Stage IV Laryngeal Cancer AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Supraglottis: Moderately advanced local disease.  Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus).  Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  Subglottis: Moderately advanced local disease.  Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  T4b: Supraglottis, Glottis, and Subglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


name: Stage I Differentiated Thyroid Gland Carcinoma AJCC v7

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Stage I includes: Under 45 years: Any T, Any N, M0.  45 years and older: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M0: No evidence of distant metastasis. (from AJCC 7th Ed.)


Stage IVA Pharyngeal Carcinoma

description: Stage IVA carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Nasopharyngeal Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma that arises from the nasopharynx.


name: Locally Advanced Thyroid Gland Carcinoma

description: Thyroid gland carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Metastatic Oropharyngeal Carcinoma

description: A carcinoma that arises from the oropharynx and has metastasized to another anatomic site.


Stage IVB Laryngeal Cancer AJCC v8

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Supraglottis: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Glottis: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Subglottis: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. N3: metastasis in a lymph node, more than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node, more than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes and any with ENE(+). M0: No distant metastasis. (AJCC 8th ed.)


name: Hypopharyngeal squamous cell carcinoma stage II

description: Stage II includes: T2, N0, M0. T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: minimally invasive follicular carcinoma of the thyroid gland

description: A follicular carcinoma of the thyroid gland showing capsular invasion only.


name: tall cell variant thyroid gland papillary carcinoma

description: A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of tall malignant follicular cells, arranged in papillary and trabecular patterns. Necrotic changes and high mitotic activity are present.


name: Childhood Thyroid Gland Papillary Carcinoma

description: A papillary thyroid gland carcinoma occurring during childhood.


description: A salivary gland polymorphous adenocarcinoma that arises from the oropharynx.


name: Differentiated Thyroid Gland Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of differentiated thyroid gland carcinoma, following the rules of the TNM AJCC v7 classification system.


name: Nasopharyngeal Large Cell Neuroendocrine Carcinoma

description: An extremely rare large cell neuroendocrine carcinoma that arises from the nasopharynx.


oropharyngeal carcinoma

description: Carcinoma, predominantly squamous cell, arising from the epithelial cells of the oropharynx.


name: Refractory Hypopharyngeal Squamous Cell Carcinoma

description: Hypopharyngeal squamous cell carcinoma that does not respond to treatment.


name: Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage III includes: (T3, N2, M0); (T4, N2, M0). T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis. T4: Moderately advanced local disease. Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible or beyond. Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of the larynx. N2: Tumor with metastasis in more than four lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVB Nasopharyngeal Carcinoma AJCC v7

description: Stage IVB includes: Any T, N3, M0.  N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa.  Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho.  It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder.  This would include caudal portions of levels IV and VB.  All cases with lymph nodes (whole or part) in the fossa are considered N3b.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Very advanced local disease. Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N3: Tumor with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. (AJCC 8th ed.)


name: Recurrent Tonsillar Squamous Cell Carcinoma

description: The reemergence of tonsillar squamous cell carcinoma after a period of remission.


glottis squamous cell carcinoma

description: A squamous cell carcinoma of the larynx that arises from the glottic area. It may remain localized for a long period then in late disease stage, it may spread to the opposite true vocal cord, supraglottic and subglottic areas, and the soft tissues of the neck. Hoarseness is the presenting symptom.


Relapsed Hypopharynx Carcinoma

description: The reemergence of hypopharyngeal carcinoma after a period of remission.


name: Locally Recurrent Hypopharyngeal Squamous Cell Carcinoma

description: The reemergence of hypopharyngeal squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Tumor with moderately advanced local disease.  Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible.  Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N, M1). T4a: Tumor with moderately advanced local disease.  Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible.  Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  T4b: Tumor with very advanced local disease.  Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Tumor with metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


name: Stage IVA Oropharyngeal Undifferentiated Carcinoma AJCC v7


name: Hypopharyngeal Carcinoma by AJCC v6 Stage

description: A term that refers to the staging of hypopharyngeal carcinoma according to the American Joint Committee on Cancer, 6th edition.


name: Recurrent Pharyngeal Squamous Cell Carcinoma

description: The reemergence of pharyngeal squamous cell carcinoma after a period of remission.


name: Nasopharyngeal lymphoepithelioma stage I

description: Stage I includes: T1, N0, M0. T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage 0 Oropharyngeal (p16-Negative) Carcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Refractory Oropharyngeal Squamous Cell Carcinoma

description: Oropharyngeal squamous cell carcinoma that does not respond to treatment.


name: Recurrent Oropharyngeal Undifferentiated Carcinoma

description: The reemergence of oropharyngeal undifferentiated carcinoma after a period of remission.


name: Locally Advanced Thyroid Gland Anaplastic Carcinoma

description: Thyroid gland anaplastic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Unresectable Thyroid Gland Papillary Carcinoma

description: Thyroid gland papillary carcinoma that is not amenable to surgical resection.


Solid papillary carcinoma with invasion

description: A papillary carcinoma of the thyroid gland which is encapsulated and resembles an encapsulated follicular neoplasm. Capsular invasion is present. The malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland.


name: Invasive Follicular Variant Thyroid Gland Papillary Carcinoma

description: A nonencapsulated, infiltrating papillary carcinoma of the thyroid gland characterized by the predominance of follicular structures. The malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland.


name: Stage III Thyroid Gland Medullary Carcinoma AJCC v7

description: Stage III includes: (T1, N1a, M0); (T2, N1a, M0); (T3, N1a, M0). T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues).  N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes).  M0: No distant metastasis. (AJCC 7th ed.)


