Myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia

Myelodysplastic syndrome characterized by mutation of SF3B1 gene. There is bone marrow dysplasia typically in one or more hematopoietic cell lineages. There are less than 5% blasts in bone marrow and less than 2% blasts in peripheral blood.


Stage IIB Cutaneous Melanoma AJCC v6 and v7

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Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0).  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Alkylating Agent-Related Acute Myeloid Leukemia

Acute myeloid leukemia occurring as late complication of prior therapy with alkylating agents.


Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified

A myelodysplastic/myeloproliferative neoplasm that does not meet the criteria of other myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes, and myeloproliferative neoplasms. It is associated with cytopenia, blasts less than 20% in bone marrow and peripheral blood, thrombocytosis, and absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.


Upper Extremity Fracture

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A traumatic break in one or more of the bones in the arm,  forearm, or hand.


Metastatic Penile Cancer

Carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Endometrioid intraepithelial neoplasia

A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations.


Metastatic Kidney Carcinoma

A carcinoma that arises from the kidney and has metastasized to another anatomic site.


Metastatic Ureter Carcinoma

Ureter carcinoma that has spread to another anatomical site.


Metastatic Urethral Carcinoma

A urethral carcinoma that has spread to another anatomical site.


Stage IIIC Breast Cancer AJCC v6

Stage IIIC Breast Cancer was added in the 6th Edition AJCC Staging Manual, on the basis of metastasis to the infraclavicular lymph nodes (N3) plus any T, M0.


AIDS-Related Plasmablastic Lymphoma

A plasmablastic lymphoma in a patient with acquired immunodeficiency syndrome.


Recurrent tumors of the Ewing's family

The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission.


Recurrent Peripheral Primitive Neuroectodermal Tumor

The reemergence of a small round cell tumor with neural differentiation after a period of remission.


Solar Radiation-Related Cutaneous Melanoma

Cutaneous melanoma that arises following exposure to solar radiation.


Alcohol-Related Carcinoma

A carcinoma that is caused by alcohol abuse.


Drug toxicity

An adverse effect of a drug used therapeutically or diagnostically.


Cardiotoxicity

Toxicity that impairs or damages the heart. This condition is often caused by the administration of a pharmaceutical agent that initiates a poisonous or toxic response in cardiac tissue.


Fracture of foot

A traumatic break in one or more of the bones in the foot.


Advanced Adult Hepatocellular Carcinoma

A hepatocellular carcinoma that occurs during adulthood and has spread extensively to other anatomic sites or is no longer responding to treatment.


Tropical Disease

Infectious and parasitic diseases endemic in tropical and subtropical zones, including Chagas' disease, leishmaniasis, leprosy, malaria, onchocerciasis, schistosomiasis, sleeping sickness, yellow fever, and others; often water- or insect-borne.


Fetal anomaly

Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate.


Adverse effects

The term was used in various ways in the past, to describe unintended effects of medical intervention, usually negative (unfavourable), but also positive (favourable) ones. It is recommended that this term no longer be used and particularly should not be regarded as synonymous with adverse event or adverse reaction.


Anoxia

Absence or reduction of oxygen in body tissue.


Complication

Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.


Cyst

A sac-like closed membranous structure that may be empty or contain fluid or amorphous material.


Cytopenia

A laboratory test result indicating an abnormally low quantity of circulating blood cells.


disease

A disease is a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism.


Fibrosis

The formation of fibrous tissue.


Hypertrophy

Abnormal enlargement of a body part or organ.


Inflammation

A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.


Leukemia, Myeloid, Chronic-Phase

A phase of chronic myeloid leukemia, BCR-ABL1 positive in which the peripheral blood smear shows leukocytosis with neutrophils in different stages of maturation, less than 2% blasts, and normal or increased platelet count. Most patients have mild anemia. The bone marrow is hypercellular due to increased numbers of neutrophils and their precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by granulocytes.


Lymphoma, Mixed-Cell

An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes.


Menopause

The permanent cessation of menses, usually defined by 6 to 12 months of amenorrhea in a woman over 45 years of age.


Menstruation

The normal physiologic discharge through the vagina of blood and mucosal tissues from the nonpregnant uterus.


Metaplasia

Transformation of a mature, normal cell or groups of mature cells to other forms of mature cells.  The capacity for malignant transformation of metaplastic cells is a subject of controversy.


Obstruction

Blockage of the normal flow of the contents of an anatomical passageway.


paragangliomas 1

Any paraganglioma in which the cause of the disease is a mutation in the SDHD gene.


Skin Discoloration

Abnormal skin coloration.


Digestive System Signs and Symptoms

Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion.


Swelling

Enlargement; expansion in size; sign of inflammation


Incontinence

Involuntary passage of stool or urine from the body.


trauma to the abdomen

Trauma to the abdomen.


Spontaneous abortion

Fetal loss at less than 20 weeks of gestation.


Alcoholic Intoxication

Disturbances in psychophysiological functions and responses as a result of  consumption of a beverage containing ethanol.


Athletic Injuries

An injury sustained while practicing or competing in a sport.


Chronic iridocyclitis

Uveitis that is usually insidious in onset, bilateral, and can be asymptomatic, most often affecting the anterior uveal tract, including the iris and ciliary body, and can result in long-term complications. It is most commonly associated with certain forms of juvenile idiopathic arthritis, but may occur independent of arthritis.


Corn of toe

A thickening of the skin due to friction or pressure which results in the formation of a small, painful, raised bump associated with a conical mass pointing down into the dermis.


Lymphoma, Intermediate-Grade

An antiquated term that refers to a non-Hodgkin lymphoma with intermediate grade histologic features.


Lymphoma, Large-Cell, Follicular

A follicular lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


Bronchospasm, Exercise-Induced

Sudden contraction of the smooth muscles of the bronchial wall that occurs during or following exercise.


Facial Injuries

Trauma to the face.


Lymphoma, Low-Grade

An antiquated term that refers to a non-Hodgkin lymphoma with low grade histologic features.


Fractures, Closed

A traumatic break to the bone in which the continuity of the bone has not broken through the skin.


Fractures, Open

A traumatic break to the bone in which the continuity of the bone has broken through the skin.


Adult Diffuse Small Cleaved Cell Lymphoma

An antiquated term for a diffuse B-or T-cell lymphoma composed of small cleaved lymphocytes, occurring in adults.


Globus Hystericus

Persistent or intermittent non-painful sensation of a lump or foreign body in the throat occurring between meals in the absence of dysphagia, odynophagia, evidence of gastroesophageal acid reflux, or histopathogically based esophageal motility disorders.


Lymphoma, Small Cleaved-Cell, Follicular

A follicular lymphoma which contains up to 5 centroblasts per 40X high-power microscopic field.


