Stage IV Prostate Cancer AJCC v8

description: Stage IV includes: IVA: Any T, N1, M0, PSA: Any, Grade Group: Any; IVB: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. M1: Prostate cancer with distant metastasis. (AJCC 8th ed.)


name: Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Monoclonal Paraproteinemia Present in Lower than Myeloma Levels

description: An indication that the detected amount of monocolonal paraproteinemia in a sample is lower than the range of levels that are associated with myeloma.


name: Human immunodeficiency virus leukoencephalopathy

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Childhood Kidney Disorder

description: A kidney disorder that appears during childhood.


name: Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Hyperglycemia, CTCAE

description: Change in daily management from baseline for a diabetic; oral antiglycemic agent initiated; workup for diabetes


Grade 5 Anal Hemorrhage, CTCAE

description: Death


name: Grade 1 Thrombotic Microangiopathy, CTCAE


name: Grade 4 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Phrenic Nerve Dysfunction, CTCAE


Emotional problems

description: A perceived issue with a person's emotional wellbeing.


Grade 4 Rectal Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 2 Concentration Impairment, CTCAE

description: Moderate impairment in attention or decreased level of concentration; limiting instrumental ADL


Grade 2 Bile Duct Stenosis, CTCAE

description: Symptomatic; altered GI function; IV fluids indicated <24 hrs


name: Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Clear cell tumor

description: A purely morphologic term that describes a neoplasm in which all or the majority of the neoplastic cells have a clear cytoplasm, when examined under light microscopy, using the conventional staining method (H-E). This term does not provide any information about the nature of the neoplasm (benign or malignant), cell of origin (e.g. epithelial versus mesenchymal versus hematopoietic), or prognosis. Further examination using special stains and/or immunohistochemistry is required to appropriately classify this tumor.


High-CSD Melanoma

description: A cutaneous melanoma that develops on sun-exposed sites with a high degree of cumulative sun damage (CSD).


Recurrent Malignant Endocrine Neoplasm

description: Reemergence of a malignant endocrine neoplasm after a period of remission.


name: Anemia due to disorders of nucleotide metabolism

description: A group of hemolytic anemias that result from either the deficiency or overproduction of several enzymes involved in metabolizing nucleotides.


Hyperlipidemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of lipids in blood.


name: Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Rectal Fissure, CTCAE

description: Invasive intervention indicated


Metastatic Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


name: Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage

description: A term that refers to the staging of adrenal gland pheochromocytoma and sympathetic paraganglioma, following the rules of the TNM AJCC v8 classification system. Parasympathetic paragangliomas are not staged because they are largely benign. This staging system does not apply to neuroendocrine tumors of the pancreas (are staged according to the classification for neuroendocrine tumors of the pancreas) and carotid body tumors (not staged). (from AJCC 8th Ed.)


name: Abnormal Phenolsulfonphthalein Test Result

description: A laboratory test result indicating other than normal parameters after a phenolsulfonphthaliein test.


Recurrent Retinoblastoma

description: The reemergence of retinoblastoma after a period of remission.


Radiation injury of bone marrow

description: Radiation injury of the hematopoietic system.


name: Grade 4 Cranial Nerve X Neuropathy, CTCAE


Invasive Malignant Neoplasm

description: Cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues.


name: Grade 4 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Chronic Myelomonocytic Leukemia with Eosinophilia

description: A chronic myelomonocytic leukemia characterized by a peripheral blood eosinophil count of equal or greater than 1.5x10E9/L, and absence of PDGFRA or PDGFRB gene abnormalities.


name: Advanced Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Esophageal Obstruction, CTCAE

description: Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 4 Ovarian Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage IIIB Fallopian Tube Cancer AJCC v8

description: Stage IIIB includes: T3b, N0/N1, M0. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 1 Ileum Intra-Operative Injury, CTCAE


name: Ampulla of Vater Invasive Papillary Adenocarcinoma

description: An invasive adenocarcinoma that arises from an exophytic papillary neoplasm of the ampulla of Vater.


name: Grade 5 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IVC Appendix Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1b, Any G.  M1b: Nonperitoneal metastasis.  (AJCC 7th ed.)


name: Grade 4 Lower Gastrointestinal Hemorrhage NOS, CTCAE


name: Unresectable Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that is not amenable to surgical resection.


name: Grade 4 Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Myelitis, CTCAE

description: Moderate weakness or sensory loss; limiting instrumental ADL


name: Grade 3 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Repeat Expansion Disease

description: A class of genetic diseases that occur when microsatellite repeats expand beyond a threshold length.


name: Anal Adenocarcinoma within Anorectal Fistula

description: An anal adenocarcinoma arising from the lining of an anorectal fistulous tract.  The overlying anal mucosa does not show evidence of neoplastic changes.  Some cases are associated with Crohn disease.


name: idiopathic normal pressure hydrocephalus

description: A disorder characterized by hydrocephalus in the setting of normal cerebrospinal fluid pressure, gait apraxia, impaired cognition and urinary urgency or incontinence.


name: Hemorrhage and Bleeding Associated with Surgery, CTCAE


Stage IA Cutaneous Melanoma AJCC v7

description: Stage IA includes: T1a, N0, M0.  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and with mitosis less than 1/mm2.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Phantom Pain, CTCAE

description: Severe pain; limiting self care ADL


Grade 3 Abdominal Distension, CTCAE

description: Severe discomfort; limiting self care ADL


name: Stage IA Fallopian Tube Cancer AJCC v6 and v7

description: Stage IA includes: T1a, N0, M0. T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Benign Infratentorial Neoplasms

description: A neoplasm that arises from the infratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 4 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Acute Lymphoblastic Leukemia by Gene Expression Profile

description: Gene expression-based patient cluster groups in acute lymphoblastic leukemia.


name: Grade 1 Vagina Stricture or Stenosis, CTCAE


Grade 5 Peripheral Ischemia, CTCAE

description: Death


name: Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Alkalosis, CTCAE

description: Death


Composite paraganglioma

description: A neoplasm that combines morphologic characteristics of paraganglioma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


name: Grade 2 Glomerular Filtration Rate, CTCAE


Recurrent pyogenic cholangitis

description: A recurrent form of cholangitis that is characterized by intrabiliary pigment stone formation, biliary tree stricture and obstruction, and recurrent bouts of cholangitis. There is an association with biliary parasitosis, but evidence supporting these infections in the pathogenesis of recurrent pyogenic cholangitis is inconclusive. The most common causes of death are sepsis, liver failure, or complications from cirrhosis. Patients are also at increased risk of cholangiocarcinoma.


Grade 3 Pharyngeal Stenosis, CTCAE

description: Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)


name: Grade 3 Lower Extremity Vein Intra-Operative Injury, CTCAE


name: Stage II Ampulla of Vater Cancer AJCC v8

description: Stage II includes: IIA: T3a, N0, M0; IIB: T3b, N0, M0. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Germinative Follicular Epithelium Neoplasm

description: A neoplasm involving the germinative follicular epithelium.


name: Infectious disease of genitourinary system

description: An acute or chronic infectious process affecting any part of the genitourinary system.


name: Grade 1 Urinary Electrolyte Wasting, CTCAE


name: Myeloid/Lymphoid Neoplasms with ETV6-ABL1

description: Hematologic neoplasms characterized by t(9;12)(q34.1;p13.2) that results in ETV6-ABL1 gene fusion. They have clinicopathological features of chronic myeloid leukemia with frequent eosinophilia.


