Cholesterol Deposit

description: Deposition of cholesterol in the skin. It appears as a slightly elevated and yellow bump usually in the skin around the eyes.


name: Bone Marrow Lymphoplasmacytic Infiltration of Less than 10%

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A morphologic finding indicating the presence of a lymphoplasmacytic infiltrate in the bone marrow, comprising less than 10% of the cellular population.


Smooth Muscle Metaplasia

description: A morphologic finding indicating the transformation of non-smooth muscle cells to smooth muscle cells.


name: Estrogen Receptor Positive by Immunohistochemistry 1-9 Percent

description: An immunohistochemical staining finding indicating that between 1 and 9 percent of the cells in a tissue sample are expressing estrogen receptor.


name: More than 1 Mitosis per 50 HPF and Less than 3 Mitoses per 10 HPF

description: A microscopic finding indicating the presence of more than one mitotic figure per fifty high power fields and less than three mitotic figures per ten high power fields in a sample.


Reticulin Fibrosis of the Bone Marrow

description: Increased reticular fiber deposition within bone marrow.


Muscle Invasion

description: A morphologic finding indicating the presence of a malignant cellular infiltrate invading muscle in a tissue sample.


Pelvic soft tissue necrosis

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A necrotic process affecting the soft tissues of the pelvis.


Fungus Present

description: Confirmatory presence of fungal microorganisms.


Margin of XRT Field

description: The outer aspect of the x-ray therapy field.


name: Mesenchymal Metaplasia of Malignant Cells Present


name: Neoplastic Cells with CD45 Dim-to-Negative Expression Present

description: An immunophenotypic finding indicating the presence of neoplastic cells with dim-to-negative CD45 expression.


name: Fair Tissue Fixation with Definable Architectural Characteristics


CD1a-Positive Neoplastic Cells Present

description: An indication that expression of CD1A has been detected in a sample of neoplastic cells.


Mesonephric Differentiation

description: A morphologic finding indicating the presence of a cellular infiltrate exhibiting tubular, ductal, papillary, sieve-like, and solid patterns. Eosinophilic, colloid-like material may be present in the tubules.


High Grade Transformation

description: Dedifferentiation of a malignant neoplasm.


name: Estrogen Receptor Positive by Immunohistochemistry Less than 20 Percent

description: An immunohistochemical staining finding indicating that less than 20 percent of the cells in a tissue sample are expressing estrogen receptor.


Cancerization of Pancreatic Ducts

description: The spread of invasive pancreatic ductal carcinoma along pancreatic ducts and ductules. Histologically, this process can mimic high-grade pancreatic intraepithelial neoplasia.


name: Lymphoblasts with Surface Immunoglobulin Present

description: A microscopic finding indicating that immunoglobulins are bound to or expressed on the surface of the immature lymphoid cells in a sample.


Squamous Dysplasia

description: A morphologic finding indicating the presence of dysplasia in the squamous epithelium of a tissue sample.


CD52-Positive Neoplastic Cells Present

description: An indication that expression of CD52 has been detected in a sample of neoplastic cells.


Cytoplasmic Vacuolation

description: A morphologic finding referring to the presence of vacuoles within the cytoplasm of the cells.


Ossicle Pattern

description: A morphologic finding indicating the presence of small bone formations in a tumor sample.


name: Grossly Negative and Microscopically Positive Surgical Margin

description: The presence of microscopically visible residual tumor at the edge of a surgically excised specimen that otherwise looks macroscopically normal.


name: Variably-Sized Cysts Filled With Clear, Serous, or Gelatinous Fluid

description: A morphologic finding indicating the presence of variably-sized cysts filled with clear, serous, or gelatinous fluid in a tissue sample.


name: Loss or Reduction of Nuclear Histone H3 K28me3 Expression

description: A molecular genetic finding indicating the loss or reduction of nuclear histone H3 K28me3 (K27me3) expression in tumor cells.


name: Morphologic Features Resembling Salivary Gland Adenocarcinoma

description: A morphologic finding indicating that an adenocarcinoma which arises from a site other than the salivary glands, resembles a salivary gland adenocarcinoma.


name: Estrogen Receptor Positive by Immunohistochemistry 21-30 Percent

description: An immunohistochemical staining finding indicating that 21-30 percent of the cells in a tissue sample are expressing estrogen receptor.


Progesterone Receptor Status 3+

description: An immunohistochemical result of 3 for progesterone receptor expression that is considered positive for expression.


Indeterminate Growth Phase

description: A response that the growth phase is undetermined.


Respiratory Tract Epithelial Alteration

description: A change or slight modification in the epithelial cells along the respiratory tract.


Increased Granules

description: Increased number and/or size of granules in the cytoplasm of cells.


name: Intracytoplasmic Eosinophilic Spherical Inclusion


name: Multiple Serpentine Pseudopalisading Pattern

description: A morphologic finding referring to the presence of multiple foci of serpentine necrosis and glial cell perivascular pseudopalisading in a glioma.


name: Fibrotic Stroma with Finger-Like Projections Present


name: MART-1-Positive Neoplastic Cells Present


name: Intracytoplasmic Mucin Present in 50% or Less of Malignant Cells

description: A morphologic finding indicating the presence of intracytoplasmic mucin in 50% or less of malignant cells in a tumor sample.


name: Germ Cell Depletion and Germ Cell Degeneration

description: A finding of both germ cell depletion and germ cell degeneration.


Gastrointestinal Stoma Necrotic Lesion

description: A necrotic process affecting the post-operative stoma area in the gastrointestinal tract.


name: Mixed Malignant Epithelial Cell Population

description: A morphologic finding indicating the presence of a mixed population of malignant epithelial cells in a tumor sample.


Invasive Lesion

description: A malignant cellular population that has increased in size and infiltrates the surrounding tissues.


name: Confluent Sheets of Neoplastic B-Lymphocytes Present


Acute Inflammatory Infiltrate

description: A morphologic finding indicating the presence of neutrophils and/or eosinophils in a tissue sample.


name: Progesterone Receptor Positive by Immunohistochemistry 91-100 Percent

description: An immunohistochemical staining finding indicating that 91-100 percent of the cells in a tissue sample are expressing progesterone receptor.


name: Dense Eosinophilic Basement Membrane Deposit

description: Accumulation of dense eosinophilic deposits in the basement membrane.


name: Individual Cells Surrounded by Reticulin Present


Non-Papillary Pattern

description: A morphologic finding indicating the presence of a cellular infiltrate without a papillary growth in a tissue sample.


Fallopian Tube Mucinous Metaplasia

description: Metaplastic mucinous changes in the fallopian tube epithelium. It may be seen in association with gynecological, appendiceal, or colonic mucinous tumors, or chronic inflammation.


Hyaline Material

description: Presence of exogenous or endogenous hyaline material within the thymus or other organ or tissue.


Anal Necrotic Lesion

description: A necrotic process involving the area of the anus.


Polymorphonuclear Cell Infiltrate

description: A morphologic finding referring to an acute inflammatory infiltrate that is composed of polymorphonuclear cells.


Extravascular Matrix Loops

description: A microscopic finding indicating the presence or absence of extravascular matrix loops in uveal melanoma.


name: Macroscopically Positive Surgical Margin

description: The presence of macroscopically visible residual tumor at the edge of a surgically excised specimen.


Foamy Cell Proliferation

description: A morphologic finding indicating the presence of xanthomatous cells in a tissue sample.


Chronic Plasma Cell Deciduitis

description: The presence of decidual plasma cells, scattered or in aggregate.


name: PD-L1 Expression Positive in Myeloid-Derived Suppressor Cells

description: An immunohistochemical test result indicating that expression of PD-L1 was detected in myeloid-derived suppressor cells (MDSCs). PD-L1 expression is significantly higher in tumor-infiltrating MDSCs than in MDSCs found in secondary lymphoid organs, bone marrow or peripheral blood and decreasing levels of PD-L1 positive MDSCs in samples taken serially during antitumor treatment may correlate with increased therapeutic efficacy.


Macrocytosis (morphologic abnormality)

description: An increase in nuclear size and amount of cytoplasm of a cell. The cells or nucleus may be slightly irregular and/or may be polyploid.


name: Cytoplasmic Accumulation of Black Pigment

description: A morphologic finding indicating the presence of black pigment within the cytoplasm of cells in a tissue sample.


Intracytoplasmic Lipofuscin Present

description: A morphologic finding indicating the presence of fine granular yellowish-brownish pigment within the cytoplasm of the cells in a tissue sample.


Tumor Margin Configuration

description: Describes the morphologic appearance where a tumor meets the adjacent tissue.


name: Low Expression Pattern of Neuroendocrine Markers Present

description: A finding indicating low expression of neuroendocrine markers in a tumor sample.


Non-Melanomatous Lesion

description: A lesion characterized by the absence of clinical and/or morphologic criteria that are suggestive of melanoma.


Micropapillary Growth Pattern

description: A morphologic finding indicating the presence of a growth pattern dominated by the presence of small papillary structures.


PD-L1 Overexpression

description: An immunohistochemical test result that indicates overexpression of PD-L1 in a tissue sample of a primary or metastatic malignant neoplasm.


name: Progesterone Receptor Positive by Immunohistochemistry Less than or Equal to 9 Percent

description: An immunohistochemical staining finding indicating that at most 9 percent of the cells in a tissue sample are expressing progesterone receptor.


Small Cell Dysplasia

description: A premalignant neoplastic lesion of the liver.  It is characterized by the presence of hepatocytes with decreased cell volume, increased nuclear/cytoplasmic ratio, basophilia, mild nuclear pleomorphism, and hyperchromasia.


name: Scattered Interstitial Eosinophils Present

description: A morphologic finding indicating the presence of eosinophils scattered in the interstitial spaces of a tissue sample.


Mucin Depletion

description: A morphologic and histochemical finding indicating depletion of mucin in the glands.


Negative Surgical Margin

description: Indicates the absence of tumor cells at the edge of a surgically excised specimen.


name: Renal Dysplasia Due to Fetal Exposure to ACE Inhibitor or ARB

description: Tubular dysgenesis resulting from maternal exposure to a class of drugs known as angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB).


Primitive Mesenchymal Stroma Formation

description: A morphologic finding indicating the presence of a primitive mesenchymal stroma in a tumor sample.


Gland Distortion

description: Architectural distortion of the tissue structure of a gland.


name: Peribronchial and Lobular Septal Involvement Only


Perinuclear Halo Present

description: A morphologic finding referring to the presence of a vacuolated area that surrounds the nucleus.  It results from nuclear shrinking.


Regenerative Epithelium Present

description: A morphologic finding indicating epithelial regrowth following injury.


name: Superficial NK-Cell Infiltrate Present in Gastrointestinal Tract

description: A finding indicating the presence of a superficial NK-cell infiltrate in the gastrointestinal tract.