Oropharyngeal lymphoepithelioma stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Stage II Nasopharyngeal Carcinoma AJCC v7

description: Stage II includes: (T1, N1, M0); (T2, N0, M0); (T2, N1, M0).  T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Stage IV Laryngeal Cancer AJCC v8

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (Any T, N3, M0); (T4b, Any N, M0); IVC: (Any T, Any N, M1). T4a: Supraglottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, cricoid cartilage, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Subglottis: Moderately advanced local disease. Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). T3: Supraglottis: Tumor is limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage. Glottis: Tumor is limited to the larynx with vocal cord fixation and /or invades the paraglottic space, and/or inner cortex of the thyroid cartilage. Subglottis: Tumor is limited to the larynx with vocal cord fixation and/or invades the paraglottic space and/or inner cortex of the thyroid cartilage. T1: Supraglottis: Tumor is limited to one subsite of supraglottis with normal vocal cord mobility. Glottis: Tumor is limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility. Subglottis: Tumor is limited to the subglottis. T2: Supraglottis: Tumor invades the mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of the tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx. Glottis: Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility. Subglottis: Tumor extends to vocal cord(s) with normal or impaired mobility. T4b: Supraglottis: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Glottis: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Subglottis: Very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-); or metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). N3: metastasis in a lymph node, more than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node, more than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes and any with ENE(+). M0: No distant metastasis. M1: distant metastasis. (AJCC 8th ed.)


Postcricoid Squamous Cell Carcinoma

description: A squamous cell carcinoma of the hypopharynx that arises from the postcricoid region.


name: Stage III Thyroid Gland Papillary Carcinoma AJCC v8

description: Stage III includes: 55 years and older: T4a, Any N, M0. T4a: Gross extrathyroidal extension invading subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve from a tumor of any size. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (-). M0: No distant metastasis. (AJCC 8th ed.)


Laryngeal Neuroendocrine Carcinoma

description: A rare neuroendocrine carcinoma that arises from the larynx.


Stage IV Laryngeal Cancer AJCC v6

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4: (Supraglottis) T4a: Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). T4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. (Glottis) T4a: Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). T4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. (Subglottis) T4a: Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  T4b: Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in greatest dimension. N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension.  M1: Distant metastasis. (AJCC 6th ed.)


nasopharyngeal carcinoma

description: A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma.


name: Unresectable Thyroid Gland Follicular Carcinoma

description: Thyroid gland follicular carcinoma that is not amenable to surgical resection.


name: Stage III Nasopharyngeal Carcinoma AJCC v8

description: Stage III includes: (T1, N2, M0); (T0, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T1: Tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal involvement. T0: No tumor identified, but EBV-positive cervical node(s) involvement is present. T2: Tumor with extension to parapharyngeal space, and/or adjacent soft tissue involvement (medial pterygoid, lateral pterygoid, prevertebral muscles). T3: Tumor infiltrating bony structures at skull base, cervical vertebrae, pterygoid structures, and/or paranasal sinuses. N0: No regional lymph node metastasis. N1: Tumor with unilateral metastasis in cervical lymph node(s), and/or unilateral or bilateral metastasis in retropharyngeal lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. N2: Tumor with bilateral metastasis in cervical lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVB Thyroid Gland Follicular Carcinoma AJCC v8

description: Stage IVB includes: 55 years and older: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Childhood Thyroid Gland Medullary Carcinoma

description: A medullary thyroid gland carcinoma occurring in childhood.


name: Nasopharyngeal squamous cell carcinoma stage III

description: Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor.  T3: Nasopharyngeal cancer with tumor involving bony structures of skull base and/or paranasal sinuses.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)


Advanced Oropharyngeal Carcinoma

description: Oropharyngeal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1a, M0); (T1, N1b, M0); (T2, N1b, M0); (T3, N1b, M0); (T4a, N1b, M0). T4a: Moderately advanced local disease. Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve. T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland. T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). N0: No regional lymph node metastasis. N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). N1b: Metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII). M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVA Oropharyngeal Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Tumor with moderately advanced local disease.  Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible.  Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.  (AJCC 7th ed.)


name: Metastatic Squamous Cell Carcinoma of the Larynx

description: A squamous cell carcinoma of the larynx that has spread from the original site of growth to another anatomic site.


name: Thyroid Gland Papillary Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of papillary thyroid gland carcinoma, following the rules of the TNM AJCC v7 classification system.


name: Oropharyngeal Human Papillomavirus-Related Keratinizing Squamous Cell Carcinoma

description: An oropharyngeal human papillomavirus-related squamous cell carcinoma characterized by the presence of keratinization and intercellular bridges.


name: Stage IVA Hypopharyngeal Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Tumor with moderately advanced local disease.  Tumor invades the thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue.  Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  T3: Tumor measuring more than 4 cm in greatest dimension or tumor with fixation of hemilarynx or extension to esophagus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.  (AJCC 7th ed.)


name: Metastatic Nasopharyngeal Undifferentiated Carcinoma

description: An undifferentiated carcinoma that arises from the nasopharynx and has metastasized to another anatomic site.


adenoid cystic carcinoma of oropharynx

description: A adenoid cystic carcinoma that involves the oropharynx.


name: Locally Advanced Hypopharyngeal Squamous Cell Carcinoma

description: Hypopharyngeal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Carcinoma larynx recurrent

description: The reemergence of laryngeal carcinoma after a period of remission.


