name: Grade 2 Musculoskeletal Deformity, CTCAE

description: Deformity, hypoplasia, or asymmetry able to be remediated by prosthesis (e.g., shoe insert) or covered by clothing


Grade 4 Pelvic Infection, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Life-threatening consequences; urgent intervention indicated


Pelvic Infection, CTCAE

description: A disorder characterized by an infectious process involving the pelvic cavity.


Grade 3 Pelvic Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Pelvic Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 5 Pelvic Infection, CTCAE

description: Death


ESOXYBUTYNIN

A 4-(diethylamino)but-2-yn-1-ol yhat has S configuration. In contrast to the (R)- enantiomer, esoxybutynin exhibits essentially no anticholinergic activity.


name: Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Grade 3 Middle Ear Intra-Operative Injury, CTCAE


Astrocytoma, Not Otherwise Specified

description: A central nervous system tumor with morphological features of astrocytoma in which there is insufficient information on the IDH genes status.


name: Grade 3 Superficial Soft Tissue Fibrosis, CTCAE

description: Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


name: Grade 1 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Ciliary Body Benign Teratoid Medulloepithelioma

description: A rare, unilateral, benign embryonal neoplasm typically presenting as a ciliary body mass during childhood. It arises from primitive medullary epithelium and contains heterologous elements, particularly cartilage, skeletal muscle, and brain tissue.


Recurrent Extragonadal Seminoma

description: The reemergence of extragonadal seminoma after a period of remission.


name: Recurrent Malignant Extragonadal Germ Cell Tumor

description: The reemergence of malignant extragonadal germ cell tumor after a period of remission.


name: Recurrent Malignant Extragonadal Nongerminomatous Germ Cell Tumor

description: The reemergence of a malignant extragonadal nongerminomatous germ cell tumor after a period of remission.


Stage IA Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma that can be diagnosed only by microscopy, with maximum depth of invasion less than 5 mm. (FIGO 2018)


Stage IA2 Cervical Cancer FIGO 2018

description: Cervical carcinoma with measured stromal invasion equal or more than 3 mm and less than 5 mm in depth. (FIGO 2018)


Stage IA1 Cervical Cancer FIGO 2018

description: Cervical carcinoma with measured stromal invasion less than 3 mm in depth. (FIGO 2018)


QUINOXALINE

A naphthyridine in which the nitrogens are at positions 1 and 4.


name: Grade 3 Vagina Stricture or Stenosis, CTCAE


name: Stage I Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor limited to the pancreas and measuring less than 2 cm. N0: No regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


Infiltrating Intramuscular Lipoma

description: An infiltrating lipoma that affects skeletal muscle.  It has a higher rate of local recurrence.


name: Refractory Endometrial Dedifferentiated Carcinoma

description: Endometrial dedifferentiated carcinoma that is resistant to treatment.


Campylobacter jejuni infection

description: An infection that is caused by Campylobacter jejuni.


Small Intestinal Infection

description: An infectious process affecting the small intestine.


Duodenal Infection

description: An infectious process affecting the duodenum.


Stage IVB Rectal Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis.  (AJCC 8th ed.)


name: Cervical Mucinous Adenocarcinoma, Not Otherwise Specified

description: A cervical mucinous adenocarcinoma in which more than 50% of malignant cells contain intracytoplasmic mucin. There is no evidence of gastric, intestinal, or signet ring cell differentiation.


Localized PRETEX IV Hepatoblastoma

description: PRETEX IV hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


glycerolipid

Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.


triradylglycerol

A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)


glyceride

Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


A 1,2-diacyl-sn-glycerol 3-phosphate in which the acyl substituents at positions 1 and 2 are specified as gamma-linolenoyl and oleoyl respectively.


An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.


glycerophospholipid

Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.


triglyceride

Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.


name: Hepatitis Virus-Related Hepatocellular Carcinoma

description: A hepatocellular carcinoma that develops following hepatitis virus exposure and injury of the liver parenchyma.


Stage IIIA Adult Liver Cancer AJCC v7

description: For hepatocellular carcinoma: Stage IIIA includes: T3a, N0, M0. T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


name: Epithelioid hemangioendothelioma of liver

description: A low-grade malignant blood vessel neoplasm that arises from the liver.  It is characterized by the presence of epithelioid endothelial cells.  The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.  Patients may be asymptomatic or present with an abdominal mass, ascites, and jaundice.


name: Stage I Intrahepatic Bile Duct Cancer AJCC v8

description: Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 5 cm without vascular invasion.  T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Unresectable Fibrolamellar Carcinoma

description: A fibrolamellar carcinoma that is not amenable to surgical resection.


name: Hepatoblastoma with Pure Fetal Epithelial Differentiation

description: A hepatoblastoma composed of small cells resembling the fetal hepatocytes, forming thin trabeculae.


name: Recurrent Adult Hepatocellular Carcinoma

description: A hepatocellular carcinoma that occurs during adulthood and has recurred after a period of remission.


name: Locally Advanced Hepatocellular Carcinoma

description: Hepatocellular carcinoma that has spread to nearby tissues or lymph nodes.


Hepatoblastoma recurrent

description: The reemergence of hepatoblastoma after a period of remission.


name: Stage IV Childhood Hepatocellular Carcinoma AJCC v7

description: Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage 0 Hepatocellular Carcinoma

description: Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


BCLC Stage D Hepatocellular Carcinoma

description: End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


Localized PRETEX III Hepatoblastoma

description: PRETEX III hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Adult Liver Carcinoma

description: A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood.


Liver Synovial Sarcoma

description: A synovial sarcoma that affects the liver.


Stage IV Liver Cancer

description: Stage IV carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Metastatic Fibrolamellar Carcinoma

description: A fibrolamellar carcinoma that has spread from the liver to another anatomic site.


name: Stage III Hepatocellular Carcinoma AJCC v7

description: Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVA Hepatocellular Carcinoma AJCC v7

description: Stage IVA includes: Any T, N1, M0.  N1: Regional lymph node metastasis. M0: No distant metastasis.  (AJCC 7th ed.)


PRETEXT IV Hepatoblastoma

description: An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves all 4 quadrants; there is no quadrant free of tumor. (from PDQ 2004)


Non-Resectable Malignant Liver Neoplasm

description: A malignant liver neoplasm that is not amenable to surgical resection.


name: Adult Pleomorphic Hepatocellular Carcinoma

description: A pleomorphic hepatocellular carcinoma that occurs during adulthood.


name: Childhood Hepatoblastoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood hepatoblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2. It includes localized tumors, metastatic tumors, and the PRETEXT system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IV Hepatocellular Carcinoma AJCC v7


name: BCLC Stage C Adult Hepatocellular Carcinoma

description: Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


name: Stage IV Hepatocellular Carcinoma AJCC v6

description: Stage IV includes (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.)


Extrarenal Rhabdoid Tumor of the Liver

description: A rare, aggressive primary malignant tumor of the liver that occurs in childhood.  It is characterized by the presence of a diffuse infiltrate of undifferentiated cells with rhabdoid features.


Adult Liver Embryonal Sarcoma

description: An embryonal sarcoma of the liver that occurs during adulthood.


Stage II Liver Cancer

description: Stage II carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


Postsurgical Stage III Hepatoblastoma

description: No distant metastases, tumor unresectable or resected with gross residual tumor, or positive lymph nodes. (from PDQ 2004)


PRETEXT III Hepatoblastoma

description: An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 3 adjoining quadrants or 2 nonadjoining quadrants; 1 quadrant or 2 nonadjoining quadrants are free of tumor. (from PDQ 2004)


Refractory Hepatoblastoma

description: Hepatoblastoma that does not respond to treatment.


Uveal Melanoma Metastatic in the Liver

description: A melanoma that originates from melanocytes of the uveal tract and has spread to the liver.


name: Stage II Hepatocellular Carcinoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Solitary tumor larger than 2 cm with vascular invasion, or multiple tumors, none larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Liver Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant small cells.


name: Stage IV Intrahepatic Bile Duct Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage IIIA Hepatocellular Carcinoma AJCC v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Multiple tumors more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Liver Cancer

description: Stage III carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


name: Epithelial Hepatoblastoma with Pleomorphic Pattern

description: Epithelial hepatoblastoma characterized by the presence of fetal or embryonal cells showing nuclear pleomorphism. Malignant giant cells may be present.


