name: Steroid Resistant Acute Graft Versus Host Disease

description: Acute graft versus host disease that is resistant to treatment with steroids.


name: Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Fallopian Tube Metaplastic Papillary Tumor

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


name: Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Malignant Solid Neoplasm

description: A malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include carcinomas and sarcomas. Hematopoietic and lymphoid tissue malignancies are not considered solid neoplasms.


Recurrent Fallopian Tube Carcinoma

description: The reemergence of fallopian tube carcinoma after a period of remission.


Grade 1 Ascites, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 CNS Necrosis and Cystic Progression, CTCAE


Premalignant Neoplasm

description: A neoplasm that is composed of dysplastic cells and there is no morphologic evidence of infiltration of the surrounding tissues.


name: Non-Neoplastic Disorder by Special Category


ROSE Cluster 1

description: Gene expression cluster 1 as determined by Recognition of Outliers by Sampling Ends (ROSE) in high-risk B-precursor acute lymphoblastic leukemia.


Recurrent Nervous System Neoplasm

description: The reemergence of a nervous system neoplasm after a period of remission.


Astler-Coller C1 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: Refractory T-Cell Large Granular Lymphocyte Leukemia

description: T-cell large granular lymphocyte leukemia that is resistant to treatment.


Hereditary Malignant Neoplasm

description: Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Occlusion of inferior vena cava

description: Blockage of the lumen of the inferior vena cava.


name: Lugano Classification Advanced Stage Adult Lymphoma AJCC v8

description: Advanced stage adult lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Radiation Recall Reaction (Dermatologic), CTCAE

description: Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated


Monogenic Hyperinsulinism

description: A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


name: Genitourinary Stricture and Stenosis Including Anastomotic Stricture and Stenosis, CTCAE


name: Grade 4 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Infections and Infestations - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


name: Grade 2 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ectopic ureter

description: A congenital anomaly in which the ureteral orifice drains into an abnormal location.


name: Grade 1 Jejunum Intra-Operative Injury, CTCAE


name: Grade 5 Phrenic Nerve Dysfunction, CTCAE


Advanced Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

description: A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


name: Extended Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that eventually involves more than four separate joints.


Grade 3 Arterial Thromboembolism, CTCAE

description: Urgent intervention indicated


name: Staphylococcal arthritis and polyarthritis


name: Intellectual Disability, Autosomal Dominant 4

description: An autosomal dominant condition caused by mutation(s) in the CHAMP1 gene, encoding chromosome alignment-maintaining phosphoprotein 1. It is characterized by moderate to severe intellectual disability with poor speech acquisition. Variable dysmorphic features may be present as well.


name: Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


name: Grade 2 Prolonged Intubation After Pulmonary Resection, CTCAE


Neoplasm of lacrimal drainage system

description: A benign or malignant neoplasm that affects the lacrimal drainage system.


name: Grade 5 Stoma GI Stricture or Stenosis, CTCAE


name: Grade 5 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Ovarian Infection

description: An infectious process affecting the ovary.


name: Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Invasive Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Grade 3 Colonic Obstruction, CTCAE

description: Hospitalization indicated; invasive intervention indicated


Occupational Malignant Neoplasm

description: Malignant neoplasm secondary to occupational exposure to carcinogens.


Grade 1 Arterial Injury, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Neonatal Diarrhea, AE

description: An adverse event in a newborn characterized by watery bowel movements.


name: Grade 2 Ileum Intra-Operative Injury, CTCAE


name: Grade 2 Neonatal Gastrointestinal Bleeding, AE

description: A gastrointestinal bleeding adverse event in a newborn characterized by moderate bleeding; minor change in care or monitoring required.


name: Grade 5 Sinusoidal Obstruction Syndrome, CTCAE

description: Death


Neuroendocrine cervical carcinoma

description: A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Grade 1 Eye Pain, CTCAE

description: Mild pain


Acute Stroke Related to COVID-19

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system in a patient with probable or confirmed acute COVID-19.


name: Verrucous carcinoma of the oral cavity stage IV


name: Grade 5 Rectal Varices Hemorrhage, CTCAE


name: Biliary Tree Stricture or Stenosis, CTCAE


name: Grade 3 Testes Stricture or Stenosis, CTCAE


Supratentorial Meningioma

description: A meningioma that affects the supratentorial brain.


name: Grade 5 Gastrointestinal Stoma Leak, CTCAE


name: Grade 2 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Glassy cell carcinoma

description: A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm.


name: Grade 4 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Stage IIC Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Pruritus, CTCAE

description: A disorder characterized by an intense itching sensation.


Grade 4 Vagus Nerve Disorder, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Glossopharyngeal Nerve Disorder, CTCAE


Low grade appendiceal mucinous neoplasm

description: A well differentiated mucinous neoplasm that arises from the appendix.  It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei.


Distress

description: A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures.


Genitourinary System Neoplasm

description: A benign or malignant neoplasm that affects the genitourinary system.


name: Gastrointestinal Stoma Hemorrhage, CTCAE


name: Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Patient Allergic to Contrast Media

description: Patient identified to be at risk for an allergic reaction to contrast media.


name: Grade 2 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Urethral Cancer by AJCC v8 Stage

description: A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Diffuse Non-Pontine Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system, other than the pons.


Grade 1 Movements Involuntary, CTCAE

description: Mild symptoms


Grade 5 Biliary Tract Infection, CTCAE

description: Death


Grade 2 Alopecia, CTCAE

description: Hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact


name: Cerebral Venous Thrombosis Related to COVID-19


Grade 3 Portal Vein Thrombosis, CTCAE

description: Medical intervention indicated


Ejection Fraction Decreased, CTCAE

description: The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction.


name: Skin and Subcutaneous Tissue Disorders, CTCAE


Perihepatic abscess

description: An abscess that is located in the anatomical space surrounding the liver, but which is outside of the liver capsule itself.


Panniculitis Ossificans

description: A condition characterized by subcutaneous fat necrosis with heterotopic calcification. It often occurs as a result of injury to the area.


name: Recurrent Fallopian Tube Clear Cell Adenocarcinoma

description: The reemergence of fallopian tube clear cell adenocarcinoma after a period of remission.


Astler-Coller B3 Rectal Carcinoma

description: Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


name: Vaginal Mucinous Adenocarcinoma, Intestinal-Type

description: A vaginal mucinous adenocarcinoma that resembles a large intestinal adenocarcinoma.


Fallopian Tube Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures).


Meningeal Leukemia

description: Infiltration of the meninges by an acute or chronic leukemia.


Locally Advanced Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 3 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Hepatic Necrosis, CTCAE

description: Life-threatening consequences; urgent invasive intervention indicated


Acquired hydrocephalus

description: Hydrocephalus that results from head trauma, brain tumors, intracranial hemorrhage, or meningitis.


name: Recurrent Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in childhood after a period of remission.