Grade 4 Pancreatic Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Mixed Failure to Thrive

description: Failure to thrive due to both organic and non-organic causes.


Dysgeusia, CTCAE

description: A disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell.


name: Grade 1 Urinary Tract NOS Intra-Operative Injury, CTCAE


PSA Level Finding

description: A finding that indicates the amount of prostate specific antigen in a sample.


Wound Complication, CTCAE

description: A finding of development of a new problem at the site of an existing wound.


name: Grade 5 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Fever Without Neutropenia, CTCAE


Grade 1 Dry Skin, CTCAE

description: Covering <10% BSA and no associated erythema or pruritus


name: Childhood Malignant Digestive System Neoplasm

description: A malignant neoplasm that affects any part of the digestive system and occurs during childhood.


name: Stage IV Lentigo Maligna Melanoma AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


name: Grade 1 Other Growth and Development, CTCAE


Pediatric Infectious Disorder

description: An infectious disorder that occurs during infancy, childhood, or adolescence.


Hypothalamic Cancer

description: A primary or metastatic malignant neoplasm that affects the hypothalamus.


Hypergranular promyelocytic leukemia

description: Acute Promyelocytic leukemia characterized by the presence of hypergranular promyelocytes and characteristic cells that contain bundles of Auer rods.


Grade 2 Oropharyngeal Pain, CTCAE

description: Moderate pain; altered oral intake; non-narcotics initiated; topical analgesics initiated


name: Grade 4 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Cholesterol High, CTCAE

description: >500 mg/dL; >12.92 mmol/L


Grade 1 Pulmonary Valve Disease, CTCAE

description: Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


name: Non-Hodgkin's Lymphoma, Lymphoblastic (WF)


name: Grade 3 Intraoperative Hepatobiliary Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 5 Cystitis Noninfective, CTCAE

description: Death


Solder Fume Exposure

description: Environmental, occupational, or consumer-based exposure to vaporized materials during the soldering process.


name: Grade 4 Prolapse of Gastrointestinal Stoma, CTCAE


Stage IVB Gallbladder Cancer AJCC v8

description: Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1). N2: Metastases to four or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Bladder Small Cell Neuroendocrine Carcinoma

description: A bladder small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Primary cutaneous CD30 antigen positive T-cell lymphoproliferative disorder

description: A spectrum of lymphoproliferative disorders characterized by CD30 (Ki-1)-positive cutaneous T-cell infiltrates. The two ends of the spectrum include lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma.


name: Grade 2 Esophagus Intra-Operative Injury, CTCAE


Dyspnea with Moderate Physical Activity

description: Dyspnea experienced during moderate exertion.


name: Localized Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma of bone that occurs in childhood and has not spread to other anatomic sites.


Grade 3 Hematuria, CTCAE

description: Gross hematuria; transfusion, IV medications, or hospitalization indicated; elective invasive intervention indicated; limiting self care ADL


Grade 1 Fall, CTCAE

description: Minor with no resultant injuries; intervention not indicated


name: Locally Advanced Pancreatic Neuroendocrine Carcinoma

description: A pancreatic neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Oligodendroglioma

description: An oligodendroglioma that is not amenable to surgical resection.


name: Grade 2 Nodal or Junctional Rhythm, CTCAE


name: Grade 3 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Stage IA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Yolk Sac Tumor with Somatic-Type Malignancy

description: A yolk sac tumor that is characterized by morphologic transformation to somatic-type malignancy. The somatic-type malignant component most often is sarcomatous or carcinomatous.


name: Grade 4 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


name: Clear Cell Tumor with Melanocytic Differentiation and MITF-CREM Translocation

description: A MITF pathway-activated melanocytic tumor characterized by a cytogenetic translocation between MITF and CREM genes that results in MITF-CREM gene fusion. It presents as a single non-pigmented cutaneous nodule in the distal extremities. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis without an intraepidermal component. Extension in the subcutaneous tissue is frequently seen. The neoplastic cells exhibit atypical features, including nuclear enlargement and hyperchromasia, irregular nuclear borders, and enlarged nucleolus. Mitotic activity is prominent. The biologic potential of this tumor is unknown.


name: Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intraepithelial Melanocytic Hyperplasia

description: A hyperplasia of the intraepithelial melanocytes.


name: Grade 1 Stomach Stricture or Stenosis, CTCAE


name: FIGO Stage IVC Gestational Trophoblastic Tumor


Childhood Gastric Carcinoma

description: A rare carcinoma of the stomach that occurs during childhood.


name: Phlebitis Including Superficial Thrombosis, CTCAE


name: Grade 2 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Superior Vena Cava Syndrome, CTCAE

description: Severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting)


Stage IV Gallbladder Cancer AJCC v6

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


name: Stage y-I Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor limited to kidney and completely resected. Renal capsule may be infiltrated by tumor, but tumor does not reach the outer surface. Tumor may protrude or bulge into the pelvic system or ureter but does not infiltrate. Vessel of renal sinus not involved. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 3 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Native valve endocarditis

description: Endocarditis affecting a native valve of the heart.


Benign germ cell neoplasm

description: A germ cell tumor without evidence of atypia and metastatic potential.


Pleural Infection

description: An infectious process affecting the pleura.


Stage II Uterine Corpus Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II.  N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Esophageal Hodgkin Lymphoma

description: A very rare Hodgkin lymphoma that arises from the esophagus.


Refractory Vaginal Carcinoma

description: Vaginal carcinoma that does not respond to treatment.


name: Grade 4 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 2 Hypoxia, CTCAE

description: Decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen


Verumontanum Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. Crystalloids and intraluminal mucin are usually absent, but; intraluminal corpora amylacea are often present. The lining epithelium typically consists of bland cuboidal to columnar luminal cells with underlying basal cells.


name: Unresectable Fallopian Tube Endometrioid Adenocarcinoma

description: Fallopian tube endometrioid adenocarcinoma that is not amenable to surgical resection.


name: Grade 2 Genitourinary Stoma Prolapse, CTCAE


name: Acute Myeloid Leukemia with t(1;17)(q42.3;q21.2); IRF2BP2-RARA

description: Acute myeloid leukemia with variant RARA rearrangement associated with t(1;17)(q42.3;q21.2) resulting in IRF2BP2-RARA fusion protein expression.


Salivary Gland Infection, CTCAE

description: A disorder characterized by an infectious process involving the salivary gland.


name: Grade 3 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Pelvis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Vascular Access Graft Failure

description: Failure to achieve vascular access due to damage of the graft that was created for this purpose.


name: Grade 1 Muscle Weakness Right-Sided, CTCAE

description: Symptomatic; perceived by patient but not evident on physical exam


Anal Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the anal region.


name: Grade 1 Upper Extremity Artery Injury, CTCAE


Retinal Vascular Disorder, CTCAE

description: A disorder characterized by pathological retinal blood vessels that adversely affects vision.


name: Recurrent Adult Diffuse Large Cell Lymphoma

description: The reemergence of adult diffuse large cell lymphoma after a period of remission.


name: Grade 1 Transient Ischemic Attacks, CTCAE

description: Mild neurologic deficit with or without imaging confirmation


Benign Anal Granular Cell Tumor

description: A granular cell tumor that arises from the anus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Vision Decreased, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


Acquired Facial Nerve Palsy

description: A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve that has occurred after birth.


