3-thiazole-4-carboxylic acid in which the hydrogen at position 2 has been replaced by a 6-hydroxy-1,3-benzothiazol-2-yl group.


name: [[2-[(4,5-dimethyl-2-thiazolyl)amino]-2-oxoethyl]thio]methanethioic acid O-ethyl ester


Grade 1 Rectal Mucositis, CTCAE

description: Asymptomatic or mild symptoms; intervention not indicated


A glycodihydroceramide having an alpha-D-glucuronic acid residue at the O-1 position and a tetradecanoyl group attached to the nitrogen.


Tumor cells, malignant

category: biolink:Cell biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Cells of, or derived from, a malignant tumor.


name: Malignant Thyroid Gland Follicular Clear Cell


pseudohypoaldosteronism type 2D

description: Any pseudohypoaldosteronism type 2 in which the cause of the disease is a mutation in the KLHL3 gene.


Local disease

description: A disease that is confined to a specific organ or tissue and has not spread to other anatomic sites.


name: Ocular Adnexal Lymphoma pT4b TNM Finding v7

description: Osseous involvement (including periosteum).  (from AJCC 7th Ed.)


Craniomandibular Disorders

description: A disorder that affects the muscles of head and neck and temporomandibular joint.


osteofibrous dysplasia

description: A benign, usually self-limited fibro-osseous lesion of the bone that affects infants and children. It usually arises from the cortical bone of the anterior mid-shaft of the tibia. Patients usually present with swelling or painless bowing of the tibia. Progression to adamantinoma has been reported in some cases.


name: 3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid methyl ester


glycerophosphoinositol bisphosphate

Any glycerophosphoinositol bearing two additional phospho substituents on the inositol ring.


name: Grade 3 Anus Stricture or Stenosis, CTCAE


malvidin 3-O-beta-D-glucoside betaine

An oxonium betaine obtained by deprotonation of the hydroxy group at the 5 position of malvidin 3-O-beta-D-glucoside. It is the major microspecies at pH 7.3.


oxonium betaine

Neutral molecules having charge-separated forms with an oxonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


cyanidin 3-O-rutinoside betaine

An oxonium betaine that is the conjugate base of cyanidin 3-O-rutinoside, arising from selective deprotonation of the 5-hydroxy group on the chromene ring; major species at pH 7.3.


A conjugate base of delphinidin 3-O-rutinoside-7-O-beta-D-glucoside arising from selective deprotonation of the 5-hydroxy group; major species at pH 7.3.


cyanin betaine

An oxonium betaine that is the conjugate base of cyanin, arising from regioselective deprotonation of the 7-hydroxy group. Major structure at pH 7.3


An oxonium betaine obtained by deprotonation of the 7-hydroxy group of delphinidin 3,3',5-tri-O-beta-D-glucoside. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


anthocyanidin 3,5-diglucoside betaine

The oxonium betaine of anthocyanidin 3,5-diglucoside arising from selective deprotonation of the 7-hydroxy group.


pelargonidin 3-O-rutinoside betaine

The conjugate base of pelargonidin 3-O-rutinoside; major species at pH 7.3.


name: pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside betaine

description: The conjugate base of pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside; major species at pH 7.3.


name: anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside betaine

description: An oxonium betaine that is the conjugate base of any anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside and is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


An oxonium betaine obtained by deprotonation of the 5 position of delfinidin 3-O-beta-D-glucoside. It is the major microspecies at pH 7.3.


name: anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] betaine

description: An oxonium betaine obtained by deprotonation of the 7-hydroxy group of anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-4-hydroxycinnamoyl)glucoside]. It is the major microspecies at pH 7.3


An organic betaine obtained by deprotonation of the hydroxy group at the 5 position of pelargonidin 3-O-beta-D-glucoside. It is the major microspecies at pH 7.3.