Grade 4 Thromboembolic Event, CTCAE

description: Life-threatening consequences with hemodynamic or neurologic instability


name: Grade 2 Activated Partial Thromboplastin Time Prolonged, CTCAE

description: >1.5-2.5 x ULN


name: Aspartate Aminotransferase Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen.


name: Grade 4 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Epstein-Barr Virus Infection Reactivation, CTCAE

description: Death


Grade 2 Nail Loss, CTCAE

description: Symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL


name: Refractory Adult Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that occurs in adulthood and does not respond to treatment.


name: Grade 4 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pigmented Actinic Keratosis

description: Actinic keratosis characterized by the presence of increased melanin pigmentation in the basal keratinocytes.


name: Metastatic Childhood Retinoblastoma by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage II Extragonadal Non-Seminomatous Germ Cell Tumor


Myxoid pleomorphic liposarcoma

description: An exceptionally rare, aggressive adipocytic neoplasm, typically occurring in children and adolescents. Myxoid pleomorphic liposarcoma shows mixed histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and lacks the gene fusions and amplifications of myxoid liposarcoma, atypical lipomatous tumor, and dedifferentiated liposarcoma. (WHO 2020)


name: Grade 2 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: T Acute Lymphoblastic Leukemia with SPI1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of SPI1 gene rearrangement. It has a poor prognosis.


Grade 3 Seroma, CTCAE

description: Symptomatic, elective invasive intervention indicated


name: Pediatric Non-Congenital Ventricular Tachycardia

description: A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin that was not present at birth in an individual under age 21. The QRS complexes are wide and have an abnormal morphology.


Grade 1 Edema Trunk, CTCAE

description: Swelling or obscuration of anatomic architecture on close inspection


name: Grade 3 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Esophageal carcinoma recurrent

description: An esophageal carcinoma which has reappeared after a period of remission or after presumed treatment.


Stage II Fallopian Tube Cancer

description: Stage II includes: (T2, N0, M0); IIA: (T2a, N0, M0); IIB (T2b, N0, M0); IIC (T2c, N0, M0).  T2: Tumor involves one or both fallopian tubes with pelvic extension.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  T2b: Extension to other pelvic structures.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Hyperviscosity

description: An increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity.


Stage IB Cervical Cancer AJCC v6 and v7

description: Stage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Neonatal Hypertension, AE

description: A hypertensive adverse event in a newborn which results in death.


Grade 4 Suicide Attempt, CTCAE

description: Suicide attempt with intent to die which requires hospitalization


Metastatic High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to another anatomic site.


name: benign granular cell tumor of gallbladder

description: A granular cell tumor that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Aplastic Anemia due to Hepatitis

description: Bone marrow failure defined as pancytopenia, secondary to hepatitis.


Grade 2 Tracheal Mucositis, CTCAE

description: Moderate symptoms; medical intervention indicated; limiting instrumental ADL


Reticulosarcoma of spleen

description: An antiquated term that refers to a non-Hodgkin lymphoma composed of diffuse infiltrates of large, often anaplastic lymphocytes affecting the spleen.


Grade 2 Chylothorax, CTCAE

description: Symptomatic; medical intervention indicated (e.g., fat-restricted diet); thoracentesis or tube drainage indicated


name: immune effector cell-associated neurotoxicity syndrome, grade 4

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0 or if the ICE scale cannot be performed (for adults and children over 12), or if the Cornell Assessment of Pediatric Delirium (CAPD) scale cannot be performed (for children 12 and under), the inability of the affected individual to be arousable without vigorous or repetitive tactile stimuli, life-threatening prolonged (greater than 5 minutes) seizures, or repetitive clinical or electroencephalographically-detected seizures without ever returning to baseline, deep focal motor weakness, diffuse cerebral edema evident on neuroimaging, decerebrate or decorticate posturing, cranial nerve VI palsy, papilledema or Cushing's triad (bradycardia, hypertension, respiratory depression).


Cervical Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the cervix.


name: Grade 3 Parotid Gland Intra-Operative Injury, CTCAE


name: Grade 4 Investigations - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Ancylostomiasis due to Ancylostoma braziliense (disorder)

description: Infection by Ancylostoma braziliense.


name: Grade 3 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Otitis External Ear Non Infectious, CTCAE


name: Grade 2 Lymphocyte Count Decreased, CTCAE

description: <800-500/mm3; <0.8-0.5 x 10e9/L


Pharyngitis, CTCAE

description: A disorder characterized by inflammation of the throat.


name: Grade 4 Intraoperative Renal Injury, CTCAE


Grade 3 Esophageal Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Grade 2 Hemorrhoidal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Metastatic Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread to another anatomic site.


Refractory Cutaneous Melanoma

description: Melanoma of the skin that is resistant to treatment.


Grade 2 Vomiting, CTCAE

description: Outpatient IV hydration; medical intervention indicated


Breast Schwannoma

description: A schwannoma that arises from the breast.


Decreased Concomitant Drug Half Life

description: Decreased period of time required for the concentration or amount of a concomitant drug in the body to be reduced to exactly one-half of a given concentration or amount.


Grade 2 Edema Face, CTCAE

description: Moderate localized facial edema; limiting instrumental ADL


Structural Heart Abnormality

description: An anatomic deformity of the heart, ventricles or great vessels.


Retinal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the retina.


Grade 1 Tinnitus, CTCAE

description: Mild symptoms; intervention not indicated


Foreign body granuloma of muscle

description: An inflammatory lesion in the muscle comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material .


name: Refractory Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is resistant to treatment.


Recurrent EBV-Related Lymphoma

description: The reemergence of EBV-related lymphoma after a period of remission.


name: Grade 4 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Paratesticular Adenomatoid Tumor

description: An adenomatoid tumor arising from the paratesticular structures. It is the most common tumor of the paratesticular region. The tail of the epididymis is the most common site of involvement.


Perforation Bile Duct, CTCAE

description: A disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct.


name: Grade 3 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Belching, CTCAE

description: To expel gas noisily from the mouth.


Pancreatic adenocarcinoma metastatic

description: An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites.


description: A lymphoproliferative disorder that develops in an individual with HIV infection.


name: Glioneuronal Tumor with Neuropil-Like Islands

description: A rare, WHO grade II or III infiltrating astrocytoma characterized by the presence of sharply demarcated foci, composed of a neuropil-like matrix.


Stage IIIC Esophageal Cancer AJCC v7

description: Stage IIIC includes: For squamous cell carcinoma: (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 5 Respiratory Failure, CTCAE

description: Death


name: Grade 4 Cranial Nerve VII Neuropathy, CTCAE


Grade 3 Hyperphosphatemia, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Grade 5 Jejunal Obstruction, CTCAE

description: Death


name: Extrahepatic Bile Duct Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts.


Grade 3 Febrile Neutropenia, CTCAE

description: ANC <1000/mm3 with a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour


Diabetic foetopathy

description: A constellation of features seen in the hyperinsulinemic fetus of a diabetic mother that include macrosomia, postnatal hypoglycemia and polycythemia.


Grade 4 Pregnancy Loss, CTCAE

description: Fetal loss at any gestational age


name: Grade 5 Gastrointestinal Disorders - Other, Specify, CTCAE

description: Death


Grade 2 Constipation, CTCAE

description: Persistent symptoms with regular use of laxatives or enemas; limiting instrumental ADL


name: Grade 2 Other Constitutional Symptoms, CTCAE


name: Radiation Recall Reaction (Dermatologic), CTCAE

description: A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent.


name: Type III Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the common pulmonary vein connects to the portal venous system through the diaphragm.


name: Malignant Outer Hair Sheath and Infundibulum Neoplasm

description: A malignant neoplasm that arises from the outer hair sheath and infundibulum.