Stage IIIC Adult Liver Cancer AJCC v7

description: For hepatocellular carcinoma: Stage IIIC includes: T4, N0, M0.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage I Hepatocellular Carcinoma AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: Solitary tumor without vascular invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Colon Carcinoma Metastatic in the Liver

description: A carcinoma that originates from the colonic wall and has spread to the liver.


name: Stage III Hepatocellular Carcinoma AJCC v8

description: Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0). T3: Multiple tumors, at least one of which is larger than 5 cm. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Non-Teratoid Hepatoblastoma

description: A mixed epithelial and mesenchymal hepatoblastoma characterized by the absence of heterologous elements, muscle, cartilage or osteoid.


name: Stage IIIA Intrahepatic Bile Duct Cancer AJCC v8

description: Stage IIIA includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Liver Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the liver and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Moderately Differentiated Hepatocellular Carcinoma

description: A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns.  It is usually associated with tumors that are larger than 3 cm in diameter.


name: Hepatocellular carcinoma, spindle cell variant

description: A morphologic variant of hepatocellular carcinoma characterized by the presence of malignant spindle cells or atypical giant cells.


carcinosarcoma of liver

description: An aggressive carcinoma with a sarcomatous component that arises from the liver.  The sarcomatous component is clonally related to the more differentiated, carcinomatous component.  The prognosis is usually poor.


Hepatic cancer stage IVA

description: Stage IVA carcinoma of the liver according to the American Joint Committee on Cancer, 7th and 8th editions.


name: Stage II Intrahepatic Bile Duct Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Solitary tumor with intrahepatic vascular invasion, or multiple tumors, with or without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Hepatocellular Malignant Neoplasm, Not Otherwise Specified

description: A rare childhood malignant liver neoplasm with overlapping features of hepatoblastoma and hepatocellular carcinoma.


name: Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7


Locally Advanced Liver Carcinoma

description: Liver carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Teratoid Hepatoblastoma

description: A mixed epithelial and mesenchymal hepatoblastoma characterized by the presence of heterologous elements. The latter include neuroectoderm, endoderm, or melanin-holding cells. Muscle, cartilage and osteoid may or may not be present.


BCLC Stage B Hepatocellular Carcinoma

description: Intermediate hepatocellular carcinoma.  Patients may benefit from chemoembolization. (HPB (Oxford) 2005; 7(1):35-41)


Kaposi's sarcoma of liver

description: A Kaposi sarcoma that arises from the liver.


name: Stage IA Intrahepatic Bile Duct Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Solitary tumor equal to or less than 5 cm without vascular invasion.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


description: Hepatocellular carcinoma characterized by the presence of diffuse neutrophil infiltrates within the tumor.


Stage IIIB Adult Liver Cancer AJCC v7

description: For hepatocellular carcinoma: Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood Hepatoblastoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood hepatoblastoma according to the Toronto childhood cancer staging guidelines v2.


name: Stage 0 Intrahepatic Bile Duct Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (intraductal tumor). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic hepatocellular carcinoma

description: A hepatocellular carcinoma that has spread to another anatomic site.


name: Unresectable Liver and Intrahepatic Bile Duct Carcinoma

description: Liver carcinoma that is not amenable to surgical resection.


Childhood Liver Embryonal Sarcoma

description: An embryonal sarcoma of the liver that occurs during childhood.


name: Recurrent Childhood Hepatocellular Carcinoma

description: A hepatocellular carcinoma that occurs during childhood and has recurred after a period of remission.


Malignant Liver Non-Epithelial Neoplasm

description: A primary or metastatic malignant non-epithelial neoplasm that affects the liver.


name: BCLC Stage B Adult Hepatocellular Carcinoma


name: Hepatocellular Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to hepatocellular carcinomas and fibrolamellar carcinomas (fibrolamellar variant of hepatocellular carcinoma). Intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas, and sarcomas of the liver are not staged using this staging system. (from AJCC 8th Ed.)


description: A hepatocellular carcinoma that arises in a patient with a history of organ transplantation.


name: Hepatitis B Virus-Related Hepatocellular Carcinoma

description: A hepatocellular carcinoma that develops following hepatitis B virus exposure and injury of the liver parenchyma.


name: Hepatitis C Virus-Related Hepatocellular Carcinoma

description: A hepatocellular carcinoma that develops following hepatitis C virus exposure and injury of the liver parenchyma.


name: BCLC Stage 0 Adult Hepatocellular Carcinoma

description: Very early hepatocellular carcinoma. Patients are optimal candidates for resection. (HPB (Oxford) 2005; 7(1):35-41)


name: Localized Non-Resectable Adult Liver Carcinoma

description: A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is not amenable to surgical resection.


Recurrent Childhood Liver Cancer

description: A malignant neoplasm of the liver that occurs during childhood and has recurred after a period of remission.


Liver Yolk Sac Tumor

description: A yolk sac tumor that arises from the liver.


Stage I Liver Carcinoma

description: Stage I carcinoma of the liver according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


name: Colorectal Adenocarcinoma Metastatic in the Liver

description: An adenocarcinoma that originates from the colorectal area and has spread to the liver.


name: Stage IV Hepatocellular Carcinoma AJCC v8

description: Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Postsurgical Stage IV Hepatoblastoma

description: Distant metastases, regardless of the extent of liver involvement. (from PDQ 2004)


name: Localized Childhood Hepatoblastoma by Toronto Guidelines v2, Tier1

description: Tumor confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Small Cell Undifferentiated Hepatoblastoma

description: A hepatoblastoma composed exclusively of noncohesive sheets of small undifferentiated cells. Cases showing loss of INI1 nuclear staining should be classified as rhabdoid tumors.


name: Metastatic Childhood Hepatoblastoma by Toronto Guidelines v2, Tier 2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Postsurgical Stage I Hepatoblastoma

description: No metastases, tumor completely resected. (from PDQ 2004)


name: Well Differentiated Hepatocellular Carcinoma

description: A hepatocellular carcinoma characterized by the presence of malignant cells with mild atypia and an increased nuclear/cytoplasmic ratio forming thin trabecular patterns.  It is usually associated with small tumors and an early stage.


name: Stage IB Intrahepatic Bile Duct Cancer AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 5 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Childhood Fibrolamellar Carcinoma

description: A fibrolamellar variant of hepatocellular carcinoma that occurs during childhood.


name: Stage IVA Hepatocellular Carcinoma AJCC v8

description: Stage IVA includes: Any T, N1, M0. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: BCLC Stage A Adult Hepatocellular Carcinoma

description: Early hepatocellular carcinoma.  Patients are candidates for radical therapies (resection, liver transplantation, or percutaneous treatments). (HPB (Oxford) 2005; 7(1):35-41)


Metastatic Hepatoblastoma

description: Hepatoblastoma that has spread from its original site of growth to another anatomic site.


name: Childhood Hepatoblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood hepatoblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Stage II Adult Liver Cancer AJCC v7

description: For hepatocellular carcinoma: Stage II includes: T2, N0, M0. T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage II includes: T2, N0, M0. T2: Solitary tumor with vascular invasion or multiple tumors, with or without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


name: Stage III Childhood Hepatocellular Carcinoma AJCC v7

description: Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Hepatoblastoma by PRETEXT Stage

description: A term that refers to the staging of hepatoblastoma, following the rules of the PRETEXT (pre-treatment extent of tumor) system.


Localized PRETEX I Hepatoblastoma

description: PRETEX I hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hepatoblastoma resectable

description: Hepatoblastoma amenable to surgical removal.


name: Stage IVB Hepatocellular Carcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Hepatocellular Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 7th edition.


name: Stage IIIB Hepatocellular Carcinoma AJCC v8

description: Stage IIIB includes: T4, N0, M0. T4: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein, or tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Localized Unresectable Adult Hepatocellular Carcinoma

description: A localized hepatocellular carcinoma that occurs during adulthood and it is not amenable to surgical resection.


Adult Fibrolamellar Carcinoma

description: Fibrolamellar variant of hepatocellular carcinoma that occurs during adulthood.


name: Poorly Differentiated Hepatocellular Carcinoma

description: A hepatocellular carcinoma characterized by the presence of malignant pleomorphic cells forming solid patterns.


Recurrent Fibrolamellar Carcinoma

description: The reemergence of fibrolamellar carcinoma after a period of remission.


undifferentiated carcinoma of liver

description: A rare carcinoma that arises from the liver.  The diagnosis is made by immunohistochemical studies.  Morphologic studies alone cannot establish the diagnosis of carcinoma or further subclassify the malignant tumor.


description: A hepatocellular carcinoma that develops following alcohol-induced injury of the liver parenchyma.


name: Stage IVB Hepatocellular Carcinoma AJCC v7

description: Stage IVB includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


BCLC Stage C Hepatocellular Carcinoma

description: Advanced hepatocellular carcinoma.  Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41)


Stage I Adult Liver Cancer AJCC v7

description: For hepatocellular carcinoma: Stage I includes: T1, N0, M0. T1: Solitary tumor without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage I includes: T1, N0, M0. T1: Solitary tumor without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


Small Hepatocellular Carcinoma

description: Hepatocellular carcinoma measuring equal to or less than 2 cm in diameter. It includes early hepatocellular carcinoma and small progressed hepatocellular carcinoma.


Hepatoblastoma by Postsurgical Stage

description: A term that refers to the staging of hepatoblastoma according to post-operative findings.