Intraoperative Complication

A disease or disorder that occurs during the course of a surgical procedure.


Leg Injuries

Trauma to the lower extremity, which is confined to the area between the hip and ankle joints.


Loneliness

Sadness resulting from being isolated or alone.


Menopausal syndrome

A grouping of variable physical, vasomotor and psychological symptoms in climacteric females. Physical symptoms include: cessation of menses, headaches, fatigue, weight gain and vaginal dryness. Vasomotor symptoms typically include: palpitations, hot flashes and night sweats. Psychological symptoms may include: decrease in libido, emotional lability, difficulty concentrating and insomnia.


Postoperative Hemorrhage

Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related.


Primary Insomnia

A sleep disorder characterized by difficulty initiating or maintaining sleep; this difficulty does not occur in the context of another sleep disorder and is not etiologically linked to a mental disorder, substance use, or a general medical condition.


Fractured rib

A partial or complete breakage of the rib.


schizophrenia 10

A schizophrenia that has material basis in an autosomal dominant mutation of SCZD10 on chromosome 15q15.


Schizophrenia, Childhood

Schizophrenia occurring in childhood.


Schizophrenia, Disorganized

A subtype of schizophrenia characterized by disorganized speech, disorganized behavior, and a flat or inappropriate affect; associated features include grimacing, mannerisms, and other oddities of behavior. Criteria for the catatonic type of schizophrenia are not met.


Hemorrhagic Shock

Hypoperfusion of body tissues due to acute blood loss, resulting in cellular injury and vital organ dysfunction.


Surgical Shock

Hypoperfusion of body tissues occurring during or after a surgical procedure, and resulting in cellular injury and vital organ dysfunction.


Fractured shoulder

A fracture or multiple fractures of the humerus (ball) or the glenoid (socket) of the shoulder joint.


Sprain

A stretching or tearing of a ligament.


Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities.


Sunstroke

A reaction to prolonged exposure to high temperatures that can result in a failure of the body's temperature control system. It is often characterized by body temperature over 105 degrees, dehydration, headache, dizziness, nausea, vomiting, and muscle weakness.


Tooth Abrasion

Wearing away of tooth enamel by an outside mechanical force.


Vascular Headaches

Headache caused by abnormal functioning of the vascular system.


Adnexal mass

An abnormal growth in the ovary, fallopian tube, or surrounding connective tissue.


Elbow Injuries

Trauma to the elbow joint.


Foot Injuries

Trauma to the foot.


Chronic glomerulonephritis

A chronic, persistent inflammation of the glomeruli, which is slowly progressive, leading to impaired kidney function.


Crohn's disease of small intestine

Crohn's disease affecting the small intestine.


Injury of gastrointestinal tract

Trauma to the gastrointestinal tract or accessory organs of digestions.


Perceptual disturbance

A misperception of sensory stimuli.


Hepatic Mass

A space-occupying pathologic process that affects the liver parenchyma.


Renal Mass

An abnormal growth in the kidney.


Crushing injury

Traumatic compression of the body or a part of the body.


Inferior Myocardial Infarction by ECG Finding

An electrocardiographic finding of pathologic Q waves in leads III, aVF and often II, which is suggestive of myocardial infarction of the inferior wall of the left ventricle. (CDISC)


Cardiovascular injury

Trauma to the heart and/or blood vessels.


Bone injury

Trauma to bone.


Throat cancer

Carcinoma, predominantly squamous cell, arising from epithelial cells of the larynx or pharynx.


Limb injury

Trauma to an arm or leg.


Lymph Node Mass

A benign or malignant solid pathologic process involving a lymph node.


Chronic Insomnia

Insomnia that has persisted at least one month.


Pulmonary vascular disorder

A category of non-neoplastic disorders that affect the blood vessels in the lungs.  Representative examples include pulmonary embolism, pulmonary hypertension, and arteriovenous malformations.


Cardiovascular System Finding

Symptoms, physical examination results, and/or laboratory test results related to the cardiovascular system.


Complex Endometrial Hyperplasia with Atypia

A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures.  It is associated with cytologic atypia and an increased risk of endometrial adenocarcinoma.


Rare Neoplastic Syndrome

A broad classification for uncommon disorders in which the development of neoplasms occur in association with a characteristic set of signs or symptoms. These disorders commonly have a genetic basis. The types of neoplasms themselves are not necessarily uncommon.


Traumatic hemorrhage

Vascular rupture, and the resulting loss of blood, due to physical injury.


Glomerular vascular disorder

A disorder that is caused by pathologic changes in the glomerular vasculature.


Cartilage injury

Trauma to cartilage.


Upper Respiratory Infections

An infectious process affecting the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea). Symptoms include congestion, sneezing, coughing, fever, and sore throat.


Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the ocular adnexa. It is the most common type of primary ocular adnexal lymphoma.


Stage IVA Major Salivary Gland Cancer AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Moderately advanced disease.  Tumor invades skin, mandible, ear canal, and/or facial nerve. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension.  Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension.  T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVB Major Salivary Gland Cancer AJCC v7

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced disease.  Tumor invades skull base and/or pterygoid plates and/or encases carotid artery. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVC Major Salivary Gland Cancer AJCC v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


brainstem cancer

A primary or metastatic malignant neoplasm that affects the brain stem.


Chest Wall Disorder

A non-neoplastic or neoplastic disorder that affects the structures of the chest wall.  Representative examples include infection, chest wall lipoma, and chest wall lymphoma.


Secondary malignant neoplasm of lung

The spread of a malignant neoplasm to the lung. This may be from a primary lung malignant neoplasm, or from a malignant neoplasm at a distant site.


Metastatic malignant neoplasm to pleura

The spread of a malignant neoplasm to the pleura from an adjacent or distant anatomic site.


Metastatic malignant neoplasm to bone

Evidence of secondary malignant neoplasm of bone and bone marrow.


Hodgkin's disease, nodular sclerosis of lymph nodes of multiple sites

Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Hodgkin's disease mixed cellularity stage III


Hodgkin's disease, lymphocytic depletion of lymph nodes of multiple sites


Plasma cell leukemia in remission

A finding of plasma cell leukemia that is not growing and responds to treatment.


Acute lymphoid leukemia in remission

A finding of acute lymphoblastic leukemia that is not growing and responds to treatment.


Chronic lymphoid leukemia in remission

A finding of chronic lymphocytic leukemia that is not growing and responds to treatment.


Acute myeloid leukemia in remission

A finding of acute myeloid leukemia that is not growing and responds to treatment.


Chronic myeloid leukemia in remission

A finding of chronic myelogenous leukemia, BCR-ABL1 positive that is not growing and responds to treatment.


Distantly Metastatic Malignant Neoplasm

A malignant tumor that has spread from its original (primary) site of growth to another site distant from the primary site.


