Locally Advanced Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction adenocarcinoma that has spread to nearby tissues or lymph nodes.


Metastatic Papillary Renal Cell Carcinoma

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A papillary renal cell carcinoma that has spread from the original site of growth to another anatomic site.


Advanced Papillary Renal Cell Carcinoma

A papillary renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Myxoid Liposarcoma

A myxoid liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Colorectal Carcinoma

A colorectal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Gastric Adenocarcinoma

A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Clear-cell metastatic renal cell carcinoma

A clear cell renal cell carcinoma that has spread from its original site of growth to other anatomic sites.


Locally Advanced Gastric Carcinoma

A gastric carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Higher Risk Myelodysplastic Syndrome

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Myelodysplastic syndrome with a score of INT-2 (intermediate-2) or higher (the category above INT-2).


Localized Breast Carcinoma

Breast carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Unresectable Merkel Cell Carcinoma

Merkel cell carcinoma that is not amenable to surgical resection.


Resectable Oropharyngeal Squamous Cell Carcinoma

Oropharyngeal squamous cell carcinoma that is amenable to surgical resection.


Unresectable Oropharyngeal Squamous Cell Carcinoma

Oropharyngeal squamous cell carcinoma that is not amenable to surgical resection.


Gastrointestinal dysfunction

A finding of any disturbance, impairment, or abnormality of function of the gastrointestinal system.


Locally Advanced Oropharyngeal Squamous Cell Carcinoma

An oropharyngeal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastatic Sinonasal Squamous Cell Carcinoma

Nasal cavity and/or paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


cell-associated neurotoxicity

Neurotoxicity associated with immune effector cell therapy. It may be characterized by aphasia, altered level of consciousness, motor weakness, seizures, and cerebral edema.


Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck

The reemergence of cutaneous squamous cell carcinoma of the head and neck after a period of remission.


Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that is amenable to surgical resection.


Malignant glioma of brain

A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma).


Non-Malignant Neoplasm

A category that includes benign neoplasms and neoplasms with uncertain malignant potential. The latter are characterized by clinicopathological features that are not benign, including some degree of mild or mild/moderate atypia/dysplasia, but lack overt malignant morphologic characteristics and there is no evidence of metastasis at the time of diagnosis.


Unresectable Meningioma

A meningioma that is not amenable to surgical resection.


Brain Lesion

A localized pathological or traumatic structural change, damage, deformity, or discontinuity of the brain.


Advanced Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Ureter Urothelial Carcinoma

Ureter urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Urethral Urothelial Carcinoma

A urethral urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Thyroid Gland Medullary Carcinoma

Thyroid gland medullary carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Dedifferentiated Liposarcoma

Dedifferentiated liposarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma that is not amenable to surgical resection.


Advanced Genitourinary System Carcinoma

A genitourinary system carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Fumarate Hydratase-Deficient Renal Cell Carcinoma

A rare, highly aggressive renal cell carcinoma caused by germline or (in a subset) somatic mutation of fumarate hydratase gene. It arises mostly in the setting of hereditary leiomyomatosis-renal cell carcinoma syndrome.


Surgical Complication

A disease or disorder that occurs during, soon after or as a result of a surgical procedure.


Post-Surgical Complication

A disease or disorder that occurs soon after or as a result of a surgical procedure.


Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma

Renal pelvis and ureter urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


NRG1 Gene Fusion Positive

An indication that the expression of a fusion containing sequences derived from the NRG1 gene has been detected in a sample.


Advanced Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Renal Function

Pertaining to the physiologic processes of the kidneys.


Invasive Sarcomatoid Urothelial Carcinoma

An invasive urothelial carcinoma that exhibits spindle cell sarcomatoid features.


Mixed neuroendocrine-non neuroendocrine neoplasm

A rare neoplasm that consists of neuroendocrine and non-neuroendocrine cellular components. At least 30% of either component should be present for the diagnosis to be made.


Unresectable Malignant Peripheral Nerve Sheath Tumor

A malignant peripheral nerve sheath tumor that is not amenable to surgical resection.


Unresectable Liver and Intrahepatic Bile Duct Carcinoma

Liver carcinoma that is not amenable to surgical resection.


Unresectable Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma that is not amenable to surgical resection.


Soft Tissue Sarcoma of the Trunk and Extremities

A soft tissue sarcoma that arises from the trunk or the extremities.


Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

The reemergence of diffuse large B-cell lymphoma, not otherwise specified after a period of remission.


Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


Primary Peritoneal Endometrioid Adenocarcinoma

An exceedingly rare endometrioid adenocarcinoma arising from the peritoneum.


Recurrent Ovarian High Grade Serous Adenocarcinoma

The reemergence of ovarian high-grade serous adenocarcinoma after a period of remission.


Recurrent Fallopian Tube Endometrioid Adenocarcinoma

The reemergence of fallopian tube endometrioid adenocarcinoma after a period of remission.


Recurrent Fallopian Tube High Grade Serous Adenocarcinoma

The reemergence of fallopian tube high-grade serous adenocarcinoma after a period of remission.


Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma

The reemergence of primary peritoneal high-grade serous adenocarcinoma after a period of remission.


Recurrent Primary Peritoneal Endometrioid Adenocarcinoma

The reemergence of primary peritoneal endometrioid adenocarcinoma after a period of remission.


Recurrent Endometrial Dedifferentiated Carcinoma

The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


Recurrent Moderate-Severe Chronic Graft Versus Host Disease

The reemergence of moderate-severe chronic graft versus host disease after a period of remission.


Refractory Endometrial Adenocarcinoma

Endometrial adenocarcinoma that is resistant to treatment.


Resectable Liver and Intrahepatic Bile Duct Carcinoma

Liver carcinoma that is amenable to surgical resection.


Very High Risk Myelodysplastic Syndrome

Myelodysplastic syndrome with more than 6 points, according to the revised International Prognostic Scoring System (IPSS-R).


Refractory Endometrial Undifferentiated Carcinoma

Endometrial undifferentiated carcinoma that is resistant to treatment.


Advanced gastric carcinoma

Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Advanced Merkel Cell Carcinoma

A Merkel cell carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Metastatic Pancreatic Neuroendocrine Neoplasm

A pancreatic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Unresectable Clear Cell Renal Cell Carcinoma

A clear cell renal cell carcinoma that is not amenable to surgical resection.


Advanced Pancreatic Carcinoma

Pancreatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Lung Neuroendocrine Neoplasm

A lung neuroendocrine neoplasm that is not amenable to surgical resection.


Unresectable Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that is not amenable to surgical resection.


Unresectable Pancreatic Neuroendocrine Neoplasm

A pancreatic neuroendocrine neoplasm that is not amenable to surgical resection.


Advanced Ovarian Carcinoma

An ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Oral Cavity Squamous Cell Carcinoma

Oral cavity squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Laryngeal Squamous Cell Carcinoma

Laryngeal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Arsenical keratosis

A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic.


Arsenic Exposure

A finding indicating that an individual has been exposed to arsenic.


Transthyretin amyloid cardiomyopathy

Cardiomyopathy resulting from the deposition of misfolded transthyretin. The condition can be classified by the presence (hereditary transthyretin amyloid) or absence (wild-type transthyretin amyloid) of mutation(s) in the TTR gene, encoding transthyretin.


Unresectable Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that is not amenable to surgical resection.


Environmental Exposure

Exposure to potentially harmful chemical, physical, or biological agents via the environment.


Coronary Slow Flow Phenomenon

An angiographic finding characterized by delayed progression of contrast medium into distal epicardial vessels in the absence of significant coronary artery disease.


Unresectable Acral Lentiginous Melanoma

Acral lentiginous melanoma that is not amenable to surgical resection.


Unresectable Mucosal Melanoma

Mucosal melanoma that is not amenable to surgical resection.


Chronic Disease

A disease condition that persists over a significant span of time.


Refractory Differentiated Thyroid Gland Carcinoma

Differentiated thyroid gland carcinoma that is resistant to treatment.


Refractory Thyroid Gland Papillary Carcinoma

Thyroid gland papillary carcinoma that is resistant to treatment.


Refractory Thyroid Gland Follicular Carcinoma

Thyroid gland follicular carcinoma that is resistant to treatment.


Refractory Thyroid Gland Oncocytic Carcinoma

Thyroid gland oncocytic carcinoma that is resistant to treatment.


Recurrent Differentiated Thyroid Gland Carcinoma

The reemergence of differentiated thyroid gland carcinoma after a period of remission.


Breast adenocarcinoma metastatic

An adenocarcinoma that arises from the breast and has metastasized to another anatomic site.


Locally Advanced Hypopharyngeal Squamous Cell Carcinoma

Hypopharyngeal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Refractory Bladder Urothelial Carcinoma

Bladder urothelial carcinoma that does not respond to treatment.


Invasive Bladder Mixed Carcinoma

An invasive bladder carcinoma characterized by the presence of more than one histologic pattern.


Refractory Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that does not respond to treatment.


Locally Advanced Merkel Cell Carcinoma

A Merkel cell carcinoma that has spread to nearby tissues or lymph nodes.


Refractory Merkel Cell Carcinoma

Merkel cell carcinoma that does not respond to treatment.


Hormone Receptor-Negative Breast Carcinoma

Breast adenocarcinoma that is negative for hormone receptors.


Refractory Renal Cell Carcinoma

Renal cell carcinoma that does not respond to treatment.


Resectable Lung Non-Small Cell Carcinoma

Lung non-small cell carcinoma that is amenable to surgical resection.