Endothelial Attenuation

description: Endothelial cell enlargement and other adaptations for injury or aging-induced cell loss and decreased endothelial cell function.


Hematogenous CSF Blasts

description: A morphologic finding indicating the presence of blasts in a sample of cerebrospinal fluid.


Focal Cortical Dysplasia

description: A congenital cortical developmental abnormality characterized by focal architectural distortion of the cortical brain layers. It is associated with the presence of cytologic abnormalities including hypertrophic and dysmorphic neurons. It is caused by genetic or acquired factors and is often associated with epilepsy.


Hyperchromasia

description: A morphologic finding referring to the presence of darkly stained nuclei due to abundance of DNA on hematoxylin-eosin stained sections.  It is suggestive of malignancy.


name: Ki-67 Positive Cells Less than or Equal to 10 Percent

description: A semi-quantitative microscopic finding indicating that 10 percent or less of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Pharyngeal necrosis

description: A necrotic process affecting the pharynx.


Multinodular and Vacuolated Pattern

description: An architectural pattern characterized by the presence of neoplastic cells forming multiple nodules with prominent vacuolation.


Biopsy Finding

description: A description of the findings from a biopsy.


Apocrine metaplasia

description: A morphologic finding indicating the alteration of the glandular acinar epithelial cells to apocrine sweat gland cells.


Epiphysitis

description: Disorganization of the physeal chondrocytes with or without increased thickness of physis.


name: PSMA-Positive Extracellular Vesicles High

description: An indication that extracellular vesicles expressing PSMA (PSMA-EVs) were found at high concentrations in a sample. High levels of PSMA-EVs are seen in samples from subjects with malignant urologic cancers, including metastatic renal cell carcinoma (RCC), metastatic prostate cancer, and castration-resistant prostate cancer.


Non-Invasive Lesion

description: A neoplastic process that is confined to the site of origin without morphologic evidence of cellular infiltration of the surrounding tissues.


Hypocellular Tissue

description: A morphologic finding indicating the presence of a small population of cells in a tissue sample.


Margin Involved by Sarcoma

description: The margin of the sample has sarcoma.


Thin-Branching Papillae Present

description: A morphologic growth pattern indicating the presence of papillary structures forming thin branches.


Degeneration And Vacuolation

description: A finding that generally has features of degeneration and vacuolation.


Adult Extramedullary Hematopoiesis

description: Extramedullary hematopoiesis occurring during adulthood.


Clark Level I

description: A morphologic finding indicating that the cutaneous melanoma is confined to the epidermis and does not invade the dermis.


CD8-Positive Neoplastic Cells Present

description: An indication that expression of CD8 has been detected in a sample of neoplastic cells.


name: Spindle Cell Osteo-Fibrous Component Present


Vertical Growth Phase

description: A morphologic architectural pattern in which the tumor cells spread vertically.


Invasion of Muscularis Mucosa Present

description: A morphologic finding indicating the presence of a malignant cellular infiltrate invading the muscularis mucosa.


Submucosal 1 Invasion

description: Submucosal tumor invasion into the upper third of the submucosal tissue.


name: No Evidence of Distinct Lineage Differentiation Present

description: A finding indicating that there is no evidence of distinct cell lineage differentiation in a tumor sample.


description: A morphologic finding indicating the proliferation of spindle-shaped myofibroblasts within vascular spaces in a tissue sample.


Single Cell Necrosis

description: A morphologic finding indicating the presence of individual necrotic cells surrounded by viable cells in a tissue sample.


Membranous Positivity Present

description: An immunophenotypic finding indicating positive membranous reactivity to a specific antibody.


name: Cytoplasmic Eosinophilic Globules Present


Collagenous Stroma Formation

description: A morphologic finding indicating the presence of dense stromal fibrosis in a tissue sample.


name: Human Chorionic Gonadotropin-Positive Neoplastic Cells Present


name: Anastomosing Cells Connected to the Basal Layer of the Epidermis Present


More than 5 Mitoses per 50 HPF

description: A morphologic finding indicating the presence of more than five mitotic figures per fifty high power fields in a cellular infiltrate.


name: Germinal Centers with Prominent Hyalinized Vessels Present


Intramucosal Neutrophilic Infiltrate

description: A morphologic finding indicating the presence of a neutrophilic infiltrate within the mucosa of a tissue sample.


Architectural Distortion

description: A morphologic finding indicating alteration of the shape/pattern of tissue components.


Congenital Dysplasia

description: Abnormal tissue formation due to abnormal cellular organization, which may result in a morphologic defect.


Tumor Vascular Invasion

description: A term referring to the presence of tumor emboli or tumor masses within any circulatory vessel.


name: Squamous Metaplasia of Malignant Cells Present


Clark Level IV

description: A morphologic finding indicating that the cutaneous melanoma has invaded the reticular dermis.


Questionable Invasive Lesion

description: A neoplastic lesion in which the adjacent tissues, surrounding capsule, or vessels may or may not be invaded by neoplastic cells.


Bronchial Epithelial Dysplasia

description: A non-invasive, precancerous lesion in the bronchial epithelium. Depending on the morphologic features it is classified as columnar cell dysplasia, basal cell dysplasia, squamous dysplasia, or bronchial epithelial dysplasia with transitional differentiation.


name: High Expression Pattern of Neuroendocrine Markers Present

description: A finding indicating high expression of neuroendocrine markers in a tumor sample.


Minimal Submucosal Invasion

description: A morphological finding indicating the minimum depth of tumor invasion into the submucosal tissue.


Necrosis and Infiltrate

description: A morphologic finding indicating the presence of necrosis associated with a cellular infiltrate in a tissue sample.


name: Massive Sinusoidal Histiocytic Infiltrate


name: Glomerular Basement Membrane Spikes Present

description: A finding indicating the presence of protrusions or extensions in the basement membrane of the glomeruli.


Pathologic Intimal Thickening

description: A term that refers to a vascular lesion characterized by an extracellular lipid pool with intimal smooth muscle cell loss typically adjacent to the medial wall in addition to varying degrees of macrophage infiltration near the lumen. (Arteriosclerosis, Thrombosis, and Vascular Biology. 2007; 27:986-989)


name: Gastrointestinal Type Epithelium Present


name: Widespread Alveolar Pneumocyte Damage Present

description: A morphologic finding indicating the presence of extensive injury of the alveolar pneumocytes in a lung tissue sample.


Squamous Differentiation

description: A microscopic finding indicating the presence of cells with squamous differentiation in a tumor sample.


name: Sheets of Interfollicular Plasma Cells Present


Severe Immune Presence

description: Greater than 50 percent of the tissue surface area is occupied by immune cell infiltration.


Ground Glass Nuclear Inclusion

description: A microscopic finding indicating the presence of nuclei with ground glass appearance due to the presence of intranuclear viral particles that cause peripheral margination of the chromatin.


name: Proliferation of Basaloid Cells Parallel to the Long Axis of the Epidermis Present


Cellular Dedifferentiation

description: A morphologic finding indicating the presence of a high-grade cellular component adjacent to or admixed with a low-grade cellular infiltrate.


Microsatellitosis Absent

description: An indication that microsatellitosis is absent.


Ki-67 Positive Cells 10-20 Percent

description: A semi-quantitative microscopic finding indicating that between 10 and 20 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Lung Squamous Dysplasia

description: A morphologic finding indicating the presence of dysplasia in the bronchial squamous epithelium. It is precursor of lung squamous cell carcinoma.


name: Mitotic Rate Less than One per Square Millimeter

description: A finding of a mitotic rate less than one per square millimeter.


Poorly Differentiated Lesion

description: A lesion comprised of neoplastic cells that generally have lost most of the morphological features that are indicative of normal cells.


Dysplasia of larynx

description: Mild, moderate, or severe dysplasia of the squamous epithelium of the laryngeal mucosa.


name: Synaptophysin-Positive Neoplastic Cells Present

description: An immunophenotypic test result indicating positive staining of neoplastic cells for synaptophysin.


Severe dysplasia

description: A morphologic finding indicating the presence of severe cellular atypia associated with severe architectural changes in a tissue sample.


name: Serotonin-Positive Neoplastic Cells Present


Tumor Infiltrating Lymphocyte Absent

description: A response that there are no tumor infiltrating lymphocytes.


Focal fibrosis

description: Localized formation of fibrous tissue.


Apoptosis and Necrosis

description: A finding that generally has features of degeneration and necrosis.


CD57-Positive Neoplastic Cells Present

description: An indication that expression of CD57 has been detected in a sample of neoplastic cells.


name: Progesterone Receptor Positive by Immunohistochemistry 71-80 Percent

description: An immunohistochemical staining finding indicating that 71-80 percent of the cells in a tissue sample are expressing progesterone receptor.


Entrapped Gray Matter Present

description: A morphologic finding that refers to the presence of ectopic gray matter in a tissue sample.


MUC1*-Positive Cells Present

description: An indication that the cells in sample have cell surface expression of antibody-detectable amounts of a specific membrane-bound fragment of the mucin-1 protein (MUC1), which results from extramembrane cleavage, has growth factor receptor-like activity and is comprised of the cytoplasmic tail, the transmembrane domain and at least forty-five amino acids of the extracellular domain.


Glycogen-Rich Component Present

description: A morphologic finding indicating the presence of cells with glycogen-rich cytoplasm.


Degeneration and Atrophy

description: A finding that generally has features of degeneration and atrophy.


name: Cytoplasmic Membrane-Bound Granules Present


EBV-Positive Neoplastic Cells Present

description: An immunophenotypic finding indicating that Epstein-Barr virus has been detected in a sample of neoplastic cells.


Glomeruloid Vessels Present

description: A morphologic finding that refers to microvascular proliferation that resembles glomeruloid structures.  It is seen in gliomas.


Crown-Like Structures of the Breast

description: An ultrastructural finding in breast adipose tissue that indicates macrophage infiltration to sites of adipocyte necrosis. This finding is associated with obesity and breast tissue inflammation and may be an indicator for increased risk of neoplastic breast disease.


Comedo Necrosis

description: A morphologic finding that indicates the presence of a cancerous tumor with a central area that contains necrotic cancer cells.


name: Karyocytomegaly and Multinucleated Hepatocytes

description: A finding of both karyocytomegaly and multinucleated hepatocytes in the same lesion.


advanced hepatic fibrosis

description: Septal or bridging fibrosis that results in the disruption of normal blood flow and liver function, and extends across hepatic lobules with significant porto-portal or porto-central bridging. Progression may lead to the formation of nodules that distort the liver architecture, which is termed cirrhosis.


name: Estrogen Receptor Positive by Immunohistochemistry Less than 1 Percent

description: An immunohistochemical staining finding indicating that less than 1 percent of the cells in a tissue sample are expressing estrogen receptor.


name: Estrogen Receptor Positive by Immunohistochemistry 1-10 Percent

description: An immunohistochemical staining finding indicating that 1-10 percent of the cells in a tissue sample are expressing estrogen receptor.


p16-Positive Neoplastic Cells Present

description: An immunohistochemical test result indicating that there are neoplastic cells stained positive with the p16 INK4a monoclonal antibody.