Stage IIA Bone Sarcoma AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Grade 3 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 2 Penis Intra-Operative Injury, CTCAE


name: Grade 2 Pharynx Intra-Operative Injury, CTCAE


Grade 3 Hemorrhoids, CTCAE

description: Severe symptoms; invasive intervention indicated


Prostate Infection, CTCAE

description: A disorder characterized by an infectious process involving the prostate gland.


name: Grade 3 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Conjunctivitis, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


name: Upper Extremity Artery Intra-Operative Injury, CTCAE


name: Grade 4 Scrotum Intra-Operative Injury, CTCAE


Peripheral Nerve Injuries

description: Sensory or motor loss of peripheral nerve function due to a traumatic event. (ACC)


name: Myopathy Secondary to Glycogen Storage Disorder

description: A myopathy that was caused by a primary disorder of glycogen storage.


Lacrimal Gland Oncocytic Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal gland. It is characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm.


name: Grade 4 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Uterine Perforation, CTCAE

description: Invasive intervention indicated


name: Adverse Event Associated with Hemorrhage and Bleeding


name: Hodgkin's disease of intrapelvic lymph nodes

description: Stage I Hodgkin lymphoma involving the subdiaphragmatic region.


Grade 4 Vulval Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Intraoperative Arterial Injury, CTCAE

description: A finding of damage to an artery during a surgical procedure.


name: T Acute Lymphoblastic Leukemia, HOXA Dysregulated

description: T acute lymphoblastic leukemia characterized by an ectopic activation of the HOXA genes.


name: Grade 1 Gingiva Intra-Operative Injury, CTCAE


Vulvar Yolk Sac Tumor

description: A rare yolk sac tumor that arises from the vulva.


Bone marrow mastocytosis

description: A variant of indolent systemic mastocytosis that affects predominantly older males. It is characterized by a limited degree of bone marrow infiltration by clonal mast cells and an absence of skin involvement. The serum tryptase levels are normal or slightly elevated.


Radiation retinopathy

description: Injury of the retina following exposure to radiation.  The retinal injury results from occlusive microangiopathy caused by endothelial cell loss.


name: Grade 2 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage 0 Vulvar Cancer

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma). N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: Grade 2 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Jejunal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Chest Pain in Right Fourth Intercostal Space

description: The location of the chest pain is within the fourth intercostal space on the right side.


Grade 5 Laryngeal Obstruction, CTCAE

description: Death


Fibroblastic reticular cell neoplasm

description: A very rare dendritic cell sarcoma affecting the lymph nodes, spleen, and soft tissues. Morphologically it is similar to the interdigitating dendritic cell sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for cytokeratin and CD68.


Bacterial Toxemia

description: The condition resulting from the spread of bacterial products (toxins) by the bloodstream.


Nail Ridging, CTCAE

description: A disorder characterized by vertical or horizontal ridges on the nails.


Slipped extraocular muscle

description: Weakness of extraocular muscle function as a result of inadequate securing of the muscle to the sclera during strabismus surgery.


Excessive weight gain in pregnancy

description: In a woman with a normal weight pre-pregnancy body mass index (BMI), i.e. 18.5-24.9, the weight gained during pregnancy exceeds a total weight gain of 35 lbs. In a woman with an underweight pre-pregnancy body mass index (BMI), i.e. less than 18.5, the weight gained during pregnancy exceeds a total weight gain of 40 lbs. In a woman with an overweight pre-pregnancy body mass index (BMI), i.e. 25.0-29.9, the weight gained during pregnancy exceeds a total weight gain of 25 lbs. In a woman with an obese pre-pregnancy body mass index (BMI), i.e. greater than 30, the weight gained during pregnancy exceeds a total weight gain of 20 lbs. These standards are supported for the whole population irrespective of height, race or ethnicity.


name: Grade 3 Reproductive System and Breast Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 3 Hip Fracture, CTCAE

description: Severe pain; hospitalization or intervention indicated for pain control (e.g., traction); operative intervention indicated


name: Stage IIIA1 Fallopian Tube Cancer AJCC v8

description: Stage IIIA1 includes: T1/2, N1, M0. T1: T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 4 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Adult Acute Myelomonocytic Leukemia

description: An acute myelomonocytic leukemia occurring in adults.


Grade 2 Anemia, CTCAE

description: Hgb <10.0-8.0 g/dL; <6.2-4.9 mmol/L; <100-80g/L


Viremia

description: A laboratory test result indicating the presence of a virus in the blood.


name: Grade 5 Left Ventricular Diastolic Dysfunction, CTCAE


Locally Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Uterine Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the uterus.


Refractory WHO Grade 4 Glioma

description: A WHO grade 4 glioma that is resistant to treatment.


name: Clinical Stage IIA Cutaneous Melanoma AJCC v8

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Other Allergy and Immunology, CTCAE


Grade 4 Neonatal Fever, AE

description: A febrile adverse event in a newborn characterized by life-threatening consequences.


name: Grade 3 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Toothache, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Childhood Digestive System Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the digestive system and occurs during childhood.


Grade 5 Vaginal Anastomotic Leak, CTCAE

description: Death


name: Grade 2 Urinary Electrolyte Wasting, CTCAE


name: Grade 3 Esophageal Varices Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


Grade 1 Tracheal Obstruction, CTCAE

description: Partial asymptomatic obstruction on examination (e.g., visual, radiologic or endoscopic)


Grade 3 Urethral Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Deletion of Chromosome 3p Associated Meningioma

description: A meningioma that is associated with deletion of chromosomal arm 3p.


name: Grade 4 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Bone Intra-Operative Injury, CTCAE


name: Metastatic Peritoneal Malignant Mesothelioma

description: Peritoneal malignant mesothelioma that has spread from its original site of growth to another anatomic site.


name: Prostate Acinar Pseudohyperplastic Adenocarcinoma

description: Acinar prostate adenocarcinoma characterized by the presence of neoplastic large glands that resemble the benign, non-neoplastic prostate glands.


name: Grade 4 Neonatal Pulmonary Hemorrhage, AE

description: A pulmonary hemorrhage adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise.


name: Grade 5 Peripheral Motor Neuropathy, CTCAE

description: Death


Spermatogenic granuloma

description: A lump of extravasated sperm in the paratesticular region in men who have undergone vasectomy.


name: Grade 2 Other Hepatobiliary and Pancreas, CTCAE


Other Finding

description: An additional finding not previously noted.


Microbiology Laboratory Test Result

description: Clinical laboratory test findings associated with detection, identification or quantitation of microorganisms or products derived from them.


description: Malignant neoplasm occurring in immunodeficient patients.


Wound Dehiscence, CTCAE

description: A finding of separation of the approximated margins of a surgical wound.


Hydroxyproline Urine Increased

description: A laboratory test result indicating abnormally high concentration of hydroxyproline in the urine.