Second Primary Squamous Cell Carcinoma of the Head and Neck

A finding indicating the occurrence of a primary head and neck squamous cell carcinoma following the diagnosis of an initial primary squamous cell carcinoma in the head and neck.


Advanced Leiomyosarcoma

A leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Undifferentiated Pleomorphic Sarcoma

An undifferentiated pleomorphic sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Transformed Mycosis Fungoides

Histologic transformation of mycosis fungoides to an aggressive non-Hodgkin lymphoma.


Recurrent Transformed Mycosis Fungoides

The reemergence of transformed mycosis fungoides after a period of remission.


Refractory Transformed Mycosis Fungoides

Transformed mycosis fungoides that is resistant to treatment.


Recurrent Myeloproliferative Neoplasm

The reemergence of a myeloproliferative neoplasm after a period of remission.


The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission.


Metastatic Primary Malignant Central Nervous System Neoplasm

A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to other sites.


Locally Advanced Primary Malignant Central Nervous System Neoplasm

A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Gastric Adenocarcinoma

Gastric adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Esophageal Adenocarcinoma

Esophageal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Colorectal Adenocarcinoma

Colorectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Sinonasal Mucosal Melanoma

Melanoma that arises from the mucosal surface of the nasal cavity and paranasal sinus.


Metastatic rhabdomyosarcoma

Rhabdomyosarcoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Bladder Carcinoma

A bladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Ovarian Carcinoma

Ovarian carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Ovarian Carcinoma

Ovarian carcinoma that is not amenable to surgical resection.


Unresectable Bladder Carcinoma

Bladder carcinoma that is not amenable to surgical resection.


Refractory Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that is resistant to treatment.


BRCA-Associated Malignant Neoplasm

A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family.


BRCA-Associated Breast Carcinoma

Breast carcinoma caused by deleterious germline mutation in a gene of the BRCA family.


PALB2-Associated Breast Carcinoma

Breast carcinoma caused by deleterious germline mutation in the PALB2 gene.


Metastatic Primary Peritoneal Carcinoma

A carcinoma that arises from the peritoneum and has metastasized to another anatomic site.


Metastatic Nasal Cavity Squamous Cell Carcinoma

Nasal cavity squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Advanced Colon Carcinoma

Colon carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Prostate Carcinoma

Prostate carcinoma that is resistant to treatment.


Advanced Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Nasopharyngeal squamous cell carcinoma recurrent

The reemergence of squamous cell carcinoma of the nasopharynx after a period of remission.


Locally Advanced Pancreatic Neuroendocrine Tumor

A pancreatic neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Midgut Neuroendocrine Tumor

A neuroendocrine tumor that arises from the jejunum, ileum, proximal colon, or appendix.


Metastatic Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Unresectable Midgut Neuroendocrine Tumor

A midgut neuroendocrine tumor that is not amenable to surgical resection.


Locally Advanced Neuroendocrine Neoplasm

A neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Hepatocellular Carcinoma

Hepatocellular carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Bladder Carcinoma

A bladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Nasopharyngeal Squamous Cell Carcinoma

Nasopharyngeal squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


Endocrine mucin-producing sweat gland carcinoma

A rare, low-grade sweat gland carcinoma with neuroendocrine differentiation. It usually arises on the eyelids and periorbital skin. It affects mostly older individuals. Women are affected more frequently than men. Morphologically, it is characterized by well-demarcated nodules with cystic, papillary, or cribriform architectural patterns. The neoplastic cells are small to intermediate polygonal to round cells. Small amounts of intracellular or extracellular mucin are present. In some cases, this carcinoma is a precursor of mucinous carcinoma.


Advanced Epithelioid Sarcoma

Epithelioid sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Fallopian Tube Carcinoma

Fallopian tube carcinoma that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Advanced Primary Peritoneal Carcinoma

Primary peritoneal carcinoma that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Abnormal Echocardiogram

A history of having had an abnormal echocardiogram.


Chronic Orthostatic Intolerance

A condition in which there is orthostatic intolerance lasting for at least three months with associated functional impairment. (ACC/AHA)


Myopathy Secondary to Fatty Acid Oxidation Disorder

A myopathy that was caused by a primary disorder of fatty acid oxidation.


Secondary pulmonary hypertension

Pulmonary hypertension that is caused by an underlying condition.


Neonatal Complication

A difficulty or problem that occurs at or just after delivery of an infant that can jeopardize the health of the infant.


Locally Advanced Thyroid Gland Medullary Carcinoma

Thyroid gland medullary carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Differentiated Thyroid Gland Carcinoma

Differentiated thyroid gland carcinoma that is not amenable to surgical resection.


Steroid Resistant Acute Graft Versus Host Disease

Acute graft versus host disease that is resistant to treatment with steroids.


Metastatic Myxofibrosarcoma

Myxofibrosarcoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Myxofibrosarcoma

Myxofibrosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


High Risk Prostate Carcinoma

Prostate carcinoma with clinicopathologic, cytogenetic, and molecular findings that define a prostate carcinoma as high risk.


Very High Risk Prostate Carcinoma

Prostate carcinoma with clinicopathologic, cytogenetic, and molecular findings that define a prostate carcinoma as very high risk.


High Risk Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia with clinicopathologic, cytogenetic, and molecular findings that define an acute lymphoblastic leukemia as high risk.


Advanced Dedifferentiated Liposarcoma

A dedifferentiated liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


An epithelioid hemangioendothelioma that is not amenable to surgical resection.


Metastatic HER2-Negative Breast Carcinoma

A HER2-negative breast adenocarcinoma that has spread to another anatomic site.


Recurrent Follicular Helper T-Cell Lymphoma

The reemergence of follicular helper T-cell lymphoma after a period of remission.


Refractory Follicular Helper T-Cell Lymphoma

Follicular helper T-cell lymphoma that is resistant to treatment.


Recurrent Follicular Helper T-Cell Lymphoma, Follicular-Type

The reemergence of follicular helper T-cell lymphoma, follicular-type after a period of remission.


Refractory Follicular Helper T-Cell Lymphoma, Follicular-Type

Follicular helper T-cell lymphoma, follicular-type that is resistant to treatment.


Advanced HER2-Negative Breast Carcinoma

A HER2-negative breast adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory HER2-Negative Breast Carcinoma

A HER2-negative breast adenocarcinoma that is resistant to treatment.


Locally Advanced Esophageal Carcinoma

Esophageal carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Adenocarcinoma

Adenocarcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Hepatocellular Carcinoma

Hepatocellular carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Pancreatic Carcinoma

A pancreatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Cholangiocarcinoma

Cholangiocarcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Renal Cell Carcinoma

Renal cell carcinoma that has spread to nearby tissues or lymph nodes.


Platinum-Resistant Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that progresses between one and six months of completing platinum therapy.


Localized Pancreatic Adenocarcinoma

An adenocarcinoma that arises from the pancreas and has not spread to other anatomic sites.


Metastatic Choroid Melanoma

Choroid melanoma that has spread from its primary site to another anatomic site.


Metastatic Mucosal Melanoma

Mucosal melanoma that has spread from its primary site to another anatomic site.


Locally Advanced Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma that has spread to nearby tissues or lymph nodes.


Recurrent Anal Squamous Cell Carcinoma

The reemergence of anal squamous cell carcinoma after a period of remission.


Anal squamous cell carcinoma metastatic

Anal squamous cell carcinoma that has spread from its primary site to another anatomic site.


Occupational Exposure

The exposure to potentially harmful agents that occurs as a result of one's occupation.


Locally Advanced Endometrial Carcinoma

Endometrial carcinoma that has spread to nearby tissues or lymph nodes.


Resectable Skin Squamous Cell Carcinoma

Skin squamous cell carcinoma that is amenable to surgical resection.


Diminished mental function after chemotherapy.


Recurrent Platinum-Resistant Ovarian Carcinoma

The reemergence of platinum-resistant ovarian carcinoma after a period of remission.


Recurrent Platinum-Resistant Fallopian Tube Carcinoma

The reemergence of platinum-resistant fallopian tube carcinoma after a period of remission.


Recurrent Platinum-Resistant Primary Peritoneal Carcinoma

The reemergence of platinum-resistant primary peritoneal carcinoma after a period of remission.


Recurrent Ovarian Undifferentiated Carcinoma

The reemergence of ovarian undifferentiated carcinoma after a period of remission.


Recurrent Fallopian Tube Undifferentiated Carcinoma

The reemergence of fallopian tube undifferentiated carcinoma after a period of remission.


Recurrent Primary Peritoneal Undifferentiated Carcinoma

The reemergence of primary peritoneal undifferentiated carcinoma after a period of remission.


Recurrent Fallopian Tube Transitional Cell Carcinoma

The reemergence of fallopian tube transitional cell carcinoma after a period of remission.


Recurrent Primary Peritoneal Transitional Cell Carcinoma

The reemergence of primary peritoneal transitional cell carcinoma after a period of remission.


Recurrent Fallopian Tube Clear Cell Adenocarcinoma

The reemergence of fallopian tube clear cell adenocarcinoma after a period of remission.


Recurrent Primary Peritoneal Clear Cell Adenocarcinoma

The reemergence of primary peritoneal clear cell adenocarcinoma after a period of remission.


Recurrent Fallopian Tube Adenocarcinoma

The reemergence of fallopian tube adenocarcinoma after a period of remission.


