name: Penile Human Papillomavirus-Independent Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the penis and is not caused by human papillomavirus infection. Morphologic variants include pseudohyperplastic, pseudoglandular, verrucous, papillary, and sarcomatoid carcinoma.


Penile intraepithelial neoplasia

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A precancerous neoplastic lesion that arises from the penis. It is characterized by dysplastic changes of the squamous epithelium with an intact basement membrane.


Bowenoid papulosis of penis

description: A cutaneous, usually multifocal lesion in the penis characterized by the presence of verrucous papules.  It is caused by human papillomavirus infection.  Morphologically there is bowenoid dysplasia present.  Progression to invasive carcinoma is infrequent.


Penile Schwannoma

description: A schwannoma that occurs in the penis.


Myointimoma

description: A rare benign mesenchymal neoplasm that occurs in the glans and corpora of the penis. It is characterized by the proliferation of spindle-shaped myofibroblasts in the intravascular spaces.


Penile Neurofibroma

description: A neurofibroma that occurs in the penis.


name: Basaloid (Undifferentiated) Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by full-thickness replacement of the squamous epithelium by immature, small, monotonous, basophilic cells. The cells have round to oval nuclei, inconspicuous nucleoli, and scant cytoplasm. Apoptosis and mitotic figures are prominent. (WHO 2016)


Stage IV Penile Cancer AJCC v8

description: Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1). T4: Penile cancer with tumor invading into adjacent structures (i.e., scrotum, prostate, pubic bone). N3: Penile cancer with extranodal extension of lymph node metastases or pelvic lymph node metastases. M1: Distant metastasis present. (AJCC 8th ed.)


name: Penile Clear Cell Squamous Cell Carcinoma

description: A variant of penile squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm.


name: Penile Squamous Cell Carcinoma, Not Otherwise Specified

description: A penile squamous cell carcinoma characterized by the absence of special morphologic features and lack of information on p16 immunohistochemistry and human papilloma virus testing status.


name: Warty (Bowenoid) Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by a slightly spiking papillomatous surface with atypical parakeratosis. There is prominent cellular pleomorphism, koilocytosis, and mitoses. Unlike in basaloid penile intraepithelial neoplasia, there is squamous maturation. (WHO 2016)


Stage IIIA Penile Cancer AJCC v8

description: Stage IIIA includes: T1-3, N1, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N1: Penile cancer with two or less unilateral inguinal metastases, no extranodal extension. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Penile Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Condyloma Acuminatum

description: A human papillomavirus-related benign neoplasm affecting the penis. Most often it arises from the glans penis in young men. It usually presents with a nodular wart. Morphologically, it is characterized by an exophytic papillary proliferation of squamous cells and acanthosis. Most cases either resolve spontaneously or do not recur following removal.


Penile Adenosquamous Carcinoma

description: An extremely rare carcinoma that arises from the penis and is characterized by the presence of glandular and squamous components.


Penile Cancer by AJCC v8 Stage

description: A term that refers to the staging of penile cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to penile squamous cell carcinoma and associated histologic subtypes. It does not apply to urethral carcinomas, sarcomas, and melanomas. (from AJCC 8th Ed.)


name: Unresectable Penile Squamous Cell Carcinoma

description: Penile squamous cell carcinoma that is not amenable to surgical resection.


Penile Cutaneous Melanoma

description: A melanoma that arises from the skin of the penis.


name: Differentiated penile intraepithelial neoplasia

description: Intraepithelial neoplasia of the penis that is not caused by human papillomavirus infection. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present. It is characterized by a thickened epithelium, subtle abnormal cellular maturation, and atypical basal layer cells. Parakeratosis is common. (WHO 2016)


Penile Pseudohyperplastic Carcinoma

description: A multifocal, extremely differentiated squamous cell carcinoma of the penis. It typically occurs in older patients and is associated with lichen sclerosus.


Adult Penile Carcinoma

description: A carcinoma of the penis that occurs during adulthood.


Penile Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that occurs in the penis.


Penile Leiomyoma

description: A leiomyoma that occurs in the penis.


Penile Soft Tissue Neoplasm

description: A rare mesenchymal neoplasm that arises from the penis.


Penile Pseudoglandular Carcinoma

description: A penile squamous cell carcinoma characterized by the formation of gland-like structures.


Stage 0 Penile Cancer AJCC v8

description: Stage 0 includes: 0is: Tis, N0, M0; 0a: Ta, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Penile Cancer AJCC v8

description: Stage IIIB includes: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


name: Human Papillomavirus-Related Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis caused by human papillomavirus infection.


name: Penile Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant peripheral nerve sheath tumor that occurs in the penis.


Penile Papillary-Basaloid Carcinoma

description: A variant of penile basaloid squamous cell carcinoma. It is characterized by a papillary exophytic or endophytic growth pattern.


Stage 0a Penile Cancer AJCC v8

description: Stage 0a includes: Ta, N0, M0. Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Low Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower one third of the epithelial thickness.


Penile Epithelioid Hemangioma

description: An epithelioid hemangioma that occurs in the skin of the penis.


name: High Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy either the lower two thirds of the epithelial thickness (grade II) or the entire thickness of the epithelium (grade III, Bowen atypia, or squamous cell carcinoma in situ).


Stage II Penile Cancer AJCC v8

description: Stage II includes: IIA: (T1b, N0, M0); (T2, N0, M0); IIB: (T3, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Warty-Basaloid Carcinoma

description: A squamous cell carcinoma that arises from the penis. It is characterized by warty (condylomatous) and basaloid features.


Penile Angiosarcoma

description: A rare angiosarcoma that affects the penis.


name: Warty-Basaloid Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by the presence of a variable mixture of warty and basaloid cells. (WHO 2016)


melanoma of penis

description: A melanoma that arises from the penis. It may be cutaneous or mucosal. The most common site of involvement is glans penis.


Metastatic Penile Cancer

description: Carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Stage I Penile Cancer AJCC v8

description: Stage I includes: T1a, N0, M0. T1a: Penile cancer with tumor without lymphovascular invasion or perineural invasion and is not high grade (i.e., grade 3 or sarcomatoid). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Mucoepidermoid Carcinoma

description: An extremely rare carcinoma that arises from the penis and is characterized by the presence of mucinous and squamous components.


Penile Rhabdomyosarcoma

description: A rhabdomyosarcoma that occurs in the penis. It usually affects young children. Embryonal rhabdomyosarcoma is the most common type.


Locally Advanced Penile Carcinoma

description: Penile carcinoma that has spread to nearby tissues or lymph nodes.


Grade 2 Dysphagia, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Symptomatic and altered eating/swallowing


nitrogen-13 atom

The radioactive isotope of nitrogen with relative atomic mass 13.0057386. The longest-lived nitrogen radionuclide with half-life of 9.965 min.


nitrogen-14 atom

The stable isotope of nitrogen with relative atomic mass 14.003074. The most abundant (99.63 atom percent) isotope of naturally occurring nitrogen.


nitrogen-15 atom

The stable isotope of nitrogen with relative atomic mass 15.000109. The least abundant (0.368 atom percent) isotope of naturally occurring nitrogen.


Current Hepatitis B Infection

description: Hepatitis B infection is evident at the time of testing.


name: Grade 3 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Intrapartum Hypoxic Event

description: A sentinel hypoxic event occurring during labor, with evidence of fetal metabolic acidosis in the fetal umbilical arterial blood; a sudden and sustained fetal bradycardia or the absence of fetal heart rate variability in the presence of persistent, late, or variable decelerations (category III tracing); previously normal Apgar scores that are 0-3 beyond 5 minutes.


