ELAEODENDROSIDE T

A steroid lactone isolated from Elaeodendron tangenala and exhibits antiproliferative activity against A2780 human ovarian cancer cells.


A furonaphthodioxole that is 4'-demethyldeoxypodophyllotoxin which is substituted at position 4 of the C-ring by a 2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl group. While structurally related to etoposide, TOP-53 is significantly more toxic to non-small cell lung cancer cells, more active at generating chromosomal breaks, and displays improved cellular uptake and pharmacokinetics in animal lung tissues.


bihapten 1 dimethyl ether

A butan-4-olide having a methylidene group at the 3-position and a 9-(2,3-dimethoxyphenyl)nonyl substituent at the 5-position.


A 5-oxo-2-furylacetic acid having a 3-methyl substituent.


artemoin B

An artemoin in which the two hydroxy groups on the C-30 side-chain are located at positions 17 and 18.


MICRODIPLODIASONE

An organic heterobicyclic compound that is 2,3-dihydro-4H-chromen-4-one substituted by hydroxy groups at positions 5 and 7, a methyl group at position 2 and a 5-oxotetrahydrofuran-2-yl group at position 2. Isolated from the endophytic fungus Microdiplodia species, it exhibits antibacterial activity.


A gamma-lactone that is 5-(hydroxymethyl)furan-2(5H)-one substituted at positions 3 and 4 by hydroxy groups (the 5R-stereoisomer).


plakortone N

An organic heterobicyclic compound consisting of a gamma-lactone ring fused onto a substituted tetrahydrofuran ring. It is isolated from the Australian marine sponge Plakinastrella clathrata.


A butan-4-olide having a 1-thiocyanatoethyl group at the 3-position and two methyl substituents at the 5-position.


sedanonic acid lactone

A member of the class of 2-benzofurans that is 4,5,6,7-tetrahydro-2-benzofuran-1(3H)-one carrying an additional butylidene substituent at position 3.


firocoxib

An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs.


A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one in which all or the hydrogens attached to the benzene ring are replaced by chlorines. A fungicide used for the control of rice blast, it is not approved for use within the European Union.


(R)-ofurace

A 2-chloro-N-(2,6-dimethylphenyl)-N-(2-oxotetrahydrofuran-3-yl)acetamide that is the R-enantiomer of ofurace.


ASPULVINONE E

A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts a Z-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity.


A butan-4-olide that is gamma-butyrolactone substituted by a butyl group at position 4.


dihydrocanadensolide

A member of the class of furofurans that is tetrahydrofuro[3,4-b]furan-2,4-dione substituted at positions 3 and 6 by methyl and butyl groups respectively (the 3R,3aR,6S,6aS-stereoisomer).


A butan-4-olide that is gamma-butyrolactone substituted by an ethoxy group at position 5.


SANGUINOLIGNAN C

A  lignan isolated from the leaves of Piper sanguineispicum.


asperlactone

A member of the class of butenolides that is furan-2(5H)-one substituted by (2S,3S)-3-methyloxiran-2-yl and (1S)-1-hydroxyethyl group at positions 3 and 5R, respectively. It is a secondary metabolite isolated from Aspergillus ochraceus that exhibits antifungal and antibacterial properties.


butyrolactone II

Major microspecies at pH 7.3


gamma-caprolactone

A gamma-lactone that is oxolan-2-one substituted by an ethyl group at position 5.


PARAMINABEOLIDE D

A withanolide that is 23,26-epoxyergosta-1,4-diene substituted by a hydroxy group at position 22 and oxo groups at positions 3 and 26. Isolated from a Formosan soft coral Paraminabea acronocephala, it has been found to inhibit the accumulation of the pro-inflammatory iNOS protein.


artemoin A

An artemoin in which the two hydroxy groups on the C-30 side-chain are located at positions 19 and 20.


A butan-4-olide that is gamma-valerolactone in which one of the methyl hydrogens has been replaced by a 3-sulfooxy-4-hydroxyphenyl group.


An organic heterohexacyclic compound that is isolated from Streptomyces sp. A54238. It exhibits inhibitory efficacy against the growth of human tumour cells.


plakortolide L

An organic heterobicyclic compound that is a cyclic peroxy compound isolated from the Australian marine sponge Plakinastrella clathrata.


A butenolide that is furan-2(5H)-one substituted by a methyl group at position 3 and a hydroxy group at position 4.


carlosic acid

A tetronic acid derivative that is furan-2(5H)-one which is substituted at positions 3, 4, and 5 by butanoyl, hydroxy, and carboxymethyl groups, respectively (the S enantiomer).


A butan-4-olide having a bromomethyl group at the 3-position and two methyl substituents at the 5-position.


THUNBERGINOL F

An isobenzofuranone that is 2-benzofuran-1(3H)-one substituted by a hydroxy group at position 7 and a 3,4-dihydroxybenzylidene group at position 3. It has been isolated from the roots of  Scorzonera judaica.


EUTYPOID B

A  butenolide that is furan-2(5H)-one substituted by a 4-hydroxybenzyl group at position 4 and a 4-hydroxyphenyl group at position 3. It has been isolated from Penicillium species.


MATAIRESINOSIDE

A lignan that is (-)-matairesinol in which one of the phenolic hydroxy groups has been replaced by a beta-D-glucosyl residue.


homoserine lactone

A butan-4-olide having an amino substituent at the 2-position.


N-butyryl-L-homoserine lactone

An N-acyl-L-homoserine lactone having butyryl as the acyl substituent.


seco-plakortolide K

A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 4, a 2-hydroxy-2-methyl-14-phenyltetradecyl group at position 5 and a methyl group at position 5 (the 4R,5R stereoisomer). It is isolated from the Australian marine sponge Plakinastrella clathrata.


agglomerin F

A butenolide that is the methyl ester of 4-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-4-oxobutanoic acid


artemoin C

An artemoin in which the two hydroxy groups on the C-30 side-chain are located at positions 15 and 16.


citrafungin B

A carboxylic ester obtained by the formal condensation of the 4-carboxy group of (2R)-2-hydroxy-2-{(3R,5R)-2-oxo-5-[(1E,5Z,8Z)-tetradeca-1,5,8-trien-1-yl]tetrahydrofuran-3-yl}butanedioic acid with the hydroxy group of 3-carboxy-2,3-dideoxy-L-threo-pentaric acid. It is a fungal metabolite that acts as an inhibitor of geranylgeranyltransferase type I(GGTase I) of pathogenic fungal species.


5-oxo-2,5-dihydro-2-furylacetic acid

A 5-oxo-2-furylacetic acid having the C=C double bond at the 3,4-position.


isopatulin

A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 4 an 6 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. Also known as neopatulin, it is a mycotoxic substance produced by Aspergillus and Penicillium species.


A member of the class of 2-benzofurans that is 1,3-dihydro-2-benzofuran substituted by oxo, methyl, hydroxy and hydroxy groups at positions 1,4,5, and 7, respectively. It is a natural product found in several genera of fungi including Eurotium repens.


A butan-4-olide having a 2-bromoethyl group at the 3-position and two methyl substituents at the 5-position.


A aldonolactone phosphate that is L-arabino-1,4-lactone carrying a single phospho substituent at position 5.


(S)-ofurace

A 2-chloro-N-(2,6-dimethylphenyl)-N-(2-oxotetrahydrofuran-3-yl)acetamide that is the S-enantiomer of ofurace.


DESOXYPODOPHYLLOTOXIN

A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group.


paraminabeolide F

A withanolide that is 18,22:23,26-diepoxyergosta-1,4-diene substituted by oxo groups at positions 3, 18 and 26. It has been isolated from a Formosan soft coral Paraminabea acronocephala.


A butan-4-olide carrying acyl and hydroxymethyl substituents at positions 3 and 4 respectively and having 3R,4R-configuration.


name: 3-furancarboxylic acid, tetrahydro-4-methylene-5-oxo-2-propyl-, (2r,3s)-rel-


A gamma-lactone that is 5-(hydroxymethyl)furan-2(5H)-one substituted at positions 3 and 4 by hydroxy groups (the 5S-stereoisomer).


A 5-oxo-2-furylacetic acid having a carboxy group at the 2-position.


CHAETOVIRIDIN I

An  azaphilone found in Chaetomium globosum.


The 2-chloro derivative of cis-4-carboxymethylenebut-2-en-1,4-olide.


plakortolide N

An organic heterobicyclic compound that is a cyclic peroxy compound isolated from the Australian marine sponge Plakinastrella clathrata.


name: 3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2R,3S)-rel-


TRILOBACIN

A polyketide isolated from the bark of Asimina triloba. It has been shown to exhibit  cytotoxicity in the NCI human tumor cell line screen.


A butan-4-olide that is gamma-butyrolactone with a 6-methylheptanoyl substituent at position 3 and a hydroxymethyl substituent at position 4 (the 3R,4R-stereoisomer).


PARAMINABEOLIDE C

A withanolide that is 23,26-epoxyergosta-1,4-diene substituted by an acetyloxy group at position 18, a hydroxy group at position 22 and oxo groups at positions 3 and 26.  Isolated from a Formosan soft coral Paraminabea acronocephala, it has been found to inhibit the accumulation of the pro-inflammatory iNOS protein.


A 1,3-oxazole compound having a phenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position.  It is a chemical allergen used for immunological experiments, particularly for experiments on delayed type hypersensitivity.


5-oxo-2-furylacetic acid

An oxo monocarboxylic acid that is 2,5-dihydrofuran-2-ylacetic acid substituted by an oxo group at position 5.


A butan-4-olide having a methylene group at the 3-position and two methyl substituents at the 5-position.


EUTYPOID E

A butenolide that is furan-2(5H)-one substituted by a 3,5-dihydroxyphenyl group at position 3 and a 3,4-dihydroxybenzyl group at position 4. It has been isolated from Penicillium species.


gamma-dodecalactone

A gamma-lactone that is oxolan-2-one substituted by an octyl group at position 5.


decatromicin A

A carbohydrate-containing antibiotic isolated from Actinomadura sp. MK73-NF4. It specifically inhibits the growth of gram-positive bacteria including multi-drug resistant strains such as Staphylococcus aureus MS9610 and menthicilin-resistant S.aureus (MRSA).


