name: Minor Salivary Gland Small Cell Neuroendocrine Carcinoma

description: An infrequent small cell carcinoma that arises from a minor salivary gland. It is characterized by the presence of neuroendocrine differentiation and a high number of mitotic figures.


Recurrent Salivary Gland Cancer

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The reemergence of salivary gland carcinoma after a period of remission.


name: Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Metastatic Lip Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the lip and has metastasized to another anatomic site.


Advanced Salivary Gland Carcinoma

description: Salivary gland carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Paranasal Sinus Carcinoma

description: Paranasal sinus carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IVA Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage 0 Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Locally Advanced Head and Neck Squamous Cell Carcinoma

description: A head and neck squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Paranasal Sinus Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the paranasal sinuses and is characterized by prominent production of keratin.


name: Platinum-Resistant Head and Neck Carcinoma

description: Head and neck carcinoma that is resistant to platinum therapy.


name: Salivary Gland Intestinal-Type Adenocarcinoma

description: An invasive adenocarcinoma that arises from the salivary gland. Morphologically, it is characterized by the presence of intestinal-type malignant epithelial cells.


name: Stage III Nasal Cavity Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Tumor restricted to any one subsite, with or without bony invasion.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Metastatic Lip and Oral Cavity Carcinoma

description: A carcinoma that arises from the lip and/or oral cavity and has metastasized to another anatomic site.


name: Recurrent Lip and Oral Cavity Squamous Cell Carcinoma

description: The reemergence of lip and oral cavity squamous cell carcinoma after a period of remission.


Low Grade Salivary Gland Carcinoma

description: A salivary gland carcinoma with low-grade histopathologic features.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, and low grade salivary gland mucoepidermoid carcinoma.  It usually follows a non-aggressive clinical course.


name: Stage IVB Lip and Oral Cavity Cancer AJCC v8

description: Stage IVB includes: (Any T, N3, M0); (T4b, Any N, M0). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. (AJCC 8th Ed.)


name: Head and Neck Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the head and neck region and is characterized by prominent production of keratin.


Unresectable Salivary Gland Carcinoma

description: Salivary gland carcinoma that is not amenable to surgical resection.


name: Stage IVC Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7


name: Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


Metastatic Sinonasal Carcinoma

description: Sinonasal carcinoma that has spread from its original site of growth to another anatomic site.


name: Low Grade Salivary Gland Mucoepidermoid Carcinoma

description: A salivary gland mucoepidermoid carcinoma with low-grade histopathologic features. It usually follows a non-aggressive clinical course.


Recurrent Lip Basal Cell Carcinoma

description: Reemergence of basal cell carcinoma of the lip after a period of remission.


name: Salivary Gland Polymorphous Adenocarcinoma, Cribriform Subtype

description: A salivary gland polymorphous adenocarcinoma characterized by the presence of malignant cells forming cribriform and multinodular patterns.


name: Locally Advanced Lip and Oral Cavity Carcinoma

description: Lip and oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Metastatic Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Stage II Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage II Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th ed.)


name: Minor Salivary Gland Acinic Cell Carcinoma

description: An adenocarcinoma with serous acinar cell differentiation that arises from the minor salivary glands.


name: Stage II Nasal Cavity Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Head and Neck Heterotopia-Associated Carcinoma

description: A head and neck carcinoma arising from heterotopic tissue elements (i.e. histologically normal tissue of a particular type that is present at an abnormal anatomical site). (WHO 2017)


name: Stage II Oral Cavity Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Recurrent Salivary Gland Mucoepidermoid Carcinoma

description: The reemergence of salivary gland mucoepidermoid carcinoma after a period of remission.


name: Stage 0 Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Ameloblastic Carcinoma-Secondary Type (Dedifferentiated), Intraosseous

description: A very rare ameloblastic carcinoma that originates from a pre-existing intraosseous benign ameloblastoma.


name: Paranasal Sinus Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the paranasal sinuses.


name: SWI/SNF Complex-Deficient Sinonasal Carcinoma

description: A highly aggressive, poorly to undifferentiated carcinoma that arises from the sinonasal tract. It is characterized by loss of one SWI/SNF complex subunit (either SMARCB1 or SMARCA4) and lacks histological features to allow classification into another specific entity. Most patients present with locally advanced disease.


Head and neck cancer metastatic

description: A carcinoma that arises from the head and neck and has spread from the original site of growth to another anatomic site.


name: Locally Advanced Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Sinonasal Carcinoma

description: Sinonasal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: The reemergence of cutaneous squamous cell carcinoma of the head and neck after a period of remission.


name: Stage I Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Adenocarcinoma

description: Adenocarcinomas that arises from the sinonasal tract. This category includes salivary-type and non-salivary type adenocarcinomas. The latter includes intestinal-type and non-intestinal-type adenocarcinomas.


name: Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Posterior Tongue Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma arising from the minor salivary glands in the base of the tongue.


name: Metastatic Salivary Gland Secretory Carcinoma

description: A salivary gland secretory carcinoma that has spread from its original site of growth to other anatomic sites.


name: Stage IVC Oral Cavity Cancer AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


adenocarcinoma of oral cavity

description: An adenocarcinoma that arises from the oral cavity.


Sinonasal Adenocarcinoma, Salivary-Type

description: Adenocarcinomas that arise from the seromucinous glands and surface epithelium of the nasal cavity and paranasal sinuses. These adenocarcinomas morphologically resemble the adenocarcinomas that arise from the major and minor salivary glands.


name: Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease.  Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Hard Palate Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma arising from the minor salivary glands in the hard palate.


name: Stage II Lip and Oral Cavity Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


name: Locally Advanced Salivary Gland Carcinoma

description: A salivary gland carcinoma that has spread to nearby tissues or lymph nodes.


name: Tracheal Basaloid Squamous Cell Carcinoma

description: A high-grade, aggressive variant of squamous cell carcinoma that arises from the trachea. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.