Pleomorphic Hepatocellular Carcinoma

description: A morphologic variant of hepatocellular carcinoma, characterized by the presence of malignant cells which show marked variation in their size and shape. Bizarre mononuclear or multinucleated giant cells are often present.


name: Stage IIIB Hepatocellular Carcinoma AJCC v7

description: Stage IIIB includes: T3b, N0, M0. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage III Adult Liver Cancer AJCC v7

description: For hepatocellular carcinoma: Stage III includes: IIIA: (T3a, N0, M0); IIIB: (T3b, N0, M0); IIIC: (T4, N0, M0). T3a: Multiple tumors more than 5 cm. T3b: Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein. T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis.  For intrahepatic cholangiocarcinoma: Stage III includes: T3, N0, M0. T3: Tumor perforating the visceral peritoneum or involving the local extra hepatic structures by direct invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 7th Ed.)


name: large cell neuroendocrine carcinoma of liver

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver. It is characterized by the presence of malignant large cells.


PRETEXT I Hepatoblastoma

description: An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves only 1 quadrant; 3 adjoining liver quadrants are free of tumor. (from PDQ 2004)


name: Hepatocellular Carcinoma by AJCC v6 Stage

description: A term that refers to the staging of hepatocellular carcinoma according to the American Joint Committee on Cancer, 6th edition.


Childhood Liver Angiosarcoma

description: An angiosarcoma that arises from the liver during childhood. Most cases arise within preexisting liver infantile hemangiomas.


Epithelial Hepatoblastoma

description: A subtype of hepatoblastoma characterized by the presence of an epithelial component and absence of mesenchymal elements. It includes hepatoblastoma with pure fetal epithelial differentiation, hepatoblastoma with combined fetal and embryonal epithelial differentiation, macrotrabecular hepatoblastoma, and small cell undifferentiated hepatoblastoma (small cell undifferentiated hepatoblastoma with loss of INI1 nuclear staining should be classified as rhabdoid tumor).


Hepatocellular Carcinoma by BCLC Stage

description: A staging classification system for hepatocellular carcinoma that uses variables related to tumor stage, liver functional status, physical status, and cancer-related symptoms, and links the stages with a treatment algorithm. (HPB (Oxford) 2005; 7(1):35-41)


name: Metastatic Childhood Hepatoblastoma by Toronto Guidelines v2, Tier 1

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hepatoblastoma non-resectable

description: Hepatoblastoma not amenable to surgical removal.


name: Intrahepatic Bile Duct Cancer by AJCC v8 Stage

description: A term that refers to the staging of intrahepatic bile duct cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to intrahepatic cholangiocarcinomas, combined hepatocellular-cholangiocarcinomas (mixed hepatocholangiocarcinomas), and primary neuroendocrine tumors of the liver. Primary sarcomas of the liver, pure hepatocellular carcinomas, hilar cholangiocarcinomas, and gallbladder carcinomas are not staged using this staging system. (from AJCC 8th Ed.)


name: Stage III Intrahepatic Bile Duct Cancer AJCC v8

description: Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); (Any T, N1, M0). T3: Tumor perforating the visceral peritoneum. T4: Tumor involving local extrahepatic structures by direct invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Chromophobe Hepatocellular Carcinoma

description: Hepatocellular carcinoma characterized by the presence of malignant cells with smooth chromophobic cytoplasm, abrupt focal nuclear anaplasia, and scattered microscopic pseudocysts.


Recurrent Hepatocellular Carcinoma

description: The reemergence of hepatocellular carcinoma after a period of remission


BCLC Stage A Hepatocellular Carcinoma

description: Early hepatocellular carcinoma.  Patients are candidates for radical therapies (resection, liver transplantation, or percutaneous treatments). (HPB (Oxford) 2005; 7(1):35-41)


Refractory Liver Carcinoma

description: Liver carcinoma that is resistant to treatment.


Stage IVB Liver Cancer

description: Stage IVB carcinoma of the liver according to the American Joint Committee on Cancer, 7th and 8th editions.


Metastatic PRETEX III Hepatoblastoma

description: PRETEX III hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Refractory Hepatocellular Carcinoma

description: Hepatocellular carcinoma that is resistant to treatment.


Localized PRETEX II Hepatoblastoma

description: PRETEX II hepatoblastoma confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Metastatic carcinoma to liver

description: A carcinoma that has spread to the liver from another primary anatomic site.  Representative examples include metastatic carcinomas from the colon, breast, and lung.


name: Localized Childhood Hepatoblastoma by Toronto Guidelines v2, Tier 2

description: Tumor confined to the liver including regional lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Early Hepatocellular Carcinoma

description: A low grade, well differentiated small hepatocellular carcinoma. It lacks obvious stromal invasion and significant atypia.


Metastatic PRETEX IV Hepatoblastoma

description: PRETEX IV hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Liver Plasmacytoma

description: A plasmacytoma that arises in the liver.


name: Stage II Hepatocellular Carcinoma AJCC v6 and v7

description: Stage II includes: T2, N0, M0.  T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


description: A rare type of hepatocellular carcinoma characterized by the presence of pleomorphic malignant cells that are intermixed with lymphocytes.


name: Stage III Hepatocellular Carcinoma AJCC v6

description: Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); IIIC: (Any T, Any N, M0).  IIIA: T3: Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s).  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


PRETEXT II Hepatoblastoma

description: An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 2 adjoining quadrants; 2 adjoining quadrants are free of tumor. (from PDQ 2004)


Stage IV Adult Liver Cancer AJCC v7

description: For hepatocellular carcinoma: Stage IV includes: IVA: (Any T, N1, M0); IVB: (Any T, Any N, M1). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis.  For intrahepatic cholangiocarcinoma: Stage IVA includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor with periductal invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis.  Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 7th Ed.)


Unresectable Hepatocellular Carcinoma

description: A hepatocellular carcinoma that is not amenable to surgical resection.


name: Hepatoblastoma with Combined Fetal and Embryonal Epithelial Differentiation

description: A hepatoblastoma composed of cells resembling fetal epithelial cells and small round cells resembling blastema cells.


name: Rectal Carcinoma Metastatic in the Liver

description: A carcinoma that originates from the rectum and has spread to the liver.


name: Adult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

description: A combined hepatocellular carcinoma and cholangiocarcinoma that occurs during adulthood.


name: Stage IIIA Hepatocellular Carcinoma AJCC v8

description: Stage IIIA includes: T3, N0, M0. T3: Multiple tumors, at least one of which is larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIIC Hepatocellular Carcinoma AJCC v7

description: Stage IIIC includes: T4, N0, M0.  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Childhood Malignant Liver Neoplasm

description: A malignant neoplasm that affects the liver and occurs during childhood.


name: BCLC Stage D Adult Hepatocellular Carcinoma

description: End-stage hepatocellular carcinoma.  Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)


name: Macrotrabecular Massive Hepatocellular Carcinoma

description: Hepatocellular carcinoma characterized by more than 50% growth of macrotrabecular pattern (equal to or more than 6 to 10 cells thick). It presents with higher grade and stage compared to conventional hepatocellular carcinoma. It has poor prognosis with early recurrence and poor overall survival.


name: Stage II Childhood Hepatocellular Carcinoma AJCC v6 and v7


Metastatic PRETEX II Hepatoblastoma

description: PRETEX II hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Early Stage Hepatocellular Carcinoma

description: A stage term referring to hepatocellular carcinoma that presents as a single tumor with the largest diameter measuring 2 cm or less. The liver function is well-preserved and there is no vascular invasion or metastasis. (Barcelona Liver Cancer Classification).


name: Stage IIIB Intrahepatic Bile Duct Cancer AJCC v8

description: Stage IIIB includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor involving local extrahepatic structures by direct invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


description: Hepatocellular carcinoma characterized by the presence of steatohepatitis features, including macrovesicular steatosis, fibrosis, ballooning of malignant hepatocytes, Mallory bodies, and inflammation.


name: Colorectal Carcinoma Metastatic in the Liver

description: A carcinoma that originates from the colorectal area and has spread to the liver.


Metastatic PRETEX I Hepatoblastoma

description: PRETEX I hepatoblastoma with distant metastases. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Small Progressed Hepatocellular Carcinoma

description: A well to moderately differentiated small hepatocellular carcinoma. It is characterized by the presence of obvious stromal invasion and increase atypia compared with early hepatocellular carcinoma.


Recurrent Adult Liver Carcinoma

description: A hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and has recurred after a period of remission.


Grade 3 Joint Infection, CTCAE

description: Arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage)


name: Grade II Prostatic Intraepithelial Neoplasia

description: High grade prostatic intraepithelial neoplasia characterized by the presence of moderate architectural and cytologic abnormalities.


name: Testicular Tumor of the Thecoma/Fibroma Group

description: A group of rare, slow-growing stromal tumors that arise from the testis.  This category includes thecoma and fibroma.


