Advanced Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


name: Grade 4 Cranial Nerve VIII Intra-Operative Injury, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Intermediate Osteogenic Neoplasm

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A non-metastasizing, locally aggressive, bone-forming neoplasm.


Paratesticular Epithelial Neoplasm

description: A benign, borderline, or malignant epithelial neoplasm that arises from the paratesticular structures.


name: Grade 5 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Duodenal Infection, CTCAE

description: Death


name: Grade 1 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Dialysis dementia

description: A severe, often fatal encephalopathy which has been attributed to accumulation in the brain of aluminum from dialysate prepared with inadequately purified water.


name: Grade 5 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Malignant Lymphoma, Large Cell, Cleaved and Non-Cleaved

description: Antiquated term describing follicular (nodular) or diffuse non-Hodgkin lymphomas that are composed of a mixture of large cells: large cleaved cells, with irregular nuclei without visible nucleoli; and large non-cleaved cells (centroblasts), having a rounder nucleus with two to three small, peripherally placed nucleoli and a small amount of basophilic cytoplasm.  The follicular variants represent mature B-cell lymphomas, whereas the diffuse variants can be either mature B- or mature T-cell lymphomas.


Acute hemorrhagic edema of infancy

description: A self-limiting cutaneous vasculitis that typically presents as a clinical triad of purpura, edema, and fever in children between the ages of four months and two years old. It is usually associated with a recent history of upper respiratory infection and/or antibiotic therapy.


description: A reactive cutaneous proliferation of macrophages associated with local trauma. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents as a single, asymptomatic, cutaneous or mucosal, firm xanthomatous to dark-red papule or nodule. (WHO 2018)


Low grade myofibroblastic sarcoma

description: A low-grade malignant neoplasm arising from the soft tissue and rarely bone. It is characterized by the presence of spindle-shaped myofibroblasts and collagenous stroma formation in a storiform growth pattern. Metastasis is very rare.


Cutaneous Precursor Lymphoid Neoplasm

description: A precursor lymphoid neoplasm that affects the skin.


Tearing Chest Pain

description: The sensation of chest pain described as a sharp, lacerating, intense, discomfort; sometimes used to describe the pain felt during an aortic dissection.


Stage IIIA Cervical Cancer AJCC v9

description: Stage IIIA includes: T3a, N0, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Adult Erythroleukemia

description: An erythroleukemia occurring in adults.


Grade 1 Ileal Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Lymphangioma of liver

description: A rare lymphangioma that arises from the liver.  It usually occurs in children and adolescents.


Grade 5 Esophagitis, CTCAE

description: Death


Urinary Urgency, CTCAE

description: A disorder characterized by a sudden compelling urge to urinate.


name: Metastatic Childhood Astrocytoma by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage y-II Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor extends beyond kidney but completely resected. Tumor penetrates renal capsule into perirenal fat. Tumor infiltrates the renal sinus and/or invades blood and lymphatic vessels outside renal parenchyma but is completely resected. Tumor infiltrates adjacent organs or vena cava but is completely resected. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 4 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Metastatic sarcoma

description: A sarcoma that has spread from its original site of growth to another anatomic site.


Adverse Event by CTCAE Category

description: An adverse event as categorized by the Common Terminology Criteria for Adverse Events (CTCAE).


Grade 4 Jejunal Perforation, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 5 Liver Dysfunction or Failure by Clinical Classification, CTCAE


name: Grade 4 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Euphoria, CTCAE

description: Mild mood elevation


name: Stage IIIB Ampulla of Vater Cancer AJCC v8

description: Stage IIIB includes: (T4, Any N, M0); (Any T, N2, M0). T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, irrespective of size. N2: Metastasis to four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Acute Vascular Leak Syndrome, CTCAE


name: Grade 1 Associated with Dentures or Dental Prosthesis, CTCAE


Stage IA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring equal or less than 3 mm in depth. (FIGO 2009)


Unresectable Liposarcoma

description: A liposarcoma which is not amenable to surgical resection.


name: Grade 2 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage II Ampulla of Vater Cancer AJCC v7

description: Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the pancreas.  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Teratoma with Endocrine Differentiation

description: A teratoma that arises outside an endocrine organ and shows endocrine differentiation. The endocrine component ranges from benign endocrine tissue to malignant endocrine neoplasms. This category includes struma ovarii, thyroid carcinoma arising in struma ovarii, and carcinoid tumor arising in ovarian teratoma.


Grade 2 Wound Complication, CTCAE

description: Bedside local care indicated


Injury of adrenal gland

description: Trauma to the adrenal gland.


name: Gastrointestinal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures).


name: T-Cell Prolymphocytic Leukemia, Small Cell Variant

description: A T-cell prolymphocytic leukemia characterized by the presence of small neoplastic prolymphocytes often with invisible nucleolus by light microscopy.


Advanced Anal Carcinoma

description: Anal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Myeloproliferative Neoplasm

description: A myeloproliferative neoplasm that does not respond to treatment.


name: IgM-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by expression of IgM and absence of class-switched immunoglobulin heavy chain expression.


Immune Dysregulation Disorder

description: A group of autoimmune disorders characterized by defects in self-tolerance (central or peripheral) resulting in autoimmune disease with or without recurrent infections, comprised by: Familial hemophagocytic lymphohistiocytosis (FHL) syndromes; FHL syndromes with hypopigmentation; Regulatory T cell (Treg) defects (eg, IPEX); Autoimmunity with or without lymphoproliferation (eg, autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy [APECED]); Autoimmune lymphoproliferative syndrome (ALPS); Immune dysregulation with colitis; and Susceptibility to Epstein-Barr virus (EBV) and lymphoproliferative conditions.


name: Grade 3 Neck Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE


Stage III Pancreatic Cancer AJCC v8

description: Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, regardless of size. N2: Metastasis in four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Frontal Lobe Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma occurring in the frontal lobe.


name: Ann Arbor Stage II Supradiaphragmatic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the superior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript.


name: Grade 4 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Hepatic Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 2 Gallbladder Intra-Operative Injury, CTCAE


name: Intraoperative Musculoskeletal Injury, CTCAE

description: A finding of damage to the musculoskeletal system during a surgical procedure.


description: A non-invasive neoplastic process that affects the epithelium of any part of the digestive system.  It is characterized by the presence of morphologic features of dysplasia (e.g., architectural and cytological epithelial alterations) or, in a minority of cases, lack of such morphologic features, as in colonic sessile serrated adenomas/polyps.


name: Prostatic Atypical Adenomatous Hyperplasia

description: A prostatic hyperplasia characterized by the presence of crowded adenomatous epithelial nodules.


Urethral Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures).


Injury of urinary bladder

description: Trauma to the bladder.


name: Grade 4 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Mixed acinar-ductal carcinoma

description: A carcinoma that arises from the pancreas showing either extensive mucin accumulation and acinar neoplastic cells or a mixture of columnar or signet-ring cells and acinar neoplastic cells.


Erythema toxicum neonatorum

description: A benign, self-limited eruption of vesicles, pustules, papules and macules seen in newborns. An eosinophilic infiltrate can be isolated suggesting an immune-mediated reaction in the skin.


name: Grade 2 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gastric Adenoma, Gastric-Type

description: A neoplastic polyp that arises from the stomach.  It is characterized by the presence of gastric epithelial differentiation.  It includes pyloric gland adenomas and foveolar-type adenomas.


Tourettism

description: Tics that are secondary to an identifiable cause.


Periorbital Infection

description: An infectious process affecting the tissues around the orbit.


name: Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Esophageal Varices Hemorrhage, CTCAE


Gallbladder Cancer by AJCC v7 Stage

description: A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 7th edition.


name: Grade 5 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pulmonary Fistula

description: An abnormal communication between the lung and another organ or anatomic site.


Grade 2 Virilization, CTCAE

description: Moderate symptoms; medical intervention indicated


Grade 2 Somnolence, CTCAE

description: Moderate sedation; limiting instrumental ADL


Stage IV Uterine Corpus Cancer AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa). (from AJCC 8th Ed.)