name: Unresectable Thyroid Gland Medullary Carcinoma

description: Thyroid gland medullary carcinoma that is not amenable to surgical resection.


name: Stage II Hypopharyngeal Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Stage I Thyroid Gland Papillary Carcinoma Under 55 Years AJCC v8

description: Stage I includes: Any T, Any N, M0. M0: No distant metastasis. (from AJCC 8th Ed.)


carcinoma of supraglottis

description: A carcinoma of the larynx that arises from the supraglottic area.


laryngeal mucoepidermoid carcinoma

description: A rare mucoepidermoid carcinoma of the larynx. It usually arises from the supraglottic area. Hoarseness and dysphagia are the presenting symptoms.


name: Stage III Thyroid Gland Medullary Carcinoma AJCC v8

description: Stage III includes: T1-3, N1a, M0. T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but less than 4 cm in greatest dimension limited to the thyroid. T3: Tumor measuring 4 cm or more in greatest dimension or with extrathyroidal extension. N1a: Metastasis to level VI or VII (pretracheal, paratracheal, or prelaryngeal/Delphian, or upper mediastinal) lymph nodes. This can be unilateral or bilateral disease. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage II Hypopharyngeal Carcinoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invading more than one subsite of hypopharynx or an adjacent site, or measuring more than 2 cm but not more than 4 cm in greatest dimension without fixation of hemilarynx. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Recurrent Thyroid Gland Anaplastic Carcinoma

description: The reemergence of thyroid gland anaplastic carcinoma after a period of remission.


name: Childhood Thyroid Gland Spindle Epithelial Tumor with Thymus-Like Elements

description: A spindle epithelial tumor with thymus-like elements that arises from the thyroid gland and occurs during childhood.


name: Oropharyngeal squamous cell carcinoma stage II

description: Stage II includes: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Childhood Thyroid Gland Carcinoma

description: A rare carcinoma of the thyroid gland that occurs during childhood.


name: Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7

description: Stage IVB includes: T4b, Any N, M0.  T4b: Very advanced disease.  Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage I Differentiated Thyroid Gland Carcinoma 45 Years and Older AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M0: No evidence of distant metastasis. (from AJCC 7th Ed.)


name: Metastatic Poorly Differentiated Thyroid Gland Carcinoma

description: Poorly differentiated thyroid gland carcinoma that has spread from its original site of growth to another anatomic site.


name: Laryngeal Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the larynx.


name: Encapsulated Variant Thyroid Gland Papillary Carcinoma

description: A typical papillary thyroid gland carcinoma that is totally surrounded by a fibrous capsule, which may be intact or only focally infiltrated by tumor growth. It accounts for about 10% of all cases of papillary thyroid gland carcinoma and has an excellent prognosis. Regional nodal metastases may be present, but bloodborne metastases are rare. The survival rate is nearly 100%. (WHO 2017)


Pharyngeal Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of pharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage IV Nasopharyngeal Carcinoma AJCC v8

description: Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); (Any T, N3, M0); IVB (Any T, Any N, M1). T4: Tumor with intracranial extension, involvement of cranial nerves, hypopharynx, orbit, parotid gland, and/or extensive soft tissue infiltration beyond the lateral surface of the lateral pterygoid muscle.  N0: No regional lymph node metastasis. N1: Tumor with unilateral metastasis in cervical lymph node(s), and/or unilateral or bilateral metastasis in retropharyngeal lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. N2: Tumor with bilateral metastasis in cervical lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. N3: Tumor with unilateral or bilateral metastasis in cervical lymph node(s), larger than 6 cm in greatest dimension, and/or extension below the caudal border of cricoid cartilage. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage II Thyroid Gland Follicular Carcinoma Under 55 Years AJCC v8

description: Stage II includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Tumor with very advanced local disease.  Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension.  M0: No distant metastasis.  (AJCC 7th ed.)


trabecular follicular adenocarcinoma

description: A morphologic variant of papillary carcinoma of the thyroid gland that predominantly affects children.  It is characterized by the presence of a solid growth pattern.  The malignant cells have nuclear features that are characteristic of papillary carcinomas of the thyroid gland.


Metastatic Parathyroid Gland Carcinoma

description: A parathyroid gland carcinoma that has spread to other anatomic sites.


name: Refractory Thyroid Gland Medullary Carcinoma

description: Thyroid gland medullary carcinoma that is resistant to treatment.


Laryngeal Lymphoepithelial Carcinoma

description: A rare and aggressive carcinoma that arises from the larynx.  It is characterized by the presence of an undifferentiated carcinoma accompanied by a prominent reactive lymphoplasmacytic infiltrate.


name: thyroid gland spindle cell tumor with thymus-like differentiation

description: A rare, slow growing, primary carcinoma of the thyroid gland characterized by a lobulated architectural pattern and the presence of a biphasic cellular population composed of spindle epithelial cells and glandular cells. A small number of cases are composed exclusively of spindle epithelial cells or glandular cells.


name: Posterior Pharyngeal Wall Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the posterior wall of the pharynx.


name: Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant

description: A squamous cell carcinoma that arises from the larynx. It is characterized by the presence of a malignant spindle cell cellular component. In some cases, there is a biphasic morphology due to the presence of a well-differentiated squamous cell carcinoma component. The latter is either in situ or invasive squamous cell carcinoma.


name: Differentiated Thyroid Gland Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of differentiated thyroid gland carcinoma, following the rules of the TNM AJCC v8 classification system.