Darkly Pigmented Melanophages Present

description: A morphologic finding indicating the presence of darkly stained macrophages that contain melanin.


Metastasis Present in Distant Organ

description: An indication that cancer cells have migrated and spread to one or more organs that are distant from the primary tumor site.


Infiltrative Growth Pattern

description: A microscopic finding indicating that the neoplastic cells exhibit an infiltrating growth in a tumor sample.


Well Differentiated Lesion

description: A lesion composed of cells that exhibit well differentiated features.


Keratinizing Dysplasia

description: Epithelial dysplasia in which the dysplastic changes, although limited to the lower basal zone, are so severe, that there is a high probability of progression to invasive carcinoma.


Minimally Invasive Lesion

description: A lesion in which the neoplastic epithelial cells invade into but not through the capsule that surround the neoplasm, or invade the entire thickness of the capsule, or invade vessels surrounding the capsule.  Unlike widely invasive lesions, the minimally invasive lesions cannot be recognized as carcinomas on clinical and surgical grounds.  The diagnosis can only be established microscopically.


name: Aggregates of Poorly Differentiated Neuroepithelial Cells Present


Chronic Inflammatory Infiltrate

description: A morphologic finding indicating the presence of reactive lymphocytes, lymphoplasmacytic cells, and/or reactive plasma cells in a tissue sample.


name: Ki-67 Positive Cells Greater than 50 Percent

description: A semi-quantitative microscopic finding indicating that greater than 50 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Diffuse Pattern

description: A morphologic architectural pattern in which a cellular population is distributed in a relatively uniform fashion throughout a specified tissue area; not focal.


Tubular Pattern

description: A morphological appearance characteristic of neoplasms which arise from the glandular or ductal (or both) epithelium, consisting of glandular or ductal neoplastic proliferations forming small tubules with a lumen lined by neoplastic cells.


name: Intracytoplasmic and Extracytoplasmic Eosinophilic Material Present


Dirty Necrosis

description: A morphologic finding indicating the presence of necrotic epithelial cells, neutrophils, karyorrhectic debris, and fibrin in the lumen of malignant glands. It was initially described in colonic adenocarcinomas, but it has also been observed in adenocarcinomas that arise in other anatomic sites, including lungs and ovaries.


name: Dense Intercellular Reticulin Network Present


Atypical Mitotic Figures

description: A morphologic finding indicating the presence of atypical mitoses in malignant cells.


CD56-Positive Neoplastic Cells Present

description: An immunophenotypic finding indicating the presence of neoplastic cells expressing CD56.


name: Spindle Cell Metaplasia of Malignant Cells Present


Capsular Invasion

description: A microscopic finding indicating the infiltration of the capsule that surrounds an organ by a malignant cellular population.


name: Malignant Epithelial Cells with Abundant Cytoplasmic Neutral Lipids Present


name: Estrogen Receptor Positive by Immunohistochemistry 71-80 Percent

description: An immunohistochemical staining finding indicating that 71-80 percent of the cells in a tissue sample are expressing estrogen receptor.


name: Tubular Structures of Glycogen-Rich Non-Ciliated Cells Present


name: Schwannian Stroma Predominant Component of the Tumor Volume


Infiltrative Tumor Margin

description: Describes a tumor border that is invading the adjacent tissue.


name: Histological Subtype Different, Other Pathology Review

description: Pathology analysis not related to the pathologic prescreen review determined a specific histological subtype that is different from the original pathology report.


name: Vascular Channel Formation with Muscular Walls


Ki-67 Positive Cells 20 Percent or Less

description: A semi-quantitative microscopic finding indicating that 20 percent or less of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


name: Progesterone Receptor Positive by Immunohistochemistry 41-50 Percent

description: An immunohistochemical staining finding indicating that 41-50 percent of the cells in a tissue sample are expressing progesterone receptor.


Activated PI3K-Positive Cells Present

description: An indication that cells expressing the active form of a phosphatidylinositol 3-kinase (PI3K) family protein has been detected in a sample.


name: NECTIN4 Expression by Immunohistochemistry 2+

description: An indication that the immunohistochemical staining intensity detected in a sample for NECTIN4 was 2+.


Lobular Cancerization

description: Lobular Cancerization (or cancerization of lobules, COL) is the presence in a lobule of ductal carcinoma in situ (DCIS) tumor cells with preservation of the normal lobular pattern. It appears to represents a variation in the growth pattern of DCIS, not secondary extension of DCIS into a lobule.


Cytoplasmic Alteration

description: A microscopic finding indicating the presence of intracytoplasmic changes in reactive, atypical, dysplastic, or neoplastic cells.


Cohesive Pattern

description: A microscopic finding that the cells in the sample are tightly adhered to one another and distributed uniformly.


Black Discoloration

description: A color change to black.


Intimal proliferation

description: Thickening of the tunica intima of a blood vessel due to injury.


name: Progesterone Receptor Positive by Immunohistochemistry 31-40 Percent

description: An immunohistochemical staining finding indicating that 31-40 percent of the cells in a tissue sample are expressing progesterone receptor.


Chicken-Wire Vasculature

description: A morphologic finding that refers to delicate vascular channel formations.  It is characterized by the formation of arborizing and curving capillaries.


Cervical Transitional Metaplasia

description: Cervical metaplasia in which the cervical squamous epithelium resembles benign urothelium as a result of a lack of cellular maturation.


Vaginal Transitional Cell Metaplasia

description: Vaginal metaplasia in which the vaginal surface squamous epithelium resembles benign transitional urothelium.


name: High Grade Non Cartilaginous Sarcomatous Stroma Present


Micrometastasis 0.2 mm to 2.0 mm

description: A finding of a micrometastasis measuring from 0. 2mm to 2 mm along the greatest dimension.


Basal Cells with Pale Cytoplasm Present

description: A morphologic finding indicating the presence of basal cells in the epidermis with pale or clear-appearing cytoplasm.


Cholesterol Cleft

description: A finding of an empty space in a histological section of paraffin-embedded tissue created by the dissolution of cholesterol crystals.


Sinus Histiocytosis

description: A morphologic finding indicating the presence of histiocytic infiltrates within distended lymph node sinuses.


name: PD-L1 Tumor Proportion Score Greater than or Equal to 50

description: A semi-quantitative finding indicating that at least 50 percent of the viable tumor cells in a sample are positive for PD-L1 expression by immunostaining.


Intramucosal Eosinophils Present

description: A morphologic finding indicating the presence of eosinophils within the mucosa.


Persistent Neuroblastic Cells

description: A morphologic finding indicating the continuing presence of neuroblastic cells in a set of tissue samples collected over time.


name: Columnar Cells With Differentiation to Chief Cells and Parietal Cells Present

description: A morphologic finding indicating the presence of columnar cells with differentiation to chief cells and parietal cells in a gastric tissue sample.


name: Ki-67 Positive Cells Less than or Equal to 50 Percent

description: A semi-quantitative microscopic finding indicating that at most 50 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Oral Epithelial Dysplasia

description: A morphologic finding of dysplastic epithelial cells in the oral cavity.


name: Intermediate Grade Neuroendocrine Lesion

description: A neoplastic lesion with neuroendocrine differentiation and histological features of intermediate grade.


name: Concentric Fibrosis of Intrahepatic Duct

description: A morphologic finding indicating the presence of fibrosis around an intrahepatic bile duct in the liver tissue.


name: Invasive Focus of Carcinoma Cells Measuring 1 mm or Less Present

description: A morphologic finding indicating the presence of an invasive component of carcinoma cells that measures 1 mm or less in greatest dimension.


Uninterrupted Margin

description: An indication that a uniform margin was obtained around the entire excised lesion.


D2C7 2+ Staining

description: A finding of 2+ staining with D2C7 monoclonal antibody in a sample.


name: Nests of Nevus Cells Resembling Nerve Bundles Present


Increased Tingible Body Macrophages

description: Increase in the amount of tingible body macrophages.


Hemorrhagic Change

description: A morphologic finding indicating a change in a tissue due to vascular injury or leakage.


name: Mixture of Germ Cell Neoplastic Components Present

description: A  finding indicating the presence of at least two morphologic components in a germ cell tumor sample.


Low Grade Neuroendocrine Lesion

description: A neoplastic lesion with neuroendocrine differentiation and histological features of low grade.


name: Paracortical Involvement with Residual Follicles Present


Suspicious for Malignancy

description: A microscopic finding indicating the presence of a cellular infiltrate or isolated cells that have features suspicious for malignancy.


Hyaline Droplet Accumulation

description: An increase in eosinophilic cytoplasmic droplets that appear glassy or translucent.


Lymphocytosis

description: A finding indicating the presence of a non-neoplastic or neoplastic proliferation of lymphocytes in the peripheral blood, effusions, or bone marrow.


Basophilic Hypertrophic Focus

description: A central point or locus characterized by hypertrophy and basophilia.


D2C7 1+ Staining

description: A finding of 1+ staining with D2C7 monoclonal antibody in a sample.


name: Greater than or Equal to 10 Mitoses per 10 HPF

description: A microscopic finding indicating the presence of at least ten mitotic figures per ten high power fields in a sample.


Microsatellitosis

description: One or more discontinuous nests of melanoma cells measuring at least 0.3 mm in diameter and separated from the primary lesion by more than 0.05 mm of normal tissue.


Submucosal Invasion Depth

description: A morphological finding indicating the depth of tumor invasion into the submucosal tissue.


name: Delicate Arborizing Vascular Channel Formation


Focal Cortical Dysplasia Type 3

description: Focal cortical dysplasia characterized by different cortical dyslamination and cytological abnormalities with the main lesions located in the same area. It includes the following: type IIIa with architectural distortion of cortical layer in temporal lobe with hippocampal atrophy; type IIIb with architectural distortion of cortical layer adjacent to glial or glioneuronal tumor; type IIIc with architectural distortion of cortical layer adjacent to vascular malformation; and type IIId with architectural distortion of cortical layer adjacent to other lesions acquired in early childhood (e.g., trauma, ischemic event, and encephalitis).


name: Proliferation of High Endothelial Venules Present


D2C7 Staining Finding

description: The results of staining with D2C7 monoclonal antibody in a sample.


name: Contained Diffuse Intrinsic Pontine Glioma Morphology Imaging Finding

description: Not circumscribed, limited within a certain area.


name: Scattered Collections of Differentiating Neuroblasts Present


name: Islands of Odontogenic Epithelium Present


name: Apple Green Dichromism Present in Polarized Congo-Red Stained Sections


Lymph Node Intrasinusoidal Erythrocytes

description: The presence of red blood cells within lymph node sinuses.