Renal granular cell carcinoma

description: A renal cell carcinoma with eosinophilic cytoplasm and high nuclear grade.  Granular cells can be seen in any subtype of renal cell carcinoma, including conventional clear cell carcinoma.  This term does not represent a specific subtype of renal cell carcinoma and should no longer be used.


name: Malignant Peripheral Nerve Sheath Tumor of the Skin

description: A malignant peripheral nerve sheath tumor that arises from the skin.


Coronary Venous Dissection

description: A tear within the wall of a coronary vein. (ACC)


name: Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin


Stage IVA Vulvar Cancer AJCC v8

description: Stage IVA includes: (T1-T2, N3, M0); (T3, Any N, M0). T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Grade 2 Reduction in Growth Velocity, CTCAE


name: Grade 5 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Neuralgia and Peripheral Nerve Pain, CTCAE


name: Chondromesenchymal hamartoma of chest wall

description: A rare benign lesion that arises from the rib cage and affects infants.  It results in the formation of a mass which is composed of spindle cells, cartilage, and hemorrhagic cysts.  Surgical resection is usually curative.


name: Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: A group of acute myeloid leukemias characterized by recurrent genetic abnormalities, mainly balanced translocations.  (WHO, 2001)


Immunoglobulin deposition disease

description: A mature B-cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease.


name: Cerebral Artery Intra-Operative Injury, CTCAE


name: Grade 3 Injury To Superior Vena Cava, CTCAE

description: Severe symptoms; limiting self care ADL; repair or revision indicated


name: Disorder of eye due to diabetes mellitus

description: A group of disorders affecting the eye in patients with diabetes mellitus. It includes cataract, glaucoma, retinopathy, and blindness.


Testicular Cancer by AJCC v8 Stage

description: A term that refers to the staging of testicular cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to postpubertal germ cell tumors of the testis and malignant sex cord-stromal tumors of the testis. It does not apply to spermatocytic tumors (no AJCC staging system), nonmalignant sex cord-/gonadal -stromal tumors (no AJCC staging system), prepubertal germ cell tumors (no AJCC staging system), hematolymphoid tumors (hematologic malignancies staging system), and paratesticular neoplasms (no AJCC staging system).  (from AJCC 8th Ed.)


name: Grade 3 Lung Intra-Operative Injury, CTCAE


name: Grade 2 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Pituitary Intra-Operative Injury, CTCAE


name: Grade 5 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hepatic Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Appendix Adenocarcinoma

description: Appendix adenocarcinoma that is resistant to treatment.


Uveitis, CTCAE

description: A disorder characterized by inflammation to the uvea of the eye.


name: Grade 1 Epstein-Barr Virus Infection Reactivation, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Decreased NCF2 Expression

description: An indication that the expression of NCF2 is lower than the normal range of values.


name: Grade 2 Upper Airway NOS Intra-Operative Injury, CTCAE


name: Grade 2 Bronchopulmonary Hemorrhage, CTCAE

description: Moderate symptoms; invasive intervention not indicated


Platelet Count Decreased, CTCAE

description: A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.


name: Grade 2 Eye NOS Intra-Operative Injury, CTCAE


name: Solar Radiation-Related Cutaneous Melanoma

description: Cutaneous melanoma that arises following exposure to solar radiation.


Stage II Vulva Cancer AJCC v6

description: Stage II includes: T2, N0, M0.  T2: Tumor confined to the vulva or vulva and perineum, more than 2cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


Thrombocytopenia 5

description: An autosomal dominant disorder characterized by decreased platelets, bleeding tendency, and mutation in the ETV6 gene. It is associated with an increased risk of developing hematologic malignancy.


name: Dermal Change Lymphedema or Phlebolymphedema, CTCAE


Grade 2 Pharyngolaryngeal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Silicon granuloma

description: A granuloma that forms in response to silicone exposure.


name: Genitourinary Leak Including Anastomotic Leak, CTCAE


Stage IVA Cervical Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


name: Grade 3 Muscle Weakness Right-Sided, CTCAE

description: Limiting self care ADL


Grade 1 Neonatal Sinus Tachycardia, AE

description: An adverse event in a newborn characterized by brief, self-limiting, episodes of sinus tachycardia; no care changes.


Grade 1 Hyperthyroidism, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 1 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 4 Urethra Intra-Operative Injury, CTCAE


Grade 3 Bronchospasm, CTCAE

description: Limiting self care ADL; supplemental oxygen indicated


name: Grade 1 White Blood Cell Decreased, CTCAE

description: <LLN-3000/mm3; <LLN-3.0 x 10e9/L


name: Grade 2 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Prolonged depressive adjustment reaction

description: Temporary but prolonged and maladaptive depressive signs and symptoms associated with a life event.


Grade 3 Anorectal Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Recurrent Paraganglioma

description: The reemergence of paraganglioma after a period of remission.


Microabscess

description: A very small, tiny abscess.


Grade 3 Photosensitivity, CTCAE

description: Erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs)


Stridor, CTCAE

description: A disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction.


name: Grade 5 Salivary Duct Inflammation, CTCAE

description: Death


name: Moderately Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of malignant cells exhibiting moderate differentiation.


Pleural Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the pleural cavity.


Wound Infection, CTCAE

description: A disorder characterized by an infectious process involving the wound.


Acute pulmonary embolism

description: An acute embolism to the pulmonary vasculature.


Very Severe Aplastic Anemia

description: Aplastic anemia that is characterized by bone marrow (BM) cellularity less than 25% (or less than 50% if BM is comprised of less than 30% hematopoietic cells), and two or more of the following: absolute neutrophil count of less than 200 per microliter; platelet count of less than 20,000 per microliter; or an absolute reticulocyte count of less than 20,000 per microliter.


Ventricular Arrhythmia, CTCAE 5.0

description: A disorder characterized by a dysrhythmia that originates in the ventricles.


name: Colon or Cecum or Appendix Fistula, CTCAE


name: Grade 1 Parotid Gland Intra-Operative Injury, CTCAE


name: Lingual Nerve Intra-Operative Injury, CTCAE


Cerebrovascular Insufficiency

description: A condition resulting in inadequate blood flow through the blood vessels supplying the brain, due to intrinsic disease of the vasculature.


name: Decreased Concomitant Drug Peak Blood Concentration

description: Decreased maximum (peak) concentration of a concomitant drug observed after its administration.


Appendix Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the appendix.


Grade 4 Scrotal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Metastatic Non-Cutaneous Melanoma

description: A non-cutaneous melanoma that has spread from its original site of growth to another anatomic site.


Childhood Large Cell Lymphoma

description: A large cell lymphoma occurring in childhood.


Refractory Esophageal Carcinoma

description: Esophageal carcinoma that is resistant to treatment.


name: Grade 3 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Bladder Spasm, CTCAE

description: Intervention not indicated


name: Grade 5 Edema of the Head and Neck, CTCAE


Ovulation Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.


Conjunctival Carcinoma

description: A carcinoma that arises from the conjunctiva.


Esophageal Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Grade 5 Neonatal Hypotension, AE

description: A hypotensive adverse event in a newborn which results in death.