Recurrent Primary Peritoneal Adenocarcinoma

The reemergence of primary peritoneal adenocarcinoma after a period of remission.


Non-Muscle Invasive Bladder Urothelial Carcinoma

An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria.


Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma

The reemergence of non-muscle invasive bladder urothelial carcinoma after a period of remission.


Advanced Rectal Carcinoma

Rectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Rectal Carcinoma

Rectal carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Oropharyngeal Carcinoma

Oropharyngeal carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Vulvar Carcinoma

Vulvar carcinoma that has spread to nearby tissues or lymph nodes.


Advanced Vulvar Carcinoma

Vulvar carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vaginal Carcinoma

Vaginal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Penile Carcinoma

Penile carcinoma that has spread to nearby tissues or lymph nodes.


Advanced Penile Carcinoma

Penile carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Endometrial Endometrioid Adenocarcinoma

An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites.


Metastatic Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread to other anatomic sites.


Advanced Malignant Skin Neoplasm

A malignant neoplasm of the skin that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Thyroid Gland Anaplastic Carcinoma

Thyroid gland anaplastic carcinoma that has spread from the original site of growth to another anatomic site.


Refractory Myeloproliferative Neoplasm

A myeloproliferative neoplasm that does not respond to treatment.


Advanced Ovarian Clear Cell Adenocarcinoma

Ovarian clear cell adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Chondrosarcoma

Chondrosarcoma that has spread to nearby tissues or lymph nodes.


Recurrent Mucosal Melanoma

The reemergence of a mucosal melanoma after a period of remission.


Locally Advanced Thyroid Gland Carcinoma

Thyroid gland carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Fallopian Tube Carcinoma

Fallopian tube carcinoma that is not amenable to surgical resection.


Unresectable Primary Peritoneal Carcinoma

Primary peritoneal carcinoma that is not amenable to surgical resection.


Advanced Glioblastoma

Glioblastoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adenocarcinoma of the prostate recurrent

The reemergence of prostate adenocarcinoma after a period of remission.


Supratentorial Gliosarcoma

A gliosarcoma arising from the supratentorial region.


Recurrent Triple-Negative Breast Carcinoma

The reemergence of triple-negative breast carcinoma after a period of remission.


Refractory Ovarian Serous Adenocarcinoma

Ovarian serous adenocarcinoma that is resistant to treatment.


Metastatic Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that has spread from its original site of growth to other anatomic sites.


Unresectable Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that is not amenable to surgical resection.


Metastatic Primary Peritoneal Serous Adenocarcinoma

Primary peritoneal serous adenocarcinoma that has spread from its original site of growth to another anatomic site.


Unresectable Primary Peritoneal Serous Adenocarcinoma

Primary peritoneal serous adenocarcinoma that is not amenable to surgical resection.


Refractory Primary Peritoneal Serous Adenocarcinoma

Primary peritoneal serous adenocarcinoma that is resistant to treatment.


Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma

A squamous cell carcinoma associated with human papilloma virus, arising from the mucosal sites of head and neck.


Visceral Angiosarcoma

A soft tissue angiosarcoma arising from the internal organs.


Recurrent Hairy Cell Leukemia Variant

The reemergence of hairy cell leukemia variant after a period of remission.


Unresectable Primary Central Chondrosarcoma

Primary central chondrosarcoma that is not amenable to surgical resection.


Metastatic Primary Central Chondrosarcoma

Primary central chondrosarcoma that has spread from its original site of growth to other anatomic sites.


Cutaneous lymphoma

A lymphoma involving the skin.


Bacterial Colonization

The detection of bacteria in or on an anatomic site, medical device or biospecimen.


Ann Arbor Stage IIX (Bulky) Diffuse Large B-Cell Lymphoma

Ann Arbor Stage II diffuse large B-cell lymphoma with a mass of nodes with one diameter more than 10cm or a mediastinal mass larger than one third of the transthoracic width. (Cotswolds modification)


Thoracic Injuries

Trauma to the chest.


Oligometastatic Prostate Carcinoma

Prostate carcinoma that has metastasized to a limited number of sites.


Locally Advanced Hypopharyngeal Carcinoma

Hypopharyngeal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Cutaneous Melanoma

Cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastatic ocular melanoma

Ocular melanoma that has spread from its original site of growth to another anatomic site.


A myelodysplastic/myeloproliferative neoplasm that is resistant to treatment.


Refractory Primary Myelofibrosis

Primary myelofibrosis that is resistant to treatment.


Passive Smoke Exposure

Exposure to tobacco smoke products among individuals who do not smoke. This can result from sharing space with a smoker or from placental transfer from mother to fetus.


Pandemic Disorder

An epidemic occurring worldwide, or over a very wide area, crossing international boundaries, and usually affecting a large number of people. (A dictionary of epidemiology, edited for the International Epidemiological Association by John M. Last, Oxford University Press 2001)


Aggressive Variant Prostate Carcinoma

A lethal form of advanced castration-resistant prostate carcinoma that emerges in the later stages of castration-resistant treatment. It is an adaptive response to androgen receptor pathway inhibition. The morphologic features vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small cell carcinomas to pure small cell carcinomas expressing neuroendocrine markers. Clinically, it manifests with rapidly progressive disease, visceral or lytic bone metastases and bulky tumor masses. Molecular studies have shown the loss of tumor suppressor genes TP53 and RB1.


Metastatic Chromophobe Renal Cell Carcinoma

Chromophobe renal cell carcinoma that has spread from the original site of growth to another anatomic site.


Advanced Sarcomatoid Renal Cell Carcinoma

Sarcomatoid renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Unclassified Renal Cell Carcinoma

A renal cell carcinoma, not otherwise specified, that has spread from the original site of growth to another anatomic site.


Advanced Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment


Unresectable Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Endometrial Carcinoma

Endometrial carcinoma that is not amenable to surgical resection.


SLFN11 Positive

An indication that SLFN11 expression has been detected in a sample.


Limb fracture

A traumatic break in one or more bones in a limb.


Restenosis

The reoccurrence of stenosis after it has been treated.


Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm

An acute myeloid leukemia developing in patients with a prior history of myeloproliferative neoplasm.


Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic/myeloproliferative neoplasm.


Locally Advanced Papillary Renal Cell Carcinoma

Papillary renal cell carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Esophageal Adenocarcinoma

Esophageal adenocarcinoma that has spread to nearby tissues or lymph nodes.


Unresectable Distal Bile Duct Adenocarcinoma

Distal bile duct adenocarcinoma that is not amenable to surgical resection.


Metastatic Distal Bile Duct Adenocarcinoma

Distal bile duct adenocarcinoma that has spread from its original site of growth to another anatomic site.


Unresectable Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma that is not amenable to surgical resection.


Unresectable Uveal Melanoma

Uveal melanoma that is not amenable to surgical resection.


Intrahepatic cholangiocarcinoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Renal Pelvis Carcinoma

Renal pelvis carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Renal Pelvis Urothelial Carcinoma

Renal pelvis urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Myeloid Neoplasm

A myeloid neoplasm that does not respond to treatment.


Refractory Grade 1 Follicular Lymphoma

Grade 1 follicular lymphoma that is resistant to treatment.


Cat allergy (disorder)

An allergic reaction triggered by exposure to allergens expressed by cats, includes allergenic factors found in feline saliva and dander.


Refractory Grade 2 Follicular Lymphoma

Grade 2 follicular lymphoma that is resistant to treatment.


Egg allergy

Hypersensitivity in form of an adverse immune reaction against eggs.


Refractory Grade 3 Follicular Lymphoma

Grade 3 follicular lymphoma that is resistant to treatment.


Refractory Grade 3a Follicular Lymphoma

Grade 3a follicular lymphoma that is resistant to treatment.


Refractory Grade 3b Follicular Lymphoma

Grade 3b follicular lymphoma that is resistant to treatment.


Recurrent Grade 3b Follicular Lymphoma

The reemergence of grade 3b follicular lymphoma after a period of remission.


Locally Advanced Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Follicular Lymphoma

Follicular lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Hodgkin Lymphoma

Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Severe Acute Respiratory Distress Syndrome

A form of acute respiratory distress syndrome (ARDS) that is marked by severe hypoxemia. Based on the Berlin criteria, onset must occur within one week of a clinical insult or there must be evidence of new or worsening respiratory symptoms. Chest imaging reveals bilateral opacities consistent with pulmonary edema that are not fully explained by effusions, lobar/lung collapse, or nodules. Respiratory failure is not fully explained by heart failure or fluid overload and objective assessment, e.g. echocardiography, is required to exclude hydrostatic edema if no risk factor is present. Additionally, oxygenation as measured by a partial pressure of arterial oxygen (PaO2) to the fraction of inspired oxygen (FIO2) is equivalent to 100 mm Hg or less with positive end-expiratory pressure (PEEP) of at least 5 cm of water (Ranieri VM et al., JAMA. 2012;307(23):2526-2533). Severe ARDS may be associated with cytokine release syndrome.


Recurrent Acute Leukemia of Ambiguous Lineage

The reemergence of acute leukemia of ambiguous lineage after a period of remission.


Refractory Acute Leukemia of Ambiguous Lineage

Acute leukemia of ambiguous lineage that is resistant to treatment.


Unresectable Oral Cavity Squamous Cell Carcinoma

Oral cavity squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Laryngeal Squamous Cell Carcinoma

Laryngeal squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Hypopharyngeal Squamous Cell Carcinoma

Hypopharyngeal squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Salivary Gland Squamous Cell Carcinoma

Salivary gland squamous cell carcinoma that is not amenable to surgical resection.


silent stroke

An asymptomatic cerebral infarction that was incidentally noted by T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensities on an MRI of the brain.


