name: Grade 4 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Neonatal Intraventricular Hemorrhage, AE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An adverse event in a newborn characterized by hemorrhage occupying less than 50% of ventricular volume without ventricular dilatation greater than 4mm above the 97th percentile.


Elevated EBV DNA

description: A finding indicating elevated concentrations of Epstein-Barr virus DNA in a sample.


name: Cervical intraepithelial neoplasia grade 1

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Diffuse KATP-Associated Hyperinsulinism

description: KATP-associated hyperinsulinism affecting all pancreatic beta cells.


Recurrent Acute Erythroid Leukemia

description: The reemergence of acute erythroid leukemia after a period of remission.


name: Anxiety disorder due to a general medical condition

description: An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.


Aspiration, CTCAE

description: A disorder characterized by inhalation of solids or liquids into the lungs.


name: Grade 2 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Stage IVB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Basal cell carcinoma - keratotic

description: A variant of basal cell carcinoma with the architectural features of a nodular basal cell carcinoma.  It is characterized by the formation of keratin (horn cysts) in the center of the tumor islands.  Dystrophic calcification is frequently present.


name: Grade 5 Pyramidal Tract Dysfunction, CTCAE


Grade 4 Bronchopleural Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Complication

description: Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.


Anaplastic Diencephalic Astrocytoma

description: An anaplastic astrocytoma that occurs in the diencephalon.


name: Grade 4 Respiratory Tract Hemorrhage NOS, CTCAE


Sclerosing Blue Nevus

description: A dendritic blue nevus characterized by the presence of prominent sclerotic stromal collagen.


description: A reactive proliferation of the conjunctival squamous epithelium not associated with glandular elements.


name: Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia


Recurrent Lymphoid Leukemia

description: The reemergence of lymphoid leukemia after a period of remission.


name: Grade 2 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Lymphoproliferative Disease Associated with Primary Immune Disorder

description: A lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder. The primary immune disorders most frequently associated with lymphoproliferative disorders are ataxia-telangiectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, X-linked lymphoproliferative disease, Nijmegen breakage syndrome, hyper-IgM syndrome, and autoimmune lymphoproliferative syndrome. (WHO 2017)


Grade 4 Leukocytosis, CTCAE

description: Clinical manifestations of leucostasis; urgent intervention indicated


Grade 2 Bladder Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Radiating Chest Pain Along Right Lower Sternal Border

description: The location of the radiating chest pain is along the right lower sternal border.


name: Recurrent Histiocytic and Dendritic Cell Neoplasm

description: The reemergence of a histiocytic and dendritic cell neoplasm after a period of remission.


Grade 1 Pancreatic Fistula, CTCAE

description: Asymptomatic


Stage III Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Vascular anomaly of eyelid

description: Any non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels of the eyelid.


name: Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IIIA Esophageal Adenocarcinoma AJCC v7

description: Stage IIIA includes: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Oligospermia, CTCAE

description: A disorder characterized by a decrease in the number of spermatozoa in the semen.


name: Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


name: Grade 3 Appendix Intra-Operative Injury, CTCAE


verrucous carcinoma of vagina

description: A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders.


Elevated LDH

description: An indication that the concentration of lactate dehydrogenase found in a sample is higher than previous noted or above the normal range.


Grade 1 Injection Site Reaction, CTCAE

description: Tenderness with or without associated symptoms (e.g., warmth, erythema, itching)


name: Grade 4 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Injection Site Reaction, CTCAE

description: Death


Grade 5 Laryngeal Stenosis, CTCAE

description: Death


name: Grade 4 Blood Bilirubin Increased, CTCAE

description: >10.0 x ULN if baseline was normal; >10.0 x baseline if baseline was abnormal


name: Grade 1 Lower Extremity Intra-Operative Injury, CTCAE


name: Testicular Seminoma with Syncytiotrophoblastic Cells

description: A testicular seminoma characterized by the presence of syncytiotrophoblastic giant cells.


Peritoneal Implant

description: Deposits of borderline, malignant, and rarely benign tumors, usually from the ovary, on the peritoneal surface.


Grade 1 Anorgasmia, CTCAE

description: Inability to achieve orgasm not adversely affecting relationship


Resectable Cutaneous Melanoma

description: Cutaneous melanoma that is amenable to surgical resection.


name: Infections and Infestations - Other, Specify, CTCAE


Sinusitis, CTCAE

description: A disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.


name: Grade 2 Recurrent Laryngeal Nerve Palsy, CTCAE

description: Moderate symptoms


name: Grade 4 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Cranial Nerve VI Intra-Operative Injury, CTCAE


name: Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: An acute myeloid leukemia with recurrent genetic abnormalities occurring in adults.


High Grade Liver Dysplastic Nodule

description: A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.


Sporadic Gastric Adenocarcinoma

description: A primary adenocarcinoma of the stomach in a patient with no family history of gastric cancer or inherited high risk mutations.


Subacute Placental Infarction

description: A focus of necrotic placental parenchyma with moderate hyalinization and fibrosis with partial absence of the necrotic chorionic villi, which is frequently 3-5 days of duration.


K ATP Permanent Neonatal Diabetes

description: K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.


name: Grade 5 Superior Vena Cava Syndrome, CTCAE

description: Death


Resectable Sarcoma

description: Sarcoma that is amenable to surgical resection.


Periorbital Edema, CTCAE

description: A disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face.


description: Thrombotic microangiopathy of the gastrointestinal tract.


name: Grade 3 Renal and Urinary Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Accident

description: An unforeseen and unplanned event or circumstance frequently causing loss or injury.


name: Clinical Stage I Cutaneous Melanoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Grade 2 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Laryngeal Nerve Dysfunction, CTCAE


name: Grade 3 Hemolytic Uremic Syndrome, CTCAE

description: Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)


name: Grade 2 Cranial Nerve VIII Intra-Operative Injury, CTCAE


Advanced Adnexal Carcinoma

description: Adnexal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Endometrial cystic hyperplasia

description: Benign endometrial hyperplasia characterized by the presence of cystically dilated glands.


name: Pulmonary Fibrosis Radiographic Changes, CTCAE


name: Grade 2 Pancreas Exocrine Enzyme Deficiency, CTCAE


name: Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Childhood Skin Neoplasm

description: A benign, intermediate, or malignant neoplasm that affects the skin and occurs during childhood.


Grade 1 Otitis Externa, CTCAE

description: Localized, local intervention indicated


Imaging Finding

description: The result of an evaluation technique using a visual display of structural or functional patterns of organs or tissues that is performed to determine the presence, absence, or degree of a condition.


Meniscal Cyst

description: A cyst located at the periphery of the meniscus.