Testicular Signet Ring Stromal Tumor

description: An extremely rare tumor that arises from the testis. It is characterized by the proliferation of epithelioid cells with signet ring appearance separated by fibrous tissue into trabeculae and nests. The histologic features are bland and there is no mucin production. Mutations of CTNNB1 gene have been identified in the reported cases. It is considered a special type of sex cord-stromal tumor. All reported cases had a benign clinical course without metastases.


name: recurrent childhood acute myeloid leukemia

description: The reemergence of acute myeloid leukemia in childhood after a period of remission.


Grade 4 Uterine Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Childhood Unfavorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis that occurs during childhood.


Acquired Factor III Deficiency

description: An acquired coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III deficiency

description: A coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


Factor III Inactivation

description: Presence of inactivating antibodies to tissue factor (factor III) in the blood.


Hereditary Factor III Deficiency

description: An autosomal recessive, inherited coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood.


name: Grade 4 Nodal or Junctional Rhythm, CTCAE


Acardius

description: A severe form of twin-twin transfusion syndrome that occurs in monochorionic pregnancies. The normal twin (pump twin) supplies the blood flow to its sibling that lacks heart or brain or both (acardiac/acephalic twin). Untreated, it may lead to the demise of the pump twin in some cases.


Suture Abrasion

description: Wearing away of the surface of a suture as a result of bending and frictional forces.


skin abrasion

description: Superficial damage to the skin caused by rubbing or scraping.


Parkinson Disease 9

description: An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the ATP13A2 gene, encoding polyamine-transporting ATPase 13A2.


name: Parkinson Disease 23, Autosomal Recessive, Early Onset

description: An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the VPS13C gene, encoding intermembrane lipid transfer protein VPS13C.


Parkinson Disease 20, Early-Onset

description: An autosomal recessive subtype of Parkinson disease, caused by mutation(s) in the SYNJ1 gene, encoding synaptojanin-1.


Grade 5 Necrotizing Enterocolitis, AE

description: A necrotizing enterocolitis adverse event in a newborn which results in death.


name: Grade 3 Jugular Vein Intra-Operative Injury, CTCAE


Benign neoplasm of supraglottis

description: A neoplasm that arises from the supraglottis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Childhood Acute Myeloid Leukemia without Maturation

description: An acute myeloid leukemia without maturation occurring in children.


Grade 3 Tracheal Fistula, CTCAE

description: Invasive intervention indicated


name: Pulmonary and Upper Respiratory Fistula, CTCAE


Grade 3 Laryngeal Fistula, CTCAE

description: Invasive intervention indicated


name: Grade 1 Oral Cavity Pulmonary Fistula, CTCAE


Grade 2 Laryngeal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Grade 3 Oral Cavity Pulmonary Fistula, CTCAE


Laryngeal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the larynx and another organ or anatomic site.


name: Grade 4 Pharynx Pulmonary Fistula, CTCAE


name: Grade 4 Oral Cavity Pulmonary Fistula, CTCAE


Tracheal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the trachea and another organ or anatomic site.


Grade 5 Laryngeal Fistula, CTCAE

description: Death


Grade 4 Laryngeal Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Oral Cavity Pulmonary Fistula, CTCAE


name: Grade 5 Pharynx Pulmonary Fistula, CTCAE


name: Grade 3 Pharynx Pulmonary Fistula, CTCAE


Grade 1 Laryngeal Fistula, CTCAE

description: Asymptomatic


Grade 1 Tracheal Fistula, CTCAE

description: Asymptomatic


name: Grade 2 Pharynx Pulmonary Fistula, CTCAE


name: Grade 1 Pharynx Pulmonary Fistula, CTCAE


Parasite-Related Carcinoma

description: A term that refers to a group of carcinomas that are caused by parasites.


name: Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma

description: A squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


name: Schistosoma Hematobium-Related Bladder Verrucous Carcinoma

description: A verrucous squamous cell carcinoma of the bladder that is caused by Schistosoma hematobium.


name: Metastatic malignant neoplasm to choroid

description: A malignant neoplasm that has spread to the choroid from another anatomic site.


Gallbladder Soft Tissue Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm that arises from the gallbladder.


Childhood Osteochondroma

description: An osteochondroma that occurs during childhood.


Osteochondromatosis

description: An autosomal dominant neoplastic chondrogenic process affecting multiple sites. It is caused by mutations in the EXT1 or EXT2 genes.  Grossly and microscopically, the lesions resemble an osteochondroma.


Maxillofacial Osteochondroma

description: A rare osteochondroma that arises from a maxillofacial bone.


Childhood Chondroblastoma

description: A chondroblastoma that occurs during childhood.


Maxillofacial Chondroblastoma

description: A benign chondroid-producing neoplasm arising in a maxillofacial bone.


Jaw Chondromyxoid Fibroma

description: A chondromyxoid fibroma that arises from the jaw.


Laryngeal Chondroma

description: A benign neoplasm arising from hyaline cartilage of the larynx. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Maxillofacial Chondroma

description: A benign neoplasm of hyaline cartilage that arises within the medullary cavity of a maxillofacial bone. It is characterized by the presence of chondrocytes, a lobulated growth pattern, and calcification.


Childhood Chondromyxoid Fibroma

description: A chondromyxoid fibroma that occurs during childhood.


Childhood Subungual Exostosis

description: Subungual exostosis that occurs during childhood.


Maxillofacial Chondromyxoid Fibroma

description: An uncommon benign cartilaginous neoplasm arising in a maxillofacial bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells.


Chondromatosis

description: A multifocal benign neoplasm arising from bone or soft tissue.  It is characterized by the presence of chondrocytes and is composed of hyaline cartilage.


name: Bizarre parosteal osteochondromatous proliferation

description: A benign lesion that usually affects the proximal small bones of the hands or feet.  Grossly it consists of a cartilage cap and a bony stalk.  Microscopically it is characterized by the presence of spindle cells, cartilage, and bone, usually in a disorganized pattern compared to subungual exostosis.  Enlarged (bizarre) chondrocytes are present in the cartilage.  Swelling with or without pain is present.  Recurrences following resection have been reported in approximately half of cases.


Solitary Osteochondroma

description: An osteochondroma affecting a single anatomical site.


hemisuccinate

A succinate ester in which only one of the carboxy groups of succinic acid has been esterified.


Uterine Obstruction

description: Blockage of the uterine outlet. Causes include uterine tumors and adhesions.


Tactile Disorder

description: Conditions characterized by an alteration in the ability to perceive touch.


Refractory Lymphoma

description: A lymphoma that does not respond to treatment.


name: Refractory Central Nervous System Lymphoma

description: Central nervous system lymphoma that is resistant to treatment.


Refractory Primary Cutaneous Lymphoma

description: Primary cutaneous lymphoma that does not respond to treatment.


Refractory EBV-Related Lymphoma

description: EBV-related lymphoma that is resistant to treatment.


name: Hodgkin's disease mixed cellularity refractory

description: Mixed cellularity classic Hodgkin lymphoma that is resistant to treatment.


Classical Hodgkin lymphoma refractory

description: Classic Hodgkin lymphoma that is resistant to treatment.


Refractory Primary Bone Lymphoma

description: Primary lymphoma of bone that is resistant to treatment.


Refractory Hodgkin Lymphoma

description: Hodgkin lymphoma resistant to treatment


name: Hodgkin's disease nodular sclerosis refractory

description: Nodular sclerosis classic Hodgkin lymphoma that is resistant to treatment.


name: Refractory Lymphocyte-Rich Classic Hodgkin Lymphoma

description: Lymphocyte-rich classic Hodgkin lymphoma that does not respond to treatment.


name: Hodgkin's disease lymphocyte depletion type refractory

description: Lymphocyte-depleted classic Hodgkin lymphoma that is resistant to treatment.


Sinonasal Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the nasal cavity or paranasal sinuses.


Head and Neck Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the larynx.


Sinonasal Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the sinonasal tract.


Head and Neck Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the head and neck.


Paranasal Sinus Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the paranasal sinuses.


Paranasal Sinus Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the paranasal sinuses.


Nasal Cavity Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the nasal cavity.


Nasal Cavity Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the nasal cavity.


Laryngeal Neuroendocrine Tumor

description: A well-differentiated, low or intermediate grade neuroendocrine neoplasm that arises from the larynx.


Nasal Cavity Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the nasal cavity.


Sinonasal Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the nasal cavity or paranasal sinuses.


Head and Neck Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the head and neck.