Adult Salivary Gland Carcinoma

description: A carcinoma of the salivary gland that occurs during adulthood.


name: Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v6

description: Stage IV maxillary sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following areas: the maxillary sinus, bones around the maxillary sinus, tissues under the skin, the eye socket, the base of the skull, and the ethmoid sinuses or cancer is found in one or more lymph nodes in the neck, none larger than 6 centimeters, and in any of the following areas: the front of the eye, the skin of the cheek, the base of the skull, behind the jaw, the bone between the eyes, and the sphenoid or frontal sinuses. Stage IVB: cancer has spread to either: one or more lymph nodes larger than 6 centimeters; or the back of the eye, the brain, the base and middle parts of the skull, nerves in the head, and/or the upper part of the throat behind the nose; cancer may also be found in one or more lymph nodes. Stage IVC: cancer has spread to other parts of the body.  Stage IV nasal cavity and ethmoid sinus cancer: Stage IV is divided into stages IVA, IVB, and IVC.  Stage IVA: cancer has spread to either one lymph node on the same side of the neck as the cancer and the lymph node is larger than 3 centimeters but smaller than 6 centimeters; or, cancer has spread to more than one lymph node anywhere in the neck, and all are 6 centimeters or smaller; cancer is also found in any of the following places: the nasal cavity or ethmoid sinus., the eye socket, the maxillary sinus, the roof of the mouth, and the bone between the eyes or cancer is found in one or more lymph nodes in the neck, and the lymph nodes are 6 centimeters or smaller; cancer is also found in any of the following areas: the front of the eye, the skin of the nose or cheek, front parts of the skull, the base of the skull, and the sphenoid or frontal sinuses.  Stage IVB: cancer is found in any of the following areas: the back of the eye, the brain, the middle parts of the skull, nerves in the head the upper part of the throat behind the nose and the base of the skull.  Cancer may also be found in one or more lymph nodes or cancer is found in a lymph node that is larger than 6 centimeters.  Stage IVC: cancer has spread to other parts of the body (from PDQ).


name: Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease. Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage III Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Unresectable Sinonasal Squamous Cell Carcinoma

description: Sinonasal squamous cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of salivary gland

description: A salivary gland carcinoma characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


Sinonasal Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the nasal cavity and paranasal sinuses.


name: Unresectable Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that is not amenable to surgical resection.


name: Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that has spread from the original site of growth to another anatomic site.


Stage I Paranasal Sinus Cancer

description: Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Cancer by AJCC v6 Stage

description: A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 6th edition.


Tongue Carcinoma

description: A malignant tumor arising from the epithelium that covers the tongue.  The vast majority of tongue carcinomas are moderately or poorly differentiated squamous cell carcinomas.


name: Metastatic Oral Cavity Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


Carcinoma in situ of middle ear

description: An intraepithelial squamous cell carcinoma that arises from the external auditory canal without evidence of invasion.


name: Salivary Gland Poorly Differentiated Carcinoma

description: A high-grade carcinoma that arises from the salivary glands. This category includes large and small cell types with or without neuroendocrine differentiation.


name: Low Grade Papillary Schneiderian Carcinoma

description: A rare sinonasal carcinoma characterized by the presence of a papillary architecture and bland morphological features similar to the Schneiderian papilloma, a pushing pattern of stromal invasion, and an increased risk of local recurrence.


name: Adenoid cystic carcinoma of the oral cavity recurrent

description: The reemergence of adenoid cystic carcinoma in the oral cavity after a period of remission.


name: Stage IV Oral Cavity Cancer AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Recurrent Oral Cavity Carcinoma

description: The reemergence of carcinoma in the oral cavity after a period of remission.


name: Recurrent Paranasal Sinus Squamous Cell Carcinoma

description: The reemergence of paranasal sinus squamous cell carcinoma after a period of remission.


SMARCA4 -Deficient Sinonasal Carcinoma

description: An SWI/SNF-deficient sinonasal carcinoma characterized by inactivating mutation of SMARCA4 gene. It usually affects the nasal sinuses. It is composed of malignant large epithelioid anaplastic cells.


name: adenoid cystic carcinoma of floor of mouth

description: An adenoid cystic carcinoma of the oral cavity that arises from the floor of the mouth.


name: Stage I Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face).  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Localized Head and Neck Carcinoma

description: Head and neck carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


name: Sinonasal Adenocarcinoma, Intestinal-Type with Mixed Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a mixture of growth patterns.


name: Mucoepidermoid carcinoma of the oral cavity recurrent

description: The reemergence of mucoepidermoid carcinoma in the oral cavity after a period of remission.


name: Squamous cell carcinoma of the oral cavity stage IV


name: Intermediate Grade Salivary Gland Mucoepidermoid Carcinoma

description: A salivary gland mucoepidermoid carcinoma with intermediate-grade histopathologic features.


name: Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: A squamous cell carcinoma that arises from the skin of the head and neck.


Stage I Lip Carcinoma

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Oncocytic Carcinoma

description: A high grade adenocarcinoma that arises from the salivary glands. The vast majority of cases have been described in the parotid gland.  It is characterized by the presence of malignant oncocytes.  It recurs and metastasizes to regional or distant anatomic sites.


name: Stage IVA Paranasal Sinus Cancer AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses.  Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


Adenoid cystic carcinoma of the tongue

description: An adenoid cystic carcinoma arising from the minor salivary glands in the tongue.


name: Metastatic Salivary Gland Adenocarcinoma

description: Salivary gland adenocarcinoma that has spread from its original site of growth to another anatomic site.