Grade 1 Hypotension, CTCAE

description: Asymptomatic, intervention not indicated


name: Grade 3 Neuralgia and Peripheral Nerve Pain, CTCAE


name: Malignant Lymphoma, Histiocytic, Diffuse


name: Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Papillary mucinous cystadenoma

description: A usually benign and less often low malignant potential cystic epithelial neoplasm composed of cells which contain intracytoplasmic mucin. It is characterized by the presence of papillary structures.


name: Acute gonococcal infection of lower genitourinary tract

description: A gonococcal infection of the lower urinary tract that is rapid in onset.


name: Musculoskeletal Chest Pain due to Rib Injury

description: A condition in which there is musculoskeletal chest pain secondary to trauma to one or more ribs. (ACC/AHA)


name: Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Bronchial Infection, CTCAE

description: A disorder characterized by an infectious process involving the bronchi.


Parathyroid Clear Cell Hyperplasia

description: A hyperplasia of the clear cells of the parathyroid gland.


Paradental Cyst

description: An inflammatory collateral cyst that arises on the lower third molars. (WHO 2017)


name: FIGO Stage II Gestational Trophoblastic Tumor

description: Lesion invades outside of the uterus, but it is limited to the genital structures.


Malignant Paraganglionic Neoplasm

description: A paraganglioma that metastasizes to regional or distant anatomic sites.  Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Grade 1 Lymphedema, CTCAE

description: Trace thickening or faint discoloration


name: Grade 4 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Grade 2 Ileus, CTCAE

description: Symptomatic; altered GI function; bowel rest indicated


Grade 1 Hematuria, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 5 Laryngitis, CTCAE

description: Death


Stage II Prostate Cancer AJCC v7

description: Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Stage IV Cervical Cancer FIGO 2018

description: The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)


Encephalopathy of Prematurity

description: A condition affecting premature infants characterized by white matter injury, which is frequently accompanied by neuronal/axonal disease, that may affect all brain parenchymal structures and is due to a combination of destructive processes as well as maturational and trophic disturbances.


Metastatic Bladder Adenocarcinoma

description: Bladder adenocarcinoma that has spread from its original site of growth to other anatomic sites.


Grade 2 Alcohol Intolerance, CTCAE

description: Present


name: Grade 3 Prolonged Intubation After Pulmonary Resection, CTCAE


Grade 4 Tracheitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Severe Aplastic Anemia

description: Life-threatening anemia associated with a high risk of infection or bleeding.


name: Refractory Extracranial Malignant Solid Neoplasm

description: An extracranial malignant solid neoplasm that is resistant to treatment.


Flat adenoma

description: An adenoma of the gastrointestinal tract mucosa which grossly and morphologically does not appear as an elevated or polypoid lesion.


name: Grade 2 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Aorta Artery Intra-Operative Injury, CTCAE


name: Pathologic Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N2, M0, Any G); (T2, N1, M0, Any G); IIIB: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Adult Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in adults.


name: Grade 2 Conjunctiva Intra-Operative Injury, CTCAE


name: Grade 2 Gastrointestinal Stoma Hemorrhage, CTCAE


name: Grade 5 Colon Stricture or Stenosis, CTCAE


name: Disseminated Intravascular Coagulation, CTCAE

description: A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.


Early Stage Endometrial Carcinoma

description: A stage term referring to endometrial carcinoma that is confined to the uterus.


name: Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an ampulla of Vater neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to well-differentiated neuroendocrine tumors of the ampulla of Vater. Carcinomas of the ampulla of Vater, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not included in this staging system. (from AJCC 8th Ed.)


name: Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Sustained Atrial Tachyarrhythmia Related to COVID-19 other than Atrial Fibrillation or Atrial Flutter

description: A supraventricular tachycardia, including AV nodal re-entry, orthodromic re-entrant tachycardia, multifocal atrial tachycardia, other atrial tachycardia that lasts more then 30 seconds in a patient with probable or confirmed acute COVID-19.


Grade 1 Hypophosphatemia, CTCAE

description: Laboratory finding only and intervention not indicated


name: Ductal Eccrine Carcinoma with Spindle Cell Elements

description: A variant of ductal eccrine carcinoma with spindled cell appearance.


Pancreatic carcinoma recurrent

description: The reemergence of pancreatic carcinoma after a period of remission.


Seropositive rheumatoid arthritis

description: Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Spitzoid melanoma

description: A cutaneous melanoma that is associated with genomic alterations observed in Spitz nevus and Spitz melanocytoma. It shares histopathological and clinical features with Spitz melanocytoma.


Grade 2 Fall, CTCAE

description: Symptomatic; noninvasive intervention indicated


Acquired Rickets

description: Rickets that is caused by vitamin D deficiency, hypocalcemia, or renal failure.


Diffuse Glioma

description: A glioma that has diffusely infiltrated the surrounding central nervous system tissues.


name: Grade 4 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Urethra Stricture or Stenosis, CTCAE


Acquired Phrenic Nerve Injury

description: Damage to the phrenic nerve that was not present at birth.


name: Grade 4 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Non-Infectious Wound Complication, CTCAE


name: Grade 1 Trigeminal Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 1 Cranial Nerve VI Intra-Operative Injury, CTCAE


name: Vulvar Squamous Intraepithelial Lesion, HPV-Associated

description: An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by maturation abnormalities and nuclear hyperchromasia that are confined to the basement membrane.


Grade 1 Enterovesical Fistula, CTCAE

description: Asymptomatic


name: Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8

description: Stage IC includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


name: Rhabdomyosarcoma with TFCP2 Rearrangement

description: An aggressive, high-grade rhabdomyosarcoma characterized by TFCP2 rearrangement that results either in TFCP2-FUS or TFCP2-EWSR1 fusion gene formation. It affects young adults and arises from bone and less frequently soft tissue. It predominantly affects the craniofacial bones. Histologically, it usually shows a biphasic pattern with spindle and epithelioid cell areas. It is associated with poor prognosis.


name: Childhood Mixed Cellularity Classic Hodgkin Lymphoma

description: Mixed cellularity classic Hodgkin lymphoma occurring in childhood.


name: Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Cebocephaly

description: A congenital abnormality characterized by a malformation of the head. The eyes are hypoteleric and the nose may be absent or misshapen (small, flattened, single nostril) and defective.


Stage I Skin Cancer

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness, Clark level equal or greater than IV, and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Grade 2 Presyncope, CTCAE

description: Present (e.g., near fainting)


Eyelid Function Disorder

description: A disorder characterized by impaired eyelid function.


Wrist Fracture, CTCAE

description: A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken.


Stage IVB Prostate Cancer AJCC v8

description: Stage IVB includes: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


Grade 5 Neonatal Diarrhea, AE

description: A diarrhea adverse event in a newborn which results in death.


Stage IIC Testicular Cancer AJCC v8

description: Stage IIC includes: (Any pT/TX, N3, M0, S0); (Any pT/TX, N3, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


name: Grade 3 Nasopharynx Intra-Operative Injury, CTCAE


name: More Than Two Separate Tumor Masses Present in the Same Organ

description: A finding indicating the presence of more than two separate tumor masses in the same organ.