Grade 5 Pulmonary Edema, CTCAE

description: Death


Unresectable Fibrosarcoma

description: A fibrosarcoma that is not amenable to surgical resection.


Central line complication

description: A problem with a central venous access catheter or site of insertion.


name: Grade 4 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Urinary Tract Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the urinary tract.


name: Beta Thalassemia Plus Structural Variants

description: A heterozygous state in which a person has a mutation in a beta globin allele causing beta thalassemia, together with other structural variants in the other allele.


Esthesioneurocytoma

description: A rare benign neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity. Microscopically, it is characterized by the absence of malignant characteristics and the absence of rosettes formation.


Small Intestinal Mucositis, CTCAE

description: A disorder characterized by ulceration or inflammation of the mucous membrane of the small intestine.


Recurrent Primary Amyloidosis

description: The reemergence of primary amyloidosis after a period of remission.


Metastatic transitional cell carcinoma

description: A carcinoma that arises from transitional cells and has spread from its original site of growth to another anatomic site.


name: Grade 3 Radiation Recall Reaction (Dermatologic), CTCAE

description: Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion


name: Grade 2 Esophageal Varices Hemorrhage, CTCAE

description: Self-limited; intervention not indicated


Asystole, CTCAE 5.0

description: A disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart.


Grade 3 Apnea, CTCAE

description: Present; medical intervention indicated


Neonatal Gastrointestinal Bleeding, AE

description: An adverse event in a newborn characterized by hemorrhage originating at any site located within the gastrointestinal tract.


name: Localized Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

description: Tumor confined to the area of origin including the regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 2 Neuroendocrine ADH Secretion Abnormality, CTCAE


name: Grade 2 Blood Antidiuretic Hormone Abnormal, CTCAE

description: Symptomatic; medical intervention indicated


Solvent Exposure

description: Environmental, occupational, or consumer-based exposure to volatiles associated with production, handling and use of chemical solvents.


Non-Neoplastic Peritoneal Disorder

description: A non-neoplastic disorder that affects the peritoneum. Representative examples include peritonitis and panniculitis.


Inherited neuropathies

description: A hereditary disorder that affects the sensory and/or motor nerves or the autonomic nerves.


name: Grade 2 Thoracic Duct Intra-Operative Injury, CTCAE


name: Skin Reaction Secondary to Radiation Therapy


name: Intracranial Laceration Related to Birth

description: Tearing of the cerebral or cerebellar parenchyma or vessels of a newborn infant due to forces occurring during labor and delivery.


Grade 1 Hypernatremia, CTCAE

description: >ULN-150 mmol/L


name: Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8

description: Stage IIIA includes: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Grade 1 Pituitary Intra-Operative Injury, CTCAE


name: Grade 3 Pancreatic Enzymes Decreased, CTCAE

description: Sequelae of absorption deficiency


Grade 3 Esophagitis, CTCAE

description: Severely altered eating/swallowing; tube feeding, TPN, or hospitalization indicated


Fracture, CTCAE

description: A finding of traumatic injury to the bone in which the continuity of the bone is broken.


name: Grade 1 Intraoperative Musculoskeletal Injury, CTCAE

description: Primary repair of injured organ/structure indicated


Tumor Mass of the Extremity

description: A mass-forming benign or malignant neoplasm that affects a limb of the body.


Esophageal Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The Ki-67 index is higher than 20%.


name: Grade 2 Tendon Intra-Operative Injury, CTCAE


name: Grade 1 Female Genital Tract Fistula, CTCAE


Grade 1 Pleural Hemorrhage, CTCAE

description: Asymptomatic; mild hemorrhage confirmed by thoracentesis


Advanced Malignant Germ Cell Tumor

description: A malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Endometrial Carcinoma

description: Endometrial carcinoma that is not amenable to surgical resection.


name: intraductal papillary-mucinous neoplasm of pancreas with moderate dysplasia

description: A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit nuclear stratification, loss of polarity, and crowding.  There is moderate nuclear hyperchromasia.


Aplastic anemia due to infection

description: Aplastic anemia caused by an infection.


Grade 3 Keratitis, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); corneal ulcer; limiting self care ADL


Otitis Media, CTCAE

description: A disorder characterized by an infectious process involving the middle ear.


Grade 5 Neonatal Fever, AE

description: A febrile adverse event in a newborn which results in death.


name: Schizoaffective disorder, depressive type

description: Schizoaffective disorder with episodes of depression only.


Grade 2 Rectal Obstruction, CTCAE

description: Symptomatic; altered GI function; limiting instrumental ADL


name: Esophageal High Grade Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa.  It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia).  (WHO, 2000)


Grade 4 Vasculitis, CTCAE

description: Life-threatening consequences; evidence of peripheral or visceral ischemia; urgent intervention indicated


name: Advanced Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIB Fallopian Tube Cancer AJCC v7

description: Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Ileal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 4 CNS Cerebrovascular Ischemia, CTCAE


name: Pathologic Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0, G1); (T1a, N0, M0, GX); IB: (T1a, N0, M0, G2); (T1b, N0, M0, G1-2); (T1b, N0, M0, GX); IC: (T1, N0, M0, G3); (T2, N0, M0, G1-2). T1a: Tumor invades the lamina propria or muscularis mucosae. T1b: Tumor invades the submucosa. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. G2: Moderately differentiated. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Neoplasm by Special Category

description: A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution.


Grade 3 Laryngeal Edema, CTCAE

description: Stridor; respiratory distress; hospitalization indicated


name: Grade 5 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Upper Gastrointestinal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach).


name: Grade 3 Superior Vena Cava Vein Injury, CTCAE


Vomiting, CTCAE

description: A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.


name: Grade 2 International Normalized Ratio of Prothrombin Time, CTCAE


Grade 4 Colonic Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 2 Hypoalbuminemia, CTCAE

description: <3-2 g/dL; <30-20 g/L


Localized Gastric Carcinoma

description: A carcinoma that arises from the stomach and has not spread to other anatomic sites.


Uterine Ligament Wolffian Tumor

description: An epithelial neoplasm of Wolffian (mesonephric) origin arising from a uterine ligament. Most tumors behave in a benign fashion.


name: Grade 5 Colon Infection with Unknown Absolute Neutrophil Count, CTCAE


Retrobulbar Hemorrhage

description: Bleeding in the orbital cavity that results in compression of orbital structures, resulting in ischemia of the optic nerve, and possible loss of vision.


Grade 1 Aspiration, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Transient Hyperinsulinism

description: Hyperinsulinism that resolves spontaneously. This is the most common cause of neonatal hypoglycemia.


Recurrent Malignant Solid Neoplasm

description: A malignant solid neoplasm that has recurred after a period of remission.


Chronic Decubitus

description: A longstanding lesion caused by death of tissue due to external pressure.