Refractory Head and Neck Carcinoma

description: A head and neck carcinoma that does not respond to treatment.


Recurrent Head and Neck Carcinoma

description: The reemergence of carcinoma in the head and neck region after a period of remission.


name: Minor Salivary Gland Sclerosing Microcystic Adenocarcinoma

description: A low-grade adenocarcinoma that arises from the minor salivary glands, usually in the oral cavity. It is characterized by the presence of a biphasic population of ductal and myoepithelial cells in a collagenous stroma. The prognosis is good.


Recurrent Sinonasal Carcinoma

description: The reemergence of nasal cavity or paranasal sinus carcinoma after a period of remission.


Head and Neck NUT Carcinoma

description: A highly aggressive, poorly differentiated carcinoma that arises from the head and neck. Most cases are in the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene.


name: Minor Salivary Gland Squamous Cell Carcinoma

description: A squamous cell carcinoma that affects the minor salivary glands.


name: Stage IVA Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip and oral cavity cancer with moderately advanced local disease.  Lip: Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  Oral cavity: Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: High Grade Salivary Gland Mucoepidermoid Carcinoma

description: A salivary gland mucoepidermoid carcinoma with high-grade histopathologic features. It usually follows an aggressive clinical course.


name: Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


Adenocarcinoma of salivary gland

description: An adenocarcinoma arising from the salivary gland.  It includes the salivary gland polymorphous low grade adenocarcinoma, salivary gland oncocytic carcinoma, salivary gland mucinous adenocarcinoma, salivary gland low grade cribriform cystadenocarcinoma, salivary gland cystadenocarcinoma, salivary gland basal cell adenocarcinoma, salivary gland acinic cell carcinoma, salivary duct carcinoma, and salivary gland adenocarcinoma not otherwise specified.


name: Recurrent Minor Salivary Gland Adenocarcinoma

description: The reemergence of minor salivary gland adenocarcinoma after a period of remission.


Stage IV Nasal Cavity Cancer

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Stage IVB Paranasal Sinus Cancer AJCC v7


name: Stage II Paranasal Sinus Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Squamous cell carcinoma of the oral cavity stage II

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage III Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Sinonasal Small Cell Neuroendocrine Carcinoma

description: A very rare small cell neuroendocrine carcinoma that arises from the nose and paranasal sinuses.


name: Squamous cell carcinoma of the oral cavity stage III


name: ASPH-Positive Head and Neck Squamous Cell Carcinoma

description: A head and neck squamous cell carcinoma in which the malignant cells are positive for ASPH gene.


name: Salivary Gland Hyalinizing Clear Cell Carcinoma

description: A rare, slow-growing carcinoma that arises from the salivary glands, usually the minor salivary glands of the oral cavity. It is composed of malignant clear and eosinophilic cells in a hyalinized stroma. Most cases are associated with translocation of EWSR1 and ATF1, resulting in the formation of EWSR1-ATF1 fusion gene. The prognosis is good.


name: Salivary Gland High Grade Adenocarcinoma, Not Otherwise Specified

description: A salivary gland adenocarcinoma, not otherwise specified, characterized by the presence of high-grade morphological features.


name: Sinonasal Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the mucosal epithelium of the nasal cavity or the paranasal sinuses and is characterized by prominent production of keratin.


name: Stage IVC Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Sinonasal Lymphoepithelial Carcinoma

description: A nonkeratinizing squamous cell carcinoma arising from the sinonasal tract. It is characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate.


name: Stage I Oral Cavity Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (Any T, N3, M0); (T4, Any N, M0); (Any T, Any N, M1). T1: Tumor smaller than 2 cm in greatest dimension. T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. T3: Tumor 4 cm or larger in greatest dimension or minor bone erosion or perineural invasion or deep invasion. Deep invasion is defined as invasion beyond the subcutaneous fat or larger than 6 mm; perineural invasion for T3 classification is defined as tumor cells within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm or larger in caliber, or presenting with clinical or radiographic involvement of named nerves without skull base invasion or transgression. T4: Tumor with gross cortical bone/marrow, skull base invasion and/or skull base foramen invasion. N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).  N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes, any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Sellar Choriocarcinoma

description: A choriocarcinoma that arises from or adjacent to the sellar region.


name: Stage II Lip and Oral Cavity Cancer AJCC v6 and v7


name: Salivary Gland Microsecretory Adenocarcinoma

description: A rare, low-grade adenocarcinoma that arises from the salivary gland. Almost all cases have been described in the oral cavity. It is characterized by a microcystic growth pattern, uniform intercalated duct-like tumor cells, basophilic luminal secretions, and fibromyxoid stroma formation. It is associated with MEF2C-SS18 fusion gene expression.


Recurrent Salivary Gland Adenocarcinoma

description: The reemergence of salivary gland adenocarcinoma after a period of remission.


Locally Advanced Oral Cavity Carcinoma

description: Oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage IVA Lip Cancer AJCC v6 and v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Lip cancer with moderately advanced local disease.  Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Minor Salivary Gland Mucoepidermoid Carcinoma

description: A carcinoma that arises from the minor salivary glands.  It usually presents as a firm and painless mass.  It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type.  The majority of cases have a favorable outcome.


description: An SWI/SNF-deficient sinonasal carcinoma characterized by inactivating mutation of SMARCB1 gene. It usually affects the nasal sinuses. It is composed of malignant epithelial cells with a predominantly oncocytoid/plasmacytoid morphology and prominent glandular formations.


name: Stage IV Lip and Oral Cavity Cancer AJCC v8

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar nerve, floor of mouth, or skin of face (i.e., chin or nose).  T4a (oral cavity): Tumor invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla, or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth socket (alone) by a gingival primary is not sufficient to classify a tumor as T4. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases the internal carotid artery. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral lymph nodes any with ENE(+). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th Ed.)