Disinfectant Exposure

description: Environmental, occupational, or consumer-based exposure to epoxy compounds and other volatile chemicals associated with production, handling and use of disinfectants.


name: Grade 4 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Oral Dysesthesia, CTCAE

description: Disabling pain; tube feeding or TPN indicated


Grade 4 Uterine Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 3 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Peripheral Arterial Ischemia, CTCAE


name: Grade 3 Other Pulmonary and Upper Respiratory, CTCAE


Grade 2 Platelets, CTCAE

description: <75,000 - 50,000/mm(3); <75.0 - 50.0 x 10e9 /L


Glossopharyngeal Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the glossopharyngeal nerve (ninth cranial nerve).


Breast Columnar Cell Lesion

description: A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma.  These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units.  Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ.  Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known.


Lymphoma, Mixed-Cell

description: An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes.


name: Lugano Classification Stage III Adult Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Pre-Gestational Diabetes

description: Diabetes diagnosed before current pregnancy. (reVITALize)


name: Grade 5 Other Blood and Bone Marrow, CTCAE


Type II Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Adenovirus DNA Viremia

description: A laboratory test result indicating the presence of adenovirus DNA in the blood.


name: Grade 2 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Degenerated Schwannoma

description: A schwannoma that is characterized by degenerative changes such as hyalinization, hemorrhage, calcification and cystic change.


Retinopathy of Prematurity, AE

description: An adverse event characterized by a retinal condition of very immature infants that may be characterized by non-vascularized retinae that may lead to neovascularization, scarring, retinal detachment, and blindness.


name: Advanced Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 5 Enterocolitis, CTCAE

description: Death


name: Grade 5 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hypothermia, CTCAE

description: <=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation)


name: Grade 2 Hypoxic Ischemic Encephalopathy, AE

description: An adverse event in a newborn characterized by mild transient clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event;  necessitating observation and additional care.


Lymph Gland Infection, CTCAE

description: A disorder characterized by an infectious process involving the lymph nodes.


name: Unresectable Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that is not amenable to surgical resection.


Factor II Inactivation

description: Presence of inactivating antibodies to prothrombin (factor II) in the blood.


name: Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8

description: Stage IB includes: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. (AJCC 8th ed.)


name: Grade 1 Small Bowel Obstruction NOS, CTCAE


name: Fetus Small for Gestational Age with Abnormal Doppler

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and has abnormal Doppler studies.


Grade 3 Urine Output Decreased, CTCAE

description: Adult: Oliguria (<80 ml in 8 hr); Infants: < 0.5 mL/kg per hour for 24 hours; Children: < 500 mL/1.73 m2 body surface area per day


name: Grade 2 Large Intestinal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Grade 2 Hypopituitarism, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 5 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Cranial Nerve VIII Neuropathy, CTCAE


name: Grade 4 Urethra Stricture or Stenosis, CTCAE


name: Grade 3 Otitis External Ear Non Infectious, CTCAE


Grade 3 Hepatic Pain, CTCAE

description: Severe pain; limiting self care ADL


Grade 3 Dysesthesia, CTCAE

description: Severe sensory alteration; limiting self care ADL


Anorgasmia, CTCAE

description: A disorder characterized by an inability to achieve orgasm.


name: Grade 5 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Metastatic squamous cell carcinoma to skin

description: A squamous cell carcinoma that has spread to the skin from another anatomic site.


name: Peripheral neuropathy due to and following antineoplastic therapy

description: Any disorder affecting the peripheral nerves resulting from exposure to chemotherapeutic agents.


name: Grade 4 Cranial Nerve XI Intra-Operative Injury, CTCAE


Finding

description: Clinical, laboratory or molecular evidence, or absence of evidence of disease.


name: Grade 5 Gastrointestinal Leak NOS, CTCAE


Depression, CTCAE

description: A disorder characterized by melancholic feelings of grief or unhappiness.


name: Type I Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.


Recurrent Diffuse Midline Glioma

description: The reemergence of diffuse midline glioma after a period of remission.


Corneal Ulcer, CTCAE

description: A disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber.


name: Grade 3 Thorax Soft Tissue Necrosis, CTCAE


Childhood Solid Neoplasm

description: A solid neoplasm (e.g., carcinoma, sarcoma) occurring in children.


name: Salivary Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic Low Grade Glioma

description: Low grade glioma that has spread from its primary site to another anatomic site.


name: Grade 5 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Unresectable Diffuse Glioma

description: A diffuse glioma that is not amenable to surgical resection.


name: Grade 3 Non-Myocardial Visceral Arterial Ischemia, CTCAE


name: Substance-Induced Persisting Amnestic Disorder

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the persisting effects of substance use. The memory impairment persists beyond the usual duration of substance intoxication or withdrawal.


name: Pulmonary Artery Intra-Operative Injury, CTCAE


name: Grade 3 Cerebral Artery Intra-Operative Injury, CTCAE


name: Grade 3 Cerebrospinal Fluid Leakage, CTCAE

description: Severe symptoms; medical intervention indicated


Platinum-Resistant Urothelial Carcinoma

description: Urothelial carcinoma that is resistant to platinum therapy.


Liver Lymphangiomatosis

description: Multiple lymphangiomas that affect the liver and other anatomic sites. Although histologically benign, diffuse lymphangiomatosis that affects the liver and multiple organs has a poor prognosis.


name: Supratentorial Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain in which the genetic analysis for fusion genes involving ZFTA or YAP1 genes was unsuccessful or not reported.


Thoracic Nodule

description: A nodular lesion that develops in the chest wall.


name: Grade 1 Tongue Intra-Operative Injury, CTCAE


Stage II Merkel Cell Carcinoma AJCC v7

description: Stage II includes: IIA: (T2/T3, pN0, M0), IIB: (T2/T3, cN0, M0), and IIC: (T4, N0, M0).  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


name: Grade 2 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pharyngeal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site.


Mixed subtype adenocarcinoma of lung

description: The most frequently seen morphologic variant of lung adenocarcinoma characterized by a mixture of architectural patterns, including acinar, papillary, bronchioloalveolar, and solid pattern.


name: Grade 3 Acute Vascular Leak Syndrome, CTCAE


Vital Exhaustion

description: A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.


Arachnoiditis, CTCAE

description: A disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space.


Hemorrhagic cyst

description: A cyst containing blood.


name: Grade 4 Lymphocyte Count Decreased, CTCAE

description: <200/mm3; <0.2 x 10e9/L


name: Recurrent Anal Canal Squamous Cell Carcinoma

description: The reemergence of anal canal squamous cell carcinoma after a period of remission.


name: Grade 2 Other Sexual Reproductive Function, CTCAE


Peripheral Nerve Infection, CTCAE

description: A disorder characterized by an infectious process involving the peripheral nerves.