Placental aromatase deficiency

description: An autosomal recessive condition that results in aromatase deficiency in the placenta, causing temporary virilization of the pregnant woman and virilization of her 46,XX fetus.


name: Grade 4 Metabolic or Respiratory Acidosis, CTCAE


name: Grade 4 Renal and Urinary Disorders - Other, Specify, CTCAE


name: Grade 4 Peripheral Motor Neuropathy, CTCAE


name: Invasive Large Nested Urothelial Carcinoma

description: A rare invasive urothelial carcinoma characterized by the presence of medium to large nests of malignant cells.


Refractory Malignant Germ Cell Tumor

description: Malignant germ cell tumor resistant to treatment.


name: Grade 2 Pancreas Intra-Operative Injury, CTCAE


Refractory Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that does not respond to treatment.


Non-Neoplastic Breast Disorder

description: A non-neoplastic disorder that affects the breast. Representative examples include fibrocystic disease, gynecomastia, mastitis, and adenosis.


High Grade Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia).


Grade 4 Pharyngeal Necrosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 3 Blurred Vision, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Purpura, CTCAE

description: A disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.


name: Transient myocardial ischemia of newborn

description: A condition characterized by a temporary imbalance between the oxygen supply and demand of the heart muscle in the newborn.


name: Grade 2 Abdomen NOS Intra-Operative Injury, CTCAE


Pregnancy Loss, CTCAE

description: Death in utero.


name: Grade 2 Gastrointestinal Leak NOS, CTCAE


name: Grade 4 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Laryngeal Mucositis, CTCAE

description: Death


Grade 3 Pharyngeal Necrosis, CTCAE

description: Inability to aliment adequately by GI tract; invasive intervention indicated; tube feeding or TPN indicated


Grade 2 Bronchospasm, CTCAE

description: Symptomatic; medical intervention indicated; limiting instrumental ADL


Grade 2 Chylous Ascites, CTCAE

description: Symptomatic; medical intervention indicated (e.g., fat-restricted diet); paracentesis or tube drainage indicated


Optic Nerve Disorder, CTCAE

description: A disorder characterized by involvement of the optic nerve (second cranial nerve).


name: Grade 2 Vas Deferens Stricture or Stenosis, CTCAE


Grade 1 Nail Infection, CTCAE

description: Localized, local intervention indicated


Refractory Adenovirus Infection

description: An adenovirus infection that does not respond to treatment.


name: Grade 2 Ureteric Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Unresectable Renal Pelvis and Ureter Urothelial Carcinoma

description: Renal pelvis and ureter urothelial carcinoma that is not amenable to surgical resection.


Grade 2 Diarrhea, CTCAE

description: Increase of 4-6 stools per day over baseline; moderate increase in ostomy output compared to baseline; limiting instrumental ADL


Grade 5 Neonatal Epileptic Seizure, AE

description: An adverse event in a newborn characterized by death related to electroencephalogram (EEG)-proven seizures.


name: Grade 4 Spermatic Cord Obstruction, CTCAE


name: Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Renal Colic, CTCAE

description: Mild pain not interfering with activity; nonprescription medication indicated


name: Adverse Drug Reaction to Systemic Antibiotic

description: A detrimental or unintended response associated with the use of a systemic antibiotic.


name: Grade 2 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Small Bowel Obstruction NOS, CTCAE


name: Grade 4 Cecum or Appendix Hemorrhage, CTCAE


Meningismus, CTCAE

description: A disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges.


Refractory Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that does not respond to treatment.


name: Grade 3 Atrioventricular Block Complete, CTCAE

description: Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker); new onset


name: Human Papillomavirus-Independent Cervical Adenocarcinoma In Situ

description: Cervical adenocarcinoma in situ not associated with human papillomavirus infection.


Bacteremia, CTCAE

description: A disorder characterized by the presence of bacteria in the blood stream.


name: Musculoskeletal Chest Pain due to Myositis

description: A condition in which there is musculoskeletal chest pain secondary to inflammation of the muscle tissue. (ACC/AHA)


name: Grade 2 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Hematologic Neoplasm with Germline ANKRD26 Mutation

description: An autosomal dominant disorder characterized by moderate thrombocytopenia and increased risk of developing myelodysplastic syndrome/acute myeloid leukemia. This disorder is characterized by germline mutations in ANKRD26, located on chromosome band 10p12.1. (WHO 2017)


name: Grade 5 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Early Unfavorable Hodgkin Lymphoma

description: An early Hodgkin lymphoma with unfavorable prognosis.


name: Grade 3 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Stage IIB Appendix Carcinoma AJCC v7

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood TdT Positive Acute Lymphoblastic Leukemia

description: TdT positive acute lymphoblastic leukemia that occurs during childhood.


Tendon Reflex Decreased, CTCAE

description: A disorder characterized by less than normal deep tendon reflexes.


Fetus in fetu

description: An exceptionally rare congenital abnormality in which a malformed and parasitic fetus is located within the body of its twin.


Grade 4 Ventricular Arrhythmia, CTCAE

description: Life-threatening consequences; hemodynamic compromise


name: Endometrioid adenocarcinoma, ciliated cell variant

description: An endometrioid adenocarcinoma arising from the endometrium, in which ciliated cells line the majority of the malignant glands.


name: Grade 2 Spermatic Cord Obstruction, CTCAE

description: Symptomatic; elective intervention indicated


Adult Acute Myeloblastic Leukemia

description: An acute myeloid leukemia occurring in adults.


name: Colon or Cecum or Appendix Necrosis, CTCAE


name: Infection and inflammatory reaction due to internal orthopedic fixation device

description: An infectious process involving an implanted medical device and the surrounding tissues.


Nonorganic Insomnia

description: Insomnia as a result of an extrinsic cause.


Pulmonary Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the lung and another organ or anatomic site.


Grade 3 Hepatic Failure, CTCAE

description: Asterixis; mild encephalopathy; drug-induced liver injury (DILI); limiting self care ADL


name: Non-Fatal Cardiopulmonary Arrest Cause Unknown, CTCAE


Grade 1 Hyperkeratosis, CTCAE

description: Present


name: Grade 5 Adult Respiratory Distress Syndrome, CTCAE

description: Death


name: Grade 1 Gastrointestinal Stoma Hemorrhage, CTCAE


name: Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


name: EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: An EBV-related lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder.


name: Low Grade Anal Canal Intraepithelial Neoplasia

description: Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit mild dysplasia (grade I intraepithelial neoplasia).


Urinary Tract Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of contents of the urinary tract.


Grade 4 Methemoglobinemia, CTCAE

description: Life-threatening consequences


Grade 1 Libido Increased, CTCAE

description: Present


name: Gallbladder Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of moderate atypia.


Osteosarcoma recurrent

description: The reemergence of osteosarcoma after a period of remission.


name: Grade 1 Voice Changes and Dysarthria, CTCAE


Grade 2 Blood Prolactin Abnormal, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Grade 3 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 1 Renal Calculi, CTCAE

description: Asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated


name: Acute Myeloid Leukemia with In-Frame bZIP CEBPA Mutation

description: An acute myeloid leukemia characterized by the presence of CEBPA bZIP domain mutation. It is associated with a favorable clinical outcome.


IgD Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgD monoclonal immunoglobulin in the blood or urine.


Chest wall cyst

description: A cystic lesion in the chest wall.