Localized Neoplasm

A neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Poorly Differentiated Malignant Neoplasm

A neoplasm whose histologic characteristics have regressed and are more similar to stem cells.


Chronic Myelomonocytic Leukemia-1

A chronic myelomonocytic leukemia characterized by the presence of less than 10 percent blasts in the bone marrow and less than 5 percent blasts in the peripheral blood.


Chronic Myelomonocytic Leukemia-2

A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count.


Peripheral neuroepithelioma of bone metastatic

A small round cell tumor of the bone with neural differentiation that has spread from its original site of growth to another anatomic site.


Anaplasia

A morphologic finding indicating the presence of a malignant cellular infiltrate characterized by the presence of large pleomorphic cells, necrosis, and high mitotic activity in a tissue sample.


Accelerated Phase of Disease

The phase of a disease characterized by laboratory and clinical findings that indicate rapid progression.


Blasts 20 Percent or More of Bone Marrow Nucleated Cells

A semi-quantitative microscopic finding indicating that 20 percent or more of the nucleated cells in a bone marrow sample are immature mononuclear cells.


Blasts Under 20 Percent of Peripheral Blood White Cells

A semi-quantitative microscopic finding indicating that less than 20 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


Lymphomatous Adult T-Cell Leukemia/Lymphoma

An adult T-cell leukemia/lymphoma characterized by generalized lymphadenopathy without peripheral blood involvement.  Most patients have advanced disease, however hypercalcemia is not frequently present.


Deformity

An anatomic abnormality that is either present at birth or appears later in life.


Breast Carcinoma Metastatic in the Brain

A carcinoma that has spread to the brain from its original site in the breast, through the hematogenous route.


Breast Carcinoma Metastatic in the Liver

A carcinoma that originates from the breast and has spread to the liver.


Breast Carcinoma Metastatic in the Bone

A carcinoma that arises from the breast and has metastasized to the bone.


Lung Carcinoma Metastatic in the Brain

A carcinoma that has spread to the brain from its original site in the lung, through the hematogenous route.


Prostate Carcinoma Metastatic in the Bone

A carcinoma that arises from the prostate gland and has spread to the bone.


Colon Carcinoma Metastatic in the Liver

A carcinoma that originates from the colonic wall and has spread to the liver.


Neoplasm of uncertain behavior

A neoplasm displaying morphologic, phenotypic, or genotypic characteristics that are clearly not benign but do not permit the establishment of a definitive diagnosis of malignancy.  Such neoplasms may or may not eventually have a more aggressive clinical course.  Representative examples include lymphoproliferations of uncertain malignant potential (e.g., lymphomatoid granulomatosis and lymphomatoid papulosis), borderline ovarian epithelial neoplasms (e.g., borderline ovarian endometrioid tumor and borderline ovarian mucinous tumor), borderline exocrine pancreatic neoplasm (e.g., pancreatic borderline intraductal papillary-mucinous neoplasm), and primary borderline peritoneal epithelial neoplasm.


Cyst of thyroid

Abnormal fluid filled sac within the thyroid gland.


Traumatic injury

Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.


Carcinomatosis

Carcinoma that has spread diffusely to an anatomic site or throughout the body.


Systemic Anaplastic Large Cell Lymphoma, ALK-Negative

Anaplastic large cell lymphoma, ALK-negative affecting multiple anatomic sites.


Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

Small lymphocytic lymphoma characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


bladder flat intraepithelial lesion

A non-papillary neoplasm of the urinary bladder, whose classification categories include low-grade intraurothelial neoplasia and urothelial carcinoma in situ.


Head and Neck Basaloid Carcinoma

A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region.  The most common sites of origin are pyriform sinus, epiglottis, and base of tongue.  It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.  Comedonecrosis may be present.


Adenomatous Polyps

A polypoid neoplasm arising from the glandular epithelium of the gastrointestinal tract. There is proliferation of glandular cells which may display dysplastic cytologic features. Representative examples include the adenomatous polyps of the colon and rectum..


Distress

A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures.


Hypercholesterolemia

A laboratory test result indicating an increased amount of cholesterol in the blood.


Carcinoma of unknown primary

A carcinoma which has metastasized from an unknown primary anatomic site.


Metastatic malignant neoplasm to brain

A malignant neoplasm that has spread to the brain from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


Malignant ascites

Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic malignant neoplasms in the peritoneum.


Recurrent disease

The return of a disease after a period of remission.


Systolic Hypertension

Abnormally high systolic blood pressure.


Traditional Serrated Adenoma

An adenoma that arises from the large intestine and the appendix.  It is characterized by prominent serration of the glands.


Menopausal Symptom

Any of the mental or physical manifestations that accompany perimenopause and menopause.


Bulky Disease

Bulk at a site (other than the mediastinum) where any mass measures 10 cm or more by an imaging study.


Generalised illness

A pathologic process that has spread from its original site of growth to multiple distant anatomic sites.


Grade I Meningioma

A benign meningioma which may recur in approximately 7-20% of the cases.  This category includes the angiomatous meningioma, fibrous meningioma, lymphoplasmacyte-rich meningioma, meningothelial meningioma, metaplastic meningioma, microcystic meningioma, psammomatous meningioma, secretory meningioma, and transitional meningioma.


Neoplasm, Residual

Evidence for remaining tumor following primary treatment that is only apparent using highly sensitive techniques.


Radiation enteritis of intestine

Inflammation of the small intestine caused by radiation exposure.


Borderline hypertension

Blood pressure in the zone between the highest normal level and the level that is considered hypertensive.


Hypertension Secondary To Endocrine Disorders

Evidence of hypertension secondary to endocrine disorders.


Hepatic cysts

A cystic lesion located in the liver.


CD30-Positive Neoplastic Cells Present

A finding that a sample of neoplastic cells has detectable immunoreactivity for CD30 (TNFRSF8).


Immune System Finding

Symptoms, physical examination results, and/or laboratory test results related to the immune system.


Pleomorphic Variant Mantle Cell Lymphoma

An aggressive mantle cell lymphoma characterized by the presence of pleomorphic neoplastic B-lymphocytes.


IDH-wildtype glioblastoma

A glioblastoma that is characterized by high cellularity, high mitotic activity, necrosis or microvascular proliferation and that lacks mutations in IDH genes.


Secondary Glioblastoma

A glioblastoma arising from a lower grade astrocytoma.


Invasive Bladder Urothelial Carcinoma with Squamous Differentiation

An invasive urothelial carcinoma of the bladder that exhibits squamous differentiation.


Invasive Bladder Urothelial Carcinoma with Glandular Differentiation

An invasive urothelial carcinoma of the bladder that exhibits glandular differentiation.