Major microspecies at pH 7.3.


malvidin 3-O-beta-D-galactoside betaine

Major microspecies at pH 7.3.


name: cyanidin 3-O-rutinoside 5-O-beta-D-glucoside betaine

description: Conjugate base of cyanidin 3-O-rutinoside 5-O-beta-D-glucoside arising from selective deprotonation of the 7-hydroxy group; major species at pH 7.3.


anthocyanidin 3-O-sophoroside betaine

An oxonium betaine obtained by deprotonation of the 5-hydroxy group of any anthocyanidin 3-O-sophoroside. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


An oxonium betaine arising from regioselective deprotonation of the 5-hydroxy group of any anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] (R groups may be H).


An oxonium betaine obtained by deprotonation of the 5-hydroxy group of any anthocyanidin 3-O-beta-D-sambubioside. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


peonidin 3-O-beta-D-glucoside betaine

An oxonium betaine obtained by deprotonation of the 5 position of peonidin 3-O-beta-D-glucoside. It is the major microspecies at pH 7.3.


petunidin 3-O-beta-D-glucoside betaine

Major microspecies at pH 7.3.


name: pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside betaine

description: Conjugate base of pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside.


3-hydroxyanthocyanidin betaine

An oxonium betaine obtained by deprotonation of the 3-hydroxy group of any 3-hydroxyanthocyanidin cation. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


name: anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside betaine

description: An oxonium betaine obtained by deprotonation of the 7-hydroxy group of any anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


anthocyanidin betaine

Major species at pH 7.3. The structure is based on the fact that all (except one; see Wikipedia page for anthocyanidin) anthocyanidins have OH groups at positions 3,5,7,4' and can be substituted at positions 3' and 5'


Any 3-hydroxyanthocyanidin betaine that lacks a substituent at position 4.


peonidin 3-O-beta-D-galactoside betaine

Major microspecies at pH 7.3.


The oxonium betaine of anthocyanidin 3,5-di-O-beta-D-glucoside arising from selective deprotonation of the 7-hydroxy group.


cyanidin 3-O-beta-D-galactoside betaine

An oxonium betaine that is the conjugate base of cyanidin 3-O-beta-D-galactoside, arising from regioselective deprotonation of the 5-hydroxy group. Major structure at pH 7.3


An oxonium betaine that is the conjugate base of cyanidin 3,7-di-O-beta-D-glucoside, arising from regioselective deprotonation of the 5-hydroxy group. Major structure at pH 7.3


An oxonium betaine obtained by deprotonation of the carboxy group of any anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside). It is the major microspecies at pH 7.3.


cyanidin 3-O-beta-D-glucoside betaine

An oxonium betaine that is the conjugate base of cyanidin 3-O-beta-D-glucoside, arising from selective deprotonation of the 5-hydroxy group on the chromene ring; major species at pH 7.3.


An oxonium betaine obtained by deprotonation of the 5-hydroxy group of cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside). It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


An oxonium betaine obtained by deprotonation of the 7-hydroxy group of delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


name: anthocyanidin 3-glucoside 5-[(6-O-4-hydroxycinnamoyl)glucoside] betaine

description: An oxonium betaine obtained by deprotonation of the 7-hydroxy group of anthocyanidin 3-glucoside 5-[(6-O-4-hydroxycinnamoyl)glucoside]. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).


name: Perihilar Bile Duct Cancer pM1 TNM Finding v8

description: Perihilar bile duct cancer with distant metastasis. (from AJCC 8th Ed.)


Stage IIIC Ovarian Cancer

description: Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0). T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage IIIB Ovarian Germ Cell Tumor AJCC v6 and v7

description: Stage IIIB includes: T3b, N0, M0. T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIB Ovarian Cancer AJCC v8

description: Stage IIB includes: T2b, N0, M0. T2b: Ovarian cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IIIA Ovarian Cancer AJCC v6 and v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Ovarian Sex Cord-Stromal Tumor, Not Otherwise Specified

description: A sex cord-stromal tumor that arises from the ovary and lacks the morphologic features that belong to the categories of granulosa-stromal tumors, Sertoli-stromal tumors, or steroid cell tumors.


name: Recurrent Malignant Ovarian Brenner Tumor

description: The reemergence of malignant ovarian Brenner tumor after a period of remission.


name: Stage IC Ovarian Germ Cell Tumor AJCC v6 and v7

description: Stage IC includes: (T1c, N0, M0).  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: DICER1-Mutant Ovarian Sertoli-Leydig Cell Tumor

description: Ovarian Sertoli-Leydig cell tumor characterized by the presence of DICER1 gene mutation. It is associated with moderately and poorly differentiated histological features, presence of retiform or heterologous elements, and younger age.