Stage IIIB Anal Cancer AJCC v8

description: Stage IIIB includes: T4, N0, M0. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Postoperative Hemorrhage

description: Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related.


Grade 2 Proteinuria, CTCAE

description: Adult: 2+ and 3+ proteinuria; urinary protein 1.0-<3.5 g/24 hrs; Pediatric: Urine P/C (Protein/Creatinine) ratio 0.5-1.9


Grade 3 Proteinuria, CTCAE

description: Adult: Urinary protein >=3.5 g/24 hrs; 4+ proteinuria; Pediatric: Urine P/C (Protein/Creatinine) ratio >1.9


Grade 1 Proteinuria, CTCAE

description: 1+ proteinuria; urinary protein > or = to ULN-<1.0 g/24 hrs


name: Uterine Corpus Spindle Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic spindle cells.


description: A rare serous cystadenocarcinoma that arises from the paratesticular structures.


D-threonine

An optically active form of threonine having D-configuration.


name: Fumarate Hydratase-Deficient Renal Cell Carcinoma

description: A rare, highly aggressive renal cell carcinoma caused by germline or (in a subset) somatic mutation of fumarate hydratase gene. It arises mostly in the setting of hereditary leiomyomatosis-renal cell carcinoma syndrome.


Grade 3 Encephalitis Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities


Acephalostomia

description: A congenital defect characterized by the absence of most or all of the head, with the presence of a mouth-like opening on the upper thorax.


Grade 1 Colonic Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Hemorrhoidal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Myositis, Proliferative

description: A rapidly growing, poorly circumscribed, mass-forming proliferation that arises from the skeletal muscle. It is characterized by the presence of spindle-shaped fibroblasts, round ganglion-like cells, myxoid to collagenous stroma formation, and high mitotic activity. It recurs only rarely following local excision and does not metastasize.


Vascular Access Complication, CTCAE

description: A finding of a previously undocumented problem related to the vascular access site.


name: Grade 1 Vascular Access Complication, CTCAE

description: TPA administration into line with no intent for systemic therapy indicated


name: Grade 3 Vascular Access Complication, CTCAE

description: Pulmonary embolism, deep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure)


name: Grade 2 Vascular Access Complication, CTCAE

description: Device dislodgement, blockage, leak, or malposition; device replacement indicated


name: Grade 5 Vascular Access Complication, CTCAE

description: Death


name: Grade 4 Vascular Access Complication, CTCAE

description: Life-threatening consequences with hemodynamic or neurologic instability


name: Grade 4 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatic Beta Cell Adenoma

description: An adenoma arising from the beta cells of the pancreas.  It produces insulin.


Carcinoma of lower gum

description: A carcinoma of the oral cavity that arises from the lower gingiva.


Carcinoma of upper gum

description: A carcinoma of the oral cavity that arises from the upper gingiva.


Gingival Spindle Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma that arises from the gingiva. It is characterized by the presence of malignant pleomorphic spindle cells.


Gingival Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the gingival mucosa. It presents as an ulcerated lesion or exophytic mass. The prognosis is usually poor.


Gingival Angiofibroma

description: A benign neoplasm arising from the fibrous soft tissues of the gingiva. It is characterized by the presence of spindle-shaped fibroblasts and numerous dilated vascular channels.


squamous cell carcinoma of lower gum

description: A squamous cell carcinoma of the oral cavity that arises from the lower gingiva.


carcinoma of gingiva

description: A carcinoma of the oral cavity that arises from the upper or lower gingiva.


squamous cell carcinoma of upper gum

description: A squamous cell carcinoma of the oral cavity that arises from the upper gingiva.


name: Retromolar Trigone Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the retromolar trigone. Pain, often radiating to the ear, is the presenting symptom. The prognosis is poor.


name: Paranasal sinus teratocarcinosarcoma (type)

description: A malignant sinonasal neoplasm with combined histological features of teratoma and carcinosarcoma, lacking malignant germ cell components. (WHO 2017)


carcinosarcoma of salivary gland

description: An aggressive, high grade malignant tumor that arises from the salivary gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Lacrimal Gland Carcinosarcoma

description: An aggressive, high grade malignant neoplasm that arises from the lacrimal gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Pleomorphic adenoma of parotid gland

description: A benign, slow-growing tumor that arises from the parotid gland.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin and women are more often affected than men.


name: Recurrent Childhood Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma in childhood after a period of remission.


name: Malignant Mixed Tumor of the Major Salivary Gland

description: A malignant tumor arising from the parotid gland, submandibular gland, or sublingual gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Conjunctival Adenosquamous Carcinoma

description: A carcinoma that arises from the conjunctiva. It is characterized by the presence of a variable combination of squamous (epidermoid) cells and mucous cells, arranged in invasive sheets, cords, and ducts. (WHO 2018)


name: Stage III Uterine Corpus Adenosarcoma AJCC v8

description: Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Adenocarcinoma with cartilaginous and osseous metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive cartilage and/or bone formation.


Recurrent Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma after a period of remission.


Uterine Carcinosarcoma, Homologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements that arise from the tissues of the uterus.


name: Uterine Corpus Adenosarcoma by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus adenosarcoma according to the American Joint Committee on Cancer, 8th edition.


name: Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component.


name: Metastatic Endometrial Adenosquamous Carcinoma

description: Endometrial adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: mixed acinar-endocrine carcinoma of pancreas

description: A carcinoma that arises from the pancreas and is composed of acinar carcinoma and neuroendocrine carcinoma components in both the primary tumor and the metastatic sites.


name: Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm

description: A neoplasm that arises from the cervix and is characterized by the presence of benign epithelial and benign mesenchymal elements. This category includes adenofibroma and adenomyoma.


Primary peritoneal carcinosarcoma

description: An extremely rare and highly aggressive malignant neoplasm arising from the peritoneum.  Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.


Hybrid Salivary Gland Tumor

description: A rare neoplasm that arises from the salivary gland and consists of at least two histologically distinct types of tumor within the same topographic location. The tumor components can be either benign or malignant.


name: Uterine Carcinosarcoma, Heterologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements composed of tissues that are not found in the uterus (e.g., bone, cartilage, skeletal muscle).


name: Appendix Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the appendix.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Metastasizing Pleomorphic Adenoma of the Salivary Gland

description: A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features.  The most common sites of metastasis are bone, lung, and head and neck.


Oropharyngeal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the oropharynx.


name: Stage IIIA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Borderline Serous Cystadenofibroma

description: A neoplasm of low malignant potential arising from a site in the female reproductive system. Almost all cases have been reported in the ovary. It is characterized by the presence of cystic spaces which are lined by atypical serous epithelial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion.


Advanced Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIC Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Advanced Malignant Mixed Mesodermal (Mullerian) Tumor

description: A malignant mixed mesodermal (Mullerian) tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage I Uterine Corpus Adenosarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Metastatic Cervical Adenosquamous Carcinoma

description: A cervical adenosquamous carcinoma that has spread to another anatomic site.


name: Testicular Mixed Choriocarcinoma and Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Metastatic Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Squamous Cell Carcinoma with Sarcomatoid Differentiation

description: A rare carcinoma of the skin characterized by the presence of squamous cell carcinomatous and sarcomatous components.