Localized Sarcoma

description: A sarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Grade 3 Biliary Fistula, CTCAE

description: Invasive intervention indicated


name: Grade 4 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


name: Recurrent Human Papillomavirus-Related Malignant Neoplasm

description: The reemergence of human papillomavirus-related malignant neoplasm after a period of remission.


name: Acute Myeloid Leukemia with TBL1XR1-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of TBL1XR1-RARA fusion protein.


name: Stage IIB Gestational Trophoblastic Tumor AJCC v7

description: Stage IIB includes: T2, M0, Risk factors: high risk.  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Drug-induced gingival hyperplasia

description: Overgrowth of the gingival tissue caused by phenytoin, cyclosporine A, and calcium channel blockers.


Grade 5 Penile Infection, CTCAE

description: Death


Stage IB Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma with measured deepest invasion equal or more than 5 mm (greater than Stage IA), lesion limited to the cervix uteri. (FIGO 2018)


Grade 1 Pharyngolaryngeal Pain, CTCAE

description: Mild pain


Hematoma, CTCAE

description: A disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel.


name: Grade 2 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Acute Myocardial Injury with Cardiogenic Shock Related to COVID-19

description: Acute myocardial injury with evidence of cardiogenic shock defined as clinical evidence of low cardiac index (e.g., less than 2.2 L/min/m2) accompanied by impaired tissue perfusion in a patient with probable or confirmed acute COVID-19.


name: Radiating Chest Pain Along Sternal Border

description: The location of the radiating chest pain is along the lateral edge of the sternum.


Recurrent Lymphoma

description: The reemergence of a lymphoma after a period of remission.


Hypokalemia, CTCAE

description: A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood.


name: Grade 2 Pancreatic Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Face Pain, CTCAE

description: Unintended facial pain associated with a medical procedure or administration of a drug.


name: Grade 3 Rectum Stricture or Stenosis, CTCAE


Grade 5 Hypomagnesemia, CTCAE

description: Death


Grade 3 Ileal Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated


name: Stage IV Fallopian Tube Cancer AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes metastasis within the peritoneal cavity). (AJCC 6th and 7th eds.)


Stage IVA Bone Cancer AJCC v7

description: Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Neoplasms, Unknown Primary

description: The spread of a malignant neoplasm from an unknown primary to another region remote from the primary site.


name: Grade 1 Esophageal Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Inguinal hernia, without mention of obstruction or gangrene

description: The protrusion of abdominal cavity contents through the inguinal canal, without mention of obstruction or necrosis of the herniated contents.


name: Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


name: Extragonadal primary germ cell tumor mixed stage III


Polyarticular Still Disease

description: Juvenile rheumatoid arthritis affecting multiple joints, usually symmetrically. It may be associated with low grade fever, anemia, and weight loss. Patients usually test negative for rheumatoid factor.


name: Stage II Contiguous Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ).


Advanced Paraganglioma

description: A paraganglioma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adult Meningioma

description: A meningioma that occurs during adulthood.


Unresectable Pleomorphic Liposarcoma

description: Pleomorphic liposarcoma that is not amenable to surgical resection.


Coronary artery ectasia

description: Diffuse dilation of a coronary artery segment.


Stage IIA2 Cervical Cancer AJCC v7

description: Stage IIA2 includes: T2a2, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Anal Squamous Cell Carcinoma

description: The reemergence of anal squamous cell carcinoma after a period of remission.


name: Grade 2 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Industrial Accident

description: An accident taking place on the site of a commercial enterprise.


name: Stage IIIB Uterine Corpus Cancer AJCC v8

description: Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus carcinoma or carcinosarcoma with vaginal involvement (direct extension or metastasis) or parametrial involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: EBV-Related T/NK-Cell Lymphoproliferative Disorder

description: T/NK-cell lymphoproliferative disorder that is associated with Epstein-Barr virus.


name: Cardiovascular Adverse Events Related to Medications Aimed at COVID-19

description: A cardiovascular adverse event that is attributable to or associated with medications used to treat COVID-19.


Watering Eyes, CTCAE

description: A disorder characterized by excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct.


name: Grade 3 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Dysphagia, CTCAE

description: Severely altered eating/swallowing; tube feeding, TPN, or hospitalization indicated


name: Grade 4 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Pneumonitis and Pulmonary Infiltrates, CTCAE


name: Hodgkin's disease NOS stage II subdiaphragmatic presentation

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the inferior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript.


Osteosarcoma by AJCC v7 Stage

description: A term that refers to the staging of osteosarcoma, following the rules of the TNM AJCC v7 classification system.


Recurrent squamous cell carcinoma

description: A squamous cell carcinoma that has recurred after a period of remission.


Grade 4 Sleep Apnea, CTCAE

description: Cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated


Undifferentiated Malignant Neoplasm

description: A neoplasm that has minimal to no differentiating features.


name: Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Tracheostomy Site Bleeding, CTCAE

description: Death


Grade 1 External Ear Pain, CTCAE

description: Mild pain


Fallopian Tube Serous Neoplasm

description: A benign, borderline, or malignant epithelial tumor of the fallopian tube characterized by the presence of neoplastic serous epithelial cells.


name: Grade 1 Surgical and Medical Procedures - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 2 Anal Stenosis, CTCAE

description: Symptomatic; altered GI function


name: Grade 1 Penis Intra-Operative Injury, CTCAE


name: Advanced Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Chest Pain Along Sternal Border

description: The location of the chest pain is along the lateral edge of the sternum.


Splitting Pain

description: An intense sensation of discomfort or distress that feels like being cut apart.


name: Endometrial Large Cell Neuroendocrine Carcinoma

description: A high grade neuroendocrine carcinoma that arises from the endometrium. It is composed of large polygonal cells arranged in well-demarcated nests, trabeculae or cords with peripheral palisading.


name: Unresectable Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that is not amenable to surgical resection.


Beta-Methylcrotonylglycinuria

description: A very rare metabolic disorder characterized by an inborn error in the leucine degradation pathway. Patients excrete large amounts of beta-methyl-crotonylglycine in the urine.


Grade 5 Rectal Stenosis, CTCAE

description: Death


name: Grade 2 Ventricular Arrhythmia NOS, CTCAE


Acute Myeloid Leukemia with i(17q)

description: Acute myeloid leukemia associated with isochromosome 17q [i(17q)].


Type D Lymphomatoid Papulosis

description: A variant of lymphomatoid papulosis which mimics primary cutaneous aggressive epidermotropic CD8-positive cytotoxic T-cell lymphoma.


name: Monoclonal B-cell lymphocytosis chronic lymphocytic leukemia-type

description: Monoclonal B-cell lymphocytosis characterized by the presence of more than 5 x 10^9/L abnormal B-lymphocytes in peripheral blood and presence of the characteristic immunophenotype of chronic lymphocytic leukemia. This type of monoclonal B-cell lymphocytosis evolves to chronic lymphocytic leukemia at a rate of 1-2% per year.


Benign Vaginal Melanocytic Nevus

description: A neoplasm that arises from the vagina and is characterized by the proliferation of nests of benign melanocytes.


name: Treatment Related Secondary Malignancy, CTCAE

description: A disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy.


Monoblastic Sarcoma

description: A less common form of myeloid sarcoma composed of monoblasts.  Monoblastic sarcoma may precede or occur simultaneously with acute monoblastic leukemia. (WHO 2001)


Grade 5 Prolapse of Urostomy, CTCAE

description: Death


Unresectable Appendix Adenocarcinoma

description: Appendix adenocarcinoma that is not amenable to surgical resection.


name: Grade 3 Cranial Nerve VIII Intra-Operative Injury, CTCAE


name: Paraganglioma-Like Dermal Melanocytic Tumor

description: A benign primary melanocytic tumor of the skin that presents as a dermal nodule. Morphologically, it is characterized by the presence of paraganglioma-like features that include a nested growth pattern of the tumor cells. The nests are composed of epithelioid cells and are separated by delicate fibrous strands. Cytoplasmic melanin is not present; however immunohistochemical studies have confirmed the melanocytic lineage of the tumor cells.


Stage IV Anal Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Grade 4 Infusion Related Reaction, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Peripheral Arterial Ischemia, CTCAE


name: Grade 2 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatitis, CTCAE 5.0

description: A disorder characterized by inflammation of the pancreas with no documented pancreas infection.


name: Grade 4 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Delirium due to a general medical condition

description: A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of a general medical condition.


name: Soft Tissue Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


name: Cervical Squamous Cell Carcinoma In Situ

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Granular Cell Glioblastoma

description: A glioblastoma characterized by the presence of large numbers of neoplastic cells with granular, PAS-positive cytoplasm. It is associated with an aggressive clinical course.


name: Grade 4 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE


Umbilical granuloma

description: Excessive granulation tissue at the base of the umbilicus after separation.