name: Stage IVA Hypopharyngeal Carcinoma AJCC v8

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Moderately advanced local disease. Tumor invades thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue. Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat. T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or smaller in greatest dimension. T2: Tumor invading more than one subsite of hypopharynx or an adjacent site, or measuring more than 2 cm but not more than 4 cm in greatest dimension without fixation of hemilarynx. T3: Tumor larger than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus. N0: No regional lymph node metastasis. N1: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


name: Stage III Oropharyngeal Carcinoma AJCC v6

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N2, M0).  T3: Tumor more than 4 cm in greatest dimension.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6cm in greatest dimension.  M0: No distant metastasis. (AJCC 6th ed.)


name: Metastatic Differentiated Thyroid Gland Carcinoma

description: Differentiated thyroid gland carcinoma that has spread from its original site of growth to another anatomic site.


Metastatic Pharyngeal Carcinoma

description: A carcinoma that arises from the pharynx and has metastasized to another anatomic site.


name: Thyroid Gland Follicular Carcinoma, Signet Ring Cell Variant

description: A morphologic variant of follicular carcinoma of the thyroid gland characterized by the presence of malignant follicular cells with cytoplasmic vacuoles and eccentrically placed nuclei.


name: Stage II Nasopharyngeal Carcinoma AJCC v6

description: Stage II includes: IIA (T2a, N0, M0); IIB (T1, N1, M0), (T2, N1, M0), (T2a, N1, M0); (T2b, N0, M0); (T2b, N0, M0); (T2b, N1, M0).  T2: Tumor extends to soft tissues.  T2a: Tumor extends to the oropharynx and/or nasal cavity without parapharyngeal extension.  T2b: Any tumor with parapharyngeal extension.  N1: Unilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  M0: No distant metastasis.  (AJCC 6th ed.)


name: Stage IVC Oropharyngeal Undifferentiated Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Pharyngeal cancer recurrent

description: The reemergence of carcinoma of the pharynx after a period of remission.


name: Thyroid Gland Papillary Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of papillary thyroid gland carcinoma, following the rules of the TNM AJCC v8 classification system.


name: Stage II Differentiated Thyroid Gland Carcinoma 45 Years and Older AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M0: No evidence of distant metastasis.  (from AJCC 7th Ed.)


Thyroid Gland Secretory Carcinoma

description: An invasive adenocarcinoma of the thyroid gland characterized by the presence of cells that secrete eosinophilic material. It is composed of cystic spaces, tubular structures, and solid areas. ETV6 translocations and ETV6-NTRK3 fusion are present.


Refractory Thyroid Gland Carcinoma

description: Thyroid gland carcinoma that does not respond to treatment.


name: HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of HPV-mediated (p16-positive) oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage II Thyroid Gland Follicular Carcinoma AJCC v7

description: Stage II includes: Under 45 years: Any T, Any N, M1.  45 years and older: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M1: Distant metastasis.  M0: No evidence of distant metastasis.  (from AJCC 7th Ed.)


carcinoma in situ of hypopharynx

description: A in situ carcinoma that involves the hypopharynx.


name: Stage I Differentiated Thyroid Gland Carcinoma Under 45 Years AJCC v7

description: Stage I includes: Any T, Any N, M0.  M0: No evidence of distant metastasis.  (from AJCC 7th Ed.)


thyroid gland mucoepidermoid carcinoma

description: A primary, low grade carcinoma of the thyroid gland composed of groups of squamoid and mucous cells, surrounded by fibrous tissue. Prominent cystic structures may be present. The clinical course is usually indolent.


name: Stage IVC Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7


Oropharyngeal lymphepithelioma

description: A non-keratinizing carcinoma arising from the oropharynx.  It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate.


name: Stage IVB Laryngeal Verrucous Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Supraglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Glottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Subglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Recurrent Thyroid Gland Medullary Carcinoma

description: The reemergence of thyroid gland medullary carcinoma after a period of remission.


name: Unresectable Oropharyngeal Undifferentiated Carcinoma

description: Oropharyngeal undifferentiated carcinoma that is not amenable to surgical resection.


name: Stage IVB Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v7

description: Stage IVB includes: T4b, Any N, M0.  T4b: Anaplastic carcinoma with gross extrathyroid extension.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IVC Hypopharyngeal Carcinoma AJCC v7


name: Thyroid Gland Follicular Carcinoma, Clear Cell Variant

description: A morphologic variant of follicular carcinoma of the thyroid gland characterized by the predominance of malignant follicular clear cells.  These cells lack the nuclear features that characterize the papillary carcinomas of the thyroid gland.


name: Metastatic Pharyngeal Squamous Cell Carcinoma

description: Pharyngeal squamous cell carcinoma that has spread from the original site of growth to another anatomic site.


name: Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7

description: Stage IVB includes: T4b, Any N, M0. T4b: Very advanced disease. Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IV Differentiated Thyroid Gland Carcinoma AJCC v8

description: Stage IV includes: IVA: 55 years and older: T4b, Any N, M0; IVB: 55 years and older: Any T, Any N, M1. T4b: Gross extrathyroidal extension invading prevertebral fascia or encasing the carotid artery or mediastinal vessels from a tumor of any size. M0: No distant metastasis. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage IVA Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v8

description: Stage IVA includes: T1-T3a, N0/NX, M0. T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Warthin-Like Variant Thyroid Gland Papillary Carcinoma

description: A rare variant of papillary thyroid gland carcinoma characterized by the presence of eosinophilic large cells lining the papillae and a brisk lymphoplasmacytic infiltrate in the papillary stalks.


