Nodular and Massive Retinal Gliosis

description: A spectrum of discrete retinal glial proliferations surrounding blood vessels, ranging in size from small nodules to massive lesions that fill the eye. (WHO 2018)


Conventional Schwannoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A common, usually encapsulated benign nerve sheath tumor composed of well-differentiated Schwann cells.


Borderline Broad Ligament Serous Tumor

description: A rare non-invasive tumor that arises from the broad ligament. It is characterized by the presence of serous epithelial cell proliferation and cytological atypia.


Lymphosarcoma of spleen

description: An antiquated term that refers to a non-Hodgkin lymphoma composed of small and medium sized lymphocytes affecting the spleen.


Grade 3 Myocardial Infarction, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction


name: Grade 4 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Metastatic Digestive System Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from any part of the digestive system and has metastasized to another anatomic site.


Ache

description: A dull persistent (usually moderately intense) pain.


Thrombotic Disorder

description: A disorder in which there is pathological development of blood clots within the cardiovascular system.


name: Primary cutaneous acral CD8 positive T-cell lymphoma

description: A primary cutaneous T-cell lymphoproliferative disorder that presents as an acral (peripheral) lesion. It is composed of CD8-positive neoplastic T-lymphocytes. It is usually localized to a single site and has an indolent clinical course. Local or more extensive recurrences have been described in a minority of patients.


Vaginal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the vagina.


name: Grade 3 Joint Intra-Operative Injury, CTCAE


Grade 5 Urinary Tract Infection, CTCAE

description: Death


name: Grade 2 Ileum Stricture or Stenosis, CTCAE


name: Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Secondary Glioblastoma

description: A glioblastoma arising from a lower grade astrocytoma.


Grade 3 Cholesterol High, CTCAE

description: >400-500 mg/dL; >10.34-12.92 mmol/L


name: Grade 4 Leukemia Secondary To Oncology Chemotherapy, CTCAE

description: Present


description: A lymphoproliferative disorder that occurs in a patient with immunodeficiency.


Recurrent Malignant Glioma

description: The reemergence of malignant glioma after a period of remission.


name: Grade 2 Outer Ear Pinna Intra-Operative Injury, CTCAE


name: Grade 1 Skin Intra-Operative Injury, CTCAE


AIDS-Related Hodgkin Lymphoma

description: Hodgkin lymphoma secondary to AIDS. An increased incidence of Hodgkin lymphomas has been observed in HIV positive patients. Most cases are morphologically classified as lymphocyte depleted or mixed cellularity Hodgkin lymphomas.


name: Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Solar Radiation-Related Malignant Neoplasm

description: A malignant neoplasm arising in an anatomic site exposed to solar radiation.


name: Grade 2 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Cranial Nerve VI Neuropathy, CTCAE


name: Grade 3 Pleura Intra-Operative Injury, CTCAE


name: Grade 3 Carotid Artery Intra-Operative Injury, CTCAE


name: Grade 1 Mediastinum Intra-Operative Injury, CTCAE


Basal cell hyperplasia

description: A pathologic hyperplastic process characterized by the proliferation of the cells of the epithelial layer that resemble the basal cells of the lower part of the epidermis.


PSA 50 Percent or Greater than Nadir

description: A finding indicating that the blood concentration of prostate specific antigen in a subject's sample has increased by 50 percent or more over the lowest value recorded for a sample from that subject.


Childhood Nervous System Neoplasm

description: A neoplasm that affects the nervous system during childhood.


Multilocular Thymic Cyst

description: A multicystic lesion that arises from the epithelial component of the thymus gland.  It is usually associated with the presence of lymphoid follicles and degenerative changes.  Although its etiology is unknown, it has been described in patients with HIV infection and in patients with nodular sclerosis Hodgkin lymphoma affecting the thymus gland.


Extra-adrenal paraganglioma, malignant

description: An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic sites.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.


Adult Myofibroma

description: A rare myofibroma that occurs in adults.


name: Grade 3 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Cholecystitis, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 5 Larynx Obstruction and Stenosis, CTCAE


name: Grade 4 Thoracic Duct Intra-Operative Injury, CTCAE


Otitis Externa, CTCAE

description: A disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.


Subcutaneous edema

description: Presence of edema in subcutaneous connective tissue.


Grade 2 Ileal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Unresectable Abdominal Neuroendocrine Neoplasm

description: An abdominal neuroendocrine neoplasm that is not amenable to surgical resection.


name: Grade 4 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Pelvic Rhabdomyosarcoma

description: Rhabdomyosarcoma involving the organs and structures in the pelvis.


Nodular Melanoma

description: A melanoma that arises from the skin and mucosal sites. It is characterized by a vertical growth phase and lacks a significant radial growth phase. It may or may not arise from a pre-existing nevus. Morphologically, it is characterized by the presence of cohesive aggregates of neoplastic melanocytes in the dermis that often exhibit an epithelioid appearance. The overlying epidermis is often involved.


name: Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: AIDS-Related Lymphoma by Working Formulation


name: Lugano Classification Stage II Bulky Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


name: Grade 3 Reduction in Growth Velocity, CTCAE


Non-Neoplastic Urethra Disorder

description: A non-neoplastic disorder affecting the urethra.


Recurrent Spindle Cell Sarcoma

description: The reemergence of spindle cell sarcoma after a period of remission.


Unresectable Gallbladder Adenocarcinoma

description: Adenocarcinoma that arises from the gallbladder and is not amenable to surgical resection.


name: Grade 1 Periventricular Leukomalacia, AE

description: An adverse event in a newborn characterized by transient periventricular echodensities persisting greater than seven days and resolving completely.


name: Grade 3 Esophagus Intra-Operative Injury, CTCAE


Ankle Fracture, CTCAE

description: A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot.


name: Recurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: The reemergence of acute myeloid leukemia with recurrent genetic abnormalities after a period of remission.


name: Usual Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: Acinar adenocarcinoma of the prostate gland characterized by the presence of scattered neuroendocrine cells by immunohistochemistry.


Grade 5 Colonic Perforation, CTCAE

description: Death


name: Grade 2 Disseminated Intravascular Coagulation, CTCAE

description: Laboratory findings with no bleeding


Grade 3 Ear Pain, CTCAE

description: Severe pain; limiting self care ADL


Benign neoplasm of broad ligament

description: A neoplasm that arises from the broad ligament and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Mature Plasmacytoid Dendritic Cell Proliferation Associated with Myeloid Neoplasm

description: A clonal proliferation of plasmacytoid dendritic cells in patients with defined myeloid neoplasms. It is characterized by neoplastic proliferations of mature cells with plasmacytoid morphology in the skin, bone marrow, and very rarely, lymph nodes. Patients are predominantly older males.


name: Serous Endometrial Intraepithelial Carcinoma

description: A precursor of endometrial serous adenocarcinoma characterized by the replacement of the normal endometrial cells by malignant glandular cells that resemble the malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic process is non-invasive. It may coexist with invasive endometrial adenocarcinoma or can be associated with metastases outside the uterus, in the absence of invasive endometrial carcinoma.


name: Grade 5 Neck Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Arrhythmia-Induced Cardiomyopathy

description: A reversible cardiomyopathy presumed to result from the presence of arrhythmias, including the tachycardia-induced cardiomyopathy (T-CM), atrial fibrillation-induced cardiomyopathy (AF-CM), and premature ventricular contraction-induced cardiomyopathy (PVC-CM).