Invasive Bladder Urothelial Carcinoma with Trophoblastic Differentiation

An invasive bladder urothelial carcinoma characterized by the presence of trophoblastic differentiation.


infiltrating bladder lymphoepithelioma-like carcinoma

Invasive bladder urothelial carcinoma with lymphoepithelioma-like features.


Invasive Bladder Giant Cell Urothelial Carcinoma

An invasive urothelial carcinoma of the bladder with giant cells.


hyper-IgM syndrome

A primary immune deficiency disorder characterized by defective CD40 signaling; via B cells affecting class switch recombination (CSR) and somatic hypermutation.


Prostate Adenocarcinoma with Neuroendocrine Differentiation

An invasive prostate adenocarcinoma characterized by the presence of malignant cells that exhibit neuroendocrine differentiation.


testicular sex cord-stromal neoplasm

A benign or malignant tumor that arises from the testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the tumor or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, ten percent of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group.


Stage IV Breast Cancer AJCC v6 and v7

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


Ovarian Sex Cord-Stromal Tumor, Not Otherwise Specified

A sex cord-stromal tumor that arises from the ovary and lacks the morphologic features that belong to the categories of granulosa-stromal tumors, Sertoli-stromal tumors, or steroid cell tumors.


Colon cancer recurrent

The reemergence of colon carcinoma after a period of remission.


Malignant Ovarian Steroid Cell Tumor

A steroid tumor of the ovary which has an aggressive clinical course and metastasizes to other anatomic sites. It is usually of large size and is characterized by nuclear atypia, increased mitotic activity, hemorrhage, and necrosis. Sometimes, patients have abdominal metastases at presentation.


Esophageal carcinoma recurrent

An esophageal carcinoma which has reappeared after a period of remission or after presumed treatment.


Stage IV Renal Cell Cancer

Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades beyond Gerota's fascia.  N0: No regional lymph node metastases.  N1: Metastasis in a single regional lymph node.  N2: Metastasis in more than one regional lymph node.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 6th ed.)


Borderline Ovarian Mucinous Tumor

A low grade mucinous epithelial neoplasm arising from the ovary.  It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion.  The mucinous epithelial cells may be of intestinal or endocervical type.


Recurrent Cancer of Gallbladder

The reemergence of gallbladder carcinoma after a period of remission.


Adult Craniopharyngioma

A craniopharyngioma that occurs during adulthood.  It can be either adamantinomatous or papillary.  The papillary histologic variant occurs virtually exclusively in adults.  Clinical signs and symptoms include visual disturbances and endocrine deficiencies.


Fallopian Tube Serous Neoplasm

A benign, borderline, or malignant epithelial tumor of the fallopian tube characterized by the presence of neoplastic serous epithelial cells.


Metastatic non-small cell lung cancer

Stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b).  M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion.  M1b: Distant metastasis. (AJCC 7th ed.)


FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


High Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


CNS metastases

A malignant neoplasm that has spread to the central nervous system from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


Paget's disease and intraductal carcinoma of breast

Paget disease of the breast associated with the presence of a usually high grade ductal carcinoma in situ in the lactiferous glands.


Cervical intraepithelial neoplasia grade 2

Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper half of the squamous epithelium and conspicuous nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal two thirds of the epithelium.


Vaginal Adenosquamous Carcinoma

A carcinoma that arises from the vagina and is characterized by the presence of malignant glandular and malignant squamous epithelial components.


Carcinoma larynx recurrent

The reemergence of laryngeal carcinoma after a period of remission.


Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome.


Ductal Carcinoma In Situ with Microinvasion

Invasive breast carcinoma measuring 1 mm or less in size.


Adenocarcinoma of Unknown Primary

An adenocarcinoma which has metastasized from an unknown primary anatomic site.


No Evidence of Disease

Diagnostic tests fail to detect presence of disease.


AIDS-Related Malignant Neoplasm

Malignant neoplasms that develop in HIV infected patients.  The most common AIDS-related malignant neoplasms are Kaposi sarcoma, non-Hodgkin lymphoma, anal carcinoma, cervical carcinoma, and Hodgkin lymphoma.


Condyloma anal

A human papillomavirus-related neoplasm arising from the anus. Morphologically, it is characterized by an exophytic papillary proliferation of squamous cells and acanthosis.


Metastatic Lesion

A tumor arising at a location distant to the primary lesion.


Endometrioma

A cystic form of endometriosis affecting the ovary.  It may or may not be associated with endometriosis in other areas in the pelvis.


Dysplasia

A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer.


Vasoconstriction

Vasoconstriction involves narrowing of a blood vessel lumen due to smooth muscle contraction in the vessel wall and leads to decreased blood flow.


Solitary mass

A single isolated mass.


Post-polycythemia vera myelofibrosis

Progression of polycythemia vera characterized by decreased erythropoiesis and granulopoiesis, reticulin and collagen fibrosis of the bone marrow, leucoerythroblastic reaction in the peripheral blood, poikilocytosis, tear-drop shaped red blood cells, and splenomegaly.


Overt Primary Myelofibrosis

Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


Adenocarcinoma, metastatic

An adenocarcinoma that has spread from its original site of growth to another anatomic site.


Adverse event

Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s).


Adverse reactions

Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.


Withdrawal (dysfunction)

A social or emotional detachment, pathological retreat from objective reality, interpersonal contact and social involvement, as in some forms of schizophrenia, depression, or schizoid, avoidant, or schizotypal personality disorders.


Adenomatous colonic polyposis

Presence of multiple adenomatous polyps in the colon.


Craving

The desire to experience the effect(s) of a previously used psycho-active substance. It has to be noted that not all drug craving is based on withdrawal, since craving can often occur in the absence of withdrawal.


Blasts Under 20 Percent of Bone Marrow Nucleated Cells

A semi-quantitative microscopic finding indicating that less than 20 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells.


Blasts Under 10 Percent of Bone Marrow Nucleated Cells

A semi-quantitative microscopic finding indicating that less than 10 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells.


Cellular infiltrate

A morphological finding where an influx of cells is detected in locations or numbers that those cells are not normally found.


Lipid cell tumor of ovary

An ovarian tumor in which the vast majority of the cells (more than 90% of the tumor cells) resemble steroid hormone-secreting cells. It usually presents with androgenic manifestations. Approximately one-third of the cases follow a malignant clinical course.


Atypical fibroxanthoma of skin

An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, usually affecting the actinic-damaged skin of the elderly.  The tumor presents as a single cutaneous nodule which is often ulcerated.  Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. The vast majority of patients have an excellent prognosis following conservative therapy. Recurrences are infrequent, and metastasis is rare.


Therapy-Related Toxicity

The finding of bodily harm due to the poisonous effects associated with the action or administration of therapeutic agents.


Premalignant Lesion

A lesion characterized by the proliferation of atypical or dysplastic cells without evidence of stromal invasion.