Borderline Resectable Mass

description: A tumor mass finding that refers to a continuum between resectable and locally advanced unresectable disease.


name: Stage II Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Antenatal Hydronephrosis

description: Hydronephrosis that occurs in a fetus.


Grade 4 Photosensitivity, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Infantile Apnea, AE

description: An adverse event in a newborn characterized by self-limiting apnea.


name: Stage IV Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Malignant Proliferating Pilar Tumor

description: A rare malignant neoplasm that arises from the outer root sheath of the hair follicle. It usually occurs in the scalp, face and trunk. Histopathology shows cords of malignant squamous cells infiltrating into the dermis.


Grade 3 Conduction Disorder, CTCAE

description: Symptomatic, urgent intervention indicated


name: Grade 4 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IB Bone Cancer AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 2 Anorgasmia, CTCAE

description: Inability to achieve orgasm adversely affecting relationship


name: Grade 3 Scrotum Intra-Operative Injury, CTCAE


Grade 3 Gallbladder Fistula, CTCAE

description: Invasive intervention indicated


name: Grade 3 Intraoperative Arterial Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Laryngeal Mucositis, CTCAE

description: Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL


name: Grade 4 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Infections and Infestations - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Depletion


Grade 1 Kidney Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Grade 4 Night Blindness, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


name: Platinum-Resistant Malignant Germ Cell Tumor

description: A malignant germ cell tumor that is resistant to platinum therapy.


name: Adult Unfavorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis that occurs during adulthood.


name: Grade 3 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Ureter Intra-Operative Injury, CTCAE


name: Grade 1 Small Intestinal Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 5 Pulmonary Fistula, CTCAE

description: Death


name: Grade 3 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Metastatic malignant neoplasm to conjunctiva

description: A malignant neoplasm that has spread to the conjunctiva from another anatomic site.


name: Anaplastic (Malignant) Intracranial Meningioma

description: An anaplastic meningioma that arises within the cranial cavity.


Grade 1 INR Increased, CTCAE

description: >1.2-1.5; >1-1.5 x baseline if on anticoagulation; monitoring only indicated


name: Hereditary factor XII deficiency disease

description: A rare autosomal recessive inherited bleeding disorder caused by deficiency of coagulation factor XII. It may be asymptomatic or manifest with bleeding.


Metastatic Vaginal Carcinoma

description: A carcinoma that arises from the vagina and has metastasized to another anatomic site.


name: Grade 1 Fallopian Tube Intra-Operative Injury, CTCAE


CTCAE v4 Grade 3

description: An adverse event that is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, e.g., getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet).


Grade 5 Gum Infection, CTCAE

description: Death


Grade 2 Anal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Osteoclastic Giant Cell-Rich Tumor of Bone

description: A benign, intermediate, or malignant bone tumor characterized by the presence of osteoclast-like giant cells. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.


name: Grade 2 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic endometrioid carcinoma

description: An endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Pulmonary Hypertension, CTCAE

description: Severe symptoms, associated with hypoxia, right heart failure; oxygen indicated


name: Grade 2 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


name: Recurrent Malignant Neoplasm of Multiple Primary Sites

description: Reemergence of a malignant neoplasm of multiple primary sites after a period of remission.


Grade 4 Anal Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Thalassemic Osteopathy

description: Bone disorders that present in thalassemia patients.


name: Grade 5 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Breast Fibrocystic Change, Proliferative Type without Atypia

description: Breast fibrocystic change characterized by the presence of epithelial cell hyperplasia.  There is no evidence of epithelial atypia.


name: Grade 2 Personality and Behavioral Change, CTCAE


Grade 1 Retinal Tear, CTCAE

description: No retinal detachment and treatment not indicated


Paronychia, CTCAE

description: A disorder characterized by an infectious process involving the soft tissues around the nail.


Cervical Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the cervix.


Grade 4 Duodenal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Cyanosis, CTCAE

description: A disorder characterized by a bluish discoloration of the skin and/or mucous membranes.


Low ADAMTS13 Activity

description: A finding indicating that a significantly lower than expected activity for the proteinase a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) is detected in a sample. This finding is associated with thrombotic thrombocytopenic purpura.


Granular Cell Astrocytoma

description: An astrocytoma characterized by the presence of large numbers of neoplastic cells with granular, PAS-positive cytoplasm. It is associated with an aggressive clinical course, even when the histologic features suggest a lower-grade astrocytoma.


name: High Grade Conjunctival Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the conjunctival epithelium.


Grade 3 Gum Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 2 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Pancreatic Duct Stenosis, CTCAE

description: Death


name: Intraoperative Reproductive System Injury

description: Damage to the reproductive organs during a surgical procedure.


name: Grade 5 Fallopian Tube Hemorrhage, CTCAE


Grade 2 Hip Fracture, CTCAE

description: Hairline fracture; mild pain; limiting instrumental ADL; non-operative intervention indicated


Grade 5 Portal Vein Thrombosis, CTCAE

description: Death


Nuclear Cataract Grade 2

description: A stage of nuclear sclerotic cataract marked by moderate yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


name: Grade 3 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Floaters, CTCAE

description: Symptomatic but not limiting ADL


Retinoblastoma, undifferentiated

description: A retinoblastoma composed of small, undifferentiated cells. It is often associated with necrotic changes.


Pain, CTCAE

description: A disorder characterized by the sensation of marked discomfort, distress or agony.


Grade 3 Tinnitus, CTCAE

description: Severe symptoms; limiting self care ADL


Malignant tumor, small cell type

description: A malignant neoplasm characterized by the presence of small atypical cells.


Stage IIC Prostate Cancer AJCC v8

description: Stage IIC includes: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Grade 4 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Duodenal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Urinary Fistula, CTCAE

description: A disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site.


name: Grade 3 Neonatal Pulmonary Hemorrhage, AE

description: An adverse event in a newborn characterized by hemorrhagic secretion in an endotracheal (ET) tube; with relevant increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation; requiring major change in ventilatory support or transfusion.


name: T Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

description: T-lymphoblastic leukemia/lymphoma in which further genetic/molecular characterization is not available.


Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma arising from the urinary bladder.  Clinical signs include hypertension and hematuria.


name: Adverse Event Associated with Ocular and Visual Systems


Grade 2 Night Blindness, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


name: Childhood Malignant Genitourinary System Neoplasm

description: A malignant neoplasm that affects the genitourinary system during childhood.


Broad Ligament Serous Adenocarcinoma

description: A rare serous adenocarcinoma that arises from the broad ligament.


Grade 5 Menorrhagia, CTCAE

description: Death


name: Grade 2 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Malignant Non-Hodgkin Lymphoma, Cleaved Cell


name: Vaginal Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present.


Cutaneous neurofibroma

description: A neurofibroma that grows along small branches of nerves in the dermis in patients with neurofibromatosis. It presents as a solid cutaneous tumor.


Esophageal adenocarcinoma recurrent

description: An esophageal adenocarcinoma which has reappeared after a period of remission or after presumed treatment.


Grade 2 Gastric Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Cervical Cancer by AJCC v7 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 7th edition.


Acute Myocardial Injury

description: Acute myocardial injury diagnosed by rise and fall in cardiac troponin above the 99th percentile of a reference population.