Sellar Mixed Germ Cell Tumor

description: A mixed germ cell tumor that arises from or adjacent to the sellar region.


Cellular Pleomorphic Adenoma

description: A pleomorphic adenoma with increased cellularity.


name: Metastatic Vaginal Adenosquamous Carcinoma

description: Vaginal adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Anal Canal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the anal canal.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Recurrent Childhood Oligoastrocytoma

description: The reemergence of oligoastrocytoma in childhood after a period of remission.


Hard Palate Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the hard palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


carcinosarcoma of gallbladder

description: A carcinoma that arises from the gallbladder and it is characterized by the presence of a sarcomatous component.  The sarcomatous component may contain osteosarcoma, chondrosarcoma, or rhabdomyosarcoma elements.


name: Mixed neuroendocrine-non neuroendocrine neoplasm

description: A rare neoplasm that consists of neuroendocrine and non-neuroendocrine cellular components. At least 30% of either component should be present for the diagnosis to be made.


name: Metastatic Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread from its original site of growth to another anatomic site.


name: Pancreatic Mixed Ductal Adenocarcinoma-Neuroendocrine Tumor

description: A very rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine tumor component.


name: Testicular Mixed Embryonal Carcinoma and Teratoma

description: A malignant mixed germ cell tumor arising from the testis, characterized by the presence of an embryonal carcinomatous component and a teratomatous component.


name: Gallbladder Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the gallbladder and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Sinonasal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the sinonasal tract.


Metastatic Carcinosarcoma

description: Carcinosarcoma that has spread from its original site of growth to another anatomic site.


Recurrent Fallopian Tube Carcinosarcoma

description: The reemergence of fallopian tube carcinosarcoma after a period of remission.


Hybrid Salivary Gland Carcinoma

description: A rare carcinoma that arises from the salivary gland and consists of at least two histologically distinct types of carcinoma within the same topographic location. The carcinoma components usually are adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, and/or salivary duct carcinoma. Adenoid cystic carcinoma is commonly the predominant component.


Adult Mixed Glioma

description: A mixed glioma that occurs during adulthood.


Malignant chondroid syringoma

description: A rare malignant skin neoplasm that arises from a benign mixed tumor of the skin (chondroid syringoma).


Uterine Ligament Adenomyoma

description: A benign neoplasm that arises from the broad or other uterine ligaments. It is characterized by the presence of a glandular and a mesenchymal component.


name: Testicular Mixed Choriocarcinoma and Embryonal Carcinoma

description: A malignant mixed germ cell tumor that arises from the testis and is characterized by the presence of choriocarcinoma and embryonal carcinoma morphologic components.


name: Stage IIIB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Mixed parotid tumor

description: A benign or malignant neoplasm that arises from the parotid gland.  It is characterized by the presence of epithelial and mesenchymal elements.  This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma.


name: Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal-Type

description: A very rare testicular germ cell tumor that combines teratoma and yolk sac tumor. It usually affects young children. It is not associated with chromosome 12p amplification or germ cell neoplasia in situ.


Childhood Oligoastrocytoma

description: An oligoastrocytoma that occurs during childhood.


name: Gastric Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the stomach and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma

description: A carcinoma that arises from a pleomorphic adenoma in the minor salivary glands.  Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months.  Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis.  In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Oral Cavity Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the salivary glands in the oral cavity.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


name: Stage IA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus adenosarcoma with tumor limited to the endometrium/endocervix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and yolk sac tumor morphologic elements.  Patients may present with painless or painful testicular swelling.


Recurrent Oligoastrocytoma

description: The reemergence of oligoastrocytoma after a period of remission.


name: Pancreatic Mixed Ductal-Neuroendocrine Neoplasm

description: A rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine neoplastic component. The latter is usually a poorly differentiated neuroendocrine carcinoma and rarely a well differentiated neuroendocrine tumor.


name: Testicular Mixed Yolk Sac Tumor and Teratoma

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac and teratomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Malignant Submandibular Gland Mixed Tumor

description: A malignant tumor arising from the submandibular gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


name: Benign Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm

description: A non-metastasizing neoplasm that arises from the uterine corpus and is composed of epithelial and mesenchymal elements. Representative examples include adenomyoma and adenofibroma.


name: Testicular Mixed Yolk Sac Tumor and Teratoma with Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac, teratomatous, and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Mixed Carcinoma

description: A carcinoma characterized by the presence of more than one malignant epithelial histologic pattern.


name: Stage IVB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Recurrent Cervical Adenosquamous Carcinoma

description: The reemergence of cervical adenosquamous carcinoma after a period of remission.


name: Stage IB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Uterine corpus adenosarcoma with tumor invading to less than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Primary Peritoneal Carcinosarcoma

description: The reemergence of primary peritoneal carcinosarcoma after a period of remission.


name: Malignant Mixed Tumor, Not Otherwise Specified

description: A malignant myoepithelioma characterized by the presence of a minor ductal component.


Childhood Anaplastic Oligoastrocytoma

description: An anaplastic oligoastrocytoma that occurs during childhood.


Childhood Breast Fibroadenoma

description: A fibroadenoma that arises from the breast and occurs during childhood.


name: Ampulla of Vater Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the ampulla of Vater and the periampullary region. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Childhood Mixed Glioma

description: A mixed glioma that occurs during childhood.


name: Stage II Uterine Corpus Adenosarcoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


adenosquamous carcinoma of tongue

description: A rare adenosquamous carcinoma that arises from the tongue.


name: Testicular Mixed Embryonal Carcinoma and Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma and a seminomatous component.


name: Refractory Uterine Corpus Carcinosarcoma

description: Uterine Corpus Carcinosarcoma that is resistant to treatment.


Advanced Carcinosarcoma

description: Carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Choriocarcinoma combined with other germ cell elements

description: A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous component admixed with another germ cell component (e.g. embryonal carcinoma, teratoma, or seminoma).


name: Recurrent Endometrial Adenosquamous Carcinoma

description: The reemergence of endometrial adenosquamous carcinoma after a period of remission.


name: Malignant Vaginal Mixed Tumor Resembling Synovial Sarcoma

description: A very rare malignant mixed epithelial and mesenchymal neoplasm that arises from the vagina and resembles synovial sarcoma.  It is characterized by a biphasic pattern and is composed of gland-like structures that are lined by epithelial cells and a cellular mesenchymal component.


Malignant Parotid Gland Mixed Tumor

description: A malignant tumor arising from the parotid gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Odontogenic Carcinosarcoma

description: An extremely rare malignant mixed odontogenic neoplasm in which both the epithelial and the mesenchymal components are cytologically malignant. (WHO 2017)


name: Advanced Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Invasive Bladder Mixed Carcinoma

description: An invasive bladder carcinoma characterized by the presence of more than one histologic pattern.


name: Human Papillomavirus-Related Adenosquamous Carcinoma

description: An adenosquamous carcinoma associated with the presence of human papillomavirus infection.


name: Esophageal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the esophagus and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Vaginal Adenosquamous Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of malignant glandular and malignant squamous epithelial components.