A aldonolactone phosphate that is D-xylono-1,4-lactone carrying a single phospho substituent at position 5.


citrafungin A

A carboxylic ester obtained by the formal condensation of 4-carboxy group of (2R)-2-hydroxy-2-{(3R,5R)-2-oxo-5-[(1E,5Z)-tetradeca-1,5-dien-1-yl]tetrahydrofuran-3-yl}butanedioic acid with the hydroxy group of 3-carboxy-2,3-dideoxy-L-threo-pentaric acid. It is a fungal metabolite that acts as an inhibitor of geranylgeranyltransferase type I(GGTase I) of pathogenic fungal species.


An isobenzofuranone that is thunberginol F attached to a beta-D-glucopyranosyl group at position 4 via a glycosidic linkage. It has been isolated from the roots of Scorzonera judaica .


auricin

An angucycline-like polyketide discovered in Streptomyces aureofaciens that is only stable at acidic pH.


paraminabeolide E

A withanolide that is the C-25 epimer of paraminabeolide D. It has been isolated from a Formosan soft coral Paraminabea acronocephala.


A 1,3-oxazole compound having a 2-furyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position.


A lignan isolated from the leaves Piper sanguineispicum.


The trans-isomer of 2-chloro-4-carboxymethylenebut-2-en-1,4-olide.


N-acyl-L-homoserine lactone

An N-acyl homoserine lactone that has L configuration.


seco-plakortolide O

A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 4, a 2-hydroxy-2-methyl-14-phenyltetradeca-11,13-dien-1-yl group at position 5 and a methyl group at position 5 (the 4R,5R stereoisomer). It is isolated from the Australian marine sponge Plakinastrella clathrata.


A 5-oxo-2-furylacetic acid having a 4-methyl substituent.


The (S)-enantiomer of 5-oxo-2,5-dihydro-2-furylacetic acid.


MONODICTYOCHROMONE B

A  chromanone isolated from the marine derived fungus Monodictys putredinis and exhibits inhibitory activity against P450.


GIGANTRIONENIN

A member of the class of oxolanes that is tetrahydrofuran substituted by a 7-[5-methyl-2-oxo-2,5-dihydrofuran-3-yl]heptyl at position 2 and a 1,4,5-trihydroxyhenicos-8-en-1-yl group at position 5. Isolated from Goniothalamus giganteus, it exhibits cytotoxic activity.


N-dodecanoyl-L-homoserine lactone

An N-acyl-L-homoserine lactone having dodecanoyl as the acyl substituent.


ELAEODENDROSIDE B

A steroid lactone isolated from Elaeodendron tangenala and Elaeodendron glaucum and exhibits antiproliferative activity against A2780 human ovarian cancer cells.


seco-plakortolide P

A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 4, a 2-hydroxy-2-methyl-14-phenyltetradeca-11,13-dien-1-yl group at position 5 and a methyl group at position 5 (the 4S,5S stereoisomer). It is isolated from the Australian marine sponge Plakinastrella clathrata.


HINOKININ

A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 3,4-methylenedioxybenzyl group at positions 3 and 4 (the 3R,4R-diastereoisomer).


A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a 3,4-dihydroxybenzylidene group at position 3 and a 3,4-dihydroxyphenyl group at position 5. It has been isolated from the roots of Scorzonera judaica.


name: 4-Hydroxy-4-methyl-5-hexenoic acid gamma lactone


dihydroanhydropodorhizol

A member of the class of butan-4-olides carrying 3,4,5-trimethoxybenzyl and (1,3-benzodioxol-5-yl)methyl substituents at positions 3 and 4 respectively.


The (R)-enantiomer of 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoic acid.


An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 5-oxo-furan-2-acetic acid.


An organochlorine compound that is 2,5-dihydro-2-furylacetic acid substituted by chloro groups at positions 2 and 4 and an oxo group at position 5.


Z-butylidenephthalide

A  gamma-lactone that is  phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits  hypoglycemic activity.


A 1,3-oxazole compound having a beta-styryl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position.


phloxine O

A xanthene dye that is  fluorescein in which the hydrogens at positions 2',4',5' and 7' are replaced by bromo groups, and the hydrogens at positions 4,5,6 and 7 are replaced by chloro groups. It is a red synthetic pigment which is widely used in colored cosmetics (e.g. lipsticks and blushers).


(E)-ascladiol

A butenolide that is furan-2(5H)-one which is substituted by a hydroxymethyl group at position 4 and a 2-hydroxyethylidene group at position 5 (the 5E isomer). A direct precursor of patulin in cell-free preparations of Penicillium urticae patulin-minus mutants J1 and S11, but not S15.


An organosulfonic acid that consists of 5-oxo-2-furylacetic acid bearing a sulfo group at position 2.


carlosic acid methyl ester

The methyl ester of carlosic acid.


plakortolide M

An organic heterobicyclic compound that is a cyclic peroxy compound isolated from the Australian marine sponge Plakinastrella clathrata.


gamma-decalactone

A gamma-lactone that is oxolan-2-one substituted by a hexyl group at position 5.


A 2-oxo monocarboxylic acid that is pyruvic acid substituted at position 3 by a 5-oxofuran-2-ylidene group.


5-oxo-4,5-dihydro-2-furylacetic acid

The 4,5-dihydro- derivative of 5-oxo-2-furylacetic acid.


decatromicin B

A carbohydrate-containing antibiotic isolated from Actinomadura sp. MK73-NF4. It specifically inhibits the growth of gram-positive bacteria including multi-drug resistant strains such as Staphylococcus aureus MS9610 and menthicilin-resistant S.aureus (MRSA).


A 5-oxo-2-furylacetic acid that is muconolactone substituted at position 5 by a chloro group.


isoaigialone B

A gamma-lactone that is 3,4,5,7-tetrahydro-2H-furo[3,4-b]pyran substituted by heptyl, methyl, hydroxy, hydroxy, oxo and methyl groups at positions 2R, 3S, 3S, 4R, 5 and 7R, respectively. It is isolated from the endophytic fungus Phaeoacremonium sp. and exhibits antifungal activities.


vitamin C

Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.


gallein

A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.


A five-membered form of ribonolactone having D-configuration.


ofurace

A racemate comprising equal amounts of (R)- and (S)-ofurace.


MONODICTYOCHROMONE A

A chromanone isolated from the marine derived fungus Monodictys putredinis and exhibits inhibitory activity against P450.


MICROPERFURANONE

A butenolide that is furan-2(5H)-one which is substituted by a phenyl group at position 3, a benzyl group at position 4, and a hydroxy group at position 5 (the (-)-enantiomer). A secondary metabolite obtained from Aspergillus nidulans.


ELAEODENDROSIDE F

A steroid lactone isolated from Elaeodendron tangenala and Elaeodendron glaucum and exhibits antiproliferative activity against A2780 human ovarian cancer cells.


ISOASPULVINONE E

A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts an E-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity.


A butan-4-olide that is gamma-butanolactone substituted by a 1-hydroxyethyl group at position 4.


5-oxotetrahydrofuran-2-carboxylic acid

A gamma-lactone resulting from the formal intramolecular condensation of the alcoholic hydroxy group of 2-hydroxyglutaric acid with the carboxy group at position 5.


A member of the class of butenolides that is furan-2(5H)-one substituted by 4-hydroxyphenyl, hydroxy and 4-hydroxybenzylidene groups at positions 3, 4 and 5, respectively.


tulipalin B

A member of the class of butan-4-olides that is 3-methylidenebutan-4-olide carrying an additional hydroxy substituent at position 4 (the 4R-enantiomer)


A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.


A butenolide that is (5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate carrying an additional 6-methylheptanoyl substituent at position 4.


A butan-4-olide that is 5-(3'-hydroxyphenyl)-gamma-valerolactone in which the phenolic hydrogen has been replaced by a beta-D-glucuronyl residue


hydramacrophyllol B

An isobenzofuranone that is 2-benzofuran-1(3H)-one substituted by a hydroxy group at position 7 and a (R)-hydroxy(4-hydroxyphenyl)methyl group at position 3. It has been isolated from the roots of Scorzonera judaica.


A butenolide having a carboxymethylene group at the 4-position.


sarmentologenin

A steroid lactone that is card-20(22)-enolide substituted by hydroxy groups at positions 3, 5, 11, 14 and 19.


Any gamma-lactone having the lactone moiety derived from 4-hydroxybutanoic acid.


artemoin

A family of gamma-lactones that are isolated from the seeds of Annona atemoya.


A butenolide that is furan-2(3H)-one substituted by a 3,4-dihydroxybenzylidene group at position 3 and a 3,4-dihydroxyphenyl group at position 5 (the 3E stereoisomer). It is isolated from the fermentation broth of the fungal strain Rhizoctonia solani F23372 and has been found to possess significant tyrosine kinase inhibitory potential. It also inhibits the growth of A431 human epidermoid carcinoma and MKN-7 human stomach cancer cell lines.


A 1,3-oxazolone derivative having a nitrophenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position.


(-)-pluviatolide

A butan-4-olide that is dihydrofuran-2(3H)-one which is substituted by a vanillyl group at position 3 and by a 3,4-methylenedioxybenzyl group at position 4 (the R,R stereoisomer).


Major microspecies at pH 7.3.


A 1,3-oxazole having benzyl, hydroxymethylene and oxo groups at positions 2, 4 and 5 respectively.


plakortolide K

An organic heterobicyclic compound that is a cyclic peroxy compound isolated from the Australian marine sponge Plakinastrella clathrata.


A butenolide that is furan-2(5H)-one substituted by a hydroxymethyl group at position 3 and a methyl group at position 4. Isolated from an edible mushroom  Mycoleptodonoides aitchisonii, it exhibits protective activity against endoplasmic reticulum (ER) stress dependent cell death.


An N-acyl-D-homoserine lactone having 3-oxododecanoyl as the acyl substituent.


A butenolide that is 3,4-dihydroxyoxolan-2-one carrying an additional 2-hydroxyethanimidoyl substituent at position 5.


An organonitrogen heterocyclic compound that is a 21-membered macrocyclic lactam, substituted by a ({1-[(cyclohex-1-en-1-ylcarbonyl)amino]cyclopropyl}carbonyl)oxy group at position 17, which is obtained from Streptomyces sp. TC-1190. It exhibits growth inhibitory effects on a series of human tumour cell lines.