Sinusoidal hemangioma

description: A rare hemangioma occurring mainly in middle-aged adults. The most common location is in the trunk. The lesions are small, asymptomatic, and bluish. They are composed of irregular, dilated, congested thin-walled vascular channels with scant smooth muscle in a sinusoidal or sieve-like pattern. (WHO 2018)


Stage IB Cervical Cancer AJCC v9

description: Stage IB includes: T1b, N0, M0. T1b: Tumor with measured deepest invasion more than 5 mm (greater than FIGO stage IA); lesion limited to the cervix uteri with size measured by maximum tumor diameter. Note: The involvement of vascular/lymphatic spaces should not change the staging. The lateral extent of the lesion is no longer considered. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Febrile Neutropenia without Clinically or Microbiologically Documented Infection with Absolute Neutrophil Count Less Than 1 X 10e9 per Liter and Temperature Greater Than or Equal to 38 Point 5 Degrees Celsius, CTCAE


Grade 3 Atrial Fibrillation, CTCAE

description: Symptomatic, urgent intervention indicated; device (e.g., pacemaker); ablation; new onset


name: Grade 1 Cervical Spine Range of Motion, CTCAE


name: General Disorders and Administration Site Conditions - Other, Specify, CTCAE


Verruca Plana

description: A wart characterized by the presence of flat-topped cutaneous papules. It is caused by human papillomavirus. It most commonly affects children and usually arises on the face, hands, and shins.


name: Stage IVB Cervical Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Stage IIIC Gastric Cancer AJCC v7

description: Stage IIIC includes: (T4b, N2, M0); (T4b, N3, M0); (T4a, N3, M0).  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Killing Pain

description: A sensation of extreme discomfort and anguish that is perceived as severe enough to cause one's death.


name: Grade 2 Stoma Pulmonary Hemorrhage, CTCAE


name: Grade 2 Other Musculoskeletal and Soft Tissue, CTCAE


name: Metastatic Pancreatic Ductal Adenocarcinoma

description: An adenocarcinoma that arises from the exocrine pancreatic ducts and has metastasized to other anatomic sites.


Grade 1 Bullous Dermatitis, CTCAE

description: Asymptomatic; blisters covering <10% BSA


name: Grade 2 Glossopharyngeal Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


CTCAE v4 Grade 2

description: An adverse event for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated; or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).


name: Hematologic Malignancy-Associated Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the skin in a patient with a history of hematologic malignancy, usually non-Hodgkin lymphoma or chronic lymphocytic leukemia.


Marginal ulcer

description: An ulcer that develops in the jejunal mucosa close to the anastomosis site following a gastroenterostomy procedure.


name: Metastatic Carcinoma to the Uterine Cervix

description: A carcinoma that has spread to the cervix from another anatomic site.


Conjunctival foreign body

description: External material in or on the conjunctiva.


Gum Infection, CTCAE

description: A disorder characterized by an infectious process involving the gums.


description: A high grade poorly differentiated carcinoma arising from the digestive system.  It is composed of small or large neoplastic cells that express immunohistochemical evidence of neuroendocrine differentiation.  There is marked nuclear atypia, necrosis, and more than 20 mitoses per 10 HPF.


Low Glutathione Level

description: An indication that a lower than average level of glutathione was detected in a sample.


name: Grade 2 Intraoperative Endocrine Injury, CTCAE

description: Partial resection of injured organ/structure indicated


Nevus of Female Genitalia

description: A nevus that arises from the female genital organs. This category includes congenital nevus, acquired nevus, dysplastic nevus, blue nevus, and atypical melanocytic nevus of the genital type.


Increased Porphyrin

description: Increase in the amount of porphyrin.


name: Metabolic or Respiratory Acidosis, CTCAE


Grade 5 Hypertriglyceridemia, CTCAE

description: Death


name: Acute Myocardial Injury with Type I Myocardial Infarction Related to COVID-19

description: Acute myocardial injury with clinical presentation suggestive of type I myocardial infarction with detection of a rise or fall of cardiac troponin values with at least one value above the 99th percentile upper reference limit and with at least 1 of the following: 1. Symptoms of acute myocardial ischemia; 2. New ischemic ECG changes; 3. Development of pathological Q waves; 4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5. Identification of a coronary thrombus by angiography including intracoronary imaging or by autopsy, occurring in a patient with probable or confirmed acute COVID-19.


description: Intraepithelial neoplasia of the penis or vulva. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present.


name: Grade 3 Upper Extremity Artery Intra-Operative Injury, CTCAE


Ectromelia

description: A congenital defect characterized by the absence or hypoplasia of one or more extremities.


name: Grade 3 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 5 Pancreas Infection, CTCAE

description: Death


name: Grade 5 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Bacterial Prostatitis

description: An acute infection of the prostate gland caused by bacteria, most often Escherichia coli, Proteus mirabilis, Klebsiella, and Pseudomonas aeruginosa. Signs and symptoms include fever, lower back pain, urinary frequency, and painful urination.  The urinalysis reveals the presence of white cells.  Risk factors include intraprostatic ductal reflux, phimosis, urinary tract infections, and unprotected anal intercourse.


Postoperative Hemorrhage, CTCAE

description: A disorder characterized by bleeding occurring after a surgical procedure.


Grade 3 Neck Edema, CTCAE

description: Generalized neck edema (e.g., difficulty in turning neck); limiting self care ADL


Grade 5 Bile Duct Stenosis, CTCAE

description: Death


name: Stage IIIC1 Uterine Corpus Cancer AJCC v8

description: Stage IIIC1 includes: T1-T3, N1/N1mi/N1a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Breast Nipple and Areolar Deformity, CTCAE


name: Refractory Malignant Neoplasm of Multiple Primary Sites

description: Malignant neoplasm of multiple primary sites that is resistant to treatment.


name: Grade 2 Vagina Stricture or Stenosis, CTCAE


Urethral Melanoma

description: A rare melanoma that arises from the urethral mucosa.


name: Grade 3 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Anus Intra-Operative Injury, CTCAE


name: Refractory Invasive Pulmonary Aspergillosis

description: Invasive pulmonary aspergillosis that is resistant to treatment.


Skin Nodulocystic Basal Cell Carcinoma

description: A nodular basal cell carcinoma composed of solid and cystic areas.


Thoracotomy Scar

description: Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where an incision was made into the chest wall to the left or to the right of the midline.


Pharyngeal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the pharyngeal airway.


name: Grade 3 Pulmonary Fibrosis Radiographic Changes, CTCAE


name: Grade 5 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


P2 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is greater than or equal to 15 mm, 2) the calyces may be dilated centrally and peripherally, 3) or a dilated ureter is visible, 4) the parenchymal thickness and appearance is normal, and 5) the bladder is normal. Cases in which there is peripheral calyceal dilation but the APRPD is less than 15 mm are classified as UTD P2. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma

description: A rare subtype of prostate acinar adenocarcinoma that morphologically resembles high-grade prostatic intraepithelial neoplasia. It is characterized by the presence of large malignant glands lined with pseudostratified epithelium. It is graded as Gleason score 3+3=6.


name: Resectable Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that is amenable to surgical resection.


Skin Atrophy, CTCAE 5.0

description: A disorder characterized by the degeneration and thinning of the epidermis and dermis.


name: Stage I Gastric Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Cervical Mesonephric Remnants and Hyperplasia

description: The presence of embryonic remnants of mesonephric ducts in the cervix and their benign hyperplastic proliferations.


Grade 3 Uveitis, CTCAE

description: Anterior uveitis with 3+ or greater cells; intermediate posterior or pan-uveitis


Glucagonoma, malignant

description: A glucagon-producing neuroendocrine tumor arising from the alpha cells of the pancreas.  It may be associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia.  It displays vascular invasion and metastasizes to other anatomic sites.


name: Benign Osteoclastic Giant Cell-Rich Tumor of Bone

description: A giant cell tumor that arises from the bone and is characterized by the absence of local aggression and lack of metastatic potential.