Trichilemmal carcinoma

A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required.


Extraocular Cutaneous Sebaceous Carcinoma

A rare variant of sebaceous carcinoma that does not affect the ocular region.


Malignant cylindroma of skin

A carcinoma that arises in a cylindroma.


Squamoid eccrine ductal carcinoma

A variant of ductal eccrine carcinoma with squamoid metaplasia.


Hutchinson's Melanotic Freckle

An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, without infiltration of the papillary or reticular dermis. The melanocytic proliferation is associated with actinic damage and epidermal atrophy.  It usually occurs in the sun-exposed skin of elderly people.  It is a form of melanoma in situ.


cutaneous adenocystic carcinoma

A adenoid cystic carcinoma that involves the skin of body.


Diffuse large B-cell lymphoma, unclassifiable, NOS

A biologic subset of diffuse large B-cell lymphomas (DLBCL) that do not overexpress the genes whose overexpression characterizes the germinal center B-cell-like and activated B-cell-like DLBCL.  Morphologically, these lymphomas are either immunoblastic or centroblastic.  Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome, similar to those with an activated B-cell-like gene expression profile.


Respiratory System Finding

Symptoms, physical examination results, and/or laboratory test results related to the respiratory system.


Low Grade Dysplasia in Ulcerative Colitis

A morphologic finding indicating the presence of low grade colorectal epithelial dysplasia secondary to ulcerative colitis.


Mixed subtype adenocarcinoma of lung

The most frequently seen morphologic variant of lung adenocarcinoma characterized by a mixture of architectural patterns, including acinar, papillary, bronchioloalveolar, and solid pattern.


Lung Typical Carcinoid Tumor

A neuroendocrine tumor of the lung characterized by the absence of necrosis and the presence of less than 2 mitoses per 10 high power fields.


Malignant carcinoid tumor of lung

A neuroendocrine tumor of the lung showing focal necrotic changes or a number of mitotic figures between 2 and 10/10 high power fields.


Low Grade Lung Neuroendocrine Neoplasm

A low grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes typical carcinoid tumor.


Intermediate Grade Lung Neuroendocrine Neoplasm

An intermediate grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes atypical carcinoid tumor.


respiratory system cancer

A malignant neoplasm involving the respiratory system


Metastatic malignant neoplasm to bone marrow

The spread of a malignant neoplasm from its original site of growth to the bone marrow.


Metastatic malignant neoplasm to peritoneum

The spread of a malignant neoplasm to the peritoneum from another primary anatomic site.


Pancreatic Neuroendocrine Tumor G2

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the pancreas. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3-20%.


Unilateral Breast Carcinoma

Breast carcinoma of one breast, or one side of the breast.


Sporadic Thyroid Gland Medullary Carcinoma

A non-hereditary medullary carcinoma of the thyroid gland not associated with multiple endocrine neoplasia.  The majority of thyroid gland medullary carcinomas are sporadic.


multiple endocrine neoplasia type 2A

Multiple endocrine neoplasia caused by mutation of the RET gene. Patients develop medullary thyroid carcinomas, and may also develop pheochromocytomas and parathyroid gland hyperplasia.


Cervical intraepithelial neoplasia grade 1

Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Pleomorphic adenoma of parotid gland

A benign, slow-growing tumor that arises from the parotid gland.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin and women are more often affected than men.


Proliferative verrucous oral leukoplakia

Warty leukoplakia on the oral mucosa.  It is associated with a high risk for malignant transformation.


Metastatic malignant neoplasm to liver

A malignant neoplasm that has spread to the liver from another (primary) anatomic site. Representative examples include carcinomas, lymphomas, melanomas, or sarcomas.


Vulval intraepithelial neoplasia grade 2

An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by loss of maturation, nuclear hyperchromasia, high nuclear:cytoplasmic ratios, cytological and architectural atypia, and mitoses. Two morphological patterns have been described: basaloid (undifferentiated) and warty (condylomatous, bowenoid). It carries a significant but relatively low risk of progression to squamous cell carcinoma if untreated. (WHO 2020)


Recurrent tumor

The reemergence of a neoplasm after a period of remission.


Residual Tumor

Tumor cells that remain in the body following cancer treatment.


Malignant odontogenic tumor

A sarcoma that arises from tooth-forming tissues.


Recurrent Malignant Neoplasm

The reemergence of a malignant neoplasm after a period of remission.


Dysplasia of larynx

Mild, moderate, or severe dysplasia of the squamous epithelium of the laryngeal mucosa.


Invasive Cutaneous Melanoma

A melanoma of the skin that is not confined to the dermal-epidermal junction, and has infiltrated the dermis.


Mucosal lentiginous melanoma

An acral lentiginous melanoma affecting mucosal surfaces.


Rare Diseases

A non-neoplastic or neoplastic disorder that is uncommon.


Symptom

Subjective evidence of disease perceived by the patient.


Metastatic malignant neoplasm to vertebral column

The spread of a malignant neoplasm to the spine.  This may be from a primary spinal malignant neoplasm, or from a malignant neoplasm at a distant site.


Chronic acquired lymphedema

A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation.


HIV lipodystrophy

A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat.  It is associated with antiretroviral therapy.  Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs.


Chronic leukemia in remission

A finding of chronic leukemia that is not growing and responds to treatment.


Lymphoid leukemia in remission

A finding of lymphoid leukemia that is not growing and responds to treatment..


Low grade myofibroblastic sarcoma

A low-grade malignant neoplasm arising from the soft tissue and rarely bone. It is characterized by the presence of spindle-shaped myofibroblasts and collagenous stroma formation in a storiform growth pattern. Metastasis is very rare.


Myxoinflammatory fibroblastic sarcoma

A low grade, locally aggressive, fibroblastic neoplasm that occurs primarily in the distal extremities.  It is characterized by the presence of spindle-shaped fibroblasts, multivacuolated lipoblast-like cells, bizarre ganglion-like cells with inclusion-like nuclei, myxoid stroma formation, and a mixture of acute and chronic inflammatory cells.  Distant metastases are very rare.


Sclerosing Epithelioid Fibrosarcoma

A well-circumscribed malignant fibroblastic neoplasm that usually arises from the soft tissue. It is characterized by the presence of nests of malignant epithelioid fibroblasts and sclerotic collagen stroma formation.


Malignant fibrous histiocytoma metastatic

An undifferentiated pleomorphic sarcoma that has spread to other anatomic sites.


Soft Palate Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the soft palate.  It usually presents as an ulcerated or fungating mass.


Leptomeningeal Neoplasms

A malignant neoplasm that has spread from its original site to the two innermost layers of tissue that cover the brain and spinal cord.


Treatment related secondary malignancy

The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself.