Grade 1 Salivary Gland Fistula, CTCAE

description: Asymptomatic


Stage IIA Prostate Cancer AJCC v7

description: Stage IIA includes: (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X). T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  (AJCC 7th ed.)


name: Grade 3 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

description: Average QTc >= 501 ms; >60 ms change from baseline


Blue rubber bleb nevus syndrome

description: A hemangioma present at birth.  It is characterized by the presence of rubbery skin lesions.


Injury of prostate

description: Trauma to the prostate.


name: Refractory Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that is resistant to treatment.


Corneal Infection, CTCAE

description: A disorder characterized by an infectious process involving the cornea.


name: Grade 3 Small Intestine Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Gastrointestinal Radiation Injury

description: Radiation injury of the gastrointestinal system.


Grade 1 Uterine Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 3 Other Constitutional Symptoms, CTCAE


Severe Sepsis

description: Clinical syndrome defined by the presence of both infection and a systemic inflammatory response that progresses to multi-organ failure.


Thoracoceloschisis

description: A congenital fissure of both the thoracic and abdominal walls.


Grade 2 Depression, CTCAE

description: Moderate depressive symptoms; limiting instrumental ADL


In situ mantle cell neoplasia

description: A neoplastic lymphoid process characterized by the presence of cyclin D1 positive lymphoid cells, typically in the inner mantle zones of lymphoid tissue follicles, in cases that do not suggest the diagnosis of a mantle cell lymphoma. It is often found incidentally and has a low rate of progression.


Bronchial Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site.


name: Clinical Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Testicular Disorder, CTCAE

description: A disorder characterized by abnormal function or appearance of the testis.


Small cell carcinoma, fusiform cell

description: A neuroendocrine carcinoma composed of malignant fusiform small cells.


name: Systemic Hydroa Vacciniforme Lymphoproliferative Disorder

description: Hydroa vacciniforme lymphoproliferative disorder characterized by severe clinical course and associated with fever, lymph node involvement, and involvement of internal organs by EBV-positive T-cells and NK-cells. It usually affects Asian and Latin American individuals.


name: Recurrent Endocervical Adenocarcinoma, Usual-Type

description: The reemergence of endocervical adenocarcinoma, usual-type after a period of remission.


Grade 3 Urinary Incontinence, CTCAE

description: Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL


name: Stage III Renal Pelvis and Ureter Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: For renal pelvis only: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. For ureter only: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Peritoneal Cavity Intra-Operative Injury, CTCAE


Bile Duct Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the bile duct.


name: Myeloid Leukemia, Philadelphia- Negative

description: Myeloid leukemia characterized by the absence of Philadelphia chromosome.


name: Grade 4 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

description: Torsade de pointes; polymorphic ventricular tachycardia; signs/symptoms of serious arrhythmia


Grade 5 Jejunal Perforation, CTCAE

description: Death


name: Grade 3 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Enterocolitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: mucinous cystic neoplasm with moderate dysplasia

description: A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of moderate dysplasia.  The neoplastic columnar mucin-producing epithelial cells form papillary projections or crypt-like invaginations. There is cellular pseudostratification and mitotic activity present.


Hindgut Neuroendocrine Tumor G1

description: A neuroendocrine tumor that arises from the sigmoid colon, descending colon, or rectum.


Stage IA Osteosarcoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Grade 5 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Chronic Leukemia

description: The reemergence of chronic leukemia after a period of remission.


Gallbladder Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site.


name: Grade 5 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Filiform Serrated Adenoma

description: A traditional serrated adenoma characterized by the presence of prominent villous projections of the neoplastic epithelium.


name: Grade 3 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Recurrent Acute Panmyelosis with Myelofibrosis

description: The reemergence of acute panmyelosis with myelofibrosis after a period of remission.


name: Grade 4 Gastrointestinal Stoma Intra-Operative Injury, CTCAE


name: Grade 4 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Mild epithelial dysplasia

description: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. It is characterized by the presence of mild epithelial dysplasia.


name: Grade 3 Alanine Aminotransferase Increased, CTCAE

description: >5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Non-Neoplastic Cardiovascular Disorder

description: A non-neoplastic disorder that affects the heart and/or vessels.  Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.


name: Locally Advanced Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Intestinal Stoma Leak, CTCAE

description: Symptomatic; medical intervention indicated


Grade 3 Duodenal Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Grade 5 Infantile Apnea, AE

description: An apneic adverse event in a newborn which results in death.


Grade 3 Fatigue, CTCAE

description: Fatigue not relieved by rest, limiting self care ADL


dyskeratosis congenita

description: A rare genetic disorder characterized by nail dystrophy, reticulated skin pigmentation especially on the neck and chest, and oral leukoplakia.  In about half the cases mutations in the TERT, TERC, DKC1, or TINF2 genes are identified.  Patients are at an increased risk of developing bone marrow failure, myelodysplastic syndrome, leukemia, or cancer, especially in the head and neck region.


Chronic acquired lymphedema

description: A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation.


name: Grade 5 Neonatal Spontaneous Intestinal Perforation, AE

description: A spontaneous intestinal perforation (SIP) adverse event in a newborn which results in death.


name: Grade 3 Central Nervous System Necrosis, CTCAE

description: Severe symptoms; medical intervention indicated


Grade 5 Otitis Externa, CTCAE

description: Death


name: Grade 2 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Prolapse of Urostomy, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Abdominal Infection, CTCAE

description: A disorder characterized by an infectious process involving the abdominal cavity.


name: Chest Pain Along Right Middle Sternal Border

description: The location of the chest pain is along the right middle border of the sternum.


name: Acute Myeloid Leukemia with Myelodysplasia-Related Gene Mutations

description: A group of acute myeloid leukemias characterized by the presence of gene mutations that are associated with myelodysplasia.


Stage IV Prostate Cancer AJCC v6

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, Any N, M1) (Any G).  T4: Tumor is fixed or invades adjacent structures other than seminal vesicles: bladder neck, external sphincter, rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 6th ed.)


name: General Disorders and Administration Site Conditions, CTCAE


name: Testicular Sertoli Cell Tumor, Lipid Rich Variant

description: A testicular Sertoli cell tumor in which the neoplastic cells have clear and vacuolated cytoplasm due to accumulation of intracytoplasmic lipids.


Grade 2 Dyspnea, CTCAE

description: Shortness of breath with minimal exertion; limiting instrumental ADL


Endometrial Dedifferentiated Carcinoma

description: A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma.


Adult Type Granulosa Cell Tumor

description: A low-grade malignant sex cord-stromal tumor occurring in the ovary and rarely in the testis. It is composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic cells may form various patterns including the microfollicular, which is characterized by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, and diffuse pattern. In females, it affects middle aged to post-menopausal women. Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic and rarely androgenic manifestations may be present. The vast majority of cases present as stage I tumors; however, all tumors have a potential for aggressive clinical course. In males, it is reported in the age range of 16-76 years and the average age at presentation is 44 years. A minority of patients have gynecomastia. Metastases have been reported in a minority of patients.


name: Grade 2 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


name: Grade 2 Tooth Development Disorder, CTCAE

description: Impairment correctable with oral surgery


Stage IA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 3 mm and not more than 5 mm in depth. (FIGO 2009)


Grade 3 Lip Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 2 Cranial Nerve X Intra-Operative Injury, CTCAE


name: Grade 5 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


A1 Hydronephrosis

description: Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of 4 to less than 7 mm at less than 28 weeks, 2) to less than10 mm at greater than or equal to 28 weeks, and 3) may have central calyceal dilation. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Grade 2 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Cecal Hemorrhage, CTCAE

description: Death


name: Grade 2 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Childhood Benign Genitourinary System Neoplasm

description: A childhood neoplasm that arises from any part of the genitourinary system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Pulmonary Valve Disease, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)


Grade 4 Tracheal Stenosis, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


name: Invasive Lipid-Rich Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of lipid laden tumor cells.