Anterior Tongue Carcinoma

description: A carcinoma that arises from the anterior two-thirds of the tongue.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


name: Salivary Gland Poorly Differentiated Squamous Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma arising from the salivary gland.


name: Locally Advanced Sinonasal Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the nasal cavity and/or paranasal sinuses and has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage III Paranasal Sinus Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Adenoid cystic carcinoma of the oral cavity stage IV


Salivary Gland Clear Cell Carcinoma

description: A carcinoma that arises from the salivary glands, most often the minor salivary glands.  It is characterized by the presence of a monomorphic population of malignant epithelial cells with clear cytoplasm and the absence of morphologic features that define other primary neoplasms of the salivary glands.


name: Locally Recurrent Oral Cavity Squamous Cell Carcinoma

description: The reemergence of oral cavity squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Unresectable Salivary Gland Squamous Cell Carcinoma

description: Salivary gland squamous cell carcinoma that is not amenable to surgical resection.


name: Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th ed.)


Anterior Tongue Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the anterior two-thirds of the tongue.  It usually presents as a painful ulcerated or nodular lesion.


name: Sinonasal Adenocarcinoma, Intestinal-Type with Colonic Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a tubuloglandular growth pattern.


name: Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1). T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses. Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses. T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve (V2), nasopharynx, or clivus. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes , none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+). M0: No distant metastasis. M1: Distant metastasis.  (AJCC 8th ed.)


name: Stage IVC Lip and Oral Cavity Cancer AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Ameloblastic Carcinoma-Secondary Type (Dedifferentiated)

description: A very rare ameloblastic carcinoma that originates from a pre-existing benign ameloblastoma.


name: Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0). T4b: Very advanced local disease. Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve (V2), nasopharynx, or clivus. N3: Metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral or bilateral nodes, any with ENE(+). M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Lip Carcinoma

description: A carcinoma that arises from the lip and has metastasized to another anatomic site.


name: Adenoid cystic carcinoma of the oral cavity stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Minor Salivary Gland Undifferentiated Carcinoma

description: A carcinoma that affects the minor salivary glands and is characterized by the presence of undifferentiated, anaplastic malignant epithelial cells.


name: lymphoepithelial squamous cell carcinoma of salivary gland

description: A rare carcinoma that arises from the salivary glands, most often the parotid gland.  It is characterized by the presence of an undifferentiated carcinomatous component associated with a prominent reactive lymphoplasmacytic infiltrate.


cystadenocarcinoma of salivary gland

description: A rare, low-grade adenocarcinoma that arises from the salivary glands.  It presents as a slow growing asymptomatic mass and is characterized by the presence of multiple cystic spaces.


name: Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma

description: A squamous cell carcinoma associated with human papilloma virus, arising from the mucosal sites of head and neck.


name: Salivary Gland Adenocarcinoma, Not Otherwise Specified

description: An adenocarcinoma that arises from the salivary glands.  It exhibits ductal differentiation but lacks any of the morphologic features that characterize the other well-defined primary adenocarcinomas of the salivary glands.


name: Metastatic Sinonasal Squamous Cell Carcinoma

description: Nasal cavity and/or paranasal sinus squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Mucoepidermoid carcinoma of the oral cavity stage II

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Sinonasal Adenocarcinoma, Intestinal-Type with Solid Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a solid growth pattern.


Alveolar Ridge Squamous Cell Carcinoma

description: Squamous cell carcinoma arising from the upper or lower alveolar ridge.


name: Unresectable Head and Neck Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the head and neck region and is not amenable to surgical resection.


High Grade Salivary Gland Carcinoma

description: A usually aggressive salivary gland carcinoma with high-grade histopathologic features.  It includes the salivary duct carcinoma, salivary gland oncocytic carcinoma, and high grade salivary gland mucoepidermoid carcinoma.


name: Salivary Gland Polymorphous Adenocarcinoma, Conventional Subtype

description: A salivary gland polymorphous adenocarcinoma characterized by the presence of uniform malignant cells with scant cytoplasm forming trabecular, tubular, microcystic, solid, and papillary-cystic patterns. The tumor stroma can be mucinous, myxoid, or hyalinized. Perineural involvement is often seen.


name: Ameloblastic Carcinoma-Secondary Type (Dedifferentiated), Peripheral

description: A very rare ameloblastic carcinoma that originates from a pre-existing extraosseous benign ameloblastoma.


name: Recurrent Salivary Gland Adenocarcinoma, Not Otherwise Specified

description: The reemergence of salivary gland adenocarcinoma, not otherwise specified after a period of remission.


name: Stage IVC Lip and Oral Cavity Cancer AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th Ed.)


Stage IV Lip Cancer AJCC v6 and v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose.  T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension.  N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis. (AJCC 6th and 7th eds.)


name: Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


Head and Neck Basaloid Carcinoma

description: A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region.  The most common sites of origin are pyriform sinus, epiglottis, and base of tongue.  It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.  Comedonecrosis may be present.


name: Metastatic Oral Cavity Adenoid Cystic Carcinoma

description: An adenoid cystic carcinoma that arises from the oral cavity and has metastasized to another anatomic site.


name: Stage 0 Paranasal Sinus Cancer AJCC v6, v7, and v8

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


name: Metastatic Salivary Gland Adenocarcinoma, Not Otherwise Specified

description: Salivary gland adenocarcinoma, not otherwise specified that has spread from its original site of growth to another anatomic site.