High Grade Anal Intraepithelial Neoplasia

Anal canal or perianal skin intraepithelial neoplasia with moderate or severe dysplasia.


Macrotrabecular Massive Hepatocellular Carcinoma

Hepatocellular carcinoma characterized by more than 50% growth of macrotrabecular pattern (equal to or more than 6 to 10 cells thick). It presents with higher grade and stage compared to conventional hepatocellular carcinoma. It has poor prognosis with early recurrence and poor overall survival.


Unresectable Neuroendocrine Carcinoma

Neuroendocrine carcinoma that is not amenable to surgical resection.


Refractory Indolent Non-Hodgkin Lymphoma

Indolent non-Hodgkin lymphoma that is resistant to treatment.


Unresectable Anal Squamous Cell Carcinoma

Anal squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Esophageal Adenocarcinoma

Esophageal adenocarcinoma that is not amenable to surgical resection.


Microsatellite Stable Colorectal Carcinoma

Colorectal carcinoma characterized by the absence of microsatellite instability.


Advanced Gastrointestinal Stromal Tumor

A gastrointestinal stromal tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Acute Undifferentiated Leukemia

Acute undifferentiated leukemia that does not respond to treatment.


Hematoma of rectus sheath

A collection of blood in the rectus sheath due to disruption of the superior or inferior epigastric arteries, which may present following direct trauma to the rectus abdominis muscle or anticoagulation therapy.


Endocrine Therapy-Induced Alopecia

Alopecia caused by treatment with endocrine therapy agents.


Transfusion dependent thalassaemia

Thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


Transfusion Dependent Beta Thalassemia

Beta thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


Salivary Gland Poorly Differentiated Carcinoma

A high-grade carcinoma that arises from the salivary glands. This category includes large and small cell types with or without neuroendocrine differentiation.


Refractory Acute Biphenotypic Leukemia

Acute biphenotypic leukemia that is resistant to treatment.


Metastatic Pharyngeal Squamous Cell Carcinoma

Pharyngeal squamous cell carcinoma that has spread from the original site of growth to another anatomic site.


Recurrent Pharyngeal Squamous Cell Carcinoma

The reemergence of pharyngeal squamous cell carcinoma after a period of remission.


Severe acute respiratory infection

A respiratory infectious disorder that leads to an acute illness that requires medical attention.


Fibrinolysis Shutdown

Acute impairment of breaking down fibrin clots leading to venous thromboembolism, stroke, and renal failure.


Very Severe Aplastic Anemia

Aplastic anemia that is characterized by bone marrow (BM) cellularity less than 25% (or less than 50% if BM is comprised of less than 30% hematopoietic cells), and two or more of the following: absolute neutrophil count of less than 200 per microliter; platelet count of less than 20,000 per microliter; or an absolute reticulocyte count of less than 20,000 per microliter.


Non-Severe Aplastic Anemia

Aplastic anemia that is characterized by bone marrow cellularity less than 30% and does not meet criteria for severe aplastic anemia.


Locally Advanced Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Recurrent Ectomesenchymoma

The reemergence of ectomesenchymoma after a period of remission.


Bilateral Thalamic Glioma

A glioma affecting both sides of the thalamus.


Esophageal anastomotic stricture

Luminal narrowing at the site of surgical resection and reconstruction of the esophagus.


Metastatic Differentiated Thyroid Gland Carcinoma

Differentiated thyroid gland carcinoma that has spread from its original site of growth to another anatomic site.


Advanced Differentiated Thyroid Gland Carcinoma

Differentiated thyroid gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Cervical Carcinoma

Cervical carcinoma that is not amenable to surgical resection.


Advanced Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Cervical Adenosquamous Carcinoma

Cervical adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Salivary Gland Carcinoma

Salivary gland carcinoma that is not amenable to surgical resection.


Refractory AL Amyloidosis

AL amyloidosis that does not respond to treatment.


Locally Advanced Rectal Adenocarcinoma

Rectal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


acute myeloid leukemia, MLL gene rearrangement

Any acute myeloid leukemia that has the chromosomal anomaly MLL gene rearrangement. (A molecular abnormality indicating rearrangement of the MLL (KMT2A) gene.)


Recurrent Supratentorial Glioblastoma

The reemergence of supratentorial glioblastoma after a period of remission.


Locally Advanced Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Chronic inflammation

An inflammatory process characterized by the presence of lymphocytes and plasma cells and the absence of polymorphonuclear neutrophils.


Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections.


Resectable Pancreatic Adenosquamous Carcinoma

Pancreatic adenosquamous carcinoma that is amenable to surgical resection.


Metastatic Thyroid Gland Oncocytic Carcinoma

Thyroid gland oncocytic carcinoma that has spread from its original site of growth to another anatomic site.


Incidental Gallbladder Carcinoma

Gallbladder carcinoma that is discovered incidental to gallbladder surgery for another indication.


Recurrent Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma, after a period of remission.


Refractory Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma and is resistant to treatment.


Advanced Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Vaginal Carcinoma

Vaginal carcinoma that is not amenable to surgical resection.


Recurrent Acral Lentiginous Melanoma

The reemergence of acral lentiginous melanoma after a period of remission.


Advanced Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Primary Malignant Brain Neoplasm

A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites.


Breast adenocarcinoma recurrent

The reemergence of breast adenocarcinoma after a period of remission.


Locally Advanced Osteosarcoma

Osteosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Refractory Desmoid Fibromatosis

Desmoid fibromatosis that is resistant to treatment.


Vitreoretinal Disorder

A disorder affecting the vitreous fluid and retina.


hypercholesterolemia, autosomal dominant, type B

An autosomal dominant condition caused by mutation(s) in the APOB gene, encoding apolipoprotein B-100. It is characterized by hypercholesterolemia and abnormal low-density lipoproteins.


Unresectable Biliary Tract Carcinoma

Biliary tract carcinoma that is not amenable to surgical resection.


Recurrent Low Grade Astrocytoma

The reemergence of a low grade astrocytoma after a period of remission.


Localized Prostate Carcinoma

A carcinoma that arises from the prostate and has not spread to other anatomic sites.


Immune Dysregulation Disorder

A group of autoimmune disorders characterized by defects in self-tolerance (central or peripheral) resulting in autoimmune disease with or without recurrent infections, comprised by: Familial hemophagocytic lymphohistiocytosis (FHL) syndromes; FHL syndromes with hypopigmentation; Regulatory T cell (Treg) defects (eg, IPEX); Autoimmunity with or without lymphoproliferation (eg, autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy [APECED]); Autoimmune lymphoproliferative syndrome (ALPS); Immune dysregulation with colitis; and Susceptibility to Epstein-Barr virus (EBV) and lymphoproliferative conditions.


Primary Immune Regulatory Disorder

A group of immune diseases characterized predominantly by immune dysregulation leading to organ-specific autoimmunity, excessive inflammation, and non-malignant lymphoproliferation. Unlike classical primary immunodeficiencies, susceptibility to infections is typically less prominent in these disorders.


Locally Recurrent Head and Neck Squamous Cell Carcinoma

The reemergence of head and neck squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Functioning Lung Carcinoid Tumor

A lung neuroendocrine tumor that is associated with carcinoid syndrome.


Non-Functioning Lung Carcinoid Tumor

A lung neuroendocrine tumor that is not associated with carcinoid syndrome.


Recurrent Lung Neuroendocrine Neoplasm

The reemergence of a lung neuroendocrine neoplasm after a period of remission.


Locally Advanced Lung Neuroendocrine Neoplasm

A lung neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Complication of transplant

A problem arising from transplantation.


Advanced Lung Adenocarcinoma

Lung adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Locally Advanced Unresectable Primary Central Chondrosarcoma

A primary central chondrosarcoma that has spread from its original site of growth to nearby tissues and is not amenable to surgical resection.


IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY

An autosomal recessive common variable immunodeficiency caused by mutation(s) in the LRBA gene, encoding lipopolysaccharide-responsive and beige-like anchor protein. It is characterized by recurrent infections and the development of autoimmune disorders.


Metastatic Malignant Thoracic Neoplasm

A malignant thoracic neoplasm that has spread from its original site of growth to another anatomic site.


Advanced Malignant Thoracic Neoplasm

A malignant thoracic neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Prolonged grief disorder

A psychiatric disorder characterized by the personal experience of intense and prolonged yearning for, or preoccupation with the circumstances surrounding, a loss that leads to significant impairment in social or occupational functioning. Associated symptoms may include: identity disruption, disbelief, avoidance of reminders, difficulty moving on, emotional pain or numbness, feeling that life is meaningless, and loneliness.


Intrahepatic cholangiocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Bone Disease

Metastasis to bone that presents with subjective evidence of disease as perceived by the patient.


Refractory Ureter Urothelial Carcinoma

Ureter urothelial carcinoma that is resistant to treatment.


Refractory Urethral Urothelial Carcinoma

Urethral urothelial carcinoma that is resistant to treatment.


Refractory Renal Pelvis Urothelial Carcinoma

Renal pelvis urothelial carcinoma that is resistant to treatment.


Sezary syndrome recurrent

The reemergence of Sezary syndrome after a period of remission.


Sezary syndrome refractory

Sezary syndrome that is resistant to treatment.