Colorectal Cancer cM1a TNM Finding v7

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Colorectal cancer with metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node). (from AJCC 7th Ed.)


A 3-enoyl-CoA in which the beta C=C double bond has cis stereochemistry.


A fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (Z)-hex-3-enoic acid.


A 4,5-dihydrocortisone that has beta- configuration at position 5.


A ribonucleic acid that is ribosomal RNA (rRNA) in which one of the RNA bases is N(3)-methylpseudouridine.


name: N-[2-[(3-chloroanilino)-oxomethoxy]ethyl]carbamic acid propan-2-yl ester


A  monosaccharide derivative that is the 7-O-glucuronide of dihydroresveratrol .


A member of the class of aflatoxins that is 8,9-dihydro-9-hydroxyaflatoxin B1 having an S-glutathionyl moiety attached at position 8.


A muconic semialdehyde that is 6-oxohexa-2,4-dienoic acid which is substituted by a hydroxy group at position 2 and a methyl group at position 5 (the 2Z,4E isomer).


nicotinic acid D-ribonucleotide

A D-ribonucleotide having nicotinic acid as the nucleobase.


TRIPROLIDINE HYDROCHLORIDE

A hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. Its monohydrate is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.


L-vinylglycine

A non-proteinogenic L-alpha-amino acid with a structure in which a vinyl group is bonded to the alpha-carbon of glycine.


A cyclohexadienecarboxylic acid that is cyclohexa-2,4-dienecarboxylic acid which is substituted at positions 1 and 6 by hydroxy groups which are both on the same side of the plane of the cyclohexadiene ring.


The (1R,6S)-diastereomer of 1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylic acid.


A 2-oxo monocarboxylic acid that is 2-oxopentanoic acid in which C-3 is methyl-substituted and C-5 is substituted by a carbamimidamido group.


Giant Cell-Rich Osteosarcoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An exceedingly rare, high-grade variant of conventional osteosarcoma characterized by the presence of numerous osteoclast-like giant cells and variable amount of tumor osteoid.


A member of the class of quinazolines that is quinazoline which is substituted by a benzylnitrilo group at position 4.


Halogenated cyanine compound that binds nucleic acids.


A 2-demethylmenaquinol whose structure comprises a benzohydroquinone nucleus and a side chain of twelve isoprenoid units.


A nucleoside 3',5'-cyclic phosphorothioate having 8-bromo-7-deazaadenine as the nucleobase (the Sp-stereoisomer).


An imidazopyridine that is 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine in which the amino hydrogen is replaced by a 5-chloro-1H-pyrrolo[2,3-d]pyrimidin-4-yl group. A potent inhibitor of AKT1 kinase.


A pyrrolopyrimidine that is 7-deazaguanine bearing an aminomethyl substituent at the 7 position.


TOYOCAMYCIN

An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.


An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydroxy group at position 2 of the ribose moiety has been replaced by a hydrogen.


sangivamycic acid

An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a carboxy group.


A nucleoside 3',5'-cyclic phosphorothioate having 8-bromo-7-deazaadenine as the nucleobase (the Rp-stereoisomer).


A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 by a methyl[(3R,4R)-4-methyl-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]nitrilo group. It is a potent JAK3-selective chemical probe.


A pyrrolopyrimidine that is 7-deazaguanine bearing a carboxylic acid substituent at the 7 position.


A nucleoside 3',5'-cyclic phosphorothioate having 7-bromo-7-deazaadenine as the nucleobase (the Sp-stereoisomer).


epoxyqueuine

An epoxide obtained by formal epoxidation of the double bond in the cyclohexene moiety of queuine.


mirodenafil

A member of the class of pyrrolopyrimidines that is 3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one having a 5-{[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl}-2-propoxyphenyl group at positon 2, ethyl group at position 5, and a propyl group at position 7. It is a phosphodiesterase type 5 inhibitor which is used for the treatment of erectile dysfunction.


Lck inhibitor

A member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively).


A pyrrolopyrimidine that is 7-deazaguanine substituted at position 7 by a cyano group.


tubercidin

An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.


ritlecitinib

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 by a [(3R,6S)-6-methyl-1-(prop-2-enoyl)piperidin-3-yl]amino group. It is a dual inhibitor of Janus kinase 3 and the TEC family of tyrosine kinases.


A member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by (1-phenylethyl)amino and 4-[(4-ethylpiperazin-1-yl)methyl]phenyl groups at positions 4 and 6, respectively.


A pyrrolopyrimidine that is 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor.


delgocitinib

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a (3S,4R)-1-(cyanoacetyl)-3-methyl-1,6-diazaspiro[3.4]octan-6-yl group at position 4. It is a pan-Janus kinase (JAK) inhibitor and is approved for treatment of atopic dermatitis (AD) in Japan.


A nucleoside 3',5'-cyclic phosphorothioate having 7-deazaadenine as the nucleobase (the Rp-stereoisomer).


eritrityl tetranitrate

Erythritol in which each of the hydroxy groups has been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to nitroglycerin. It is usually used diluted with lactose or other suitable inert excipients, in order to minimise the risk of explosion; undiluted erythrityl tetranitrate can be exploded by percussion or excessive heat.


name: Stage IIIB Anal Canal Cancer AJCC v6 and v7

description: Stage IIIB includes: (T4, N1, M0); (Any T, N2, M0); (Any T, N3, M0). T4: Tumor of any size that invades adjacent organ(s).  N1: Metastasis in perirectal lymph node(s).  N2: Metastasis in unilateral internal iliac and/or inguinal lymph node(s).  N3: Metastasis in perirectal and inguinal lymph nodes and/or bilateral internal iliac and/or inguinal lymph nodes. M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Stage III Anal Canal Cancer AJCC v6 and v7

description: Stage III includes: IIIA (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); IIIB (T4, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  T1: Tumor 2 cm or less in greatest dimension.  T2: tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension.  T4: Tumor of any size that invades adjacent organ(s).  N1: Metastasis in perirectal lymph node(s).  N2: Metastasis in unilateral internal iliac and/or inguinal lymph node(s).  N3: Metastasis in perirectal and inguinal lymph nodes and/or bilateral internal iliac and/or inguinal lymph nodes. M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


name: Stage IIIA Anal Canal Cancer AJCC v6 and v7

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension.  T4: Tumor of any size that invades adjacent organ(s).  N1: Metastasis in perirectal lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


A C21-steroid that is cortisone in which the 21-hydroxy group has been oxidised to the corresponding aldehyde.


A C21-steroid that is progesterone carrying two additional oxo substituents at positions 11 and 21


A C21-steroid that is cortisol in which the 21-hydroxy group has been oxidised to the corresponding aldehyde.


ERIBULIN MESYLATE

A methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage.


Liver Cancer pN1 TNM Finding v6

description: Liver cancer with regional lymph node metastasis. (from AJCC 6th Ed.)


name: Liver Cancer Pathologic Regional Lymph Nodes TNM Finding v6

description: A pathologic finding about one or more characteristics of liver cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of regional lymph nodes. TNM pathologic regional lymph nodes findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery.


Liver Cancer pN0 TNM Finding v6

description: Liver cancer with no regional lymph node metastasis. (from AJCC 6th Ed.)


name: YAP1 and ZFTA Gene Rearrangements Status Unknown

description: A finding indicating that there is no information regarding the presence or absence of YAP1 and ZFTA gene rearrangements in a tumor sample.


Pancreatic Infection

description: An infectious process affecting the pancreas.


Intramucosal Adenocarcinoma

description: A neoplastic lesion that shows morphologic evidence of invasion into the lamina propria or muscularis mucosa.  There is no evidence of invasion into the submucosa.  Evidence of invasion may refer to stromal invasion by single cells or clusters of cells, presence of atypical and complex glandular architectural patterns beyond those that are present in normal mucosa, desmoplasia, and/or vascular invasion.


Gastric Intramucosal Adenocarcinoma

description: A neoplasm that arises from the gastric glandular epithelium and invades the lamina propria but not the submucosa.  There is marked glandular crowding, branching and budding, intraluminal necrosis, and prominent mitotic activity.  Desmoplastic changes may be present or absent.


Esophageal Intramucosal Adenocarcinoma

description: Adenocarcinoma that arises from the esophagus and is confined entirely to the mucosa.


MEPERIDINE HYDROCHLORIDE

The hydrochloride salt of pethidine. An analgesic used for the treatment of postoperative and labour pain.


A long-chain primary fatty alcohol that is hexadecanol containing a double bond at unspecified position.


Thrombophilia Related to COVID-19

description: Thrombophilia in a patient with probable or confirmed acute COVID-19.


name: Reactive B-Cell Rich Lymphoid Proliferations that Can Mimic Lymphoma

description: A term that refers to non-neoplastic, dense B-cell lymphoproliferations in nodal or extranodal sites that resemble B-cell lymphoma.


SONIDEGIB PHOSPHATE

A phosphate salt obtained by reaction sonidegib with two equivalent of phosphoric acid. Used for treatment of locally advanced basal cell carcinoma.


Unbearable Pain

description: A sensation of extreme discomfort and anguish that is overwhelming and unendurable.


name: Atherosclerosis of Other Type of Bypass Graft(s) of the Extremities with Rest Pain, Other Extremity

description: Evidence of atherosclerosis of other type of bypass graft(s) of the extremities with rest pain in the other extremity.


name: Gastric Cancer pTis TNM Finding v6 and v7

description: Gastric cancer in situ with cancer cells confined within the glandular basement membrane (intraepithelial) and without invasion into the lamina propria. (from AJCC 6th and 7th Eds.)


An acyl-CoA resulting from the formal condensation of the thiol group of coenzyme A with the carboxy group of ascr#10.


(S)-sertaconazole nitrate

An organic nitrate salt obtained by reaction of equimolar amounts of (S)-sertaconazole and nitric acid.


maradolipid

A polyacyl alpha,alpha-trehalose in which the two hydroxy hydrogens at positions 6 and 6' of alpha,alpha-trehalose have been replaced by fatty acyl groups. A 6,6'-diacyltrehalose lipid found in C. elegans dauer larvae.