Stage IVC Laryngeal Cancer AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


parathyroid gland carcinoma

description: A very rare, slow-growing, clinically serious endocrine tumor that generally develops in mid-adulthood. PRTC presents as a palpable painless mass in the neck and causes severe hypercalcemia and related symptoms, non-specific gastrointestinal manifestations, as well as renal and bone complications related to primary hyperparathyroidism (nephrolithiasis, impaired renal function, osteoporosis, bone pain, and pathologic fractures, etc.). Some PRTCs are however non-functioning tumors.


name: Stage IVB Hypopharyngeal Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Tumor with very advanced local disease.  Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension.  M0: No distant metastasis.  (AJCC 7th ed.)


Nasopharyngeal Differentiated Carcinoma

description: A nonkeratinizing nasopharyngeal carcinoma characterized by the presence of cells without prominent nucleoli, cellular stratification, and a lymphoplasmacytic infiltrate.


name: Stage IV Thyroid Gland Follicular Carcinoma AJCC v8


Childhood Laryngeal Carcinoma

description: A rare carcinoma of the larynx that occurs during childhood.


name: Thyroid Gland Follicular Carcinoma, Widely Invasive

description: A follicular carcinoma of the thyroid gland with extension into surrounding thyroid or extrathyroid tissues.


Childhood Parathyroid Gland Carcinoma

description: A rare carcinoma of the parathyroid gland that occurs during childhood.


glottis verrucous carcinoma

description: An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the glottic area of the larynx. It usually presents with hoarseness.


Laryngeal Cancer by AJCC v7 Stage

description: A term that refers to the staging of laryngeal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage IVA Laryngeal Cancer AJCC v8

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Supraglottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, cricoid cartilage, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Subglottis: Moderately advanced local disease. Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). T3: Supraglottis: Tumor is limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage. Glottis: Tumor is limited to the larynx with vocal cord fixation and /or invades the paraglottic space, and/or inner cortex of the thyroid cartilage. Subglottis: Tumor is limited to the larynx with vocal cord fixation and/or invades the paraglottic space and/or inner cortex of the thyroid cartilage. T1: Supraglottis: Tumor is limited to one subsite of supraglottis with normal vocal cord mobility. Glottis: Tumor is limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility. Subglottis: Tumor is limited to the subglottis. T2: Supraglottis: Tumor invades the mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of the tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx. Glottis: Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility. Subglottis: Tumor extends to vocal cord(s) with normal or impaired mobility. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-); or metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


name: Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma

description: An oropharyngeal squamous cell carcinoma which is negative for p16INK4a by immunohistochemistry. This negative immunohistochemistry result does not exclude human papillomavirus infection.


name: Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma

description: The reemergence of keratinizing squamous cell carcinoma of the nasopharynx after a period of remission.


name: Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage III includes: (T0, N3, M0); (T1, N3, M0); (T2, N3, M0); (T3, N3, M0); (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); (T4, N3, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis. T4: Tumor with moderately advanced local disease. Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible or beyond. Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of the larynx. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or more ipsilateral lymph nodes, none larger than 6 cm. N2: Tumor with contralateral or bilateral lymph nodes metastasis, none larger than 6 cm. N3: Tumor with lymph node(s) metastasis, larger than 6 cm. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage II Laryngeal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: (Supraglottis) Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx.  (Glottis) Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility.  (Subglottis) Tumor extends to vocal cord(s) with normal or impaired mobility. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


thyroid gland mucinous carcinoma

description: A rare primary carcinoma of the thyroid gland characterized by the presence of clusters of malignant epithelial cells associated with abundant extracellular mucin deposition.


name: Nasopharyngeal squamous cell carcinoma stage II

description: Stage II includes: (T1, N1, M0); (T2, N0, M0); (T2, N1, M0).  T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage I Oropharyngeal (p16-Negative) Carcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or smaller in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: columnar cell variant thyroid gland papillary carcinoma

description: A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of pseudostratified malignant follicular cells.


undifferentiated carcinoma of larynx

description: An undifferentiated carcinoma that arises from the larynx.  This category includes lymphoepithelial carcinoma and giant cell carcinoma.


name: Stage I Thyroid Gland Medullary Carcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Supraglottis: Tumor limited to one subsite of supraglottis with normal vocal cord mobility. Glottis: Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility.  Subglottis: Tumor limited to the subglottis.  T2: Supraglottis: Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx.  Glottis: Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility.  Subglottis: Tumor extends to vocal cord(s) with normal or impaired mobility. T3: Supraglottis: Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, pre-epiglottic tissues, paraglottic space, and/or inner cortex of thyroid cartilage.  Glottis: Tumor limited to the larynx with vocal cord fixation and/or invasion of paraglottic space, and/or inner cortex of the thyroid cartilage.  Subglottis: Tumor limited to larynx with vocal cord fixation.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Postcricoid cancer

description: A carcinoma of the hypopharynx that arises from the postcricoid region.


name: Metastatic Squamous Cell Carcinoma of the Oropharynx

description: A squamous cell carcinoma of the oropharynx which has spread from the original site of growth to another anatomic site.


name: Stage IV Thyroid Gland Papillary Carcinoma AJCC v8

description: Stage IV includes: IVA: 55 years and older: T4b, Any N, M0; IVB: 55 years and older: Any T, Any N, M1. T4b: Gross extrathyroidal extension invading prevertebral fascia or encasing the carotid artery or mediastinal vessels from a tumor of any size. M0: No distant metastasis. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage I Hypopharyngeal Carcinoma AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


subglottis squamous cell carcinoma

description: A squamous cell carcinoma of the larynx that arises from the subglottic area. Symptoms include dyspnea and stridor. It spreads to the hypopharynx, trachea, and thyroid gland.