Salivary Gland Myoepithelial Carcinoma

description: A locally aggressive carcinoma that arises from the salivary glands, predominantly the parotid gland. It is characterized by the presence of a malignant cellular infiltrate exhibiting myoepithelial differentiation. Patients usually present with a painless mass.


name: Stage 0 Sinonasal Cancer AJCC v6, v7, and v8


name: Posterior Tongue Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma arising from the minor salivary glands in the base of the tongue.


name: Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


Mucoepidermoid carcinoma of the tongue

description: A mucoepidermoid carcinoma that arises from the tongue.


Odontogenic Carcinoma

description: A carcinoma that arises from tooth-forming tissues.


Palate carcinoma

description: A carcinoma that arises from the hard or soft palate.  Representative examples include squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.


name: Squamous cell carcinoma of the oral cavity recurrent

description: Reemergence of squamous cell carcinoma of the oral cavity after a period of remission.


name: Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Sinonasal Cancer by AJCC v7 Stage

description: A term that refers to the staging of nasal cavity and paranasal sinus carcinoma according to the American Joint Committee on Cancer, 7th edition.


Stage III Lip Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Salivary Gland Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the salivary glands. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


name: Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.  Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion.  T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage III Lip and Oral Cavity Cancer AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI. T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (extranodal extension)(-). M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Salivary Gland Squamous Cell Carcinoma

description: The reemergence of salivary gland squamous cell carcinoma after a period of remission.


name: Cribriform Adenocarcinoma of Minor Salivary Gland

description: A minor salivary gland adenocarcinoma characterized by a cribriform pattern. It often metastasizes to the neck lymph nodes.


Refractory Salivary Gland Carcinoma

description: Salivary gland carcinoma that is resistant to treatment.


Salivary Gland Intraductal Carcinoma

description: A rare, low-grade adenocarcinoma that arises from the salivary glands.  It is characterized by the presence of cystic structures lined by ductal cells which are arranged in cribriform patterns.  Adjacent ducts show intraductal proliferation.


name: Stage IVC Paranasal Sinus Cancer AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Stage I Nasal Cavity and Paranasal Sinus Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone.  Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Locally Advanced Head and Neck Carcinoma

description: A head and neck carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Head and Neck Squamous Cell Carcinoma

description: The reemergence of squamous cell carcinoma in the head and neck region after a period of remission.


name: basaloid squamous cell carcinoma of floor of mouth

description: An aggressive variant of squamous cell carcinoma that arises from the floor of the mouth. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.


name: Primary Intraosseous Squamous Cell Carcinoma Derived From Odontogenic Cyst

description: A rare primary intraosseous carcinoma, not otherwise specified, that arises from the lining of an odontogenic cyst.


name: large cell neuroendocrine carcinoma of salivary gland

description: A large cell carcinoma that arises from the salivary glands and exhibits neuroendocrine differentiation.


name: Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses.  Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses.  T4b: Very advanced local disease.  Tumor invades any of the following: orbital apex, dura, brain, middle cranial fossa, cranial nerves other than maxillary division of trigeminal nerve, nasopharynx, or clivus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 7th ed.)


Head and Neck Neuroendocrine Carcinoma

description: A rare neuroendocrine carcinoma that arises from the head and neck.


name: Mucoepidermoid carcinoma of the oral cavity stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Clear cell odontogenic carcinoma

description: A usually aggressive malignant neoplasm arising from tooth-forming tissues. It more often affects older females and more frequently occurs in the mandible. It is characterized by the presence of malignant epithelial cells with clear cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection with clean margins.


name: Sinonasal Adenocarcinoma, Intestinal-Type with Mucinous Pattern

description: An intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of malignant glandular cells with intracytoplasmic mucin.


Primary ameloblastic carcinoma

description: A rare, aggressive odontogenic malignant tumor that arises usually from the mandible and less frequently from the maxilla.  It combines the histologic features of an ameloblastoma and carcinoma.


name: Mucoepidermoid carcinoma of the oral cavity stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Lip and Oral Cavity Cancer by AJCC v8 Stage

description: A term that refers to the staging of lip and oral cavity carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage III Oral Cavity Cancer AJCC v6 and v7


name: Adenoid cystic carcinoma of the oral cavity

description: An adenoid cystic carcinoma arising from the minor salivary glands in the oral cavity.


name: Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor smaller than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Salivary Gland Intermediate Grade Adenocarcinoma, Not Otherwise Specified

description: A salivary gland adenocarcinoma, not otherwise specified, characterized by the presence of intermediate-grade morphological features.


name: Polymorphous low grade adenocarcinoma of salivary gland

description: A low grade malignant epithelial neoplasm arising from the salivary gland. It usually arises from the oral cavity, with approximately 60% of the cases involving the palate. The most common presenting sign is a painless mass in the palate. It is characterized by the presence of uniform, small to medium size malignant epithelial cells and an infiltrating pattern. There is a variety of morphologic patterns which may be present within an individual tumor, including lobular, papillary, papillary-cystic, cribriform, and trabecular pattern. It usually has a favorable clinical outcome and a low metastatic potential.


name: Anterior Tongue Mucoepidermoid Carcinoma

description: A mucoepidermoid carcinoma arising from the minor salivary glands in the anterior tongue.