Neonatal rickets

description: Rickets that usually affects premature infants. Factors that contribute to the development of neonatal rickets include calcium, phosphorus, or calciferol deficiency. It manifests with spontaneous fractures, respiratory distress, and growth developmental delays.


name: Unresectable Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that is not amenable to surgical resection.


name: Grade 2 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Recurrent Plasma Cell Neoplasm

description: The reemergence of a plasma cell neoplasm after a period of remission.


Prostate Paraganglioma

description: A paraganglioma that affects the prostate gland.


Anxiety, CTCAE 5.0

description: A disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.


name: Adenoma of the Retinal Pigment Epithelium

description: A benign neoplasm that arises from the retinal pigment epithelium. It consists of cords and tubules of variably pigmented proliferating retinal pigment epithelium cells, separated by fibrous stroma. Malignant transformation is rare. (WHO 2018)


Neonatal Herpes Simplex Infection

description: Infection in the first month of life caused by the Herpes simplex virus.


Grade 2 Esophageal Infection, CTCAE

description: Local intervention indicated (e.g., oral antibiotic, antifungal, antiviral)


name: Grade 3 Other Allergy and Immunology, CTCAE


Grade 2 Movements Involuntary, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Grade 4 Pelvis NOS Intra-Operative Injury, CTCAE


name: Low Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Grade 1 Nail Ridging, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Neuroendocrine carcinoma of the bladder

description: A malignant, high grade neuroendocrine neoplasm that arises from the bladder. This category includes small cell and large cell neuroendocrine carcinoma.


Grade 3 Urostomy Obstruction, CTCAE

description: Altered organ function (e.g., sepsis or hydronephrosis, or renal dysfunction); elective operative intervention indicated


Grade 1 Urinary Retention, CTCAE

description: Urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual


name: Grade 1 Upper Extremity Vein Intra-Operative Injury, CTCAE


Drug Resistant Epilepsy

description: Epilepsy that is refractory to treatment.


Grade 1 Bronchopulmonary Dysplasia, AE

description: An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND breathing room air at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; breathing room air by 56 days postnatal age in infants born greater than 32 weeks' gestation; breathing room air at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


name: Stage IIIC Esophageal Adenocarcinoma AJCC v7

description: Stage IIIC includes: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Recurrent WHO Grade 3 Glioma

description: The reemergence of a WHO grade III glioma after a period of remission.


Advanced Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 5 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Lacrimal Drainage System Lymphoepithelial Carcinoma

description: A rare nonkeratinizing squamous cell carcinoma that arises from the lacrimal sac or nasolacrimal duct. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


Thrombosis of abdominal aorta

description: Formation of blood clot in the lumen of the abdominal aorta. It may lead to severe abdominal pain and ischemic necrosis of the intestine.


Grade 2 Breast Infection, CTCAE

description: Local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage IIIA Cervical Cancer FIGO 2018

description: Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Facial Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the facial nerve (seventh cranial nerve).


Grade 5 Bronchopulmonary Dysplasia, AE

description: A bronchopulmonary dysplasia adverse event in a newborn which results in death.


Acquired factor IX deficiency disease

description: An acquired coagulation disorder characterized by the partial or complete absence of factor IX activity in the blood.


name: Grade 3 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Life Threatening Adverse Event

description: An adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken.


Burn, CTCAE

description: A finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment.


name: Refractory Fallopian Tube Adenocarcinoma

description: Fallopian tube adenocarcinoma that is resistant to treatment.


name: Grade 3 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 4 Pancreatic Duct Intra-Operative Injury, CTCAE


name: Recurrent Pineal Parenchymal Cell Neoplasm

description: The reemergence of pineal parenchymal cell neoplasm after a period of remission.


Vagus Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the vagus nerve (tenth cranial nerve).


name: Grade 3 Social Circumstances - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Gallbladder Pain, CTCAE

description: Mild pain


Ureteric fistula

description: An abnormal communication between the ureter and another organ or anatomic site.


name: Grade 1 Anus Intra-Operative Injury, CTCAE


Grade 4 Stridor, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Grade 2 Hepatitis B Reactivation, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Grade 4 Carbon Monoxide Diffusion Capacity, CTCAE


Grade 1 Shingles, CTCAE

description: Localized, local intervention indicated


Cardiac Enzyme Elevation

description: An increase from the normal levels of cardiac enzymes measurement.


name: Grade 2 Meninges Intra-Operative Injury, CTCAE


Broad Ligament Serous Cystadenofibroma

description: A rare serous cystadenofibroma arising from the broad ligament.


Grade 2 Colonic Obstruction, CTCAE

description: Symptomatic; altered GI function


Grade 2 Amnesia, CTCAE

description: Moderate; short term memory loss; limiting instrumental ADL


FNCLCC Sarcoma Grade 3

description: A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines.


Grade 3 Arterial Injury, CTCAE

description: Severe symptoms; limiting self care ADL; repair or revision indicated


Plexiform Spindle Cell Melanocytoma

description: A subtype of WNT-activated deep penetrating/plexiform melanocytoma (nevus). It is characterized by the proliferation of neoplastic melanocytes in the upper dermis, forming a plexiform pattern.


Grade 3 Esophageal Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


name: Male Reproductive System Precancerous Condition

description: A premalignant pathologic process arising from an organ of the male reproductive system.  It is characterized by cellular atypia and/or dysplasia but does not show morphologic evidence of stromal invasion at the time of diagnosis.  Representative examples include prostatic intraepithelial neoplasia, giant condyloma acuminatum of the penis, and penile intraepithelial neoplasia.


Grade 1 Dermatitis Radiation, CTCAE

description: Faint erythema or dry desquamation


Grade 1 Jejunal Ulcer, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hepatic Failure, CTCAE

description: A disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, alkaline phosphatase, aminotransferase, and/or prolongation of prothrombin time (INR.) Drug-induced liever injury (DILI) as defined by Hy's Law.


name: Unresectable Ampulla of Vater Adenocarcinoma

description: Adenocarcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


Metastatic Bone Sarcoma

description: Bone sarcoma that has spread from the original site of growth to another anatomic site.


name: Hyperplasia of Brunner glands of duodenum

description: A rare hyperplastic lesion of Brunner's gland in the duodenum. Although it is usually asymptomatic and discovered incidentally during upper gastrointestinal endoscopy, it may cause hemorrhage.


name: Grade 1 Testis Intra-Operative Injury, CTCAE


Grade 2 Pleural Effusion, CTCAE

description: Symptomatic; intervention indicated (e.g., diuretics or therapeutic thoracentesis)


name: Stage IVA Oral Cavity Verrucous Carcinoma


name: B-Cell Proliferation of Uncertain Malignant Potential

description: A B-cell lymphoproliferative disorder with uncertain malignant potential. The representative example of this category is lymphomatoid granulomatosis.


name: Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Vulvar Carcinoma

description: Vulvar carcinoma that does not respond to treatment.


Grade 3 Cataract, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Premature Delivery, CTCAE

description: A disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.


Grade 3 Sleep Apnea, CTCAE

description: Oxygen desaturation; associated with pulmonary hypertension; medical intervention indicated; limiting self care ADL


name: Grade 1 Bronchopulmonary Hemorrhage NOS, CTCAE


Grade 5 Lymph Leakage, CTCAE

description: Death


name: Grade 2 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


name: Grade 3 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Appendicitis, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Foreign-Body Reaction

description: An inflammatory lesion comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material.