Grade 2 Hepatic Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Grade 4 Portal Vein Intra-Operative Injury, CTCAE


Fourth Degree Perineal Laceration

description: Injury to perineum involving anal sphincter complex and internal anal sphincter and anal epithelium. (reVITALize)


Sickle Cell-SS Disease

description: A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.


Steroid-induced myopathy

description: A non-neoplastic disorder affecting the skeletal muscles. It is caused by damage to muscle fibers either by excessive intake of corticosteroids (steroid treatment) or high levels of endogenous corticosteroids due to hormonal abnormalities. Patients usually present with weakness mainly in the proximal muscles of the upper and lower extremities and the neck flexors.


name: Grade 3 Upper Extremity Intra-Operative Injury, CTCAE


name: Grade 1 Left Ventricular Systolic Dysfunction, CTCAE


Grade 3 Small Intestine Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Neonatal Early-Onset Sepsis

description: An infectious disorder of newborn infants that is characterized by a systemic inflammatory response within 72 hours of life and is most commonly caused by bacteria.


name: Grade 1 Gastrointestinal Stoma Leak, CTCAE


Grade 3 Diarrhea, CTCAE

description: Increase of >=7 stools per day over baseline; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL


Rheumatic aortic valve disease

description: A disorder of the aortic valve secondary to rheumatic fever.


name: Grade 1 Hypoxic Ischemic Encephalopathy, AE

description: An adverse event in a newborn clinically classified as perinatal asphyxia, but not resulting in encephalopathy.


Refractory Cervical Carcinoma

description: Cervical carcinoma that is resistant to treatment.


Grade 5 Rectal Obstruction, CTCAE

description: Death


name: Intrahepatic Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the intrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


46,XY Sex Reversal 2

description: Sex reversal in an individual with 46,XY karyotype caused by point mutations or deletions in the NR0B1 gene, encoding nuclear receptor subfamily 0 group B member 1.


name: Grade 3 Intra-Abdominal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Idiopathic 46,XY Differences of Sex Development

description: Conditions affecting individuals whose karyotype is 46,XY that is characterized by atypical development of the internal or external sex structures, or the gonads, and in whom no genetic, environmental, or biochemical causation can be established.


name: Stage IIB Ampulla of Vater Cancer AJCC v7

description: Stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  T3: Tumor invades the pancreas.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Islet Glucagon Cell Hyperplasia

description: Hyperplasia of the alpha cells of the pancreas.


name: Grade 3 Cardiac Troponin T Increased, CTCAE

description: Levels consistent with myocardial infarction as defined by the manufacturer


Malignant neoplasm of urethra local

description: A urethral carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Unresectable Pancreatic Neuroendocrine Carcinoma

description: Pancreatic neuroendocrine carcinoma that is not amenable to surgical resection.


Mucosal Melanoma of the Urinary System

description: A malignant melanocytic neoplasm that arises from a mucosal site of the urinary system.


Exogenous Obesity

description: Obesity caused by caloric intake greater than caloric expenditures.


Biventricular congestive heart failure

description: Heart failure due to dysfunction of both the left and right ventricles.


name: Recurrent Extracranial Malignant Solid Neoplasm

description: The reemergence of an extracranial malignant solid neoplasm after a period of remission.


Proctitis, CTCAE

description: A disorder characterized by inflammation of the rectum.


name: Aleukemic Acute Lymphoblastic Leukemia Cutis

description: Aleukemic acute lymphoblastic leukemia that manifests with cutaneous involvement.


Grade 3 Cognitive Disturbance, CTCAE

description: Severe cognitive disability; significant impairment of work/school/life performance


HPV16 Infection

description: An infection caused by human papillomavirus 16. HPV16 infection is associated with a risk for cervical cancer.


Grade 5 Neonatal Rash, AE

description: A rash adverse event in a newborn which results in death.


Hemangioma of conjunctiva

description: A hemangioma that arises from the conjunctiva.


Failure After First Treatment

description: A lack of response to the first cycle of therapy.


name: Neonatal Spontaneous Intestinal Perforation, AE

description: An adverse event in a newborn characterized by a perforation in the gastrointestinal tract of a newborn with no demonstrable cause.


name: Grade 2 Vein NOS Intra-Operative Injury, CTCAE


name: Grade 4 Intraoperative Neurological Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Esophageal Varices Hemorrhage, CTCAE 5.0

description: A disorder characterized by bleeding from esophageal varices.


Grade 1 Confusion, CTCAE

description: Mild disorientation


Exertional Fatigue

description: Prolonged, extreme exhaustion after physical or mental effort or stress.


Grade 1 Feminization Acquired, CTCAE

description: Mild symptoms; intervention not indicated


Refractory Gallbladder Carcinoma

description: Gallbladder carcinoma that is resistant to treatment.


Ileal Fistula

description: An abnormal communication between the ileum and another organ or cavity.


Vulvar Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the vulva. Representative examples include infection and fibroepithelial polyp.


Recurrent Laryngeal Nerve Palsy, CTCAE

description: A disorder characterized by paralysis of the recurrent laryngeal nerve.


name: Grade 4 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


External hydrocephalus

description: Abnormal increase of cerebrospinal fluid in the subdural space of the brain.


name: Grade 2 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 3 Gastric Fistula, CTCAE

description: Invasive intervention indicated


description: A Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: Advanced Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adult Diffuse Mixed Cell Lymphoma

description: A B-or T-cell non-Hodgkin lymphoma composed of a mixed-sized lymphocytic population occurring in adults.


name: Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Esophageal Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus.  It is characterized by the presence of malignant large cells.


Grade 3 Tendon Reflex Decreased, CTCAE

description: Absence of all reflexes


Grade 2 Hypotension, CTCAE

description: Non-urgent medical intervention indicated


Grade 1 Edema Limbs, CTCAE

description: 5-10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection


Flu Like Symptoms, CTCAE

description: A disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough.


Recurrent Subsequent Malignant Neoplasm

description: The reemergence of a malignant neoplasm other than the original one, after a period of remission.


name: Grade 4 Neuroendocrine ADH Secretion Abnormality, CTCAE


name: Stage IVA Esophageal Squamous Cell Carcinoma


Grade 1 Obstruction Gastric, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Muscle Weakness Left-Sided, CTCAE

description: A disorder characterized by a reduction in the strength of the muscles on the left side of the body.


name: Grade 5 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Eye Melanocytoma

description: A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve or the uvea.


name: Grade 3 Intraoperative Urinary Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


tubular adenoma of gallbladder

description: An adenoma that arises from the gallbladder.  It is characterized by the presence of a tubular growth pattern.


End Organ Damage from Diabetes

description: Irreparable damage to multiple organs/systems which is the result of chronic complications of diabetes.  The affected organs/systems include the cardiovascular system, kidneys, eyes, nervous system, joints and feet.


name: Grade 4 Dental and Teeth and Peridontal Pain, CTCAE


name: Grade 5 Neonatal Culture Negative Sepsis, AE

description: A culture negative neonatal sepsis adverse event in a newborn which results in death.


name: Human Papillomavirus-Related Cervical Carcinoma

description: A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


Stage IV Uterine Corpus Cancer AJCC v6

description: Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1).  T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M1: Distant metastasis (includes metastasis to abdominal lymph nodes other than para-aortic, and/or inguinal lymph nodes: excludes metastasis to vagina, pelvic serosa, or adnexa). (AJCC 6th ed.)