Stage IIA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

description: A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


Cranial Nerve Infection, CTCAE

description: A disorder characterized by an infectious process involving a cranial nerve.


Grade 2 Biliary Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Grade 1 Wheezing, CTCAE

description: Detectable airway noise with minimal symptoms


name: Stage III Extragonadal Non-Seminomatous Germ Cell Tumor


name: Grade 1 Blood Bicarbonate Decreased, CTCAE

description: <LLN and no intervention initiated


Vaginal Adenoid Basal Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of nests of basaloid cells with focal glandular formations.


name: Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 1 Meninges Intra-Operative Injury, CTCAE


Nose Deformities, Acquired

description: A non-congenital malformation of the nose.


Retinoblastoma by AJCC v8 Stage

description: A term that refers to the staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to central nervous system component of "trilateral retinoblastoma" (is staged according to the classification for brain and spinal cord), retinoma (or retinocytoma) (no AJCC staging system), and medulloepithelioma (no AJCC staging system). (from AJCC 8th Ed.)


Serious Adverse Drug Reaction

description: A noxious and unintended response to a medicinal product occurring at any dose that results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in a persistent or significant disability/incapacity, or results in a congenital anomaly/birth defect.


name: Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of moderate epithelial atypia.


name: Grade 3 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Bullous Dermatitis, CTCAE

description: Death


Grade 3 Endophthalmitis, CTCAE

description: Systemic intervention; hospitalization indicated


name: Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Unresectable Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that is not amenable to surgical resection.


Grade 3 Breast Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; severe infection; axillary adenitis


Grade 2 Seroma, CTCAE

description: Symptomatic; simple aspiration indicated


name: Grade 3 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Thoracoschisis

description: A congenital fissure of the thoracic wall.


name: Grade 4 Edema of the Head and Neck, CTCAE


Grade 3 Hypophosphatemia, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


name: Grade 5 Intraoperative Ocular Injury, CTCAE

description: Death


name: Grade 2 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Intraepithelial Neoplasia in Barrett Esophagus

description: Glandular intraepithelial neoplasia arising in Barrett esophagus.


Grade 3 Hyperkalemia, CTCAE

description: >6.0-7.0 mmol/L; hospitalization indicated


Small plaque parapsoriasis

description: A variant of parapsoriasis in which the plaques are small.


name: Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Chylothorax, CTCAE

description: Death


Gallbladder Cribriform Carcinoma

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate with a cribriform growth pattern.


name: Grade 1 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Anorexia, CTCAE

description: Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated


name: Grade 2 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Aspiration, CTCAE

description: Altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen)


name: Grade 4 Lung Intra-Operative Injury, CTCAE


name: Parathyroid Intra-Operative Injury, CTCAE


name: Grade 4 Gastrointestinal Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Accelerated Phase Myeloproliferative Neoplasm

description: Rapid progression of a myeloproliferative neoplasm, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


name: Refractory EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: EBV-associated lymphoproliferative disease with primary immunodeficiency that is resistant to treatment.


Overt Primary Myelofibrosis

description: Primary myelofibrosis characterized by reticulin or collagen fibrosis in the bone marrow. The bone marrow is usually normocellular or hypocellular. Myeloblasts account for less than 10% of the bone marrow cells. Atypical megakaryocytes are present.


name: Grade 3 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Grade 1 Serum Amylase Increased, CTCAE

description: >ULN-1.5 x ULN


Perineal Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus.


Grade 3 Pericarditis, CTCAE

description: Pericarditis with physiologic consequences (e.g., pericardial constriction)


Flashing Lights, CTCAE

description: A disorder characterized by a sudden or brief burst of light.


Atelectasis, CTCAE

description: A disorder characterized by the collapse of part or the entire lung.


name: Grade 5 Supraventricular Tachycardia, CTCAE

description: Death


name: Grade 1 Fever Without Neutropenia, CTCAE


name: Left Ventricular Diastolic Dysfunction, CTCAE

description: An adverse event characterized by impaired functioning of the left ventricle of the heart during the diastole phase of the cardiac cycle.


Radiating Chest Pain in Sternum

description: The location of the radiating chest pain is in the middle of the anterior wall of the thorax, bounded by the clavicles, above, and with the cartilages of the first seven ribs, along the sides.


Reduced WAS Protein Expression

description: An indication that reduced expression of Wiskott-Aldrich Syndrome protein (WASP; WASp) has been detected in a sample.


name: Stage IIIC2 Uterine Corpus Cancer AJCC v7

description: Stage IIIC2 includes: T1-T3, N2, M0. T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue.  N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Grade 3 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Abnormal Blood Gonadotrophin

description: A laboratory test result which indicates abnormal levels of gonadotrophin hormone in the blood.


Laryngeal Obstruction, CTCAE

description: A disorder characterized by blockage of the laryngeal airway.


name: Grade 4 Alkaline Phosphatase Increased, CTCAE

description: >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


name: Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 1 Hyperuricemia, CTCAE

description: >ULN without physiologic consequences


Acute Myeloid Leukemia with del(12p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 12 [del(12p)].


Mucosal-Dominant Pemphigus Vulgaris

description: A subtype of pemphigus vulgaris in which lesions are predominantly found on mucosal membranes with relative sparing of cutaneous tissues.


name: Grade 3 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 4 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Guillain-Barre Syndrome, CTCAE

description: Life-threatening consequences; urgent intervention indicated; intubation


Cervical Glandular Neoplasm

description: A benign, malignant, or precancerous neoplasm that arises from the glandular epithelium of the cervix. Representative examples include endocervical polyp, cervical adenocarcinoma, and cervical glandular intraepithelial neoplasia.


Thromboembolic Event, CTCAE

description: A disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream.


name: Grade 5 Esophagus Stricture or Stenosis, CTCAE


Drug Exposure

description: Contact with drug.


Grade 4 Anorectal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Metastatic Bladder Micropapillary Urothelial Carcinoma

description: Bladder micropapillary urothelial carcinoma that has spread to another anatomic site.


Retinal Tear, CTCAE

description: A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters.


name: Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8

description: Advanced stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Grade 5 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IIA Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


name: Grade 3 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Behavioral insomnia of childhood

description: A childhood disorder characterized by difficulty initiating and maintaining sleep due to negative sleep associations, refusal to go to bed, and/or repeated attempts to delay bedtime.


Grade 1 Wound Infection, CTCAE

description: Localized, local intervention indicated


name: Adverse Event Associated with Pulmonary and Upper Respiratory Systems


name: Malignant Central Nervous System Germ Cell Tumor

description: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics.  Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma.