Xerostomia caused by ionizing radiation

Dryness of the oral mucosa secondary to radiation therapy.


Metastatic Nasopharyngeal Nonkeratinizing Carcinoma

Nasopharyngeal non-keratinizing carcinoma that has spread from its original site of growth to another anatomic site.


Metastatic Lung Carcinoid Tumor

Lung neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Advanced Lung Carcinoid Tumor

Lung neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Lung Carcinoid Tumor

Lung neuroendocrine tumor that is not amenable to surgical resection.


Clonal Cytopenia of Undetermined Significance

Clinically meaningful cytopenia in one or more hematopoietic cell lineages. Clonal hematopoiesis is present with the variant allele frequency (VAF) equal or more that 2 percent. There is no other evidence of hematologic malignancy.


Advanced Salivary Gland Carcinoma

Salivary gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Medulloblastoma

Medulloblastoma that has spread from its original site of growth to another anatomic site.


Suprasellar germ cell tumor

A germ cell tumor that arises from the suprasellar region.


Microsatellite Stable Rectal Carcinoma

Rectal carcinoma characterized by the absence of microsatellite instability.


Microsatellite Stable Colon Carcinoma

Colon carcinoma characterized by the absence of microsatellite instability.


Refractory Low Grade Glioma

Low grade glioma that is resistant to treatment.


Recurrent Low Grade Glioma

The reemergence of low grade glioma after a period of remission.


Refractory Low Grade Astrocytoma

Low grade astrocytoma that is resistant to treatment.


Refractory WHO Grade 1 Glioma

WHO grade 1 glioma that is resistant to treatment.


Metastatic Microsatellite Stable Colon Carcinoma

Microsatellite stable colon carcinoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Digestive System Neuroendocrine Neoplasm

A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


PIK3CA related overgrowth spectrum

A group of rare disorders that are usually caused by somatic mutations in the PIK3CA gene, but may rarely be caused by de novo germline mutations. These disorders are typically characterized by sporadic overgrowth of parts of the body, intellectual disability, low muscle tone, and vascular malformations with congenital or early childhood onset. Representative examples include: fibroadipose hyperplasia, CLOVES syndrome, megalencephaly-capillary malformation syndrome, hemihyperplasia-multiple lipomatosis syndrome, hemimegalencephaly, and facial infiltrating lipomatosis.


Mucosal Melanoma of the Urinary System

A malignant melanocytic neoplasm that arises from a mucosal site of the urinary system.


round cell sarcoma with EWSR1-non-ETS fusion

A small cell sarcoma that is characterized by the presence of EWSR1 or FUS fusions involving partners unrelated to the ETS gene family.


Genitourinary syndrome of menopause

A spectrum of lower urogenital tract signs and symptoms that are associated with the decreased production of estrogen experienced during menopause.  Findings may include genital dryness, burning or irritation, dyspareunia, decreased libido, urinary urgency, dysuria and recurrent urinary tract infections.


Central Chondrosarcoma, Grade 2

An intermediate-grade chondrosarcoma arising in the medulla of bone.


Central Chondrosarcoma, Grade 3

A high-grade chondrosarcoma arising in the medulla of bone.


Penile Mucosal Melanoma

A melanoma that arises from the mucosa of the penis.


Nasopharyngeal Melanoma

A melanoma that arises from the mucosal surface of the nasopharynx.


Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma

The reemergence of an aggressive B-cell non-Hodgkin lymphoma after a period of remission.


Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

An aggressive B-cell non-Hodgkin lymphoma that is resistant to treatment.


Metastatic Low Grade Glioma

Low grade glioma that has spread from its primary site to another anatomic site.


Metastatic Low Grade Astrocytoma

Low grade astrocytoma that has spread from its primary site to another anatomic site.


Recurrent Fallopian Tube Mucinous Adenocarcinoma

The reemergence of fallopian tube mucinous adenocarcinoma after a period of remission.


Recurrent Ovarian Seromucinous Carcinoma

The reemergence of ovarian seromucinous carcinoma after a period of remission.


Refractory Fallopian Tube Mucinous Adenocarcinoma

Fallopian tube mucinous adenocarcinoma that is resistant to treatment.


Refractory Ovarian Seromucinous Carcinoma

Ovarian seromucinous carcinoma that is resistant to treatment.


Refractory Fallopian Tube Clear Cell Adenocarcinoma

Fallopian tube clear cell adenocarcinoma that is resistant to treatment.


Refractory Fallopian Tube Endometrioid Adenocarcinoma

Fallopian tube endometrioid adenocarcinoma that is resistant to treatment.


Refractory Fallopian Tube Transitional Cell Carcinoma

Fallopian tube transitional cell carcinoma that is resistant to treatment.


Refractory Fallopian Tube Undifferentiated Carcinoma

Fallopian tube undifferentiated carcinoma that is resistant to treatment.


Refractory Fallopian Tube High Grade Serous Adenocarcinoma

Fallopian tube high-grade serous adenocarcinoma that is resistant to treatment.


Refractory Ovarian High Grade Serous Adenocarcinoma

Ovarian high-grade serous adenocarcinoma that is resistant to treatment.


Refractory Low Grade Fallopian Tube Serous Adenocarcinoma

Low grade fallopian tube serous adenocarcinoma that is resistant to treatment.


Refractory Ovarian Low Grade Serous Adenocarcinoma

Ovarian low-grade serous adenocarcinoma that is resistant to treatment.


Refractory Ovarian Clear Cell Adenocarcinoma

Ovarian clear cell adenocarcinoma that is resistant to treatment.


Refractory Ovarian Mucinous Adenocarcinoma

Ovarian mucinous adenocarcinoma that is resistant to treatment.


Refractory Ovarian Transitional Cell Carcinoma

Ovarian transitional cell carcinoma that is resistant to treatment.


Refractory Ovarian Undifferentiated Carcinoma

Ovarian undifferentiated carcinoma that is resistant to treatment.


Refractory Primary Peritoneal Clear Cell Adenocarcinoma

Primary peritoneal clear cell adenocarcinoma that is resistant to treatment.


Refractory Primary Peritoneal Endometrioid Adenocarcinoma

Primary peritoneal endometrioid adenocarcinoma that is resistant to treatment.


Refractory Primary Peritoneal High Grade Serous Adenocarcinoma

Primary peritoneal high grade serous adenocarcinoma that is resistant to treatment.


Refractory Primary Peritoneal Low Grade Serous Adenocarcinoma

Primary peritoneal low grade serous adenocarcinoma that is resistant to treatment.


Refractory Primary Peritoneal Transitional Cell Carcinoma

Primary peritoneal transitional cell carcinoma that is resistant to treatment.


Refractory Primary Peritoneal Undifferentiated Carcinoma

Primary peritoneal undifferentiated carcinoma that is resistant to treatment.


Platinum-Refractory Malignant Female Reproductive System Neoplasm

A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing platinum therapy.


Platinum-Refractory Fallopian Tube Carcinoma

Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Platinum-Refractory Ovarian Carcinoma

Ovarian carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Platinum-Refractory Primary Peritoneal Carcinoma

Primary peritoneal carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Acute Respiratory Distress

An abrupt onset of signs or symptoms indicating difficulty breathing including alterations in breath sounds and rate, chest retractions and color changes.


B-Cell Lymphoproliferative Disorder

A non-neoplastic or neoplastic proliferation of B-lymphocytes.


Genetic Predisposition to Disease

The predisposition of an individual to develop a specific disease based on their heredity.


Reactogenicity

An expected set of reactions that may occur soon after injection of a vaccine. These expected adverse reactions are a physical manifestation of the inflammatory response to the vaccine.


Melanoma Metastatic in the Brain

A melanoma that has spread to the brain from its original site of growth, through the hematogenous route.


Refractory Lung Adenocarcinoma

Lung adenocarcinoma that is resistant to treatment.


Recurrent Diffuse Midline Glioma, H3 K27M-Mutant

The reemergence of diffuse midline glioma, H3 K27M mutant, after a period of remission.


Unresectable Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that is not amenable to surgical resection.


High Risk Breast Carcinoma

Breast carcinoma with clinicopathologic, cytogenetic, and molecular findings that define a breast carcinoma as high risk.


Metastatic Acral Lentiginous Melanoma

Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site.


Metastatic Platinum-Resistant Ovarian Carcinoma

A platinum-resistant ovarian carcinoma that has spread from its original site of growth to another anatomic site.


HER2-Low Breast Carcinoma

A breast adenocarcinoma defined by low expression of HER2 (IHC1+ or IHC2+; FISH negative).


Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Histologic transformation of an indolent B-cell non-Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


Multiple Metastases

More than one metastatic area.


Refractory Thyroid Gland Medullary Carcinoma

Thyroid gland medullary carcinoma that is resistant to treatment.


Low Grade Endometrial Endometrioid Adenocarcinoma

Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Clostridium difficile infection

A bacterial infection caused by Clostridium difficile (Clostridioides difficile), which is a spore-forming, toxin-producing Gram-positive anaerobic bacillus that is transmitted by the fecal-oral route. Infection may cause symptoms ranging from diarrhea to life-threatening inflammation of the colon, and risk factors include use of antibiotic medication, advanced age, and hospital or long-term care facility admission.


Muscle Invasive Bladder Urothelial Carcinoma

A bladder urothelial carcinoma invading into the bladder muscularis propria.


Localized Muscle Invasive Bladder Urothelial Carcinoma

A bladder urothelial carcinoma that has focally invaded into the bladder muscularis propria.