Non-Neoplastic Musculoskeletal Disorder

description: A non-neoplastic disorder that affects muscles and bones.


name: Grade 3 Pharynx Obstruction and Stenosis, CTCAE


name: Grade 2 Blood Bilirubin Increased, CTCAE

description: >1.5-3.0 x ULN if baseline was normal; >1.5-3.0 x baseline if baseline was abnormal


lymphomatoid papulosis, type C

description: A variant of lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma.


description: Ovarian or testicular dysfunction associated with high levels of gonadotropins, that is present at birth.


name: Chronic Phase Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive

description: A phase of chronic myeloid leukemia, Philadelphia chromosome positive, BCR-ABL1 positive in which the peripheral blood smear shows leukocytosis with neutrophils in different stages of maturation, less than 2% blasts, and normal or increased platelet count. Most patients have mild anemia. The bone marrow is hypercellular due to increased numbers of neutrophils and their precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by granulocytes.


name: Recurrent Ampulla of Vater Adenocarcinoma

description: The reemergence of ampulla of Vater adenocarcinoma after a period of remission.


Maternal Weight Gain in Pregnancy

description: The last recorded maternal weight prior to birth minus the last recorded weight immediately prior to pregnancy. (reVITALize)


Congenital Cystic Hygroma

description: A congenital lymphatic malformation usually arising from the neck and characterized by cystic dilation of the lymphatic vessels.


Adenocarcinoma endometrial metastatic

description: An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


Seminal Versicle Carcinoma

description: A carcinoma that arises from the seminal vesicle.


name: Refractory Acute Myeloid Leukemia Not Otherwise Specified

description: Acute myeloid leukemia not otherwise specified that does not respond to treatment.


name: Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder

description: The reemergence of monomorphic post-transplant lymphoproliferative disorder after a period of remission.


Grade 5 Splenic Infection, CTCAE

description: Death


description: An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


Grade 1 Flatulence, CTCAE

description: Mild symptoms; intervention not indicated


Stage IB Gastric Carcinoma

description: Stage IB includes: (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Appendicitis Perforated, CTCAE

description: A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


name: Grade 3 Prolapse of Intestinal Stoma, CTCAE

description: Severe symptoms; elective operative intervention indicated; limiting self care ADL


Female urinary-genital tract fistula

description: An abnormal connection between the urinary system and the genitals in a female.


Grade 3 Lymph Node Pain, CTCAE

description: Severe pain; limiting self care ADL


description: An alveolar rhabdomyosarcoma characterized by the absence of chromosomal translocation t(1;13)(p36;q14) or t(2;13)(q35;q14) and therefore the absence of PAX7-FOXO1 or PAX3-FOXO1 gene fusion.


Primary Malignant Pelvic Neoplasm

description: A malignant neoplasm that arises from the organs and structures of the pelvis.


name: Grade 2 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Cardiac Valve Regurgitation

description: Evidence of severe retrograde blood flow through the valve(s) of the heart. (ACC)


name: FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


name: Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Gallbladder Intra-Operative Injury, CTCAE


Grade 5 Middle Ear Inflammation, CTCAE

description: Death


name: Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for mixed cellularity classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Junctional Spitz Nevus

description: A Spitz nevus characterized by the presence of a junctional melanocytic component without involvement of the dermis.


Grade 4 Gallbladder Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Breast Atrophy, CTCAE

description: Minimal asymmetry; minimal atrophy


Grade 3 Bladder Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Stage III Urethral Cancer AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. T3: For male penile urethra and female urethra: Tumor invades any of the following: corpus cavernosum, anterior vagina. For prostatic urethra: Tumor invades the periprostatic fat. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 5 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIIA Appendix Carcinoma AJCC v8

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. M0: No distant metastasis. (AJCC 8th ed.)


name: clear cell adenocarcinoma of gallbladder

description: A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells.  The cells display hyperchromic nuclei and well-defined cytoplasmic borders.


name: Nervous System Disorders - Other, Specify, CTCAE


Chronic inflammation

description: An inflammatory process characterized by the presence of lymphocytes and plasma cells and the absence of polymorphonuclear neutrophils.


Fetal Neurodevelopmental Disorder

description: A fetal affliction that has a neurological basis and manifests as a developmental disability.


Grade 3 Colonic Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


name: Grade 4 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


name: Grade 5 Neonatal Respiratory Insufficiency, AE

description: A respiratory insufficiency adverse event in a newborn which results in death.


Miserable Pain

description: A sensation of discomfort or distress that renders an individual unable to find any happiness.


Grade 3 Bullous Dermatitis, CTCAE

description: Blisters covering >30% BSA; limiting self care ADL


Stage I Vulvar Cancer

description: Stage I includes: T1, N0, M0. T1: Invasive vulvar cancer confined to the vulva or perineum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 5 Vagus Nerve Disorder, CTCAE

description: Death


name: T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta

description: An uncommon variant of T-cell large granular lymphocyte leukemia expressing the gamma-delta T-cell receptor. Approximately 60% of these cases are CD8-positive and the remainder are CD4/CD8-negative.


Unresectable Low Grade Glioma

description: Low grade glioma that is not amenable to surgical removal.


trauma to the abdomen

description: Trauma to the abdomen.


Gastrointestinal Perforation, CTCAE

description: An adverse event marked by rupture in the wall of a structure of the gastrointestinal system.


Stage III Bone Cancer AJCC v8

description: Stage III includes: T3, N0, M0, G2 or G3. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


name: Grade 2 Colon Intra-Operative Injury, CTCAE


name: Radiating Chest Pain Along Right Middle Sternal Border

description: The location of the radiating chest pain is along the right middle sternal border.


Pancreatic Enzymes Decreased

description: A laboratory test result which indicates decreased levels of pancreatic enzymes in a biologic specimen.


name: Grade 1 Upper Extremity Intra-Operative Injury, CTCAE


Nevoid Melanoma

description: A rare variant of cutaneous melanoma occurring mostly in adults in their fifth decade. Morphologically it resembles an ordinary compound or dermal nevus.


Stage I Bone Cancer AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Grade 1 Leukoencephalopathy Radiographic Findings, CTCAE


Metastatic malignant neoplasm to retina

description: A malignant neoplasm that has spread to the retina from another anatomic site.


Stage IVB Uterine Corpus Cancer AJCC v7

description: Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage IB3 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Cutaneous Mature B-Cell Neoplasm

description: A mature B-cell neoplasm that affects the skin.


name: Grade 3 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Prostate Melanoma

description: An exceptionally rare melanoma arising from the prostate gland.


name: Grade 3 Retinal Vascular Disorder, CTCAE

description: Retinal vascular disorder with neovascularization


Deep Lipoma

description: A benign well-circumscribed tumor, composed of mature adipocytes, that arises within deep soft tissues.


Craniofacial Fibrous Dysplasia

description: Fibrous dysplasia affecting the craniofacial bones.


name: Grade 5 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Muscular and Skeletal Hypoplasia, CTCAE


name: Grade 2 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cardiac granuloma

description: A granuloma located in the myocardium.


name: Stage III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Residual tumor or nonhematogenous metastases confined to abdomen. Involved abdominal nodes. Peritoneal contamination or tumor implant. Tumor spillage of any degree occurring before or during surgery. Gross residual tumor in abdomen. Biopsy of tumor (including fine-needle aspiration) prior to removal of kidney. Resection margins involved by tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 3 Pancreatic Duct Intra-Operative Injury, CTCAE


Grade 2 Proctitis, CTCAE

description: Symptomatic (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL


name: Persistent Pulmonary Hypertension of the Newborn, AE

description: An adverse event in a newborn characterized by elevated pulmonary vascular pressure in a neonate.


name: Grade 5 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Elevated DKK1

description: A finding indicating elevated concentrations of DKK1 in a sample.