Grade 4 Pharyngeal Mucositis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 3 Sinus Tachycardia, CTCAE

description: Urgent medical intervention indicated


Oligometastatic Gastric Adenocarcinoma

description: Gastric adenocarcinoma that has metastasized to a limited number of sites.


Grade 3 Cystitis Noninfective, CTCAE

description: Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated


name: Grade 3 Irritability in Children Less Than 3 Years of Age, CTCAE


Grade 3 Cushingoid, CTCAE

description: Severe symptoms, medical intervention or hospitalization indicated


Stage IB Vulvar Carcinoma AJCC v6

description: Stage IB includes: T1b, N0, M0.  T1ab Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Appendix Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to appendiceal NETs (carcinoid tumors) (NET G1 and G2, and rare well-differentiated G3). High-grade neuroendocrine carcinomas (NEC), goblet cell carcinoids, mixed adenocarcinomas, and adenocarcinomas of the appendix are not staged using this staging system. (from AJCC 8th Ed.)


Breast Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm arising from the breast.


Grade 3 Cough, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 1 Neonatal Respiratory Insufficiency, AE

description: An adverse event in a newborn characterized by clinical evidence of mildly increased respiratory distress (e.g. increased work of breathing) without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); no change in baseline functioning; no care changes required.


Grade 4 Myocarditis, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support)


MGMT-Methylated Glioblastoma

description: A glioblastoma characterized by the presence of DNA methylation in the promoter region of the MGMT gene. It is associated with improved survival.


Stage III Skin Cancer

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th Ed.)


Mental Retardation, X-linked 21/34

description: An X-linked recessive condition caused by mutation(s) in the IL1RAPL1 gene, encoding interleukin-1 receptor accessory protein-like 1. It is characterized by intellectual disability ranging from moderate mental retardation to high-functioning autism.


name: Endometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with poorly differentiated carcinoma cells.


name: Grade 3 Glomerular Filtration Rate, CTCAE


Grade 2 Hypohidrosis, CTCAE

description: Symptomatic; limiting instrumental ADL


Grade 5 Glucose Intolerance, CTCAE

description: Death


name: Thyroid Stimulating Hormone Increased, CTCAE

description: A disorder characterized by an increase in thyroid stimulating hormone.


name: Grade 4 Salivary Duct Inflammation, CTCAE


Stage I Gallbladder Cancer AJCC v6

description: Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor invades lamina propria or muscle layer.  T1a: Tumor invades lamina propria.  T1b: Tumor invades muscle layer.  N0: No regional metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IV Childhood Large Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


name: Recurrent Fallopian Tube Transitional Cell Carcinoma

description: The reemergence of fallopian tube transitional cell carcinoma after a period of remission.


name: Adverse Event Associated with the Vascular System


name: Neonatal Respiratory Distress Syndrome, AE

description: An adverse event in a newborn characterized by progressive alveolar atelectasis from birth due to an abnormality of synthesis, function or metabolism of surfactant, characterized by respiratory failure and an abnormal chest radiograph showing diffuse reticulogranular densities and air bronchograms.


name: Grade 1 Flashing Lights and Floaters in Vision, CTCAE


Grade 2 Trochlear Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 2 Weight Loss, CTCAE

description: 10-<20% from baseline; nutritional support indicated


name: Stage IIIB Cervical Cancer AJCC v6 and v7

description: Stage IIIB includes: (T3b, Any N, M0); (T1-3, N1, M0).  T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Malignant melanoma, regressing

description: A skin lesion characterized by the disappearance of the melanoma cells from the primary melanoma site. The disappearance of the malignant cells is associated with fibroplasia of the papillary dermis. According to some authors, complete regression of the primary melanoma may occur in 4-8% of patients.


name: Grade 5 Supraventricular Arrhythmia NOS, CTCAE


Foreign body embolism

description: Occlusion of a lumen by a foreign object.


Grade 3 Pleuritic Pain, CTCAE

description: Severe pain; limiting self care ADL


Lentigo simplex

description: The most common form of the skin disorder lentigo, characterized by a single or multiple benign, pigmented macules of unknown etiology that are present at birth or develop in early childhood.


Increased Concomitant Drug Half Life

description: Increased period of time required for the concentration or amount of a concomitant drug in the body to be reduced to exactly one-half of a given concentration or amount.


name: Grade 4 Breast Intra-Operative Injury, CTCAE


name: Hodgkin's disease nodular sclerosis stage II subdiaphragmatic


name: Grade 3 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Stage 0 Cutaneous Melanoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Melanoma in situ.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


Calcifying Odontogenic Cyst

description: A simple odontogenic cyst lined by ameloblastoma-like epithelium, which contains focal accumulations of ghost cells. (WHO 2017)


Testicular Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the testis.


name: Grade 1 Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


Refractory Myeloid Neoplasm

description: A myeloid neoplasm that does not respond to treatment.


Stage IV Bladder Cancer AJCC v6

description: Stage IV includes the following: T4b, N0, M0; Any T, N1, M0; Any T, N2 M0; Any T, N3 M0; Any T, Any N, M1.  T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis.  (AJCC 6th Ed.)


name: Grade 4 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intestinal nematode infection

description: An infection in the gastrointestinal tract by a nematode.


name: Grade 1 Other Hemorrhage and Bleeding, CTCAE


Stage IIA Anal Cancer AJCC v8

description: Stage IIA includes: T2, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Treatment related secondary malignancy

description: The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself.


Grade 2 Vaginal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Grade 1 Productive Cough, CTCAE

description: Occasional/minimal production of sputum with cough


name: Anal Extramucosal (Perianal) Adenocarcinoma

description: An anal adenocarcinoma arising from the lining of an anorectal fistulous tract or the anal glands.  The overlying anal mucosa does not show evidence of neoplastic changes.  It usually presents as a submucosal tumor.


Grade 1 Oral Cavity Fistula, CTCAE

description: Asymptomatic


name: Grade 3 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Trigeminal Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


Trichogerminoma

description: A rare subtype of trichoblastoma characterized by the presence of lobules of basaloid cells. The lobules are separated by fibrous stroma. It is associated with the expression of recurrent FOXK1/GRHL and GPS2/GRHL gene fusions.


name: Childhood Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

description: An acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A occurring in children.


name: Stage IV Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Locally Advanced Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 5 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Tracheal Mucositis

description: An inflammatory process affecting the mucous membrane of the trachea.


name: Lugano Classification Stage II Bulky Adult Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Orbital Contusion

description: Bruising of the skin and soft tissue surrounding the eye.


name: Acute Myeloid Leukemia with a Variant MECOM Rearrangement

description: A term referring to acute myeloid leukemias with rearrangement of the MECOM gene with various genes other than the GATA2 gene.


Cystic Periventricular Leukomalacia

description: Necrosis and softening of the white matter around the ventricles in the brain associated with cystic changes.


Hamartoma of Mature Cardiac Myocytes

description: A non-malignant, focal growth in the heart, composed of unencapsulated nodules of enlarged, hypertrophic, mature cardiac myocytes with a variable amount of collagen and fat.