Normal Immune Presence

description: Less than 10 percent of the tissue surface area is occupied by immune cell infiltration.


Decidual Reaction

description: The cellular and vascular changes occurring in the endometrium at the time of implantation.


Immune Presence

description: Describes the percent of a tissue's surface area occupied by immune cell infiltration.


CD7-Positive Neoplastic Cells Present

description: An indication that expression of CD7 has been detected in a sample of neoplastic cells.


Dental Calculus

description: Mineralized deposit that forms on the teeth or dental prostheses.


CD23-Positive Neoplastic Cells Present

description: An immunophenotypic finding indicating that expression of CD23 has been detected in a sample of neoplastic cells.


name: Confluent Sheets of Anaplastic T-Lymphocytes Present


Islands of Neuropil-Like Matrix Present

description: A morphologic finding indicating the presence of foci of neuropil-like matrix that are immunostained positive for synaptophysin in infiltrating astrocytomas.


Stromal Hemosiderin Deposition

description: A morphologic finding indicating the presence of hemosiderin deposits in the stroma of a tissue sample.


Steroid Cell Proliferation

description: A morphologic finding indicating the presence of a cellular infiltrate composed of large polygonal cells with abundant eosinophilic (lipid-poor) or pale and vacuolated (lipid-rich) cytoplasm and round nuclei, with a prominent nucleolus.


name: Presence of Extravascular Matrix Patterns

description: A microscopic finding indicating the presence of patterns formed by malignant cells outside the blood vessel circulation in uveal melanoma.  The patterns are detectable using PAS stain without counterstaining with hematoxylin.


Morular Metaplasia of the Endometrium

description: A morphologic finding indicating the replacement of part of the glandular endometrial epithelium by nodular structures that contain non-keratinizing squamous cells.


name: Mixed Neoplastic Epithelial Cell Population

description: A morphologic finding indicating the presence of a mixed population of neoplastic epithelial cells in a tumor sample.


name: Absence of Invasion of the Muscularis Externa


Growth Phase

description: The morphologic architectural pattern in which the tumor cells spread.


name: Estrogen Receptor Positive by Immunohistochemistry 51-60 Percent

description: An immunohistochemical staining finding indicating that 51-60 percent of the cells in a tissue sample are expressing estrogen receptor.


Entrapped White Matter Present

description: A morphologic finding that refers to the presence of ectopic white matter in a tissue sample.


name: Neuroendocrine and Non-Neuroendocrine Neoplastic Components Present

description: A microscopic finding indicating the presence of two cellular neoplastic components, neuroendocrine and non-neuroendocrine, in a tissue sample.


Lack of Expression of PD-L1

description: An immunohistochemical test result that indicates lack of expression of PD-L1 in a tissue sample of a primary or metastatic malignant neoplasm.


name: Proliferation of Squamous Nests with Little Stromal Reaction


Gastric-Type Epithelial Differentiation

description: A morphologic finding indicating the presence of gastric epithelial cell differentiation in a tissue sample.


Renal Cell Dysplasia

description: A finding of congenital malformations in the kidney characterized by the presence of cysts of various sizes, primitive ducts, islands of metaplastic cartilage and undifferentiated mesenchyme, and the absence of cortico-medullary demarcation.


Isolated Tumor Cells Less than 0.2 mm

description: A cluster of metastatic malignant cells measuring less than 0.2 mm along the greatest dimension.


name: PD-L1 Tumor Proportion Score Greater than or Equal to 1

description: A semi-quantitative finding indicating that at least 1 percent of the viable tumor cells in a sample are positive for PD-L1 expression by immunostaining.


Chronic lymphocytic inflammation

description: A morphologic finding referring to the presence of a cellular infiltrate that is composed of non-neoplastic or neoplastic lymphocytes in a tissue sample.


Full-Thickness Epidermal Atypia

description: A morphologic finding indicating the presence of keratinocyte atypia involving the full thickness of epidermis.


Ovarian Capsule Ruptured

description: A microscopy finding indicating that a portion of the ovarian capsule in a biopsy has ruptured.


Morphologic Finding

description: A light microscopic finding that describes the cellular characteristics and architectural patterns of cell populations in a tissue sample.


Isolated Tumor Cells

description: The presence of single tumor cells or tiny clusters of tumor cells in a pathologic specimen.


Nodule External Feature

description: A characteristic associated with a nodule that is found in the surrounding environment.


name: Cellular Changes Resembling Foveolar Epithelium Cells

description: A morphologic finding indicating the presence of cells that resemble gastric foveolar epithelial cells.


name: Immunoglobulin Heavy Chain Class Switch Associated with Immunoglobulin G4 Expression in Neoplastic Cells

description: A finding indicating the presence of neoplastic cells expressing immunoglobulin heavy chain class switch associated with expression of immunoglobulin G4.


name: PD-L1 Combined Positive Score Greater than or Equal to 20

description: A semi-quantitative immunohistochemical finding indicating that the number of all PD-L1-expressing cells divided by the total number of viable tumor cells in a sample multiplied by 100 is at least 20.


name: Mixture of Embryonal and Alveolar Features Present

description: A morphologic finding indicating the presence of a mixture of embryonal and alveolar components in a rhabdomyosarcoma.


name: Neoplastic Glandular Epithelium Resembling the Normal Endometrium Present


Necrosis Negative

description: An indication that signs of necrosis were not found in a sample.


Kidney Fibrosis

description: Excessive intraglomerular or interstitial accumulation of extracellular matrix proteins in the kidney, leading to the destruction of adjacent cellular structures and nephron loss.


Hyperplasia and Metaplasia

description: A finding of both hyperplastic and metaplastic changes in a pathologic process.


Poorly Formed Pattern

description: A morphologic finding indicating the presence of a malignant cellular infiltrate with poorly defined glands in a tissue sample.


name: Calcitonin Positive Neoplastic Cells Present


Small Aggregates of Tumor Cells Present

description: A morphologic finding indicating the presence of small aggregates of tumor cells in a tissue sample.


Hyalinized Stroma Formation

description: Replacement of tissue stromal elements by hyaline material.


name: Polarization of Nuclei Towards the Glandular Lumen


Dilated Cystic Spaces Present

description: A morphologic finding indicating the presence of dilated cystic spaces in the stroma of a neoplasm.


Squamous Metaplasia of Bronchial Mucosa

description: Replacement of the bronchial glandular epithelial cells by squamous cells.


Unspecified Atypical Cells Present

description: A finding indicating that abnormal cells with indeterminate morphological features are present in a sample.


MSH2 Nuclear Expression Intact

description: An indication that expression of MSH2 was detected in the nuclei of cells in a sample.


Papillary Growth Pattern

description: A morphologic finding indicating the presence of a cellular infiltrate with papillary growth in a tissue sample.


Osseous Component Present

description: A morphologic finding indicating the presence of bone elements in a tissue sample.


Columnar Metaplasia

description: A morphologic finding indicating the transformation of non-columnar epithelial cells into columnar cells.


name: Tumor Invasion of the Prostatic Ducts and Acini

description: A morphologic finding indicating the presence of a malignant cellular infiltrate invading the ductal and acinar structures of the prostate gland.


Perivascular Satellitosis

description: A morphologic finding that refers to the accumulation of glial cells encircling vessels in a tissue specimen.


name: PD-L1 Tumor Proportion Score Less than 1

description: A semi-quantitative finding indicating that less than 1 percent of the viable tumor cells in a sample are positive for PD-L1 expression by immunostaining.


Subepithelial Collagen Band Present

description: A morphologic finding indicating the presence of a collagen band under the epithelial layer in a tissue sample.


name: Chromogranin-A Positive Neoplastic Cells Present

description: An immunophenotypic test result indicating positive staining of neoplastic cells for chromogranin A.


name: Area of Depigmentation at the Periphery of the Dermal Melanocytic Infiltrate Present


Dystrophic Calcification

description: Calcium deposits in  degenerated or necrotic tissue without abnormalities in blood calcium.


Morphologic Architectural Pattern

description: A microscopic finding that relates to the architectural patterns of a normal or abnormal cellular population in a tissue specimen.


Mouth Necrotic Lesion

description: A necrotic process affecting the tissues of the mouth.


Calcium Oxalate Crystal Deposition

description: A finding indicating the formation of calcium oxalate crystal deposits in an organ.


Radial Growth Phase

description: A morphologic architectural pattern in which the tumor cells spread horizontally.


Submucosal 2 Invasion

description: Submucosal tumor invasion into the middle third of the submucosal tissue.


name: Melanin-Forming Neuroepithelial Cells Present


name: Poorly Cohesive Malignant Cellular Infiltrate

description: A morphologic finding indicating the presence of a malignant cellular infiltrate characterized by the presence of individual cells and/or tiny cellular aggregates.


name: Progesterone Receptor Positive by Immunohistochemistry 51-60 Percent

description: An immunohistochemical staining finding indicating that 51-60 percent of the cells in a tissue sample are expressing progesterone receptor.


name: HMB-45-Positive Neoplastic Cells Present

description: An immunohistochemical finding that the monoclonal antibody HMB-45 binds to a sample of neoplastic cells.


Intrahepatocellular Erythrocytes

description: The presence of red blood cells within hepatocytes of the liver parenchyma.


name: Differentiating Neuroblasts More than 5 Percent of the Tumor Cells


name: HLA-DR-Negative Neoplastic Cells Present

description: An immunophenotypic finding indicating the presence of neoplastic cells negative for HLA-DR expression.


Nearly Full-Thickness Epidermal Atypia

description: A morphologic finding indicating the presence of keratinocyte atypia involving nearly the full thickness of epidermis.


name: Gastrin-Positive Neoplastic Cells Present


name: Hurthle cell metaplasia of thyroid gland

description: A morphologic finding indicating transformation of follicular cells to large cells with abundant eosinophilic and granular cytoplasm (Hurthle cells) in the thyroid gland.


name: Malignant Cells with Uniform Nuclei Present

description: A morphologic finding indicating the presence of malignant cells with uniform nuclei in a tissue sample.


name: Anastomosing Strands of Tumor Cells Present


name: Ki-67 Positive Cells Greater than or Equal to 5 Percent

description: A semi-quantitative microscopic finding indicating that at least 5 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Intraductal Lesion

description: A morphologic finding indicating the presence of a benign, atypical, or malignant cellular proliferation within the ducts in a tissue sample.


name: Loss of Immunohistochemical Expression of Succinate Dehydrogenase (SDH) B

description: An immunohistochemical test result indicating the loss of expression of succinate dehydrogenase (SDH) B in the neoplastic cells of a tumor sample.