Urothelial Carcinoma, High Grade

Urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


hydatidiform mole, recurrent, 1

Any complete hydatidiform mole in which the cause of the disease is a mutation in the NLRP7 gene.


Cervical Squamous Cell Carcinoma, Not Otherwise Specified

Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Cerebrovascular Insufficiency

A condition resulting in inadequate blood flow through the blood vessels supplying the brain, due to intrinsic disease of the vasculature.


Unresectable Thymic Neuroendocrine Neoplasm

A thymic neuroendocrine neoplasm that is not amenable to surgical resection.


Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that has spread from its original site of growth to nearby tissues or lymph nodes.


Advanced Mucosal Melanoma

Mucosal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Atrophy of vagina

A condition characterized by the absence of squamous maturation in the vaginal epithelium. It is associated with decreased estrogen production.


Advanced Vaginal Adenocarcinoma

Vaginal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic HER2-Positive Breast Carcinoma

HER2-positive breast carcinoma that has spread from the original site of growth to another anatomic site.


Human Papillomavirus-Related Vaginal Adenocarcinoma

An adenocarcinoma that arises from the vagina and is caused by human papillomavirus infection.


Refractory Clear Cell Sarcoma of Soft Tissue

Clear cell sarcoma of soft tissue that is resistant to treatment.


Recurrent Clear Cell Sarcoma of Soft Tissue

The reemergence of clear cell sarcoma of soft tissue after a period of remission.


Advanced Vaginal Adenosquamous Carcinoma

Vaginal adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vaginal Squamous Cell Carcinoma

Vaginal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Early Stage Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that has not spread beyond the breast or axillary lymph nodes.


Locally Advanced HER2-Positive Breast Carcinoma

HER2-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Recurrent Distal Bile Duct Adenocarcinoma

The reemergence of distal bile duct adenocarcinoma after a period of remission.


Recurrent Glioblastoma, IDH-Wildtype

The reemergence of glioblastoma, IDH-wildtype after a period of remission.


Recurrent Metastatic Melanoma

The reemergence of metastatic melanoma after a period of remission.


Recurrent HER2-Positive Breast Carcinoma

The reemergence of HER2-positive breast carcinoma after a period of remission.


Penile squamous cell carcinoma metastatic

Squamous cell carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Metastatic Conjunctival Melanoma

Conjunctival melanoma that has spread from its original site of growth to another anatomic site.


Hypoperfusion

No component of the tumor exhibits perfusion equal to or greater than cerebellar gray matter, excluding encased or grossly visible intrinsic vasculature.


Disease remission

A decrease in or disappearance of signs and symptoms typically associated with a disease course.


Recurrent Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

The reemergence of diffuse large B-cell lymphoma associated with chronic inflammation after a period of remission.


Refractory Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Diffuse large B-cell lymphoma associated with chronic inflammation that is resistant to treatment.


Metastatic embryonal rhabdomyosarcoma

Embryonal rhabdomyosarcoma that has spread from its original site of growth to another anatomic site.


Metastatic Malignant Abdominal Neoplasm

A malignant neoplasm that arises from the abdomen and has spread from its original site of growth to another anatomic site.


Advanced Malignant Abdominal Neoplasm

A malignant neoplasm that arises from the abdomen and has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Fibrolamellar Carcinoma

Fibrolamellar carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Hematologic Neoplasm with Germline SAMD9 Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9 mutation.


Hematologic Neoplasm with Germline SAMD9L Mutation

Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9L mutation.


Locally Advanced Nasal Cavity Squamous Cell Carcinoma

Nasal cavity squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Paranasal Sinus Squamous Cell Carcinoma

Paranasal sinus squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


diffuse glioma, H3 G34 mutant

A histone mutated tumor that has material basis in mutations in codon 34 of the H3 histone family 3A protein.


Gastrointestinal toxicity

Toxicity that impairs or damages the gastrointestinal system.


Metastatic Hormone Receptor-Positive Breast Carcinoma

Hormone receptor-positive breast carcinoma that has spread from its original site of growth to another anatomic site.


Metastatic Triple-Negative Breast Inflammatory Carcinoma

Triple-negative breast inflammatory carcinoma that has spread from its original site of growth to another anatomic site.


Unresectable Ovarian High Grade Serous Adenocarcinoma

Ovarian high-grade serous adenocarcinoma that is not amenable to surgical resection.


Unresectable Ovarian Endometrioid Adenocarcinoma

Ovarian endometrioid adenocarcinoma that is not amenable to surgical resection.


Unresectable Fallopian Tube Endometrioid Adenocarcinoma

Fallopian tube endometrioid adenocarcinoma that is not amenable to surgical resection.


Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma

Primary peritoneal high-grade serous adenocarcinoma that is not amenable to surgical resection.


Unresectable Primary Peritoneal Endometrioid Adenocarcinoma

Primary peritoneal endometrioid adenocarcinoma that is not amenable to surgical resection.


Unresectable HER2-Positive Breast Carcinoma

HER2-positive breast carcinoma that is not amenable to surgical resection.


Chronic pulmonary aspergillosis

A spectrum of disorders associated with long-term Aspergillus infection of the lung that usually occur in immunocompetent individuals with underlying respiratory disorders, and may be characterized by pulmonary fibrosis or cavitation.


Metastatic Prostate Adenocarcinoma with Neuroendocrine Differentiation

Prostate adenocarcinoma with neuroendocrine differentiation that has spread from its original site of growth to another anatomic site.


Advanced Prostate Adenocarcinoma with Neuroendocrine Differentiation

Prostate adenocarcinoma with neuroendocrine differentiation that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma, after a period of remission.


Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma and is resistant to treatment.


Sarcopenia

A reduction in muscle mass and function that is associated with aging or disuse.


Pelvic Floor Disorders

A disorder affecting the muscles of the pelvic floor.


Unresectable HER2-Negative Breast Carcinoma

A HER2-negative breast adenocarcinoma that is not amenable to surgical resection.


Recurrent Childhood Osteosarcoma

The reemergence of childhood osteosarcoma after a period of remission.


Refractory Childhood Osteosarcoma

Childhood osteosarcoma that is resistant to treatment.


Refractory Childhood Rhabdomyosarcoma

Childhood rhabdomyosarcoma that is resistant to treatment.


Refractory Childhood Soft Tissue Sarcoma

Childhood soft tissue sarcoma that is resistant to treatment.


Locally Advanced Digestive System Neuroendocrine Tumor G1

Digestive system neuroendocrine tumor G1 that has spread from its original site of growth to nearby tissues or lymph nodes.


Corneal Endothelial Cell Loss

A decrease in corneal endothelial cell density.


Posterior capsule opacification

Remnant lens epithelial cell proliferation and migration to the posterior capsule.


Tooth Loss

One or more teeth lost/dislodged from the mouth.


Locally Advanced Unresectable HER2-Negative Breast Carcinoma

A HER2-negative breast adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

Hormone receptor-positive breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Locally Advanced Unresectable Triple-Negative Breast Carcinoma

Triple-negative breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


B-Cell Malignant Neoplasm

A clonal lymphoproliferative disorder composed of neoplastic B-cells. It includes B-cell non-Hodgkin lymphomas, B-cell leukemias, and plasma cell myeloma.


Refractory Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma that is resistant to treatment.


Resectable Breast Carcinoma

Breast carcinoma that is amenable to surgical resection.


Refractory Adrenal Cortical Carcinoma

Adrenal cortical carcinoma that is resistant to treatment.


Refractory Wilms Tumor

Wilms tumor that is resistant to treatment.


Locally Advanced Thyroid Gland Anaplastic Carcinoma

Thyroid gland anaplastic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Refractory Neoplastic Post-Transplant Lymphoproliferative Disorder

Neoplastic post-transplant lymphoproliferative disorder that is resistant to treatment.


Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder

The reemergence of neoplastic post-transplant lymphoproliferative disorder after a period of remission.


Advanced Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread from its original site of growth to another anatomic site.


Locally Advanced Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Unresectable Uterine Corpus Leiomyosarcoma

Uterine corpus leiomyosarcoma that is not amenable to surgical resection.


Asymptomatic human immunodeficiency virus infection

An infection caused by human immunodeficiency virus (HIV) that is asymptomatic at the time of testing.


Lung Injury

Damage to the lung from traumatic or pathologic processes.


Refractory Sclerodermatous Graft Versus Host Disease

Sclerodermatous Graft Versus Host Disease that is resistant to treatment.


Estrogen Receptor-Positive Breast Carcinoma

Breast adenocarcinoma that is positive for estrogen receptors.


Recurrent High Grade B-Cell Lymphoma, Not Otherwise Specified

The reemergence of high-grade B-cell lymphoma, not otherwise specified, after a period of remission.


Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified

High-grade B-cell lymphoma, not otherwise specified, that is resistant to treatment.


Recurrent ALK-Positive Large B-Cell Lymphoma

The reemergence of ALK-positive large B-cell lymphoma after a period of remission.


Refractory ALK-Positive Large B-Cell Lymphoma

ALK-positive large B-cell lymphoma that is resistant to treatment.


Immune-mediated colitis

Colitis caused by an immune reaction to an antigen, including a therapeutically administered agent.


Smokeless Tobacco Exposure

Environmental, occupational, or consumer-based exposure to any smokeless tobacco product.


Low Risk Myelodysplastic Syndrome

Myelodysplastic syndrome with a total score of more than 1.5 to 3, according to the revised International Prognostic Scoring System (IPSS-R).