Prosoposchisis

description: A congenital anatomic defect characterised by a facial cleft that extends from the mouth to the orbit of the eye.


name: Grade 4 Colon or Cecum or Appendix Necrosis, CTCAE


name: Grade 2 Genitourinary Stoma Stricture or Stenosis, CTCAE


name: Advanced Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 5 Intraoperative Hepatobiliary Injury, CTCAE

description: Death


name: Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Sporadic Retinoblastoma

description: A retinoblastoma that occurs in a patient without a family history of the disease.


name: Grade 3 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Anorexia, CTCAE

description: Loss of appetite without alteration in eating habits


Intraoperative Splenic Injury, CTCAE

description: A finding of damage to the spleen during a surgical procedure.


name: Malignant Non-Hodgkin's Lymphoma, Diffuse, Lymphocytic, Poorly Differentiated


Grade 5 Spasticity, CTCAE

description: Death


name: Intra-Operative Injury by Anatomic Descriptor, CTCAE


Recurrent Acute Leukemia

description: The reemergence of acute leukemia after a period of remission.


Locally Advanced Angiosarcoma

description: An angiosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 2 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Intracystic papillary neoplasm with low grade intraepithelial neoplasia

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of mild epithelial atypia.


name: Grade 5 Visceral Arterial Ischemia, CTCAE

description: Death


name: Grade 2 Periventricular Leukomalacia, AE

description: An adverse event in a newborn characterized by transient periventricular echodensities evolving in to small localized fronto-parietal cysts or persistent diffuse echodensities.


name: Stage I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor is limited to the kidney and completely excised. Renal capsule intact, not penetrated by tumor. No tumor invasion of veins or lymphatics of renal sinus. No nodal or hematogenous metastases. No prior biopsy. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 5 Vasculitis, CTCAE

description: Death


name: Grade 4 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Recurrent Myeloid Neoplasm

description: The reemergence of a myeloid neoplasm after a period of remission.


Pansclerotic Morphea

description: A rare, aggressive form of morphea characterized by sclerosis of the dermis, fascia, and muscle over large parts of the body, resulting in contractures and immobility.


Endocrine Therapy-Induced Alopecia

description: Alopecia caused by treatment with endocrine therapy agents.


Grade 5 Myelodysplastic Syndrome, CTCAE

description: Death


Death NOS, CTCAE

description: Death that cannot be attributed to a CTCAE term associated with Grade 5.


name: Transplant-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the skin in a patient with a history of organ transplantation.


name: Grade 2 Fallopian Tube Intra-Operative Injury, CTCAE


name: Radiating Chest Pain Along Right Midclavicular Line

description: The location of the radiating chest pain is along the right midclavicular line.


name: Female Non-Neoplastic Reproductive System Disorder

description: A non-neoplastic disorder that affects the female reproductive system. Representative examples include endometriosis, pelvic inflammatory disease, and endometritis.


Neonatal Late-Onset Sepsis

description: An infectious disorder of newborn infants that is characterized by a systemic inflammatory response beyond 72 hours of life and is most commonly caused by bacteria.


name: Grade 3 Cranial Nerve I Intra-Operative Injury, CTCAE


Recurrent Pancreatic Cystadenocarcinoma

description: The reemergence of pancreatic cystadenocarcinoma after a period of remission.


lipoma of bone

description: A benign neoplasm which is composed of adipocytes and arises from the surface of the bone or the medullary cavity.


Grade 5 Neonatal Convulsion, AE

description: An adverse event in a newborn characterized by death related to suspected seizures.


Extrapulmonary Neuroendocrine Carcinoma

description: A small or large cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Prostate Myeloid Sarcoma

description: Myeloid sarcoma that affects the prostate gland.  It may present in association with or as a site of relapse of acute myeloid leukemia.  Cases of myeloid sarcoma of the prostate gland preceding acute myeloid leukemia have also been reported.


name: Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm

description: Blastic plasmacytoid dendritic cell neoplasm that is resistant to treatment.


name: Grade 5 Otitis External Ear Non Infectious, CTCAE


Hot Flashes, CTCAE

description: A disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling.


Neonatal Epileptic Seizure, AE

description: An adverse event in a newborn characterized by an electroencephalogram (EEG) confirmed paroxysmal surge of electrical activity in the brain that may result in physical or behavioral changes.


Grade 3 Dizziness, CTCAE

description: Severe unsteadiness or sensation of movement; limiting self care ADL


name: Grade 2 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Locally Advanced Gastric Carcinoma

description: A gastric carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Melanocytic Neoplasm

description: A neoplasm that originates from melanocytes and arises from the vulva. This category includes congenital and acquired melanocytic nevus, blue nevus, dysplastic melanocytic nevus, atypical melanocytic nevus of genital type, and melanoma.


Cocaine dependence, continuous

description: Physical or psychological dependence on the drug cocaine which is associated with a pattern of continuous use.


Grade 1 Chest Pain - Cardiac, CTCAE

description: Mild pain


name: Prolonged Intubation After Pulmonary Resection, CTCAE


name: Grade 1 Portal Vein Intra-Operative Injury, CTCAE


Recurrent Adult Hodgkin Lymphoma

description: The reemergence of Hodgkin lymphoma in adulthood after a period of remission.


Classical Poroma

description: A poroma characterized by the presence of cords and aggregates of neoplastic cells in the superficial dermis in connection with the epidermis.


Spermatic Cord Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures).


Environment-Related Malignant Neoplasm

description: Cancers caused by exposure to carcinogens in the general environment


Moist Desquamation

description: A skin reaction characterized by sloughing of the epidermis and serous exudate.


Incidental Gallbladder Carcinoma

description: Gallbladder carcinoma that is discovered incidental to gallbladder surgery for another indication.


Grade 5 Leukoencephalopathy, CTCAE

description: Death


Penile Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the penis.


name: Grade 3 Cecum or Appendix Hemorrhage, CTCAE


name: Sciatic Nerve Intra-Operative Injury, CTCAE


Grade 1 Tumor Pain, CTCAE

description: Mild pain


Advanced Esophageal Carcinoma

description: Esophageal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Gastritis, CTCAE

description: Symptomatic; altered GI function; medical intervention indicated


Stage II Prostate Cancer AJCC v8

description: Stage II includes: IIA: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1); IIB: T1-2, N0, M0, PSA less than 20, Grade Group 2; IIC: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood retinoblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Grade 3 Urinary Tract Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 3 Periorbital Edema, CTCAE

description: Edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated


Colitis, CTCAE

description: A disorder characterized by inflammation of the colon.


Childhood Liver Neoplasm

description: A benign or malignant neoplasm that affects the liver and occurs during childhood.


Grade 2 Dry Mouth, CTCAE

description: Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min


name: Grade 4 Retina Intra-Operative Injury, CTCAE


Physical Examination Finding

description: The result of an evaluation of the body and its functions using visual inspection, palpation, percussion, or auscultation that is performed to determine the presence, absence, or degree of a condition.


Radiating Pain

description: A sensation of discomfort or distress that spreads from one anatomic location to another.