Laryngeal Pleomorphic Adenoma

description: A very rare pleomorphic adenoma that arises from the larynx.


name: Stage IVA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Mixed Tumor, Not Otherwise Specified

description: A benign myoepithelioma characterized by the presence of a minor ductal component.


name: Vulvar Composite Hidradenoma Papilliferum and Fibroadenoma

description: A benign composite neoplasm that arises from the vulva and is characterized by mixed histopathologic features of hidradenoma papilliferum and fibroadenoma.


name: Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of embryonal carcinoma and yolk sac morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Pancreatic Mixed Acinar-Ductal Neuroendocrine Carcinoma

description: A very rare carcinoma that arises from the pancreas and is composed of ductal adenocarcinoma, acinar carcinoma, and neuroendocrine carcinoma components.


Trichoblastic carcinosarcoma

description: A rare biphasic follicular neoplasm consisting of a malignant epithelial component resembling follicular germinative cells closely associated with a malignant stromal component differentiating towards specific follicular mesenchyme. (WHO 2018)


name: Metastatic Digestive System Mixed Adenoneuroendocrine Carcinoma

description: Mixed adenoneuroendocrine carcinoma that arises from the digestive system and has metastasized to other anatomic sites.


Hybrid nerve sheath tumor

description: A benign nerve sheath tumor characterized by the combination of histologic features seen in schwannomas, neurofibromas, and perineuriomas.


Pleomorphic adenoma of lacrimal gland

description: A benign, usually encapsulated neoplasm of the lacrimal gland composed of epithelial and mesenchymal cells.  Pleomorphic adenomas are neoplasms that develop in the salivary glands or heterotopic salivary gland tissues.  It has been suggested that myoepithelial cells play a major role in the histogenesis of these tumors.  In the lacrimal gland, pleomorphic adenomas presumably develop from metaplastic myoepithelial cells.


name: Malignant Mixed Tumor of the Minor Salivary Gland

description: A malignant tumor arising from the minor salivary glands.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


name: Seminal Vesicle Mixed Epithelial and Stromal Tumor

description: A rare biphasic neoplasm that arises from the seminal vesicle. It is characterized by the presence of stromal and benign epithelial components. Rarely, the stromal component may display atypia and mitotic activity and the tumor may behave in a malignant clinical course.


Soft Palate Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the soft palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


Breast Pleomorphic Adenoma

description: A rare, benign and well circumscribed neoplasm that arises from the breast.  It is characterized by the proliferation of epithelial and myoepithelial cells surrounded by chondroid stroma.


name: Stage IC Uterine Corpus Adenosarcoma AJCC v8

description: Stage IC includes: T1c, N0, M0. T1c: Uterine corpus adenosarcoma with tumor invading more than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IV Uterine Corpus Adenosarcoma AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Metastatic Malignant Mixed Mesodermal (Mullerian) Tumor

description: A malignant mixed mesodermal (Mullerian) tumor that has spread from its original site of growth to another anatomic site.


Recurrent Uterine Corpus Carcinosarcoma

description: The reemergence of uterine corpus carcinosarcoma after a period of remission.


Parotid Gland Carcinosarcoma

description: An aggressive, high grade malignant tumor that arises from the parotid gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


name: Gallbladder Mucinous Cystic Neoplasm, High Grade

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of severe atypia.


name: Adenocarcinoma of anogenital mammary-like glands

description: A primary invasive malignant epithelial neoplasm of the vulva showing morphological features of recognized breast adenocarcinomas. (WHO, 2014)


Vulvar Adenocarcinoma, Intestinal-Type

description: A rare vulvar mucinous adenocarcinoma that resembles a large intestinal adenocarcinoma.


name: Grade 2 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Left Ventricular Diastolic Dysfunction, CTCAE


biotins

Compounds containing a biotin (5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid) skeleton.


A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.


name: Grade 3 Peripheral Motor Neuropathy, CTCAE

description: Severe symptoms; limiting self care ADL


Grade 1 Testicular Pain, CTCAE

description: Mild pain


Grade 3 Bladder Spasm, CTCAE

description: Hospitalization indicated


Grade 3 Venous Injury, CTCAE

description: Severe symptoms; limiting self care ADL; repair or revision indicated


Grade 2 Delayed Orgasm, CTCAE

description: Delay in achieving orgasm adversely affecting relationship


Cervical Squamotransitional Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures with fibrovascular cores. It is covered with multiple layers of atypical cells that resemble cervical intraepithelial neoplasia 3.


name: Grade 2 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


name: Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


name: Grade 3 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


name: Grade 4 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


name: Grade 1 Hearing Patients with or without Baseline Audiogram and Enrolled in a Monitoring Program, CTCAE


name: Grade 3 Salivary Duct Inflammation, CTCAE

description: Acute salivary gland necrosis; severe secretion-induced symptoms (e.g., thick saliva/oral secretions or gagging); tube feeding or TPN indicated; limiting self care ADL


Transformed migraine

description: Episodes of migraine occurring on 15 or more days per month, for more than three months.


name: Grade 4 Cranial Nerve III Neuropathy, CTCAE


description: A reactive proliferation of the conjunctival epithelium associated with the presence of prominent glandular elements.


Spinal arthritis deformans

description: Degenerative arthritis of the spinal column.


name: Amyotrophic Lateral Sclerosis 14, With or Without Frontotemporal Dementia

description: A form of amyotrophic lateral sclerosis caused by heterozygous mutation(s) in the VCP gene, encoding transitional endoplasmic reticulum ATPase.


Spastic Paraplegia 30

description: An autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the KIF1A gene, encoding kinesin-like protein KIF1A.


Presenile dementia

description: The presence of dementia in an individual younger than age sixty five.


Amyotrophic Lateral Sclerosis 25

description: An autosomal dominant form of amyotrophic lateral sclerosis caused by mutation(s) in the KIF5A gene, encoding kinesin heavy chain isoform 5A.


Spastic Paraplegia 76

description: An autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the CAPN1 gene, encoding calpain-1 catalytic subunit.


name: Neurodegeneration with Brain Iron Accumulation 2A

description: An autosomal recessive condition caused by mutation(s) in the PLA2G6 gene, encoding 85/88 kDa calcium-independent phospholipase A2. It is characterized by axonal swelling and spheroid bodies in the central nervous system. The onset is typically in the first two years of life.


Grade 3 Gynecomastia, CTCAE

description: Severe symptoms; elective operative intervention indicated


Grade 2 Gynecomastia, CTCAE

description: Symptomatic (e.g., pain or psychosocial impact)


name: Grade 1 Ligament Intra-Operative Injury, CTCAE


name: Unresectable Pancreatic Neuroendocrine Tumor G3

description: Pancreatic neuroendocrine tumor G3 that is not amenable to surgical resection.


Grade 3 Skin Atrophy, CTCAE

description: Covering >30% BSA; associated with ulceration


name: Adult Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11

description: An acute myeloid leukemia with inv(16)(p13.1q22); CBFB-MYH11 occurring in adults.


name: Grade 5 Postoperative Thoracic Procedure Complication, CTCAE

description: Death


Grade 2 Arthritis, CTCAE

description: Moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL


name: Musculoskeletal and Connective Tissue Disorders, CTCAE


name: Grade 2 Neck Soft Tissue Necrosis, CTCAE

description: Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Muscle Cramp, CTCAE

description: A disorder characterized by marked cramping sensation originating from a muscle or group of muscles.


name: Grade 3 Muscle Weakness Lower Limb, CTCAE

description: Limiting self care ADL


Grade 3 Arthralgia, CTCAE

description: Severe pain; limiting self care ADL


Arthritis, CTCAE

description: A disorder characterized by inflammation involving a joint.