Increased Thymic Epithelium-Free Areas

description: Increase in the amount of epithelium-free areas in the thymic cortex.


Hyperplasia and Hyperkeratosis

description: A finding that generally has features of hyperplasia and hyperkeratosis.


Apocrine metaplasia of breast

description: A morphologic finding indicating the transformation of the epithelial cells in a breast tissue sample to cells with abundant eosinophilic cytoplasm.


Vascular Invasion Negative

description: An indication that signs of vascular invasion have not been found in a sample.


Mixed Cellular Population

description: A morphologic finding indicating the presence of a cellular infiltrate with a mixed population of cells in a tissue sample.


Ovarian Capsule Intact

description: A microscopy finding indicating that the ovarian capsule in a biopsy is intact.


Estrogen Receptor Status 3+

description: An immunohistochemical result of 3 for estrogen receptor expression that is considered positive for expression.


Focal Extracapsular Extention

description: A morphological finding indicating that the tumor cell invasion outside the lymph node capsule was less than or equal to 1 mm.


name: Melanin-Pigmented Epithelioid Cells Present

description: A morphologic finding indicating the presence of melanin-pigmented epithelioid cells in a tumor sample.


Basophilic Focus

description: A group of cells that exhibit some type of cytologic alteration resulting in basophilia, and that are confined to a specific area of the sample.


Non-Keratinizing Dysplasia

description: Intraepithelial proliferation of dysplastic epithelial cells not associated with keratin formation.


Intestinal Necrotic Lesion

description: A necrotic process involving the intestinal wall.


name: Estrogen Receptor Positive by Immunohistochemistry Less than or Equal to 9 Percent

description: An immunohistochemical staining finding indicating that at most 9 percent of the cells in a tissue sample are expressing estrogen receptor.


name: p16 Immunohistochemistry or HPV Testing Status Unknown

description: A finding indicating that there is no information regarding the p16 immunohistochemistry or HPV testing status in a tumor sample.


name: Largest Diameter of Extrapelvic Peritoneal Metastasis

description: The largest diameter found for any extrapelvic peritoneal metastases in a subject.


name: Dilated Thin-Walled Vascular Space Formation


name: Progesterone Receptor Positive by Immunohistochemistry 1-9 Percent

description: An immunohistochemical staining finding indicating that between 1 and 9 percent of the cells in a tissue sample are expressing progesterone receptor.


Glandular metaplasia

description: A morphologic finding indicating the alteration of the squamous or transitional epithelial cells to glandular cells.


EPCAM Loss of Nuclear Expression

description: An indication that expression of EPCAM was not detected in the nuclei of cells in a sample.


name: PD-L1 Expression Greater than or Equal to 1 Percent

description: An immunohistochemical finding indicating that at least 1 percent of the cells in a sample are expressing PD-L1.


Tumor Invasion of the Prostatic Urethra

description: A morphologic finding indicating the presence of malignant cells infiltrating the portion of the urethra that passes through the prostate gland.


name: Presence of Clear Cytoplasm Less than or Equal to 25 Percent

description: A finding indicating that less than or equal to 25 percent of the cells in a sample have clear or vacuolated cytoplasm.


Dilatation and Diverticulum

description: A finding indicating the presence of dilatation and diverticulum in a tubular anatomic structure.


Mammary Gland Type Features Present

description: A microscopic finding indicating the presence of mammary gland type morphological features in a tumor sample.


Nuclear Expression Intact

description: An indication that expression of a nuclear factor is detected in the nuclei of cells in a sample.


Cellular infiltrate

description: A morphological finding where an influx of cells is detected in locations or numbers that those cells are not normally found.


name: Concentric Perivascular Arrangement of Tumor Cells


TACSTD2 Status by Immunohistochemistry

description: An indication that expression or absence of TACSTD2 in a sample was determined using immunohistochemical staining techniques.


Cellular Granularity Present

description: A morphologic finding indicating the presence of prominent cellular granularity in a tissue sample.


Metastasis Negative

description: An indication that signs of metastasis were not found in a sample.


Thyroid Dysplasia

description: A transformation of the cells of the thyroid characterized by enlarged follicular cells, apically displaced nuclei, and large intracellular vacuole with homogeneous eosinophilic content located at the base of follicular epithelial cells. (INHAND)


name: Mixed Neoplastic Glandular and Squamous Cell Population


CSF Leukocytes Present

description: An indication that leukocytes were found in a cerebrospinal fluid sample.


name: Peribronchial Proliferation of Neoplastic Cells Present

description: A morphologic finding indicating the proliferation of neoplastic cells around bronchi in the lung parenchyma.


name: Mitotic Rate Greater than or Equal to One per Square Millimeter

description: A result of a mitotic rate equal to or greater than one per square millimeter.


name: Predominantly Fibroglandular Breast Tissue

description: A finding indicating that the predominant components in a breast tissue sample are fibrous and glandular elements.


name: Microcalcification Present in Neoplastic and Non-Neoplastic Tissue

description: A finding of microcalcifications located within neoplastic tissue, and in tissues without neoplasm.


name: Tissues Derived from Two or Three Embryonic Layers Present


Benign Cellular Infiltrate

description: A morphologic finding indicating the presence of a cellular infiltrate without atypia in a tumor sample.


name: Malignant Glandular Epithelium Resembling the Endocervical Epithelium Present


Sarcomatoid Features

description: A microscopic finding indicating the presence of cells with sarcomatoid, usually spindle cell differentiation in a tumor sample.


name: Abundant Intracytoplasmic Lipofuscin Present


MLH1 Loss of Nuclear Expression

description: An indication that expression of MLH1 was not detected in the nuclei of cells in a sample.


Widely Invasive Lesion

description: A lesion composed of tumor cells invading a wide area beyond the immediately surrounding tissues.


Borderline Lesion

description: A lesion characterized by the presence of atypical or low-grade neoplastic cells, which may or may not exhibit stromal microinvasion and cannot be qualified as completely malignant.


name: Excellent Tissue Fixation with Well Preserved Nuclear Details


Immunophenotypic Finding

description: A histologic finding related to the antigen profile detected in a cell or tissue sample.


Hemosiderin in Decidua Parietalis

description: The deposition of hemosiderin along the gravid uterine wall.


name: Poorly Organized and Inadequately Mineralized Bone Present

description: A morphologic finding indicating the presence of poorly organized and inadequately mineralized bone in a tissue sample.


Mucosal Lesion

description: A pathologic process that affects the mucosa.


Tubule Formation

description: The presence of malignant tubular formations which are thought to represent malignant counterparts of the terminal ductal-lobular units of the breast.


name: PD-L1 Expression Greater than or Equal to 50 Percent

description: An immunohistochemical finding indicating that at least 50 percent of the cells in a sample are expressing PD-L1.


name: Zona Fasciculata-Resembling Cells are Less Than or Equal to Twenty Five Percent

description: A morphologic finding indicating the presence of less than or equal to twenty five percent of clear or vacuolated cells that resemble the normal zona fasciculata in adrenocortical tumors.


Eccentric Morphology

description: The center of the tumor lies off-midline.


name: PD-L1 Expression Less than or Equal to 50 Percent

description: An immunohistochemical finding indicating that at most 50 percent of the cells in a sample are expressing PD-L1.


name: Capillary Sized Vascular Channel Formation


Degeneration and Necrosis

description: A finding that generally has features of degeneration and necrosis.


Malignant Lesion

description: A lesion characterized by the presence of a malignant cellular population.


name: Intracytoplasmic Mucin Present in More Than 50% of Malignant Cells

description: A morphologic finding indicating the presence of intracytoplasmic mucin in more than 50% of malignant cells in a tumor sample.


Gland Loss

description: A morphologic finding indicating the partial or complete loss of a gland structure.


name: Grossly Negative and Microscopically Negative Surgical Margin

description: The absence of tumor cells at the edge of a surgically excised specimen, both macroscopically and microscopically.


Loss of Nuclear Expression

description: An indication that expression of a nuclear factor is not detected in the nuclei of cells in a sample.


Limited to brainstem

description: The area of interest is confined to the brainstem.


Staining Intensity 4+

description: A measurement of the amount or proportion of tissue or cells that have a staining intensity of 4+.


name: Small, Stellate, or Spindled Cells Present

description: A morphologic finding indicating the presence of small, stellate, or spindled cells in a cellular infiltrate.


Reactive Lymphocytosis

description: A finding indicating the presence of an increased number of non-neoplastic lymphocytes in the peripheral blood, effusions, or bone marrow.


name: Estrogen Receptor Positive by Immunohistochemistry 91-100 Percent

description: An immunohistochemical staining finding indicating that 91-100 percent of the cells in a tissue sample are expressing estrogen receptor.


name: Estrogen Receptor Positive by Immunohistochemistry

description: An immunohistochemical staining finding indicating that cells in a tissue sample are expressing estrogen receptor.


Lymphatic Invasion

description: A term referring to the presence of tumor emboli or tumor masses within lymphatic vessels.


name: Progesterone Receptor Positive by Immunohistochemistry Less than 20 Percent

description: An immunohistochemical staining finding indicating that less than 20 percent of the cells in a tissue sample are expressing progesterone receptor.


Absence of Bone Marrow Dysplasia

description: An indication that signs of dysplasia were not detected in a bone marrow sample


name: Percent Follicular Component Less than or Equal to 10 Percent

description: A semi-quantitative microscopic finding indicating that less than or equal to 10 percent of the area of a tissue section has follicular structures.


Margin Uninvolved by Invasive Melanoma

description: A result that the margin is uninvolved by invasive melanoma.


Schiller-Duval Body

description: A morphologic finding that refers to a structure that consists of a central vessel surrounded by tumor cells. This cell-vessel structure is contained in a cystic space. It is found in approximately 50% of yolk sac tumors.


PD-L1 Combined Positive Score

description: A measurement of PD-L1 expression in a tumor sample, calculated as the number of PD-L1 staining cells (tumor cells, lymphocytes, macrophages) divided by the total number of viable tumor cells, multiplied by 100.


Hypercellularity

description: An increase in the number of cells in an organ or tissue.


Mesenchymal Metaplasia

description: A morphologic finding that refers to the transformation or replacement of a group of non-mesenchymal cells into osseous, cartilagenous, or lipomatous cells.


Sarcomatous Component Present

description: A histopathologic finding characterized by the presence of malignant cells of connective tissue origin in a tumor sample.  Examples of connective tissue cells that can undergo malignant transformation include smooth and skeletal muscle cells, adipose tissue cells, osteocytes, and chondrocytes.


NECTIN4 Status by Immunohistochemistry

description: An indication that expression or absence of NECTIN4 in a sample was determined using immunohistochemical staining techniques.


PD-L1 Combined Positive Score 20

description: A quantitative immunohistochemical finding indicating that the number of all PD-L1-expressing cells divided by the total number of viable tumor cells in a sample multiplied by 100 is 20.


name: Intra or Intercytoplasmic Lumina Present

description: A morphologic finding where the malignant cell has intra or intercytoplasmic lumina thereby imparting a cribriform or sieve-like architecture.


Gland Branching

description: An architectural morphologic finding indicating branching of glands as a result of a pathologic process.


name: PD-L1 Combined Positive Score Less than 20

description: A semi-quantitative immunohistochemical finding indicating that the number of all PD-L1-expressing cells divided by the total number of viable tumor cells in a sample multiplied by 100 is less than 20.


Extracellular Mucin Present

description: A morphologic finding indicating the presence of extracellular mucin in a tumor sample.


Epithelium Attenuation

description: Flattening or spreading out of epithelial cells to cover spatial defects.


Abrupt Nuclear Anaplasia

description: A morphologic finding indicating the presence of small clusters of tumor cells with marked nuclear anaplasia in a background of tumor cells with bland nuclear cytology.


name: Microcalcification Present in Neoplastic Tissue

description: A finding of microcalcifications located within neoplastic tissue.


name: Intestinal Metaplasia of Esophageal Mucosa

description: A finding indicating the replacement of part of the esophageal mucosal epithelium by intestinal-type epithelium.


Necrosis of pancreas

description: A necrotic process affecting the pancreas.


Head soft tissue necrosis

description: A necrotic process affecting the soft tissues of the head.


Divergent Differentiation

description: A microscopic finding indicating that a tumor exhibits more than one line of histologic differentiation.


Prominent Stromal Reaction

description: A morphologic finding indicating the presence of an exuberant proliferation of fibroblasts and myofibroblasts in the stroma of a tumor sample.


name: Scattered Neuroendocrine Cells by Immunohistochemistry Present

description: A morphologic finding indicating the presence of scattered neuroendocrine cells by immunohistochemistry in a cellular infiltrate.


Lamellar Pattern

description: Having an appearance of thin plate-like structures.


Tubuloglandular Pattern

description: A morphologic finding indicating the presence of a tubuloglandular growth pattern in a cellular infiltrate.


Non-Cohesive Pattern

description: A microscopic finding where the cells in a sample are arranged, singly or in small clusters, demonstrate loose adhesion with one another and may not be distributed uniformly.


Largest Dimension of Residual Neoplasm

description: The largest single dimension of the residual tumor after surgical resection.


Prostatectomy Margin Status

description: The determination of the presence of actual or potential neoplastic tissue proximal to the prostatectomy specimen.


Nucleated Red Blood Cells Present

description: A morphologic finding indicating the presence of nucleated red cells in the peripheral blood.


Bridging fibrosis

description: A morphologic finding indicating the presence of fibrous bands connecting portal tracts, portal tracts and centrilobular spaces, or centrilobular spaces in a liver tissue sample in a patient with evolving cirrhosis.


name: Immunoglobulin Heavy Chain Class Switch Positive Neoplastic Cells

description: A finding indicating the presence of neoplastic cells expressing immunoglobulin heavy chain class switch.


Mallory Bodies Present

description: A morphologic finding indicating the presence of Mallory bodies in the liver parenchyma.  Mallory bodies are eosinophilic cytoplasmic inclusions in the hepatocytes.  They contain filaments and are present in the liver parenchyma of patients with various liver disorders including alcoholic liver disease, Wilson disease, and primary biliary cirrhosis.


Loops Forming Networks

description: A microscopic finding indicating the presence or absence of loops forming networks in uveal melanoma.


Muscle Cell Hypertrophy

description: A morphologic finding indicating the presence of enlarged muscle cells in a muscle tissue sample.


name: Vacuolated Plasma Cells in the Bone Marrow


Rectal Necrotic Lesion

description: A necrotic process involving the rectal wall.


Atypia suspicious for malignancy

description: A microscopic finding indicating the presence of an atypical neoplastic cellular infiltrate with cytologic characteristics and/or architectural patterns that are not diagnostic, but raise the possibility of malignancy.


Viral Inclusions Present

description: A morphologic finding indicating the presence of nuclear or cytoplasmic viral inclusion bodies.


Abnormal Tissue Present

description: A morphologic finding indicating the presence of an abnormal or aberrant cellular component in an organ sample.


Squamous metaplasia

description: A morphologic finding indicating the transformation of glandular or transitional epithelial cells to, usually, mature squamous epithelial cells.  Representative examples include squamous metaplasia of bronchial epithelium, cervix, urinary bladder, and prostate gland.


Crown-Like Structure

description: An ultrastructural finding in adipose tissue that indicates macrophage infiltration to sites of adipocyte necrosis.


TP53 Nuclear Expression Intact

description: An indication that expression of TP53 was detected in the nuclei of cells in a sample.


Staining Intensity 2-3+

description: A measurement of the amount or proportion of tissue or cells that have a staining intensity of 2+ or 3+.


name: Malignant Cells with Nuclei of Various Sizes and Shapes Present

description: A morphologic finding indicating the presence of malignant cells with a range of nuclear sizes and shapes.


Ependymal Differentiation

description: A morphologic finding indicating the presence of neoplastic cells that display ependymal cell features.


Hemosiderin in Decidua Basalis

description: The deposition of hemosiderin along the gravid uterine fundus beneath the placenta.


Paneth Cell-Like Change

description: A morphologic finding indicating the presence of single cells or small groups of cells with prominent eosinophilic cytoplasmic granules in a tissue sample.


Ductal or Ductular Proliferation

description: A morphologic finding indicating the presence of typical or atypical proliferation of biliary epithelial cells in the portal tracts of the liver.


name: Proliferation of Follicular Dendritic Cells Present


Intercellular Bridges Present

description: A microscopic finding indicating the presence of intercellular bridges connecting adjacent cells in a tissue sample.


Dysplasia

description: A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer.


name: Bone Marrow Clonal B-Cell Lymphocytic Infiltrate

description: A finding indicating the presence of a clonal B-cell lymphocytic infiltrate in a bone marrow sample.


Peritoneal Transitional Cell Metaplasia

description: A morphologic finding that refers to the replacement of peritoneal mesothelium with transitional epithelium.


name: Estrogen Receptor Positive by Immunohistochemistry Less than 10 Percent

description: An immunohistochemical staining finding indicating that less than 10 percent of the cells in a tissue sample are expressing estrogen receptor.


Infiltrate and Fibrosis

description: A morphologic finding indicating the presence of a cellular infiltrate associated with fibrosis in a tissue sample.


Loss of Cell Polarity

description: A morphologic finding indicating the loss of polarity and disorganization of cells affected by cancer.


PROCR/PDGFRA/ZEB1 Positive Cells

description: An immunophenotypic finding indicating that simultaneous expression of ZEB1 and cell surface expression of both PROCR and PDGFRA have been detected in a sample of cells. Enriched expression of cells with this phenotype has been observed in normal ductal epithelial breast cells of women of African ancestry as compared to those of European ancestry.


Small Intestinal Necrotic Lesion

description: A necrotic process involving the wall of the small intestine.


name: Oligodendroglioma-Like Component with Perinuclear Cytoplasmic Halos Present

description: A morphologic finding referring to the presence of a cellular infiltrate that is composed of cells with perinuclear cytoplasmic halos, resembling oligodendrocytes.


Dedifferentiated Malignant Infiltrate

description: A morphologic finding indicating the presence of a high grade undifferentiated malignant cellular infiltrate and a second component of a low grade malignant cellular infiltrate in a tissue sample.


Clark Level V

description: A morphologic finding indicating that the cutaneous melanoma has invaded the subcutaneous tissue.


Staining Intensity 1-2+

description: A measurement of the amount or proportion of tissue or cells that have a staining intensity of 1+ or 2+.


Hypertrophy and Hyperplasia

description: A finding of both hypertrophy and hyperplasia in the same lesion.


Staining Intensity 2+

description: A measurement of the amount or proportion of tissue or cells that have a staining intensity of 2+.


name: Exophytic Diffuse Intrinsic Pontine Glioma Morphology Imaging Finding

description: Tumor causes a focal deviation of normal brainstem; CSF boundary (cistern or ventricle) or surrounds basilar artery greater than 180 degrees.


name: Thyroglobulin-Positive Neoplastic Cells Present


Glandular Differentiation

description: A microscopic finding indicating the presence of cells with glandular differentiation in a tumor sample.


name: Atypical Glandular Epithelium Resembling the Normal Endometrium Present


Generalized Dysplasia

description: A morphologic finding indicating the presence of dysplasia throughout a cellular component in a tissue sample.


name: Stratified Columnar Tumor Cells with Intracytoplasmic Mucin Vacuoles Present

description: A morphologic finding indicating the presence of stratified columnar cells with intracytoplasmic mucin-containing vacuoles in a tumor sample.


name: Human Herpesvirus 8-Positive Neoplastic Cells Present

description: An indication that human herpesvirus 8 has been detected in a sample of neoplastic cells.


Intestinal metaplasia

description: A morphologic finding indicating the replacement of epithelial tissue outside the intestines by intestinal-type epithelium.


name: Cytokeratin-Positive Neoplastic Cells Present


name: Ki-67 Positive Cells Greater than or Equal to 15 Percent

description: A semi-quantitative microscopic finding indicating that at least 15 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Sinusoidal Infiltration

description: A microscopic finding indicating the invasion of sinusoidal spaces by malignant cells.


Premalignant Lesion

description: A lesion characterized by the proliferation of atypical or dysplastic cells without evidence of stromal invasion.


Perineuronal Satellitosis

description: A morphologic finding that refers to the accumulation of glial cells encircling neurons in a tissue specimen.


name: Retiform Structures Comprise 90% or More of the Tumor


Chronic Choriodeciduitis

description: Increased parietal decidual lymphocytes invading the fetal chorion and/or amnion.


name: Perimysial and Endomysial Inflammatory Infiltrate

description: A morphologic finding indicating the presence of inflammatory cells in the connective tissue that surrounds groups of muscle fibers (perimysium) and the connective tissue that surrounds individual muscle fibers (endomysium).


Ovarian Capsule Fragmented

description: A microscopy finding indicating that a portion of the ovarian capsule in a biopsy was fragmented.


Increased Osteoclasts

description: An increase in the amount of osteoclasts.


High Grade Oral Epithelial Dysplasia

description: Dysplasia in the oral cavity with high grade architectural and cytological epithelial changes.


Mild dysplasia

description: A morphologic finding indicating the presence of mild cellular atypia associated with mild architectural changes in a tissue sample.


Nested Pattern

description: A microscopic finding indicating that the neoplastic cells are arranged in compact nests in a tumor sample.


Not Limited to Brainstem

description: The area of interest extends outside the brainstem.


name: Neoplastic Cells with Papillary Architecture Present

description: A morphologic finding indicating the presence of a neoplastic cellular infiltrate forming organized papillary architecture in a tumor sample.


ESR1 Status by Immunohistochemistry

description: An indication that expression or absence of ESR1 in a sample was determined using immunohistochemical staining techniques.


Mitotic Figure

description: The microscopic appearance of a cell undergoing mitosis.


CD5-Positive Neoplastic Cells Present

description: An immunophenotypic finding indicating that expression of CD5 has been detected in a sample of neoplastic cells.


Compact Pattern

description: Closely crowded or packed together.


Glomerular Hypertrophy

description: A morphologic finding indicating enlargement of the glomeruli in a kidney specimen.


Intraductal Cellular Proliferation

description: A morphologic finding indicating cellular proliferation within the lumen of ducts.


Increased Apoptosis

description: Increase in the amount of apoptosis.


name: Poorly Differentiated Neuroendocrine Lesion

description: A neoplastic lesion with neuroendocrine differentiation and poorly differentiated histological features.


Fibrosis deep connective tissue

description: Fibrotic degeneration of the deep connective tissues.


name: Immunoglobulin Heavy Chain Class Switch Associated with Immunoglobulin G Expression in Neoplastic Cells

description: A finding indicating the presence of neoplastic cells expressing immunoglobulin heavy chain class switch associated with expression of immunoglobulin G.


PD-L1 Tumor Proportion Score 1-49

description: A semi-quantitative finding indicating that 1-49 percent of the viable tumor cells in a sample are positive for PD-L1 expression by immunostaining.


Arias-Stella Reaction

description: Severe cellular and nuclear atypia in the cells of the endometrial glands. It often occurs during gestation, gestational trophoblastic disease, and treatment with gonadotropins or high doses of progestins.


name: MUC1 with Truncated O-Glycans-Positive Neoplastic Cells Present

description: An indication that a the surfaces of cells in sample have detectable amounts of a glycosylated mucin-1 protein (MUC1) that includes a cancer-specific truncated O-glycan modification.


Ganglioneuroma Component Present

description: A finding indicating the presence of large ganglion cells, neural cellular infiltrates and a stroma with Schwannian differentiation in a neoplastic tissue specimen.


name: PD-L1 Expression Positive in Tumor Infiltrating Immune Cells

description: An immunohistochemical test result indicating that expression of PD-L1 by tumor infiltrating immune cells was detected in a sample.


Pseudopapillary Pattern

description: A morphologic finding indicating the presence of poorly cohesive neoplastic cells arranged around fibrovascular cores in a tissue sample.


name: Decreased Levels of HLA Class I Panel Reactive Antibody

description: A finding indicating a decrease in the amount of HLA class I panel reactive antibodies in a blood or serum sample when compared to a previously collected sample.


Aberrant Craniopharyngeal Structures

description: Proliferation of acinar, tubular, or fusiform cells or structures in the neurohypophysis, or between the pars intermedia and pars nervosa. (INHAND)


Dedifferentiated Lesion

description: A lesion composed of cells that have undergone transformation to less mature forms.


Lobulated Growth Pattern

description: A morphologic finding indicating the presence of a cellular infiltrate forming lobules in a tissue sample.


Nuclear Pleomorphism

description: Having nuclei with various distinct forms.


Mitotic Activity

description: Having to do with the presence of dividing (proliferating) cells. Cancerous tissue generally has more mitotic activity than normal tissues.


Pushing Tumor Margin

description: Describes a tumor border with an expanding and smooth configuration.


name: Small Intestinal Intraepithelial Lymphocytosis


name: Neoplastic Cells with TFH Cell Phenotype Present

description: An immunohistochemical finding indicating the presence of neoplastic lymphocytes manifesting a T follicular helper (TFH) phenotype.


name: Atypia Confined to the Basal and Parabasal Epithelial Layers


HMB45-Positive Cells Present

description: An immunohistochemical finding that the monoclonal antibody HMB-45 binds to a the cells in a biosample.


name: PD-L1 Combined Positive Score Greater than or Equal to 5

description: A semi-quantitative immunohistochemical finding indicating that the number of all PD-L1-expressing cells divided by the total number of viable tumor cells in a sample multiplied by 100 is at least 5.


Transition Zone-Like

description: A morphologic finding indicating the presence of an epithelial infiltrate resembling the cells of the transition zone of the prostate gland.


name: Villous Projections of the Neoplastic Epithelium Present

description: A morphologic finding indicating the presence of prominent, thin, elongated projections of the neoplastic glandular epithelium in the colorectal mucosa.


name: Microcalcification Present in Non-Neoplastic Tissue

description: A finding of microcalcifications located within tissues without neoplasm.


name: Neoplastic Cells with CD38 Dim-to-Negative Expression Present

description: An immunophenotypic finding indicating the presence of neoplastic cells with dim-to-negative CD38 expression.


name: Inconspicuous Syncytiotrophoblastic Cell Component


CSF RBCs Present

description: An indication that erythrocytes were found in the cerebrospinal fluid sample.


name: Clusters and Cords of GFAP Positive Epithelioid Tumor Cells Present


Gastric Necrotic Lesion

description: A necrotic process affecting the gastric wall.


Focus of Cellular Alteration

description: A group of cell that show altered characteristics in comparison to normal cell types and are confined to a specific area of the sample.


Tumor-Associated Lymphocytosis

description: Non-neoplastic lymphocytosis associated with the presence of a tumor.


name: Dilated Thick-Walled Vascular Space Formation


name: Vater-Pacini Corpuscles-Like Structures Present


Extraskeletal calcification

description: Deposition of calcium in tissues outside of bone.


name: Large Neoplastic Glands with Branching and Papillary Infolding Present


name: Malignant Epithelial Cells with Abundant Clear Cytoplasm Containing Glycogen Present


Increased Colloid

description: Increase in the amount of colloid.


Tumor Capsule Invasion Present

description: A morphologic finding indicating that tumor cells have infiltrated the surrounding capsule of connective tissue and invaded nearby tissues.


name: Surface Immunoglobulin-Positive Cells Present

description: A microscopic finding indicating that immunoglobulins are bound to or expressed on the surface of cells in a sample.


Minimal Invasion Present

description: A morphologic finding indicating the infiltration of the stroma immediately adjacent to a carcinoma in situ by isolated malignant cells or small groups of malignant cells.


PD-L1 Expression Less than 1 Percent

description: An immunohistochemical finding indicating that less than 1 percent of the cells in a sample are expressing PD-L1.


name: Chromogranin-Positive Neoplastic Cells Present

description: An indication that expression of one or more chromogranin family proteins has been detected in a sample of neoplastic cells.


Peritoneal Necrotic Lesion

description: A necrotic process affecting the peritoneum.


Crooke Hyaline Change

description: Intracytoplasmic accumulation of cytokeratin.


Margin Uninvolved by Invasive Carcinoma

description: A result that the margin is not uninvolved by invasive carcinoma.


Spindle Cell Metaplasia

description: A morphologic finding indicating the transformation of non-spindle cells to spindle-shaped cells.


name: Neoplastic Cells with Double Expression of MYC and BCL2 Proteins Present

description: An immunohistochemical finding indicating the presence of double expression of MYC and BCL2 proteins in the neoplastic cells of a tumor sample.


name: Nests of Tumor Cell Nuclei in a Fibrillary Matrix


name: Ki-67 Positive Cells Greater than or Equal to 50 Percent

description: A semi-quantitative microscopic finding indicating that at least 50 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Dimpling

description: Having the appearance of an inward pulling.


name: PD-L1 Tumor Proportion Score Greater than or Equal to 5

description: A semi-quantitative finding indicating that at least 5 percent of the viable tumor cells in a sample are positive for PD-L1 expression by immunostaining.


name: Bone Marrow Lymphoplasmacytic Infiltrate

description: A morphologic finding indicating the presence of a lymphoplasmacytic infiltrate in a bone marrow specimen.


name: PD-L1 Expression Positive in Tumor Infiltrating Lymphocytes

description: An immunohistochemical test result indicating that expression of PD-L1 by tumor infiltrating lymphocytes was detected in in a sample.


name: Estrogen Receptor Positive by Immunohistochemistry 41-50 Percent

description: An immunohistochemical staining finding indicating that 41-50 percent of the cells in a tissue sample are expressing estrogen receptor.


Mature Neutrophils Present

description: An indication that mature neutrophils were detected in a sample.


name: Intersecting Sharply Marginated Clusters of Spindle Cells Present


Margin Involved by Invasive Carcinoma

description: A result that the margin is involved by invasive carcinoma.


Scattered Microscopic Foci

description: A microscopic finding indicating the presence of scattered islands of pathologic processes in a tissue sample.  The pathologic processes may refer to various abnormalities, including the presence of islands of malignant cells, presence of necrotic foci, and presence of islands of connective tissue that lack fibers.


Focal Podocyte Injury

description: A morphologic finding indicating focal damage or loss of the podocytes in the renal tissue.


PD-L1 Expression 1-49 Percent

description: An immunohistochemical finding indicating that at least 1 percent and at most 49 percent of the cells in a sample are expressing PD-L1.


Low Grade Dysplasia

description: A subjective characterization of the phenomenon of dysplasia, based on microscopic examination of the architectural and/or cytological changes in a tissue sample, that is determined to be low.


Adipocyte Accumulation

description: An increase of adipocytes in the extracellular space.


Breast Microcalcification

description: Tiny deposits of calcium in tissue.  In the breast they can be seen using mammography, and if found in clusters may be indicative of breast cancer.


name: Well Differentiated Neuroendocrine Lesion

description: A neoplastic lesion with neuroendocrine differentiation and well differentiated histological features.


name: Ki-67 Positive Cells Less than or Equal to 30 Percent

description: A semi-quantitative microscopic finding indicating that at most 30 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Koilocytotic atypia

description: An abnormality often noted in pap smears.  Koilocytotic atypia affects the squamous epithelium of the transformation zone. The cells involved show cytoplasmic vacuolization that might be related to their ability to store glycogen. The most characteristic feature of this condition is the peripheral cytoplasmic condensation associated with an increase of tonofilaments. (from Acta Cytol 1981;25:377-82)


Surgical Margins Status

description: The determination of the presence of actual or potential neoplastic tissue which has been left outside the boundary of a resected specimen within the patient.


name: Dilated Terminal Duct Lobular Units with Acini Lined by One or Two Layers of Columnar Epithelial Cells Present


CD2-Positive Neoplastic Cells Present

description: An indication that expression of CD2 has been detected in a sample of neoplastic cells.


Regional Metastasis Present

description: An indication that cancer cells have migrated from the primary tumor site and have been detected in adjacent tissues and/or regional lymph nodes.


Necrotic Lesion

description: A lesion characterized by irreversible damage leading to cellular death.


Macroscopic Satellite Nodule is Present

description: Satellite nodule in melanoma observed macroscopically.


Neurofibroma Architecture

description: The characteristic shape or pattern of neoplastic cells seen in a neurofibroma.


name: Microscopically Positive Parametrial Margin

description: The presence of microscopically visible residual tumor in surgical margins in the parametrial region.


name: High Phospho-AKT Immunohistochemical Expression


Eosinophilic Globules

description: A cellular droplet comprising fibrin degradation products or intracytoplasmic proteinaceous accumulations that can be stained by eosin.


name: No Evidence of Tumor Cell Necrosis Present

description: A morphologic finding indicating the absence of focal or diffuse tumor cell necrosis in a tissue sample.


name: Malignant Epithelial Cells with Cytoplasmic Vacuoles or Flocculent Cytoplasmic Inclusions Containing Wispy Eosinophilic Material Present

description: A morphologic finding indicating the presence of malignant epithelial cells with cytoplasmic vacuoles or flocculent cytoplasmic inclusions containing wispy eosinophilic material giving a bubbly appearance.


Colloid Alteration

description: Stippled, granular or clumped colloid, and/or variable staining characteristics, and often contains mineralized material and desquamated follicular cells. (INHAND)


Discordant Bone Marrow Histology

description: A finding, usually associated with lymphoma with bone marrow involvement, where the morphology observed in the bone marrow is different from that found in the primary nodal site.


Satellite Lesion

description: Nodules of melanoma located more than 0.05 mm from the primary lesion.


Focal Cortical Dysplasia Type 1

description: Focal cortical dysplasia characterized by abnormal cortical layering. It is associated with mild symptoms, late onset, and changes present in the temporal lobe. It includes the following: type Ia with abnormal radial migration and maturation of neurons; type Ib with disruption of the six-layered tangential composition of the cortex with immature neurons; and type Ic comprising both architectural abnormalities.


Squamous metaplasia of cervix

description: The process in which the cervical glandular epithelium is replaced with squamous epithelium.


Tubular Structures Present

description: A morphologic finding indicating the presence of an architectural pattern of tubular formations in a tissue sample.


Decidual endometritis

description: Acute inflammation characterized by neutrophilic infiltration of the decidua.


name: Neoplastic Small Cleaved Follicle Center Cells not Present


name: Minimal Reticulin Fibrosis of the Bone Marrow


Margin Involved by Invasive Melanoma

description: A result that the margin is involved by invasive melanoma.


ASPH-Positive Neoplastic Cells Present

description: An immunophenotypic finding indicating the expression of ASPH gene in the neoplastic cells of a tumor sample.


name: Immunoglobulin M-Positive Neoplastic Cells Present

description: A finding indicating the presence of immunoglobulin M-positive neoplastic cells in a tumor sample.


Loss of Corticomedullary Distinction

description: Decrease in corticomedullary distinction due to changes in lymphocyte cellularity.


name: Sarcomatous or Carcinomatous Component Present


Degeneration and Regeneration

description: A finding that generally has features of degeneration and regeneration.


Superficial Soft Tissue Fibrosis

description: Fibrotic degeneration of the superficial soft tissues.


Myxoid Changes Present

description: A morphologic finding indicating the presence of myxoid changes in a tissue sample.


name: PD-L1 Expression Positive in Tumor Cells

description: An immunohistochemical test result indicating that expression of PD-L1 was detected in a sample of tumor cells.


name: Progesterone Receptor Positive by Immunohistochemistry

description: An immunohistochemical staining finding indicating that cells in a tissue sample are expressing progesterone receptor.


Staining Intensity 3+

description: A measurement of the amount or proportion of tissue or cells that have a staining intensity of 3+.


Focal cytologic atypia

description: A morphologic finding indicating the presence of localized cytologic atypia in a tissue sample.


name: Progesterone Receptor Positive by Immunohistochemistry 81-90 Percent

description: An immunohistochemical staining finding indicating that 81-90 percent of the cells in a tissue sample are expressing progesterone receptor.


Prominent Intraductal Component Present

description: A morphologic finding that indicates the presence of a substantial neoplastic cellular proliferation within a ductal structure.


Metaplasia of Malignant Cells Present

description: Transformation of malignant cells with a specific differentiation to different morphologic types.


name: Barrett Esophagus With Metaplastic Goblet Cell Columnar Epithelium

description: A finding in an esophageal biopsy specimen indicating the diagnosis of Barrett esophagus associated with the presence of metaplastic columnar epithelium containing goblet cells.


name: Stromal Proliferation of Nevus Cells Present

description: A morphologic finding indicating the proliferation of nevus cells within the stroma of a tissue sample.


name: Parakeratinized Stratified Squamous Epithelium Present


Submucosal Lesion

description: A pathologic process that affects the loose connective tissue beneath the mucosa.


name: Dilated Terminal Duct Lobular Units with Acini Lined by More than Two Layers of Columnar Epithelial Cells Present


Esophageal Necrotic Lesion

description: A necrotic process involving the esophageal wall.


name: Increased Number of Hypersegmented Neutrophils Present

description: A morphologic finding indicating the presence of a high number of hypersegmented neutrophils in a peripheral blood smear.


name: Concentric Aggregates of Intermediate Filaments Present


name: Good Tissue Fixation with Definable Cellular Details


Dysplasia Negative

description: An indication that signs of dysplasia were not found in a sample.


Extracellular Vacuolation

description: A morphologic finding indicating the presence of extracellular clear spaces in a tissue sample.


Perineural Invasion Absent

description: An indication that perineural invasion is absent.


Ki-67 Positive Cells 3-55 Percent

description: A semi-quantitative microscopic finding indicating that between 3 and 55 percent of the cells in a sample are detected following staining using an anti-Ki-67 antibody.


Staining Intensity

description: The degree or magnitude of staining by a dye or reagent within a microscopic specimen.


Indefinite Dysplasia

description: An indication that there is an ambiguous morphological pattern in a tissue sample such that the presence or absence of dysplasia cannot be determined.


name: Carcinoma Exhibiting Undifferentiated or Dedifferentiated Features

description: A microscopic finding that refers to a carcinoma which is composed either exclusively of an undifferentiated cellular infiltrate, or a mixture of well differentiated and undifferentiated cellular infiltrates.


Tumor Cell Necrosis

description: A morphologic finding that indicates the presence of cells undergoing necrosis within a tumor.


name: Schwannian Stroma More than 50 Percent of the Tumor Volume


name: Histological Subtype Different, Pathology Review for this Project

description: The pathologic prescreen review for this project determined that the histologic subtype is different from the pathology report.


Renaut Body

description: Cylindrical, hyaline-appearing, loosely-textured, whorled, cell-sparse structures found in the subperincurial space in peripheral nerves. (Arthur K. Asbury, M.D. Renaut Bodies: A Forgotten Endoneurial Structure. Journal of Neuropathology & Experimental Neurology, Volume 32, Issue 2, April 1973, Pages 334-343)


Parasite Present

description: Confirmatory presence of parasitic microorganisms.


Well-Defined Tumor Margin

description: Sharp tumor/normal parenchymal boundaries on all margins.


Heterologous Elements Present

description: A morphologic finding indicating the presence of tissues that do not normally occur in the specific anatomic site or are found admixed with a neoplastic cellular infiltrate of a different cellular origin.


Cyst Formation

description: A morphologic finding indicating the presence of cystic structures in a tissue sample.


name: Multifocal Epithelial Proliferations Less than 1mm in Diameter Present


Papillary Projections Present

description: A morphologic finding indicating the presence of papillary projections lined by epithelial cells in a tumor sample.


Malignant Germinomatous Cells Present

description: A morphologic finding indicating the presence of germinoma, dysgerminoma, or seminoma germ cells.


name: Progesterone Receptor Positive by Immunohistochemistry Less than 1 Percent

description: An immunohistochemical staining finding indicating that less than 1 percent of the cells in a tissue sample are expressing progesterone receptor.


Moderate Immune Presence

description: Greater than 20-50 percent of the tissue surface area is occupied by immune cell infiltration.


name: NECTIN4 Expression by Immunohistochemistry 3+

description: An indication that the immunohistochemical staining intensity detected in a sample for NECTIN4 was 3+.


Lower Limb Soft Tissue Necrotic Lesion

description: A necrotic process affecting the soft tissues of the lower extremity.


Reticular Growth Pattern

description: A morphologic finding where the cells proliferate and give a net-like appearance to the lesion showing multiple spaces of varying sizes in between the cells.


MLH1 Nuclear Expression Intact

description: An indication that expression of MLH1 was detected in the nuclei of cells in a sample.


name: Melanin-Pigmented Dendritic Cells Present

description: A morphologic finding indicating the presence of melanin-pigmented dendritic cells in a tumor sample.


name: Osseous Metaplasia of Malignant Cells Present


H Score Staining Intensity 3+

description: A measurement of the amount or proportion of cells that have a staining intensity of 3+, based on the H Score scoring system, in a biological specimen. (McCarty KS Jr, Miller LS, Cox EB, et al. Estrogen receptor analyses: correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med. 1985;109(8):716-721).


MSH3 Loss of Nuclear Expression

description: An indication that expression of MSH3 was not detected in the nuclei of cells in a sample.


Clark Level II

description: A morphologic finding indicating that the cutaneous melanoma has invaded part of the papillary dermis but the malignant cellular infiltrate has not reached the papillary-reticular dermis interface.


Stromal Invasion

description: A term referring to the presence of tumor emboli or tumor masses within the stroma of an organ.


Fatty degeneration

description: Acumulation of adipose tissue in intracytoplasmic or extracellular spaces.


Margin Uninvolved by Sarcoma

description: The margin of the sample has no sarcoma.


Heterogeneous Breast Morphology

description: A finding indicating the presence of two or more distinct neoplastic cellular components in breast tissue.


H Score Staining Intensity 2+

description: A measurement of the amount or proportion of cells that have a staining intensity of 2+, based on the H Score scoring system, in a biological specimen. (McCarty KS Jr, Miller LS, Cox EB, et al. Estrogen receptor analyses: correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med. 1985;109(8):716-721).


name: proteinase-activated receptor 1 deaminated 1 (human)

description: A proteinase-activated receptor 1 (human) that has been deaminated on the residue at the position equivalent to Asn-75 of the amino acid sequence represented by UniProtKB:P25116. UniProtKB:P25116, Asn-75, MOD:00684.


name: PAR1_HUMAN Proteinase-activated receptor 1 (sprot)

description: A proteinase-activated receptor 1 that is encoded in the genome of human.