Ear carcinoma

description: A carcinoma that arises from the ear.  Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear.


name: Head and Neck Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that arises from the head and neck.


name: Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v8

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Maxillary sinus: Moderately advanced local disease. Tumor invades anterior orbital contents, skin of cheek, pterygoid plates, infratemporal fossa, cribriform plate, sphenoid or frontal sinuses. Nasal cavity and ethmoid sinus: Moderately advanced local disease. Tumor invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid or frontal sinuses. T1: Maxillary sinus: Tumor limited to the maxillary sinus mucosa with no erosion or destruction of bone. Nasal cavity and ethmoid sinus: Tumor restricted to any one subsite, with or without bony invasion. T2: Maxillary sinus: Tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates. Nasal cavity and ethmoid sinus: Tumor invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, with or without bony invasion. T3: Maxillary sinus: Tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses. Nasal cavity and ethmoid sinus: Tumor invading the medial wall or floor of the orbit, maxillary sinus, palate, or cribriform plate. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes , none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th ed.)


iminium ion

Cations of structure R2C=N(+)R2.


Grade 4 Esophageal Fistula, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Life-threatening consequences; urgent intervention indicated


Esophageal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site.


Grade 2 Esophageal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Grade 3 Esophageal Fistula, CTCAE

description: Invasive intervention indicated


Grade 5 Esophageal Fistula, CTCAE

description: Death


Grade 1 Esophageal Fistula, CTCAE

description: Asymptomatic


name: Cutaneous Indeterminate Dendritic Cell Histiocytosis

description: A very rare dendritic cell tumor affecting the skin. It is composed of spindle to ovoid cells with a phenotype that is similar to the Langerhans cells. It manifests with cutaneous papules, nodules, and plaques.  The clinical course is variable.


name: Stage III Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2

description: T2 or T3 or T4, N0, M0, G2 or G3 or Any T, N1, M0, Any G (G1, G2, G3 or GX). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Seminal Vesicle Angiosarcoma

description: An extremely rare angiosarcoma that affects the seminal vesicle.


name: Head and Neck Extraskeletal Myxoid Chondrosarcoma

description: An extraskeletal myxoid chondrosarcoma that arises from the head and neck. The orbit is the most frequently affected site.


name: Stage IVA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Benign fibrohistiocytic neoplasm of skin

description: A benign neoplasm arising from the skin. It is composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes arranged in a storiform pattern.


Childhood Tenosynovial Giant Cell Tumor

description: A tenosynovial giant cell tumor that occurs during childhood.


Vulvar Rhabdomyosarcoma

description: A malignant mesenchymal neoplasm with skeletal muscle differentiation arising from the vulva.


name: Central Nervous System Solitary Fibrous Tumor

description: A mesenchymal, non-meningothelial neoplasm arising from the central nervous system. It is characterized by a collagenous and low cellularity spindle cell and/or hemangiopericytomatous histopathological pattern, recurrent intrachromosomal rearrangement on chromosome 12q that results in the fusion of the NAB2 and STAT6 genes, high recurrence rates, and long-term risk of systemic metastasis.


Extraskeletal osteosarcoma recurrent

description: The reemergence of extraskeletal osteosarcoma after a period of remission.


Digestive System Kaposi Sarcoma

description: A Kaposi sarcoma arising from the digestive system.


Dermatomyofibroma

description: A rare benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation. (WHO 2018)


Giant Cell Angiofibroma

description: A morphologic variant of angiofibroma characterized by the presence of multinucleated giant cells, collagenous or myxoid stroma, focal sclerotic areas, and angiectoid spaces.


Parotid Gland Nodular Fasciitis

description: A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the parotid gland. It is composed of fibroblastic/myofibroblastic cells.


Esophageal Rhabdomyosarcoma

description: A rhabdomyosarcoma arising from the esophageal wall.


name: Head and Neck Inflammatory Myofibroblastic Tumor

description: An inflammatory myofibroblastic tumor that arises from the head and neck. The most frequently affected sites are the larynx, sinonasal tract, and oral cavity.


name: Resectable Undifferentiated Pleomorphic Sarcoma

description: Undifferentiated pleomorphic sarcoma that is amenable to surgical resection.


name: Childhood Rhabdomyosarcoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood rhabdomyosarcoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


name: Localized Childhood Non-Rhabdomyosarcoma Soft Tissue Sarcoma by Toronto Guidelines v2

description: Tumor confined to the area of origin including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Prostate Osteosarcoma

description: A rare osteosarcoma that arises from the prostate gland.


Oral Cavity Leiomyoma

description: A benign smooth muscle neoplasm arising from the oral cavity. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.


Central Nervous System Myofibroblastoma

description: A rare myofibroblastoma affecting the central nervous system.


name: Gastrointestinal Stromal Tumor of the Gastrointestinal Tract

description: A stromal tumor that originates from the interstitial cells of Cajal. It may involve any part of the gastrointestinal tract. The majority of cases occur in the stomach. Morphologic variants include the epithelioid cell type, spindle cell type, and mixed cell type. Most cases contain KIT- or PDGFRA-activating mutations. Lesions with a diameter greater than 10cm and more than 5 mitotic figures per 50HPF tend to have a more aggressive clinical course. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases.


Esophageal Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the esophagus.


Recurrent Adult Soft Tissue Sarcoma

description: A soft tissue sarcoma occurring in adults that has recurred after a period of remission.