Laryngeal Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the larynx.


name: Grade 4 Intestinal Stoma Obstruction, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Refractory Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that is resistant to treatment.


name: 18,25-dihydroxyvitamin D3 / 18,25-dihydroxycholecalciferol


vitamin D4

It is present in mushrooms.


name: 1alpha,25-dihydroxy-11alpha-methoxyvitamin D3 / 1alpha,25-dihydroxy-11alpha-methoxycholecalciferol


name: 1alpha,25-dihydroxy-2beta-(6-hydroxyhexyl)vitamin D3 / 1alpha,25-dihydroxy-2beta-(6-hydroxyhexyl)cholecalciferol


name: 1,25-dihydroxy-22-oxavitamin D3 3-hemiglutarate/ 1,25-dihydroxy-22-oxacholecalciferol 3-hemiglutarate


name: (6R)-vitamin D2 6,19-sulfur dioxide adduct / (6R)-ergocalciferol 6,19-sulfur dioxide adduct


previtamin D3

A hydroxy seco-steroid which is an intermediate in the production of vitamin D3 in human skin.


23(S),25-dihydroxy-24-oxovitamin D3

A hydroxycalciol that is 25-hydroxyvitamin D3 carrying an additional hydroxy group at position 23 (with 23S-configuration) and an oxo group at position 24. An intermediate in the degradation pathway of 25-OH-vitamin D3.


name: 24-(dimethoxyphosphoryl)-25,26,27-trinorvitamin D3 / 24-(dimethoxyphosphoryl)-25,26,27-trinorcholecalciferol


name: 24-fluoro-25-hydroxyvitamin D3 / 24-fluoro-25-hydroxycholecalciferol


(20S,24S)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 and 24 (both with S-configuration).


name: 2alpha-chloro-1beta,25-dihydroxyvitamin D3 / 2alpha-chloro-1beta,25-dihydroxycholecalciferol


name: (20S)-1alpha,20,25-trihydroxy-24a-homovitamin D3 / (20S)-1alpha,20,25-trihydroxy-24a-homocholecalciferol


name: (6R)-vitamin D3 6,19-(4-phenyl-1,2,4-triazoline-3,5-dione) adduct


name: (24R)-6,19-epidioxy-1,24-dihydroxy-6,19-dihydrovitamin D3 / (24R)-6,19-epidioxy-1,24-di hydroxy-6,19-dihydrocholecalciferol


name: 1alpha,25-dihydroxy-24-oxo-23-azavitamin D2 / 1alpha,25-dihydroxy-24-oxo-23-azaergocalciferol


name: (24R,25S)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24R,25S)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


name: (23R)-1alpha,23,25-trihydroxy-23-methylvitamin D3 / (23R)-1alpha,23,25-trihydroxy-23-methylcholecalciferol


name: 25-hydroxy-16,17-didehydrovitamin D3 / 25-hydroxy-16,17-didehydrocholecalciferol


name: 1alpha,25-dihydroxy-18-oxovitamin D3 / 1alpha,25-dihydroxy-18-oxocholecalciferol


calcidiol 3-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 3 has been replaced by a beta-D-glucuronyl residue.


name: 1alpha,25-dihydroxy-11alpha-(hydroxymethyl)vitamin D3 / 1alpha,25-dihydroxy-11alpha-(hydroxymethyl)cholecalciferol


name: 1alpha,24,25,28-tetrahydroxyvitamin D2 / 1alpha,24,25,28-tetrahydroxyergocalciferol


name: 1alpha,25-dihydroxy-(26,26)-(27,27)-diethanovitamin D3 / 1alpha,25-dihydroxy-(26,26)-(27,27)-diethanocholecalciferol


1,24(S)-dihydroxyvitamin D2

Metabolite of vitamin D2. It  present in the circulation of humans, cows, and rats given pharmacologic doses of vitamin D2


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity.


(20S)-hydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying an additional hydroxy group at position 20 with S-configuration.


18-acetoxy-1alpha-hydroxyvitamin D3

A hydroxycalciol that is calciol with an additional hydroxy group at position C-1 and an acetoxy group at C-18.


name: 1alpha,25-dihydroxy-24a,24b-dihomo-23-oxavitamin D3 / 1alpha,25-dihydroxy-24a,24b-dihomo-23-oxacholecalciferol


(20S,23)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 23.


name: (25R)-26,26,26-trifluoro-1alpha,25-dihydroxyvitamin D3 / (25R)-26,26,26-trifluoro-1alpha,25-dihydroxycholecalciferol


name: 1alpha-Hydroxy-25,26,27-trinorvitamin D3 24-carboxylic acid


name: 1alpha,25-dihydroxy-20-epivitamin D2 / 1alpha,25-dihydroxy-20-epiergocalciferol


name: (23Z)-25-hydroxy-16,17,23,24-tetradehydrovitamin D3 / (23Z)-25-hydroxy-16,17,23,24-tetradehydrocholecalciferol


name: (23S,25R)-25-hydroxyvitamin D3 26,23-lactol / (23S,25R)-25-hydroxycholecalciferol 26,23-lactol


vitamin D5

A vitamin D in which the side-chain at position 17 consists of a (5R)-5-ethyl-6-methylheptan-2-yl group.


name: (10e)-19-(3-carboxylpropyl)vitamin d3 / (10e)-19-(3-carboxylpropyl)cholecalciferol


name: (20S)-1alpha,25-dihydroxy-20-methoxyvitamin D3 / (20S)-1alpha,25-dihydroxy-20-methoxycholecalciferol


name: 1alpha,25-dihydroxy-24a,24b-dihomo-22-oxavitamin D3 / 1alpha,25-dihydroxy-24a,24b-dihomo-22-oxacholecalciferol


name: (24R)-1alpha,24,25,26-tetrahydroxyvitamin D2 / (24R)-1alpha,24,25,26-tetrahydroxyergocalciferol


name: (24S,25S)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24S,25S)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


name: 23,23-difluoro-1alpha,25-dihydroxyvitamin D3 / 23,23-difluoro-1alpha,25-dihydroxycholecalciferol


name: 1alpha,25-dihydroxy-24a-homo-22-thiavitamin D3 / 1alpha,25-dihydroxy-24a-homo-22-thiacholecalciferol


name: 1alpha,25-Dihydroxyvitamin D3 25-trimethylsilyl ether


name: (24S,25R)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24S,25R)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


1alpha,2beta,25-trihydroxy vitamin D3

A hydroxy seco-steroid that is calciol carrying three additional hydroxy substituents at positions 1alpha, 2beta and 25.


A hydroxycalciol that is a synthetic analogue of vitamin D3 which contains an oxolane ring and exhibits weak vitamin D receptor agonist activity


D3 vitamins

A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.


A hydroxycalciol that is calcitriol with an acetoxy group at C-18.


name: 1alpha,25-dihydroxy-24-nor-22-oxavitamin D3 / 1alpha,25-dihydroxy-24-nor-22-oxacholecalciferol


A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group.


5,6-trans-vitamin D3

A member of the class of D3 vitamins that is calciol in which the double bond at position 5 adopts a trans-configuration. During exposure to sunlight, previtamin D3 and vitamin D3 in the skin become photoisomerized to 5,6-trans-vitamin D3.


(20S,24R)-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration) and 24 (with R-configuration).


20(S),25-dihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration) and 25.


ERCALCITRIOL

A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.


name: 26,26,26-trifluoro-25-hydroxyvitamin D3 / 26,26,26-trifluoro-25-hydroxycholecalciferol


calcidiol 25-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcidiol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


name: 1alpha,25-dihydroxy-11beta-methoxyvitamin D3 / 1alpha,25-dihydroxy-11beta-methoxycholecalciferol


name: (24R,25R)-25,26-epoxy-1alpha,24-dihydroxyvitamin D3 / (24R,25R)-25,26-epoxy-1alpha,24-dihydroxycholecalciferol


Grade 2 Jejunal Obstruction, CTCAE

description: Symptomatic; altered GI function; limiting instrumental ADL


name: Grade 2 Head Soft Tissue Necrosis, CTCAE

description: Local wound care; medical intervention indicated (e.g., dressings or topical medications)


Splenic Plasmacytoma

description: A plasmacytoma that arises in the spleen.


name: Splenic B-Cell Lymphoma/Leukemia, Unclassifiable

description: A small B-cell clonal lymphoproliferative disorder of the spleen that does not fall into any of the other categories of mature B-cell neoplasms.


Malignant Splenic Soft Tissue Neoplasm

description: A malignant mesenchymal neoplasm that arises from the spleen.


Recurrent Hairy Cell Leukemia Variant

description: The reemergence of hairy cell leukemia variant after a period of remission.


name: Splenic Manifestation of Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Infiltration and expansion of the red pulp and sinusoids of the spleen by chronic myeloid leukemia, BCR-ABL1 positive.


name: Splenic Manifestation of B-Cell Prolymphocytic Leukemia

description: Infiltration and expansion of the white and red pulp of the spleen by B-cell prolymphocytic leukemia.


name: Extramedullary Disease in Multiple Myeloma Involving the Spleen

description: Infiltration of the spleen by malignant (clonal) plasma cells in patients with history of multiple myeloma


name: Sclerosing angiomatoid nodular transformation of spleen

description: A benign, circumscribed lesion that arises from the spleen and is composed of multiple angiomatoid nodules in a fibrosclerotic stroma. It most often affects middle-aged females. It is usually asymptomatic, and most cases are detected incidentally on imaging studies.


name: Splenic Manifestation of T-Cell Prolymphocytic Leukemia

description: Infiltration and expansion of the white and red pulp of the spleen by T-cell prolymphocytic leukemia.