FIGO Stage IIIA2 Ovarian Cancer

description: Ovarian cancer with microscopic, extrapelvic (above the brim) peritoneal involvement +/- positive retroperitoneal lymph nodes. (FIGO, 2014)


name: ovarian endometrioid stromal and related neoplasms

description: A category of rare neoplasms that arise from the ovary. It includes low grade endometrioid stromal sarcoma and undifferentiated sarcoma.


Ovarian Neuroendocrine Carcinoma

description: A small cell carcinoma, pulmonary-type or large cell neuroendocrine carcinoma arising from the ovary.


name: Borderline Ovarian Mucinous Tumor/Atypical Proliferative Ovarian Mucinous Tumor with Microinvasion

description: A low grade ovarian epithelial neoplasm characterized by the presence of neoplastic mucinous epithelial cells, atypia, and microinvasion of the ovarian stroma.


name: Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


name: Borderline Ovarian Mixed Epithelial Tumor/Atypical Proliferative Ovarian Mixed Epithelial Tumor

description: A low grade, non-invasive mixed epithelial proliferative neoplasm that arises from the ovary. In most cases is composed of serous and endocervical-type mucinous cells.


Stage IV Ovarian Cancer AJCC v6 and v7

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


name: Metastatic Ovarian Clear Cell Adenocarcinoma

description: Ovarian clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Stage IIB Ovarian Germ Cell Tumor AJCC v6 and v7

description: Stage IIB includes: T2b N0, M0. T2b: Extension and/or implants on other pelvic tissues. No malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


FIGO Stage IVA Ovarian Cancer

description: Ovarian cancer with pleural effusion with positive cytology. (FIGO, 2014)


Borderline Ovarian Mucinous Tumor

description: A low grade mucinous epithelial neoplasm arising from the ovary.  It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion.  The mucinous epithelial cells may be of intestinal or endocervical type.


name: Locally Advanced Platinum-Refractory Ovarian Carcinoma

description: Platinum-refractory ovarian carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Ovarian Transitional Cell Carcinoma

description: The reemergence of ovarian transitional cell carcinoma after a period of remission.


Stage IIIC Ovarian Cancer AJCC v8

description: Stage IIIC includes: T3c, N0/N1, M0. T3c: Ovarian cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Ovarian Mixed Cell Adenocarcinoma

description: An adenocarcinoma that arises from the ovary and is characterized by the presence of two or more adenocarcinoma components, most often endometrioid and clear cell.


name: Stage III Childhood Ovarian Germ Cell Tumor by Toronto Guidelines v2

description: Tumor involves one or both ovaries with cytologically or histologically confirmed spread to the peritoneum outside the pelvis and/or metastasis to the retroperitoneal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Ovarian Fibroma

description: A fibroma that arises from the ovary during childhood.


Locally Advanced Ovarian Carcinoma

description: Ovarian carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Childhood Ovarian Small Cell Carcinoma, Hypercalcemic Type

description: A rare ovarian small cell carcinoma, hypercalcemic type that occurs during childhood.


name: Recurrent Ovarian Undifferentiated Carcinoma

description: The reemergence of ovarian undifferentiated carcinoma after a period of remission.


name: Childhood Ovarian Germ Cell Tumor by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood ovarian germ cell tumor according to the Toronto childhood cancer staging guidelines v2.


Ovarian Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm of the ovary. Representative examples include leiomyoma, myxoma, and sarcoma.


ovarian stromal hyperthecosis

description: A non-neoplastic disorder that usually affects postmenopausal women. It is characterized by the leuteinization of ovarian stromal cells. The ovaries are bilaterally involved and enlarged. When it affects women in reproductive age, it causes virilization, high blood pressure, and increased insulin levels.


Metastatic Ovarian Carcinosarcoma

description: Ovarian carcinosarcoma that has spread from its original site of growth to another anatomic site.


name: Stage I Ovarian Germ Cell Tumor AJCC v6 and v7

description: Stage I includes: (T1, N0, M0). T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: DICER1/FOXL2-Wildtype Ovarian Sertoli-Leydig Cell Tumor

description: Ovarian Sertoli-Leydig cell tumor characterized by the absence of DICER1 and FOXL2 gene mutations. It is associated with well-differentiated histological features, absence of retiform or heterologous elements, and intermediate age.


name: malignant sex cord stromal tumor of ovary

description: Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis.


Stage IIIB Ovarian Cancer AJCC v8

description: Stage IIIB includes: T3b, N0/N1, M0. T3b: Ovarian cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage II Borderline Ovarian Surface Epithelial-Stromal Tumor

description: Stage II includes: T2, N0, M0.  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


ovary rhabdomyosarcoma

description: A malignant mesenchymal tumor with skeletal muscle differentiation affecting the ovaries.


Ovarian Mucinous Carcinoid Tumor

description: A rare carcinoid tumor that arises from the ovary and is characterized by the presence of glands that are lined by cells that contain intracytoplasmic mucin or resemble goblet cells.  Pools of mucin, containing glands, may also be present.  It may have an aggressive clinical course and it can metastasize to other anatomic sites.


ovarian Sertoli-Leydig cell tumor

description: A benign or malignant sex cord-stromal tumor arising from the ovary. It is characterized by the presence of neoplastic Leydig cells. Signs and symptoms include hirsutism, menorrhagia and metrorrhagia. It may be associated with trisomy 8.


name: Well Differentiated Ovarian Steroid Cell Tumor

description: An ovarian steroid cell tumor not otherwise specified, and characterized by the absence of nuclear atypia, mitotic figures, necrosis, and hemorrhage.


name: Refractory Ovarian Clear Cell Adenocarcinoma

description: Ovarian clear cell adenocarcinoma that is resistant to treatment.


Ovarian Wolffian Tumor

description: An epithelial neoplasm of Wolffian (mesonephric) origin arising from the ovarian hilum. Most tumors behave in a benign fashion.


Ovarian Stromal-Leydig Cell Tumor

description: A rare, benign and well circumscribed stromal tumor of the ovary.  It is characterized by the presence of a fibrotic stroma with clusters of Leydig cells.  The Leydig cells contain crystals of Reinke.  Patients may present with virilization.


Stage IIA Ovarian Cancer AJCC V6 and v7

description: Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or implants on uterus and/or tube(s). No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


non-gestational ovarian choriocarcinoma

description: A malignant germ cell tumor that arises from the ovary and is composed of cytotrophoblasts, syncytiotrophoblasts, and extravillous trophoblasts. The prognosis is less favorable than gestational choriocarcinoma.


name: Stage IB Ovarian Germ Cell Tumor AJCC v6 and v7

description: Stage IB includes: (T1b, N0, M0). T1b: Tumor limited to both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Recurrent Low Grade Ovarian Endometrioid Adenocarcinoma

description: The reemergence of ovarian low-grade endometrioid adenocarcinoma after a period of remission.


name: Borderline Ovarian Clear Cell Tumor/Atypical Proliferative Ovarian Clear Cell Tumor with Intraepithelial Carcinoma

description: A non-invasive clear cell adenofibromatous neoplasm that arises from the ovary. It is characterized by the presence of atypical neoplastic clear or hobnail epithelial cells and intraepithelial carcinoma.


FIGO Stage IIIA1(i) Ovarian Cancer

description: Ovarian cancer with positive retroperitoneal lymph nodes only. Metastasis equal or less than 10 mm. (FIGO, 2014)


name: malignant non-dysgerminomatous germ cell tumor of ovary

description: A malignant germ cell tumor other than dysgerminoma that arises from the ovary.


Malignant Ovarian Luteinized Thecoma

description: A thecoma of the ovary that contains lutein cells and may metastasize to other anatomic sites. It is usually characterized by nuclear atypia and mitotic activity.


ovarian angiosarcoma

description: A malignant vascular neoplasm arising from the ovary.


name: Stage II Ovarian Polyembryoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor involves one or both ovaries with pelvic extension and/or implants. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage I Borderline Ovarian Surface Epithelial-Stromal Tumor

description: Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Stage IIIA Ovarian Germ Cell Tumor AJCC v6 and v7

description: Stage IIIA includes: T3a, N0, M0. T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Ovarian Carcinosarcoma

description: The reemergence of ovarian carcinosarcoma after a period of remission.


Childhood Malignant Ovarian Neoplasm

description: A malignant neoplasm that affects the ovary and occurs during childhood.


name: Ovarian germ cell choriocarcinoma stage II


name: Recurrent BRCA- Associated Ovarian Carcinoma

description: The reemergence of BRCA-associated ovarian carcinoma after a period of remission.


ovarian endometriosis

description: A non-neoplastic disorder characterized by the growth of endometrial tissue in the ovaries. It results in the development of blood filled ovarian cysts (chocolate cysts), and creation of scars and adhesions.


name: Borderline Ovarian Serous Tumor/Atypical Proliferative Ovarian Serous Tumor

description: A non-invasive serous neoplasm that arises from the ovary and shows greater cellular proliferation and cytologic atypia as compared to benign ovarian serous tumors, but less as compared to low-grade ovarian serous carcinoma.


ovarian gynandroblastoma

description: A rare neoplasm arising from the ovary. Although it may occur at any age, it is more often seen in young females. Morphologically, it is characterized by a mixture of two cellular populations: well differentiated Sertoli cells and granulosa cells, with the latter constituting at least ten percent of the neoplasm. The vast majority of cases are stage I lesions at presentation and produce either estrogenic or androgenic manifestations. Although it may present as a massive ovarian tumor, it usually follows a benign clinical course. Very rare case reports of testicular lesions morphologically resembling gynandroblastomas are in fact variants of juvenile granulose cell tumor, or Sertoli cell tumor, or a combination of both.


name: Stage IIIB Ovarian Cancer AJCC v6 and v7

description: Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Refractory Extrarenal Rhabdoid Tumor of the Ovary

description: An extrarenal rhabdoid tumor of the ovary that is resistant to treatment.


name: FOXL2 c.402C>G (p.Cys134Trp)-Mutant Ovarian Sertoli-Leydig Cell Tumor

description: Ovarian Sertoli-Leydig cell tumor characterized by mutation at position 402 of the coding sequence of the FOXL2 gene where cytosine has been replaced by guanine. It is associated with moderately and poorly differentiated histological features and absence of retiform or heterologous elements. It is described in postmenopausal patients.


name: Refractory Ovarian Squamous Cell Carcinoma

description: Ovarian squamous cell carcinoma that is resistant to treatment.


Benign epithelial tumor of ovary

description: A neoplasm that arises from the surface epithelium of the ovary and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include serous cystadenoma, mucinous cystadenoma, clear cell adenofibroma, and benign Brenner tumor.


ovarian adenosarcoma

description: A biphasic neoplasm that arises from the ovary and is characterized by the presence of mullerian-type epithelial tissue in a mesenchymal sarcomatous stroma. The presence of a high grade sarcomatous component is associated with recurrences and metastases.


name: Stage IV Ovarian Polyembryoma AJCC v6 and v7

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.)


name: Ovarian germ cell choriocarcinoma stage I

description: Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Ovarian Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from the ovary and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


name: Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor

description: A Sertoli-Leydig tumor of the ovary characterized by the presence of a sarcomatoid stroma which contains primitive gonadal stromal cells. It may behave in a malignant fashion and metastasize to other anatomic sites.


Malignant Ovarian Thecoma

description: A thecoma of the ovary which may metastasize to another anatomic site. It is usually characterized by nuclear atypia and mitotic activity. Malignant thecomas are rare.


name: Ovarian Mucinous Cystic Tumor Associated with Pseudomyxoma Peritonei

description: The presence of abundant mucoid or gelatinous, cellular or acellular material in the pelvis and abdominal cavity (pseudomyxoma peritonei) that is associated with the presence of an ovarian mucinous cystic tumor.  In the vast majority of cases, the presence of pseudomyxoma peritonei is the result of metastasis from a primary appendiceal or gastrointestinal tumor site, and the ovarian mucinous tumor is metastatic rather than primary.


Ovarian Cancer by AJCC v8 Stage

description: A term that refers to the staging of ovarian cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ovarian carcinomas. Nonepithelial primary ovarian cancers may be staged using this classification but should be reported separately. (from AJCC 8th Ed.)


Ovarian Signet Ring Stromal Tumor

description: A rare, benign sex cord-stromal tumor that arises from the ovary. It is characterized by the presence of round cells with a single cytoplasmic vacuole and an eccentric nucleus resembling signet ring cells. Mucin stains are negative.


name: Stage I Ovarian Dysgerminoma AJCC v6 and v7

description: Stage I includes: (T1, N0, M0). T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Recurrent Ovarian Adenocarcinoma

description: The reemergence of ovarian adenocarcinoma after a period of remission.


Ovarian Seromucinous Cystadenoma

description: A non-metastasizing cystic mixed epithelial neoplasm that arises from the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous.


name: FIGO Grade 2 Ovarian Endometrioid Adenocarcinoma

description: Ovarian  endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


Ovarian Smooth Muscle Neoplasm

description: A benign, intermediate, or malignant neoplasm that arises from the ovary and is composed of neoplastic cells with smooth muscle differentiation.


name: Ovarian Low Grade Endometrioid Stromal Sarcoma

description: A rare invasive mesenchymal tumor that arises from the ovary.  It is characterized by the absence of marked pleomorphism and nuclear atypia in the neoplastic mesenchymal cells.  It may have a favorable clinical outcome.


name: Ovarian Sertoli Cell Tumor with Lipid Storage

description: A Sertoli cell tumor that arises from the ovary and is characterized by the presence of cells that are distended by the presence of intracytoplasmic lipid.


pediatric ovarian germ cell tumor

description: A germ cell tumor that arises from the ovary and occurs in children.


Ovarian Mesonephric-Like Adenocarcinoma

description: An exceedingly rare adenocarcinoma that arises from the ovary and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


name: Recurrent Malignant Ovarian Granulosa Cell Tumor

description: The reemergence of malignant ovarian granulosa cell tumor after a period of remission.


name: Refractory Ovarian Transitional Cell Carcinoma

description: Ovarian transitional cell carcinoma that is resistant to treatment.


Stage I Ovarian Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Benign Ovarian Seromucinous Tumor

description: A non-metastasizing mixed epithelial neoplasm that arises from the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous. There is no evidence of atypia. This category includes seromucinous cystadenoma and seromucinous adenofibroma.


name: Stage I Childhood Ovarian Germ Cell Tumor by Toronto Guidelines v2

description: Tumor confined to ovaries (one or both). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Ovarian Carcinoid Tumor

description: A rare, well-differentiated neuroendocrine neoplasm that arises from the ovary.


Ovarian cancer stage III

description: Stage III includes: T3, N0, M0.  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Borderline Ovarian Endometrioid Adenofibroma

description: An epithelial neoplasm that arises from the ovary characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion.


name: Stage IIA Ovarian Germ Cell Tumor AJCC v6 and v7

description: Stage IIA includes: T2a, N0, M0. T2a: Extension and/or implants on uterus and/or tube(s). No malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


FIGO Stage IC1 Ovarian Cancer

description: Stage IC ovarian cancer with surgical spill. (FIGO, 2014)


ovarian primitive germ cell tumor

description: A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component.


Ovarian Cancer by FIGO Stage

description: A category of staging terms for ovarian cancer according to the International Federation of Gynecology and Obstetrics (FIGO), 2014. AJCC ovarian cancer stage terms from the 6th and 7th editions that are synonymous to the FIGO ovarian cancer staging classification of 2014 are included as preferred terms.


name: Metastatic Ovarian Endometrioid Adenocarcinoma

description: Ovarian endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site.


Platinum-Refractory Ovarian Carcinoma

description: Ovarian carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


liposarcoma of the ovary

description: A malignant adipose tissue neoplasm of the ovary.


name: Borderline Ovarian Seromucinous Tumor/Atypical Proliferative Ovarian Seromucinous Tumor with Microinvasion

description: A low grade ovarian epithelial neoplasm characterized by the presence of atypical neoplastic serous and mucinous cells. Microinvasion of the ovarian stroma is present.


Benign germ cell tumor of ovary

description: A germ cell tumor that arises from the ovary. There is no evidence of atypia or metastases. The vast majority of cases are benign dermoid cysts.


Ovarian Sertoli Cell Tumor

description: A rare, typically benign ovarian neoplasm composed of Sertoli cells. Patients may present with pseudoprecocity, menometrorrhagia, amenorrhea, hirsutism, and hoarseness.  Rarely it may invade the ovarian stroma and extend beyond the ovary.


FIGO Stage IIIC Ovarian Cancer

description: Ovarian cancer with macroscopic, extrapelvic, peritoneal metastasis greater than 2 cm +/- positive retroperitoneal lymph nodes. Includes extension to capsule of liver/spleen. (FIGO, 2014)


childhood choriocarcinoma of the ovary

description: A non-gestational choriocarcinoma that arises from the ovary and occurs in children.


name: Metastatic Ovarian Small Cell Carcinoma, Hypercalcemic Type

description: A primary small cell carcinoma of the ovary that is associated with hypercalcemia and has metastasized to other anatomic sites.


name: Borderline Ovarian Endometrioid Tumor/Atypical Proliferative Ovarian Endometrioid Tumor

description: An epithelial neoplasm that arises from the ovary characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells. The surrounding ovarian stroma is often fibrotic. There is no evidence of stromal invasion.


name: Borderline Ovarian Serous Tumor/Atypical Proliferative Ovarian Serous Tumor with Microinvasion

description: A low grade ovarian epithelial neoplasm characterized by the presence of neoplastic serous epithelial cells, atypia, and microinvasion of the ovarian stroma.


Ovarian Cellular Fibroma

description: A benign neoplasm arising from soft tissue of the ovary. It is characterized by the presence of spindle-shaped fibroblasts and increased cellularity.


name: Borderline Ovarian Seromucinous Tumor/Atypical Proliferative Ovarian Seromucinous Tumor

description: A low grade, non-invasive ovarian epithelial neoplasm characterized by the presence of atypical neoplastic serous and mucinous cells.


Benign Ovarian Serous Tumor

description: A non-metastasizing neoplasm that arises from the ovary and is characterized by the presence of neoplastic epithelium that resembles the epithelium of the fallopian tube. There is no evidence of atypia.  It includes serous cystadenoma, serous adenofibroma, serous cystadenofibroma, and surface papilloma.


name: Moderately Differentiated Ovarian Sertoli-Leydig Cell Tumor

description: A Sertoli-Leydig cell tumor of the ovary characterized by the presence of spindle-shaped gonadal stromal cells and Sertoli cells, some of which are atypical. Leydig cells are also present forming clusters at the periphery of the cellular aggregates. Metastases have been reported in a minority of patients.


name: Recurrent Borderline Ovarian Surface Epithelial-Stromal Tumor

description: The reemergence of borderline ovarian epithelial tumor after a period of remission.


Ovarian Adenomatoid Tumor

description: A rare benign mesothelial tumor that arises from the ovary. It is characterized by the presence of gland-like structures.


name: Ovarian Sex Cord-Stromal Tumor Associated with Peutz-Jeghers Syndrome

description: A sex cord-stromal tumor that arises from the ovary in a patient diagnosed with Peutz-Jeghers syndrome.


name: Stage III Ovarian Polyembryoma AJCC v6 and v7

description: Stage III includes: T3, N0, M0. T3: Tumor involves one or both both ovaries with microscopically confirmed peritoneal metastasis outside pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Juvenile Bilateral Ovarian Granulosa Cell Tumor

description: A juvenile granulosa cell tumor that involves both ovaries.


Refractory Ovarian Adenocarcinoma

description: Ovarian adenocarcinoma that is resistant to treatment.


name: Stage II Childhood Ovarian Germ Cell Tumor by Toronto Guidelines v2

description: Tumor involves one or both ovaries with pelvic extension (below the pelvic brim). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


ovarian dysfunction

description: The inability of the ovaries to function.


name: Stage III Ovarian Dysgerminoma AJCC v6 and v7


Ovarian Fibromatosis and Massive Edema

description: A rare benign lesion characterized by tumor-like enlargement of the ovaries due to fibroblastic proliferation with collagen deposition (fibromatosis) or stromal accumulation of edema fluid (massive edema). It presents in premenopausal patients, with menstrual abnormalities, abdominal pain, or androgenic manifestations. Most cases are unilateral. (WHO 2020)


luteoma of pregnancy

description: A non-neoplastic and self-limited condition that occurs during pregnancy. It is characterized by proliferation of luteinized stromal cells that replace the normal ovarian stromal cells. It is usually manifested with bilateral multinodular ovarian masses. Treatment is not required.


name: Ovarian Sertoli-Leydig Cell Tumor with Heterologous Elements

description: A Sertoli-Leydig cell tumor that arises from the ovary. It is characterized by the presence of epithelial and/or mesenchymal components and neoplasms that arise from these components.


Microsatellite Stable Ovarian Carcinoma

description: Ovarian carcinoma characterized by the absence of microsatellite instability.


Ovarian Trabecular Carcinoid Tumor

description: A carcinoid tumor that arises from the ovary and is characterized by the presence of columnar cells with abundant cytoplasm forming ribbons.  The prognosis is excellent.


Childhood Ovarian Gynandroblastoma

description: An ovarian gynandroblastoma that occurs during childhood.


name: Mucinous adenofibroma of borderline malignancy

description: A low malignant potential adenofibroma of the ovary It is characterized by an atypical epithelial hyperplasia. The epithelial cells contain intracytoplasmic mucin. There is no evidence of stromal destructive invasion.


Stage IC Ovarian Cancer AJCC v6 and v7

description: Stage IC includes: T1c, N0, M0. T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Refractory Malignant Ovarian Brenner Tumor

description: Malignant ovarian Brenner tumor that is resistant to treatment.


Stage IIB Ovarian Cancer AJCC v6 and v7

description: Stage IIB includes: T2b N0, M0.  T2b: Extension and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Clear cell adenofibroma of borderline malignancy

description: An epithelial neoplasm with low malignant potential affecting the ovary. It is characterized by the presence of atypical glands and/or cystic spaces lined with clear or hobnail cells.


Stage IB Ovarian Cancer AJCC v6 and v7

description: Stage IB includes: T1b, N0, M0. T1b: Tumor limited to both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Borderline Ovarian Serous Cystadenofibroma

description: A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of cystic spaces which are lined by atypical serous epithelial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion.


name: Recurrent High Grade Ovarian Endometrioid Adenocarcinoma

description: The reemergence of ovarian high-grade endometrioid adenocarcinoma after a period of remission.


Hilus cell tumor

description: A benign Leydig cell tumor which arises in the hilar area of the ovary.


Benign Brenner Tumor

description: A benign neoplasm that arises from the ovary and is composed of nests of neoplastic urothelial-type cells in a fibrotic stroma. There is no evidence of atypia or invasion.