Salivary Gland Nodular Fasciitis

description: A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the salivary glands. It is composed of fibroblastic/myofibroblastic cells. It usually occurs in the parotid gland.


name: Stage II Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

description: Stage II includes: T3, N0, M0, Low Mitotic Rate. T3: Tumor measuring more than 5 cm but not more than 10 cm. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


name: Uterine Corpus Inflammatory Myofibroblastic Tumor

description: A rare inflammatory myofibroblastic tumor that arises from the uterine corpus.


Cellular angiofibroma

description: A benign mesenchymal neoplasm that usually arises in the superficial soft tissues of the vulva or inguinal and scrotal regions.  It is characterized by the presence of a cellular fibroblastic proliferation in an edematous to fibrous stroma containing numerous vessels.


Localized Soft Tissue Sarcoma

description: A soft tissue sarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


name: Prostate Undifferentiated Pleomorphic Sarcoma

description: A rare undifferentiated pleomorphic sarcoma that arises from the prostate gland.


Head and Neck Leiomyoma

description: A benign neoplasm with smooth muscle differentiation that arises from the head and neck. The most frequently affected site is the oral cavity.


Bladder Alveolar Soft Part Sarcoma

description: An alveolar soft part sarcoma involving the bladder.


Advanced Kaposi Sarcoma

description: Kaposi sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


EBV-Related Sarcoma

description: Sarcoma that is caused by Epstein-Barr virus infection.


name: Benign Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm

description: A mesenchymal, non-meningothelial neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Kidney Oncocytoma-Like Angiomyolipoma

description: A rare angiomyolipoma of the kidney characterized by the presence of polygonal cells with eosinophilic cytoplasm.


Seminal Vesicle Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the seminal vesicle.


Stage II Uterine Sarcoma AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor extends beyond the uterus, within the pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  This staging applies to leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. (AJCC 7th ed.)


name: Stage II Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8

description: Stage II includes: (T1, N0, M0, High Mitotic Rate); (T2, N0, M0, High Mitotic Rate); (T4, N0, M0, Low Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


name: Stage IIB Adult Soft Tissue Sarcoma AJCC v7


name: Plaque-like CD34 positive dermal fibroma

description: A congenital or acquired benign dermal spindle cell neoplasm with histopathological features mimicking those of superficial dermal dermatofibrosarcoma protuberans. (WHO 2018)


name: Metastatic Extraskeletal Myxoid Chondrosarcoma

description: An extraskeletal myxoid chondrosarcoma which has spread to another anatomic site.


Bladder PEComa

description: A benign or malignant perivascular epithelioid cell tumor arising from the bladder.


name: Gastrointestinal Clear Cell Sarcoma/Malignant Gastrointestinal Neuroectodermal Tumor

description: A gastrointestinal tract sarcoma with neuroectodermal differentiation. It is characterized by the presence of neoplastic round cells with pale eosinophilic cytoplasm. Cytoplasmic clearing is seen only in a minority of cases. Half of the cases contain osteoclastic giant cells. It is associated with gene fusion translocations involving the EWSR1 gene, usually EWSR1-ATF1 fusion or EWSR1-CREB1 fusion.


Lacrimal Gland Myoepithelioma

description: A benign neoplasm with myoepithelial differentiation arising from the lacrimal gland. It lacks an infiltrative growth pattern and does not metastasize.


Uterine Corpus Smooth Muscle Neoplasm

description: A benign, intermediate, or malignant neoplasm that arises from the uterine corpus and is composed of neoplastic cells with smooth muscle differentiation.


name: Childhood Desmoplastic Small Round Cell Tumor

description: A desmoplastic small round cell tumor occurring in children.


Malignant ossifying fibromyxoid tumor

description: An ossifying fibromyxoid tumor characterized by the presence of high grade nuclear features or increased cellularity and more than two mitotic figures per 50 HPFs.


Salivary Gland Myoepithelial Tumor

description: A benign or malignant tumor that arises from the salivary glands.  It is characterized by the presence of neoplastic cells with myoepithelial differentiation.  This category includes benign myoepithelioma and myoepithelial carcinoma.


Vulvar Angiosarcoma

description: A rare angiosarcoma that arises from the vulva.


Synovial sarcoma metastatic

description: A synovial sarcoma that has metastasized to other anatomic sites.


Childhood Rhabdomyoma

description: A rhabdomyoma that occurs during childhood.


Childhood Synovial Sarcoma

description: A synovial sarcoma occurring in childhood.


Liver Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the liver and intrahepatic bile ducts.


name: Stage IB Gastric Gastrointestinal Stromal Tumor

description: Stage IB includes: T3, N0, M0, Mitotic rate: Low.  T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Vulvar Soft Tissue Neoplasm

description: A benign or malignant mesenchymal neoplasm of the vulva.  Representative examples include leiomyoma, cellular angiofibroma, angiomyxoma, leiomyosarcoma, liposarcoma, and childhood botryoid-type embryonal rhabdomyosarcoma.


Advanced Alveolar Soft Part Sarcoma

description: Alveolar soft part sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Gastric Inflammatory Myofibroblastic Tumor

description: A multinodular intermediate fibroblastic neoplasm arising from the stomach.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.


name: Stage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

description: Stage III includes: IIIA: (T1, N0, M0, High Mitotic Rate); (T4, N0, M0, Low Mitotic Rate); IIIB: (T2, N0, M0, High Mitotic Rate); (T3, N0, M0, High Mitotic Rate); (T4, N0, M0, High Mitotic Rate). T1: Tumor measuring 2 cm or less. T2: Tumor measuring more than 2 cm but not more than 5 cm. T3: Tumor measuring more than 5 cm but not more than 10 cm. T4: Tumor measuring more than 10 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. M0: No distant metastasis. High Mitotic Rate: Over 5 mitoses per 5 square millimeters, or per 50 HPF. Low Mitotic Rate: Five or fewer mitoses per 5 square millimeters, or per 50 HPF. (AJCC 8th ed.)