Grade 5 Cecal Infection, CTCAE

description: Death


Neonatal Spell

description: Cardiorespiratory events that are characterized by variable combinations of cessation of breathing, decrease in blood oxygen saturation, and decreased heart rate.


Stage IIA Esophagus Carcinoma

description: Stage IIA includes: For squamous cell carcinoma: (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X).  For adenocarcinoma: (T2, N0, M0, G3).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


name: Grade 4 Ovary Intra-Operative Injury, CTCAE


name: Mucositis and Stomatitis by Functional and Symptomatic Classification, CTCAE


Leukopenia neonatal

description: Leukopenia that occurs in the neonatal period.


Acute lymphoblastic leukemia recurrent

description: The reemergence of acute lymphoblastic leukemia after a period of remission.


name: Unresectable Small Cell Neuroendocrine Carcinoma

description: Small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Pancreatic intraepithelial neoplasia

description: A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts.  It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter.


Esophageal Cancer by AJCC v8 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage IIIB Merkel Cell Carcinoma AJCC v7

description: Stage IIIB includes: Any T, N1b/N2, M0.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Recurrent Myeloproliferative Neoplasm

description: The reemergence of a myeloproliferative neoplasm after a period of remission.


Burn of axilla

description: A traumatic injury to the axilla resulting from exposure to caustic chemicals, extreme heat, extreme cold, or excessive radiation.


Grade 3 Hematosalpinx, CTCAE

description: Transfusion indicated; invasive intervention indicated


Bladder Infection, CTCAE

description: A disorder characterized by an infectious process involving the bladder.


Adverse Event Attributed to Disease

description: An indication that an adverse event is causally related to the natural history of disease.


Grade 2 Mucositis Oral, CTCAE

description: Moderate pain or ulcer that does not interfere with oral intake; modified diet indicated


Grade 5 Arteritis Infective, CTCAE

description: Death


name: Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Pancreatic Endocrine Glucose Intolerance, CTCAE


Sexual Aversion Disorder

description: A disorder characterized by recurrent or persistent extreme aversion to, and avoidance of, all genital contact with a sexual partner. The aversion to sexual contact is not attributable to another psychiatric disorder.


Gallbladder Tubular Carcinoid

description: A neuroendocrine tumor that arises from the gallbladder.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


name: Grade 2 Breast Volume and Hypoplasia, CTCAE


name: Grade 3 Intraoperative Gastrointestinal Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


name: Grade 2 Small Intestinal Mucositis, CTCAE

description: Symptomatic; medical intervention indicated; limiting instrumental ADL


Benign Thymoma

description: A thymoma that is completely surrounded by a capsule, without evidence of capsular invasion, infiltration of the surrounding tissues, and metastases.


name: Cutaneous Melanoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


name: Grade 4 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Proctitis, CTCAE

description: Severe symptoms; fecal urgency or stool incontinence; limiting self care ADL


Grade 3 Vaginal Perforation, CTCAE

description: Invasive intervention indicated


Childhood Osteoid Osteoma

description: An osteoid osteoma that occurs during childhood.


Grade 2 Lymph Leakage, CTCAE

description: Symptomatic; medical intervention indicated


Grade 4 Nephrotic Syndrome, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Stage IA Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


Primary Valvular Disorder

description: Heart disease that is primarily due to a valvular defect or abnormality. Valve disease that is felt to be significant but does not fulfill the definition for primary valvular heat disease is considered contributory valvular heart disease.


name: Grade 3 Genitourinary Stoma Obstruction, CTCAE


Merkel Cell Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v7 classification system.


Complication of transplanted organ, NOS

description: A disease or disorder that is associated with a transplanted organ.


Grade 2 Hallucinations, CTCAE

description: Moderate hallucinations


name: Childhood Benign Nervous System Neoplasm

description: A childhood neoplasm that arises from the nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 3 Serum Hypertriglyceridemia, CTCAE


name: Grade 5 Nervous System Disorders - Other, Specify, CTCAE

description: Death


name: Opportunistic Infection Associated with Grade 2 or Greater Lymphopenia, CTCAE


Grade 2 Pain of Skin, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Pelvic Undifferentiated High Grade Pleomorphic Sarcoma

description: Undifferentiated high grade pleomorphic sarcoma  involving the bones of the pelvis.


Marasmic kwashiorkor

description: Evidence of marasmic kwashiorkor.


name: Grade 2 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chronic Orthostatic Intolerance

description: A condition in which there is orthostatic intolerance lasting for at least three months with associated functional impairment. (ACC/AHA)


Grade 3 Scrotal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: FIGO Grade 2 Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


name: Recurrent Malignant Urinary System Neoplasm

description: Reemergence of a malignant urinary system neoplasm after a period of remission.


Grade 4 Hyperphosphatemia, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., dialysis)


name: Grade 5 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


name: Grade 1 Thyroid Stimulating Hormone Increased, CTCAE

description: TSH increased and no intervention initiated


Iron deficiency without anemia

description: Subnormal concentrations of iron resulting from low iron intake, inefficient iron absorption in the gastrointestinal tract, or increased iron loss; occurring in the absence of anemia.


name: Stage I Esophageal Adenocarcinoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Acute Myocardial Injury without Ischemia, Heart Failure, Ventricular Dysfunction, or Myocarditis Related to COVID-19

description: Acute myocardial injury, without evidence of acute ischemia, heart failure, a newly reduced left or right ventricular ejection fraction, cardiogenic shock, or myocarditis in a patient with probable or confirmed acute COVID-19.


Grade 3 Alcohol Intolerance, CTCAE

description: Severe symptoms; limiting self care ADL


Grade 3 Acidosis, CTCAE

description: pH <7.3


name: Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T2, N2, M0, Any G); (T3, N1-2, M0, Any G); (T4a, N0-1, M0, Any G). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Advanced gastric carcinoma

description: Gastric carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Refractory Dedifferentiated Liposarcoma

description: Dedifferentiated liposarcoma that does not respond to treatment.


name: Unresectable Prostate Small Cell Neuroendocrine Carcinoma

description: Prostate small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Flushing, CTCAE 5.0

description: A disorder characterized by episodic reddening of the skin, especially face, neck, or chest.


Cellulitis of pharynx

description: Cellulitis of the pharynx.


name: Grade 2 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: High grade cervical glandular intraepithelial neoplasia

description: Cervical glandular intraepithelial neoplasia characterized by the presence of severe dysplastic changes.


name: Grade 3 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Severe Adverse Event

description: An adverse event experience that requires intensive therapeutic intervention and interrupts usual daily activities.


Extrahepatic bile duct cancer stage III

description: Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.)