Stage IIA1 Cervical Cancer AJCC v9

description: Stage IIA1 includes: T2a1, N0, M0. T2a1: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Grade 4 Neutrophil Count Decreased, CTCAE

description: <500/mm3; <0.5 x 10e9/L


Hormone Treatment Failure

description: A lack of response to hormone therapy.


Conjunctival Spitz Nevus

description: A rare nevus that arises from the conjunctiva. It is characterized by the presence of large spindle-shaped or epithelioid melanocytes.


Prostate Undifferentiated Carcinoma

description: An invasive prostate carcinoma characterized by the presence of undifferentiated malignant cells.


Grade 3 Fibrinogen Decreased, CTCAE

description: <0.5-0.25 x LLN; if abnormal, 50-<75% decrease from baseline


Tinnitus, CTCAE 5.0

description: A disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking.


Actinomycotic granuloma

description: A granuloma that develops in response to Actinomycotic fungal infection.


name: Grade 2 Intraoperative Hepatobiliary Injury, CTCAE

description: Partial resection of injured organ/structure indicated


Refractory Liposarcoma

description: Liposarcoma that does not respond to treatment.


Stage IV Cervical Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0); IVB (Any T, Any N, MI). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M1: Distant metastasis. (AJCC 6th and 7th eds.)


name: Grade 1 Nails Intra-Operative Injury, CTCAE


Fall, CTCAE

description: A finding of sudden movement downward, usually resulting in injury.


name: Grade 4 Stoma GI Stricture or Stenosis, CTCAE


Grade 5 Device Related Infection, CTCAE

description: Death


name: Grade 5 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Aspartate Aminotransferase Increased, CTCAE

description: >3.0-5.0 x ULN if baseline was normal; >3.0-5.0 x baseline if baseline was abnormal


Grade 2 Seizure, CTCAE

description: Brief generalized seizure


Grade 4 Kidney Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Pancreatic Necrosis, CTCAE

description: Death


Grade 5 Hepatitis Viral, CTCAE

description: Death


name: Grade 3 Hepatobiliary Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Anaplastic Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered, characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


Grade 1 Neonatal Sinus Bradycardia, AE

description: An adverse event in a newborn characterized by brief, self-limiting, episodes of sinus bradycardia; no care changes.


Refractory Appendix Carcinoma

description: Appendix carcinoma that is resistant to treatment.


name: Grade 3 Upper Respiratory Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Alopecia, CTCAE

description: A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.


name: Grade 1 Left Ventricular Diastolic Dysfunction, CTCAE


Critical illness myopathy

description: Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation.


Grade 5 Bladder Infection, CTCAE

description: Death


name: Lugano Classification Limited Stage Adult Lymphoma AJCC v8

description: Limited stage adult lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


name: Childhood Acute Lymphoblastic Leukemia CNS 2 Toronto Guidelines v2

description: No clinical signs of CNS involvement and blasts in CSF and either: WBC < 5/μL CSF or WBC > or = 5/uL CSF and RBC > or = 10/uL CSF and WBC/RBC in CSF < or = 2x WBC/RBC in blood. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Perforation due to Lead

description: Penetration of a lead through a systemic vein, coronary vein, or the myocardium. (ACC)


Stage IIIC Appendix Carcinoma AJCC v8

description: Stage IIIC includes: Any T, N2, M0. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 1 Cranial Nerve II Neuropathy, CTCAE


Grade 3 Tumor Pain, CTCAE

description: Severe pain; limiting self care ADL


description: Trigeminal neuralgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Grade 1 Sacral Plexus Intra-Operative Injury, CTCAE


name: Grade 5 Genitourinary Stoma Prolapse, CTCAE


Portal Hypertension, CTCAE

description: A disorder characterized by an increase in blood pressure in the portal venous system.


name: Grade 2 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Laryngeal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 3 Genitourinary Stoma Stricture or Stenosis, CTCAE


Metastatic Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has spread from the original site of growth to another anatomic site.


Endometrial Neuroendocrine Carcinoma

description: A small cell or large cell neuroendocrine carcinoma arising from the endometrium.


name: Ampullary Flat Intraepithelial Neoplasia, High Grade

description: A non-polypoid, preinvasive neoplasm that arises from the ampulla of Vater.  It is characterized by the presence of high grade dysplasia.


name: Chronic Ocular Graft Versus Host Disease

description: Chronic graft versus host disease occurring in the eye.


Grade 2 Hyperlipidemia, CTCAE

description: Requiring pharmaceutical intervention


Injury Asphyxation

description: Acute compression of the thoracic cavity, causing  increased intrathoracic pressure and the backflow of blood from the right atrium and superior vena cava into the brachiocephalic and jugular veins, with resulting stagnation of blood flow and subsequent localized blood-oxygen desaturation in the head and neck.


Grade 3 Hypertension, CTCAE

description: Adult: Systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg; medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; Pediatric and adolescent: Systolic and/or diastolic > 5 mmHg above the 99th percentile


name: Grade 1 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Residual Tumor

description: Tumor cells that remain in the body following cancer treatment.


name: Grade 4 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Esophageal Basal Cell Hyperplasia

description: A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation.  Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium.  Its association with an increase risk of developing squamous cell carcinoma remains controversial.


Grade 1 Chylous Ascites, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 4 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Enterocolitis Infectious, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated


name: Grade 1 Blood Corticotrophin Decreased, CTCAE


Grade 3 Anal Stenosis, CTCAE

description: Symptomatic and severely altered GI function; non-emergent operative intervention indicated; TPN or hospitalization indicated


Grade 2 Scrotal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Pathologic Stage IIIA Cutaneous Melanoma AJCC v8

description: Stage IIIA includes: T1a/b-T2a, N1a or N2a, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Diffuse Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system. The majority of these tumors are found in the brainstem.


name: Unresectable Gastroesophageal Junction Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the gastroesophageal junction and is not amenable to surgical resection.


name: Adult Acute Myeloid Leukemia without Maturation

description: An acute myeloid leukemia without maturation occurring in adults.


name: Gravid Uterus Adjusted Maternal Body Weight Gain

description: The amount of maternal body weight gained over a period of time where the weight at the end of the interval is adjusted for the gravid uterus weight. This is derived by subtracting the maternal body weight adjusted for the gravid uterus from the total maternal body weight.


Grade 2 Shingles, CTCAE

description: Local infection with moderate symptoms; oral intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Atrial Fibrillation, CTCAE

description: Non-urgent medical intervention indicated


Advanced Angiosarcoma

description: An angiosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Basal Cell Carcinoma

description: Basal cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of urethra

description: An undifferentiated carcinoma arising from the urethra.


Grade 4 Testicular Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Conjunctival Blue Nevus

description: A benign melanocytic neoplasm that arises from the conjunctiva. It is characterized by the presence of dendritic and spindle-shaped melanocytes in the subepithelial connective tissue. It presents as a dark brown or black, slightly elevated conjunctival lesion.


Intraoperative Endocrine Injury

description: Damage to an endocrine gland during a surgical procedure.


Bilateral anophthalmos of eyes

description: A rare congenital abnormality characterized by the complete absence of ocular tissue in both orbits.