Malignant lymphoma of spleen

description: A non-Hodgkin lymphoma or rarely Hodgkin lymphoma that arises from the spleen.


name: Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

description: Infiltration and expansion of the red pulp cords and sinusoids of the spleen by T-cell large granular lymphocyte leukemia. The white pulp of the spleen is not involved and is often hyperplastic.


thiazolidinediones

A thiadiazolidine in which the 1,3-thiazolidine ring is substituted by two oxo groups.


Paratesticular Paraganglioma

description: An extremely rare paraganglioma that arises from the paratesticular structures.


name: Hematologic Neoplasm with Germline Predisposition Associated with a Constitutional Disorder Affecting Multiple Organ Systems

description: Familial hematologic neoplasms associated with germline mutations and a preexisting disorder or organ dysfunction other than a platelet disorder.


name: Hematologic Neoplasm with Germline Predisposition Associated with Inherited Bone Marrow Failure Syndrome

description: Familial myelodysplastic syndromes/ acute myeloid leukemias associated with inherited bone marrow failure syndromes.


name: Hematologic Neoplasm with Germline GATA2 Mutation

description: Myelodysplastic syndromes/acute myeloid leukemias associated with germline GATA2 mutation.


name: Hematologic Neoplasm with Germline SAMD9 Mutation

description: Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9 mutation.


name: Hematologic Neoplasm with Germline SAMD9L Mutation

description: Myelodysplastic syndromes/acute myeloid leukemias associated with germline SAMD9L mutation.


name: Juvenile Myelomonocytic Leukemia Associated with Neurofibromatosis

description: Juvenile myelomonocytic leukemia that is associated with neurofibromatosis type 1 (NF1).


name: Juvenile Myelomonocytic Leukemia Associated with Noonan Syndrome-Like Disorder

description: Juvenile myelomonocytic leukemia that is associated with a genetic disorder caused by germline mutations in the CBL gene and phenotypically resembles Noonan syndrome (Noonan syndrome-like disorder).


name: Hematologic Neoplasm Associated with Down Syndrome

description: Hematologic neoplasms occurring in individuals with Down syndrome.  There is an increased risk of acute leukemias in both children and adults with Down syndrome.  In particular, the incidence of acute myeloid leukemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.  This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.


name: Hematologic Neoplasm with Germline Predisposition Associated with Telomerase Biology Disorder

description: Familial myelodysplastic syndromes/ acute myeloid leukemias associated with telomerase biology disorders.


Serous Tubal Intraepithelial Lesion

description: A non-invasive, precursor epithelial proliferation that arises from the fallopian tube, lacks severe atypia, and demonstrates serous differentiation.


Fracture of Ulna Related to Birth

description: A broken ulna sustained during the birthing process.


Closed Monteggia's fracture

description: Proximal radial head dislocation in association with a proximal ulnar fracture that does not involve a break in the adjacent skin.


Fracture of Clavicle Related to Birth

description: An injury sustained during the birthing process in which the continuity is broken in the clavicle.


Fracture of Femur Related to Birth

description: A broken femur sustained during the birthing process.


Closed fracture of rib

description: A traumatic break in one of the bones in the rib cage that does not involve a break in the adjacent skin.


Fracture of metacarpal bone

description: A traumatic break in one or more of the metacarpal bones.


name: Closed fracture of shaft of metacarpal bone

description: A traumatic break in the diaphysis of the metacarpal bone that does not involve a break in the adjacent skin.


Closed fracture of multiple ribs

description: A traumatic break in two or more places in one rib, or a traumatic break in more than one rib, that does not involve a break in the adjacent skin.


Closed fracture of pelvis

description: A traumatic break in one or more of the bones comprising the bony structure of the pelvis that does not involve a break in the adjacent skin.


Open fracture of rib

description: A traumatic break in one of the bones in the rib cage  that involves a break in the adjacent skin.


Closed fracture of metacarpal bone

description: A traumatic break in one or more of the metacarpal bones that does not involve a break in the adjacent skin.


Fracture of mandible, closed

description: A traumatic break in the mandible  that does not involve a break in the adjacent skin.


name: Closed fracture of malar AND/OR maxillary bones

description: A traumatic break in the malar and maxillary bones  that does not involve a break in the adjacent skin.


Fracture Related to Birth

description: A broken bone sustained during the birthing process.


name: Closed fracture of neck of metacarpal bone

description: A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that does not involve a break in the adjacent skin.


Fracture of bone involving growth plate

description: A traumatic break in a long bone that involves the epiphyseal plate.


Lumbar vertebral fracture L2

description: A traumatic break in the second lumbar spinal vertebra.


Fracture of Humerus Related to Birth

description: A broken humerus sustained during the birthing process.


Fracture of phalanx of finger

description: A traumatic break in one or more of the bones in one of the digits of the hand.


name: Open fracture of neck of metacarpal bone

description: A traumatic break in the area of the metacarpal bone located between the diaphysis and the distal metaphysis that involves a break in the adjacent skin.


Closed Colles' fracture

description: An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment that does not involve a break in the adjacent skin.


Fracture of Spine Related to Birth

description: A broken vertebra sustained during the birthing process.


Fracture of Radius Related to Birth

description: A broken radius sustained during the birthing process.


Colles' Fracture

description: An extra-articular traumatic break in the distal radius with dorsal displacement of the distal fragment.


Open fracture of pelvis

description: A traumatic break in one or more of the bones comprising the bony structure of the pelvis that involves a break in the adjacent skin..


Fracture of Skull Related to Birth

description: An injury sustained during the birthing process in which the continuity is broken in the skull.


Limb fracture

description: A traumatic break in one or more bones in a limb.


Open fracture of metacarpal bone

description: A traumatic break in one or more of the metacarpal bones that involves a break in the adjacent skin.


Fracture of Nose Related to Birth

description: A broken nasal bone sustained during the birthing process.


Grade 2 Vaginal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Parotid Gland Lymphangioma

description: A lymphangioma arising from the parotid gland.


dichlorobenzene

Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.


ISOCONAZOLE

A member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1.


(S)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (S)-enantiomer of fenticonazole.


(S)-econazole

A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of econazole.


(S)-butoconazole

The (S)-enantiomer of butoconazole.


(S)-tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of tioconazole.


(R)-econazole

A 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of econazole.


(R)-fenticonazole

A 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole that is the (R)-enantiomer of fenticonazole.


(S)-miconazole

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration.


(S)-enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (S)-enantiomer of enilconazole


(R)-enilconazole

A 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that is the (R)-enantiomer of enilconazole.


ARASERTACONAZOLE

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the active R-enantiomer of sertaconazole and is used (as its nitrate salt) for treatment of vulvovaginal candidiasis. The racemate itself is also used as a broad-spectrum antifungal drug.


(R)-butaconazole

The (R)-enantiomer of butaconazole.


(R)-MICONAZOLE

A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration.


A salicylanilide derivative with chloride substituents at C-3 and C-5 of the salicylate moiety and at C-3 and C-4 of the anilide moiety.


(R)-tioconazole

A 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (R)-enantiomer of tioconazole.


(S)-sertaconazole

A 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole that is the (S)-enantiomer of sertaconazole.


A pyrazolylpiperidine that consists of 4-(pyrazol-1-yl)piperidine carrying a 2-amino-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-5-yl group at the 4-position of the pyrazole ring.


name: Stage IV Adrenal Cortex Carcinoma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


description: A sympathetic paraganglioma arising from the retroperitoneum, outside the adrenal gland.


Childhood Adrenal Cortical Carcinoma

description: A carcinoma that arises from the adrenal cortex and occurs during childhood.


Retroperitoneal Ganglioneuroma

description: A ganglioneuroma arising from the retroperitoneum.


name: Adrenal Cortical Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v7 classification system.


Adrenal Cortical Oncocytic Carcinoma

description: A carcinoma that arises from the adrenal cortex and is composed of oncocytic cells that constitute more than 90% of malignant cells.


name: Stage III Adrenal Cortex Carcinoma AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0); (T4, Any N, M0). T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. T3: Tumor of any size with local invasion but not invading adjacent organs. T4: Tumor of any size that invades adjacent organs (kidney, diaphragm, pancreas, spleen, or liver) or large blood vessels (renal vein or vena cava). N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (from AJCC 8th Ed.)


name: Adrenal Cortical Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of adrenal cortical carcinoma, following the rules of the TNM AJCC v8 classification system. Adrenal medullary pheochromocytoma is staged according to the classification for adrenal neuroendocrine tumors. There is no AJCC staging system for neuroblastic tumors of the adrenal gland. (from AJCC 8th Ed.)