Metastatic Thyroid Gland Carcinoma

description: Thyroid gland carcinoma that has spread from its original site of growth to another anatomic site.


name: Advanced Differentiated Thyroid Gland Carcinoma

description: Differentiated thyroid gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: familial papillary or follicular thyroid carcinoma

description: A papillary or follicular thyroid gland carcinoma with a genetic component that develops within the same family. Current studies suggest that it is inherited in an autosomal dominant pattern. It is often multifocal and bilateral and usually affects younger patients.


name: Oropharyngeal lymphoepithelioma stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Oropharyngeal Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of oropharyngeal carcinoma according to the American Joint Committee on Cancer, 7th edition.


name: Stage I Differentiated Thyroid Gland Carcinoma 55 Years and Older AJCC v8

description: Stage I includes: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage II Oropharyngeal Carcinoma

description: Stage II includes: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Laryngeal Cancer by AJCC v6 Stage

description: A term that refers to the staging of laryngeal carcinoma according to the American Joint Committee on Cancer, 6th edition.


name: Stage II Thyroid Gland Medullary Carcinoma AJCC v7

description: Stage II includes: (T2, N0, M0); (T3, N0, M0).  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: follicular variant thyroid gland papillary carcinoma

description: A nonencapsulated variant of papillary carcinoma of the thyroid gland characterized by the predominance of follicular structures. The malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland.


name: Stage II Oropharyngeal Undifferentiated Carcinoma AJCC v6 and v7


name: Stage II Laryngeal Verrucous Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: (Supraglottis) Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx.  (Glottis) Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility.  (Subglottis) Tumor extends to vocal cord(s) with normal or impaired mobility. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Locally Advanced Oropharyngeal Squamous Cell Carcinoma

description: An oropharyngeal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


nasopharyngeal squamous cell carcinoma

description: A squamous cell carcinoma that arises from the nasopharynx.


name: Hypopharyngeal Papillary Squamous Cell Carcinoma

description: A variant of squamous cell carcinoma that arises from the hypopharynx. It is characterized by exophytic and papillary growth. The papillae are covered by a malignant stratified squamous epithelium.


name: Stage 0 Laryngeal Squamous Cell Carcinoma AJCC v6, v7, and v8

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


name: Stage IVA Nasopharyngeal Carcinoma AJCC v7

description: Stage IVA includes: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)


name: Thyroid Gland Anaplastic Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of thyroid gland anaplastic carcinoma, following the rules of the TNM AJCC v7 classification system.


carcinoma of soft palate

description: A carcinoma that arises from the soft palate. The majority are squamous cell carcinomas.


name: Refractory Thyroid Gland Anaplastic Carcinoma

description: Thyroid gland anaplastic carcinoma that does not respond to treatment.


Stage I Laryngeal Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Supraglottis: Tumor is limited to one subsite of supraglottis with normal vocal cord mobility. Glottis: Tumor is limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility. Subglottis: Tumor is limited to the subglottis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Resectable Oropharyngeal Squamous Cell Carcinoma

description: Oropharyngeal squamous cell carcinoma that is amenable to surgical resection.


name: Locally Advanced Oropharyngeal Carcinoma

description: Oropharyngeal carcinoma that has spread to nearby tissues or lymph nodes.


name: Stage IV Hypopharyngeal Carcinoma AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Tumor with moderately advanced local disease.  Tumor invades the thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue.  Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  T3: Tumor measuring more than 4 cm in greatest dimension or tumor with fixation of hemilarynx or extension to esophagus.  T4b: Tumor with very advanced local disease.  Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


intrathyroid thymic carcinoma

description: A rare primary carcinoma of the thyroid gland, composed of groups of carcinoma cells with thymic epithelial differentiation.


name: Advanced Thyroid Gland Anaplastic Carcinoma

description: Thyroid gland anaplastic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


epiglottis cancer

description: A malignant neoplasm that affects the epiglottis. The vast majority of cases are squamous cell carcinomas.


name: Stage IVB Hypopharyngeal Carcinoma AJCC v8

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Very advanced local disease. Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures. N3: Tumor with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. (AJCC 8th ed.)


name: Differentiated High Grade Thyroid Gland Carcinoma

description: A follicular-derived thyroid gland carcinoma that is histologically differentiated and has high-grade features.