Grade 1 Avascular Necrosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Unequal Limb Length, CTCAE

description: Severe length discrepancy >5 cm; limiting self care ADL; operative intervention indicated


Grade 3 Scoliosis, CTCAE

description: >45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL


name: Grade 3 Joint Range of Motion Decreased Cervical Spine, CTCAE

description: Ankylosed/fused over multiple segments with no C-spine rotation


name: Grade 3 Muscle Weakness Upper Limb, CTCAE

description: Limiting self care ADL


name: Grade 3 Soft Tissue Necrosis Upper Limb, CTCAE

description: Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


Grade 2 Osteonecrosis of Jaw, CTCAE

description: Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL


Grade 3 Chest Wall Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 4 Soft Tissue Necrosis Upper Limb, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Joint Effusion, CTCAE 5.0

description: A disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation.


Joint Range of Motion Decreased, CTCAE

description: A disorder characterized by a decrease in joint flexibility of any joint.


Grade 1 Pain In Extremity, CTCAE

description: Mild pain


Kyphosis, CTCAE

description: A disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine.


Grade 3 Pain In Extremity, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 2 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 2 Exostosis, CTCAE

description: Symptomatic; limiting instrumental ADL


Trismus, CTCAE

description: A disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication.


Grade 1 Rotator Cuff Injury, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 1 Unequal Limb Length, CTCAE

description: Mild length discrepancy <2 cm


Grade 1 Myositis, CTCAE

description: Mild pain


Rotator Cuff Injury, CTCAE

description: A disorder characterized by an injury of the rotator cuff.


name: Grade 1 Musculoskeletal Deformity, CTCAE

description: Cosmetically and functionally insignificant hypoplasia


Myositis, CTCAE 5.0

description: A disorder characterized by inflammation involving the skeletal muscles.


name: Grade 5 Pelvic Soft Tissue Necrosis, CTCAE

description: Death


Exostosis, CTCAE 5.0

description: A disorder characterized by non-neoplastic overgrowth of bone.


Grade 3 Buttock Pain, CTCAE

description: Severe pain; limiting self care ADL


Muscle Weakness Upper Limb, CTCAE

description: A disorder characterized by a reduction in the strength of the upper limb muscles.


Grade 3 Myalgia, CTCAE

description: Severe pain; limiting self care ADL


Grade 3 Osteoporosis, CTCAE

description: Adult: Loss of height >=2 cm; hospitalization indicated; limiting self care ADL; Pediatric: Limiting self care ADL


Grade 1 Myalgia, CTCAE

description: Mild pain


Grade 4 Rhabdomyolysis, CTCAE

description: Life-threatening consequences; dialysis


Grade 2 Unequal Limb Length, CTCAE

description: Moderate length discrepancy 2-5 cm; shoe lift indicated; limiting instrumental ADL


name: Grade 2 Joint Range of Motion Decreased Lumbar Spine, CTCAE

description: Pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor


Superficial Soft Tissue Fibrosis, CTCAE

description: A disorder characterized by fibrotic degeneration of the superficial soft tissues.


Grade 2 Flank Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 3 Neck Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 3 Head Soft Tissue Necrosis, CTCAE

description: Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


name: Joint Range of Motion Decreased Lumbar Spine, CTCAE

description: A disorder characterized by a decrease in flexibility of a lumbar spine joint.


name: Grade 2 Soft Tissue Necrosis Lower Limb, CTCAE

description: Local wound care; medical intervention indicated (e.g., dressings or topical medications)


name: Grade 1 Muscle Weakness Upper Limb, CTCAE

description: Symptomatic; perceived by patient but not evident on physical exam


Grade 3 Bone Pain, CTCAE

description: Severe pain; limiting self care ADL


Osteoporosis, CTCAE 5.0

description: A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.


Grade 1 Flank Pain, CTCAE

description: Mild pain


name: Grade 1 Joint Range of Motion Decreased Lumbar Spine, CTCAE

description: Stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity


Grade 5 Rhabdomyolysis, CTCAE

description: Death


name: Grade 3 Pelvic Soft Tissue Necrosis, CTCAE


Grade 1 Scoliosis, CTCAE

description: <20 degrees; clinically undetectable


Grade 1 Neck Pain, CTCAE

description: Mild pain


name: Grade 3 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Fibrosis Deep Connective Tissue, CTCAE

description: A disorder characterized by fibrotic degeneration of the deep connective tissues.


name: Grade 3 Joint Range of Motion Decreased Lumbar Spine, CTCAE

description: <50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object)


Grade 1 Chest Wall Pain, CTCAE

description: Mild pain


Grade 4 Osteonecrosis of Jaw, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 3 Osteonecrosis, CTCAE

description: Severe symptoms; limiting self care ADL; elective operative intervention indicated


Lordosis, CTCAE

description: A disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine.


Grade 2 Myositis, CTCAE

description: Moderate pain associated with weakness; pain limiting instrumental ADL


Grade 2 Scoliosis, CTCAE

description: >20-45 degrees; visible by forward flexion; limiting instrumental ADL


Grade 3 Joint Effusion, CTCAE

description: Severe symptoms; limiting self care ADL; invasive intervention indicated


Grade 3 Arthritis, CTCAE

description: Severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; limiting self care ADL


name: Grade 2 Muscle Weakness Upper Limb, CTCAE

description: Symptomatic; evident on physical exam; limiting instrumental ADL


Grade 2 Avascular Necrosis, CTCAE

description: Symptomatic; limiting instrumental ADL


name: Grade 1 Generalized Muscle Weakness, CTCAE


name: Grade 4 Neck Soft Tissue Necrosis, CTCAE


Grade 1 Exostosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Buttock Pain, CTCAE

description: Mild pain


name: Grade 2 Pelvic Soft Tissue Necrosis, CTCAE


name: Grade 5 Superficial Soft Tissue Fibrosis, CTCAE

description: Death


name: Grade 1 Joint Range of Motion Decreased, CTCAE

description: <=25% loss of ROM (range of motion); decreased ROM limiting athletic activity


Grade 1 Osteoporosis, CTCAE

description: Adult: Radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); Pediatric: Radiologic evidence of low BMD with z score of <= -2.0 and no history of significant fractures


name: Grade 1 Muscle Weakness Lower Limb, CTCAE

description: Symptomatic; perceived by patient but not evident on physical exam


Grade 1 Growth Suppression, CTCAE

description: Reduction in growth velocity by 10-29% ideally measured over the period of a year


name: Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE


name: Grade 4 Head Soft Tissue Necrosis, CTCAE


name: Grade 4 Superficial Soft Tissue Fibrosis, CTCAE

description: Generalized; associated with signs or symptoms of impaired breathing or feeding


Grade 3 Muscle Cramp, CTCAE

description: Severe pain; limiting self care ADL


Back Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the back region.


name: Grade 2 Soft Tissue Necrosis Upper Limb, CTCAE

description: Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Grade 5 Chest Wall Necrosis, CTCAE

description: Death


Musculoskeletal Deformity, CTCAE

description: A disorder characterized by a malformation of the musculoskeletal system.