Grade 3 Personality Change, CTCAE

description: Severe personality change; hospitalization not indicated


Grade 1 Vertigo, CTCAE

description: Mild symptoms


Mucosal Nevus

description: A nevus that arises from a mucosal site.


name: Metastatic Bladder Large Cell Neuroendocrine Carcinoma

description: Bladder large cell neuroendocrine carcinoma that has spread to another anatomical site.


name: Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other

description: A rare type of primary cutaneous diffuse large B-cell lymphoma that does not belong in the group of primary cutaneous diffuse large B-cell lymphomas, leg type, or the group of primary cutaneous follicle center lymphomas.  It includes subtypes/entities of diffuse large B-cell lymphoma (e.g. intravascular large B-cell lymphoma, plasmablastic lymphoma, T-cell/histiocyte rich lymphoma) that can involve the skin as the primary anatomic site.  Such cases, unlike their nodal counterparts, usually have an excellent prognosis.


Grade 1 Insomnia, CTCAE

description: Mild difficulty falling asleep, staying asleep or waking up early


name: Grade 5 Ileum Stricture or Stenosis, CTCAE


name: Grade 2 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Surgical and Medical Procedures - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Fatigue, CTCAE

description: Fatigue relieved by rest


Metastatic ocular melanoma

description: Ocular melanoma that has spread from its original site of growth to another anatomic site.


Grade 1 Bronchial Stricture, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hiccups, CTCAE

description: A disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.


name: Grade 5 Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Ventricular Tachycardia, CTCAE

description: Symptomatic, urgent intervention indicated


name: Grade 4 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE


name: Grade 5 Intra-Abdominal Hemorrhage, CTCAE

description: Death


name: Grade 3 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Flashing Lights and Floaters in Vision, CTCAE


Cortical Cataract Grade 4

description: A stage of cortical cataract characterized by greater than 90% of the intrapupillary space obscured by opacity. (Modified LOCS II)


Grade 2 Olfactory Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 2 Jejunal Perforation, CTCAE

description: Invasive intervention not indicated


name: Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 5 Urethra Stricture or Stenosis, CTCAE


name: Low Grade Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia.


Grade 3 Pharyngitis, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Salivary Gland Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Prostate Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gallbladder Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Encephalopathy, CTCAE 5.0

description: A disorder characterized by a pathologic process involving the brain.


name: H-type congenital tracheoesophageal fistula

description: Congenital tracheoesophageal fistula without esophageal atresia.


Testicular Typical Seminoma

description: A testicular seminoma characterized by the presence of uniform round germ cells with glycogen-rich cytoplasm and large nuclei, and a lymphocytic infiltrate.


Grade 4 Laryngeal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 3 Cecal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 4 Salivary Gland Intra-Operative Injury, CTCAE


name: Non-Neoplastic Connective and Soft Tissue Disorder

description: A non-neoplastic disorder that affects the connective and soft tissue.


name: Grade 3 Extraocular Muscle Paresis, CTCAE

description: Bilateral paresis or unilateral paresis causing double vision in peripheral gaze, but not in central gaze


Peritoneal Pain

description: Painful sensation in the peritoneum.


Dental Caries, CTCAE

description: A disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous.


Neonatal Hypertension, AE

description: An adverse event in a newborn characterized by abnormally high blood pressure.


Grade 4 Hematuria, CTCAE

description: Life-threatening consequences; urgent invasive intervention indicated


Grade 2 Vestibular Disorder, CTCAE

description: Symptomatic; limiting instrumental ADL


Neoplasm by Morphology

description: A classification system grouping neoplasms according to their cellular characteristics.


Hypercalcemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood.


name: Recurrent Platinum-Resistant Fallopian Tube High Grade Serous Adenocarcinoma

description: The reemergence of platinum-resistant fallopian tube high-grade serous adenocarcinoma after a period of remission.


Grade 5 Laryngeal Hemorrhage, CTCAE

description: Death


Grade 2 Gastrointestinal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Grade 4 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Small Bowel Perforation NOS, CTCAE


Edema Cerebral, CTCAE

description: A disorder characterized by swelling due to an excessive accumulation of fluid in the brain.


name: High Grade Mucinous Carcinoma Peritonei with Signet Ring Cells

description: A high-grade mucinous adenocarcinoma that has spread to the peritoneum and is characterized by the presence of signet ring malignant cells.


name: Grade 2 Scleral Necrosis and Melt, CTCAE


Grade 2 Dyspareunia, CTCAE

description: Moderate discomfort or pain associated with vaginal penetration; discomfort or pain partially relieved with use of vaginal lubricants or estrogen


Bladder Melanoma

description: A rare melanoma that arises from the bladder mucosa.


name: Grade 5 Central Nervous System Hemorrhage, CTCAE


Testosterone Deficiency, CTCAE

description: A disorder characterized by low testosterone.


Extranodal Lymphoma

description: A non-Hodgkin or Hodgkin lymphoma that arises from an anatomic site other than a lymph node.


Renal Radiation Injury

description: Radiation injury of the kidney.


name: Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Visceral Arterial Ischemia, CTCAE

description: A disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery.


Non-Neoplastic Bladder Disorder

description: A non-neoplastic disorder that affects the urinary bladder. Representative examples include cystitis, cystolithiasis, and urinary bladder rupture.


name: Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIB Appendix Carcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


name: Ampulla of Vater Intestinal-Type Adenocarcinoma

description: An invasive adenocarcinoma arising from the ampulla of Vater. Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells.


name: Refractory T/NK-Cell Lymphoproliferative Disorder

description: T/NK-cell lymphoproliferative disorder that is resistant to treatment.


Acute Myeloid Leukemia with STAT3-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of STAT3-RARA fusion protein.


name: Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Diffuse hyperplasia

description: Hyperplasia characterized by the presence of a diffuse cellular infiltrate.


name: Grade 2 Voice Changes and Dysarthria, CTCAE


Chronic Cancer Pain

description: Chronic pain that results from cancer and/or its treatment. The mechanism for chronic cancer pain may be  inflammatory, neuropathic, ischemic, and/or mechanical in nature.


Grade 3 Floaters, CTCAE

description: Limiting self care ADL


carcinoma of urinary tract

description: A carcinoma that arises from the organs that comprise the urinary tract. This category includes renal pelvis carcinoma, ureter carcinoma, bladder carcinoma, urethral carcinoma, urothelial carcinoma, adenocarcinoma of the urinary tract, clear cell adenocarcinoma of the urinary tract, diverticular carcinoma of the urinary tract, endometrioid adenocarcinoma of the urinary tract, and squamous cell carcinoma of the urinary tract.


name: Grade 4 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Squamous cell carcinoma, microinvasive

description: A squamous cell carcinoma with minimal stromal invasion.


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood retinoblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Duodenal Perforation, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 3 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Vagina Intra-Operative Injury, CTCAE


name: Lower Extremity Intra-Operative Injury, CTCAE


Grade 3 Dry Eye, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


name: Grade 5 Small Intestinal Obstruction, CTCAE

description: Death


name: Grade 5 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cervical Cancer by FIGO Stage 2018

description: A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018.


Scalp Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the skin covering the top and the back of the head.


name: Grade 5 Small Bowel Perforation NOS, CTCAE


name: Grade 5 Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


AIDS-Related Malignant Anal Neoplasm

description: A malignant neoplasm arising from the anus and occurring in HIV-positive patients.  Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma.  Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population.


Testicular Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the testis.


Hyperthyroidism, CTCAE

description: A disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.


name: Grade 5 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Hypertension, CTCAE

description: Adult: Systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg; Pediatric: Systolic/diastolic BP >90th percentile but< 95th percentile; Adolescent: BP >= 120/80 even if < 95th percentile


Grade 2 Photophobia, CTCAE

description: Limiting instrumental ADL


Refractory Malignant Endocrine Neoplasm

description: Malignant endocrine neoplasm that is resistant to treatment.