A disaccharide that is D-glycopyranose in which the hydroxy group at position 3 has been converted into the corresponding alpha-L-fucoside.


An alpha-L-Fucp-(1->3)-Glcp in which the carbon bearing the anomeric hydroxy group has alpha configuration.


NICOTINALDEHYDE

A pyridinecarbaldehyde that is pyridine substituted by a formyl group at position 3.


A pyridinecarbaldehyde that is pyridine in which the hydrogen at position 2 is replaced by a formyl group.


pyridoxal

A pyridinecarbaldehyde that is pyridine-4-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 5 respectively. The 4-carboxyaldehyde form of vitamin B6, it is converted into pyridoxal phosphate, a coenzyme for the synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.


A pyridinemonocarboxylic acid that is pyridine-4-carboxylic acid substituted by a methyl group, hydroxy group and formyl group at positions 2,3 and 5, respectively.


isopyridoxal

A pyridinecarbaldehyde that is pyridine-5-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 4 respectively.


pyridoxal 5-phosphate

The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.


A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of 11a-hydroxyiodtetracycline; major species at pH 7.3.


SAMPANGINE

A copyrine alkaloid with formula C15H8N2O, extracted from several plants including the stem bark of Cananga odorata. It is a heme biosynthesis inhibitor and exhibits antifungal and anticancer properties.


4-amino-4-deoxychorismic acid

A dicarboxylic acid comprising chorismic acid having its 4-hydroxy group replaced by an amino group.


1-O-glyceryl beta-D-galactopyranoside

A 3-D-galactosyl glycerol in which the carbon bearing the anomeric hydrogen has beta configuration.


A glycophytoceramide having a 4-O-(cyclopropylmethyl)-alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen. One of a series of an extensive set of 4"-O-alkylated alpha-GalCer analogues evaluated (PMID:30556652) as invariant natural killer T-cell (iNKT) antigens.


name: Opioid Use, Unspecified with Opioid-Induced Psychotic Disorder with Hallucinations

description: Evidence of opioid use, unspecified with opioid-induced psychotic disorder with hallucinations.


A pyrrolopyrazine that is pyrrolo[1,2-a]pyrazine in which the hydrogen at position 3 is replaced by a methyl group.


ganglioside GM2 (18:0)

A  sialotriaosylceramide that is N-acetyl-beta-D-galactosaminyl-(1->4)-alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine in which the acyl group on the sphingosine nitrogen is octadecanoyl. A constituent of natural ganglioside GM2.


A sialotriaosylceramide consisting of the tetrasaccharide beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc attached to the primary hydroxy function of ceramide.


Grade 5 Serum Sickness, CTCAE

description: Death


ketoestrane

Any oxo steroid (or derivative) based on an estrane skeleton.


name: Neoplasm of uncertain or unknown behavior of craniopharyngeal duct

description: Evidence of neoplasm of uncertain behavior of craniopharyngeal duct.


name: Connective and Soft Tissue Neoplasm (Antiquated)


Periosteal fibrosarcoma

description: A malignant fibroblastic tumor arising from the periosteal connective tissue that surrounds a bone.


description: A rare malignant tumor of soft tissue characterized by a bimorphic pattern composed of undifferentiated small round cells and islands of well differentiated hyaline cartilage.


name: Very Low Risk Esophageal Gastrointestinal Stromal Tumor


name: Storiform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade 3


Extraskeletal Osteoma

description: A rare benign overgrowth of bone arising from extraskeletal sites.


Angiosarcoma NCI Grade 2

description: An angiosarcoma with less than 15% necrosis.


Benign stromal tumor

description: A benign neoplasm composed of mesenchymal stromal cells without evidence of cellular atypia.


Advanced Round Cell Liposarcoma

description: A round cell liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Non-Cutaneous Leiomyosarcoma

description: A leiomyosarcoma arising from an anatomic site other than skin.


Hemangiopericytoma of orbit

description: A benign or malignant hemangiopericytoma arising from the orbit.


Malignant hemangiopericytoma metastatic

description: A malignant hemangiopericytoma which has spread to another anatomical site.


name: Very Low Risk Gastric Gastrointestinal Stromal Tumor


name: Very Low Risk Small Intestinal Gastrointestinal Stromal Tumor


Kaposi Sarcoma NCI Grade 2

description: A Kaposi sarcoma with less than 15% necrosis.


name: Inflammatory Malignant Fibrous Histiocytoma NCI Grade 3


name: High Risk Small Intestinal Gastrointestinal Stromal Tumor


Malignant hemangiopericytoma of orbit

description: A malignant hemangiopericytoma arising in the orbit.


Malignant hemangiopericytoma of skin

description: A malignant hemangiopericytoma arising in the skin.


name: Very Low Risk Gastrointestinal Stromal Tumor


name: High Risk Esophageal Gastrointestinal Stromal Tumor


Epithelioid Sarcoma NCI Grade 2

description: An epithelioid sarcoma with less than 15% necrosis.


name: Very Low Risk Colorectal Gastrointestinal Stromal Tumor


name: Intermediate Risk Gastric Gastrointestinal Stromal Tumor


Angiomyosarcoma

description: A malignant smooth muscle neoplasm characterized by the presence of atypical spindle cells and formation of vascular channels.


Benign Orbit Hemangiopericytoma

description: A benign hemangiopericytoma arising from the orbit.


Leiomyosarcoma NCI Grade 2

description: A leiomyosarcoma with less than 15% necrosis.


name: High Risk Gastrointestinal Stromal Tumor


Unresectable Round Cell Liposarcoma

description: A round cell liposarcoma that is not amenable to surgical resection.


name: High Risk Gastric Gastrointestinal Stromal Tumor


Sarcoma NCI Grade 2

description: A sarcoma with less than 15% necrosis.


name: Intermediate Risk Small Intestinal Gastrointestinal Stromal Tumor


Malignant hemangiopericytoma recurrent

description: A rare malignant mesenchymal neoplasm, believed to have its origin in smooth muscle derived pericytes, which has recurred after treatment.


Giant cell sarcoma

description: A sarcoma characterized by the presence of large, anaplastic malignant cells.


name: High Risk Colorectal Gastrointestinal Stromal Tumor


name: Malignant Hemangiopericytoma NCI Grade 2


Mixed osteosarcoma

description: A term referring to conventional osteosarcomas which do not have a dominant matrix pattern and contain a mixture of osteoid matrix in combination with chondroid matrix and/or collagen fibers.


Lipomatous hemangiopericytoma

description: A benign hemangiopericytoma with lipomatous differentiation.


name: Solitary fibrous tumor and hemangiopericytoma grade 1

description: A hemangiopericytoma without malignant morphologic or clinical characteristics.


Metastatic Round Cell Liposarcoma

description: Round cell liposarcoma that has spread to other anatomic sites.


description: A rare malignant mesenchymal neoplasm that is believed to have its origin in smooth muscle derived pericytes without evidence of metastases.


name: Intermediate Risk Gastrointestinal Stromal Tumor


name: Storiform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade 2


name: Intermediate Risk Esophageal Gastrointestinal Stromal Tumor


Benign Mediastinal Hemangiopericytoma

description: A benign hemangiopericytoma arising from the mediastinum.


Benign Kidney Hemangiopericytoma

description: A benign hemangiopericytoma arising from the kidney.


Refractory Round Cell Liposarcoma

description: Round cell liposarcoma that does not respond to treatment.


description: A morphologic variant of dermatofibrosarcoma protuberans characterized by the presence of spindle-shaped fibroblastic cells, histiocytic cells, and a storiform growth pattern.


name: Well Differentiated Malignant Hemangiopericytoma

description: A malignant hemangiopericytoma with well-differentiated morphological features.


name: Malignant Hemangiopericytoma NCI Grade 3


name: Intermediate Risk Colorectal Gastrointestinal Stromal Tumor


A primary nitroalkane that is 2-methylbutane substituted by a nitro group at position 4. It is a herbivore-induced plant volatile found in the leaves of Oenothera biennis.


(3S,4S)-3-hydroxy-4-methyloctanoic acid

A hydroxy fatty acid that is caprylic (octanoic) acid substituted at positions 3 and 4 by hydroxy and methyl grous respectively.


lyxonic acid

A pentonic acid resulting from the formal oxidation of the aldehyde group of lyxose to the corresponding carboxylic acid.


L-lyxonic acid

A lyxonic acid that has L-configuration.


D-lyxonic acid

A lyxonic acid that has D-configuration.


Colorectal Cancer pM1b TNM Finding v7

description: Colorectal cancer with metastases in more than one organ/site or the peritoneum. (from AJCC 7th Ed.)


methyl beta-(acetylthio)isobutyrate

A methyl ester derived from beta-(acetylthio)isobutyric acid.


name: 4-[4-[3-(2-furanyl)prop-2-enylidene]-3-methyl-5-oxo-1-pyrazolyl]benzoic acid propan-2-yl ester


pentofuranose

The furanose form of any pentose.


Congenital Ventricular Tachycardia

description: An electrocardiographic finding of a tachycardia that originates in the ventricles that is present at birth.


L-leucine 4-methoxy-2-naphthylamide

An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of L-leucine with the amino group of 4-methoxy-2-naphthylamine.


Grade 3 Delayed Puberty, CTCAE

description: No breast development by age 14 yrs for females; no increase in testes volume or no Tanner Stage 2 by age 16 yrs for males; hormone replacement indicated


Delayed Puberty, CTCAE

description: A disorder characterized by unusually late sexual maturity.


Grade 2 Delayed Puberty, CTCAE

description: No breast development by age 13 yrs for females; testes volume of <3 cc or no Tanner Stage 2 development by age 14.5 yrs for males


name: Skene Gland Adenocarcinoma of the Urethra

description: A rare urethral adenocarcinoma arising from the Skene gland. It is characterized by morphological and immunohistochemical features similar to prostate adenocarcinoma.


11-sulfooxy-9,10-dihydrojasmonic acid

A dihydrojasmonic acid that is 9,10-dihydrojasmonic acid in which one of the methylene hydrogens at position 11 has been replaced by a sulfooxy group.


Refractory Anaplastic Ependymoma

description: Anaplastic ependymoma that is resistant to treatment.