Grade 4 Vaginal Inflammation, CTCAE

description: Life-threatening consequences; widespread areas of mucosal ulceration; urgent intervention indicated


name: Grade 3 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Refractory Small Cell Neuroendocrine Carcinoma

description: Small cell neuroendocrine carcinoma that is resistant to treatment.


name: Grade 5 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Erythema Multiforme, CTCAE

description: Target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated


name: Grade 2 Carotid Artery Intra-Operative Injury, CTCAE


Grade 2 Hyperhidrosis, CTCAE

description: Involving >1 site; patient seeks medical intervention; associated with psychosocial impact


name: Grade 3 Salivary Gland Intra-Operative Injury, CTCAE


name: Grade 1 Vaginitis Not Due to Infection, CTCAE


Grade 1 Lymphocele, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Blurred Vision, CTCAE

description: Intervention not indicated


name: Grade 2 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


description: An uncommon variant of rhabdomyosarcoma with spindle cell or sclerosing morphology.  It affects both children and adults and it is more common in males.


Grade 5 Delirium, CTCAE

description: Death


name: Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Bladder Stricture or Stenosis, CTCAE


Small Lymphocytic Lymphoma Variant

description: A term referring to cases of small lymphocytic lymphomas with an increased number of paraimmunoblasts or with signet-ring-like lymphocytes.


Grade 2 Lactation Disorder, CTCAE

description: Changes in lactation, significantly affecting breast production or expression of breast milk


Grade 1 Hyponatremia, CTCAE

description: <LLN-130 mmol/L


name: Grade 4 Intraoperative Reproductive Tract Injury, CTCAE


name: Grade 3 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Grade 3 Eosinophilia, CTCAE

description: Steroids initiated


name: Grade 5 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Hodgkin's disease lymphocyte predominance type refractory

description: An antiquated term that refers either to nodular lymphocyte predominant Hodgkin lymphoma or to lymphocyte-rich classical Hodgkin lymphoma that is resistant to treatment.


Grade 2 Voice Alteration, CTCAE

description: Moderate or persistent change from normal voice; still understandable


name: Local Complication of Device and Prosthesis, CTCAE


name: Acinar Cystic Transformation of the Pancreas

description: A non-neoplastic cystic lesion of the pancreas lined by benign-appearing acinar and ductal epithelium. (WHO 2019)


Cocaine dependence, episodic

description: Physical and psychological dependence on the drug cocaine, which is associated with a pattern of episodic use.


Nerve palsy

description: Paralysis that is caused by damage to a nerve.


Flatulence, CTCAE

description: A disorder characterized by a discharge of excessive gas from the lower GI tract.


Stage IIIC Cutaneous Melanoma AJCC v7

description: Stage IIIC includes: (T1-4b, N1b, M0); (T1-4b, N2b, M0); (T1-4b, N2c, M0); (Any T, N3, M0).  T1-4b: Ulcerated cutaneous melanoma of any thickness.  N1b: Cutaneous melanoma with macrometastasis in one regional lymph node.  N2b: Cutaneous melanoma with macrometastases in 2-3 regional lymph nodes.  N2c: Cutaneous melanoma with intralymphatic metastases (in transit or satellite metastases) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Disseminated Malignant Neoplasm

description: Cancer that is spread throughout the body, a metastatic phenomenon.


Non-Neoplastic Esophageal Disorder

description: A non-neoplastic disorder that affects the esophagus. Representative examples include infections, ulcers, and gastroesophageal reflux disease.


name: Grade 1 Metabolic or Respiratory Alkalosis, CTCAE


Endophthalmitis, CTCAE

description: A disorder characterized by an infectious process involving the internal structures of the eye.


name: Grade 2 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage I Fallopian Tube Cancer

description: Stage I includes: (T1, N0, M0); IA (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to the fallopian tube(s).  T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  T1b: Tumor limited to both tubes, without penetrating the serosal surface; no ascites.  T1c: Tumor limited to one or both tubes with extension onto or through the tubal serosa, or with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Invasive Ureter Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma of the ureter that exhibits squamous differentiation.


Childhood Pigmented Spindle Cell Nevus

description: A pigmented spindle cell nevus that occurs during childhood.


name: Stage II Appendix Neuroendocrine Tumor AJCC v8

description: Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Belching, CTCAE

description: Intervention initiated (including over the counter medications)


name: Large cell calcifying Sertoli cell tumor

description: A testicular Sertoli cell tumor characterized by the presence of large polygonal cells with eosinophilic cytoplasm in a myxoid and hyalinized stroma. Calcifications may be present in the stroma. Malignant behavior is uncommon.


name: Grade 5 Edema of the Trunk and Genital Area, CTCAE


name: Grade 3 Pharyngeal Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Congenital Bleeding Disorder

description: A bleeding disorder that is diagnosed during childhood, with the presenting symptom of excessive bleeding.


name: Grade 1 Urinary Conduit Intra-Operative Injury, CTCAE


Bladder Anastomotic Leak, CTCAE

description: A finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures).


name: Grade 5 Stenosis of Gastrointestinal Stoma, CTCAE

description: Death


name: Grade 4 Fallopian Tube Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Other and Unspecified Infectious and Parasitic Diseases and their Sequelae

description: Unspecified infectious and parasitic diseases and their sequelae other than those otherwise specified.


name: Acute Myocardial Injury with Myocarditis Related to COVID-19

description: Acute myocardial injury with clinical, imaging, and or pathology evidence supporting myocarditis in a patient with probable or confirmed acute COVID-19.


Grade 2 Eye Infection, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Current Cytomegalovirus Infection

description: Cytomegalovirus infection is evident at the time of testing.


Grade 2 Lymph Gland Infection, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage IV Cervical Cancer AJCC v9

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


Aortic Injury, CTCAE

description: A finding of damage to the aorta.


Grade 3 Vaccination Complication, CTCAE

description: Severe pain; Erythema > 10 cm; Induration/swelling > 10 cm; necrosis; limiting self care ADL


Low Grade Liver Dysplastic Nodule

description: A hepatic dysplastic nodule characterized by the presence of low grade atypical cellular changes.


Advanced Carcinoma Of Unknown Primary

description: A carcinoma of unknown primary that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 4 Injury To Inferior Vena Cava, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Left Ventricular Systolic Dysfunction, CTCAE 5.0

description: A disorder characterized by failure of the left ventricle to produce adequate output.


Retroperitoneal Hemorrhage, CTCAE 5.0

description: A disorder characterized by bleeding from the retroperitoneal area.


name: Recurrent Primary Malignant Central Nervous System Neoplasm

description: The reemergence of a primary malignant central nervous system neoplasm after a period of remission.


name: Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Postpartum Uterine Inversion

description: Protrusion of the uterine fundus through the cervix when the placenta fails to detach from the uterus as it exits.


Grade 5 Sudden Death NOS, CTCAE

description: Death


Grade 5 Cardiac Arrest, CTCAE

description: Death


Grade 3 Hypoglycemia, CTCAE

description: <40-30 mg/dL; <2.2-1.7 mmol/L


name: Grade 3 Hepatic Artery Intra-Operative Injury, CTCAE


name: Grade 3 Peritoneal Cavity Hemorrhage, CTCAE


name: Human Papillomavirus-Independent Cervical Adenocarcinoma

description: Cervical adenocarcinoma not associated with human papillomavirus infection.


name: Upper Extremity Intra-Operative Injury, CTCAE


Grade 2 Keratitis, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


name: Cranial Nerve II Intra-Operative Injury, CTCAE


Grade 3 Infant Irritability, AE

description: An adverse event in a newborn characterized by severe irritability, major changes in feeding behavior, requiring support other than oral feeding; requiring long term medical treatment (e.g. sedatives).