Nutritional Rickets

description: Rickets due to dietary deficiency of calcium, phosphate, or vitamin D.


name: Refractory Post-Essential Thrombocythemia Myelofibrosis

description: Post-essential thrombocythemia myelofibrosis that is resistant to treatment.


name: Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Adenocarcinoma with metaplasia

description: An adenocarcinoma characterized by the presence of metaplasia.


Testis cancer recurrent

description: Malignant testicular germ cell tumor reemerging after a period of remission.


name: Grade 2 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Low Grade Cervical Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the cervical squamous epithelium without evidence of invasion. It is usually associated with human papillomavirus infection. It is characterized by the presence of mild atypia in the superficial epithelial layer that may be associated with koilocytosis. Maturation is present in the upper two thirds of the epithelium. Mitotic figures are not numerous and are present in the basal third of the epithelium.


name: Grade 2 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Gastric Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Lip Infection, CTCAE

description: Localized, local intervention indicated


name: Abdomen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Grade 2 Portal Vein Intra-Operative Injury, CTCAE


Pseudoangiomatous stromal hyperplasia

description: A benign proliferation of the stromal cells in the breast.  It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present.  It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions.  Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 1

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the NOP10 gene, encoding H/ACA ribonucleoprotein complex subunit 3.


Unresectable Malignant Solid Neoplasm

description: A malignant solid neoplasm that is not amenable to surgical resection.


name: Grade 5 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Crushing Pain

description: A sense of discomfort or distress that is squeezing or excessively compressing.


name: Grade 1 Ophthalmoplegia and Diplopia, CTCAE


Bladder Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm arising from the bladder. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Stage I Prostate Cancer AJCC v8

description: Stage I includes: (cT1a-c, cT2a, N0, M0, PSA less than 10, Grade Group 1); (pT2, N0, M0, PSA less than 10, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. pT2: Prostate cancer which is organ confined. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


Injection Site Reaction, CTCAE

description: A disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection.


Grade 3 Jejunal Perforation, CTCAE

description: Invasive intervention indicated


name: Grade 2 Colon or Cecum or Appendix Fistula, CTCAE


name: Grade 3 Esophagus Stricture or Stenosis, CTCAE


name: Grade 2 Tracheostomy Site Bleeding, CTCAE

description: Moderate bleeding; medical intervention indicated


name: Unresectable Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that is not amenable to surgical resection.


Recurrent Anaplastic Ependymoma

description: The reemergence of anaplastic ependymoma after a period of remission.


name: Grade 1 Neutrophils and Granulocytes, CTCAE


Grade 2 Hypoparathyroidism, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Grade 5 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


description: The presence of bacteria in the blood caused by an infected hemodialysis catheter.


Grade 3 Pancreatitis, CTCAE

description: Severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support)


name: Monoclonal Polymorphic Post-Transplant Lymphoproliferative Disorder


Grade 2 Neonatal Constipation, AE

description: An adverse event in a newborn characterized by reduced number of stools or hard stools; apparent discomfort; minor care changes indicated.


name: Grade 3 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Cranial Nerve III Neuropathy, CTCAE


Grade 3 Tracheal Stenosis, CTCAE

description: Stridor or respiratory distress limiting self care ADL; invasive intervention indicated (e.g., stent, laser)


name: Grade 1 Peripheral Motor Neuropathy, CTCAE

description: Asymptomatic; clinical or diagnostic observations only


Metastatic Carcinoma in the Pancreas

description: A carcinoma that has spread to the pancreas from another anatomic site.


name: Grade 3 Lower Gastrointestinal Hemorrhage NOS, CTCAE


name: Grade 2 Edema of the Head and Neck, CTCAE


Refractory Low Grade Astrocytoma

description: Low grade astrocytoma that is resistant to treatment.


name: Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Pelvic Pain, CTCAE

description: Mild pain


name: Grade 4 Bladder Intra-Operative Injury, CTCAE


name: Grade 1 Vas Deferens Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Salivary Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage IV Renal Pelvis and Ureter Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


TNFRSF8 Low

description: Indicates that low expression of TNFRSF8 has been detected in a sample.


Ampulla of Vater Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region.


name: Posterior Fossa Ependymoma, Not Otherwise Specified

description: A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling was unsuccessful or not reported.


name: Locally Advanced Prostate Adenocarcinoma

description: A prostatic adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastases to abdominal cavity

description: The spread of a malignant neoplasm from a primary site to an unspecified organ in the abdominal cavity.


Vulval Infection, CTCAE

description: A disorder characterized by an infectious process involving the vulva.


name: Grade 1 Pharyngeal Anastomotic Leak, CTCAE


Grade 3 Vasovagal Reaction, CTCAE

description: Present


Conjunctival Oncocytoma

description: A benign epithelial neoplasm that arises from the conjunctiva. It is characterized by the presence of oncocytic cells with abundant eosinophilic and granular cytoplasm.


name: Grade 2 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Blood Corticotrophin Decreased, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 4 Sacral Plexus Intra-Operative Injury, CTCAE


Maternal Hemorrhage

description: Uncontrolled bleeding from a pregnant or a woman who has recently given birth.


Rash Maculo-Papular, CTCAE

description: A disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritis.


Grade 2 Oral Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 5 Salivary Gland Infection, CTCAE

description: Death


Advanced Malignant Skin Neoplasm

description: A malignant neoplasm of the skin that has spread extensively to other anatomic sites or is no longer responding to treatment.


Pancreatic Alpha Cell Adenoma

description: A benign endocrine neoplasm arising from the alpha cells of the pancreas.  It produces glucagon.


name: Grade 5 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8

description: Advanced stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Stage IIA Ampulla of Vater Cancer AJCC v8

description: Stage IIA includes: T3a, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 4 Uterine Perforation, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Depressed Level of Consciousness, CTCAE

description: Difficult to arouse


Stage IVB Vulvar Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


name: Grade 4 Central Nervous System Necrosis, CTCAE


name: Stage III Lentigo Maligna Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Reproductive Endocrine Neoplasm

description: A benign or malignant endocrine neoplasm that arises from the testis or the ovary.


name: Grade 5 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Anemia due to Decreased Production

description: Anemia that results from a decreased rate of erythropoiesis.


name: Melanoma Metastatic in the Central Nervous System

description: A melanoma that has spread to the central nervous system from its original site of growth, through the hematogenous route.


name: Grade 3 Lymphocyte Count Decreased, CTCAE

description: <500-200/mm3; <0.5-0.2 x 10e9/L


Domestic injury

description: Trauma occurring within the confines of the home environment.


name: Grade 3 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


GGT Increased, CTCAE

description: A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water.


Grade 3 Intracranial Hemorrhage, CTCAE

description: Ventriculostomy, ICP monitoring, intraventricular thrombolysis, or invasive intervention indicated; hospitalization


name: Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Extragonadal primary germ cell tumor mixed stage I


name: Grade 2 Skin Intra-Operative Injury, CTCAE


name: Neck Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


name: Grade 5 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Aortic Injury, CTCAE

description: Death


Increased Concomitant Drug AUC

description: Increased area under the plot of plasma concentration of a concomitant drug against time after its administration.


name: Grade 4 Laryngopharyngeal Dysesthesia, CTCAE

description: Life-threatening consequences


name: Grade 1 Esophagus Intra-Operative Injury, CTCAE


name: Grade 5 Neonatal Culture Positive Sepsis, AE

description: A culture positive sepsis adverse event in a newborn which results in death.