Locally Advanced Pharyngeal Carcinoma

description: Pharyngeal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Refractory Thyroid Gland Papillary Carcinoma

description: Thyroid gland papillary carcinoma that is resistant to treatment.


pharyngeal adenoid cystic carcinoma

description: An adenoid cystic carcinoma that arises from the pharynx.


name: Stage I Nasopharyngeal Carcinoma AJCC v7

description: Stage I includes: T1, N0, M0. T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Thyroid Gland Follicular Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of follicular thyroid gland carcinoma, following the rules of the TNM AJCC v8 classification system.


name: Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1a, M0); (T1, N1b, M0); (T2, N1b, M0); (T3, N1b, M0); (T4a, N1b, M0).  T4a: Moderately advanced local disease.  Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve.  T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues).  T4b: Very advanced disease.  Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels.  N0: No regional lymph node metastasis.  N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes).  N1b: Metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII). M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Supraglottis: Moderately advanced local disease.  Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus).  Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  Subglottis: Moderately advanced local disease.  Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  T4b: Supraglottis, Glottis, and Subglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


name: Recurrent Thyroid Gland Follicular Carcinoma

description: The reemergence of thyroid gland follicular carcinoma after a period of remission.


name: Clear Cell Variant Thyroid Gland Papillary Carcinoma

description: A morphologic variant of papillary carcinoma of the thyroid gland characterized by the predominance of malignant follicular clear cells.  These cells have the nuclear features that characterize the papillary carcinomas of the thyroid gland.


name: thyroid gland cribriform morular carcinoma

description: A thyroid gland carcinoma characterized by the presence of cribriform, trabecular, follicular, papillary, and solid growth patterns and squamoid morulae formation. It may occur with familial adenomatous polyposis or sporadically.


Oropharyngeal cancer recurrent

description: The reemergence of oropharyngeal carcinoma after a period of remission.


name: Recurrent Poorly Differentiated Thyroid Gland Carcinoma

description: The reemergence of poorly differentiated thyroid gland carcinoma after a period of remission.


Advanced Thyroid Gland Carcinoma

description: Thyroid gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Oropharyngeal Undifferentiated Carcinoma

description: Oropharyngeal undifferentiated carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Locally Advanced Differentiated Thyroid Gland Carcinoma

description: Differentiated thyroid gland carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IVC Oropharyngeal Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of HPV-mediated (p16-positive) oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


name: Hypopharyngeal Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of hypopharyngeal carcinoma according to the American Joint Committee on Cancer, 7th edition.


name: Stage I Differentiated Thyroid Gland Carcinoma AJCC v8

description: Stage I includes: Under 55 years: Any T, Any N, M0. 55 years and older: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IVB Thyroid Gland Papillary Carcinoma AJCC v8

description: Stage IVB includes: 55 years and older: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage IVC Nasopharyngeal Carcinoma AJCC v7


name: thyroid gland mixed medullary and follicular cell-derived carcinoma

description: A primary carcinoma of the thyroid gland containing a medullary carcinoma component that is immunohistochemically positive for calcitonin, and follicular cell-derived carcinoma component that is immunohistochemically positive for thyroglobulin.


Advanced Pharyngeal Carcinoma

description: Pharyngeal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage II Thyroid Gland Papillary Carcinoma 55 Years and Older AJCC v8

description: Stage II includes: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Metastatic Squamous Cell Carcinoma of the Nasopharynx

description: A squamous cell carcinoma of the nasopharynx which has spread from the original site of growth to another anatomic site.


name: undifferentiated carcinoma of nasopharynx

description: A undifferentiated carcinoma that involves the nasopharynx.


Stage III Laryngeal Cancer AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Supraglottis: Tumor is limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid cartilage. Glottis: Tumor is limited to the larynx with vocal cord fixation and /or invades the paraglottic space, and/or inner cortex of the thyroid cartilage. Subglottis: Tumor is limited to the larynx with vocal cord fixation and/or invades the paraglottic space and/or inner cortex of the thyroid cartilage. T1: Supraglottis: Tumor is limited to one subsite of supraglottis with normal vocal cord mobility. Glottis: Tumor is limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility. Subglottis: Tumor is limited to the subglottis. T2: Supraglottis: Tumor invades the mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of the tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx. Glottis: Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility. Subglottis: Tumor extends to vocal cord(s) with normal or impaired mobility. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


name: Thyroid Gland Mixed Medullary and Papillary Carcinoma

description: A primary carcinoma of the thyroid gland containing a medullary carcinoma component that is immunohistochemically positive for calcitonin, and papillary carcinoma component that is immunohistochemically positive for thyroglobulin.


Nasopharyngeal Neuroendocrine Carcinoma

description: An extremely rare neuroendocrine carcinoma that arises from the nasopharynx.


Nasopharyngeal Papillary Adenocarcinoma

description: A low-grade exophytic adenocarcinoma with papillary growth that arises from the epithelium of the nasopharynx. If it is completely removed, the prognosis is excellent.


Laryngeal Adenosquamous Carcinoma

description: A rare, aggressive carcinoma that arises from the larynx.  It is characterized by the presence of squamous cell carcinoma and adenocarcinoma components.  Hoarseness, sore throat, and dysphagia are the presenting symptoms.


name: Stage III Oropharyngeal Carcinoma AJCC v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IV Hypopharyngeal Carcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (Any T, N3, M0); (T4b, Any N, M0); IVC: (Any T, Any N, M1). T4a: Moderately advanced local disease. Tumor invades thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue. Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat. T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or smaller in greatest dimension. T2: Tumor invading more than one subsite of hypopharynx or an adjacent site, or measuring more than 2 cm but not more than 4 cm in greatest dimension without fixation of hemilarynx. T3: Tumor larger than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus. T4b: Very advanced local disease. Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures.  N0: No regional lymph node metastasis. N1: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (-). N2: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). N3: Tumor with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


supraglottis verrucous carcinoma

description: An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the supraglottic area of the larynx.


name: Follicular-Derived Thyroid Gland Carcinoma, High Grade

description: A thyroid gland carcinoma that arises from follicular cells and is characterized by the presence of high mitotic activity and necrotic changes in the absence of anaplastic histological features. This category includes poorly differentiated thyroid gland carcinoma and differentiated high-grade thyroid gland carcinoma.