Grade 4 Esophageal Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Blood Corticotrophin Decreased, CTCAE

description: A finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen.


name: Grade 2 Cranial Nerve I Intra-Operative Injury, CTCAE


Advanced Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


name: Grade 5 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 1 Uterine Pain, CTCAE

description: Mild pain


name: Grade 3 Fibrosis-Deep Connective Tissue, CTCAE


Grade 4 Urostomy Obstruction, CTCAE

description: Life-threatening consequences; organ failure; urgent operative intervention indicated


name: Grade 1 Prostate Stricture or Stenosis, CTCAE


Stage IIIB Cutaneous Melanoma AJCC v7

description: Stage IIIB includes: (T1-4b, N1a, M0); (T1-4b, N2a, M0); (T1-4a, N1b, M0); (T1-4a, N2b, M0); (T1-4a, N2c, M0).  T1-4b: Ulcerated cutaneous melanoma of any thickness.  T1-4a: Non-ulcerated cutaneous melanoma of any thickness.  N1a: Cutaneous melanoma with micrometastasis in one regional lymph node.  N2a: Cutaneous melanoma with micrometastases in 2-3 regional lymph nodes.  N1b: Cutaneous melanoma with macrometastasis in one regional lymph node.  N2b: Cutaneous melanoma with macrometastases in 2-3 regional lymph nodes.  N2c: Cutaneous melanoma with intralymphatic metastases (in transit or satellite metastases) without metastatic nodes.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Cervical Squamous Neoplasm

description: A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the cervix. Representative examples include condyloma acuminatum, cervical intraepithelial neoplasia, and squamous cell carcinoma.


name: large cell neuroendocrine carcinoma of bladder

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the bladder.  It is characterized by the presence of malignant large cells.


name: Unresectable Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that is not amenable to surgical resection.


Grade 5 Phlebitis Infective, CTCAE

description: Death


name: High Grade Prostatic Intraepithelial Neoplasia, Signet Ring Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of signet ring cells in the affected glands.


Focal acute inflammation

description: An inflammatory process characterized by the localized collection of polymorphonuclear neutrophils.


name: Grade 2 Upper Gastrointestinal Hemorrhage NOS, CTCAE


name: Grade 3 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Aorta Artery Intra-Operative Injury, CTCAE


name: Childhood Acute Lymphoblastic Leukemia CNS 3 Toronto Guidelines v2

description: Clinical signs of CNS involvement or blasts in CSF and WBC > or = 5/uL CSF and either: RBC < 10/uL CSF or RBC > or = 10/uL CSF and WBC/RBC in CSF > 2x WBC/RBC in blood. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Pancreatoblastoma

description: A pancreatoblastoma that occurs during childhood. It is the most common malignant pancreatic  neoplasm in children younger than ten years of age.


name: Grade 2 Bone Growth Limb Length Discrepancy, CTCAE


name: Grade 3 Spine Kyphosis or Lordosis, CTCAE


name: Grade 4 Other Constitutional Symptoms, CTCAE


name: Grade 3 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Hepatic Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the liver region.


Recurrent Childhood Kidney Neoplasm

description: The reemergence of renal neoplasm in childhood after a period of remission.


Grade 5 Meningitis, CTCAE

description: Death


Grade 3 Neonatal Constipation, AE

description: An adverse event in a newborn characterized by reduced number of stools or hard stools; signs of obstruction; apparent discomfort or affecting feeding; major care changes indicated (e.g. long term medical treatment, enema).


name: FIGO Stage IB Gestational Trophoblastic Tumor


Recurrent Aggressive NK-Cell Leukemia

description: The reemergence of aggressive NK-cell leukemia after a period of remission.


name: Grade 4 Psychiatric Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; hospitalization or urgent intervention indicated


name: Grade 4 Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


Benign neoplasm of pineal gland

description: A neoplasm that arises from the pineal region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 1 Restrictive Cardiomyopathy, CTCAE

description: Imaging findings only


Grade 3 Flushing, CTCAE

description: Symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL


name: Supraventricular and Nodal Arrhythmia, CTCAE


name: Grade 2 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Verrucous carcinoma of the oral cavity stage 0


name: Grade 4 Neonatal Gastrointestinal Bleeding, AE

description: A gastrointestinal bleeding adverse event in a newborn characterized by life-threatening consequences (e.g. hemorrhagic shock); urgent major care change required.


Grade 5 Eye Infection, CTCAE

description: Death


name: Hematologic Neoplasm with Germline DDX41 Mutation

description: An autosomal dominant familial myelodysplastic syndrome/acute myeloid leukemia syndrome characterized by inherited mutations in the gene on chromosome 5 encoding the DEAD box RNA helicase DDX41. Patients usually present with leukopenia, hypocellular bone marrow with prominent erythroid dysplasia and a normal karyotype, often leading to erythroleukemia. The prognosis is generally poor. (WHO 2017)


Unresectable Glioma

description: A glioma that is not amenable to surgical resection.


name: Grade 1 Lip Or Perioral Area Intra-Operative Injury, CTCAE


carcinoma of epididymis

description: A rare carcinoma that arises from the epididymis.


Visual Pathway Neoplasm

description: A neoplasm that affects the visual pathway.


name: Grade 5 Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Polyclonal Polymorphic Post-Transplant Lymphoproliferative Disorder


name: Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


name: Blood Antidiuretic Hormone Abnormal, CTCAE

description: A finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen.


Recurrent Primary Bone Lymphoma

description: The reemergence of primary lymphoma of bone after a period of remission.


Metastatic Appendix Carcinoma

description: Carcinoma of the appendix that has spread from the original site of growth to other anatomic sites.


name: Grade 3 Abdomen Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Lethargy, CTCAE

description: A disorder characterized by a decrease in consciousness characterized by mental and physical inertness.


AIDS-Related Anal Carcinoma

description: A carcinoma arising from the anus and occurring in HIV-positive patients. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Sexually transmitted human papillomavirus is detected in the majority of the cases.


Schwannoma of the Seventh Cranial Nerve

description: A benign, usually encapsulated slow growing tumor composed of Schwann cells affecting the seventh cranial nerve.


name: Grade 3 Urethral Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 5 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Locally Advanced Bladder Carcinoma

description: A bladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Congenital Hand and Foot Deformity

description: A malformation in the hand or foot that is present at birth. Representative examples include syndactyly, polydactyly, brachydactyly, and thumb hypoplasia.


Grade 3 Neonatal Edema, AE

description: An adverse event in a newborn characterized by severe edema; limiting age appropriate behavior; requiring major care changes (e.g. diuretics).


Grade 1 Anemia, CTCAE

description: Hemoglobin (Hgb) <LLN-10.0 g/dL; <LLN-6.2 mmol/L; <LLN-100 g/L


Chronic esophagitis

description: A chronic inflammatory process affecting the esophageal wall.


name: Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Vaginal Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Low Grade Lung Neuroendocrine Neoplasm

description: A low grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes typical carcinoid tumor.


name: Chest Pain in Left Second Intercostal Space

description: The location of the chest pain is within the second intercostal space on the left side.


Grade 1 Gastrointestinal Pain, CTCAE

description: Mild pain


name: Grade 4 Brain Intra-Operative Injury, CTCAE


name: Adult Diffuse Small Cleaved Cell Lymphoma

description: An antiquated term for a diffuse B-or T-cell lymphoma composed of small cleaved lymphocytes, occurring in adults.


Grade 1 Ankle Fracture, CTCAE

description: Mild; non-operative intervention indicated


name: Grade 3 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Burn, CTCAE

description: Death


name: Grade 5 Other Hepatobiliary and Pancreas, CTCAE


name: Recurrent T-Cell Large Granular Lymphocyte Leukemia

description: The reemergence of T-cell large granular lymphocyte leukemia after a period of remission.


Mixed acidophil-basophil carcinoma

description: A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic and basic dyes.


name: Grade 5 Cranial Nerve VIII Neuropathy, CTCAE


name: Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8

description: Stage II includes: T3, N0, M0. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Oral Dysesthesia, CTCAE

description: A disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth.


name: Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted

description: An oligodendroglioma carrying IDH gene family mutation and combined whole-arm losses of 1p and 19q (1p/19q codeletion).


name: Grade 3 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Tissue Breakdown

description: A process caused by injury or disease or aging and characterized by a partial/complete disruption of tissue. The disruption may be temporary or permanent and may be associated with either (1) impairment or (2) loss of function of the affected organ(s) or system(s).


name: Locally Advanced Squamous Cell Carcinoma of Unknown Primary

description: A squamous cell carcinoma of unknown primary that has spread from its original site of growth to nearby tissues or lymph nodes.