Grade 5 Pharyngeal Stenosis, CTCAE

description: Death


Childhood Aneurysmal Bone Cyst

description: An aneurysmal bone cyst that occurs during childhood.


name: Grade 4 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Neonatal Coagulation Disorder, AE

description: An adverse event in a newborn characterized by biochemical or clinical coagulation abnormalities; requiring intervention.


Grade 5 Injury To Carotid Artery, CTCAE

description: Death


Grade 3 Lip Pain, CTCAE

description: Severe pain; limiting self care ADL


Neonatal Sinus Tachycardia, AE

description: An adverse event in a newborn characterized by an abnormally high heart rate for age.


Stage IB Vulvar Cancer AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Lesion measuring more than 2 cm, or any size with stromal invasion of more than 1.0 mm, confined to the vulva and/or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 1 Other Sexual Reproductive Function, CTCAE


Grade 2 Prostatic Obstruction, CTCAE

description: Symptomatic; elective intervention indicated


name: Grade 3 Colon or Cecum or Appendix Necrosis, CTCAE


Stage IIA Pancreatic Cancer AJCC v8

description: Stage IIA includes: T3, N0, M0. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 3 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 1 Lower Extremity Artery Intra-Operative Injury, CTCAE


name: Grade 1 Extraocular Muscle Paresis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only


name: Clonal Hematopoiesis of Indeterminate Potential

description: A term that refers to the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential.


name: Grade 4 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Vagina Intra-Operative Injury, CTCAE


Blood Cardiac Troponin Increased

description: A laboratory test result which indicates increased levels of cardiac troponin in a biological specimen.


Pleural fistula

description: An abnormal communication between the pleural cavity and another anatomic site.


Grade 3 Lung Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 5 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Spermatic Cord Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the spermatic cord.


Refractory Fibrosarcoma

description: Fibrosarcoma that is resistant to treatment.


Metastatic Melanoma in the Skin

description: A melanoma that has spread to the skin from a cutaneous or extracutaneous primary site.


Substance-Induced Anxiety Disorder

description: An anxiety disorder in which the symptoms of anxiety have been determined to be etiologically related to the direct physiological effects of a substance (i.e., a drug of abuse, a medication, or toxin exposure).


Grade 1 Hypoglycemia, CTCAE

description: <LLN-55 mg/dL; <LLN-3.0 mmol/L


name: Hodgkin's disease lymphocyte predominance type recurrent

description: An antiquated term that refers to the reemergence of either nodular lymphocyte predominant Hodgkin lymphoma or lymphocyte-rich classical Hodgkin lymphoma after a period of remission.


name: Clinical Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 2 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Rectal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Grade 2 Sneezing, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Stage IIIC Fallopian Tube Cancer AJCC v8

description: Stage IIIC includes: T3c, N0/N1, M0. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 3 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Vascular hemorrhagic disorders

description: A hemorrhagic disorder that is caused by pathologic changes in the vasculature.


Grade 1 Seizure, CTCAE

description: Brief partial seizure and no loss of consciousness


name: Grade 4 Nasal Cavity Intra-Operative Injury, CTCAE


Grade 5 Myocarditis, CTCAE

description: Death


Pregnancy Mood Swing

description: The fluctuations in the mental and emotional state of an individual during pregnancy.


Adverse Event Associated with Death

description: An adverse event resulting in death.


Peripheral Vascular Insufficiency

description: A condition in which there is inadequate blood flow through the peripheral blood vessels due to intrinsic disease of the vasculature.


name: Rash and Dermatitis Associated with Radiation Excluding Chemoradiation, CTCAE


name: Grade 4 Upper Airway NOS Intra-Operative Injury, CTCAE


name: Child Intoxication With Breast Implant Material Ingredients

description: Children affected by toxins may be due to silicone breast implants and their effects on unborn children and from breastfeeding.


Grade 2 Edema Trunk, CTCAE

description: Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL


name: Grade 5 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Petroleum Hydrocarbon Compound Exposure

description: Environmental, occupational, or consumer-based exposure to the volatile organic compounds and polycyclic aromatic hydrocarbons that are present in and produced during refinement of petroleum products.


Grade 5 Mucositis Oral, CTCAE

description: Death


name: Grade 1 Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Amnestic disorders due to a general medical condition

description: A disorder involving memory impairment (either anterograde or retrograde) that is etiologically linked to the direct physiological consequence of a general medical condition. The memory impairment is not the result of a delirium or dementia.


name: Advanced Gastric Small Cell Neuroendocrine Carcinoma

description: A gastric small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 4 Endocrine Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Intraoperative Cardiac Injury, CTCAE

description: Primary repair of injured organ/structure indicated


Eczema, CTCAE

description: A disorder characterized by skin which becomes itchy, red, inflamed, crusty, thick, scaly, and/or forms blisters.


Subdural Hemorrhage Related to Birth

description: Bleeding within the subdural space occurring during labor and/or delivery.


name: Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread to another anatomic site.


Skin Lesion More Than 200 mm

description: A skin lesion that measures more than 200 mm in greatest dimension.


name: Grade 4 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Pancreatic Mucinous-Cystic Neoplasm, Low Grade

description: A non-invasive mucinous cystic neoplasm that arises from the pancreas and is characterized by the presence of mild dysplasia and absence of mitotic figures.


name: Hereditary coagulation factor deficiency

description: An inherited blood coagulation disorder characterized by deficiency of one of the coagulation factors, resulting in bleeding.


name: Grade 1 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Cytomegalovirus End-Organ Disease

description: Tissue-invasive cytomegalovirus infection, typically seen in solid-organ transplant recipients.


name: Grade 5 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Fibrinogen Decreased, CTCAE

description: <0.25 x LLN; if abnormal, 75% decrease from baseline; absolute value <50 mg/dL


name: Grade 3 Hemorrhage and Bleeding, CTCAE Associated with Surgery, CTCAE


Myelofibrosis due to another disorder

description: Myelofibrosis that develops in patients with a history of hematologic malignancies or toxic injury to the bone marrow.


Grade 4 Spasticity, CTCAE

description: Life-threatening consequences; unable to move active or passive range of motion


Astler-Coller A Colon Carcinoma

description: Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Prostate Ductal Adenocarcinoma, Papillary Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of a papillary growth pattern.


Grade 1 Aortic Valve Disease, CTCAE

description: Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


Grade 2 Dizziness, CTCAE

description: Moderate unsteadiness or sensation of movement; limiting instrumental ADL


name: Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0, GN/A. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. GN/A: Grade non-applicable. (AJCC 8th ed.)


Grade 5 Hypermagnesemia, CTCAE

description: Death


name: Grade 2 Infusion Site Extravasation, CTCAE

description: Erythema with associated symptoms (e.g., edema, pain, induration, phlebitis)


Early Favorable Hodgkin Lymphoma

description: An early Hodgkin lymphoma with favorable prognosis.


Grade 5 Neonatal Pneumothorax, AE

description: A pneumothorax adverse event in a newborn which results in death.


Grade 2 Salivary Gland Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Spinal Fracture, CTCAE

description: A finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken.


Facial Muscle Weakness, CTCAE

description: A disorder characterized by a reduction in the strength of the facial muscles.


Jejunal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the jejunum.


name: Grade 5 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Non-Neoplastic Chronic Respiratory System Disorder

description: A non-neoplastic longstanding disorder of the respiratory system.