Adrenal Cortical Oncocytic Adenoma

description: A usually non-functioning variant of adrenal cortex adenoma, composed of large cells with abundant granular eosinophilic cytoplasm.


name: Glomerulosa Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells.


name: Stage III Adrenal Cortex Carcinoma AJCC v7

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0).  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  T3: Tumor of any size with local invasion, but not invading adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Ganglioneuroma

description: A ganglioneuroma arising from the adrenal gland.


Adrenal Gland Lipoma

description: A rare lipoma that arises from the adrenal gland.


name: Recurrent Adrenal Gland Pheochromocytoma

description: The reemergence of pheochromocytoma following surgical removal.


Clear Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of neoplastic clear cells containing intracytoplasmic lipid droplets.


name: Stage IV Adrenal Cortex Carcinoma AJCC v7

description: Stage IV includes: (T3, N1, M0); (T4, N0, M0); (T4, N1, M0); (Any T, Any N, M1).  T3: Tumor of any size with local invasion, but not invading adjacent organs.  T4: Tumor of any size with invasion of adjacent organs.  N1: Metastasis in regional lymph node(s).  N0: No regional lymph node metastasis.  M0: No distant metastasis. M1: Distant metastasis.  (AJCC 7th ed.)


name: Retroperitoneal Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor that arises from the retroperitoneum. This is an extragastrointestinal tumor, meaning that it does not arise directly from the gastrointestinal tract.


Leiomyoma of the adrenal gland

description: A rare leiomyoma that arises from the adrenal gland.


Benign neoplasm of retroperitoneum

description: A neoplasm that arises from the retroperitoneum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Benign neoplasm of adrenal cortex

description: A neoplasm that arises from the adrenal cortex and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex that occurs during childhood.


name: Stage I Adrenal Cortex Carcinoma AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Hereditary Adrenal Gland Pheochromocytoma

description: A hereditary adrenal gland pheochromocytoma caused by mutations in SDHB, SDHC, and SDHD genes.


Adrenal Cortical Adenomatoid Tumor

description: A benign adrenal cortical neoplasm deriving from mesothelial cells.


name: Locally Advanced Adrenal Gland Pheochromocytoma

description: Adrenal gland pheochromocytoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Cortical Myxoid Carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the presence of abundant extracellular connective tissue mucin.


name: Locally Advanced Adrenal Cortical Carcinoma

description: Adrenal cortical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Adrenal Gland Lymphangioma

description: A rare lymphangioma that arises from the adrenal gland.


name: Stage II Adrenal Cortex Carcinoma AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor greater than 5 cm, no extra-adrenal invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adrenal Gland Lymphoma

description: A rare lymphoma that arises from the adrenal gland.


Adrenal Cortical Low Grade Carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the presence of twenty or less mitoses per ten square millimeters.


name: Metastatic Adrenal Gland Composite Pheochromocytoma

description: An adrenal gland composite pheochromocytoma that metastasizes to other anatomic sites.


Metastatic Adrenal Cortical Carcinoma

description: A carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site.


Adrenal Gland Hemangioma

description: A rare hemangioma that arises from the adrenal gland.


name: Superior and Inferior Paraaortic Paraganglioma

description: An extra-adrenal sympathetic paraganglioma arising from paraganglia located along the aorta, including suprarenal, infrarenal, and renal hilar sites.  In functional tumors, the hypersecretion of catecholamines results in hypertension.


name: Metastatic Carcinoma in the Adrenal Cortex

description: A carcinoma that has spread to the adrenal cortex from an adjacent or distal anatomic site.


name: Androgen-Producing Adrenal Cortical Adenoma

description: A rare adenoma of the adrenal cortex that produces androgens.  Female patients usually have symptoms related to virilism.


name: Unresectable Adrenal Gland Pheochromocytoma

description: Adrenal gland pheochromocytoma that is not amenable to surgical resection.


Compact Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic cytoplasm.


Adrenal Cortical Sex Cord-Stromal Tumor

description: An extremely rare sex cord-stromal tumor that arises from the adrenal cortex. The reported cases were solitary and unilateral.


name: Adrenal Gland Composite Pheochromocytoma

description: A neoplasm that arises from the adrenal medulla and combines morphologic characteristics of pheochromocytoma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor.


name: Adrenal Gland Ganglioneuroblastoma, Intermixed

description: An intermixed ganglioneuroblastoma arising from the adrenal gland.


Adrenal Cortical High Grade Carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the presence of more than twenty mitoses per ten square millimeters.


name: Stage I Adrenal Cortex Carcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 5 cm or less in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Advanced Adrenal Gland Pheochromocytoma

description: An adrenal gland pheochromocytoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adrenal Cortical Melanoma

description: A rare melanoma that arises within the adrenal cortex.


Adrenal Gland Schwannoma

description: A rare schwannoma that arises from the adrenal medulla.


Mixed Cell Adrenal Cortical Adenoma

description: An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, including varying numbers of neoplastic clear and compact cells.


name: Stage II Adrenal Cortex Carcinoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor measuring more than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Adrenal Gland Ganglioneuroblastoma, Nodular

description: A nodular ganglioneuroblastoma arising from the adrenal gland.


Unresectable Adrenal Cortical Carcinoma

description: Adrenal cortical carcinoma that is not amenable to surgical resection.


name: Recurrent Malignant Retroperitoneal Neoplasm

description: The reemergence of a malignant retroperitoneal neoplasm after a period of remission.


name: Non-Metastatic Adrenal Gland Composite Pheochromocytoma

description: A composite pheochromocytoma that is confined to the adrenal gland.


Regional Adrenal Gland Pheochromocytoma

description: A pheochromocytoma that has not spread to other regions.


name: Heavily Pigmented Adrenal Cortical Adenoma

description: A usually functioning adenoma of the adrenal cortex. Grossly, it has a dark brown appearance and is characterized by the presence of neoplastic cells containing abundant intracytoplasmic lipofuscin. It may be associated with Cushing syndrome.


Recurrent Adrenal Cortical Carcinoma

description: The reemergence of adrenal cortical carcinoma after a period of remission.


Anaplastic adrenocortical carcinoma

description: A carcinoma that arises from the adrenal cortex and is characterized by the partial or complete loss of adrenal cortical differentiation.


Refractory Adrenal Cortical Carcinoma

description: Adrenal cortical carcinoma that is resistant to treatment.


name: estrogen-producing adrenal cortical adenoma

description: A rare adenoma of the adrenal cortex that produces estrogens.  Male patients may develop gynecomastia and impotence.


Grade 1 Conjunctivitis, CTCAE

description: Asymptomatic or mild symptoms; intervention not indicated


name: Grade 5 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Acute Myeloid Leukemia with Complex Karyotype

description: Acute myeloid leukemia associated with at least 3 unrelated clonal chromosomal abnormalities.


Forceps Injury

description: Birth injury sustained during a forceps-assisted delivery.


Grade 5 Pericardial Tamponade, CTCAE

description: Death


name: Grade 1 Upper Extremity Vein Injury, CTCAE


name: Grade 4 Upper Extremity Vein Injury, CTCAE


name: Grade 2 Upper Extremity Vein Injury, CTCAE


name: Grade 5 Upper Extremity Vein Injury, CTCAE


name: Childhood Neuroblastoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood neuroblastoma according to the Toronto childhood cancer staging guidelines v2.


name: Familial Adenomatous Polyposis Associated Medulloblastoma

description: A medulloblastoma developing in patients with familiar adenomatous polyposis syndrome.  It is observed in patients with Turcot syndrome, type 2.


Medulloblastoma, SHH-4

description: Medulloblastoma, SHH-activated, characterized by mutations of U1-snRNA and TERT genes. Mutations of PTCH1 or SMO genes are usually also present. It affects mostly adults.


Sellar Neuroblastoma

description: A rare neuroblastoma arising from the sella turcica.


Refractory Ganglioneuroblastoma

description: Ganglioneuroblastoma that does not respond to treatment.


name: Embryonal Tumor with Multilayered Rosettes, DICER1-Mutated

description: An embryonal tumor with multilayered rosettes characterized by the presence of DICER1 mutation. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.


Refractory Dedifferentiated Chordoma

description: A dedifferentiated chordoma that does not respond to treatment.


Childhood Brain Neuroblastoma

description: A neuroblastoma that arises from the brain during childhood.