Hodgkin's lymphoma of CNS

description: A Hodgkin lymphoma that arises from the central nervous system.


name: Grade 2 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Laryngeal Nerve Dysfunction, CTCAE


name: Grade 1 Biliary Tree NOS Intra-Operative Injury, CTCAE


name: Grade 2 Bone Intra-Operative Injury, CTCAE


Grade 3 Aortic Injury, CTCAE

description: Severe symptoms; limiting self care ADL; repair or revision indicated


name: Grade 3 Trachea Obstruction and Stenosis, CTCAE


Grade 3 Toothache, CTCAE

description: Severe pain; limiting self care ADL


Vaginal Mucinous Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma.


Posterior Subcapsular Cataract Grade 1

description: A stage of posterior subcapsular cataract characterized by 3% of the posterior capsule obscured by opacity. (Modified LOCS II)


name: Grade 1 Other Allergy and Immunology, CTCAE


Infant Acute Lymphoblastic Leukemia

description: An acute lymphoblastic leukemia that occurs in infancy.


Brachial Plexopathy, CTCAE 5.0

description: A disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.


name: Simple Endometrial Hyperplasia without Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is absent.


Grade 5 Fracture, CTCAE

description: Death


name: Locally Advanced Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 3 Jejunum Intra-Operative Injury, CTCAE


name: Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Neonatal Deformity

description: A congenital anatomic abnormality manifested during the neonatal period.


name: Stage IIIB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 4 Pulmonary Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Vitreous Hemorrhage, CTCAE

description: Intervention not indicated


name: Grade 4 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervicitis Infection, CTCAE

description: A disorder characterized by an infectious process involving the uterine cervix.


Breast Papillary Ductal Hyperplasia

description: Benign papillary proliferation within the ductal system of the breast parenchyma.


name: Grade 3 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Benign Urinary Tract Neoplasm

description: A neoplasm that arises from the organs that comprise the urinary tract and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 5 Rectal Ulcer, CTCAE

description: Death


Somatic-Type Malignancy

description: A malignant non-germ cell component that typically develops secondarily within a germ cell tumor. The malignant cellular component is usually sarcomatous or carcinomatous.


name: Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Intraoperative Urinary Injury, CTCAE


Stage IIB Pancreatic Cancer AJCC v8

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Postoperative Spindle Cell Nodule of the Bladder

description: A benign, reactive lesion of the bladder, occurring status post bladder instrumentation; histologic exam demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the bladder wall without atypia or necrosis.


Microinvasive Anal Carcinoma

description: Anal carcinoma with minimal stromal invasion.


Subgaleal hemorrhage

description: Bleeding between the scalp and the periosteum.


Melanoma of Unknown Primary

description: A melanoma which has metastasized from an unknown primary anatomic site.


Unresectable Malignant Neoplasm

description: A malignant neoplasm which is not amenable to surgical resection.


CTCAE v4 Grade 4

description: An adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken.


Grade 1 Abdominal Distension, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IV Osteosarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Grade 4 Multi-Organ Failure, CTCAE

description: Life-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis)


name: Grade 3 Blood Gonadotrophin Abnormal, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 2 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Neonatal apneic attack

description: Apnea occurring during the neonatal period.


Grade 4 Colonic Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Sneezing, CTCAE

description: A disorder characterized by the involuntary expulsion of air from the nose.


name: Locally Advanced Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IIIB Appendix Carcinoma AJCC v7

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  T4: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invades other organs or structures.  N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Dialysis Catheter Embolism

description: An obstruction of a vessel caused by a detached fragment of an indwelling dialysis catheter.


Grade 3 Erectile Dysfunction, CTCAE

description: Decrease in erectile function (frequency/rigidity of erections) but erectile intervention not helpful (e.g., medication or mechanical devices such as penile pump); placement of a permanent penile prosthesis indicated (not previously present)


Grade 2 Injury To Jugular Vein, CTCAE

description: Repair or revision not indicated


name: Grade 1 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Pathologic Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Grade 2 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Fusion-Negative Rhabdomyosarcoma

description: A rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


name: Grade 3 Spermatic Cord Stricture or Stenosis, CTCAE


name: Grade 1 Central Nervous System Necrosis, CTCAE


name: Metastatic Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread to another anatomical site.


name: Transplant-Related Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises in a patient with a history of organ transplantation.


Refractory Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma that is resistant to treatment.


name: Grade 5 Left Ventricular Systolic Dysfunction, CTCAE

description: Death


name: Grade 4 Abdomen Soft Tissue Necrosis, CTCAE


Reinfection

description: A second infection by the same pathogen that follows a period of recovery.


Immunotoxicity

description: Toxicity that impairs or damages the immune system.


name: Acute Myeloid Leukemia with Mutated TP53

description: Acute myeloid leukemia characterized by the presence of TP53 gene mutations. There are 20% or more blasts in bone marrow or peripheral blood.


Accessory Urethral Gland Neoplasm

description: A benign or malignant, primary or metastatic neoplasm affecting the accessory urethral gland.


Grade 2 Retinopathy, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


name: Grade 4 Heart Intra-Operative Injury, CTCAE


name: Grade 4 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage II Gallbladder Cancer AJCC v6

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.)


name: Grade 3 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Ampulla of Vater Undifferentiated Carcinoma

description: An aggressive carcinoma arising from the ampulla of Vater.  Morphologically, it is characterized by the presence of malignant epithelial cells without evidence of glandular or squamous differentiation.  Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.


name: Possible Adverse Event Attribution to Product or Procedure

description: Possible adverse event relationship to study product or procedure is defined when there is less clear temporal association between product or procedure administration and adverse event, and other etiologies of the event are also possible.


Grade 5 Wound Infection, CTCAE

description: Death


name: Clinical Stage II Retinoblastoma AJCC v8

description: Stage II includes: cT4a, cN0, cM0, Any H. cT4a: Radiologic evidence of retrobulbar optic nerve involvement or thickening of optic nerve or involvement of orbital tissues. cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Grade 4 Bronchopulmonary Hemorrhage, CTCAE

description: Life-threatening consequences; intubation or urgent intervention indicated


Peripheral Hemangioblastoma

description: A hemangioblastoma that arises from peripheral nerves or extraneural tissues.


Non-Ossifying Fibroma

description: A tumor histologically indistinguishable from, but larger than, benign fibrous histiocytoma of bone.


Digitalis toxicity

description: Acute CNS, visual, GI, and cardiac disturbances caused by an overdose of, or intolerance to, the cardiac glycoside, digitalis.


Grade 1 Dry Mouth, CTCAE

description: Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min


Grade 2 Uterine Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Hodgkin's Paragranuloma Involving Spleen

description: An obsolete term that includes cases currently classified as nodular lymphocyte predominant Hodgkin lymphoma with splenic involvement.