Hypoxic Ischemic Encephalopathy, AE

description: An adverse event in a newborn characterized by injury to the central nervous system that occurs when there is insufficient delivery of oxygen to all or part of the brain.


name: Adverse Event Associated with Surgery and Intra-Operative Injury

description: An adverse event associated with surgery or an intra-operative injury.


name: Outer Hair Sheath and Infundibulum Neoplasm

description: A neoplasm involving the outer hair sheath and infundibulum.


name: Grade 3 Soft Tissue NOS Intra-Operative Injury, CTCAE


Laryngeal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the laryngeal airway.


Magnocellular nevus

description: A benign neoplastic melanocytic proliferation within or adjacent to the optic disk. It presents as a pigmented, intraocular tumor.


name: Pediatric and/or Germline Mutation-Associated Myeloid Disorders

description: A group of myeloid disorders that occur in childhood and/or are associated with germline gene mutations. It includes juvenile myelomonocytic leukemia, juvenile myelomonocytic leukemia-like neoplasm, refractory cytopenia of childhood, Noonan syndrome-associated myeloproliferative disorder, and myeloid neoplasm with germline predisposition.


name: Folate deficiency anemia due to dietary causes

description: Anemia caused by folate deficiency due to insufficient dietary intake.


name: Grade 3 Local Complication of Device and Prosthesis, CTCAE


Grade 3 Bladder Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Stage IVB Bone Sarcoma AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Central Nervous System Hemangioblastoma

description: A rare, slow-growing, WHO grade I tumor of uncertain histogenesis that arises from the central nervous system. It is composed of stromal cells and abundant capillaries. It can occur sporadically or as part of von Hippel- Lindau syndrome.


Juxtaglomerular tumor

description: A benign, well circumscribed neoplasm arising from the cortex of the kidney. It secrets renin and the patients usually present with severe hypertension and marked hypokalemia. Morphologically, it is characterized by the presence of sheets of polygonal or spindle-shaped neoplastic cells forming a hemangiopericytic pattern.


name: Grade 2 Spermatic Cord Stricture or Stenosis, CTCAE


name: Grade 4 Peripheral Sensory Neuropathy, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 5 Anal Stenosis, CTCAE

description: Death


Grade 3 Hypothyroidism, CTCAE

description: Severe symptoms; limiting self care ADL; hospitalization indicated


name: Grade 3 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Biliary Fistula, CTCAE

description: Death


name: Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIB includes: T2, N0, M0. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Stroke, CTCAE

description: Mild to moderate neurologic deficit; limiting instrumental ADL


Giant Fibrovascular Esophageal Polyp

description: A benign, elongated intraluminal polypoid neoplasm of the esophagus.  It is characterized by the presence of adipose tissue lobules separated by dense fibrous tissue bands and dilated blood vessels.  The polyp is covered by normal squamous epithelium.


name: Grade 3 Neonatal Gastrointestinal Bleeding, AE

description: A gastrointestinal bleeding adverse event in a newborn characterized by severe bleeding; non-life threatening hemodynamic consequences; major care change required (e.g. invasive intervention, transfusion, long term medical treatment).


Liver Congenital Hemangioma

description: A hemangioma that arises from the liver and is present at birth. The majority involute in infancy.


name: Grade 4 Vas Deferens Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Persistent Hyaloid Vessels

description: A congenital abnormality of the eye caused by failure of regression of the fetal eye vasculature.


Spasticity, CTCAE

description: A disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances.


name: Metastatic Non-Muscle Invasive Bladder Carcinoma

description: Non-muscle invasive bladder carcinoma that has spread from its original site of growth to another anatomic site.


name: Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Transport Injury

description: An injury to an individual during transport between or to/from departments or facilities.


name: Gastric Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach.  It is characterized by the presence of malignant large cells.


name: Invasive Urothelial Carcinoma with Glandular Differentiation

description: An invasive urothelial carcinoma that exhibits glandular differentiation.


name: large cell neuroendocrine carcinoma of gallbladder

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder.  It is characterized by the presence of malignant large cells.


Localized Malignant Pancreatic Neoplasm

description: A malignant neoplasm that arises from the pancreas and has not spread to other anatomic sites.


name: Gallbladder Adenocarcinoma, Gastric Foveolar Type

description: An unusual, well differentiated adenocarcinoma that arises from the gallbladder.  It is characterized by the presence of tall malignant columnar cells with mucin-containing cytoplasm and basally located nuclei.


name: Non-T Non-B CALLA Negative Childhood Acute Lymphoblastic Leukemia

description: Non-T non-B, CALLA negative acute lymphoblastic leukemia that occurs during childhood.


Grade 3 Anemia, CTCAE

description: Hgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated


name: Superior Vena Cava Intra-Operative Injury, CTCAE


Grade 5 Uterine Perforation, CTCAE

description: Death


Grade 1 Breast Pain, CTCAE

description: Mild pain


name: Metastatic Appendix Mucinous Adenocarcinoma

description: Mucinous adenocarcinoma of the appendix that has spread from the original site of growth to other anatomic sites.


Grade 3 Lymphedema, CTCAE

description: Severe symptoms; limiting self care ADL


Pedestrian Injury By Road Vehicle

description: An injury to a pedestrian sustained by a vehicle that travels on the road.


name: Stage IB Ampulla of Vater Cancer AJCC v8

description: Stage IB includes: (T1b, N0, M0); (T2, N0, M0). T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Paroxysmal Atrial Tachycardia, CTCAE

description: Life-threatening consequences; incompletely controlled medically; cardioversion indicated


name: Functional disorder of polymorphonuclear neutrophil

description: A disorder caused by a dysfunction of polymorphonuclear neutrophils (PMNs).


name: Grade 1 Small Bowel NOS Intra-Operative Injury, CTCAE


name: Grade 1 Pancreatic Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Lethargy, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Closed traumatic dislocation of glenohumeral joint

description: A closed dislocation of the shoulder


Stage 0 Appendix Carcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (intramucosal carcinoma; invasion of the lamina propria or extension into but not through the muscularis mucosae). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Gastrointestinal Stoma Necrosis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Refractory Ureter Urothelial Carcinoma

description: Ureter urothelial carcinoma that is resistant to treatment.


Stage IA Cervical Cancer AJCC v9

description: Stage IA includes: T1a, N0, M0. T1a: Tumor that can be diagnosed only by microscopy with maximum depth of invasion equal or less than 5 mm. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IB Vulvar Cancer AJCC v7

description: Stage IB includes: T1b, N0, M0.  T1b: Vulvar cancer with tumor size greater than 2 cm, or any size with stromal invasion more than 1.0 mm, confined to the vulva or perineum.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Kappa Light Chain-Restriction

description: An increase in the ratio of cells expressing the immunoglobulin light chain (Ig LC) kappa versus those expressing Ig LC lambda in a sample.


name: Neoplastic Post-Transplant Lymphoproliferative Disorder

description: A lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy.  It is characterized by the presence of tissue destruction and effacement of the architecture of the involved tissues. It includes the following variants: polymorphic, monomorphic, and classical Hodgkin lymphoma post-transplant lymphoproliferative disorders.


name: Recurrent T/NK-Cell Lymphoproliferative Disorder

description: The reemergence of T/NK-cell lymphoproliferative disorder after a period of remission.


name: Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage 0 Vaginal Cancer AJCC v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma). N0: No regional lymph node metastasis.  M0: No distant metastasis.  FIGO no longer includes stage 0. (AJCC 7th ed.)