Locally Recurrent Lung Non-Small Cell Carcinoma

The reemergence of lung non-small cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Recurrent Non-Muscle Invasive Bladder Carcinoma

The reemergence of non-muscle invasive bladder carcinoma after a period of remission.


Recurrent MGMT-Methylated Glioblastoma

The reemergence of MGMT-methylated glioblastoma after a period of remission.


Recurrent basal cell carcinoma

The reemergence of basal cell carcinoma after a period of remission.


Unresectable Pancreatic Neuroendocrine Tumor

Pancreatic neuroendocrine tumor that is not amenable to surgical resection.


Renal Cell Carcinoma, Not Otherwise Specified

A renal cell carcinoma that cannot be classified into one of the established subtypes of renal cell carcinoma.


Acute Cerebrovascular Accidents

The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system.


Intracardiac Thrombus Related to COVID-19

Thrombus formation in the chambers of the heart in a patient with probable or confirmed acute COVID-19.


Acute Heart Failure Related to COVID-19

New or worsening signs of heart failure in a patient with probable or confirmed acute COVID-19. This can be the first presentation or it can reflect an acute decompensation in a patient with history of chronic heart failure.


Acute pulmonary edema

Rapid or severe onset or rapid progression of pulmonary edema causing significant hypoxemia or the need for supplemental oxygen.


squamous cell carcinoma of urinary tract

A rare squamous cell carcinoma that arises from the urinary tract. Almost all cases have been reported in the bladder. Causes include urinary stasis, recurrent chronic inflammation, and smoking. In regions where schistosomiasis is endemic, it is the major etiologic factor of bladder squamous cell carcinoma.


Intermediate Risk Prostate Carcinoma

Prostate carcinoma with clinicopathologic, cytogenetic, and molecular findings that define a prostate carcinoma as intermediate risk.


Recurrent Extrapulmonary Neuroendocrine Carcinoma

The reemergence of extrapulmonary neuroendocrine carcinoma after a period of remission.


Unresectable Extrapulmonary Neuroendocrine Carcinoma

Extrapulmonary neuroendocrine carcinoma that is not amenable to surgical resection.


Metastatic Extrapulmonary Neuroendocrine Carcinoma

Extrapulmonary neuroendocrine carcinoma that has spread to another anatomic site.


Advanced Extrapulmonary Neuroendocrine Carcinoma

Extrapulmonary neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Alloimmune platelet transfusion refractoriness

An indication that platelet counts were not increased following one or more transfusions.


Reperfusion Injury

Tissue damage caused when blood supply returns to tissue after a period of ischemia or lack of oxygen. The restoration of circulation results in inflammation and oxidative damage.


Recurrent Acute Myeloid Leukemia with KMT2A Rearrangement

The reemergence of acute myeloid leukemia with KMT2A rearrangement after a period of remission.


Rectal Gastrointestinal Stromal Tumor

Gastrointestinal stromal tumor that arises from the rectum.


Recurrent Juvenile Myelomonocytic Leukemia

The reemergence of juvenile myelomonocytic leukemia after a period of remission.


Recurrent Myeloid Sarcoma

The reemergence of myeloid sarcoma after a period of remission.


Chronic viral hepatitis B with hepatitis D

Evidence of chronic viral hepatitis B with delta-agent.


Chronic viral hepatitis B without delta-agent

Evidence of chronic viral hepatitis B without delta-agent.


Type 1 diabetes mellitus with established diabetic nephropathy

Evidence of type 1 diabetes mellitus with diabetic nephropathy.


Drug-induced obesity

Evidence of drug-induced obesity.


alcohol dependence in remission

Evidence of alcohol dependence, in remission.


Cocaine abuse, in remission

Evidence of cocaine abuse, in remission.


Cocaine dependence in remission

Evidence of cocaine dependence, in remission.


Drug-Induced Movement Disorder, Unspecified

Evidence of drug-induced movement disorder.


Pulmonary hypertension due to left heart disease

Evidence of pulmonary hypertension due to left heart disease.


Nontraumatic Intracerebral Hemorrhage, Multiple Localized

Evidence of nontraumatic intracerebral hemorrhage, multiple localized.


Acute exacerbation of chronic obstructive pulmonary disease

Evidence of chronic obstructive pulmonary disease with acute exacerbation.


Uncomplicated mild persistent asthma

Evidence of mild persistent asthma, uncomplicated.


Acute exacerbation of bronchiectasis

Evidence of bronchiectasis with acute exacerbation.


Moderate hypoxic ischemic encephalopathy

Evidence of moderate hypoxic ischemic encephalopathy.


Severe hypoxic ischemic encephalopathy

Evidence of severe hypoxic ischemic encephalopathy.


post-traumatic seizures

Evidence of post traumatic seizures.


High Grade Osteosarcoma

An aggressive osteosarcoma with high-grade morphological features. This category includes high-grade surface osteosarcoma and conventional osteosarcoma.


Disruptive mood dysregulation disorder

A condition in which children or adolescents experience irritability, anger, and intense temper outbursts. The episodes may be frequent and may eventually impact functioning at school, at home or with peers.


Dissection, Thoracic Aorta

A tear within the wall of the thoracic aorta.


End stage cardiac failure

The terminal phase of heart failure in patients. The disease course may have progressed despite intervention and may be characterized by dyspnea, fatigue, and weakness.


Hypertensive Urgency

Hypertensive crisis without end-organ damage.


Manic Episode

A sustained period of enhanced excitability and excessive energy, often in the presence of euphoria.


Premenstrual Dysphoric Disorder

A more severe form of premenstrual syndrome (PMS) with more extreme mood and physical symptoms. As with PMS, symptoms begin prior to an individual's menstrual cycle and typically taper off as menstruation begins.


Rheumatic mitral stenosis

Mitral valve stenosis secondary to rheumatic fever.


Schizoaffective disorder, bipolar type

Schizoaffective disorder with episodes of mania and depression.


Schizoaffective disorder, depressive type

Schizoaffective disorder with episodes of depression only.


Neurological ventriculitis

Inflammation of a cerebral ventricle.


Gross Extranodal Extension

An indication that the lymph node metastases of a malignant neoplasm have invaded adjacent organs.


Recurrent High Grade Endometrioid Adenocarcinoma

The reemergence of high-grade endometrioid adenocarcinoma after a period of remission.


Low Grade Ovarian Endometrioid Adenocarcinoma

Ovarian endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


High Grade Ovarian Endometrioid Adenocarcinoma

Ovarian endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


Recurrent Fallopian Tube Carcinosarcoma

The reemergence of fallopian tube carcinosarcoma after a period of remission.


Recurrent Primary Peritoneal Carcinosarcoma

The reemergence of primary peritoneal carcinosarcoma after a period of remission.


Fluid Overload

A finding indicating the presence of fluid accumulation in tissues and body cavities.


Suppression of adrenal gland

Inadequate production of cortisol due to negative feedback on the hypothalamic-pituitary-adrenal axis that is caused by exposure to exogenous glucocorticoids or endogenous hypercortisolism.


Unresectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma of the head and neck that is not amenable to surgical resection.


Hereditary Transthyretin Amyloidosis with Polyneuropathy

A rare, progressive, autosomally dominant inherited peripheral neuropathy caused by mutations in the TTR gene encoding transthyretin (prealbumin).  It is characterized by deposition of amyloid fibrils in the peripheral nervous system.


Graft Rejection

Rejection of transplanted tissue secondary to an immune response from the recipient.


Metastatic Midgut Neuroendocrine Tumor G1

A midgut neuroendocrine tumor G1 that has spread from its original site of growth to another anatomic site.


Metastatic Midgut Neuroendocrine Tumor G2

A midgut neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


Intrahepatic cholangiocarcinoma that has metastasized to a limited number of sites.


Classic Follicular Lymphoma

A term that refers to follicular lymphoma grade 1, 2, and 3A.


Follicular Lymphoma with Unusual Cytological Features

An uncommon morphologic variant of follicular lymphoma characterized by the presence of predominantly medium-sized neoplastic lymphocytes with blastoid features or large neoplastic lymphocytes with cleaved nuclei.


Recurrent WHO Grade 4 Glioma

The reemergence of WHO grade 4 glioma after a period of remission.


Steroid Resistant Chronic Graft Versus Host Disease

Chronic graft versus host disease that is resistant to treatment with steroids.


Unresectable Penile Squamous Cell Carcinoma

Penile squamous cell carcinoma that is not amenable to surgical resection.


Localized Prostate Adenocarcinoma

An adenocarcinoma that arises from the prostate and has not spread to other anatomic sites.


Locally Advanced Extraskeletal Myxoid Chondrosarcoma

Extraskeletal myxoid chondrosarcoma that has spread to nearby tissues or lymph nodes.


Non-Clear Cell Renal Cell Carcinoma

A group of renal cell carcinomas characterized by the absence of lipid-containing clear adenocarcinoma cells. This category includes the following morphological subtypes: papillary renal cell carcinoma; sarcomatoid renal cell carcinoma; chromophobe renal cell carcinoma; tubulocystic renal cell carcinoma; and eosinophilic solid and cystic renal cell carcinoma.


Neuroendocrine Tumor G1

A well-differentiated, low-grade epithelial neoplasm with neuroendocrine differentiation. It arises from multiple sites, including the digestive system, lung, and head and neck.


Neuroendocrine Tumor G3

A well-differentiated, high-grade epithelial neoplasm with neuroendocrine differentiation. It usually arises from the digestive system.