Refractory Rhabdoid Tumor

description: Rhabdoid tumor that does not respond to treatment.


name: Stage M1 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2

description: Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hereditary Neuroblastoma

description: Genetic inheritance of neuroblastoma caused by mutations in the ALK or PHOX2B genes.  Familial neuroblastomas have a higher incidence of multiple primary tumors and are diagnosed at an earlier age.


name: Childhood Central Nervous System Ganglioneuroblastoma

description: A central nervous system ganglioneuroblastoma that occurs during childhood.


name: Stage L1 Childhood Neuroblastoma by Toronto Guidelines v2

description: Localized tumor that does not involve any vital structures as defined by the list of IDRFs (i.e., there are no IDRFs) and the tumor must be confined within one body compartment, neck, chest, abdomen, or pelvis. An intraspinal tumor extension that does not fulfill the criteria for an IDRF is consistent with stage L1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Advanced Chordoma

description: A chordoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Central Nervous System Embryonal Tumor, Not Otherwise Specified with Leptomeningeal Spread

description: A central nervous system embryonal tumor, not otherwise specified which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Visual Pathway Medulloepithelioma

description: A very rare, benign or malignant embryonal neoplasm affecting the visual pathway during childhood. It arises from primitive medullary epithelium.


name: Embryonal Tumor with Multilayered Rosettes of the Fourth Ventricle

description: An embryonal tumor with multilayered rosettes that arises from the fourth ventricle.


Stage M4 Medulloblastoma

description: Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Stage M3 Childhood Medulloblastoma by Toronto Guidelines v2

description: Visible metastasis in spine or visible metastasis in cervicomedullary junction. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Atypical Teratoid/Rhabdoid Tumor-TYR

description: Atypical teratoid/rhabdoid tumor characterized by overexpression of melanosomal genes (TYR, TYRP, MITF, and OTX2).


name: Stage M3 Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2


name: Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System

description: A common pediatric extracranial tumor arising from neural crest cells.  It involves the adrenal medulla and the sympathetic nervous system.


name: Adult Supratentorial Embryonal Tumor, Not Otherwise Specified

description: A supratentorial embryonal tumor, not otherwise specified that occurs in adults.


Anaplastic Medulloblastoma

description: A medulloblastoma characterized by marked nuclear pleomorphism, and high mitotic activity.


Paratesticular Wilms Tumor

description: A rare Wilms tumor that arises from the paratesticular structures.


name: Childhood Neuroblastoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood neuroblastoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


Atypical Teratoid/Rhabdoid Tumor-SHH

description: Atypical teratoid/rhabdoid tumor characterized by overexpression of genes in the sonic hedgehog (SHH) pathway (GLI2, BOC, PTCHD2, and MYCN).


Prostate Wilms Tumor

description: A rare Wilms tumor affecting the prostate gland.


name: Childhood Atypical Teratoid/Rhabdoid Tumor

description: An atypical teratoid/rhabdoid tumor occurring in children.


name: Stage M0 Childhood Medulloblastoma by Toronto Guidelines v2

description: No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Localized Childhood Neuroblastoma by Toronto Guidelines v2

description: Localized tumor not involving vital structures and confined to one body compartment. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


description: An intermixed ganglioneuroblastoma that occurs during childhood.


name: Pineoblastoma miRNA Processing Altered 1

description: Pineoblastoma characterized by alterations in genes involved in miRNA biogenesis (DICER1, DROSHA, and DGCR8). It may manifest as a sporadic tumor or part of DICER1 syndrome. It affects children.


Localized Resectable Neuroblastoma

description: Neuroblastoma that is confined to a specific site and is amenable to surgical removal.


name: Refractory Peripheral Primitive Neuroectodermal Tumor

description: Peripheral primitive neuroectodermal tumor that does not respond to treatment.


Recurrent Rhabdoid Tumor

description: The reemergence of rhabdoid tumor after a period of remission.


Thyroblastoma

description: A high-grade, rapidly growing malignant embryonal neoplasm that arises from the thyroid gland. It is characterized by the presence of primitive follicular-like structures surrounded by primitive small cells and primitive spindle cell mesenchymal stroma. It is associated with DICER1 gene mutations. The prognosis is poor.


Extra-osseous Ewing's sarcoma recurrent

description: Reemergence of extraskeletal Ewing sarcoma after a period of remission.


name: Peripheral neuroepithelioma of bone metastatic

description: A small round cell tumor of the bone with neural differentiation that has spread from its original site of growth to another anatomic site.


Unresectable Ewing Sarcoma

description: A Ewing sarcoma which is not amenable to surgical resection.


name: Stage M4 Embryonal Tumor with Multilayered Rosettes

description: Metastasis outside the cerebrospinal axis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Central Nervous System Embryonal Neoplasm

description: A malignant neoplasm of embryonal origin, arising from the central nervous system.  It usually affects children.  Representative examples include ependymoblastoma, medulloblastoma, and atypical teratoid/rhabdoid tumor.


Locally Advanced Ewing Sarcoma

description: Ewing sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Locally Advanced Olfactory Neuroblastoma

description: Olfactory neuroblastoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Childhood Medulloblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood medulloblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Stage M1 Pineoblastoma

description: Microscopic tumor cells are detected in the cerebrospinal fluid. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


Sellar Dedifferentiated Chordoma

description: A dedifferentiated chordoma that arises from the sellar region.


name: Stage M2 Atypical Teratoid/Rhabdoid Tumor

description: Gross nodular seeding is detected in the cerebellar/cerebral subarachnoid space or in the third or lateral ventricles. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Stage M0 Atypical Teratoid/Rhabdoid Tumor

description: No evidence of subarachnoid or hematogenous metastasis. (Chang CH, Housepian EM, Herbert C. Radiology, 1969; 93(6):1351-9.)


name: Recurrent Childhood Central Nervous System Embryonal Neoplasm

description: The reemergence of childhood central nervous system embryonal neoplasm after a period of remission.


Resectable Neuroblastoma

description: Neuroblastoma that is amenable to surgical resection.


Childhood Brain Ganglioneuroblastoma

description: A ganglioneuroblastoma that arises from the brain and occurs during childhood.


name: Stage L2 Childhood Neuroblastoma by Toronto Guidelines v2

description: Locoregional tumor with one or more IDRFs. The tumor may be ipsilateral contiguous within body compartments (i.e., a left-sided abdominal tumor with left-sided lung, bone or pleura involvement should be considered stage L2). However, a clearly left-sided abdominal tumor with right-sided lung, bone or pleura (or vice-versa) involvement is defined as metastatic disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Neuroblastoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood neuroblastoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


High Risk Neuroblastoma

description: Neuroblastoma usually presenting with metastatic disease and MYCN gene amplifications.


name: embryonal tumor with multilayered rosettes

description: A central nervous system embryonal tumor characterized by the presence of multilayered rosette formation and typically the presence of amplification of the C19MC region on chromosome 19 (19q13.42) or rarely a DICER1 mutation.


name: Peripheral neuroepithelioma of bone recurrent

description: The reemergence of peripheral primitive neuroectodermal tumor of the bone after a period of remission.


Cribriform Neuroepithelial Tumor

description: A very rare, nonrhabdoid, intraventricular tumor with relatively favorable prognosis.  It is characterized by the presence of neuroepithelial cells forming cribriform patterns, trabeculae, epithelial membrane antigen immunopositivity on epithelial surfaces, and loss of nuclear INI 1 expression.


Sellar Chordoma

description: A chordoma that arises from the sellar region.


description: The reemergence of medulloblastoma, WNT-activated after a period of remission.


Stage 3 Neuroblastoma

description: Unresectable unilateral tumor infiltrating across the midline, with or without regional lymph node involvement; or localized unilateral tumor with contralateral regional lymph node involvement; or midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement. The midline is defined as the vertebral column. Tumors originating on one side and crossing the midline must infiltrate to or beyond the opposite side of the vertebral column. (cancer.gov)


name: Refractory Atypical Teratoid/Rhabdoid Tumor

description: An atypical teratoid/rhabdoid tumor that does not respond to treatment.


Stage 4S neuroblastoma

description: Localized primary tumor, as defined for stage 1, 2A, or 2B, with dissemination limited to skin, liver, and/or bone marrow (limited to infants younger than 1 year). Marrow involvement should be minimal (i.e., <10% of total nucleated cells identified as malignant by bone biopsy or by bone marrow aspirate). More extensive bone marrow involvement would be considered stage 4 disease. The results of the MIBG scan, if performed, should be negative for disease in the bone marrow. (cancer.gov)


name: Metastatic Childhood Neuroblastoma by Toronto Guidelines v2

description: Distant metastatic disease (except stage MS). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Central Nervous System Embryonal Tumor by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood central nervous system embryonal tumor according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Localized Childhood Medulloblastoma by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Medulloblastoma with Leptomeningeal Spread

description: A medulloblastoma which has spread from its original site to the leptomeninges surrounding the brain and spinal cord.


Unresectable Rhabdoid Tumor

description: A rhabdoid tumor that is not amenable to surgical resection.