Central Nervous System Vascular Malformations

A congenital abnormality of the arteries and veins that is located in the brain or spina cord, and which may increase the risk of bleeding, possibly resulting in impaired mental or physical function.


Carcinoma Unspecified Site

Carcinoma in which the site of involvement is not specified.


Oropharyngeal candidiasis

Infection of the oropharynx with, or disease caused by, Candida, especially C. albicans. This disease usually results from debilitation (as in immunosuppression and especially AIDS), physiologic change, prolonged administration of antibiotics, and iatrogenic and barrier breakage. SYN candidosis, moniliasis.


Nodal marginal zone B-cell lymphoma refractory

Nodal marginal zone B-cell lymphoma resistant to treatment.


Nodal marginal zone B-cell lymphoma recurrent

The reemergence of nodal marginal zone lymphoma after a period of remission.


Follicle center lymphoma, follicular grade I, II, III stage IV

Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Follicular lymphoma recurrent

The reemergence of follicular lymphoma after a period of remission.


Lung squamous cell carcinoma recurrent

The re-emergence of squamous cell lung carcinoma after a period of remission.


Pancreatic carcinoma non-resectable

Carcinoma of the pancreas that is not amenable to surgical removal.


Stage IV Esophageal Squamous Cell Carcinoma AJCC v7

Stage IV includes: Any T, Any N, M1, Any G, Tumor location: Any.  M1: Distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Stage III Esophageal Squamous Cell Carcinoma AJCC v7

Stage III includes: IIIA (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any); IIIB (T3, N2, M0, Any G, Tumor location: Any); IIIC (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Stage II Esophageal Squamous Cell Carcinoma AJCC v7

Stage II includes: IIA (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X); IIB (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Abnormal Mammogram

A radiologic finding indicating the presence of abnormalities in the breast parenchyma identified in a mammogram performed for screening or diagnostic purposes.  These abnormalities include calcifications, breast tissue distortion, presence of areas of density, and presence of benign or malignant tumors.


Premature skin wrinkling

The presence of an increased degree of wrinkling (irregular folds and indentations) of the skin as compared with age-related norms.


Contusions

Injury of the soft tissues or bone without breaking the skin that is characterized by blood leakage into the surrounding area.


Laceration

A cut or tear in any tissue.


Cognitive changes

Pertaining to or characterized by cognition. That operation of the mind which we become aware of objects of thought or perception; it includes all aspects of perceiving, thinking, or remembering.


Asphyxia

A state of general hypoxia and hypercapnea, resulting in acidosis, which affects all tissues in the body.


Blood Loss

Loss of blood from the circulation, either internally or externally.


Cancer Other

A finding indicating the presence of a malignancy that is not further specified or defined.


Claudication

Pain, cramping, and fatigue of the lower extremities upon ambulation due to ischemia.


Abortion complete

Expulsion of all the products of conception following spontaneous, medical or operative pregnancy termination.


Brain Concussion

A violent jar or shock, or the condition which results from such an injury.


Corneal burn

Chemical or radiant injury to the cornea.


Corneal decompensation

Endothelial decompensation that is manifested by opacity of the cornea. The condition often occurs as a nonspecific response to mechanical injury from incidental corneal contact by intraocular instruments during surgery; chemical injury from the improper use of intraocular drugs, drugs containing preservatives, or from residues from inadequate rinsing of detergents or other residues from surgical instruments. The most common causes of corneal endothelial decompensation in the adult population are cataract removal/IOL-related endothelial loss and Fuchs dystrophy. When severe, corneal endothelial decompensation requires corneal transplantation.


AIDS-Related Non-Hodgkin Lymphoma

A non-Hodgkin lymphoma that develops in a patient with AIDS.


Infiltrate of cornea

Discrete, small lesions present in the cornea as a result of corneal inflammation and, in some cases, after soft contact lens wear especially extended-wear lenses.


Discomfort

A feeling of mental or physical uneasiness, pain, or distress.


Electrolyte imbalance

Higher or lower than normal values for the serum electrolytes; usually affecting NA, K, CHL, CO2, glucose, bun.


Fetal Hypoxia

Hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration.


Hyperemia

The presence of an increased amount of blood in a part or organ; engorgement.


Epithelioid sarcoma recurrent

The reemergence of epithelioid sarcoma after a period of remission


Unspecified abortion incomplete

The uterus is not entirely emptied of products of conception following spontaneous, medical or operative pregnancy termination.


Induced Abortion Finding

Abortion brought on intentionally.


Cancer Fatigue

A debilitating tiredness or total lack of energy, often reported as the most common symptom in individuals with cancer.  Cancer fatigue can result from chemotherapy, radiation therapy, surgery, and other treatments; chemotherapy-induced anemia is a very frequent cause. -- 2004


Fetal Death

A fetus of at least 20 weeks gestation, or of a birth weight of at least 350 grams if the gestational age is unknown, that is born without signs of life at the time of delivery, and with an Apgar score of zero at both one and five minutes.


Irritation

A mild inflammatory tissue reaction; it can be caused by physical contact with an irritant or can be a local response to a systemic trigger.


Ligament injury

An injury to any of the fibrous bands of tissue that comprise an articulation (joint).


Missed abortion

Retention in uterus of an abortus.


Nerve injury

Injury to nervous tissue.


Postoperative shock

A state of shock following a surgical operation.


Prosthetic Valve Thrombosis

The formation of a blood clot that is attached to or near an artificial heart valve; this can cause dysfunction of the valve, and possibly lead to an embolic event should the thrombus become dislodged.


Regurgitation

Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent.


Skin Irritation

A mild inflammatory dermal tissue reaction; it can be caused by physical contact with an irritant or can be a local response to a systemic trigger.


Stenosis

Narrowing or stricture of a vessel, duct or canal.


Asymptomatic Infections

Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps.


Thermal burn

A burn injury caused by heat or fire.


Tooth Fractures

Broken tooth affecting any portion of tooth: root fracture, crown-root, broken tooth (crown fracture), chipped tooth. A crown fracture can involve the pulp. Tooth fracture sequelae range in severity from cosmetic defects to tooth death. Involvement of the pulp is a more important indicator of severity of tooth fracture than is the amount of the tooth affected.


Shock, Traumatic

Any shock produced by trauma.


Heart valve regurgitation

Dysfunction of one of the cardiac valves characterized by incomplete valve closure.


Optic Nerve Injuries

Injury to the optic nerve.


Extranodal marginal zone B-cell lymphoma (MALT type) stage II

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage II disease.


Extranodal marginal zone B-cell lymphoma (MALT type) stage III

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage III disease.


Drug Overdose

Exposure to, or intake of, an excessive amount of a substance.


Extranodal marginal zone B-cell lymphoma (MALT type) stage IV

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage IV disease.


Extranodal marginal zone B-cell lymphoma (MALT type) recurrent

The reemergence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue after a period of remission.