Aplastic bone marrow

description: Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells.


name: Grade 2 Pleura Intra-Operative Injury, CTCAE


Cerebellar Paraganglioma

description: An extra-adrenal paraganglioma arising from the cerebellum.


name: Grade 4 Oral Intra-Operative Injury, CTCAE


name: Lymphoma by Lukes-Collins Classification (Antiquated)


name: High Grade Prostatic Intraepithelial Neoplasia

description: Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts.  The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio.  The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform.  The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.


name: Grade 5 Intraoperative Renal Injury, CTCAE

description: Death


Grade 5 Pyramidal Tract Syndrome, CTCAE

description: Death


Grade 2 Feminization Acquired, CTCAE

description: Moderate symptoms; medical intervention indicated


Stage IV Ureter Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


Grade 2 Urinary Incontinence, CTCAE

description: Spontaneous; pads indicated; limiting instrumental ADL


Grade 5 Duodenal Hemorrhage, CTCAE

description: Death


name: Grade 4 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Mixed Phenotype Acute Leukemia, B/T/Myeloid

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of B-cell, T-cell, and myeloid lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Grade 3 Ileal Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


name: Bladder Urothelial Carcinoma, High Grade

description: Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Grade 3 Hypoxia, CTCAE

description: Decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg)


Crude Oil Exposure

description: Environmental, occupational, or consumer-based exposure to volatiles derived from the organic compounds and polycyclic aromatic hydrocarbons and particulates that are present in crude oil.


name: Post transplant Epstein-Barr virus associated lymphoproliferative disorder

description: A lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


name: Stage I Lentigo Maligna Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Grade 3 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Lacrimal Drainage System Mucoepidermoid Carcinoma

description: A carcinoma that arises from the lacrimal sac. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Paratesticular tumor

description: A benign, borderline, or malignant neoplasm that affects the paratesticular structures.


name: Grade 4 Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 1 Pulmonary Hypertension, CTCAE

description: Minimal dyspnea; findings on physical exam or other evaluation


name: Pathologic Stage III Merkel Cell Carcinoma AJCC v8

description: Stage III includes: IIIA: (T1-4, N1a(sn) or N1a, M0); (T0, N1b, M0); IIIB: (T1-4, N1b-3, M0). T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1a(sn): Clinically occult regional lymph node metastasis identified only by sentinel lymph node biopsy. N1a: Clinically occult regional lymph node metastasis following lymph node dissection. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Hypothalamic Gangliocytoma

description: A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the hypothalamus. It is often associated with the presence of pituitary gland adenomas. Symptoms include acromegaly and precocious puberty.


Solicited Adverse Event

description: An adverse event that is reported by a healthcare professional, consumer, or patient through an organized data collection system.


name: Grade 5 Gastrointestinal Stoma Necrosis, CTCAE

description: Death


AIDS-Related Cervical Carcinoma

description: A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


name: CNS Necrosis and Cystic Progression, CTCAE


name: First-degree perineal laceration during delivery

description: Injury to perineal skin only. (reVITALize)


Emaciation

description: An extreme loss of muscle and subcutaneous fat that is caused by malnutrition, and which results in a severely thin (emaciated) appearance.


Grade 4 Vaginal Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


P1 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) APRPD is 10 to less than 15 mm, 2) central calyceal dilation may be present, but peripheral calyceal dilation is considered to increase risk, 3) renal parenchyma should have normal thickness and appearance, 4) the ureter is not seen, and 5) the bladder is normal. If there is central calyceal dilation but the APRPD is less than 10 mm, it is still considered UTD P1. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Anosmia, CTCAE

description: A disorder characterized by a change in the sense of smell.


name: Grade 4 Prostate Stricture or Stenosis, CTCAE


name: Acute Myeloid Leukemia with t(4;11)(q21.3;q23.3); AFF1-KMT2A

description: An acute myeloid leukemia associated with t(4;11)(q21.3;q23.3) resulting in AFF1-KMT2A gene fusion.


name: Upper Aerodigestive Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


name: Psoriatic arthritis with distal interphalangeal joint involvement

description: Psoriatic arthritis with a particular pattern of involvement that affects the joints closest to the nails in both fingers and toes.


name: Grade 1 Conjunctiva Intra-Operative Injury, CTCAE


name: Hereditary Transthyretin Amyloid Cardiomyopathy

description: Transthyretin amyloid cardiomyopathy caused by mutation(s) in the TTR gene, encoding transthyretin.


name: Grade 4 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Aerodigestive Invasive Malignancy

description: A finding indicating the presence of an invasive malignant neoplasm involving the respiratory tract and the upper digestive tract.


Grade 4 Bronchopulmonary Dysplasia, AE

description: An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen AND positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for greater than 30% oxygen AND positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


name: Grade 1 Gastroesophageal Reflux Disease, CTCAE

description: Mild symptoms; intervention not indicated


Acute Myeloid Leukemia with BCOR-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of BCOR-RARA fusion protein.


Childhood Endocrine Neoplasm

description: A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ during childhood.


Stage IA Pancreatic Cancer AJCC v8

description: Stage IA includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Urostomy Site Bleeding, CTCAE

description: A disorder characterized by bleeding from the urostomy site.


name: Grade 2 Cranial Nerve X Neuropathy, CTCAE


name: Grade 1 Eye Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated; no change in vision


Hepatic Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the liver.


name: Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Necrotizing Enterocolitis, AE

description: An adverse event in a newborn characterized by confirmed necrotizing enterocolitis; major care change indicated (e.g. NPO, antibiotics, non-urgent surgery).


name: Childhood Acute Lymphoblastic Leukemia CNS-Positive Toronto Guidelines v2

description: Clinical signs of CNS involvement or blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Substance Intoxication Delirium

description: A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance intoxication.


Lip Infection, CTCAE

description: A disorder characterized by an infectious process involving the lips.


Grade 5 Oral Hemorrhage, CTCAE

description: Death


name: Stage IIIA Uterine Corpus Cancer AJCC v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Grade 3 Cornea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pericarditis, CTCAE

description: A disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart).


Grade 4 Hypokalemia, CTCAE

description: <2.5 mmol/L; life-threatening consequences


Grade 4 Lipase Increased, CTCAE

description: >5.0 x ULN and with signs or symptoms


name: Grade 3 Fallopian Tube Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

description: A neoplasm of hematopoietic and lymphoid cell origin that affects the skin.


name: Grade 2 Intraoperative Reproductive Tract Injury, CTCAE

description: Partial resection of injured organ/structure indicated


name: Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during adulthood.


Early Stage Malignant Skin Neoplasm

description: A stage term that refers to a malignant tumor confined to a limited area of the skin without lymph node or distant metastases.


name: Acute Myeloid Leukemia with SRSF2 Mutation

description: An acute myeloid leukemia associated with SRSF2 gene mutation.


Stage IV Vulvar Cancer AJCC v8

description: Stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis (including pelvic lymph node metastasis). (from AJCC 8th Ed.)


Grade 4 Papulopustular Rash, CTCAE

description: Life-threatening consequences


name: Adverse Event Associated with Growth and Development


Shingles, CTCAE

description: A disorder characterized by the reactivation of herpes zoster virus.


name: Adverse Event Associated with the Nervous System


Locally Advanced Lymphoma

description: Lymphoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 4 Visceral Arterial Ischemia, CTCAE

description: Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


name: High Grade Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is high-grade.


Prostatic Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the prostate gland.


name: Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Conditioned Insomnia

description: Insomnia that results from a developed tendency to not sleep well under particular conditions.


Broad Ligament Serous Cystadenoma

description: A rare serous cystadenoma arising from the broad ligament.


Grade 3 Aortic Valve Disease, CTCAE

description: Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


Grade 3 Jejunal Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated


name: Refractory Non-Muscle Invasive Bladder Carcinoma

description: Non-muscle invasive bladder carcinoma that is resistant to treatment.