Grade 1 Meningismus, CTCAE

description: Mild symptoms


Stage IIA2 Cervical Cancer AJCC v9

description: Stage IIA2 includes: T2a2, N0, M0. T2a2: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Grade 2 Atrioventricular Block First Degree, CTCAE

description: Non-urgent intervention indicated


Grade 4 Urinary Retention, CTCAE

description: Life-threatening consequences; organ failure; urgent operative intervention indicated


Grade 1 Hydrocephalus, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage I Prostate Cancer AJCC v7

description: Stage I includes: (T1a-c, N0, M0, PSA less than 10, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 10, Gleason equal or less than 6); (T1-2a, N0, M0, PSA X, Gleason X).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less. cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason X: Gleason score cannot be processed.  (AJCC 7th ed.)


name: Grade 3 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Mediastinum Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Appendix Carcinoma AJCC v8

description: Stage IV includes: IVA: (Any T, N0, M1a); (Any T, Any N, M1b, G1); IVB: (Any T, Any N, M1b, G2, G3, or GX); IVC: (Any T, Any N, M1c, Any G). N0: No regional lymph node metastasis. M1a: Intraperitoneal acellular mucin, without identifiable tumor cells in the disseminated peritoneal mucinous deposits. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. M1c: Metastasis to sites other than peritoneum. G1: Well differentiated. G2: Moderately differentiated. G3: Poorly differentiated. GX: Grade cannot be assessed. (AJCC 8th ed.)


name: Grade 1 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Uterine Cervix Cyst

description: A cyst in the uterine cervix.


name: Grade 4 Vulva Intra-Operative Injury, CTCAE


name: Grade 4 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Superior Vena Cava Intra-Operative Injury, CTCAE


Hallucinogen dependence, continuous

description: Physical and psychological dependence on hallucinogenics, which is associated with a pattern of continuous use.


Grade 2 Sinus Disorder, CTCAE

description: Symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL


Regressing Non-Cutaneous Melanoma

description: The disappearance of the melanoma cells from the primary non-cutaneous melanoma site.


name: IgM monoclonal gammopathy of uncertain significance

description: Monoclonal gammopathy of undetermined significance defined by a serum IgM paraprotein concentration less than 30g/L; bone marrow lymphoplasmacytic infiltration of less than 10%; and no evidence of anemia, constitutional symptoms, hyperviscocity, lymphadenopathy, hepatosplenomegaly, or other end-organ damage that can be attributed to the underlying lymphoproliferative disorder. It is a precursor condition that may progress to lymphoplasmacytic lymphoma/ Waldenstrom macroglobulinemia, other B-cell neoplasms, or primary amyloidosis. Progression to plasma cell myeloma occurs rarely, if at all. (WHO 2017)


name: Stage IIIB Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIIB includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis.  (AJCC 7th ed.)


name: Grade 5 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Lipase Increased, CTCAE

description: >ULN-1.5 x ULN


Childhood Benign Breast Neoplasm

description: A childhood neoplasm that arises from the breast and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 1 Gastric Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Grade 3 Vaginal Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Secondary Central Nervous System Lymphoma

description: A non-Hodgkin or Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


name: Grade 5 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant gastrinoma of pancreas

description: A gastrin-producing neuroendocrine tumor arising from the pancreas.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


Benign nipple neoplasm

description: A neoplasm that arises from the nipple and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 4 Rectal Varices Hemorrhage, CTCAE


Grade 5 Acute Kidney Injury, CTCAE

description: Death


Intermediate Chondrogenic Neoplasm

description: A locally aggressive or rarely metastasizing cartilaginous matrix-producing neoplasm characterized by the presence of neoplastic chondrocytes.


Liver Teratoma

description: A teratoma that arises from the liver.


Non-Organic Failure to Thrive

description: Failure to thrive caused by inadequate intake due to environmental influences, stimulus deprivation- poverty, feeding techniques, or psychological reason, and without any apparent growth-inhibiting organic disorder.


Grade 1 Tooth Discoloration, CTCAE

description: Surface stains


name: Grade 2 Biliary Tree Stricture or Stenosis, CTCAE


name: Adverse Event Associated with Allergy and Immunology


name: Human Papillomavirus-Related Urethral Squamous Cell Carcinoma

description: A rare urethral squamous cell carcinoma that is related to human papilloma virus (HPV) infection of the urinary tract.


name: Grade 1 Spinal Cord Intra-Operative Injury, CTCAE


name: Papillary mucinous cystadenoma, borderline malignancy

description: A low malignant potential cystic epithelial neoplasm usually arising from the ovary. It is composed of glandular cells with intracytoplasmic mucin. It is characterized by an atypical epithelial proliferation and a papillary growth pattern. There is no evidence of destructive stromal invasion.


Locally Advanced Glioblastoma

description: Glioblastoma that has spread from its original site of growth to nearby tissues.


Stage IIA Bone Cancer AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Stage IIA Nasopharyngeal Keratinizing Squamous Cell Carcinoma


name: Grade 4 Cranial Nerve XII Intra-Operative Injury, CTCAE


name: Acute Myeloid Leukemia with t(11;17)(q13;q21); NUMA1-RARA

description: Acute myeloid leukemia with the variant RARA t(11;17)(q13;q21) and the expression of NUMA1-RARA fusion protein.


name: Grade 4 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Childhood Carcinoma

description: A rare carcinoma that occurs during childhood.


Grade 2 Premature Delivery, CTCAE

description: Delivery of a liveborn infant at >28 to 34 weeks gestation


familial meningioma

description: A meningioma that is transmitted from the parents to an offspring.


name: Grade 1 Vascular Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Stage III Low-CSD Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Acute on chronic right heart failure

description: Acute decompensation of chronic right heart failure.


name: Grade 5 Other Growth and Development, CTCAE


name: Adult Respiratory Distress Syndrome, CTCAE

description: A disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery.


name: Grade 5 Thrombotic Thrombocytopenic Purpura, CTCAE

description: Death


Erythema multiforme minor

description: Self-limiting form of erythema multiforme.


name: Unresectable Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that is not amenable to surgical resection.


Grade 3 Biliary Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Grade 4 Budd-Chiari Syndrome, CTCAE

description: Life-threatening consequences; moderate to severe encephalopathy; coma


Locally Advanced Fibrosarcoma

description: Fibrosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 3 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Small Intestinal Mucositis, CTCAE

description: Severe pain; interfering with oral intake; tube feeding, TPN or hospitalization indicated; limiting self care ADL


Edema of foot (finding)

description: The accumulation of fluid in the feet, most prominently on the dorsum.


Guillain-Barre Syndrome, CTCAE

description: A disorder characterized by the body's immune system attacking the peripheral nervous system causing ascending paralysis.


Morbidly adherent placenta (disorder)

description: A condition in which the placenta implants abnormally into the uterine myometrium, rather than implanting into the uterine decidua basalis as is normal.


Stage IVB Bone Cancer AJCC v8

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N1: Regional lymph node metastasis. M1b: Metastasis in the bone or other distant sites. (AJCC 8th ed.)


description: A psychological or behavioral condition that existed previously and is genetic in nature.


Hypoglossal Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the hypoglossal nerve (twelfth cranial nerve).


name: Respiratory, thoracic and mediastinal disorders

description: A non-neoplastic or neoplastic disorder that affects the respiratory system or the thoracic organs.


clear cell type neoplasm

description: A malignant neoplasm characterized by the presence of atypical cells with clear cytoplasm.


name: Grade 4 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Dysmenorrhea, CTCAE

description: A disorder characterized by abnormally painful abdominal cramps during menses.


Grade 5 Uterine Fistula, CTCAE

description: Death


Grade 2 Arterial Injury, CTCAE

description: Symptomatic; repair or revision not indicated


Grade 3 Uterine Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 3 Neutrophil Count Decreased, CTCAE

description: <1000-500/mm3; <1.0-0.5 x 10e9/L


Grade 5 Arterial Thromboembolism, CTCAE

description: Death


name: Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Increased Uric Acid Level

description: A laboratory test result indicating abnormally high concentration of uric acid in the blood.


Stage IIA1 Cervical Cancer AJCC v7

description: Stage IIA1 includes: T2a1, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Spindle cell melanoma, type A

description: A melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. Representative example is the type A spindle cell uveal melanoma.


name: Stage II Esophageal Adenocarcinoma AJCC v7

description: Stage II includes: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis. G3: Poorly differentiated.  (AJCC 7th ed.)


name: Grade 5 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Esophageal Adenocarcinoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Anogenital papillomaviral intraepithelial neoplasia


Sinusoidal Obstruction Syndrome, CTCAE

description: A disorder characterized by severe hepatic injury as a result of the blood vessels of the liver becoming inflamed and/or blocked.