Salivary Gland Fistula, CTCAE

description: A disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site.


name: acute megakaryoblastic leukemia in relapse

description: The reemergence of acute megakaryoblastic leukemia after a period of remission.


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood retinoblastoma according to the Toronto childhood cancer staging guidelines v2.


name: Grade 4 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Esophageal Pain, CTCAE

description: Mild pain


name: Grade 4 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Esophagitis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Localized Lymphoma

description: A lymphoma that is confined to a specific site without evidence of spread to other anatomic sites.


malignant enteroglucagonoma

description: A glucagon-producing malignant endocrine neoplasm. It displays vascular invasion and metastasizes to other anatomic sites.


name: Grade 4 Superior Vena Cava Syndrome, CTCAE

description: Life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery)


name: Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Hoarseness, CTCAE

description: Severe voice changes including predominantly whispered speech


name: Stage III Renal Pelvis and Ureter Cancer AJCC v7

description: Stage III includes: T3, N0, M0. T3: For renal pelvis only: tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  For ureter only: tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Anal cancer recurrent

description: The reemergence of anal carcinoma after a period of remission.


name: Cytomegalovirus Infection Reactivation, CTCAE

description: A disorder characterized by the reactivation of cytomegalovirus (CMV).


name: Grade 4 Middle Ear Intra-Operative Injury, CTCAE


name: Grade 2 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Pneumonitis, CTCAE

description: Death


Gender identity disorder

description: A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).


Thoracic Meningocele

description: A congenital abnormality in the thoracic region of the spine in which the meninges protrude through a defect in the spinal column.


name: Grade 3 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Unresectable Glioneuronal and Neuronal Tumors

description: Glioneuronal and neuronal tumors that are not amenable to surgical resection.


Grade 1 Oral Pain, CTCAE

description: Mild pain


name: Grade 3 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Refractory Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that is resistant to treatment.


name: Grade 3 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Locally Advanced Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 5 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Growth Hormone Abnormal, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Reflux

description: An abnormal backward flow of a body fluid.


Ileal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the ileal wall.


Infant T Acute Lymphoblastic Leukemia

description: A T-acute lymphoblastic leukemia that occurs in infancy.


Grade 2 Cecal Infection, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Metastatic Urethral Carcinoma

description: A urethral carcinoma that has spread to another anatomical site.


name: Mediastinum Intra-Operative Injury, CTCAE


name: FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


Mucositis Oral, CTCAE

description: A disorder characterized by ulceration or inflammation of the oral mucosal.


Cataract, CTCAE 5.0

description: A disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated.


name: Beta-2-Microglobulin Greater than 3 g/mL

description: A laboratory test result indicating that beta-2-microglobulin is present in a sample at concentrations exceeding 3 g/mL.


name: Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

description: Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene).


name: Grade 5 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Neonatal Fever, AE

description: An adverse event in a newborn characterized by elevation of body temperature above normal due to the production of more heat than the body is able to dissipate.


Insomnia, CTCAE 5.0

description: A disorder characterized by difficulty in falling asleep and/or remaining asleep.


Grade 5 Neonatal Bradyarrhythmia, AE

description: A bradyarrhythmia adverse event in a newborn which results in death.


name: Grade 4 Cranial Nerve IV Intra-Operative Injury, CTCAE


Refractory Mucosal Melanoma

description: Mucosal melanoma that is resistant to treatment.


Glucokinase-Associated Hyperinsulinism

description: Hyperinsulinism due to activating mutation(s) in the gene GCK, encoding glucokinase.


Grade 4 Neonatal Pneumothorax, AE

description: A pneumothorax adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise (e.g. tension pneumothorax); urgent major care change required.


Childhood Grade I Meningioma

description: A grade I meningioma that occurs during childhood.


Grade 4 Rectal Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 1 Accessory Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Pelvic Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the pelvis.


name: Adverse Event Associated with Sexual and Reproductive Function


name: Grade 1 Blood Gonadotrophin Abnormal, CTCAE


name: Serum Glutamic Oxaloacetic Transaminase, CTCAE


Grade 4 Cervicitis Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Associated with the Teeth, CTCAE


Grade 3 Duodenal Perforation, CTCAE

description: Invasive intervention indicated


Grade 3 Serum Amylase Increased, CTCAE

description: >2.0-5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic


Serum Bicarbonate Decreased

description: A laboratory test result which indicates decreased levels of bicarbonate in the serum.


name: Stage 0 Childhood Retinoblastoma by Toronto Guidelines v2

description: The tumor is confined to the globe. Enucleation has not been performed. (The patient is treated "conservatively" with either focal therapies or chemotherapy.) (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Bloating, CTCAE

description: Symptomatic, decreased oral intake; change in bowel function


name: Grade 3 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Larynx Intra-Operative Injury, CTCAE


Childhood Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during childhood.


Stage IIIA Prostate Cancer AJCC v8

description: Stage IIIA includes: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Invasive Bladder Conventional Urothelial Carcinoma

description: Invasive bladder urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


Grade 2 Nystagmus, CTCAE

description: Moderate symptoms; limiting instrumental ADL


FNCLCC Sarcoma Grade 1

description: A sarcoma with a total score of 2 or 3 according to the FNCLCC guidelines.


Refluxing Megaureter

description: A megaureter that demonstrates retrograde urine flow without ureteral obstruction.


Grade 5 Photosensitivity, CTCAE

description: Death


name: Grade 3 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Prolapse of Intestinal Stoma, CTCAE

description: Recurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental ADL


Grade 2 Periorbital Infection, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


name: Grade 4 Small Bowel Obstruction NOS, CTCAE


name: Grade 3 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Malignant urinary tract neoplasm metastatic

description: The spread of a malignant neoplasm to the urinary tract from an adjacent or distant anatomic site.


Prolonged QTc Interval, CTCAE

description: An adverse event characterized by an abnormally long interval between the start of the Q wave and the end of the T wave in the heart's electrical cycle, corrected for heart rate.


name: Grade 3 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Grade 1 Neonatal Pneumothorax, AE

description: An adverse event in a newborn characterized by radiological evidence of pneumothorax; no clinical signs; no care change required.


Grade 5 Joint Infection, CTCAE

description: Death


transvestism

description: A disorder characterized by recurrent sexual urges, fantasies, or behaviors in a heterosexual male involving cross-dressing.


Grade 4 Death Neonatal, CTCAE

description: Neonatal loss of life


name: adenocarcinoma of gallbladder with squamous metaplasia

description: An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.


name: Grade 3 Adult Respiratory Distress Syndrome, CTCAE

description: Present with radiologic findings; intubation not indicated


Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for Hodgkin lymphomas based on the Ann Arbor classification criteria.


Complicated malaria

description: Acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected).


name: Papillary transitional cell carcinoma, non-invasive

description: A transitional cell carcinoma characterized by a papillary growth pattern and lack of stromal invasion.


name: Non-Keratinizing Primary Intraosseous Squamous Cell Carcinoma -Solid Type

description: A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, lack of prominent keratinization, infiltration of the marrow spaces, and osseous resorption.


name: Grade 3 Encephalomyelitis Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated