Childhood Dermal Nevus

description: A dermal nevus that occurs during childhood.


name: Adenocarcinoma in situ in villous adenoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A non-invasive adenocarcinoma arising from a villous adenoma.


Childhood Gemistocytic Astrocytoma

description: A gemistocytic astrocytoma that occurs during childhood.


Grade 1 Sensory Neuropathy, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Grade 1 Trachea Intra-Operative Injury, CTCAE


Vaginal Mesonephric Adenocarcinoma

description: Vaginal adenocarcinoma that derives from Wolffian duct remnants and shows mesonephric differentiation.


name: FIGO Stage IIB Gestational Trophoblastic Tumor


name: Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Adult Acquired Toxoplasmosis

description: Toxoplasmosis acquired in adulthood.


High Grade Sarcoma

description: A sarcoma with the morphologic features of a high-grade tumor and lack of cellular differentiation.


name: Grade 4 Esophagus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Conduction Disorder, CTCAE

description: A disorder characterized by pathological irregularities in the cardiac conduction system.


Grade 2 Pharyngeal Mucositis, CTCAE

description: Moderate pain, analgesics indicated; altered oral intake; limiting instrumental ADL


Grade 4 Extrapyramidal Disorder, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Uterus Stricture or Stenosis, CTCAE


name: Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Infusion Related Toxicity

description: Toxicity related to an infusion.


Locally Recurrent Malignant Neoplasm

description: The reemergence of a malignant neoplasm after a period of remission at the site of the original tumor or adjacent to it.


Pediatric Obesity

description: A condition in which a child's body mass index (BMI) falls at or above the 95th percentile based on the normative values for the age and sex of the reference population.


Grade 5 Abdominal Infection, CTCAE

description: Death


Cerebellar Glioblastoma

description: A glioblastoma that occurs in the cerebellum.


Grade 4 Sinus Disorder, CTCAE

description: Necrosis of soft tissue or bone; urgent operative intervention indicated


name: Acute Lymphoblastic Leukemia by ROSE Cluster

description: Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE).


Bilateral Proliferative Retinopathy

description: Proliferative retinopathy occurring in both eyes.


name: Grade 2 Duodenum Stricture or Stenosis, CTCAE


Stage IVB Bone Cancer AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


name: Grade 2 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Ureter Stricture or Stenosis, CTCAE


name: Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: Umbilical hernia without mention of obstruction or gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the umbilicus, without mention of obstruction or necrosis of the herniated contents.


name: Grade 2 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Locally Advanced Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Non-small cell carcinoma

description: A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma.


Tumors Derived from Langerhans Cells

description: This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017)


Racial Melanosis

description: A benign conjunctival finding noted especially among darker pigmented individuals. While it is typically found perilimbally and bilaterally, it can also cover the conjunctivae extensively and may present asymmetrically. The flat, non-cystic pigmentation may increase in size with age. It is rare to have this finding evolve into conjunctival melanoma.


Grade 5 Tracheal Obstruction, CTCAE

description: Death


Broad Ligament Wolffian Tumor

description: An epithelial neoplasm of Wolffian (mesonephric) origin arising from the broad ligament. Most tumors behave in a benign fashion.


Grade 1 Tendon Reflex Decreased, CTCAE

description: Ankle reflex reduced


name: Grade 3 Central Nervous System Hemorrhage, CTCAE


name: Grade 4 Genitourinary Stoma Obstruction, CTCAE


name: Pathologic Stage IIID Cutaneous Melanoma AJCC v8

description: Stage IIID includes: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Grade 3 Intraoperative Neurological Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


name: Grade 1 Duodenum Stricture or Stenosis, CTCAE


name: Recurrent Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA

description: The reemergence of acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA after a period of remission.


Chest Pain - Cardiac, CTCAE

description: A disorder characterized by substernal discomfort due to insufficient myocardial oxygenation e.g., angina pectoris.


name: Grade 3 Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Atelectasis, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Grade 2 Agitation, CTCAE

description: Moderate mood alteration


name: Stage M3 Childhood Ependymoma by Toronto Guidelines v2

description: Visible metastasis in spine or visible metastasis in cervicomedullary junction. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Midgut Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the jejunum, ileum, proximal colon, or appendix.


name: Grade 1 Muscular and Skeletal Hypoplasia, CTCAE


name: Grade 3 Retroperitoneum Hemorrhage, CTCAE


name: Idiopathic Dysplasia of Uncertain Significance

description: Prominent hematopoietic cell dysplasia with mild or absent cytopenia. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


name: Schizophrenia and other psychotic disorders

description: A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Tubal Hyperplasia

description: Benign proliferation of the fallopian tube epithelium.


Grade 3 Concentration Impairment, CTCAE

description: Severe impairment in attention or decreased level of concentration; limiting self care ADL


name: acute combined systolic and diastolic congestive heart failure

description: Acute congestive heart failure due to reduced contractility of the left ventricle and which does not fill properly due to decreased compliance.


Atrioventricular Block Complete, CTCAE

description: A disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles.


Abnormal Finding

description: A decision that an observation or result is outside the parameters considered normal.


Trichilemmal carcinoma

description: A rare malignant tumor arising from the outer hair sheath and infundibulum on the face. It is considered the malignant counterpart of tricholemmoma. Complete surgical excision is required.


name: Grade 3 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Stage IIIB Vulvar Cancer AJCC v7

description: Stage IIIB includes: (T1/T2, N2a/N2b, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Grade 3 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

description: Asymptomatic decrease of >8 units drop; >5 units drop along with the presence of pulmonary symptoms (e.g., >Grade 2 hypoxia or >Grade 2 dyspnea); intervention indicated


name: Low Grade Gastric Intraepithelial Neoplasia

description: A gastric intraepithelial lesion characterized by the presence of neoplastic cells with mild cytologic atypia, mild architectural changes, and low number of mitotic figures.


Laryngeal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the larynx.


name: Anaplastic Large Cell Lymphoma, Lymphomatoid Papulosis-Like Histology

description: An anaplastic large cell lymphoma characterized by the presence of histopathologic features reminiscent of lymphomatoid papulosis. These features include the presence of Hodgkin-like cells in a background of acute and chronic inflammation.


Grade 3 Ascites, CTCAE

description: Severe symptoms; invasive intervention indicated


Sinus Tachycardia, CTCAE 5.0

description: A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node.


name: Hodgkin's disease, lymphocytic depletion of lymph nodes of multiple sites

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Adenocarcinoma of the prostate stage III

description: Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Neonatal Intraventricular Hemorrhage, AE

description: An adverse event in a newborn characterized by bleeding into the lateral cerebral ventricles.


name: Grade 3 Peritoneal Cavity Intra-Operative Injury, CTCAE


Grade 1 Pleuritic Pain, CTCAE

description: Mild pain


Erosion lesion

description: An eating away or breakdown of any type of external or internal human tissue including but not limited to skin, teeth, mucosa, or somatic, which involves only the outer tissue layer. When tissue surrounds an implanted device, the tissue breakdown may result in migration and loss of the implant material and may result in further complications such as infection or abscess.


Grade 1 Myelitis, CTCAE

description: Asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign)


Unresectable Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and is not amenable to surgical resection.


name: Grade 3 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Biliary Tract Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 5 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Carcinoma Metastatic to the Skin

description: A carcinoma that has spread to the skin from its original site of gowth.


Testicular Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the testis.  Representative examples include infection, torsion, and infarction.


name: Grade 3 Injury To Inferior Vena Cava, CTCAE

description: Severe symptoms; limiting self care ADL; repair or revision indicated


name: Endocrine Disorders - Other, Specify, CTCAE


Mucosal Infection, CTCAE

description: A disorder characterized by an infectious process involving a mucosal surface.


Grade 3 Hematoma, CTCAE

description: Transfusion; invasive intervention indicated


name: Advanced Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Metastatic Melanoma

description: Metastatic melanoma that is resistant to treatment.


Stage IV Bone Sarcoma AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


name: Grade 5 Fallopian Tube Obstruction, CTCAE


Pancreatic Hepatoid Adenocarcinoma

description: A rare adenocarcinoma that arises from the pancreas.  It is characterized by marked hepatocellular differentiation.


Stage I Ampulla of Vater Cancer AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2, N0, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 1 Other Dermatology or Skin, CTCAE


name: Acute Myeloid Leukemia with idic(X)(q13)

description: Acute myeloid leukemia associated with isodicentric chromosome Xq13 [idic(X)(q13)].


name: Grade 3 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Kidney Pain, CTCAE

description: Kidney pain that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


name: Grade 4 Urethral Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Non-Muscle Invasive Bladder Urothelial Carcinoma

description: An infiltrating urothelial carcinoma of the bladder that has not invaded into the bladder muscularis propria.


name: Cranial Nerve VIII Intra-Operative Injury, CTCAE


name: Grade 1 Prolapse of Intestinal Stoma, CTCAE

description: Asymptomatic; reducible


name: Grade 5 Surgical and Medical Procedures - Other, Specify, CTCAE

description: Death


Grade 1 Gallbladder Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Non-Invasive Cribriform Carcinoma

description: A carcinoma characterized by the presence of a cribriform architectural pattern. There is no evidence of surrounding stromal invasion by the malignant cells.


name: Chronic Myelomonocytic Leukemia with Eosinophilia Associated with t(5;12)(q31;p12)

description: Chronic myelomonocytic leukemia characterized by the presence of eosinophilia, PDGFRB gene rearrangement, and t(5;12)(q31;p12).


Torsade de Pointes, CTCAE

description: A type of polymorphic ventricular tachycardia (VT) characterized by a gradual change in the amplitude and twisting of the QRS complexes around the isoelectric line.


Grade 1 Platelet Count Decreased, CTCAE

description: <LLN-75,000/mm3; <LLN-75.0 x 10e9/L


name: Stage IVB Oral Cavity Verrucous Carcinoma


Stage IVA Gallbladder Cancer AJCC v8

description: Stage IVA includes: T4, N0-1, M0. T4: Tumor invading the main portal vein or hepatic artery or invading two or more extrahepatic organs or structures. N0: No regional lymph node metastasis. N1: Metastases to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 2 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


name: Grade 3 Aspartate Aminotransferase Increased, CTCAE

description: >5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


name: Grade 4 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Urinary Tract Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Mitochondrial Uncoupling Protein 2 Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene UCP2, encoding mitochondrial uncoupling protein 2, which plays a role in attenuating insulin secretion.


Supratentorial Ependymoma

description: A circumscribed ependymoma that arises from the supratentorial region of the brain. The diagnosis of supratentorial ependymoma should be made either when genetic analysis did not reveal a fusion gene involving ZFTA or YAP1 genes (not elsewhere classified -NEC) or when the genetic analysis was unsuccessful or not reported (not otherwise specified-NOS).


Pediatric Disorder

description: A non-neoplastic or neoplastic disorder which occurs during infancy, childhood, or adolescence.


name: Grade 4 Atrioventricular Block Complete, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 3 Renal Colic, CTCAE

description: Hospitalization indicated; limiting self care ADL


Non-Neoplastic Anorectal Disorder

description: A non-neoplastic disorder that affects the anus and rectum.


Grade 5 Pleural Effusion, CTCAE

description: Death


Grade 4 Spinal Fracture, CTCAE

description: Life-threatening consequences; symptoms associated with neurovascular compromise


name: Grade 1 Major Visceral Artery Intra-Operative Injury, CTCAE


name: Grade 4 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Uterine Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the uterus and another organ or anatomic site.


name: Grade 1 Breast Volume and Hypoplasia, CTCAE


name: Grade 3 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Libido Increased, CTCAE

description: A disorder characterized by an increase in sexual desire.


name: Columnar Cell Change of the Breast with Atypia

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Cytologic atypia is present.


name: Grade 3 Cranial Nerve IV Intra-Operative Injury, CTCAE


name: Grade 1 Teeth Intra-Operative Injury, CTCAE


Grade 5 Hypophysitis, CTCAE

description: Death


Grade 2 Glaucoma, CTCAE

description: EIOP which can be reduced to 21 mmHg or under with topical medications and no visual field deficit


name: Grade 2 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Ear and Labyrinth Disorders - Other, Specify, CTCAE


Body Odor, CTCAE

description: A disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body.


Foregut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the esophagus, stomach, or duodenum.


Asymptomatic Inflammatory Prostatitis

description: Inflammation of the prostate gland that is not associated with any symptoms. It is characterized by the presence of inflammatory cells in the prostatic fluid.


Extramural Nodule

description: A small aggregate of cells found in adipose tissues, particularly those attached to the colon where the architectural details of the lymph node cannot be identified with certainty under the microscope.  It may represent a lymph node completely replaced by metastatic cancer.


name: Complete unbalanced atrioventricular canal defect

description: Atrioventricular septal defect in which there is usually a single dominant ventricle and a hypoplastic ventricle.


Refractory Cytomegalovirus Infection

description: A cytomegalovirus infection that is resistant to treatment.


Grade 5 Malabsorption, CTCAE

description: Death


Liver Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the liver. The Ki-67 index is higher than 20%.


name: Serum Glutamic Pyruvic Transaminase, CTCAE


name: AIDS-Related Diffuse Large Cell Lymphoma

description: A diffuse large cell lymphoma developing in an HIV positive patient.


name: Grade 2 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Fat Atrophy, CTCAE

description: Covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL


Grade 2 Oral Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Recurrent Low Grade Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial low-grade endometrioid adenocarcinoma after a period of remission.


name: Deletion of Chromosome 22 Associated Meningioma

description: A meningioma that is associated with deletion of chromosome 22.  This abnormality is the most consistent cytogenetic finding that is detected in meningiomas.


Mouth cyst

description: A cystic lesion located in the oral cavity.


Grade 5 Conduction Disorder, CTCAE

description: Death


Stage IB Merkel Cell Carcinoma AJCC v7

description: Stage IB includes: T1, cN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Erectile Dysfunction, CTCAE

description: A disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.


name: Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage IV Ampulla of Vater Cancer AJCC v7

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (from AJCC 7th Ed.)


FEV1, CTCAE

description: An adverse event marked by a change in FEV1 lung function.


name: Grade 1 Spermatic Cord Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Bone Schwannoma

description: A very rare schwannoma of the bone. It is often located in the mandible and is well circumscribed.


name: Grade 1 Lens Intra-Operative Injury, CTCAE


Esophageal dysplasia

description: A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000)


Melanocytic matricoma

description: A rare benign pilar tumor with numerous intratumoral pigmented dendritic melanocytes. It typically affects elderly men. The most common location is the head and neck, followed by the trunk and the limbs. It manifests as a small, pigmented, purple or brownish-black papule or nodule. (WHO 2018)


name: Grade 3 Proptosis and Enophthalmos, CTCAE


Stage II Vaginal Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Uterine Infection, CTCAE

description: A disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.


name: Precursor T-lymphoblastic lymphoma/leukemia stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Radiating Chest Pain Along Left Lower Sternal Border

description: The location of the radiating chest pain is along the left lower sternal border.


name: Grade 4 Intraoperative Cardiac Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Larynx Obstruction and Stenosis, CTCAE


Childhood Malignant Solid Neoplasm

description: A malignant solid neoplasm that occurs during childhood.


Suicide Attempt, CTCAE

description: A disorder characterized by self-inflicted harm in an attempt to end one's own life.


Grade 4 Renal Calculi, CTCAE

description: Life-threatening consequences; urgent invasive intervention indicated


Infant Acute Undifferentiated Leukemia

description: An acute undifferentiated leukemia that occurs in infancy.


name: Grade 1 Prolapse of Gastrointestinal Stoma, CTCAE


Grade 5 Tracheitis, CTCAE

description: Death


Acute gastritis

description: Acute inflammation of the stomach.


Periodontal Disease, CTCAE

description: A disorder in the gingival tissue around the teeth.


name: Stage IIIA Ampulla of Vater Cancer AJCC v8

description: Stage IIIA includes: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N1: Metastasis to one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 5 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Argentaffinoma

description: A carcinoid tumor that shows atypical characteristics and has borderline malignant potential.


Zonular dehiscence

description: Rupture of the fibrous strands connecting the ciliary body and the crystalline lens of the eye.


Closed dislocation

description: A dislocation not complicated by an external wound


Grade 1 Tremor, CTCAE

description: Mild symptoms


Sickle Beta 0 Thalassemia

description: A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease.


name: Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


Unresectable Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that is not amenable to surgical resection.


name: Grade 5 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Infant Acute Lymphoblastic Leukemia without KMT2A Rearrangement

description: An acute lymphoblastic leukemia without rearrangement of the KMT2A gene that occurs in infancy.


name: Grade 4 Pneumonitis and Pulmonary Infiltrates, CTCAE


name: Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Myelodysplastic Syndrome, Not Otherwise Specified without Dysplasia

description: A premalignant hematologic condition characterized by cytopenia and absence of bone marrow dysplasia. There are less than 5% blasts in bone marrow and less than 2% blasts in peripheral blood.


Malposition of uterus

description: Orientation of the uterus in an unusual anatomic location or position.


name: Grade 3 Bronchopulmonary Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 1 Ureter Stricture or Stenosis, CTCAE


name: Grade 2 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Facial Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the face.


Stage III Fallopian Tube Cancer AJCC v8

description: Stage III includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0; IIIB: T3b, N0/N1, M0; IIIC: T3c, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. T3b: Fallopian tube cancer with macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension with or without metastasis to the retroperitoneal lymph nodes. T3c: Fallopian tube cancer with macroscopic peritoneal metastasis beyond the pelvis more than 2 cm in greatest dimension with or without metastasis to the retroperitoneal lymph nodes (includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ). N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


name: Type II Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the coronary sinus.


name: Grade 5 Other Sexual Reproductive Function, CTCAE


Grade 5 Gallbladder Necrosis, CTCAE

description: Death


name: Hepatocyte Nuclear Factor 4-Alpha Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4-alpha. This condition may progress to diabetes later in life.


Grade 1 Paresthesia, CTCAE

description: Mild symptoms


Lateral developmental cyst of jaw

description: A developmental odontogenic cyst lined by non-keratinized epithelium, occurring on the lateral aspect or between the roots of erupted teeth. (WHO 2017)


name: Grade 4 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Cystine urolithiasis

description: Urolithiasis in which the composition of the stones is predominantly cystine.


name: Renal Pelvis and Ureter Cancer by AJCC v8 Stage

description: A term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to renal pelvis and ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. It does not apply to renal cell carcinomas (are staged according to the classification for kidney), renal medullary carcinomas (are staged according to the classification for kidney), collecting duct carcinomas (are staged according to the classification for kidney),  lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and mesenchymal tumors (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs). (from AJCC 8th Ed.)


Megacystis - Megaureter

description: A condition characterized by a large capacity, thin-walled bladder and megaureter(s).


name: Grade 1 Larynx Obstruction and Stenosis, CTCAE


name: Grade 3 Vaginal Stenosis and Length, CTCAE


Grade 3 Papulopustular Rash, CTCAE

description: Papules and/or pustules covering >30% BSA with moderate or severe symptoms; limiting self-care ADL; IV antibiotics indicated


Condyloma Acuminatum with Dysplasia

description: Condyloma acuminatum that is associated with the presence of dysplastic epithelial changes.


Adenoma, Trabecular

description: A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.


Recurrent Adult Brain Neoplasm

description: The reemergence of brain neoplasm in adulthood after a period of remission.


Low Grade Mucinous Carcinoma Peritonei

description: A low-grade mucinous adenocarcinoma that has spread to the peritoneum.


Grade 4 Hepatitis Viral, CTCAE

description: Life-threatening consequences; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)


Stage 0is Urethral Cancer AJCC v8

description: Stage 0is includes: Tis, N0, M0. Tis: For male penile urethra and female urethra: Carcinoma in situ. For prostatic urethra: Carcinoma in situ involving the prostatic urethra or periurethral or prostatic ducts without stromal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage I Ureter Cancer AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 3 Gingival Pain, CTCAE

description: Severe pain; inability to aliment orally


name: Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Retinopathy of Prematurity, AE

description: An adverse event in a newborn characterized by bilateral retinal detachment and blindness.


Adenocarcinoma in villous adenoma

description: A non-invasive or invasive adenocarcinoma arising from a villous adenoma.


name: Advanced Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IB Osteosarcoma AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: FIGO Stage IIIA Gestational Trophoblastic Tumor


name: Grade 4 Neonatal Respiratory Distress Syndrome, AE

description: A respiratory distress adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; requiring urgent care change (e.g. urgent intubation).


name: Paratesticular Clear Cell Adenocarcinoma

description: An exceedingly rare adenocarcinoma that arises from the paratesticular structures. It is characterized by the presence of columnar, hobnail, and polygonal cells with clear cytoplasm.


Grade 4 Hip Fracture, CTCAE

description: Life-threatening consequences; symptoms associated with neurovascular compromise


Grade 4 Hypothyroidism, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 2 Non-Cardiac Chest Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Grade 2 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acquired Cataract

description: Cataract that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Oropharyngeal Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the oropharynx.


Stage IIIC1 Cervical Cancer FIGO 2018

description: Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


name: Recurrent Small Cell Neuroendocrine Carcinoma

description: The reemergence of small cell neuroendocrine carcinoma after a period of remission.


name: Grade 1 Gamma-Glutamyl Transpeptidase, CTCAE


name: Invasive Plasmacytoid Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of malignant cells with plasmacytoid features.


Stage IIA Gastric Cancer AJCC v7

description: Stage IIA includes: (T3, N0, M0); (T2, N1, M0); (T1, N2, M0). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Grade 3 Injection Site Reaction or Extravasation Changes, CTCAE


Grade 2 Flashing Lights, CTCAE

description: Limiting instrumental ADL


Death Neonatal, CTCAE

description: Newborn death occurring during the first 28 days after birth.


Grade 1 Vaginal Dryness, CTCAE

description: Mild vaginal dryness not interfering with sexual function


name: Locally Advanced Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Ampulla of Vater Hepatoid Adenocarcinoma

description: A very rare adenocarcinoma that arises from the ampulla of Vater.  It is usually of the intestinal type and is characterized by the presence of malignant polygonal cells with abundant eosinophilic cytoplasm resembling hepatocytes.


Grade 3 Rectal Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Pharyngeal Mucositis, CTCAE

description: A disorder characterized by ulceration or inflammation involving the mucous membrane of the pharynx.


Stage IA Bone Sarcoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 3 Weight Loss, CTCAE

description: >=20% from baseline; tube feeding or TPN indicated


name: Locally Advanced Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Small Intestinal Perforation, CTCAE 5.0

description: A disorder characterized by a rupture in the small intestine wall.


Bladder Endometrioid Adenocarcinoma

description: A rare bladder adenocarcinoma with the histologic characteristics of endometrioid adenocarcinoma of the endometrium.


Lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Metastatic Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


name: Urethra Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Appendix Tubular Carcinoid

description: A neuroendocrine tumor that arises from the appendix.  It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules.


name: Grade 2 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Merkel Cell Carcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


name: Grade 3 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Small Intestinal Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 5 Uterine Anastomotic Leak, CTCAE

description: Death


name: Grade 5 Carbon Monoxide Diffusion Capacity, CTCAE


Smoldering Systemic Mastocytosis

description: Slowly progressive systemic mastocytosis with uncertain prognosis. It is characterized by organomegaly and absence of aggressive disease.


Fibrinogen Decreased

description: A laboratory test result which indicates decreased levels of fibrinogen in a biological specimen.


Larynx Edema, CTCAE

description: Laryngeal edema resulting from a known treatment.


Obesity, CTCAE

description: A disorder characterized by having a high amount of body fat.


Grade 4 Platelet Count Decreased, CTCAE

description: <25,000/mm3; <25.0 x 10e9/L


Fibrolipoma

description: A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue.


Stage IIA Testicular Cancer AJCC v8

description: Stage IIA includes: (Any pT/TX, N1, M0, S0); (Any pT/TX, N1, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Childhood Benign Skin Melanocytic Nevus

description: A circumscribed proliferation of melanocytes in the skin that occurs during childhood. It is characterized by the absence of atypical or malignant cytological features, and absence of invasive features or metastatic potential.


name: Adult Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for adult Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 2 Localized Edema, CTCAE

description: Moderate localized edema and intervention indicated; limiting instrumental ADL


Stage IVA Cervical Cancer AJCC v9

description: Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Grade 1 Peripheral Sensory Neuropathy, CTCAE

description: Asymptomatic


name: Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: An invasive prostate adenocarcinoma characterized by the presence of malignant cells that exhibit neuroendocrine differentiation.


Psychological Dependence

description: A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug.


name: Grade 3 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Pleura Intra-Operative Injury, CTCAE


Body Fluid Leakage

description: The loss of any normal body fluid into the surrounding tissue or body cavity.


Grade 1 Lethargy, CTCAE

description: Mild symptoms; reduced alertness and awareness


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol. It is based on findings at surgery for patients who have not received chemotherapy prior to surgery. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 1 Haptoglobin Decreased, CTCAE

description: <LLN


Congenital postural scoliosis

description: Abnormal sideways curvature of the spine that is present at birth.


Grade 4 Seizure, CTCAE

description: Life-threatening consequences; prolonged repetitive seizures


name: Grade 5 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Bronchopulmonary Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the bronchial wall and/or lung parenchyma.


Grade 3 Pain of Skin, CTCAE

description: Severe pain; limiting self care ADL


Eye Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the eye.


name: Grade 3 Other Growth and Development, CTCAE


Grade 1 Scrotal Infection, CTCAE

description: Localized, local intervention indicated


name: Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intestinal Stoma Prolapse

description: An intestinal stoma complication characterized by protrusion of the intestine above the abdominal surface.


Rhabdomyolysis Related to COVID-19

description: Rhabdomyolysis in a patient with probable or confirmed acute COVID-19.


Cellular Blue Nevus

description: A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes. In occasional cases an increased mitotic activity, focal necrosis, and nuclear pleomorphism may be seen. Such cases with atypical features may have an uncertain malignant potential.


Elevated CA19-9

description: A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CA19-9 in a biological sample.


name: Grade 3 Neonatal Culture Positive Sepsis, AE

description: An adverse event in a newborn characterized by a positive blood culture positive with severe signs; supportive treatment escalated or initiated.


name: Grade 3 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Carcinoma in the Peritoneum

description: A carcinoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Laryngitis, CTCAE

description: A disorder characterized by an inflammatory process involving the larynx.


name: Grade 3 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Clinical Stage IV Retinoblastoma AJCC v8

description: Stage IV includes: Any cT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Refractory Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that is resistant to treatment.


name: Stage I Renal Pelvis and Ureter Cancer AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor invades subepithelial connective tissue. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Endometrial Transitional Cell Carcinoma

description: The reemergence of endometrial transitional cell carcinoma after a period of remission.


Refractory Low Grade Glioma

description: Low grade glioma that is resistant to treatment.


Oxyntic Gland Adenoma

description: A benign epithelial neoplasm composed of columnar cells with differentiation to chief cells, parietal cells, or both, with a high rate of progression to adenocarcinoma (submucosal invasion). (WHO 2019)


name: Adult Non-T Non-B Acute Lymphoblastic Leukemia

description: Non-T non-B acute lymphoblastic leukemia that occurs during adulthood.


name: Stage IIB Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIB includes: T3, N0, M0.  T3: Stomach: tumor penetrates subserosa; jejunum/ileum: tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa or invades into non-peritonealized tissues; ampulla/duodenum: tumor invades pancreas or retroperitoneum or into non-peritonealized tissues; colon or rectum: tumor invades through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Non-Obstructed Non-Refluxing Megaureter

description: A megaureter in which there is no obstruction at the ureterovesical junction and no vesicoureteral reflux.


name: Hodgkin's disease nodular sclerosis stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Resectable Melanoma

description: Melanoma that is amenable to surgical resection.


Grade 2 Joint Infection, CTCAE

description: Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral); needle aspiration indicated (single or multiple)


name: Grade 2 White Blood Cell Decreased, CTCAE

description: <3000-2000/mm3; <3.0-2.0 x 10e9/L


name: Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


name: Stage III Gastric Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Suicidal Ideation, CTCAE

description: Specific plan to commit suicide without serious intent to die which may not require hospitalization


name: Lugano Classification Stage I Childhood Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Creatinine Increased, CTCAE

description: >1.5-3.0 x baseline; >1.5-3.0 x ULN


name: Myeloproliferative Neoplasm, BCR-ABL1 Negative

description: A myeloproliferative neoplasm characterized by the absence of Philadelphia chromosome and BCR-ABL1 fusion gene expression. This group includes polycythemia vera, essential thrombocythemia, and primary myelofibrosis.


Stage IB2 Cervical Cancer

description: Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: High Grade Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal glandular epithelium.


Grade 1 Urticaria, CTCAE

description: Urticarial lesions covering <10% BSA; topical intervention indicated


name: Grade 4 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Neonatal Culture Negative Sepsis, AE

description: An adverse event in a newborn characterized by suspected sepsis with severe signs (e.g. fever, grunting); supportive treatment escalated or initiated.


name: Grade 4 Lower Gastrointestinal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Mediastinum Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 1 Ear Pain, CTCAE

description: Mild pain


Passive-Aggressive Personality Disorder

description: A disorder characterized by a pattern of indirect expression of hostility, including negativistic attitudes and passive resistance to demands for adequate performance in social and occupational situations.


Grade 5 Hepatitis B Reactivation, CTCAE

description: Death


name: Grade 4 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pneumonitis, CTCAE

description: Severe symptoms; limiting self care ADL; oxygen indicated


Grade 1 Cecal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 1 Investigations - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Adverse Event Attributed to Commercial Product

description: An indication that an adverse event is causally related to the use of a commercially available product.


Refractory Sarcoma

description: A sarcoma that does not respond to treatment.


Esophageal mucositis

description: An inflammatory process affecting the mucous membrane of the esophagus.


name: Non-Hodgkin Lymphoma with Variable Clinical Course

description: A non-Hodgkin lymphoma with variable clinical course.


Transferase Deficiency Galactosemia

description: A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase.


Hip Fracture, CTCAE

description: A finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken.


Radiating Chest Pain in Back

description: The location of the radiating chest pain is in the back.


name: Refractory Langerhans Cell Histiocytosis

description: Langerhans cell histiocytosis that does not respond to treatment.


name: Refractory Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that is resistant to treatment.


name: Mast Cell Leukemia with an Associated Myeloid Neoplasm

description: Mast cell leukemia associated with another clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia).


name: Grade 1 Bladder Stricture or Stenosis, CTCAE


Extrahepatic bile duct cancer stage I

description: Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0).  T1: Tumor confined to the bile duct histologically.  T2: Tumor invades beyond the wall of the bile duct.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IIB Prostate Cancer AJCC v8

description: Stage IIB includes: T1-2, N0, M0, PSA less than 20, Grade Group 2. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. (AJCC 8th ed.)


Ocular Graft Versus Host Disease

description: Graft versus host disease occurring in the eye.


Liver Neuroendocrine Neoplasm

description: An extremely rare neoplasm with neuroendocrine differentiation that arises from the liver. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Stage IB Uterine Corpus Cancer AJCC v7

description: Stage IB includes: T1b, N0, M0.  T1b: Tumor invades one-half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Acute Bilineal Leukemia

description: Acute bilineal leukemia that is resistant to treatment.


name: Grade 3 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Endometrial Carcinoma

description: Endometrial carcinoma that is resistant to treatment


Brain Damage, Chronic

description: Encephalopathy that is persistent or long-standing in nature.


name: Grade 5 Cranial Nerve X Neuropathy, CTCAE


Grade 2 Azoospermia, CTCAE

description: Absence of sperm in ejaculate


Grade 2 Dental Caries, CTCAE

description: Dental caries involving the root


name: Grade 1 Salivary Gland Intra-Operative Injury, CTCAE


Disorder by Site

description: A term that refers to the classification of a disorder according to the anatomic site that is involved in the pathologic process.


name: Grade 1 Prostate Intra-Operative Injury, CTCAE


Grade 3 Urinary Retention, CTCAE

description: Elective invasive intervention indicated; substantial loss of affected kidney function or mass


Jejunal fistula

description: An abnormal communication between the jejunum and another organ or cavity.


name: Locally Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 1 Stoma Pulmonary Hemorrhage, CTCAE


name: Malignant Lymphoma Follicular, Large Noncleaved Cell Type


Symmetric Chest Appearance

description: Inspection of the region of the anterior surface of the chest and epigastrium reveals an approximate correspondence of form and constituent configuration on opposite sides of a vertical central dividing line.


Esophageal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Postnasal Drip, CTCAE

description: A disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing.


Childhood Fibrillary Astrocytoma

description: A fibrillary astrocytoma that occurs during childhood.


name: Grade 1 Vagina Intra-Operative Injury, CTCAE


Grade 1 Fecal Incontinence, CTCAE

description: Occasional use of pads required


name: Grade 5 Stomach Stricture or Stenosis, CTCAE


name: Cervical Florid Reactive Lymphoid Hyperplasia

description: A dense, superficial benign lymphoid cell proliferation in the cervix. It almost always occurs in premenopausal women. It is composed of a mixture of large and small lymphocytes including immunoblasts. Plasma cells and neutrophils are also present. Immunohistochemical studies reveal a mixture of B and T lymphocytes, and polytypic plasma cells.


Lentiginous Melanocytic Nevus

description: A nevus characterized by an intraepidermal proliferation of nested melanocytes along the basal epidermis.


Metastatic malignant neoplasm to ureter

description: A malignant neoplasm that has spread to the ureter from another anatomic site.


name: Lugano Classification Stage IE Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Resectable Dedifferentiated Liposarcoma

description: Dedifferentiated liposarcoma that is amenable to surgical resection.


name: Grade 3 Gastrointestinal Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Dysphagia, CTCAE

description: Symptomatic, able to eat regular diet


name: Grade 1 Small Intestinal Mucositis, CTCAE

description: Asymptomatic or mild symptoms; intervention not indicated


name: Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that is resistant to treatment.


Grade 2 Neonatal Epileptic Seizure, AE

description: An adverse event in a newborn characterized by electroencephalogram (EEG)-proven seizures that are controlled with one anti-seizure drug (no recurrence within three days after treatment).


name: Venous Thrombosis Related to Vascular Access Complication

description: The formation of a thrombus in the vein as a direct result of an activity associated with vascular access.


Adult Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that occurs during adulthood.


Radial scar

description: A benign breast lesion characterized by the presence of fibrosis with stellate appearance in the parenchyma.  The lesions are often multiple and bilateral.  Grossly, the lesions are irregular and firm and resemble carcinoma.  Microscopically, the stellate lesions are composed of dense, hyalinized collagen.  Entrapped in the collagen are tubules.  There is no evidence of cytologic atypia.


Non-Encapsulated Neoplasm

description: A neoplasm that is non-capsulated.


Tracheal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the trachea.


Cranial Nerve Injuries

description: Injury to, or disease of, the cranial nerve


Grade 3 Insomnia, CTCAE

description: Severe difficulty in falling asleep, staying asleep or waking up early


name: Grade 4 Spermatic Cord Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 1 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


name: Grade 1 Blood Bilirubin Increased, CTCAE

description: >ULN-1.5 x ULN if baseline was normal; > 1.0-1.5 x baseline if baseline was abnormal


name: Human Papillomavirus-Related Vaginal Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is caused by human papillomavirus infection.


Adnexal mass

description: An abnormal growth in the ovary, fallopian tube, or surrounding connective tissue.


name: Grade 3 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Periodontal Disease, CTCAE

description: Spontaneous bleeding; severe bone loss with or without tooth loss; osteonecrosis of maxilla or mandible


name: Grade 4 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Grade 2 Urticaria, CTCAE

description: Urticarial lesions covering 10-30% BSA; oral intervention indicated


Non-ischemic Stroke

description: Any stroke that is not related to an obstructed blood vessel.


name: Recurrent Malignant Supratentorial Neoplasm

description: The reemergence of a malignant supratentorial neoplasm after a period of remission.


name: Grade 4 Ileum Stricture or Stenosis, CTCAE


Miniature Adult Form of AHC

description: An autosomal recessive or sporadic form of adrenal hypoplasia congenita frequently associated with central nervous system anomalies including anencephaly and pituitary defects. Histologically the adrenal gland is distinguished by the absence of fetal adrenal cortex and the presence of a small amount of normal, permanent adult adrenal cortex.


Congenital Coronary Artery Abnormality

description: A congenital condition referring to defects of the course and structure of the coronary arteries.


Arterial Injury, CTCAE

description: A finding of damage to an artery.


Dyspepsia, CTCAE

description: A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting.


name: Grade 4 Rectum Stricture or Stenosis, CTCAE


Adult Benign Cerebellar Neoplasm

description: A benign neoplasm of the cerebellum occurring in adults.


Esophagitis, CTCAE

description: A disorder characterized by inflammation of the esophageal wall.


name: Arachnoiditis and Meningismus and Radiculitis, CTCAE


Episodic Ataxia Type 2

description: An autosomal dominant condition caused by mutation(s) in the CACNA1A gene, encoding voltage-dependent P/Q-type calcium channel subunit alpha-1A. It is characterized by paroxysms of vertigo, visual disturbance, dysarthria, and ataxia.


name: Endometrial Endometrioid Adenocarcinoma with Small Nonvillous Papillae


Stage IB Bone Cancer AJCC v8

description: Stage IB includes: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Grade 2 Urinary Urgency, CTCAE

description: Limiting instrumental ADL; medical management indicated


name: Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage III Cervical Cancer AJCC v9

description: Stage III includes: T3, N0, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Uterine Perforation, CTCAE

description: A disorder characterized by a rupture in the uterine wall.


name: Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Uterus Stricture or Stenosis, CTCAE


name: Grade 1 Spermatic Cord Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: High Grade Conjunctival Melanocytic Intraepithelial Lesion

description: Conjunctival melanocytic intraepithelial lesion characterized by the presence of moderate to severe atypia.


Hormone Receptor Status

description: An indication of the presence or absence of detection of hormone receptor expression in a sample.


Agenesis

description: A congenital abnormality resulting in the absence of an anatomical structure.


Grade 5 Iron Overload, CTCAE

description: Death


name: Grade 3 Hypoxic Ischemic Encephalopathy, AE

description: An adverse event in a newborn characterized by moderate clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event; meeting criteria for therapeutic hypothermia.


Stage I Cervical Cancer FIGO 2018

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2018)


name: Grade 2 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Salivary Duct Inflammation, CTCAE

description: Slightly thickened saliva; slightly altered taste (e.g., metallic)


name: Grade II Glandular Intraepithelial Neoplasia


name: Grade 3 Associated with the Teeth, CTCAE


name: Recurrent Juvenile Myelomonocytic Leukemia

description: The reemergence of juvenile myelomonocytic leukemia after a period of remission.


description: An epithelioid hemangioendothelioma that occurs during childhood.


Grade 1 Dysuria, CTCAE

description: Present


Locally Advanced Osteosarcoma

description: Osteosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Neonatal Rash, AE

description: An adverse event in a newborn characterized by diffuse rash and vesicles or limited number of bullae or superficial ulcerations of mucous membranes limited to one site.


name: Grade 4 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Extrahepatic Bile Duct Cancer

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th ed.)


Grade 2 Erectile Dysfunction, CTCAE

description: Decrease in erectile function (frequency/rigidity of erections), erectile intervention indicated, (e.g., medication or mechanical devices such as penile pump)


Methotrexate-Associated Lymphoma

description: A non-Hodgkin or Hodgkin lymphoma that develops in patients who are immunosuppressed with methotrexate.


Transitory tachypnea of newborn

description: A respiratory disorder characterized by higher than normal respiratory rates among premature and cesarean section delivered neonates whose lungs have not fully matured. The cause is often excess fluid in the lungs, and resolution is aided by supplemental oxygen and sometimes, antibiotics.


Grade 4 Neonatal Rash, AE

description: An adverse event in a newborn characterized by extensive or generalized bullous lesions or ulceration of mucous membranes involving two or more distinct mucosal sites or Stevens-Johnson syndrome or toxic epidermal necrosis.


name: T Acute Lymphoblastic Leukemia with TAL1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of TAL1 gene rearrangement.


name: Grade 1 Nasal Cavity Intra-Operative Injury, CTCAE


name: Systemic lupus erythematosus, childhood onset

description: Systemic lupus erythematosus (SLE) diagnosed in individuals under the age of eighteen. Children frequently have multi-organ involvement and acute disease onset. Symptoms include fever, arthritis, skin lesions, anemia, and fatigue.


name: Grade 5 Other Constitutional Symptoms, CTCAE


Benign neoplasm of female breast

description: A neoplasm that arises from the breast in females and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 3 Neuralgia, CTCAE

description: Severe pain; limiting self care ADL


name: Eye Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


name: Grade 5 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Intraoperative Musculoskeletal Injury, CTCAE

description: Partial resection of injured organ/structure indicated


Grade 4 Menorrhagia, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Early T-precursor lymphoblastic leukemia/lymphoma

description: T lymphoblastic leukemia/lymphoma in which the blasts have unique immunophenotypic and genetic characteristics suggesting only limited early T-cell differentiation.


Posterior Fossa Neoplasm

description: A neoplasm that arises from the posterior cranial fossa. Examples include meningiomas and medulloblastomas.


Grade 4 Necrotizing Enterocolitis, AE

description: A necrotizing enterocolitis adverse event in a newborn characterized by bowel perforation (pneumoperitoneum)(modified Bell stage IIIB); shock, disseminated intravascular coagulation (DIC), combined respiratory and metabolic acidosis (modified Bell stage IIIA); urgent major care change indicated.


Urine Discoloration, CTCAE

description: A disorder characterized by a change in the color of the urine.


name: Grade 1 Tendon Intra-Operative Injury, CTCAE


Recurrent Atypical Meningioma

description: The reemergence of atypical meningioma after a period of remission.


name: Grade 1 Oral Cavity NOS Intra-Operative Injury, CTCAE


Grade 1 Anal Pain, CTCAE

description: Mild pain


name: Transient Myocardial Dysfunction of Newborn

description: A condition in a newborn characterized by a temporary decrease in right ventricular and/or left ventricular output.


Hutch diverticulum

description: A congenital out pouching of the bladder involving the ureteral hiatus.


name: Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Pulmonary Hypertension, CTCAE

description: Life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation)


name: Grade 3 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Radiculitis, CTCAE

description: Moderate symptoms; medical intervention indicated; limiting instrumental ADL


name: Spermatic Cord Stricture or Stenosis, CTCAE


Obesity-Associated Insulin Resistance

description: Insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.


Childhood Non-Ossifying Fibroma

description: A non-ossifying fibroma that occurs during childhood.


name: Clinical Stage IIC Cutaneous Melanoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Lymphoma, EBV-associated

description: Lymphoma that is caused by Epstein-Barr virus infection.


name: Grade 2 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Stage I Anal Canal Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


name: T Acute Lymphoblastic Leukemia with LMO2 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of LMO2 gene rearrangement.


name: Increased Time To Peak Drug Blood Concentration

description: Increased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


Cutaneous Malignant Melanoma 2

description: An autosomal dominant genetic disorder caused by mutations in the CDKN2A gene, encoding cyclin-dependent kinase inhibitor 2A. The condition is characterized by cutaneous malignant melanoma associated with this genetic alteration.


Stage IVA Appendix Carcinoma AJCC v8

description: Stage IVA includes: (Any T, N0, M1a); (Any T, Any N, M1b, G1). N0: No regional lymph node metastasis. M1a: Intraperitoneal acellular mucin, without identifiable tumor cells in the disseminated peritoneal mucinous deposits. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G1: Well differentiated. (AJCC 8th ed.)


name: Grade 4 Vas Deferens Stricture or Stenosis, CTCAE


Lipase Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen.


Chest Pain in Lower Sternum

description: The location of the chest pain is in the lower portion of the sternum.


name: Follicle Stimulating Hormone Receptor Deficiency

description: Reduced or absent function of the receptor for follicle stimulating hormone associated with a mutation in the FSHR gene.


name: Grade 3 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


name: Grade 4 Lens Intra-Operative Injury, CTCAE


name: Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Pharynx Intra-Operative Injury, CTCAE


Vaginal Obstruction, CTCAE 5.0

description: A disorder characterized by blockage of vaginal canal.


Adult L2 Acute Lymphoblastic Leukemia

description: L2 acute lymphoblastic leukemia that occurs during adulthood.


name: Central Nervous System SMARCB1/INI1-Deficient Tumor

description: A group of SMARCB1/INI1 deficient tumors that arise from the central nervous system. It includes highly aggressive and slow-growing tumors.


name: Grade 4 Upper Aerodigestive Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Intraoperative Respiratory Injury, CTCAE

description: Primary repair of injured organ/structure indicated


name: Grade 2 Breast Nipple and Areolar Deformity, CTCAE


name: Grade 4 Thrombotic Thrombocytopenic Purpura, CTCAE

description: Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)


name: Grade 5 Thrombosis or Thrombus or Embolism, CTCAE


name: Grade 5 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Clinical Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 3 Muscle Intra-Operative Injury, CTCAE


name: Grade 4 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Malignant Lymphoma by Cell Type (Working Formulation)


name: Old Burn Scar-Related Cutaneous Melanoma

description: A cutaneous melanoma that arises in an old burn scar tissue.


name: Stage I Intermediate Grade Adult Non-Hodgkin's Lymphoma


Vertigo, CTCAE

description: A disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo).


name: Grade 3 Gamma-Glutamyl Transpeptidase, CTCAE


Grade 5 Peritoneal Infection, CTCAE

description: Death


name: Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Reactive Vascular Proliferation

description: A non-neoplastic proliferation of vessels in reaction to a process.


name: Hepatic Vein Intra-Operative Injury, CTCAE


name: Recurrent Platinum-Resistant Fallopian Tube Carcinoma

description: The reemergence of platinum-resistant fallopian tube carcinoma after a period of remission.


Grade 3 Hiccups, CTCAE

description: Severe symptoms; interfering with sleep; limiting self care ADL


Stage IV Vulvar Cancer AJCC v6

description: Stage IV includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0); IVB (Any T, Any N, M1).  T4: Tumor invades any of the following: upper urethra bladder mucosa, rectal mucosa, or is fixed to the pubic bone.  N2: Bilateral regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th ed.)


Bladder Flat Urothelial Carcinoma

description: An in situ or invasive urothelial carcinoma that arises from the bladder wall and does not grow toward the hollow part of the bladder.


Grade 2 Tracheal Obstruction, CTCAE

description: Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


name: Grade 2 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intracranial Myeloid Sarcoma

description: A myeloid sarcoma that affects the meninges or the cerebral hemispheres.


Grade 2 Feeding Intolerance, AE

description: An adverse event in a newborn characterized by moderate feeding intolerance; resulting in minor discomfort or alteration of drinking behavior; minor care changes indicated (e.g. feeds withheld).


name: Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Esophagus Stricture or Stenosis, CTCAE


name: Grade 4 Other Hemorrhage and Bleeding, CTCAE


name: High Grade Cervical Intraepithelial Neoplasia

description: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


Grade 2 Akathisia, CTCAE

description: Moderate restlessness or increased motor activity; limiting instrumental ADL


name: Grade 2 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage IIIA Vulvar Cancer AJCC v8

description: Stage IIIA includes: T1-T2, N1, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 3 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Fibrosarcoma non-metastatic

description: Fibrosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


Anorectal infection

description: An infectious process affecting the anal area and the rectum.


Grade 5 Cholecystitis, CTCAE

description: Death


name: Grade 4 Uterus Intra-Operative Injury, CTCAE


Thrombocytopenic Disorder

description: A disorder of platelets characterized by a finding of low platelet concentrations (thrombocytopenia) typically below 50,000 platelets per microliter of blood.


name: Unspecified idiopathic peripheral neuropathy

description: Neuropathy, the cause of which is not known.


Spotty/Minimal Hemorrhage

description: Small (<3mm) foci of hemorrhage within the tumor.


Grade 4 Confusion, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Eosinophilia, CTCAE

description: A disorder characterized by laboratory test results that indicate an increased number of eosinophils in the blood.


name: Oligometastatic Malignant Solid Neoplasm

description: A malignant solid neoplasm that has metastasized to a limited number of sites— existing in a state intermediate between localized disease and widespread metastatic disease.


name: Persistent Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that never involves more than four separate joints after six months.


Locally Advanced Prostate Carcinoma

description: A prostatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Cervical Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the cervix. This category includes neuroendocrine tumor grade 1, neuroendocrine tumor grade 2, and neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma).


name: Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Grade 2 Ascites, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 1 Breast Intra-Operative Injury, CTCAE


name: Grade 4 Upper Extremity Artery Intra-Operative Injury, CTCAE


Childhood Neuroendocrine Tumor

description: A neuroendocrine tumor that occurs during childhood.


Flat-Topped Papular Lesion

description: A papular lesion with a flat surface.


name: Locally Advanced Non-Muscle Invasive Bladder Carcinoma

description: Non-muscle invasive bladder carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Pleural Effusion, CTCAE

description: A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.


Stage IA Uterine Corpus Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus carcinoma or carcinosarcoma with tumor limited to the endometrium or invading less than half the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Rectal Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of the intestinal contents in the rectum.


name: Grade 3 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 5 Myasthenia Gravis, CTCAE

description: Death


Pediatric Viral Infection

description: A viral infection that occurs during infancy, childhood or adolescence.


name: Grade 4 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Vas Deferens Stricture or Stenosis, CTCAE


name: Immune Checkpoint Inhibitor-related Myocarditis

description: Myocarditis associated with the therapeutic use of an immune checkpoint inhibitor.


name: Meningeal Melanocytoma of Intermediate Grade

description: A circumscribed meningeal melanocytic neoplasm with bland histological features and increased mitotic activity or invasion of the central nervous system.


Pressing Pain

description: A sensation of discomfort or distress from excess weight or pressure on a specific anatomical location.


name: Fetus Small for Gestational Age with Abdominal Circumference Less than Tenth Percentile

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and whose abdominal circumference falls below the tenth percentile.


Grade 2 Otitis Media, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Dusky Mucosa

description: A finding indicating the presence of dark discoloration on the mucosal surface. It is associated with tissue necrosis.


name: Refractory Abdominal Neuroendocrine Neoplasm

description: An abdominal neuroendocrine neoplasm that does not respond to treatment.


Grade 4 Arteritis Infective, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Nasal Cavity Intra-Operative Injury, CTCAE


Grade 3 Uterine Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 3 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Vaginal Large Cell Neuroendocrine Carcinoma

description: A rare, aggressive neuroendocrine carcinoma that arises from the vagina and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli.


Childhood Diffuse Large Cell Lymphoma

description: A diffuse large cell lymphoma occurring in children.


name: Recurrent EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: The reemergence of EBV-associated lymphoproliferative disease with primary immunodeficiency after a period of remission.


name: Retinoblastoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


name: Grade 4 Testes Stricture or Stenosis, CTCAE


name: Grade 5 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Diffuse Midline Glioma with EZHIP Overexpression

description: A diffuse midline glioma, H3 K27-altered, characterized by the presence of EZHIP overexpression.


Latent Infection

description: A period in which the infection is present in the host without producing overt symptoms.  (from Online Medical Dictionary)


name: Grade 3 Cardiac Ischemia or Infarction, CTCAE


name: Grade 4 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Testicular Sclerosing Sertoli Cell Tumor

description: A rare testicular Sertoli cell tumor characterized by the presence of neoplastic tubules that are surrounded by a dense fibrotic stroma.


name: Grade 2 Investigations - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Neonatal Sinus Tachycardia, AE

description: An adverse event in a newborn characterized by persistent sinus tachycardia; no change in age appropriate behavior; requiring minor care changes (e.g. concomitant medication changed).


Grade 2 Pneumonitis, CTCAE

description: Symptomatic; medical intervention indicated; limiting instrumental ADL


Grade 1 Epistaxis, CTCAE

description: Mild symptoms; intervention not indicated


Grade 3 Thromboembolic Event, CTCAE

description: Urgent medical intervention indicated (e.g., pulmonary embolism or intracardiac thrombus)


name: Foreign Body Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Elevated Serum CA-125 Tumor Antigen

description: A finding indicating elevated concentrations of the tumor antigen CA-125 in a blood serum sample.


name: Grade 1 Social Circumstances - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Stage IVA Uterine Corpus Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


Hormone Therapy Refractory Neoplasm

description: A neoplasm that does not respond to hormone therapy.


Arbovirus hemorrhagic fever

description: A group of viral illnesses that are vectored by arthropods, and that are characterized by increased susceptibility to bleeding diatheses.


name: Grade 3 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ovulatory Pain

description: Painful sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.


Grade 3 Ankle Fracture, CTCAE

description: Limiting self care ADL; elective operative intervention indicated requiring hospitalization


Grade 2 Generalized Edema, CTCAE

description: Interfering with instrumental ADLs; oral therapy initiated


Grade 5 Uterine Infection, CTCAE

description: Death


Urinary Tract Infection, CTCAE

description: A disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra.


name: Grade 4 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Cutaneous Melanoma

description: Cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Dysphagia, CTCAE

description: Death


Malignant Intracranial Neoplasm

description: A malignant neoplasm involving the intracranial space.


name: Cutaneous Acute Graft versus Host Disease

description: Skin manifestations of acute graft versus host disease, which typically presents as an erythematous maculopapular rash involving the face, ears, palms, and soles that may spread to the trunk and evolve to erythroderma.


name: Chronic Active EBV Infection of T-and NK-Cell Type, Systemic Form

description: An EBV-positive T-cell/NK-cell lymphoproliferative disorder characterized by repeated infectious mononucleosis-like symptoms, a very high titer of anti-EBV antibodies, and high levels of Epstein-Barr virus nucleic acids. Patients often develop progressive cellular and humoral immunodeficiency with pancytopenia and hypogammaglobulinemia.


name: Deep Venous Thrombosis Related to COVID-19

description: Deep vein thrombosis in a patient with probable or confirmed acute COVID-19.


name: Clinical Stage IA Cutaneous Melanoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Urinary Tract NOS Intra-Operative Injury, CTCAE


Breast Neurofibroma

description: A neurofibroma that arises from the breast.


Grade 2 Vasculitis, CTCAE

description: Moderate symptoms, medical intervention indicated


Gastric Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the stomach and another organ or anatomic site.


Diarrhea, CTCAE

description: A disorder characterized by an increase in frequency and/or loose or watery bowel movements.


name: Advanced Cutaneous Melanoma of the Extremity

description: Cutaneous melanoma of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 3 Superior Vena Cava Intra-Operative Injury, CTCAE


Grade 4 Hydrocephalus, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Radiation-induced fibrous mediastinitis

description: Fibrous mediastinitis arising due to radiation therapy.


name: Grade 1 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


name: Grade 3 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Delirium, CTCAE

description: Moderate and acute confusional state; limiting instrumental ADL


name: Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary small cell neuroendocrine carcinoma after a period of remission.


Sessile Serrated Adenoma/Polyp

description: Polyps that arises from the large intestine and the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


Intrapartum Uterine Rupture

description: An acute symptomatic tearing of the uterine wall after the onset of labor.


name: Childhood Acute Myeloid Leukemia with Minimal Differentiation

description: An acute myeloid leukemia with minimal differentiation occurring in children.


Perforation of organ

description: A rupture in an organ(s) due to traumatic or pathologic processes.


name: Stage III Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


name: Childhood Central Nervous System Neoplasm

description: A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in children.  Representative examples include posterior fossa astrocytoma, optic pathway glioma, medulloblastoma, ependymoma, and craniopharyngioma.


Grade 3 Psychosis, CTCAE

description: Severe psychotic symptoms (e.g., paranoid, extreme disorganization); hospitalization not indicated; new onset


name: Grade 3 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Recurrent Adnexal Carcinoma

description: The reemergence of adnexal carcinoma after a period of remission.


Metastatic Adnexal Carcinoma

description: Adnexal carcinoma that has spread from the original site of growth to other anatomic sites.


Regimen-Limiting Toxicity

description: A side effect of a drug or other treatment that is serious enough to necessitate a dose modification.


name: Grade 4 Cranial Nerve XII Neuropathy, CTCAE


name: Grade 1 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 3 Malaise, CTCAE

description: Uneasiness or lack of well being limiting self-care ADL


Musculoskeletal toxicity

description: A toxicity that impairs or damages the musculoskeletal system.


Grade 3 Irritability, CTCAE

description: Severe abnormal or excessive response; limiting self care ADL; inconsolable; medical or psychiatric intervention indicated


name: Grade 3 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Injury of diaphragm with open wound into cavity

description: Trauma to  the diaphragm associated with a break in the tissue that extends into the thoracic cavity.


Stage IIB Osteosarcoma AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)