Ovarian Rupture

description: Tearing or disruption of the ovarian tissue.


name: Grade 2 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gastric Juvenile Polyp

description: A non-neoplastic polyp that arises from the stomach and is characterized by the presence of elongated, tortuous, and cystic foveolar zones, edematous changes, and inflammation.  It may be associated with juvenile polyposis in other parts of the gastrointestinal tract.


Bone Langerhans Cell Histiocytosis

description: Langerhans cell histiocytosis affecting the bone.


name: Grade 4 Genitourinary Stoma Hemorrhage, CTCAE


Palpitations, CTCAE

description: A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart.


name: Low Grade Conjunctival Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the conjunctival epithelium.


Rhinitis Infective, CTCAE

description: A disorder characterized by an infectious process involving the nasal mucosal.


name: Grade 3 Retina Intra-Operative Injury, CTCAE


name: Grade 5 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Metastatic Midgut Neuroendocrine Tumor G3

description: A midgut neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


Grade 5 Bronchial Stricture, CTCAE

description: Death


Grade 4 Malabsorption, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Musculoskeletal Chest Pain due to Epidemic Myalgia

description: A condition in which there is myositis secondary to an infectious etiology. (ACC/AHA)


Recurrent AL Amyloidosis

description: The reemergence of AL amyloidosis after a period of remission.


name: Serous cystadenoma, borderline malignancy

description: A serous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells with an absence of stromal invasion.


Critical illness polyneuromyopathy

description: Polyneuropathy and myopathy arising in intensive care unit patients.


name: Ann Arbor Stage II Subdiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


name: Grade 4 Outer Ear Pinna Intra-Operative Injury, CTCAE


Grade 3 Vaginal Fistula, CTCAE

description: Invasive intervention indicated


Bruising, CTCAE

description: A finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues.


Grade 5 Skin Induration, CTCAE

description: Death


name: Gastroesophageal Junction Adenocarcinoma by AJCC v8 Stage

description: A term that refers to the staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Grade 4 Neonatal Hypertension, AE

description: A hypertensive adverse event in a newborn characterized by life-threatening consequences (e.g. malignant hypertension: shock, cardiac failure or neonatal encephalopathy).


name: Lugano Classification Stage I Adult Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Grade 4 Intraoperative Head and Neck Injury, CTCAE


Urinary straining

description: The need to increase intra-abdominal pressure in order to initiate and maintain voiding.


name: Grade 1 Slipped Capital Femoral Epiphysis, CTCAE


Somatostatinoma, malignant

description: A neuroendocrine tumor arising from delta cells which produce somatostatin. It displays vascular invasion and metastasizes to other anatomic sites.


name: Grade 3 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Neoplasms, Radiation-Induced

description: A neoplasm that develops as a result of exposure to radiation.


Respiratory Failure, CTCAE

description: A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide.


name: Grade 3 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: COVID-19-Associated Acute Hemorrhagic Necrotizing Encephalitis

description: Acute hemorrhagic necrotizing encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Grade 2 Pulmonary Fibrosis Radiographic Changes, CTCAE


Grade 4 Kidney Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 3 Urostomy Stenosis, CTCAE

description: Symptomatic (e.g., hydronephrosis, or renal dysfunction); elective operative intervention indicated


name: Stage IIIA Fallopian Tube Cancer AJCC v8

description: Stage IIIA includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Micropapillary urothelial carcinoma

description: A transitional cell carcinoma characterized by a micropapillary growth pattern. Typical example is the micropapillary variant of infiltrating bladder urothelial carcinoma.


name: Grade 1 Small Bowel Stricture or Stenosis NOS, CTCAE


Serious Adverse Experience

description: A situation referring to a severe reaction, risk or indication against use of a treatment or device.


name: Grade 3 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Bone Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Glioneuroma of ciliary body

description: A congenital choristoma in the ciliary body. It consists of a mass of mature glial and neuronal cells without neoplastic potential in an otherwise healthy child; there is usually an adjacent coloboma of the anterior uvea and retina. (WHO 2018)


name: Grade 4 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Vaginal Dryness, CTCAE

description: Moderate vaginal dryness interfering with sexual function or causing frequent discomfort


Cerebral Adrenoleukodystrophy

description: A subtype of adrenoleukodystrophy (ALD) occurring in approximately 40 percent of boys with ALD, primarily affecting the cerebrum, resulting in rapidly declining neurocognitive function and in most patients, premature death.


Clinical Chemistry Finding

description: The results of any chemical or enzymatic analyses of body fluids and tissues of an organism.


Refractory Ocular Melanoma

description: Ocular melanoma that is resistant to treatment.


name: Increased Time To Concomitant Drug Peak Blood Concentration

description: Increased time following concomitant drug administration at which the peak drug blood concentration occurs.


Castration-Naive Prostate Carcinoma

description: Advanced prostatic carcinoma which was not previously treated with androgen-deprivation therapy.


name: Grade 4 Cranial Nerve XI Neuropathy, CTCAE


name: Grade 2 Ophthalmoplegia and Diplopia, CTCAE


name: Grade 1 Rectal Varices Hemorrhage, CTCAE


Withdrawal (dysfunction)

description: A social or emotional detachment, pathological retreat from objective reality, interpersonal contact and social involvement, as in some forms of schizophrenia, depression, or schizoid, avoidant, or schizotypal personality disorders.


name: Psychiatric Disorders - Other, Specify, CTCAE


name: Muscular Dystrophy Secondary to Oxidative Phosphorylation Disorder

description: A muscular dystrophy that was caused by a primary disorder of oxidative phosphorylation.


Refractory Malignant Skin Neoplasm

description: Malignant skin neoplasm that is resistant to treatment.


Stage IIA Appendix Carcinoma AJCC v7

description: Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IV Cutaneous Melanoma AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


name: Grade 5 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

description: Death


Encephalitis Infection, CTCAE

description: A disorder characterized by an infectious process involving the brain tissue.


name: Heavy Chain Class-Switched Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by class-switched immunoglobulin heavy chain expression. The majority of cases are IgG-positive.


COVID-19-Associated Albuminuria

description: Albuminuria caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Intraductal papillary neoplasm with low-grade intraepithelial neoplasia

description: An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of mild epithelial atypia.


name: Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Stage 0a Urethral Cancer AJCC v8

description: Stage 0a includes: Ta, N0, M0. Ta: For male penile urethra and female urethra: Non-invasive papillary carcinoma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Skin Papilloma, CTCAE

description: Intervention initiated


name: Grade 3 Prostate Intra-Operative Injury, CTCAE


Grade 3 Jejunal Fistula, CTCAE

description: Invasive intervention indicated


Defective Gamma Heavy Chain Present

description: An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain gamma have been detected in a sample.


Histiocytic Disorder

description: A group of non-neoplastic and neoplastic disorders characterized by the proliferation of histiocytes. This category includes hemophagocytic lymphohistiocytosis and histiocytic and dendritic cell neoplasms.


name: Grade 2 Local Complication of Device and Prosthesis, CTCAE


name: Grade 5 Laryngeal Nerve Dysfunction, CTCAE


Stage IIIB Gallbladder Cancer AJCC v7

description: Stage IIIB includes: T1-3, N1, M0. T1: Tumor invades lamina propria or muscular layer.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. M0: No distant metastasis. (from AJCC 7th Ed.)


Phobia of driving

description: An overwhelming, irrational, and persistent fear of operating a motor vehicle.


Refractory Bladder Carcinoma

description: Bladder carcinoma that does not respond to treatment.


Stage IIIC Anal Cancer AJCC v8

description: Stage IIIC includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Meninges Intra-Operative Injury, CTCAE


Grade 4 Cystitis Noninfective, CTCAE

description: Life-threatening consequences; urgent invasive intervention indicated


Grade 1 Pain of Skin, CTCAE

description: Mild pain


Appendicitis, CTCAE

description: A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent.


name: Grade 1 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


Facial Nerve Palsy Related to Trauma

description: Partial or complete paralysis of the facial muscles of one side of an individual's face that is caused by trauma.


name: Acute Myeloid Leukemia with t(3;21)(q26.2;q22.1); MECOM-RUNX1

description: An acute myeloid leukemia associated with t(3;21)(q26.2;q22.1) resulting in the expression of MECOM-RUNX1 fusion gene.


Inflammatory Cyst

description: A cyst that contains acute, acute and chronic, or chronic inflammatory cells.