Histiocytic Disorder

A group of non-neoplastic and neoplastic disorders characterized by the proliferation of histiocytes. This category includes hemophagocytic lymphohistiocytosis and histiocytic and dendritic cell neoplasms.


Myeloproliferative Chronic Myelomonocytic Leukemia

Chronic myelomonocytic leukemia characterized by the presence of a markedly elevated white blood cell count in the peripheral blood.


Metastatic Olfactory Neuroblastoma

Olfactory neuroblastoma that has spread from its original site of growth to other anatomic sites.


Locally Advanced Olfactory Neuroblastoma

Olfactory neuroblastoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Refractory Juvenile Myelomonocytic Leukemia

Juvenile myelomonocytic leukemia that is resistant to treatment.


Recurrent Acute Myeloid Leukemia due to Lineage Switch from B Acute Lymphoblastic Leukemia, KMT2A-Rearranged

A finding of reemergence of acute myeloid leukemia due to lineage switch from B acute lymphoblastic leukemia, KMT2A-rearranged.


Refractory Acute Myeloid Leukemia due to Lineage Switch from B Acute Lymphoblastic Leukemia, KMT2A-Rearranged

A finding of acute myeloid leukemia due to lineage switch from B acute lymphoblastic leukemia, KMT2A-rearranged, that is resistant to treatment.


Recurrent Acute Myeloid Leukemia due to Lineage Switch from Acute Leukemia of Ambiguous Lineage

A finding of reemergence of acute myeloid leukemia due to lineage switch from acute leukemia of ambiguous lineage.


Refractory Acute Myeloid Leukemia due to Lineage Switch from Acute Leukemia of Ambiguous Lineage

A finding of acute myeloid leukemia due to lineage switch from acute leukemia of ambiguous lineage, that is resistant to treatment.


Recurrent Acute Myeloid Leukemia due to Lineage Switch from Mixed Phenotype Acute Leukemia

A finding of reemergence of acute myeloid leukemia due to lineage switch from mixed phenotype acute leukemia.


Refractory Acute Myeloid Leukemia due to Lineage Switch from Mixed Phenotype Acute Leukemia

A finding of acute myeloid leukemia due to lineage switch from mixed phenotype acute leukemia, that is resistant to treatment.


Gastroesophageal Junction Carcinoma

A carcinoma that arises from the gastroesophageal junction. The vast majority of cases are adenocarcinomas. Rare cases are neuroendocrine carcinomas.


FGFR3 Overexpression Positive

An indication that overexpression of FGFR3 has been detected in a sample.


Melanosis

A benign congenital or acquired lesion that arises from mucosal sites and is characterized by melanin pigment deposition in the basilar keratinocytes. It may be associated with a slight proliferation of junctional melanocytes. It presents as a single or multiple pigmented macules or patches in the external genitalia, anorectal region, distal urinary tract, and oral cavity.


Early Stage Hepatocellular Carcinoma

A stage term referring to hepatocellular carcinoma that presents as a single tumor with the largest diameter measuring 2 cm or less. The liver function is well-preserved and there is no vascular invasion or metastasis. (Barcelona Liver Cancer Classification).


Physical addiction

The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered.


Non-Neoplastic Hematologic and Lymphocytic Disorder

A non-neoplastic disorder that arises from hematopoietic and lymphoid cells. It is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Colles' Fracture

An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment.


Acquired Hypogammaglobulinemia

A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.


Complication of transplanted organ, NOS

A disease or disorder that is associated with a transplanted organ.


Corneal Abrasions

Injury to the epithelium of the cornea.


Embolism

The blockage of a blood vessel lumen by air or solid material such as blood clot or other tissues (e.g., adipose tissue, cancer cells) that have migrated from another anatomic site.


Stress Fractures

A small, traumatic break or severe bruising of a bone caused by repetitive application of force.


Hemorrhage

The flow of blood from a ruptured blood vessel.


Fractured mandible

A partial or complete breakage of the mandible.


Peritoneal Diseases

A non-neoplastic or neoplastic disorder that affects the peritoneum.  Representative examples of non-neoplastic disorders include peritonitis and panniculitis.  Representative examples of neoplastic disorders include adenomatoid tumor, primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma.


Acute gastritis

Acute inflammation of the stomach.


Fracture of clavicle

A traumatic or pathologic injury to the clavicle in which the continuity of the clavicle is broken.


Fractured forearm bones

Bone fracture in the radius, ulna, or wrist.


Complications of transplanted heart

A disease or disorder that is associated with a transplanted heart.


Complication of transplanted lung

A disease or disorder that is associated with a transplanted lung.


Cicatrix, Hypertrophic

A permanent mark on the skin caused by deposits of excessive amounts of collagen during wound healing. It is elevated and does not extend beyond the original boundaries of the wound; the elevation may stabilize or regress spontaneously.


Aneurysm, Ruptured

An aneurysm that has burst, resulting in hemorrhage into adjacent tissues.


Blood Clot

An aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation.


Fracture of acetabulum

A traumatic break in the portion of the pelvic bone that forms the hip socket.


Fractured hand bones

A traumatic break in one or more of the bones in the hand.


Systemic lupus erythematosus rash

A rash associated with systemic lupus erythematosus.


Fractured elbow

A partial or complete breakage of the elbow.


Fractured knee

A partial or complete breakage of the knee.


Adult L1 Acute Lymphoblastic Leukemia

L1 acute lymphoblastic leukemia that occurs during adulthood.


Secondary Myelodysplastic Syndrome

A myelodysplastic syndrome resulting from chemotherapy or radiation therapy for cancer or exposure to certain chemicals.


Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

A small round cell tumor with or without neural differentiation that has spread from its original site of growth to another anatomic site.


Recurrent Primitive Neuroectodermal Tumor

The reemergence of a primitive neuroectodermal tumor of the central or the peripheral nervous system after a period of remission.


Hormonal Change

A finding indicating a deficiency or excess of one or more hormones.


Cholangiocarcinoma non-resectable

Cholangiocarcinoma that is not amenable to surgical resection.


Cholangiocarcinoma recurrent

The reemergence of cholangiocarcinoma after a period of remission.


Cholangiocarcinoma resectable

Cholangiocarcinoma that is amenable to surgical resection.


Unresectable Hepatocellular Carcinoma

A hepatocellular carcinoma that is not amenable to surgical resection.


Immune System and Related Disorders

A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


Recurrent Hematologic Malignancy

The reemergence of a hematologic malignancy after a period of remission.


Unresectable Malignant Neoplasm

A malignant neoplasm which is not amenable to surgical resection.


Childhood Clear Cell Sarcoma of Soft Parts

A clear cell sarcoma of soft tissue occurring in children.


Childhood Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor occurring in children.


Adult Desmoplastic Small Round Cell Tumor

A desmoplastic small round cell tumor occurring in adults.


Metastatic Carcinoma in the Adrenal Cortex

A carcinoma that has spread to the adrenal cortex from an adjacent or distal anatomic site.


Carcinomatosis of peritoneal cavity

A condition in which a carcinoma has spread extensively throughout the peritoneum.


Metastatic Carcinoma in the Lung

The spread of a carcinoma to the lung. This may be from a primary lung carcinoma, or from a carcinoma at a distant anatomic site.


Primary Cutaneous Mucinous Carcinoma

A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology).


Head and Neck Disorder

A non-neoplastic or neoplastic disorder that affects the anatomic structures of the head and neck region.  This category includes inflammatory disorders, benign neoplasms, precancerous conditions, and malignant neoplasms.


Transplant-Related Carcinoma

A carcinoma that arises in a patient with a history of organ transplantation.


A hematologic malignancy that arises in a patient with a history of organ transplantation.


HPV-related carcinoma

A carcinoma associated with the presence of human papillomavirus infection.


Human Papillomavirus-Related Cervical Carcinoma

A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

A cervical squamous cell carcinoma associated with human papillomavirus infection.


Human Papillomavirus-Related Cervical Adenocarcinoma

A cervical adenocarcinoma associated with the presence of human papillomavirus infection.


Human Papillomavirus-Related Vulvar Squamous Cell Carcinoma

A squamous cell carcinoma that arises from the vulva and is caused by human papillomavirus infection.


Human Papillomavirus-Related Anal Squamous Cell Carcinoma

An anal squamous cell carcinoma related to infection with sexually transmittable human papillomavirus.


An adenocarcinoma associated with the presence of human papillomavirus infection.


EBV-Related Carcinoma

Carcinoma that develops in individuals infected with Epstein-Barr virus (EBV), and in which there is a well-documented association between the neoplastic process and EBV.


Lymphoma, EBV-associated

Lymphoma that is caused by Epstein-Barr virus infection.


EBV-Related Hodgkin Lymphoma

Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


EBV-Related Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


Post transplant Epstein-Barr virus associated lymphoproliferative disorder

A lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


Myelofibrosis due to another disorder

Myelofibrosis that develops in patients with a history of hematologic malignancies or toxic injury to the bone marrow.


Previously Treated Myelodysplastic Syndrome

A myelodysplastic syndrome for which a patient has received treatment in the past.


Human Papillomavirus-Related Malignant Neoplasm

A malignant neoplasm associated with the presence of human papillomavirus infection.


Skin Radiation-Related Angiosarcoma

A malignant vascular neoplasm arising from an area of skin exposed to radiation therapy.


A myelodysplastic syndrome resulting from chemotherapy or radiation therapy for cancer.