Extranodal marginal zone B-cell lymphoma (MALT type) refractory

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that is resistant to treatment.


Premature Obstetric Labor

Regular uterine activity with associated cervical change prior to 37 weeks gestation.


Splenic marginal zone lymphoma stage III


Splenic marginal zone lymphoma recurrent

The reemergence of splenic marginal zone lymphoma after a period of remission.


Splenic marginal zone lymphoma refractory

Splenic marginal zone lymphoma that is resistant to treatment.


Pancreas carcinoma resectable

Carcinoma of the pancreas amenable to surgical removal.


Pharyngeal cancer recurrent

The reemergence of carcinoma of the pharynx after a period of remission.


malignant spiradenoma

A very rare, aggressive carcinoma of the sweat glands arising from malignant transformation of a long standing spiradenoma. It usually grows in the upper extremities, lower extremities, trunk, and head and neck. It has the tendency to recur and metastasize most often to the lymph nodes, bones, and lungs.


Adult Central Nervous System Neoplasm

A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in adults.  Representative examples of primary neoplasms include astrocytoma, meningioma, pituitary adenoma, and neurilemoma.  Representative examples of tumor metastases from other organs to the central nervous system include lung and breast carcinoma.


Childhood Central Nervous System Neoplasm

A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children.  Representative examples include posterior fossa astrocytoma, optic pathway glioma, medulloblastoma, ependymoma, and craniopharyngioma.


Childhood Glioblastoma

A glioblastoma that occurs during childhood.


Supratentorial Glioblastoma

A glioblastoma that occurs in the supratentorial region.


Cerebellar Glioblastoma

A glioblastoma that occurs in the cerebellum.


Atypical hyperplasia of breast

A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia.


Functional cyst of ovary

A benign ovarian cyst that develops and regresses during the menstrual cycle as part of normal ovarian function.


Stage IA Ovarian Cancer

Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IB Ovarian Cancer AJCC v6 and v7

Stage IB includes: T1b, N0, M0. T1b: Tumor limited to both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IC Ovarian Cancer AJCC v6 and v7

Stage IC includes: T1c, N0, M0. T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIA Ovarian Cancer AJCC V6 and v7

Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or implants on uterus and/or tube(s). No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIB Ovarian Cancer AJCC v6 and v7

Stage IIB includes: T2b N0, M0.  T2b: Extension and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIC Ovarian Cancer AJCC v6 and v7

Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washing.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Childhood Acute Lymphoblastic Leukemia in Complete Remission


Recurrent Meningioma

The reemergence of a meningioma after a period of remission.


Hereditary Paraganglioma

A hereditary neoplasm arising from paraganglia. The majority of cases (up to 80%) are multifocal. It is caused by mutations in SDHA, SDHB, SDHC, SDHD, and SDHAF2 genes.


Secondary Osteosarcoma

An osteosarcoma arising from a pre-existing lesion of the bone, usually Paget disease, or due to radiation therapy.


Adverse Event Associated with Coagulation


Adverse Event Associated with Death

An adverse event resulting in death.


Adverse Event Associated with Growth and Development


Angiosarcoma recurrent

The reemergence of angiosarcoma after a period of remission.


central nervous system primitive neuroectodermal neoplasm

A neuroectodermal tumor that involves the central nervous system.


Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant

A squamous cell carcinoma that arises from the larynx. It is characterized by the presence of a malignant spindle cell cellular component. In some cases, there is a biphasic morphology due to the presence of a well-differentiated squamous cell carcinoma component. The latter is either in situ or invasive squamous cell carcinoma.


Nasopharyngeal Papillary Adenocarcinoma

A low-grade exophytic adenocarcinoma with papillary growth that arises from the epithelium of the nasopharynx. If it is completely removed, the prognosis is excellent.


Intracranial Melanoma

A melanoma that arises from the leptomeninges within the cranium.


Stage IIA Breast Carcinoma

Stage IIA includes: (T0, N1, M0); (T1, N1, M0); (T2, N0, M0).  T0: No evidence of primary tumor.  T1: Tumor 20 mm or less in greatest dimension.  T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension.  N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s).  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  M0 includes M0(i+).  (AJCC 6th and 7th Eds.)


Stage IIB Breast Carcinoma

Stage IIB includes: (T2, N1, M0); (T3, N0, M0).  T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension.  T3: Tumor more than 50 mm in greatest dimension.  N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s).  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  M0 includes M0(i+).  (AJCC 6th and 7th Eds.)


Stage IA Gastric Carcinoma

Stage IA includes: T1, N0, M0.  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Tissue Adhesion

A fibrous band of tissue that connects normally separate body regions.


Stage IB Gastric Carcinoma

Stage IB includes: (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Stage IIIB Gastric Carcinoma

Stage IIIB includes: (T4b, N0, M0); (T4b, N1, M0); (T4a, N2, M0); (T3, N3, M0).  T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Blood Pressure Finding

A test result that reports the diastolic and systolic pressure of the blood.


Stage IIIA Gastric Carcinoma

Stage IIIA includes: (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Grade 1 Hypertension, CTCAE

Adult: Systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg; Pediatric: Systolic/diastolic BP >90th percentile but< 95th percentile; Adolescent: BP >= 120/80 even if < 95th percentile


Erectile Dysfunction, CTCAE

A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.


Stage I Uveal Melanoma AJCC v7

Stage I includes: T1a, N0, M0.  T1a: Iris: Tumor limited to the iris not more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage II Uveal Melanoma AJCC v7

Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Uveal Melanoma AJCC v7

Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC (T4d-e, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IV Uveal Melanoma AJCC v7

Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c).  N1: Regional lymph node metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less.  M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm.  M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.  (AJCC 7th ed.)


Stage I Skin Cancer

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness, Clark level equal or greater than IV, and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


pulmonary coin lesion

A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the chest wall, or the pleura.


Stage II Skin Cancer

Stage II includes: T2, N0, M0.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness; Clark level equal or greater than IV; and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Stage III Skin Cancer

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th Ed.)


Stage IV Skin Cancer

Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T Any, N3, M0); (T4, N Any, M0); (T Any, N Any, M1).  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T4: Tumor with invasion of skeleton or perineural invasion of skull base.  N0: No regional lymph node metastasis.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M1: Distant metastases.  (AJCC 7th Ed.)


Metastatic Anal Canal Carcinoma

An anal canal carcinoma which has spread to another anatomic site.


Adult Acute Lymphoblastic Leukemia in Complete Remission


Carcinoma Metastatic to the Skin

A carcinoma that has spread to the skin from its original site of gowth.


Secondary malignant neoplasm of skin

The spread of a malignant neoplasm to the skin.  This may be from a primary skin malignant neoplasm, or from a malignant neoplasm at a distant site.