Stage IB1 Cervical Cancer AJCC v8

description: Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 4 Pancreatitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Intracranial Hemorrhage, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IIA Cervical Cancer AJCC v8

description: Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 3 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Liver Radiation Injury

description: Radiation injury of the liver.


name: Grade 2 Sacral Plexus Intra-Operative Injury, CTCAE


BRCA-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in a gene of the BRCA family.


Grade 2 Ovarian Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Grade 4 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Kidney Infection, CTCAE

description: Death


Wood Dust Exposure

description: Environmental or occupational exposure to granular solids generated when timber is processed, such as when it is chipped, sawed, turned, drilled or sanded.


name: Recurrent Low Grade Endometrioid Adenocarcinoma

description: The reemergence of low-grade endometrioid adenocarcinoma after a period of remission.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol.


name: Grade 3 Vagina Intra-Operative Injury, CTCAE


name: Grade 2 Neuroendocrine ACTH Deficiency, CTCAE


Grade 1 Vaginal Inflammation, CTCAE

description: Mild discomfort or pain, edema, or redness


Grade 3 Duodenal Fistula, CTCAE

description: Invasive intervention indicated


Benign Apocrine Neoplasm

description: An epithelial neoplasm that arises from the apocrine glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 3 Conjunctiva Intra-Operative Injury, CTCAE


Non-Neoplastic Tracheal Disorder

description: A non-neoplastic disorder that affects the trachea.  Representative examples include tracheitis, tracheal agenesis, and tracheal atresia.


Gastroblastoma

description: A very rare biphasic tumor arising in the gastric muscularis propria (usually of the antrum), generally in boys and young men. It is associated with MALAT1-GLI1 gene fusion. (WHO 2019)


Grade 3 Constipation, CTCAE

description: Obstipation with manual evacuation indicated; limiting self care ADL


Cheilognathoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip and upper jaw.


Villous Adenoma of the Urinary Tract

description: An exophytic glandular neoplasm of the urinary tract, morphologically similar to its intestinal counterpart. It usually arises from the bladder and urachus. It often coexists with in situ or infiltrating bladder adenocarcinoma.


Primary Cutaneous NUT Adnexal Carcinoma

description: A very rare carcinoma that arises from adnexal structures in the skin. It is characterized by mutations and rearrangement of the NUT gene. It presents as a papular or nodular lesion and has been described in the hand, shoulder, trunk, and lower limb. Histologically, there is a proliferation of malignant epithelial cells in the dermis and/or subcutaneous tissue. The tumor cells display round nuclei with prominent single nucleoli. Features include the presence of small round ducts and foci of abrupt keratinization.


Hemoglobin Trait

description: A condition in which a person is heterozygous for a globin gene, with a one normal allele and one defective allele.


name: Grade 5 Neonatal Intraventricular Hemorrhage, AE

description: An intraventricular hemorrhage adverse event in a newborn which results in death.


HIV lipodystrophy

description: A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat.  It is associated with antiretroviral therapy.  Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs.


Cortical Cataract Grade 1

description: A stage of cortical cataract characterized by 10% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Stage I Uterine Corpus Cancer AJCC v6

description: Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Acute synovitis

description: An acute inflammation of a synovial membrane. It is associated with swelling and pain in the affected area.


Stage IIB Anal Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Mucosal Melanoma

description: Mucosal melanoma that has spread from its primary site to another anatomic site.


name: Recurrent Childhood Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma in childhood after a period of remission.


Grade 3 Confusion, CTCAE

description: Severe disorientation; limiting self care ADL


name: Malignant neoplasm arising from pre-existing spiradenocylindroma

description: A carcinoma that arises in a spiradenocylindroma.


name: Grade 3 International Normalized Ratio of Prothrombin Time, CTCAE


name: Grade 2 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of high grade dysplasia.


Restrictive Cardiomyopathy, CTCAE

description: A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility.


Grade 1 Oral Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Lithium Induced Birth Defect

description: Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy.


Hematologic Toxicity

description: A toxicity that impairs or damages the hematologic system.


name: Grade 4 Jugular Vein Intra-Operative Injury, CTCAE


name: Metastatic Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Platinum-Refractory Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing platinum therapy.


Factor XII Inactivation

description: Presence of inactivating antibodies to factor XII in the blood.


name: Papillary cystadenoma, borderline malignancy

description: A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells forming papillary structures with an absence of stromal invasion.


Grade 1 Bladder Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Toxicity due to Psychiatric Drugs

description: Toxicity that develops due to the administration of psychiatric medications.


Elevated MHC Class II

description: A finding indicating elevated concentrations of MHC class II in a sample.


name: Grade 4 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Metastatic Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Benign Outer Hair Sheath and Infundibulum Neoplasm

description: A neoplasm that arises from the outer hair sheath and infundibulum. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Grade 5 Intestinal Stoma Leak, CTCAE

description: Death


Lymphoma, Intermediate-Grade

description: An antiquated term that refers to a non-Hodgkin lymphoma with intermediate grade histologic features.


Olfactory Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the olfactory nerve (first cranial nerve).


name: Grade 4 Prostate Intra-Operative Injury, CTCAE


Non-Neoplastic Splenic Disorder

description: A non-neoplastic disorder that affects the spleen.


Grade 5 Cervicitis Infection, CTCAE

description: Death


Grade 5 Gastric Stenosis, CTCAE

description: Death


name: Grade 4 Non-Myocardial Visceral Arterial Ischemia, CTCAE


Grade 3 Euphoria, CTCAE

description: Severe mood elevation (e.g., hypomania)


SUR1-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the ABCC8 gene result in hyperinsulinism.


Grade 4 Peritoneal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Fever Without Neutropenia, CTCAE


Non-Malignant Nodule

description: A usually circumscribed and non-metastasizing nodular mass.


name: Stage II Adult Diffuse Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Physical Examination Abnormal Finding

description: An indication or description of any abnormal findings as a result of a physical examination.


Acute Myeloid Leukemia with del(5q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 5 [del(5q)].


name: Grade 4 Infusion Site Extravasation, CTCAE


Stabbing Pain

description: An intense sensation of discomfort or distress that is sharp and feels as though a knife has penetrated an anatomical location.


Tissue Rarefaction

description: A morphologic finding indicating reduced tissue density.


name: Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB-MYH11

description: An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of acute myeloid leukemia has a favorable prognosis.  (WHO, 2001)


name: Grade 2 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Gastroparesis, CTCAE

description: Moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention


name: Mucosal Melanoma of the Female Genital Tract

description: A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract.