An eight-membered homodetic cyclic peptide comprising the sequence L-leucine, L-serine, L-alpha-glutamic acid, L-threonine, L-tyrosine, L-threonine, L-lysine, D-leucine.


quercetin O-glucoside

A quercetin O-glycoside that is an O-glucosylated derivative of quercetin.


quercetin 3,4'-di-O-beta-D-glucoside

A quercetin O-glucoside that is quercetin with two beta-D-glucosyl residues attached at positions 3 and 4'.


CALABRICOSIDE A

A quercetin O-glucoside in which a alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl and a beta-D-glucopyranosyl residue is attached respectively via a glycosidic linkage at positions 3 and 7 of quercetin. It is isolated from the aerial parts of  Putoria calabrica and exhibits radical scavenging activity.


quercetin 7,4'-di-O-beta-D-glucoside

A quercetin O-glucoside that is quercetin with two beta-D-glucosyl residues attached at positions 7 and 4'.


A quercetin O-glucoside that is quercetin substituted by a alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranosyl] residue at position 3 via a glycosidic linkage. Isolated from Ginkgo biloba, it exhibits antioxidant activity.


quercetin 3,7-di-O-beta-D-glucoside

A quercetin O-glucoside that is quercetin with two beta-D-glucosyl residues attached at positions 3 and 7.


quercetin 3-O-rhamnoside-7-O-glucoside

A quercetin O-glucoside that is quercetin 7-O-beta-D-glucoside carrying an additional alpha-L-rhamnosyl residue at position 3.


CALABRICOSIDE B

A quercetin O-glucoside in which a 4''-O-caffeoyl-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl and a beta-D-glucopyranosyl moiety is attached respectively via a glycosidic linkage to positions 3 and 7 of quercetin. It is isolated from the aerial parts of Putoria calabrica and exhibits radical scavenging activity.


A quercetin O-glucoside that is quercetin attached to a beta-D-sambubiosyl residue at position 3 via a glycosidc linkage.


camellianoside

A quercetin O-glucoside consisting of quercetin having a beta-D-xylopyranosyl-(1->3)-6-deoxy-alpha-L-mannopyranosyl-(1->6)-beta-D-glucopyranosyl residue at position 3. It is isolated from the leaves of Camellia japonica and exhibits antioxidant activity.


quercetin 3-O-gentiotetroside

A quercetin O-glucoside that is quercetin attached to a beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside residue at position 3 via a glycosidic linkage.


A quercetin O-glucoside that is quercetin attached to a beta-D-sophorotriosyl residue at position 3 via a glycosidic linkage.


ISOQUERCETIN

A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells


A quercetin O-glucoside that consists of quercetin attached to a beta-D-glucopyranosyl moiety at position 7 and a alpha-L-6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranosyl residue at position 3 via a glycosidic linkage. Isolated from the leaves of Ginkgo biloba, it exhibits antioxidant activity.


petiolaroside decaacetate

A quercetin O-glucoside that is the decaacetate ester derivative of  petiolaroside. Isolated from the aerial parts of Delphinium staphisagria, it exhibits trypanocidal activity.


TRANSILIN

A quercetin O-glucoside that is 3-O-methylquercetin attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It has been isolated from Ophioglossum pedunculosum and Lepisorus contortus.


A quercetin O-glucoside that is the 2''-acetyl derivative of petiolaroside. Isolated from the aerial parts of   Delphinium staphisagria, it exhibits trypanocidal activity.


QUERCIMERITRIN

A quercetin O-glucoside in which a glucosyl residue is attached at position 7 of quercetin via a beta-glycosidic linkage.


A quercetin O-glucoside that is  quercetin attached to a 6-O-malonyl-beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage.


Exposure to radiation

description: Exposure to radioactive materials or ionizing radiation, whether by external irradiation, contact or contamination with radioactive material, or incorporation of radioactive materials, as in the case of certain diagnostic procedures.


UV Radiation Exposure

description: The exposure to uv radiation via incident light from the sun.


Unintended Radiation Exposure

description: The unintentional exposure to radiation of a person.


name: Psoralen and Ultraviolet A (PUVA) Therapy Exposure

description: A finding indicating that a patient has been exposed to psoralen and ultraviolet A (PUVA) therapy for a benign or malignant condition.


Eyelid Carcinoma cNX TNM Finding v8

description: Eyelid carcinoma in which the regional lymph nodes cannot be assessed. (from AJCC 8th Ed.)


Unresectable Vaginal Carcinoma

description: Vaginal carcinoma that is not amenable to surgical resection.


N-arachidonoyl-L-leucine

An L-leucine derivative resulting from the formal condensation of the carboxy group of arachidonic acid with the amino group of L-leucine.


Cytomegalovirus hepatitis

description: Hepatitis secondary to viral infection with cytomegalovirus.


name: Non-Neoplastic Liver and Intrahepatic Bile Duct Disorder

description: A non-neoplastic disorder that affects the liver parenchyma and the intrahepatic bile ducts. Representative examples include hepatitis, cirrhosis, and cholangitis.


Secondary Biliary Cholangitis

description: Biliary cirrhosis due to obstruction of the extrahepatic ducts.


Post-Hepatitis Chronic Hepatopathy

description: Chronic liver disease that occurs secondary to, and after recovery from, hepatitis.


Severe Liver Disease

description: Cirrhosis and portal hypertension with variceal bleeding, ascites, chronic jaundice, or status post liver transplantation.


Mitochondrial hepatopathy

description: A liver disorder caused by primary or secondary defects in the function of the mitochondria in the hepatocytes.


Focal nodular hyperplasia of liver

description: A non-neoplastic, regenerating hepatocellular hyperplasia, secondary to the presence of focal vascular abnormalities in the liver.


Hepatitis toxoplasmal

description: Hepatitis caused by infection with the protozoan parasite, Toxoplasma gondii.


Mild Liver Disease

description: Chronic hepatitis or cirrhosis without portal hypertension.


name: Cirrhosis of the Liver Secondary to Hepatitis B

description: Cirrhosis of the liver that develops as a sequelae of a hepatitis b infection.


Viral hepatitis, type G

description: A form of liver inflammation caused by the hepatitis G virus.


Central hemorrhagic necrosis of liver

description: A disorder in which damaged or dying hepatocytes severely impair venous outflow leading to sinusoidal dilatation and hemorrhage.


Chronic liver disease

description: Hepatic necrosis, inflammation, or scarring due to any cause that persists for more than 6 months. Manifestations may include signs and symptoms of cholestasis, portal hypertension, and/or abnormal liver function tests.


Congestive hepatopathy

description: Chronic passive congestion of the liver secondary to right heart failure. Elevation of central venous pressure leads to restriction of the hepatic circulation. Prolonged hepatic venous pressure may lead to liver fibrosis and cirrhosis.


Hepatic sclerosis

description: A thickening of the liver parenchyma. Hepatic sclerosis, fibrosis and cirrhosis may exist along a continuum.


Acute Hepatitis E Infection

description: A new infection by the hepatitis E virus, which is usually spread by the fecal-oral route. Signs and symptoms may include fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, jaundice, dark urine, clay-colored stools and joint pain. There is no specific anti-viral treatment, the infection resolves on its own.


Liver calculus

description: The presence of solitary or multiple stones in the intrahepatic bile ducts.


Moderate Liver Disease

description: Cirrhosis with portal hypertension but without any history of variceal bleeding.


name: Liver Disease Associated with Cystic Fibrosis

description: A spectrum of liver disorders that develop in patients with cystic fibrosis. It includes asymptomatic elevation of the liver function tests, steatosis, cholecystitis with cholelithiasis, sclerosing cholangitis, biliary cirrhosis, and cholangiocarcinoma.


Chronic viral hepatitis

description: Chronic hepatitis caused by viruses, most commonly hepatitis viruses B and C.


Alcoholic Cirrhosis with Ascites

description: A disorder of the liver secondary to the excessive consumption of ethanol that is characterized by the replacement of healthy tissue with fibrotic scar tissue and the accumulation of fluid in the peritoneal cavity.


Ductal plate malformation

description: A congenital disorder of the intrahepatic bile ducts characterized by abnormal embryonal development of the ductal plates.


Hepatic Infection

description: An acute or chronic infectious process affecting the liver.


An anthocyanin cation that is cyanidin in which the hydroxyl hydrogens at positions 3 and 5 are replaced by rutinosyl and glucosyl residues respectively.


Liver Cancer cM0 TNM Finding v7

description: Liver cancer without evidence of distant metastasis. (from AJCC 7th Ed.)


name: Grade 1 Immune System Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Immune System Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


name: Grade 4 Cytokine Release Syndrome, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Cytokine Release Syndrome, CTCAE

description: A disorder characterized by fever, tachypnea, headache, tachycardia, hypotension, rash, and/or hypoxia caused by the release of cytokines.


Grade 5 Allergic Reaction, CTCAE

description: Death


name: Grade 2 Immune System Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 1 Autoimmune Disorder, CTCAE

description: Asymptomatic; serologic or other evidence of autoimmune reaction, with normal organ function; intervention not indicated


Grade 5 Anaphylaxis, CTCAE

description: Death


name: Grade 2 Cytokine Release Syndrome, CTCAE

description: Hypotension responding to fluids; hypoxia responding to <40% O2


Grade 2 Serum Sickness, CTCAE

description: Moderate arthralgia; fever, rash, urticaria, antihistamines indicated


name: Immune System Disorders - Other, Specify, CTCAE


name: Grade 4 Immune System Disorders - Other, Specify, CTCAE


Grade 3 Allergic Reaction, CTCAE

description: Bronchospasm; hospitalization indicated for clinical sequelae; intravenous intervention indicated


Grade 4 Serum Sickness, CTCAE

description: Life-threatening consequences; pressor or ventilatory support indicated


Grade 5 Autoimmune Disorder, CTCAE

description: Death


Grade 3 Anaphylaxis, CTCAE

description: Symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension


name: Grade 5 Immune System Disorders - Other, Specify, CTCAE

description: Death


Grade 1 Allergic Reaction, CTCAE

description: Systemic intervention not indicated


Autoimmune Disorder, CTCAE

description: A disorder characterized by loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents.