Chemotherapy-Related Leukemia

description: A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor.


Grade 5 Urostomy Site Bleeding, CTCAE

description: Death


name: Grade 5 Other Pulmonary and Upper Respiratory, CTCAE


Grade 2 Neonatal Rash, AE

description: An adverse event in a newborn characterized by diffuse rash or target lesions.


Grade 4 Serum Amylase Increased, CTCAE

description: >5.0 x ULN and with signs or symptoms


name: Grade 2 Inferior Vena Cava Intra-Operative Injury, CTCAE


Posterior Fossa Ependymoma

description: A circumscribed ependymoma that arises in the posterior fossa. The diagnosis of posterior fossa ependymoma should be made either when molecular analysis for DNA methylation profiling cannot assign a molecular group (not elsewhere classified -NEC) or when the molecular analysis for DNA methylation profiling was unsuccessful or not reported (not otherwise specified-NOS).


name: Grade 3 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Grade 5 Shingles, CTCAE

description: Death


Duodenal Perforation, CTCAE

description: A disorder characterized by a rupture in the duodenal wall.


name: Grade 2 Ear and Labyrinth Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


WHO Grade 4 Glioma

description: A group of malignant gliomas that includes the following: glioblastoma; diffuse midline glioma; diffuse hemispheric glioma, H3 G34-mutant; astrocytoma, IDH-mutant, grade 4; and diffuse pediatric-type high grade glioma, H3-wildtype and IDH-wildtype.


Recurrent Appendix Adenocarcinoma

description: The reemergence of appendix adenocarcinoma after a period of remission.


name: Grade 2 Lumbar Spine Range of Motion, CTCAE


Grade 3 Hyperthyroidism, CTCAE

description: Severe symptoms; limiting self care ADL; hospitalization indicated


name: Electrocardiogram QT Corrected Interval Prolonged, CTCAE

description: A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval.


Angiomatoid Nodule

description: A nodule that contains vascular spaces lined by endothelial cells.


Grade 3 Hyperkeratosis, CTCAE

description: Limiting self-care ADLs


Pericardial Tamponade, CTCAE

description: A disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium.


Breast Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the breast region.


Intraoperative Breast Injury, CTCAE

description: A finding of damage to the breast parenchyma during a surgical procedure.


Renal hemangioblastoma

description: A rare hemangioblastoma that arises from the kidney.


name: Poorly Differentiated Malignant Neoplasm

description: A neoplasm whose histologic characteristics have regressed and are more similar to stem cells.


Grade 5 Pleural Infection, CTCAE

description: Death


Grade 4 Glucose Intolerance, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Skin Ulceration, CTCAE

description: Combined area of ulcers <1 cm; nonblanchable erythema of intact skin with associated warmth or edema


Advanced Digestive System Carcinoma

description: Digestive system carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Vulvar Squamous Cell Carcinoma, Not Otherwise Specified

description: Vulvar squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


name: Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Otitis Middle Ear Non Infectious, CTCAE


name: Grade 1 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Myelodysplastic/Myeloproliferative Neoplasm with Isolated Isochromosome 17q

description: A new provisional entity under the umbrella of myelodysplastic/myeloproliferative neoplasms, not otherwise specified. It is characterized by the presence of isochromosome 17q. The clinical course is aggressive.


Acute right-sided heart failure

description: New or worsening signs of right heart failure.


name: Grade 2 Urinary Frequency or Urgency, CTCAE


Vestibulocochlear nerve palsy

description: Partial or complete paralysis of the vestibulocochlear nerve.


name: Grade 5 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Vulvar Carcinoma

description: A carcinoma that arises from the vulva and has metastasized to another anatomic site.


name: Grade 3 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Post inflammatory hydrocephalus

description: An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of a central nervous system inflammation.


Current HIV Infection

description: Human immunodeficiency virus infection is evident at the time of testing.


Grade 1 Vaginal Discharge, CTCAE

description: Mild vaginal discharge (greater than baseline for patient)


Localized Cerebral Neoplasm

description: A cerebral neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Grade 3 Pancreatic Duct Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Infection of hemodialysis catheter

description: A local or systemic infection associated with the use of a hemodialysis catheter.


Urothelial carcinoma recurrent

description: The reemergence of urothelial carcinoma after a period of remission.


Cranial Nerve Infection

description: An infectious process affecting a cranial nerve.


name: Grade 5 Glossopharyngeal Nerve Disorder, CTCAE

description: Death


Stage IB Testicular Cancer AJCC v8

description: Stage IB includes: (pT2, N0, M0, S0); (pT3, N0, M0, S0); (pT4, N0, M0, S0). pT2: Testicular cancer which is limited to testis (including rete testis invasion) with lymphovascular invasion or invades hilar soft tissue or epididymis or penetrates visceral mesothelial layer covering the external surface of tunica albuginea with or without lymphovascular invasion. pT3: Testicular cancer in which the tumor invades spermatic cord with or without lymphovascular invasion. pT4: Testicular cancer in which the tumor invades scrotum with or without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


Grade 1 Duodenal Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Tuberculosis of urinary organs

description: The infection of a urinary organ due to Mycobacterium tuberculosis.


Contact dermatitis caused by dichromate

description: Allergic contact dermatitis caused by exposure to dichromate.


Grade 4 Pleural Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Vaginal Non-Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of polygonal squamous cells. Intercellular bridges and cytoplasmic keratinization may be present, but keratin pearls are absent.


Grade 5 Gastritis, CTCAE

description: Death


name: Recurrent Acute Myeloid Leukemia with Myelodysplasia-Related Changes

description: The reemergence of acute myeloid leukemia, myelodysplasia-related after a period of remission.


Micropapillary carcinoma

description: A carcinoma characterized by the presence of a predominant micropapillary pattern.


Transfusion Dependent Beta Thalassemia

description: Beta thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


name: Grade 3 Stoma Pulmonary Hemorrhage, CTCAE


name: Noonan Syndrome-Associated Myeloproliferative Disorder

description: A transient myeloproliferative disorder that is associated with Noonan syndrome and occurs in the first year of life. It is associated with germline mutations in PTPN11, KRAS, NRAS, or RIT1 genes.


Grade 1 Testosterone Deficiency, CTCAE

description: Asymptomatic; mild symptoms with no intervention indicated


name: Locally Recurrent Skin Squamous Cell Carcinoma

description: The reemergence of skin squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Pancreaticobiliary Malunion

description: An abnormality of the pancreatic and biliary ducts in which their junction occurs above the duodenal wall.


Grade 5 Bladder Anastomotic Leak, CTCAE

description: Death


name: Grade 1 Cranial Nerve XII Intra-Operative Injury, CTCAE


Grade 2 Anal Mucositis, CTCAE

description: Symptomatic; medical intervention indicated; limiting instrumental ADL


name: Soft Tissue Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Grade 3 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Dry Eye, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


name: Grade 5 Peritoneal Cavity Hemorrhage, CTCAE


Stage IVA Appendix Carcinoma AJCC v7

description: Stage IVA includes: Any T, N0, M1a, G1.  N0: No regional lymph node metastasis.  M1a: Intraperitoneal metastasis beyond the right lower quadrant, including pseudomyxoma peritonei.  G1: Well differentiated tumor.  (AJCC 7th ed.)


Grade 3 Gallbladder Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 4 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Grade 2 Cholesterol High, CTCAE

description: >300-400 mg/dL; >7.75-10.34 mmol/L


name: Lugano Classification Adult Lymphoma by AJCC v8 Stage

description: A staging system for adult Hodgkin and adult non-Hodgkin lymphomas based on the Lugano classification criteria. This staging system does not apply to ocular adnexal lymphomas (are staged according to the classification for ocular adnexal lymphoma), pediatric lymphomas (are staged according to the classification for pediatric lymphoma), primary cutaneous lymphomas (are staged according to the classification for primary cutaneous lymphoma), and multiple myelomas (are staged according to the classification for plasma cell myeloma). (from AJCC 8th Ed.)


Grade 5 Gastric Ulcer, CTCAE

description: Death


name: Grade 1 Serum Glutamic Oxaloacetic Transaminase, CTCAE


name: Hearing Patients without Baseline Audiogram and Not Enrolled in a Monitoring Program, CTCAE