Stage IB Lung Cancer AJCC v7

Stage IB includes: T2a, N0, M0.  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IIA Lung Cancer AJCC v7

Stage IIA includes: (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IIB Lung Cancer AJCC v7

Stage IIB includes: (T2b, N1, M0); (T3, N0, M0).  T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension.  T3: Lung cancer with a tumor size more than 7 cm or one that directly invades any of the following: parietal pleural (PL3) chest wall (including superior sulcus tumors), diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium; or tumor in the main bronchus (less than 2 cm distal to the carina but without involvement of the carina); or associated atelectasis or obstructive pneumonitis of the entire lung or separate tumor nodule(s) in the same lobe. N0: No regional lymph node metastasis.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IIIA Lung Cancer AJCC v7

Stage IIIA includes: (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0).  T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe.  N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension.  N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IA Lung Non-Small Cell Carcinoma AJCC v7

Stage IA includes: (T1a, N0, M0); (T1b, N0, M0).  T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.  T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus).  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IB Non-Small Cell Lung Carcinoma AJCC v7


Stage IIB Non-Small Cell Lung Carcinoma AJCC v7


Stage IIA Non-Small Cell Lung Carcinoma AJCC v7


Stage IIA Esophagus Carcinoma

Stage IIA includes: For squamous cell carcinoma: (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X).  For adenocarcinoma: (T2, N0, M0, G3).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Stage IIB Esophageal Carcinoma

Stage IIB includes: For squamous cell carcinoma: (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Stage III Childhood Hepatocellular Carcinoma AJCC v7

Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7

Stage I includes: T1, N0, M0.  T1: Solitary tumor without vascular invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IV Pancreatic Cancer AJCC v6 and v7

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


Stage IVA Gallbladder Cancer AJCC v7

Stage IVA includes: T4, N0-1, M0. T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. M0: No distant metastasis.  (from AJCC 7th Ed.)


Stage IVB Gallbladder Cancer AJCC v7

Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1).  N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


Stage IIIA Hepatocellular Carcinoma AJCC v7

Stage IIIA includes: T3a, N0, M0.  T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IIIB Hepatocellular Carcinoma AJCC v7

Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Hepatocellular Carcinoma AJCC v7

Stage IVA includes: Any T, N1, M0.  N1: Regional lymph node metastasis. M0: No distant metastasis.  (AJCC 7th ed.)


Stage IVB Hepatocellular Carcinoma AJCC v7

Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


Extrahepatic bile duct cancer stage III

Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.)


Rash and Dermatitis Associated with Chemoradiation, CTCAE


Small intestine carcinoma stage III

Stage III includes: IIIA (Any T, N1, M0); IIIB (Any T, N2, M0); N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Small intestine carcinoma stage IV

Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


Metastatic Adult Malignant Neoplasm in the Brain

A malignant neoplasm that has spread from its original site of growth to the brain in an adult patient.


Larynx Edema, CTCAE

Laryngeal edema resulting from a known treatment.


Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Stage IVC Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


Stage IVB Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


Stage IVA Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


Stage IVA Oral Cavity Verrucous Carcinoma


Stage IVB Oral Cavity Verrucous Carcinoma


Stage IVC Oral Cavity Verrucous Carcinoma


Stage IVA Oral Cavity Cancer AJCC v6 and v7


Stage IVB Oral Cavity Cancer AJCC v6 and v7


Stage IVC Oral Cavity Cancer AJCC v6 and v7


Stage I Major Salivary Gland Cancer AJCC v7

Stage I includes: T1, N0, M0.  T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage II Major Salivary Gland Cancer AJCC v7

Stage II includes: T2, N0, M0. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Stage III Major Salivary Gland Cancer AJCC v7

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.  Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension. T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IV Major Salivary Gland Cancer AJCC v7

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N, M1). T4a: Moderately advanced disease.  Tumor invades skin, mandible, ear canal, and/or facial nerve. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal extension.  Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.  T2: Tumor measuring more than 2 cm, but not more than 4 cm in greatest dimension without extraparenchymal extension.  T3: Tumor measuring more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.  T4b: Very advanced disease.  Tumor invades skull base and/or pterygoid plates and/or encases carotid artery. N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


Thoracic Duct Intra-Operative Injury, CTCAE


Oral Cavity Mucosal Melanoma

A rare melanoma that arises from the oral cavity. It is associated with a poor prognosis.


Stage IIIB Anal Canal Cancer AJCC v6 and v7

Stage IIIB includes: (T4, N1, M0); (Any T, N2, M0); (Any T, N3, M0). T4: Tumor of any size that invades adjacent organ(s).  N1: Metastasis in perirectal lymph node(s).  N2: Metastasis in unilateral internal iliac and/or inguinal lymph node(s).  N3: Metastasis in perirectal and inguinal lymph nodes and/or bilateral internal iliac and/or inguinal lymph nodes. M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Stage IVA Oropharyngeal Carcinoma AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Tumor with moderately advanced local disease.  Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible.  Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.  (AJCC 7th ed.)


Stage IVB Oropharyngeal Carcinoma AJCC v7

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0). T4b: Tumor with very advanced local disease.  Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N3: Tumor with metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVC Nasopharyngeal Carcinoma AJCC v7


Stage IVB Nasopharyngeal Carcinoma AJCC v7

Stage IVB includes: Any T, N3, M0.  N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa.  Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho.  It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder.  This would include caudal portions of levels IV and VB.  All cases with lymph nodes (whole or part) in the fossa are considered N3b.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Nasopharyngeal Carcinoma AJCC v7

Stage IVA includes: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVA Pharyngeal Carcinoma

Stage IVA carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Stage IVB Pharyngeal Carcinoma

Stage IVB carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Stage IVC Pharyngeal Carcinoma

Stage IVC carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7

Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Squamous cell carcinoma of the oral cavity stage I

Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Squamous cell carcinoma of the oral cavity stage II

Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Squamous cell carcinoma of the oral cavity stage III

Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Squamous cell carcinoma of the oral cavity stage IV

Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Squamous cell carcinoma of the oral cavity recurrent

Reemergence of squamous cell carcinoma of the oral cavity after a period of remission.


Somatostatin-Positive Neoplastic Cells Present


White Spot Lesion

A chalky white area that appears on a tooth surface indicating the presence of decalcified enamel and the potential to advance to cavitation.


Dental Plaque

A biofilm that contains numerous microorganisms that adheres to the teeth.


Recurrent Oral Cavity Carcinoma

The reemergence of carcinoma in the oral cavity after a period of remission.


Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7

Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Supraglottis: Moderately advanced local disease.  Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). Subglottis: Moderately advanced local disease.  Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Severe Aplastic Anemia

Life-threatening anemia associated with a high risk of infection or bleeding.


Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7

Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Supraglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Glottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Subglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)