Grade 2 Rhabdomyolysis, CTCAE

description: Non-urgent intervention indicated


name: Grade 2 Joint Range of Motion Decreased, CTCAE

description: >25-50% decrease in ROM; limiting instrumental ADL


Grade 3 Rhabdomyolysis, CTCAE

description: Symptomatic, urgent intervention indicated


Grade 5 Osteonecrosis, CTCAE

description: Death


Buttock Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the buttocks.


name: Grade 3 Joint Range of Motion Decreased, CTCAE

description: >50% decrease in ROM; limiting self care ADL


Grade 2 Muscle Cramp, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Grade 1 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Soft Tissue Necrosis Upper Limb, CTCAE

description: A disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity.


name: Grade 2 Superficial Soft Tissue Fibrosis, CTCAE

description: Moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL


Osteonecrosis of Jaw, CTCAE

description: A disorder characterized by a necrotic process occurring in the bone of the mandible.


Grade 1 Trismus, CTCAE

description: Decreased ROM (range of motion) without impaired eating


Grade 3 Myositis, CTCAE

description: Pain associated with severe weakness; limiting self care ADL


Grade 1 Muscle Cramp, CTCAE

description: Mild pain


Grade 1 Bone Pain, CTCAE

description: Mild pain


Grade 3 Flank Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 4 Pelvic Soft Tissue Necrosis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Flank Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort on the lateral side of the body in the region below the ribs and above the hip.


Growth Suppression, CTCAE

description: A disorder characterized by stature that is smaller than normal as expected for age.


name: Grade 5 Fibrosis Deep Connective Tissue, CTCAE

description: Death


Grade 5 Osteonecrosis of Jaw, CTCAE

description: Death


name: Grade 2 Generalized Muscle Weakness, CTCAE

description: Symptomatic; evident on physical exam; limiting instrumental ADL


name: Grade 1 Fibrosis Deep Connective Tissue, CTCAE

description: Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)


Unequal Limb Length, CTCAE

description: A disorder characterized by a discrepancy between the lengths of the lower or upper extremities.


name: Grade 5 Soft Tissue Necrosis Lower Limb, CTCAE

description: Death


Myalgia, CTCAE

description: A disorder characterized by marked discomfort sensation originating from a muscle or group of muscles.


Neck Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the neck area.


Grade 3 Growth Suppression, CTCAE

description: Reduction in growth velocity of >=50% ideally measured over the period of a year


name: Grade 2 Joint Range of Motion Decreased Cervical Spine, CTCAE

description: Rotation <60 degrees to right or left; <60 degrees of flexion


Grade 2 Kyphosis, CTCAE

description: Moderate accentuation; limiting instrumental ADL


name: Grade 3 Soft Tissue Necrosis Lower Limb, CTCAE

description: Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


Grade 3 Muscle Weakness Trunk, CTCAE

description: Limiting self care ADL


Avascular Necrosis, CTCAE

description: A disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.


name: Grade 5 Soft Tissue Necrosis Upper Limb, CTCAE

description: Death


Grade 1 Joint Effusion, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Osteonecrosis of Jaw, CTCAE

description: Severe symptoms; limiting self care ADL; elective operative intervention indicated


name: Grade 3 Abdominal Soft Tissue Necrosis, CTCAE


Grade 2 Back Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Pelvic Soft Tissue Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the soft tissues of the pelvis.


Pain In Extremity, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the upper or lower extremities.


Grade 5 Avascular Necrosis, CTCAE

description: Death


name: Grade 2 Muscle Weakness Lower Limb, CTCAE


Grade 4 Avascular Necrosis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Abdominal Soft Tissue Necrosis, CTCAE

description: Death


name: Grade 4 Soft Tissue Necrosis Lower Limb, CTCAE


Chest Wall Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the chest wall.


name: Grade 2 Abdominal Soft Tissue Necrosis, CTCAE

description: Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Grade 3 Rotator Cuff Injury, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Muscle Weakness Trunk, CTCAE

description: A disorder characterized by a reduction in the strength of the trunk muscles.


Generalized Muscle Weakness, CTCAE

description: A disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.


Grade 3 Back Pain, CTCAE

description: Severe pain; limiting self care ADL


Soft Tissue Necrosis Lower Limb, CTCAE

description: A disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity.


name: Grade 4 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE


name: Grade 5 Neck Soft Tissue Necrosis, CTCAE

description: Death


Chest Wall Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the soft tissues of the chest wall including breast.


Grade 2 Rotator Cuff Injury, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL


name: Grade 3 Fibrosis Deep Connective Tissue, CTCAE

description: Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


Muscle Weakness Lower Limb, CTCAE

description: A disorder characterized by a reduction in the strength of the lower limb muscles.


Grade 2 Growth Suppression, CTCAE

description: Reduction in growth velocity by 30-49% ideally measured over the period of a year or 0-49% reduction in growth from the baseline growth curve


Abdominal Soft Tissue Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall.


Grade 1 Rhabdomyolysis, CTCAE

description: Asymptomatic, intervention not indicated; laboratory findings only


Grade 1 Lordosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Arthralgia, CTCAE

description: A disorder characterized by a sensation of marked discomfort in a joint.


Grade 2 Osteoporosis, CTCAE

description: Adult: BMD t-score < -2.5; loss of height <2 cm; therapy to improve BMD indicated; limiting instrumental ADL; Pediatric: Low BMD (z-score <= -2.0) and significant fracture history (defined as a long bone fracture of the lower extremity, vertebral compression, 2 or more long bone fractures of the upper extremities); therapy to improve BMD indicated


name: Grade 3 Generalized Muscle Weakness, CTCAE

description: Limiting self care ADL


Grade 3 Avascular Necrosis, CTCAE

description: Severe symptoms; limiting self care ADL; elective operative intervention indicated


name: Grade 4 Fibrosis Deep Connective Tissue, CTCAE

description: Generalized; associated with signs or symptoms of impaired breathing or feeding


Grade 2 Chest Wall Necrosis, CTCAE

description: Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Rhabdomyolysis, CTCAE

description: A disorder characterized by the breakdown of muscle tissue resulting in the release of muscle fiber contents into the bloodstream.


name: Grade 4 Abdominal Soft Tissue Necrosis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 2 Muscle Weakness Trunk, CTCAE

description: Symptomatic; evident on physical exam; limiting instrumental ADL


Bone Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the bones.


Scoliosis, CTCAE

description: A disorder characterized by a malformed, lateral curvature of the spine.


Grade 1 Back Pain, CTCAE

description: Mild pain


Grade 3 Lordosis, CTCAE

description: Severe accentuation; operative intervention indicated; limiting self care ADL


name: Joint Range of Motion Decreased Cervical Spine, CTCAE

description: A disorder characterized by a decrease in flexibility of a cervical spine joint.


Grade 2 Osteonecrosis, CTCAE

description: Symptomatic; medical intervention indicated (e.g., analgesics or bisphosphonates); limiting instrumental ADL


Grade 3 Chest Wall Necrosis, CTCAE

description: Operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting)


Neck Soft Tissue Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the soft tissues of the neck.


Head Soft Tissue Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the soft tissues of the head.


Grade 1 Arthritis, CTCAE

description: Mild pain with inflammation, erythema, or joint swelling


name: Grade 5 Head Soft Tissue Necrosis, CTCAE

description: Death


Grade 2 Lordosis, CTCAE

description: Moderate accentuation; limiting instrumental ADL


name: Grade 1 Joint Range of Motion Decreased Cervical Spine, CTCAE

description: Mild restriction of rotation or flexion between 60-70 degrees


name: Grade 3 Musculoskeletal Deformity, CTCAE

description: Significant deformity, hypoplasia, or asymmetry, unable to be remediated by prosthesis or covered by clothing; limiting self care ADL


name: Grade 1 Superficial Soft Tissue Fibrosis, CTCAE

description: Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)


Grade 1 Arthralgia, CTCAE

description: Mild pain


Grade 2 Joint Effusion, CTCAE

description: Symptomatic; limiting instrumental ADL


Grade 2 Bone Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Grade 5 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE

description: Death


Grade 5 Vaginal Hemorrhage, CTCAE

description: Death


Grade 2 Lip Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Moniliform hamartoma

description: A type of pilosebaceous hamartoma characterized by the development of a linear, flesh colored, fine papular eruption on the head, neck and upper chest after puberty.


Apocrine Sweat Gland Hamartoma

description: A hamartoma characterized by localized apocrine sweat gland malformation.


name: Recurrent Endometrial Undifferentiated Carcinoma

description: The reemergence of endometrial undifferentiated carcinoma after a period of remission.


name: Metastatic Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that has spread from its original site of growth to another anatomic site.


name: Refractory Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that is resistant to treatment.


name: Esophageal Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor that arises from the esophagus.  The majority are spindle cell tumors that exhibit high mitotic activity and affect the distal esophagus.


Grade 4 Retinopathy, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


Grade 2 Wrist Fracture, CTCAE

description: Limiting instrumental ADL; outpatient operative intervention indicated


Grade 2 Neonatal Fever, AE

description: An adverse event in a newborn characterized by fever, minor change in baseline age-appropriate behavior; minor changes in care (e.g. environmental settings, symptomatic treatment).


name: Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVB Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip and oral cavity cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7


name: Stage IVB Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


name: Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip and oral cavity cancer with very advanced local disease. Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVB Oral Cavity Cancer AJCC v6 and v7


Stage IVB Lip Cancer AJCC v6 and v7

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Lip cancer with very advanced local disease.  Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Grade 1 Oropharyngeal Pain, CTCAE

description: Mild pain


Grade 2 Premature Menopause, CTCAE

description: Present


name: Grade 5 Pharynx Obstruction and Stenosis, CTCAE


name: Pathologic Stage IB Cutaneous Melanoma AJCC v8

description: Stage IB includes: T2a, N0, M0. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Vein of Galen Malformations

description: An arteriovenous malformation in the vein of Galen that is located at the base of the brain. The malformation may result in developmental delays, hydrocephalus, seizures, and congestive heart failure.


Grade 1 Tracheal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Dextro-Transposition of the Great Vessels with Ventricular Septal Defect

description: A congenital heart defect in which there is an abnormal arrangement of any of the primary blood vessels of the heart in conjunction with a pathologic opening between the cardiac ventricles.


Grade 2 Retinopathy of Prematurity, AE

description: An adverse event in a newborn characterized by type 2 prethreshold retinopathy of prematurity (ROP) (zone 1 International Classification of Retinopathy of Prematurity (ICROP) stage 1 or 2 without plus disease; zone 2 ICROP stage 3 without plus disease); requiring more frequent ophthalmic monitoring.


name: Grade 2 Intestinal Stoma Obstruction, CTCAE

description: Self-limited; intervention not indicated


Grade 4 Retinal Detachment, CTCAE

description: Macula-off rhegmatogenous retinal detachment


Retinal Detachment, CTCAE 5.0

description: A disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium.


Grade 3 Retinal Detachment, CTCAE

description: Macular sparing rhegmatogenous detachment


Stage II Low-CSD Melanoma AJCC v7

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Ed.)


name: Stage II Cutaneous Melanoma AJCC v6 and v7

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


name: Stage II Lentigo Maligna Melanoma AJCC v6 and v7


name: Stage IIC Cutaneous Melanoma AJCC v6 and v7

description: Stage IIC includes: T4b, N0, M0.  T4b: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


name: Stage IIB Cutaneous Melanoma AJCC v6 and v7

description: Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0).  T3b: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, with ulceration.  T4a: Cutaneous melanoma with a tumor measuring more than 4.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


name: Stage IIA Cutaneous Melanoma AJCC v6 and v7

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, with ulceration.  T3a: Cutaneous melanoma with a tumor measuring 2.01-4.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 6th and 7th Eds.)


name: Grade 4 Thrombosis or Embolism Vascular Access Related, CTCAE


name: Grade 5 Non-Malignant Pleural Effusion, CTCAE


name: Grade 5 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Retroperitoneal Hemorrhage, CTCAE

description: Death


Atypical Vascular Proliferation

description: Benign vascular proliferations following external radiation. The lesions present in adults, predominantly in elderly women following radiotherapy for breast carcinoma. They arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. Identical lesions can occur after radiation for cervical carcinoma, endometrial carcinoma, ovarian carcinoma, Hodgkin lymphoma, and melanoma. There is an increased risk for subsequent development of angiosarcoma.


Atypical Vascular Lesion of Breast

description: Benign vascular proliferations following external radiation for breast carcinoma. The lesions arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. There is an increased risk for subsequent development of angiosarcoma.


name: Advanced Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 4 Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


inorganic peroxide

Compounds of structure ROOR' in which R and R' are inorganic groups.


maghemite

An iron oxide mineral with formula Fe2O3 formed by weathering of spinels containing iron(II) such as magnetite or titanomagnetite, or through dehydration and transformation of some iron oxyhydroxide minerals. A brown or yellow pigment found in various sediments and soils.


hematite nanoparticle

An iron oxide nanoparticle composed of hematite (Fe2O3).


maghemite nanoparticle

A superparamagnetic iron oxide nanoparticle consisting of maghemite, Fe2O3.


silicon dioxide nanoparticle

A nanoparticle consisting of silicon dioxide.


name: Bladder squamous cell carcinoma recurrent

description: The reemergence of bladder squamous cell carcinoma after a period of remission.


name: Recurrent Non-Muscle Invasive Bladder Carcinoma

description: The reemergence of non-muscle invasive bladder carcinoma after a period of remission.


name: Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma

description: The reemergence of non-muscle invasive bladder urothelial carcinoma after a period of remission.


name: Recurrent Muscle Invasive Bladder Urothelial Carcinoma

description: The reemergence of muscle invasive bladder urothelial carcinoma after a period of remission.


name: Recurrent Bladder Small Cell Neuroendocrine Carcinoma

description: The reemergence of bladder small cell neuroendocrine carcinoma after a period of remission.


Bladder adenocarcinoma recurrent

description: A recurrence of adenocarcinoma of the bladder after a period of remission.


Urothelial carcinoma bladder recurrent

description: The reemergence of bladder urothelial carcinoma after a period of remission.


Grade 3 Arachnoiditis, CTCAE

description: Severe symptoms; limiting self care ADL


name: PERSISTENT MULLERIAN DUCT SYNDROME, TYPE II

description: Persistent Mullerian duct syndrome due to resistance to anti-Mullerian hormone (AMH), resulting from mutations in the AMH receptor (AMHR) gene.


Stage IV Paranasal Sinus Cancer AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Sinonasal Adenocarcinoma, Intestinal-Type with Papillary Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a papillary growth pattern.


name: Stage IVA Lip and Oral Cavity Cancer AJCC v8

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar nerve, floor of mouth, or skin of face (i.e., chin or nose).  T4a (oral cavity): Tumor invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla, or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth socket (alone) by a gingival primary is not sufficient to classify a tumor as T4. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). M0: No distant metastasis. (AJCC 8th Ed.)


name: Metastatic Salivary Gland Squamous Cell Carcinoma

description: Salivary gland squamous cell carcinoma that has spread from the original site of growth to another anatomic site.


name: Recurrent Sinonasal Squamous Cell Carcinoma

description: The reemergence of nasal cavity and paranasal sinus squamous cell carcinoma after a period of remission.


name: Adenoid cystic carcinoma of the oral cavity stage II

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Locally Advanced Oral Cavity Squamous Cell Carcinoma

description: Oral cavity squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVC Lip Cancer AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Lip and Oral Cavity Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of lip and oral cavity carcinoma according to the American Joint Committee on Cancer, 6th and 7th editions.


name: Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage

description: A term that refers to the staging of cutaneous squamous cell carcinoma of the head and neck according to the American Joint Committee on Cancer, 8th edition.


Lip basal cell carcinoma

description: A basal cell carcinoma arising from the lip.


Unresectable Head and Neck Carcinoma

description: Carcinoma that arises from the head and neck region and is not amenable to surgical resection.


name: Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Locally Recurrent Head and Neck Squamous Cell Carcinoma

description: The reemergence of head and neck squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Sinonasal Spindle Cell Squamous Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma arising from the sinonasal tract. It is characterized by the presence of malignant cells with spindle cell features.


name: Lower Alveolar Ridge Squamous Cell Carcinoma

description: Squamous cell carcinoma arising from the lower alveolar ridge.


name: Stage I Nasal Cavity Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1:Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


SMARCB1-Deficient Sinonasal Carcinoma

description: An SWI/SNF-deficient sinonasal carcinoma characterized by biallelic deletion or inactivating mutation of SMARCB1 gene. It usually affects the paranasal sinuses, especially ethmoid. It is composed of a monomorphic malignant epithelial cellular population with a predominantly basaloid or plasmacytoid/rhabdoid morphology.


name: External Auditory Canal Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the keratinizing squamous epithelium that lines the external auditory canal.


Salivary Gland Secretory Carcinoma

description: A rare, low-grade carcinoma of the salivary gland with favorable clinical outcome.  It usually arises from the parotid gland and less often from the minor salivary glands.  It shares the same histopathologic features and molecular characteristics (ETV6 gene rearrangement) with secretory breast carcinoma.


name: Sinonasal Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the nasal cavity and paranasal sinuses.


Hard Palate Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma arising from the minor salivary glands in the hard palate.


description: An adenocarcinoma that arises from the nasal cavity and paranasal sinuses. Histologically it resembles intestinal adenocarcinoma. It is associated with lengthy occupational exposure to dust.


name: Ameloblastic Carcinoma Derived From Odontogenic Cyst

description: A rare, aggressive malignant tumor that originates from an odontogenic cyst in the maxillomandibular region.  It combines the histologic features of an ameloblastoma and carcinoma.


description: Adenocarcinomas that arise from the nasal cavity and paranasal sinuses and do not resemble salivary gland adenocarcinomas. This category includes intestinal-type and non-intestinal type adenocarcinomas.


Recurrent Lip and Oral Cavity Carcinoma

description: The reemergence of lip and/or oral cavity carcinoma after a period of remission.


Metastatic Salivary Gland Carcinoma

description: A salivary gland carcinoma that has metastasized to another anatomic site.


name: Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor 4 cm or larger in greatest dimension or minor bone erosion or perineural invasion or deep invasion. Deep invasion is defined as invasion beyond the subcutaneous fat or larger than 6 mm; perineural invasion for T3 classification is defined as tumor cells within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm or larger in caliber, or presenting with clinical or radiographic involvement of named nerves without skull base invasion or transgression. T1: Tumor smaller than 2 cm in greatest dimension.  T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


Carcinoma of base of tongue

description: A carcinoma that arises from the base of the tongue.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


name: Stage I Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage IV Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension. N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Head and Neck Merkel Cell Carcinoma

description: Merkel cell carcinoma that arises from the head and neck region. It usually arises from sun-exposed skin. Rare cases arising from the oral cavity and salivary glands have been reported.


name: Paranasal Sinus Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the paranasal sinuses.


name: Paranasal Sinus Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that arises from the paranasal sinuses.


name: Primary Intraosseous Squamous Cell Carcinoma Derived From Keratocystic Odontogenic Tumor

description: A rare primary intraosseous carcinoma, not otherwise specified, that arises from the lining of an odontogenic keratocyst.


name: Head and Neck Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the head and neck.


name: Upper Alveolar Ridge Squamous Cell Carcinoma

description: Squamous cell carcinoma arising from the upper alveolar ridge.


Advanced Head and Neck Carcinoma

description: A head and neck carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Posterior Tongue Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the base of the tongue.  It usually presents as a painful ulcerated lesion.


name: Sinonasal Human Papillomavirus-Related Carcinoma with Adenoid Cystic-Like Features

description: A distinctive HPV-related non-keratinizing squamous cell carcinoma of the sinonasal tract arising most frequently from the maxillary sinus or nasal cavity. Most patients present with nasal obstruction and/or epistaxis. It is characterized by the presence of basaloid cell proliferations separated by collagenous fibrous bands. The basaloid cells align around microcystic spaces.


name: Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Anterior Tongue Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma arising from the minor salivary glands in the anterior tongue.


name: Unresectable Oral Cavity Squamous Cell Carcinoma

description: Oral cavity squamous cell carcinoma that is not amenable to surgical resection.


name: Squamous cell carcinoma of head and neck metastatic

description: A head and neck squamous cell carcinoma which has spread from the original site of growth to another anatomic site.


name: Stage IV Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal NUT Carcinoma

description: A highly aggressive, poorly differentiated carcinoma that arises from the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene.


Sclerosing Odontogenic Carcinoma

description: A rare, low-grade primary intraosseous carcinoma of the jaws, with bland cytology, markedly sclerotic stroma, and aggressive infiltration. It is characterized by single-file thin cords, nests, and strands of epithelium in a densely sclerotic stroma. Cytologically, individual epithelial cells are bland, with infrequent mitoses. Their cytoplasm may show vacuolation or partial clearing. There is no squamous differentiation. Despite the benign appearance, there is invasion of skeletal muscle, and perineural infiltration is characteristic. (WHO 2017)


name: Sinonasal Poorly Differentiated Carcinoma

description: A poorly differentiated carcinoma that arises from the nasal cavity and/or paranasal sinuses.


name: Stage IVA Oral Cavity Cancer AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Adenoid cystic carcinoma of the oral cavity stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Salivary Gland Low Grade Adenocarcinoma, Not Otherwise Specified

description: A salivary gland adenocarcinoma, not otherwise specified, characterized by the presence of low-grade morphological features.


name: Metastatic Oral Cavity Squamous Cell Carcinoma

description: A squamous cell carcinoma of the oral cavity which has spread from the original site of growth to another anatomic site.


Sinonasal Cancer by AJCC v8 Stage

description: A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 8th edition.


Metastatic Oral Cavity Carcinoma

description: A carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Ghost Cell Odontogenic Carcinoma

description: A carcinoma usually arising from the maxilla and less often the mandible.  Symptoms include swelling and paresthesia.  It is characterized by the presence of rounded islands of malignant epithelial cells in a fibrous stroma and the benign features of calcifying cystic odontogenic tumor.  The clinical course varies from slow growing and locally invasive to rapidly growing and highly aggressive with metastases.