name: Stage IV Thyroid Gland Medullary Carcinoma AJCC v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1a, M0); (T1, N1b, M0); (T2, N1b, M0); (T3, N1b, M0); (T4a, N1b, M0); IVB (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: Moderately advanced local disease.  Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve.  T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues).  T4b: Very advanced disease.  Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels.  N0: No regional lymph node metastasis.  N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes).  N1b: Metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII). M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Stage III Hypopharyngeal Carcinoma AJCC v6

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor more than 4 cm in greatest dimension or with fixation of hemilarynx.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.)


name: Stage IVA Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v7

description: Stage IVA includes: T4a, Any N, M0.  T4a: Intrathyroidal anaplastic carcinoma. M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Moderately advanced local disease. Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible. Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of the larynx. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis. N0: No regional lymph node metastasis. N1: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IV Oropharyngeal Carcinoma AJCC v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N, M1). T4a: Tumor with moderately advanced local disease.  Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible.  Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  T4b: Tumor with very advanced local disease.  Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Tumor with metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


name: Stage II Thyroid Gland Papillary Carcinoma AJCC v8

description: Stage II includes: Under 55 years: Any T, Any N, M1; 55 years and older: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage II Differentiated Thyroid Gland Carcinoma 55 Years and Older AJCC v8

description: Stage II includes: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


tonsil carcinoma

description: A carcinoma that involves the tonsil.


name: Squamous cell carcinoma of piriform sinus

description: A squamous cell carcinoma that arises from the pyriform sinus.  Patients usually present with advanced stage disease and the prognosis is poor.


Stage IVB Laryngeal Cancer AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Supraglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Glottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Subglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Nasopharyngeal lymphoepithelioma stage IV

description: Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3, M0); IVC (Any T, Any N, M1). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa.  Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho.  It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder.  This would include caudal portions of levels IV and VB.  All cases with lymph nodes (whole or part) in the fossa are considered N3b.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


name: Stage IVA Laryngeal Verrucous Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Supraglottis: Moderately advanced local disease.  Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). Subglottis: Moderately advanced local disease.  Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Parathyroid Gland Carcinoma

description: The reemergence of parathyroid gland carcinoma after a period of remission.


name: Stage IVA Thyroid Gland Follicular Carcinoma AJCC v8

description: Stage IVA includes: 55 years and older: T4b, Any N, M0. T4b: Gross extrathyroidal extension invading prevertebral fascia or encasing the carotid artery or mediastinal vessels from a tumor of any size. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Hypopharyngeal squamous cell carcinoma stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Oropharyngeal squamous cell carcinoma stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


carcinoma of pharynx

description: A carcinoma that involves the pharynx.


name: Recurrent Thyroid Gland Oncocytic Carcinoma

description: The reemergence of thyroid gland oncocytic carcinoma after a period of remission.


name: Stage I Thyroid Gland Follicular Carcinoma AJCC v7

description: Stage I includes: Under 45 years: Any T, Any N, M0.  45 years and older: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M0: No evidence of distant metastasis. (from AJCC 7th Ed.)


subglottis carcinoma

description: A carcinoma of the larynx that arises from the subglottic area.


name: Nasopharyngeal lymphoepithelioma stage III

description: Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor.  T3: Nasopharyngeal cancer with tumor involving bony structures of skull base and/or paranasal sinuses.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)


name: Thyroid Gland Follicular Carcinoma, Encapsulated Angioinvasive

description: An encapsulated follicular carcinoma of the thyroid gland which shows angioinvasion.


name: Stage I Laryngeal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: (Supraglottis) Tumor limited to one subsite of supraglottis with normal vocal cord mobility. (Glottis) Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility.  (Subglottis) Tumor limited to the subglottis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


carcinoma in situ of oropharynx

description: A in situ carcinoma that involves the oropharynx.


name: Stage I Laryngeal Verrucous Carcinoma AJCC v6 and v7


name: Metastatic Thyroid Gland Papillary Carcinoma

description: A papillary carcinoma that arises from the thyroid gland and has metastasized to another anatomic site.


Stage IVB Pharyngeal Carcinoma

description: Stage IVB carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


name: Unresectable Poorly Differentiated Thyroid Gland Carcinoma

description: Poorly differentiated thyroid gland carcinoma that is not amenable to surgical resection.


name: Stage II Thyroid Gland Papillary Carcinoma Under 55 Years AJCC v8

description: Stage II includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


Stage I Nasopharyngeal Carcinoma

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the nasopharynx. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Stage I Thyroid Gland Papillary Carcinoma AJCC v7


name: Laryngeal squamous cell carcinoma recurrent

description: The reemergence of squamous cell carcinoma of the larynx after a period of remission.


Soft Palate Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the soft palate.  It usually presents as an ulcerated or fungating mass.


name: Stage IV Thyroid Gland Papillary Carcinoma AJCC v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1a, M0); (T1, N1b, M0); (T2, N1b, M0); (T3, N1b, M0); (T4a, N1b, M0); IVB (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: Moderately advanced local disease.  Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve.  T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues).  T4b: Very advanced disease.  Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels.  N0: No regional lymph node metastasis.  N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes).  N1b: Metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII).  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


oropharynx squamous cell carcinoma

description: A squamous cell carcinoma that involves the oropharynx.


name: Stage IVC Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


Oropharyngeal Basaloid Carcinoma

description: A high-grade variant of squamous cell carcinoma that arises from the oropharynx. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.