Sinonasal Desmoid Fibromatosis

description: Desmoid fibromatosis that arises from the nasal cavity and paranasal sinuses.


Gastric Synovial Sarcoma

description: A rare synovial sarcoma that arises from the stomach.


name: Cervical Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant neoplasm with nerve sheath differentiation arising from the cervix.


Breast Nodular Fasciitis

description: A self-limiting, rapidly growing, non-encapsulated benign neoplasm that arises from the breast. It has been described in both the subcutis and parenchyma of the breast. It occurs most frequently in the upper-outer quadrant. It is composed of fibroblastic/myofibroblastic cells.


Pilar-Associated Mesenchyme Neoplasm

description: A mesenchymal neoplasm arising from the pilar sheath of the hair follicle.


name: Gastric Malignant Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor arising from the stomach.  It is characterized by large size (diameter greater than 10 cm) or more than 5 mitotic figures per 50 high power fields.


Benign Sinonasal Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the nasal cavity and paranasal sinuses and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Alveolar soft part sarcoma metastatic

description: An alveolar soft part sarcoma which has spread to another anatomic site.


Stage III Soft Tissue Sarcoma AJCC v7

description: Stage III includes: (T2a, T2b, N0, M0, G3); (Any T, N1, M0, Any G).  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  G3: Grade 3.  There is no T2a for the pathologic group. (AJCC 7th ed.)


Fibrous tissue neoplasm of skin

description: A neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts.


Vulvar Angiomyxoma

description: A deep or superficial angiomyxoma of the vulva.  It may recur following resection.


Stage II Soft Tissue Sarcoma AJCC v7

description: Stage II includes: IIA (T1a, N0, M0, G2, G3); (T1b, N0, M0, G2, G3); IIB (T2a, N0, M0, G2); (T2b, N0, M0, G2).  T1a: Superficial tumor 5 cm or less in greatest dimension.  T1b: Deep tumor 5 cm or less in greatest dimension.  T2a: Superficial tumor more than 5 cm in greatest dimension.  T2b: Deep tumor more than 5 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G2: Grade 2.  G3: Grade 3. (AJCC 7th ed.)


Metastatic Uterine Corpus Sarcoma

description: Uterine corpus sarcoma that has spread from its original site of growth to another anatomic site.


Biphenotypic sinonasal sarcoma

description: A rare, slow-growing, low-grade soft tissue sarcoma arising from the sinonasal tract. It presents with non-specific obstructive nasal symptoms. Morphologically, it is an infiltrative, cellular spindle cell neoplasm. It is associated with rearrangement of the PAX3 gene.


Tongue GLI1-Altered Soft Tissue Tumor

description: A GLI1-altered soft tissue tumor that arises from the tongue.


name: Breast Inflammatory Myofibroblastic Tumor

description: A multinodular intermediate fibroblastic neoplasm arising from the breast.  It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells.


Bladder Benign PEComa

description: A benign perivascular epithelioid cell tumor arising from the bladder.


name: Recurrent Malignant Soft Tissue Neoplasm

description: Reemergence of a malignant soft tissue neoplasm after a period of remission.


name: Sinonasal Undifferentiated Pleomorphic Sarcoma

description: An undifferentiated pleomorphic sarcoma that arises from the nasal cavity and paranasal sinuses.


name: Head and Neck GLI1-Altered Soft Tissue Tumor

description: A GLI1-altered soft tissue tumor that arises from the head and neck. The majority of cases arise from the tongue. Less frequently involved sites include the submandibular gland and soft tissue of neck.


Locally Advanced Soft Tissue Sarcoma

description: Soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Digestive System Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the digestive system.


Digestive System Lipoma

description: A lipoma arising from an anatomic site in the digestive system.


Recurrent Ectomesenchymoma

description: The reemergence of ectomesenchymoma after a period of remission.


Prostate Solitary Fibrous Tumor

description: A rare solitary fibrous tumor that arises from the prostate gland.


name: Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


AIDS-Related Gastric Kaposi Sarcoma

description: A Kaposi sarcoma arising from the stomach in patients who are infected with the human immunodeficiency virus.


Vulvar Kaposi Sarcoma

description: A Kaposi sarcoma arising from the vulva.


Digestive System Leiomyoma

description: A leiomyoma arising from an anatomic site in the digestive system.


Clear-Cell Myomelanocytic Tumors

description: A very rare, usually benign neoplasm with perivascular epithelioid cell differentiation characterized by the presence of clear spindle cells arranged in fascicles and nests that usually affects young girls.  Patients usually present with a painful abdominal mass.


Rhabdomyosarcoma of urinary bladder

description: A malignant mesenchymal neoplasm with skeletal muscle differentiation arising from the bladder.


Vaginal Superficial Myofibroblastoma

description: An uncommon, benign, well circumscribed mesenchymal neoplasm that grows beneath the vaginal epithelium. It is characterized by the presence of cells containing bland ovoid, spindle, or stellate-shaped nuclei in a collagenous stroma.


name: Uterine Corpus Epithelioid Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic epithelioid cells.


Vaginal Undifferentiated Sarcoma

description: A high grade infiltrating sarcoma that arises from the vagina. It is characterized by the presence of malignant small spindle cells with scant cytoplasm.


Prostate Soft Tissue Neoplasm

description: A mesenchymal neoplasm that arises from the prostate gland.