Grade 2 Ovarian Rupture, CTCAE

description: Symptomatic and intervention not indicated


name: immune effector cell-associated neurotoxicity syndrome, grade 1

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 7, 8, or 9 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken spontaneously.


name: Grade 5 Intraoperative Arterial Injury, CTCAE

description: Death


name: Grade 2 Urinary Tract NOS Intra-Operative Injury, CTCAE


name: Gastrointestinal Leak Including Anastomotic Leak, CTCAE


name: Grade 1 Acoustic Nerve Disorder NOS, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Metastatic Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread from its original site of growth to another anatomic site.


name: Gestational Trophoblastic Tumor by FIGO Stage


name: IgG4-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG4.


name: Transitional Cell Intraepithelial Neoplasia


Grade 4 Pneumonitis, CTCAE

description: Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Abscess of axilla

description: A collection of pus that has formed in the axilla.


Atheroembolism of renal arteries

description: A cholesterol plaque embolus that has become lodged in the renal vasculature.


name: Malignant Lacrimal Drainage System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the lacrimal drainage system.


Grade 2 Eczema, CTCAE

description: Moderate; topical or oral intervention indicated; additional medical intervention over baseline indicated


Parasite-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific parasite as the causative agent.


Spongioblastoma, Polar

description: A lesion characterized by the presence of neoplastic neuroepithelial cells with palisading nuclei. This lesion implies a morphologic growth pattern and it is not considered a clinicopathological entity.


name: Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant small cells.


Atrophy of breast

description: Involution of the breast parenchyma.


name: Grade 3 Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Regional Childhood Retinoblastoma by Toronto Guidelines v2

description: Orbital extension or regional lymph nodes involvement. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Monoclonal B-Cell Lymphocytosis

description: A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma.


Hypomagnesemia, CTCAE

description: A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood.


Recurrent Adenocarcinoma

description: An adenocarcinoma that has recurred after a period of remission.


name: intraepithelial glandular neoplasia of cervix

description: A neoplastic process that affects the glandular epithelial cells of the cervix.  There is no evidence of invasion.  It is classified as low or high grade.


Gastric Ulcer, CTCAE

description: A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the stomach.


name: Grade 4 Other Growth and Development, CTCAE


Grade 2 Extrapyramidal Disorder, CTCAE

description: Moderate involuntary movements; limiting instrumental ADL


name: External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Advanced Childhood Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 4 Non-Fatal Cardiopulmonary Arrest Cause Unknown, CTCAE


name: Grade 3 Lymphocyte Count Increased, CTCAE


name: Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Keratinizing Primary Intraosseous Squamous Cell Carcinoma-Solid Type

description: A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, keratin production, infiltration of the marrow spaces, and osseous resorption.


name: Grade 3 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Advanced Squamous Cell Carcinoma

description: Squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Radiation-Related Angiosarcoma

description: A malignant vascular neoplasm arising in an anatomic site exposed to radiation therapy.


name: Grade 5 Prostate Stricture or Stenosis, CTCAE


Grade 3 Facial Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 2 Lingual Nerve Intra-Operative Injury, CTCAE


name: Nutritional Vitamin D Deficiency Rickets

description: Nutritional rickets due to dietary deficiency of vitamin D.


name: Grade 3 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Mitral Valve Disease, CTCAE

description: A disorder characterized by a defect in mitral valve function or structure.


Grade 3 Ventricular Arrhythmia, CTCAE

description: Urgent intervention indicated


Ureteral Kinking

description: The folding of a ureter, which results in the impediment of urine flow.


Grade 1 Localized Edema, CTCAE

description: Localized to dependent areas, no disability or functional impairment


Grade 2 Lipohypertrophy, CTCAE

description: Covering 10-30% BSA and associated tenderness; limiting instrumental ADL


Grade 5 Depression, CTCAE

description: Death


Urethral caruncle

description: A benign, granulomatous lesion that results from the eversion of a portion of the distal urethra, most often at the posterior edge.


name: Metabolism and Nutrition Disorders, CTCAE


name: Bone Growth Limb Length Discrepancy, CTCAE


name: Soft Tissue NOS Intra-Operative Injury, CTCAE


name: Grade 4 Pharyngeal Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 2 Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


name: Grade 3 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatic Precancerous Condition

description: A pathologic process that arises from the pancreas and has the potential to evolve into a malignant neoplasm.


Grade 2 Conduction Disorder, CTCAE

description: Non-urgent medical intervention indicated


name: Grade 5 Neutrophils and Granulocytes, CTCAE


name: Grade 3 Vas Deferens Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Grade 1 Glaucoma, CTCAE

description: Less than 8 mmHg of elevated intraocular pressure (EIOP); no visual field deficit


Crack

description: A break or fissure in a structure.


Stage III Appendix Carcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T3, N1, M0); (T4, N1, M0); IIIC: (Any T, N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission.


Dry Eye, CTCAE

description: A disorder characterized by dryness of the cornea and conjunctiva.


Acute rheumatic endocarditis

description: Inflammation of the endocardium in acute rheumatic heart disease.


name: Grade 2 Acute Vascular Leak Syndrome, CTCAE


name: Grade 5 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Spindle Cell Sarcoma

description: Spindle cell sarcoma that is resistant to treatment.


Stage I Vulvar Cancer AJCC v6

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.).


name: Gastointestinal Stoma Intra-Operative Injury, CTCAE


name: Hodgkin's Disease, Lymphocyte Depletion, Diffuse Fibrosis

description: A lymphocyte depleted Hodgkin lymphoma characterized by the presence of diffuse fibrosis and a few Hodgkin and Reed-Sternberg cells.


Grade 5 Intracranial Hemorrhage, CTCAE

description: Death


Refractory Ampulla of Vater Carcinoma

description: Ampulla of Vater carcinoma that is resistant to treatment.


name: Acute Myeloid Leukemia with EZH2 Mutation

description: An acute myeloid leukemia associated with EZH2 gene mutation.


name: Grade 3 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage II Pancreatic Cancer AJCC v6 and v7

description: Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension. T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis. N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Visual Pathway Melanocytoma

description: A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve.


name: Grade 1 Neonatal Culture Positive Sepsis, AE

description: An adverse event in a newborn characterized by a positive blood culture positive; no care change indicated (e.g. contamination suspected).


name: Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Metastatic Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that has spread from its original site of growth to other anatomic sites.


name: Recurrent Childhood Acute Lymphoblastic Leukemia

description: The reemergence of acute lymphoblastic leukemia in childhood after a period of remission.


name: Grade 4 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Childhood Diffuse Astrocytoma, MYBL1-Altered

description: A rare diffuse astrocytoma, MYBL1-altered that occurs during childhood.


Appendix Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix. It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


Grade 4 Jejunal Obstruction, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Upper Respiratory Infection, CTCAE

description: A disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea).


Cat bite

description: A wound received from the teeth of a cat.


name: Grade 5 Intraoperative Neurological Injury, CTCAE

description: Death


Vaginal intraepithelial neoplasia

description: A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue.  It is classified as low- or high-grade intraepithelial neoplasia.