Grade 3 Autoimmune Disorder, CTCAE

description: Autoimmune reactions involving major organ (e.g., colitis, anemia, myocarditis, kidney)


Allergic Reaction, CTCAE

description: A disorder characterized by an adverse local or general response from exposure to an allergen.


Anaphylaxis, CTCAE

description: A disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death.


Grade 2 Autoimmune Disorder, CTCAE

description: Evidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism)


name: Grade 1 Cytokine Release Syndrome, CTCAE

description: Fever with or without constitutional symptoms


Grade 3 Serum Sickness, CTCAE

description: Severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated


Grade 1 Serum Sickness, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 5 Cytokine Release Syndrome, CTCAE

description: Death


Grade 2 Allergic Reaction, CTCAE

description: Oral intervention indicated


Serum Sickness, CTCAE 5.0

description: A disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea.


N-tetracosenoylsphingosine

An acylsphingosine in which the acyl moiety contains 24 carbons and 1 double bond.


An N-tetracosenoylsphingosine in which the double bond in the ceramide acyl group is located at position 15 (the Z-geoisomer.


Grade 5 Anal Ulcer, CTCAE

description: Death


A perchlorometallate anion having six chlorines and rhodium(IV) as the metal component.


chlorometallate anion

An anionic coordination entity where chlorido ligands are coordinated to a metal centre.


A perchlorometallate anion having six chlorines and rhodium(III) as the metal component.


perchlorometallate anion

An anionic coordination entity where all of the ligands coordinated to the metal atom are chlorido ligands.


A perchlorometallate anion having six chlorines and ruthenium(IV) as the metal component.


A perchlorometallate anion having four chlorines and palladium(II) as the metal component.


chlorooxometallate anion

An anionic coordination entity where chlorido and oxido ligands are coordinated to a metal centre.


A perchlorometallate anion having six chlorines and palladium(IV) as the metal component.


Other inherited spinal muscular atrophy

description: Evidence of other inherited spinal muscular atrophy not specified elsewhere.


name: Carcinoma in Situ of Oral Cavity, Esophagus and Stomach

description: Evidence of carcinoma in situ of the oral cavity, esophagus and stomach.


tricaine

A methanesulfonate salt obtained by reaction of tricaine with one molar equivalent of methanesulfonic acid. Used as an anaesthetic for fish.


diarylmethane

Any compound containing two aryl groups connected by a single C atom.


name: 2,2-diphenylacetic acid 1-(1-pyrrolidinyl)propan-2-yl ester


A diarylmethane in which the two aryl groups are specified as 5-methylfuran-2-yl and pyrrol-3-yl.


name: (9R, 22R)-bisphenol A bis (9, 22-hydroxy-10, 23-anthranilicacid-propyl)


name: 2-[[[4-[[(diphenylmethyl)amino]-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]acetic acid tert-butyl ester


chlophedianol

A diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain.


A diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7).


name: 2-amino-5-[(4-amino-3-methoxycarbonylphenyl)methyl]benzoic acid methyl ester


An N-acylpiperazine that is piperazine substituted by 5-methyl-4-nitro-1,2-oxazole-3-carbonyl and bis(4-chlorophenyl)methyl groups at positions 1 and 4, respectively. It is a glutathione peroxidase 4 (GPX4) inhibitor which induces ferroptosis in cancer cells expressing the RAS oncogene.


name: 4-oxo-3-[(1-oxo-2,2-diphenylethyl)amino]-2-sulfanylidene-1H-quinazoline-7-carboxylic acid methyl ester


A diarylmethane that is diphenylmethane substituted by hydroxy group at positions 2 and 2', methoxy groups st positions 3 and 3', and propyl groups at positions 5 and 5' respectively.


name: 2,2-diphenylacetic acid (2,6-dimethylphenyl) ester


DIPHENYLMETHANE

A diarylmethane that is methane substituted by two phenyl groups.


ESMETHADONE

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder.


name: 2-(phenylmethyl)benzoic acid [2-[4-(difluoromethylthio)anilino]-2-oxoethyl] ester


(-)-methadone

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine.


benproperine

A racemate comprising equimolar amounts of (R)- and (S)-benproperine. It is used as a cough suppressant in non-productive cough.


Intrusive thoughts

description: An unwelcome and persistent idea, image or thought that is upsetting to an individual.


name: Uterine Corpus Adenosarcoma pT2a TNM Finding v8

description: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis and involving adnexa. (from AJCC 8th Ed.)


Testosterone Greater than 50 ng/dL

description: A semiquantitative finding indicating that the concentration of testosterone in a sample is greater than 50 ng/dL.


name: Grade 4 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Two Separate Tumor Masses Present in the Same Organ

description: A finding indicating the presence of two separate tumor masses in the same organ.


A 1-(5-phospho-D-ribosyl)-ATP in which the 5-phospho-D-ribosyl residue has beta-configuration at the anomeric centre.


An N-acyl-D-galactosylsphingosine in which the ceramide N-acyl group is specified as 2-hydroxylignoceroyl.


Stage IIIB Gallbladder Cancer AJCC v8

description: Stage IIIB includes: T1-3, N1, M0. T1: Tumor invading the lamina propria or muscular layer. T2: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum); or tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. T3: Tumor perforating the serosa (visceral peritoneum) and/or directly invading the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Gallbladder Cancer AJCC v8

description: Stage III includes: IIIA: (T3, N0, M0); IIIB: (T1-3, N1, M0). T1: Tumor invading the lamina propria or muscular layer. T2: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum); or tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. T3: Tumor perforating the serosa (visceral peritoneum) and/or directly invading the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Gallbladder Cancer AJCC v8

description: Stage IIIA includes: T3, N0, M0. T3: Tumor perforating the serosa (visceral peritoneum) and/or directly invading the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Rheumatoid Arthritis with Rheumatoid Factor of Right Elbow without Organ or Systems Involvement

description: Evidence of rheumatoid arthritis with rheumatoid factor of right elbow without organ or systems involvement.


name: 2-[2-(2-furanyl)-5-methyl-7-oxo-1H-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]acetic acid methyl ester


multi-methyl-branched fatty acyl-CoA

A branched-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any multi-methyl-branched fatty acid.


Pristanoyl-CoA in which C-2 of the pristanoyl group has R-configuration.


A multi-methyl-branched fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3-hydroxypristanic acid.


A medium-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 2,6-dimethylheptanoic acid.


A multi-methyl-branched fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3-oxopristanic acid.


Pristanoyl-CoA in which C-2 of the pristanoyl group has S-configuration.


The 2R stereoisomer of 2,6-dimethylheptanoyl-CoA.


pristanoyl-CoA

A multi-methyl-branched fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of pristanic acid.


A multi-methyl-branched fatty acyl-CoA having 2-hydroxyphytanoyl as the S-acyl group.


farnesoyl-CoA

A multi-methyl-branched fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of farnesoic acid.


A medium-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 4,8-dimethylnonanoic acid.


A long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (E)-2,3-didehydropristanic acid.


A multi-methyl-branched fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3,4,4-trimethylhepta-2,5-dienoic acid.


The 2S stereoisomer of 2,6-dimethylheptanoyl-CoA.


A multi-methyl-branched fatty acyl-CoA that is the S-(4,8,12-trimethyltridecanoyl) derivative of coenzyme A.


CANALINE

A non-proteinogenic L-alpha-amino acid that is L-homoserine in which the hydroxy group at position 4 is substituted by an aminooxy group. It has been isolated from legumes and plays an essential role in lugume chemical defense against insects.


name: Gastrointestinal malfunction arising from mental factors

description: A dysfunction in gastrointestinal function that is due to a psychological process.


Colorectal Cancer cM0 TNM Finding v8

description: Colorectal cancer without evidence of distant metastasis by imaging, etc.; no evidence of tumor in distant sites or organs. This category is not assigned by pathologists. (from AJCC 8th Ed.)


copper(II) phthalocyanine

A metallophthalocyanine that is copper(2+) forming a coordination complex with phthalocyanine. It is a synthetic blue pigment which is used as a colorant in paints and dyes.


name: Small Intestine Cancer pNX TNM Finding v7

description: Small intestine cancer in which regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)


AMANTADINE HYDROCHLORIDE

A hydrochloride obtained by combining amantadine and hydrochloric acid in equimolar amounts.


name: Drug or Chemical Induced Diabetes Mellitus with Hypoglycemia with Coma

description: Evidence of drug or chemical induced diabetes mellitus with hypoglycemia with coma.


bromomethanes

A halomethane that is methane in which one or more hydrogens has been replaced by bromine.


tetrabromomethane

A one-carbon compound substituted by 4 bromo groups.


Childhood Cystic Nephroma

description: A cystic nephroma that occurs in very young children.


Childhood Benign Kidney Neoplasm

description: A childhood neoplasm that arises from the kidney and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Ossifying Renal Tumor of Infancy

description: A benign neoplasm of the kidney occurring in infants. It develops as an intracalyceal mass and is characterized by the presence of osteoid formation, osteoblast-like cells, and spindle cells.


Grade 2 Growth Accelerated, CTCAE

description: >= +2 SD (standard deviation) above mid parental height or target height


Growth Accelerated, CTCAE

description: A disorder characterized by greater growth than expected for age.


name: Malignant Esophageal Neoplasm by Anatomic Region


Cervical Esophagus Adenocarcinoma

description: An adenocarcinoma that arises from the cervical esophagus.


3+ Staining

description: A finding of 3+ staining in a sample, generally indicating strong staining.


name: EC 4.6.1.1 (adenylate cyclase) inhibitor

description: An EC 4.6.* (P-O lyase) inhibitor that interferes with the action of enzyme adenylate cyclase (EC 4.6.1.1).


A secondary carboxamide that is 2-amino-1-(2-chlorophenyl)ethanol in which one of the amino hydrogens is substituted by a 2-[(2-fluorobenzyl)amino]-2-oxoethyl group.


anticapsin

An alanine derivative that is L-alanine bearing a 5-oxo-7-oxabicyclo[4.1.0]hept-2-yl substituent at position 3.


A phytoceramide in which the ceramide N-acyl group is specified as docosanoyl (behenoyl).


name: 2-methyl-2-butenoic acid [(9R,10R)-9-acetyloxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-f][1]benzopyran-10-yl] ester


3-(pyrazol-1-yl)-L-alanine zwitterion

Zwitterionic form of 3-(pyrazol-1-yl)-L-alanine having an anionic carboxy group and a protonated alpha-amino group; major species at pH 7.3.


name: Locally Advanced Renal Pelvis Urothelial Carcinoma

description: A renal pelvis urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Renal Pelvis Cancer by AJCC v8 Stage

description: A term that refers to the staging of renal pelvis cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to renal pelvis urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. It does not apply to renal cell carcinomas (are staged according to the classification for kidney), renal medullary carcinomas (are staged according to the classification for kidney), collecting duct carcinomas (are staged according to the classification for kidney),  lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and mesenchymal tumors (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs). (from AJCC 8th Ed.)


small cell carcinoma of kidney

description: A very rare small cell neuroendocrine carcinoma that arises from the kidney.


name: Unresectable Renal Pelvis Urothelial Carcinoma

description: A renal pelvis urothelial carcinoma that is not amenable to surgical resection.


Stage III Renal Cell Cancer AJCC v7

description: Stage III includes: (T1 or T2, N1, M0); (T3, N0 or N1, M0).  T1: Lesions have been divided into T1a and T1b.  T1a is defined as tumor 4 cm or less in greatest dimension, limited to the kidney.  T1b is defined as tumor greater than 4 cm but not more than 7 cm in greatest dimension, limited to the kidney. T2: Lesions have been divided into T2a and T2b.  T2a is defined as tumor more than 7 cm but less than or equal to 10 cm in greatest dimension, limited to the kidney.  T2b is defined as tumor greater than 10 cm, limited to the kidney.  T3: Tumor extends into major veins or perinephric tissues, but not into the ipsilateral adrenal gland and not beyond Gerota's fascia. Lesions have been divided into T3a, T3b, and T3c. T3a: Tumor grossly extends into the renal vein or its segmental (muscle containing) branches, or tumor invades perirenal and/or renal sinus fat but not beyond Gerota's fascia.  T3b: Tumor grossly extends into the vena cava below the diaphragm. T3c: Tumor grossly extends into the vena cava above the diaphragm or invades the wall of the vena cava.  N0: No regional lymph node metastasis.  N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (AJCC 7th ed.)


Stage I Renal Cell Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 7 cm or less in greatest dimension, limited to the kidney. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Renal Pelvis Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Metastatic Chromophobe Renal Cell Carcinoma

description: Chromophobe renal cell carcinoma that has spread from the original site of growth to another anatomic site.


Stage III Renal Pelvis Cancer AJCC v7

description: Stage III includes: T3, N0, M0.  T3: Tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  N0: No lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Eosinophilic Solid and Cystic Renal Cell Carcinoma

description: A renal cell carcinoma associated with biallelic somatic mutations in the TSC1 or TSC2 genes and characterized by the presence of neoplastic polygonal cells with abundant eosinophilic cytoplasm and cystic changes.


name: Unresectable Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that is not amenable to surgical resection.


ALK-Rearranged Renal Cell Carcinoma

description: An extremely rare renal cell carcinoma characterized by the presence of chromosomal translocations involving the chromosome 2p23 breakpoint that result in gene fusions between the anaplastic lymphoma kinase gene (ALK) and various gene partners.


Metastatic Kidney Medullary Carcinoma

description: Kidney medullary carcinoma that has spread to another anatomical site.


name: Chromophobe Renal Cell Carcinoma Associated with Birt-Hogg-Dube Syndrome

description: Chromophobe renal cell carcinoma that develops in a patient with Birt-Hogg-Dube syndrome.


name: Refractory Clear Cell Renal Cell Carcinoma

description: Clear cell renal cell carcinoma that is resistant to treatment.


name: Metastatic Sarcomatoid Renal Cell Carcinoma

description: Sarcomatoid renal cell carcinoma that has spread to another anatomical site.


Childhood Kidney Carcinoma

description: A kidney carcinoma that occurs during childhood.


Stage IV Renal Cell Cancer AJCC v8

description: Stage IV includes: (T4, Any N, M0); (Any T, Any N, M1). T4: Tumor invading beyond Gerota's fascia (including contiguous extension into the ipsilateral adrenal gland). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 4 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by extreme nuclear pleomorphism and/or sarcomatoid and/or rhabdoid differentiation and/or tumor giant cells. (WHO, 1982 /ISUP 2014)


name: Recurrent Chromophobe Renal Cell Carcinoma

description: The reemergence of chromophobe renal cell carcinoma after a period of remission.


name: Recurrent Renal Pelvis Urothelial Carcinoma

description: The reemergence of renal pelvis urothelial carcinoma after a period of remission.


Unresectable Kidney Carcinoma

description: A kidney carcinoma that is not amenable to surgical resection.


name: Locally Advanced Kidney Medullary Carcinoma

description: Kidney medullary carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: BAP1-Mutant Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma that is associated with a mutation in BAP1 gene. These tumors are typically high grade and associated with poor outcome.


name: Metastatic Renal Pelvis Urothelial Carcinoma

description: Renal pelvis urothelial carcinoma that has spread to another anatomical site.


Stage I Renal Cell Carcinoma

description: Stage I includes: T1, N0, M0.  T1: Lesions have been divided into T1a and T1b.  T1a is defined as tumor 4 cm or less in greatest dimension, limited to the kidney.  T1b is defined as tumor greater than 4 cm but not more than 7 cm in greatest dimension, limited to the kidney.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


name: Childhood Eosinophilic Solid and Cystic Renal Cell Carcinoma

description: An eosinophilic solid and cystic renal cell carcinoma that occurs during childhood.


name: Locally Advanced Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that has spread to nearby tissues or lymph nodes.


name: Locally Advanced Papillary Renal Cell Carcinoma

description: Papillary renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Renal Cell Carcinoma Associated with t(X;17)(p11.2;q25)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;q25) resulting in fusion of the ASPL and TFE3 genes.


Stage II Renal Pelvis Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage II Renal Cell Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor measuring more than 7 cm in greatest dimension, limited to the kidney. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Kidney Carcinoma

description: The reemergence of kidney carcinoma after a period of remission.


name: Renal Pelvis Urothelial Carcinoma, High Grade

description: Renal pelvis urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


name: Locally Advanced Clear Cell Renal Cell Carcinoma

description: Clear cell renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Renal Cell Carcinoma Associated with inv(X)(p11;q12)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the inv(X)(p11;q12) resulting in fusion of the NONO (p54nrb) and TFE3 genes.


Metastatic Kidney Carcinoma

description: A carcinoma that arises from the kidney and has metastasized to another anatomic site.


name: Unresectable Sarcomatoid Renal Cell Carcinoma

description: A sarcomatoid renal cell carcinoma that is not amenable to surgical resection.


name: Unresectable Chromophobe Renal Cell Carcinoma

description: A chromophobe renal cell carcinoma that is not amenable to surgical resection.


name: Renal Cell Carcinoma, Not Otherwise Specified

description: A renal cell carcinoma that cannot be classified into one of the established subtypes of renal cell carcinoma.


name: Non-Hereditary Clear Cell Renal Cell Carcinoma

description: The most common type of renal cell carcinoma, characterized by a loss of genetic material of the short arm of chromosome 3.  The most common symptom at the time of diagnosis is hematuria.  The tumor has a golden-yellow color because of the abundance of intracytoplasmic lipid.  This is a clinically aggressive type of renal cell carcinoma.  The tumor usually metastasizes to unusual sites and late metastasis is common.


Stage II Renal Cell Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Lesions have been divided into T2a and T2b.  T2a is defined as tumor more than 7 cm but less than or equal to 10 cm in greatest dimension, limited to the kidney.  T2b is defined as tumor greater than 10 cm, limited to the kidney.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations

description: A renal cell carcinoma with constitutional chromosome 3 translocations.


name: Locally Advanced Chromophobe Renal Cell Carcinoma

description: Chromophobe renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Refractory Renal Pelvis Urothelial Carcinoma

description: Renal pelvis urothelial carcinoma that is resistant to treatment.


name: Metastatic Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that has spread from the original site of growth to another anatomic site.


Unresectable Kidney Medullary Carcinoma

description: A kidney medullary carcinoma that is not amenable to surgical resection.


Stage III renal cell cancer

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0); (T3a, N0, M0); (T3a, N1, M0); (T3b, N0, M0); (T3b, N1, M0); (T3c, N0, M0); (T3c, N1, M0). T3: Tumor extends into major veins or invades adrenal gland or perinephric tissues but not beyond Gerota's fascia.  T3a: Tumor directly invades adrenal gland or perirenal and/or renal sinus fat but not beyond Gerota's fascia.  T3b: Tumor grossly extends into the renal vein or its segmental (muscle containing) branches, or vena cava below the diaphragm.  T3c: Tumor grossly extends into the vena cava above the diaphragm or invades the wall of the vena cava.  N0: No regional lymph node metastases.  N1: Metastasis in a single regional lymph node. M0: No distant metastasis.  (AJCC 6th Ed.)


Non-Clear Cell Renal Cell Carcinoma

description: A group of renal cell carcinomas characterized by the absence of lipid-containing clear adenocarcinoma cells. This category includes the following morphological subtypes: papillary renal cell carcinoma; sarcomatoid renal cell carcinoma; chromophobe renal cell carcinoma; tubulocystic renal cell carcinoma; and eosinophilic solid and cystic renal cell carcinoma.


name: Locally Recurrent Clear Cell Renal Cell Carcinoma

description: The reemergence of clear cell renal cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Renal Cell Cancer by AJCC v8 Stage

description: A term that refers to the staging of kidney cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas arising in the kidney. It does not apply to urothelial carcinomas (are staged according to the classification for renal pelvis and ureter), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs), and Wilms tumor (no AJCC staging system). (from AJCC 8th Ed.)


name: Childhood SMARCB1-Deficient Kidney Medullary Carcinoma

description: A SMARCB1-deficient kidney medullary carcinoma that occurs during childhood.


Metastatic Renal Pelvis Carcinoma

description: Renal pelvis carcinoma that has spread from the original site of growth to other anatomic sites.


name: Metastatic Papillary Renal Cell Carcinoma

description: A papillary renal cell carcinoma that has spread from the original site of growth to another anatomic site.


name: Early Stage Clear Cell Renal Cell Carcinoma

description: A stage term referring to clear cell renal cell carcinoma that presents as a small tumor and is confined to the kidney.


Stage II Renal Cell Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor more than 7 cm in greatest dimension limited to the kidney.  N0: No regional lymph node metastases.  M0: No distant metastasis. (AJCC 6th Ed.)


Recurrent Kidney Medullary Carcinoma

description: The reemergence of kidney medullary carcinoma after a period of remission.


name: Renal Cell Carcinoma Associated with t(X;1)(p11.2;q21)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;q21) resulting in fusion of the PRCC and TFE3 genes.


Renal Pelvis Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal pelvis cancer according to the American Joint Committee on Cancer, 7th edition.


Refractory Kidney Medullary Carcinoma

description: A kidney medullary carcinoma that does not respond to treatment.


Refractory Renal Cell Carcinoma

description: Renal cell carcinoma that does not respond to treatment.


Grade 3 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 100 magnification. (WHO 1982 /ISUP 2014)


Locally Advanced Renal Cell Carcinoma

description: Renal cell carcinoma that has spread to nearby tissues or lymph nodes.


Stage III Renal Pelvis Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Transplant-Related Renal Cell Carcinoma

description: A renal cell carcinoma that arises in a patient with a history of organ transplantation.


Stage IV Renal Cell Cancer

description: Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades beyond Gerota's fascia.  N0: No regional lymph node metastases.  N1: Metastasis in a single regional lymph node.  N2: Metastasis in more than one regional lymph node.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 6th ed.)


ELOC-Mutated Renal Cell Carcinoma

description: A renal cell carcinoma characterized by the presence of mutations in the ELOC (TCEB1)  gene at 8q21.11.


name: Renal Cell Carcinoma Associated with t(X;1)(p11.2;p34)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;p34) resulting in fusion of the PSF and TFE3 genes.


Renal Cell Cancer by AJCC v6 Stage

description: A term that refers to the staging of renal cell cancer according to the American Joint Committee on Cancer, 6th edition.


Kidney Carcinoma Molecular Subtypes

description: A term that refers to the classification of kidney carcinomas according to their molecular characteristics.


name: Succinate Dehydrogenase-Deficient Renal Cell Carcinoma

description: A very rare renal cell carcinoma that usually affects young adults. It is characterized by mutations in one of the four subunits of the SDH complex (SDHA, SDHB, SDHC, or SDHD gene). Most frequently, the mutations occur in the SDHB subunit. It has a relatively good prognosis.


Unresectable Renal Cell Carcinoma

description: A renal cell carcinoma that is not amenable to surgical resection.


Stage IV Renal Cell Cancer AJCC v7

description: Stage IV includes: (T4, Any N, M0); (Any T, Any N, M1). T4: Tumor invades beyond Gerota's fascia (including contiguous extension into the ipsilateral adrenal gland).  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


Grade 2 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 400 magnification, and visible but not prominent at x 100 magnification. (WHO 1982 /ISUP 2014)


Grade 1 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by absent or inconspicuous and basophilic nucleoli at x 400 magnification. (WHO 1982 /ISUP 2014)


Locally Advanced Renal Pelvis Carcinoma

description: Renal pelvis carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Kidney Carcinoma

description: Kidney carcinoma that has spread to nearby tissues or lymph nodes.


Renal cell carcinoma recurrent

description: A reemergence of renal cell carcinoma after a period of remission.


Metastatic Renal Cell Carcinoma

description: Renal cell carcinoma that has spread from the kidney to other anatomic sites.


Localized Renal Cell Carcinoma

description: A renal cell carcinoma that is mainly confined to the kidney with or without involvement of perinephric tissues and without evidence of spread to other organs.


Kidney Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Stage IV Renal Pelvis Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


name: Locally Advanced Sarcomatoid Renal Cell Carcinoma

description: Sarcomatoid renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Recurrent Clear Cell Renal Cell Carcinoma

description: The reemergence of clear cell renal cell carcinoma after a period of remission.


name: Unresectable Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma that is not amenable to surgical resection.


Stage III Renal Cell Cancer AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: Tumor measuring 7 cm or less in greatest dimension, limited to the kidney. T2: Tumor measuring more than 7 cm in greatest dimension, limited to the kidney. T3: Tumor extending into major veins or perinephric tissues, but not into the ipsilateral adrenal gland and not beyond Gerota's fascia. N0: No regional lymph node metastasis. N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (AJCC 8th ed.)


Renal Cell Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal cell cancer according to the American Joint Committee on Cancer, 7th edition.


Stage I Renal Pelvis Cancer AJCC v7

description: Stage I includes: T1, M0, M0.  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Childhood ALK-Rearranged Renal Cell Carcinoma

description: An ALK-rearranged renal cell carcinoma that occurs during childhood.


Refractory Kidney Carcinoma

description: Kidney carcinoma that is resistant to treatment.


Reiter's Disease, Left Hand

description: Evidence of Reiter's disease in the left hand.


Grade 1 Infantile Vomiting, AE

description: An adverse event in a newborn characterized by an increase in vomiting over baseline, self limiting.


Infantile Vomiting, AE

description: An adverse event in a newborn characterized by expulsion of the contents of the stomach through the mouth.


Grade 2 Infantile Vomiting, AE

description: An adverse event in a newborn characterized by a persistent increase in vomiting over baseline; no dehydration; minor changes in feeding support indicated.


Grade 5 Infantile Vomiting, AE

description: A vomiting adverse event in a newborn which results in death.


Grade 4 Infantile Vomiting, AE

description: A vomiting adverse event in a newborn characterized by life-threatening consequences (e. g. severe dehydration).


Grade 3 Infantile Vomiting, AE

description: An adverse event in a newborn characterized by a persistent increase in vomiting over baseline; signs of dehydration; major changes in feeding support indicated (e.g. change to total parenteral nutrition (TPN) or gavage).


name: N-[[2-(1-piperidinyl)-4-thiophen-2-yl-5-thiazolyl]methylideneamino]carbamic acid methyl ester


name: Grade 1 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


lambda-cyhalothrin

Reaction product comprising equal quantities of CHEBI:39323 and CHEBI:39327.


QUINIZARIN

A dihydroxyanthraquinone having the two hydroxy substituents at the 1- and 4-positions; formally derived from anthraquinone by replacement of two hydrogen atoms by hydroxy groups


Grade 5 Bladder Perforation, CTCAE

description: Death


chalcopyrite

A sulfide mineral with formula CuFeS2. Chalcopyrite is the most important copper ore


The stable isotope of copper with relative atomic mass 62.929601, 69.2 atom percent natural abundance and nuclear spin 3/2.


name: heptakis-L-histidino tetracopper mu4-sulfide hydroxide


elesclomol-Cu(II)

The copper coordination entity formed from elesclomol by coordination to copper via the thiocarbonyl and hydrazino groups.


cupric chloride

An inorganic chloride of copper in which the metal is in the +2 oxidation state.


copper-sulfur cluster

A copper-sulfur cluster is a unit comprising two or more copper atoms and bridging sulfur ligand(s).


A 1-acyl-sn-glycero-3-phosphoethanolamine zwitterion obtained by transfer of a proton from the amino to the phosphate group of 1-oleoyl-sn-glycero-3-phosphoethanolamine.


A lysophosphatidylethanolamine zwitterion in which the remaining acyl group (position not specified) contains 18 carbons and 1 double bond.


A 2-acyl-sn-glycero-3-phosphoethanolamine zwitterion obtained by transfer of a proton from the phosphate to the amino group of 2-oleoyl-sn-glycero-3-phosphoethanolamine; major species at pH 7.3.


A lysophosphatidylethanolamine zwitterion in which the remaining acyl group (position not specified) contains an oleoyl chain.


An oxoicosatetraenoic acid that is (5Z,8Z,12E,14Z)-icosatetraenoic acid bearing a single oxo substituent located at position 12.


Grade 1 Allergic Rhinitis, CTCAE

description: Mild symptoms; intervention not indicated


Allergic Rhinitis, CTCAE

description: A disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching.


Grade 2 Allergic Rhinitis, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Drug or Chemical Induced Diabetes Mellitus with Proliferative Diabetic Retinopathy with Macular Edema, Left Eye

description: Evidence of drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with macular edema in the left eye.


A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.


name: Invasive Adenocarcinoma in Adenomatous Polyp

description: An invasive adenocarcinoma that arises in an adenomatous polyp.


name: Cutaneous T-Cell Lymphoma, Unspecified, Extranodal and Solid Organ Sites

description: Evidence of unspecified cutaneous T-cell lymphoma in the extranodal and solid organ sites.


escitalopram

A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.


name: Other Specified Malignant Neoplasm of Skin of Lip

description: Evidence of other specified malignant neoplasm of skin of lip not specified elsewhere.


A long-chain fatty alcohol that is pentadecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group


Post-Procedural Pain

description: Pain experienced after a medical intervention through the time expected for associated acute effects to abate.


A 1,2-diacyl-sn-glycero-3-phosphoethanolamine zwitterion in which the acyl groups at C-1 and C-2 contain 44 carbons in total with 4 double bonds.


valienone 7-phosphate

A hydroxyalkyl phosphate that is valienone carrying a single monophosphate substituent at position 7.


2,3-saturated fatty acid

Any fatty acid in which the first two carbons of the chain attached to the carboxy group are saturated and unbranched.


A  dihydroxyflavanone that is pinocembrin substituted by a methyl group at position 8. It has been isolated from the buds of Cleistocalyx operculatus.


Pseudocyst

description: A cyst-like structure that lacks an epithelial lining.


Skullcap Lesion

description: A neoplastic, inflammatory, or vascular process in the roof of the skull.


name: Grade 4 CNS Necrosis and Cystic Progression, CTCAE


name: Other Pre-Existing Diabetes Mellitus in Childbirth

description: Evidence of other pre-existing diabetes mellitus in childbirth not specified elsewhere.


name: Grade 1 Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


name: Grade 2 Radiation Recall Reaction (Dermatologic), CTCAE

description: Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema


Breast Cancer pN1a TNM Finding v8

description: Breast cancer with metastases in 1-3 axillary lymph nodes, at least one metastasis larger than 2.0 mm. (from AJCC 8th Ed.)