Recurrent Sarcoma

description: The reemergence of sarcoma after a period of remission.


name: Grade 2 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


name: Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


Hemoglobin Increased, CTCAE

description: A finding based on laboratory test results that indicate increased levels of hemoglobin above normal.


name: Grade 1 Urethral Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Dizziness, CTCAE 5.0

description: A disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking.


Locally Advanced Glioma

description: Glioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Infective conjunctivitis

description: An infectious process affecting the conjunctiva.


name: Grade 5 Abdomen Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Acute Cerebrovascular Accidents

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system.


name: Surgical and Medical Procedures - Other, Specify, CTCAE


Childhood Grade III Meningioma

description: A grade III meningioma that occurs during childhood.


name: Refractory Juvenile Myelomonocytic Leukemia

description: Juvenile myelomonocytic leukemia that is resistant to treatment.


name: Grade 4 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 4 Somnolence, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Benign Lymphoproliferative Disorder

description: A proliferation of lymphocytes without atypia seen in infections, hypersensitivity reactions or autoimmune diseases.


name: Grade 2 Retroperitoneum Hemorrhage, CTCAE


Bronchial Epithelial Hyperplasia

description: Hyperplasia of the bronchial epithelial cells.  It is often associated with squamous metaplasia.


name: Grade 4 Glomerular Filtration Rate, CTCAE


name: Grade 2 Serum Glutamic Oxaloacetic Transaminase, CTCAE


name: Grade 2 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Inverted Squamous Cell Papilloma

description: A benign epithelial neoplasm characterized by an endophytic growth, papillary pattern, and proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


name: Refractory Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that is resistant to treatment.


Amenorrhea, CTCAE

description: A disorder characterized by the abnormal absence of menses for at least three consecutive menstrual cycles


description: A non-neoplastic disorder arising in an anatomic site exposed to radiation.


Refractory Malignant Solid Neoplasm

description: A malignant solid neoplasm that does not respond to treatment.


Unresectable Bone Sarcoma

description: Bone sarcoma that is not amenable to surgical resection.


name: Childhood Nodular Sclerosis Classic Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in childhood.


name: Stage IIB Ampulla of Vater Cancer AJCC v8

description: Stage IIB includes: T3b, N0, M0. T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Advanced Malignant Testicular Germ Cell Tumor

description: A malignant testicular germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Phrenic nerve lesion

description: Intermittent, incomplete or complete paralysis with or without tremors to any of the organs or body parts innervated by the phrenic nerve.


Proteinuria, CTCAE 5.0

description: A disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.


name: Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Esophageal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 1 Local Complication of Device and Prosthesis, CTCAE


name: Immune Effector Cell Associated Neurotoxicity Syndrome Grade 5

description: Death due to Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) where another cause is not the primary determinant.


Childhood Astrocytoma

description: An astrocytoma that occurs during childhood.


name: Advanced Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Gastroesophageal Junction Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Grade 4 Typhlitis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 1 Papulopustular Rash, CTCAE

description: Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness


Grade 1 Anorectal Infection, CTCAE

description: Localized, local intervention indicated


name: Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8

description: Stage 0 includes: Tis(LAMN), N0, M0. Tis(LAMN): Low-grade appendiceal mucinous neoplasm confined by the muscularis propria. Acellular mucin or mucinous epithelium may invade into the muscularis propria. T1 and T2 are not applicable to LAMN. Acellular mucin or mucinous epithelium that extends into the subserosa or serosa should be classified as T3 or T4a, respectively. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Hodgkin's disease nodular sclerosis recurrent

description: The reemergence of nodular sclerosis classic Hodgkin lymphoma after a period of remission.


Grade 4 Esophageal Obstruction, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Metastatic Urachal Urothelial Carcinoma

description: Bladder urachal urothelial carcinoma that has spread to another anatomic site.


Stage IIIC Prostate Cancer AJCC v8

description: Stage IIIC includes: Any T, N0, M0, PSA: Any, Grade Group 5. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


Stage III Prostate Cancer AJCC v6

description: Stage III includes: T3, N0, M0, Any G. T3: Tumor extends through the prostatic capsule.  T3a: Extracapsular extension (unilateral or bilateral).  T3b: Tumor invades seminal vesicle(s). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Grade 3 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Cramping Pain

description: A sense of discomfort or distress that is spasmodic or clenching.


name: Metastatic Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


name: Stage IV Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Hematogenous metastases or spread beyond abdomen at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Night Blindness, CTCAE

description: A disorder characterized by an inability to see clearly in dim light.


name: Grade 5 Other Renal or Genitourinary, CTCAE


Grade 3 Mucositis Oral, CTCAE

description: Severe pain; interfering with oral intake


Recurrent Childhood Large Cell Lymphoma

description: The reemergence of childhood large cell lymphoma after a period of remission.


Grade 2 Cyanosis, CTCAE

description: Present


name: Grade 3 Liver Dysfunction or Failure by Clinical Classification, CTCAE


Stage III Uterine Corpus Cancer

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1-T3, N1/N2, M0); IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Grade 2 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Anal Fistula, CTCAE

description: Invasive intervention indicated


Infantile Myofibroma

description: A benign, localized, nodular and well-circumscribed neoplasm seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.


Radiologic Finding

description: Imaging results obtained through a radiology procedure.


name: Grade 1 Injury To Superior Vena Cava, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Vulvar Large Cell Neuroendocrine Carcinoma

description: A high grade neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant large cells.


Grade 3 Neonatal Sinus Bradycardia, AE

description: An adverse event in a newborn characterized by persistent sinus bradycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Grade 3 Pharyngeal Fistula, CTCAE

description: Invasive intervention indicated


name: Grade 2 Non-Myocardial Visceral Arterial Ischemia, CTCAE


name: Grade 4 Vascular Disorders - Other, Specify, CTCAE


name: Grade 3 Bronchopulmonary Hemorrhage NOS, CTCAE


BAP1-inactivated melanocytoma

description: A cutaneous melanocytoma caused by the inactivation of BAP1 tumor suppressor gene. It is characterized by the presence of a predominantly intradermal proliferation of large epithelioid melanocytes with a large amount of eosinophilic cytoplasm, and vesicular nuclei with prominent nucleoli. Progression to melanoma is infrequent.


name: Recurrent Malignant Female Reproductive System Neoplasm

description: The reemergence of a malignant female reproductive system neoplasm after a period of remission.


Grade 2 Hypophosphatemia, CTCAE

description: Oral replacement therapy indicated


name: Grade 2 Heart Intra-Operative Injury, CTCAE


Bilateral Carcinoma

description: A carcinoma that affects both sides of an organ in a simultaneous or non-simultaneous manner.


Obstructed labor

description: A physical barrier to the natural delivery of a baby.


Stage IVA Bone Cancer AJCC v8

description: Stage IVA includes: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Metastasis in the lung. (AJCC 8th ed.)


name: Grade 4 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE