Stage IV Renal Pelvis Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat. N0: No regional lymph node metastasis. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm in greatest dimension; or multiple lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Metastatic Chromophobe Renal Cell Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Chromophobe renal cell carcinoma that has spread from the original site of growth to another anatomic site.


Stage III Renal Pelvis Cancer AJCC v7

description: Stage III includes: T3, N0, M0.  T3: Tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  N0: No lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Eosinophilic Solid and Cystic Renal Cell Carcinoma

description: A renal cell carcinoma associated with biallelic somatic mutations in the TSC1 or TSC2 genes and characterized by the presence of neoplastic polygonal cells with abundant eosinophilic cytoplasm and cystic changes.


name: Unresectable Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that is not amenable to surgical resection.


ALK-Rearranged Renal Cell Carcinoma

description: An extremely rare renal cell carcinoma characterized by the presence of chromosomal translocations involving the chromosome 2p23 breakpoint that result in gene fusions between the anaplastic lymphoma kinase gene (ALK) and various gene partners.


Metastatic Kidney Medullary Carcinoma

description: Kidney medullary carcinoma that has spread to another anatomical site.


name: Chromophobe Renal Cell Carcinoma Associated with Birt-Hogg-Dube Syndrome

description: Chromophobe renal cell carcinoma that develops in a patient with Birt-Hogg-Dube syndrome.


name: Refractory Clear Cell Renal Cell Carcinoma

description: Clear cell renal cell carcinoma that is resistant to treatment.


name: Metastatic Sarcomatoid Renal Cell Carcinoma

description: Sarcomatoid renal cell carcinoma that has spread to another anatomical site.


Childhood Kidney Carcinoma

description: A kidney carcinoma that occurs during childhood.


Stage IV Renal Cell Cancer AJCC v8

description: Stage IV includes: (T4, Any N, M0); (Any T, Any N, M1). T4: Tumor invading beyond Gerota's fascia (including contiguous extension into the ipsilateral adrenal gland). M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 4 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by extreme nuclear pleomorphism and/or sarcomatoid and/or rhabdoid differentiation and/or tumor giant cells. (WHO, 1982 /ISUP 2014)


name: Recurrent Chromophobe Renal Cell Carcinoma

description: The reemergence of chromophobe renal cell carcinoma after a period of remission.


name: Recurrent Renal Pelvis Urothelial Carcinoma

description: The reemergence of renal pelvis urothelial carcinoma after a period of remission.


Unresectable Kidney Carcinoma

description: A kidney carcinoma that is not amenable to surgical resection.


name: Locally Advanced Kidney Medullary Carcinoma

description: Kidney medullary carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: BAP1-Mutant Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma that is associated with a mutation in BAP1 gene. These tumors are typically high grade and associated with poor outcome.


name: Metastatic Renal Pelvis Urothelial Carcinoma

description: Renal pelvis urothelial carcinoma that has spread to another anatomical site.


name: Childhood Eosinophilic Solid and Cystic Renal Cell Carcinoma

description: An eosinophilic solid and cystic renal cell carcinoma that occurs during childhood.


name: Locally Advanced Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that has spread to nearby tissues or lymph nodes.


name: Locally Advanced Papillary Renal Cell Carcinoma

description: Papillary renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Renal Cell Carcinoma Associated with t(X;17)(p11.2;q25)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;q25) resulting in fusion of the ASPL and TFE3 genes.


name: Clear-cell metastatic renal cell carcinoma

description: A clear cell renal cell carcinoma that has spread from its original site of growth to other anatomic sites.


Stage II Renal Pelvis Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage II Renal Cell Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor measuring more than 7 cm in greatest dimension, limited to the kidney. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Kidney Carcinoma

description: The reemergence of kidney carcinoma after a period of remission.


name: Renal Pelvis Urothelial Carcinoma, High Grade

description: Renal pelvis urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


name: Locally Advanced Clear Cell Renal Cell Carcinoma

description: Clear cell renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Renal Cell Carcinoma Associated with inv(X)(p11;q12)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the inv(X)(p11;q12) resulting in fusion of the NONO (p54nrb) and TFE3 genes.


Metastatic Kidney Carcinoma

description: A carcinoma that arises from the kidney and has metastasized to another anatomic site.


name: Unresectable Sarcomatoid Renal Cell Carcinoma

description: A sarcomatoid renal cell carcinoma that is not amenable to surgical resection.


name: Unresectable Chromophobe Renal Cell Carcinoma

description: A chromophobe renal cell carcinoma that is not amenable to surgical resection.


name: Renal Cell Carcinoma, Not Otherwise Specified

description: A renal cell carcinoma that cannot be classified into one of the established subtypes of renal cell carcinoma.


name: Non-Hereditary Clear Cell Renal Cell Carcinoma

description: The most common type of renal cell carcinoma, characterized by a loss of genetic material of the short arm of chromosome 3.  The most common symptom at the time of diagnosis is hematuria.  The tumor has a golden-yellow color because of the abundance of intracytoplasmic lipid.  This is a clinically aggressive type of renal cell carcinoma.  The tumor usually metastasizes to unusual sites and late metastasis is common.


Stage II Renal Cell Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Lesions have been divided into T2a and T2b.  T2a is defined as tumor more than 7 cm but less than or equal to 10 cm in greatest dimension, limited to the kidney.  T2b is defined as tumor greater than 10 cm, limited to the kidney.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations

description: A renal cell carcinoma with constitutional chromosome 3 translocations.


name: Locally Advanced Chromophobe Renal Cell Carcinoma

description: Chromophobe renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Refractory Renal Pelvis Urothelial Carcinoma

description: Renal pelvis urothelial carcinoma that is resistant to treatment.


name: Metastatic Unclassified Renal Cell Carcinoma

description: A renal cell carcinoma, not otherwise specified, that has spread from the original site of growth to another anatomic site.


Unresectable Kidney Medullary Carcinoma

description: A kidney medullary carcinoma that is not amenable to surgical resection.


Non-Clear Cell Renal Cell Carcinoma

description: A group of renal cell carcinomas characterized by the absence of lipid-containing clear adenocarcinoma cells. This category includes the following morphological subtypes: papillary renal cell carcinoma; sarcomatoid renal cell carcinoma; chromophobe renal cell carcinoma; tubulocystic renal cell carcinoma; and eosinophilic solid and cystic renal cell carcinoma.


name: Locally Recurrent Clear Cell Renal Cell Carcinoma

description: The reemergence of clear cell renal cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Renal Cell Cancer by AJCC v8 Stage

description: A term that refers to the staging of kidney cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas arising in the kidney. It does not apply to urothelial carcinomas (are staged according to the classification for renal pelvis and ureter), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs), and Wilms tumor (no AJCC staging system). (from AJCC 8th Ed.)


name: Childhood SMARCB1-Deficient Kidney Medullary Carcinoma

description: A SMARCB1-deficient kidney medullary carcinoma that occurs during childhood.


Metastatic Renal Pelvis Carcinoma

description: Renal pelvis carcinoma that has spread from the original site of growth to other anatomic sites.


name: Metastatic Papillary Renal Cell Carcinoma

description: A papillary renal cell carcinoma that has spread from the original site of growth to another anatomic site.


name: Early Stage Clear Cell Renal Cell Carcinoma

description: A stage term referring to clear cell renal cell carcinoma that presents as a small tumor and is confined to the kidney.


Recurrent Kidney Medullary Carcinoma

description: The reemergence of kidney medullary carcinoma after a period of remission.


name: Renal Cell Carcinoma Associated with t(X;1)(p11.2;q21)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;q21) resulting in fusion of the PRCC and TFE3 genes.


Renal Pelvis Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal pelvis cancer according to the American Joint Committee on Cancer, 7th edition.


Refractory Kidney Medullary Carcinoma

description: A kidney medullary carcinoma that does not respond to treatment.


Refractory Renal Cell Carcinoma

description: Renal cell carcinoma that does not respond to treatment.


Grade 3 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 100 magnification. (WHO 1982 /ISUP 2014)


Locally Advanced Renal Cell Carcinoma

description: Renal cell carcinoma that has spread to nearby tissues or lymph nodes.


Stage III Renal Pelvis Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into peripelvic fat or into the renal parenchyma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Transplant-Related Renal Cell Carcinoma

description: A renal cell carcinoma that arises in a patient with a history of organ transplantation.


ELOC-Mutated Renal Cell Carcinoma

description: A renal cell carcinoma characterized by the presence of mutations in the ELOC (TCEB1)  gene at 8q21.11.


name: Renal Cell Carcinoma Associated with t(X;1)(p11.2;p34)

description: A renal cell carcinoma with papillary architecture comprised of clear cells. It is characterized by the t(X;1)(p11.2;p34) resulting in fusion of the PSF and TFE3 genes.


Renal Cell Cancer by AJCC v6 Stage

description: A term that refers to the staging of renal cell cancer according to the American Joint Committee on Cancer, 6th edition.


Kidney Carcinoma Molecular Subtypes

description: A term that refers to the classification of kidney carcinomas according to their molecular characteristics.


name: Succinate Dehydrogenase-Deficient Renal Cell Carcinoma

description: A very rare renal cell carcinoma that usually affects young adults. It is characterized by mutations in one of the four subunits of the SDH complex (SDHA, SDHB, SDHC, or SDHD gene). Most frequently, the mutations occur in the SDHB subunit. It has a relatively good prognosis.


Unresectable Renal Cell Carcinoma

description: A renal cell carcinoma that is not amenable to surgical resection.


Stage IV Renal Cell Cancer AJCC v7

description: Stage IV includes: (T4, Any N, M0); (Any T, Any N, M1). T4: Tumor invades beyond Gerota's fascia (including contiguous extension into the ipsilateral adrenal gland).  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


Grade 2 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by nucleoli conspicuous and eosinophilic at x 400 magnification, and visible but not prominent at x 100 magnification. (WHO 1982 /ISUP 2014)


Grade 1 Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma characterized by absent or inconspicuous and basophilic nucleoli at x 400 magnification. (WHO 1982 /ISUP 2014)


Locally Advanced Renal Pelvis Carcinoma

description: Renal pelvis carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Locally Advanced Kidney Carcinoma

description: Kidney carcinoma that has spread to nearby tissues or lymph nodes.


Renal cell carcinoma recurrent

description: A reemergence of renal cell carcinoma after a period of remission.


Localized Renal Cell Carcinoma

description: A renal cell carcinoma that is mainly confined to the kidney with or without involvement of perinephric tissues and without evidence of spread to other organs.


Kidney Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Stage IV Renal Pelvis Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


name: Locally Advanced Sarcomatoid Renal Cell Carcinoma

description: Sarcomatoid renal cell carcinoma that has spread to nearby tissues or lymph nodes.


name: Recurrent Clear Cell Renal Cell Carcinoma

description: The reemergence of clear cell renal cell carcinoma after a period of remission.


name: Unresectable Clear Cell Renal Cell Carcinoma

description: A clear cell renal cell carcinoma that is not amenable to surgical resection.


Stage III Renal Cell Cancer AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0). T1: Tumor measuring 7 cm or less in greatest dimension, limited to the kidney. T2: Tumor measuring more than 7 cm in greatest dimension, limited to the kidney. T3: Tumor extending into major veins or perinephric tissues, but not into the ipsilateral adrenal gland and not beyond Gerota's fascia. N0: No regional lymph node metastasis. N1: Metastasis in regional lymph node(s). M0: No distant metastasis. (AJCC 8th ed.)


Renal Cell Cancer by AJCC v7 Stage

description: A term that refers to the staging of renal cell cancer according to the American Joint Committee on Cancer, 7th edition.


Stage I Renal Pelvis Cancer AJCC v7

description: Stage I includes: T1, M0, M0.  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Childhood ALK-Rearranged Renal Cell Carcinoma

description: An ALK-rearranged renal cell carcinoma that occurs during childhood.


Refractory Kidney Carcinoma

description: Kidney carcinoma that is resistant to treatment.


Grade 1 Infantile Vomiting, AE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An adverse event in a newborn characterized by an increase in vomiting over baseline, self limiting.


Infantile Vomiting, AE

description: An adverse event in a newborn characterized by expulsion of the contents of the stomach through the mouth.


Grade 2 Infantile Vomiting, AE

description: An adverse event in a newborn characterized by a persistent increase in vomiting over baseline; no dehydration; minor changes in feeding support indicated.


Grade 5 Infantile Vomiting, AE

description: A vomiting adverse event in a newborn which results in death.


Grade 4 Infantile Vomiting, AE

description: A vomiting adverse event in a newborn characterized by life-threatening consequences (e. g. severe dehydration).


Grade 3 Infantile Vomiting, AE

description: An adverse event in a newborn characterized by a persistent increase in vomiting over baseline; signs of dehydration; major changes in feeding support indicated (e.g. change to total parenteral nutrition (TPN) or gavage).


name: Grade 1 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 5 Bladder Perforation, CTCAE

description: Death


Grade 1 Allergic Rhinitis, CTCAE

description: Mild symptoms; intervention not indicated


Allergic Rhinitis, CTCAE

description: A disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching.


Grade 2 Allergic Rhinitis, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Invasive Adenocarcinoma in Adenomatous Polyp

description: An invasive adenocarcinoma that arises in an adenomatous polyp.


Post-Procedural Pain

description: Pain experienced after a medical intervention through the time expected for associated acute effects to abate.


Skullcap Lesion

description: A neoplastic, inflammatory, or vascular process in the roof of the skull.


name: Grade 4 CNS Necrosis and Cystic Progression, CTCAE


name: Grade 1 Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


name: Grade 2 Radiation Recall Reaction (Dermatologic), CTCAE

description: Moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema


Elevated Catecholamine Metabolites

description: A finding indicating elevated concentrations of catecholamine metabolites in a biological sample.


Grade 4 Bronchospasm, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Grade 2 Lymphedema, CTCAE

description: Marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL


name: Grade 1 Cranial Nerve I Intra-Operative Injury, CTCAE


name: Grade 4 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Soft Tissue Infection, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Gallbladder Intracholecystic Papillary Neoplasm, High Grade

description: An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of severe epithelial atypia.


Wheezing, CTCAE

description: A disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways.


Gestational diabetes mellitus class A1

description: Carbohydrate intolerance first diagnosed during pregnancy. Diagnosis from abnormal oral glucose tolerance test (OGTT) but normal glucose levels when fasting and two hours post-prandial. Euglycemia achieved with diet and/or exercise.


name: Grade 2 Upper Airway Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Biliary Tract Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Carcinomatosis of peritoneal cavity

description: A condition in which a carcinoma has spread extensively throughout the peritoneum.


name: Childhood Acute Myeloid Leukemia with Maturation

description: An acute myeloid leukemia with maturation occurring in children.


name: Grade 3 Duodenum Intra-Operative Injury, CTCAE


name: Grade 1 Right Ventricular Dysfunction, CTCAE

description: Asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities


Type B Lymphomatoid Papulosis

description: A variant of lymphomatoid papulosis characterized by an epidermotropic infiltrate composed of small atypical cerebriform-like lymphocytes.


name: Grade 2 Social Circumstances - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Diffuse Pediatric-Type High Grade Glioma MYCN

description: An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by the expression of MYCN molecular signature.


Urethral Infection, CTCAE

description: A disorder characterized by an infectious process involving the urethra.


Welding Exposure

description: Environmental, occupational, or consumer-based exposure to vaporized materials or dusts created during the welding process.


Retropharyngeal Abscess

description: An abscess that develops in the soft tissues behind the posterior pharyngeal wall.


Factor IX Inactivation

description: Presence of inactivating antibodies to factor IX in the blood.


Benign neoplasm of adnexa of skin

description: A neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include cylindroma, hidrocystoma, hidradenoma, and sebaceoma.


Grade 1 Sore Throat, CTCAE

description: Mild pain


Adult Grade I Meningioma

description: A grade I meningioma that occurs during adulthood.


name: Recurrent Lymphocyte-Rich Classic Hodgkin Lymphoma

description: The reemergence of lymphocyte-rich classic Hodgkin lymphoma after a period of remission.


Grade 4 Hypoxia, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Decreased Expression

description: An indication that the expression of a gene, transcript or protein is lower than a previous value or a normal range of values.


Torturing Pain

description: A sensation of having discomfort or distress inflicted upon an individual.


name: High Grade Appendix Mucinous Adenocarcinoma

description: A mucinous adenocarcinoma that arises from the appendix. The malignant cells are numerous and exhibit high grade dysplasia.  It may be associated with pseudomyxoma peritonei, but unlike the low grade mucinous neoplasm, it invades other organs and metastasizes to distant anatomic sites.


Recurrent Malignant Abdominal Neoplasm

description: The reemergence of a malignant abdominal neoplasm after a period of remission.


name: Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Vasculitis, CTCAE

description: Severe symptoms, medical intervention indicated (e.g., steroids)


Neuralgia, CTCAE

description: A disorder characterized by intense painful sensation along a nerve or group of nerves.


Gallbladder Necrosis, CTCAE 5.0

description: A disorder characterized by a necrotic process occurring in the gallbladder.


Grade 4 Mitral Valve Disease, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)


name: Grade 4 Radiation Excluding Chemoradiation, CTCAE


Adult Classical Hodgkin Lymphoma

description: Classic Hodgkin lymphoma that occurs in adults.


name: Childhood Acute Lymphoblastic Leukemia CNS 1 Toronto Guidelines v2

description: No clinical signs of CNS involvement and no blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Elevated LIF

description: A finding indicating elevated concentrations of LIF in a sample.


Adenomatous hyperplasia

description: Proliferation of the glandular epithelial cells.


Stage IIB Appendix Carcinoma AJCC v8

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Renal Hemorrhage, CTCAE

description: Analgesics and hematocrit monitoring indicated


Posterior Subcapsular Cataract Grade 4

description: A stage of posterior subcapsular cataract characterized by greater than 50% of the posterior capsule obscured by opacity. (Modified LOCS II)


Grade 4 Gastrointestinal Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Stage IIA Gestational Trophoblastic Tumor AJCC v7

description: Stage IIA includes: T2, M0, Risk factors: low risk.  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Substance Adverse Event

description: An unexpected or dangerous reaction to a substance (e.g., food, environmental agent). (ACC)


Grade 2 Rectal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 2 Capillary Leak Syndrome, CTCAE

description: Symptomatic; medical intervention indicated


Colonic Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of the intestinal contents in the colon.


Grade 2 Arachnoiditis, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Retroperitoneum injury with open wound into cavity

description: Trauma to  retroperitoneal tissue associated with a wound that extends into the retroperitoneal space.


Adult Giant Cell Glioblastoma

description: A giant cell glioblastoma occurring in adults.


name: Oral Cavity NOS Intra-Operative Injury, CTCAE


name: Grade 3 Intraoperative Musculoskeletal Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Moderate Cardiac Valve Regurgitation

description: Evidence of moderate retrograde blood flow through the valve(s) of the heart. (ACC)


AV Fistula Maturation Failure

description: Inadequate development of an arteriovenous fistula within three months of creation.


name: Grade 4 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Injection Site Reaction or Extravasation Changes, CTCAE


Myelodysplastic Syndrome, CTCAE

description: A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.


name: Grade 4 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Anal Adenocarcinoma

description: The reemergence of anal adenocarcinoma after a period of remission.


Grade 2 Laryngeal Inflammation, CTCAE

description: Moderate sore throat; analgesics indicated


Drug Induced Thrombocytopenia

description: Thrombocytopenia caused by ingested or injected drugs. It may be the result of decreased platelet production due to bone marrow suppression or increased rate of platelet destruction.


Metastatic malignant neoplasm to vagina

description: A malignant neoplasm that has spread to the vagina from another anatomic site.


name: Ampulla of Vater Cancer by AJCC v8 Stage

description: A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 8th edition. This staging system does not apply to well-differentiated neuroendocrine (carcinoid) tumors but does apply to high-grade neuroendocrine carcinomas, such as small cell carcinoma and large cell neuroendocrine carcinoma. (from AJCC 8th Ed.)


name: Grade 1 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Grade 1 Hepatic Pain, CTCAE

description: Mild pain


name: Biliary Tree NOS Intra-Operative Injury, CTCAE


name: Recurrent Malignant Spermatic Cord Neoplasm

description: The reemergence of a malignant spermatic cord neoplasm after a period of remission.


name: Grade 1 Urinary Frequency or Urgency, CTCAE


name: Malignant Non-Hodgkin's Lymphoma, Small Cleaved Cell


Grade 3 Eyelid Function Disorder, CTCAE

description: Limiting self care ADL; operative intervention indicated


Invasive Cutaneous Melanoma

description: A melanoma of the skin that is not confined to the dermal-epidermal junction, and has infiltrated the dermis.


name: Grade 3 Hypoglossal Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 2 Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Parotid Gland Intra-Operative Injury, CTCAE


Non-Hematologic Toxicity

description: A toxicity that impairs or damages other than the hematologic system.


Mediastinal Diseases

description: A non-neoplastic or neoplastic disorder that affects the structures of the mediastinum.  Representative examples include mediastinitis, mediastinal lipoma, mediastinal schwannoma, thymoma, and mediastinal lymphoma.


name: FIGO Stage I Gestational Trophoblastic Tumor

description: Lesion is confined to the uterus.


Sweating fever

description: A febrile response accompanied by diaphoresis.


Anticipated Adverse Event

description: An adverse event that is reasonably expected and/or listed in the clinical protocol or other study-related document.


Recurrent Gliomatosis Cerebri

description: The reemergence of gliomatosis cerebri after a period of remission.


Lacrimal Gland Oncocytoma

description: A benign epithelial neoplasm that arises from the lacrimal gland. It is characterized by the presence of oncocytic cells with abundant eosinophilic and granular cytoplasm.


name: Grade 5 Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Fallopian Tube Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the fallopian tube.  Representative examples include acute and chronic salpingitis, salpingitis isthmica nodosa, and endometriosis.


name: Grade 1 Laryngeal Nerve Dysfunction, CTCAE


name: Grade 5 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Prosthetic valve endocarditis

description: Endocarditis occurring on parts of a valve prosthesis or a reconstructed heart valve; it can be classified into early and late prosthetic valve endocarditis.


name: Grade 1 Cranial Nerve X Neuropathy, CTCAE


name: Primary cutaneous CD4 positive small/medium T-cell lymphoproliferative disorder

description: A primary cutaneous T-cell lymphoproliferative disorder.  It usually presents with a solitary plaque or tumor on the face, neck, or upper trunk.  Morphologically, it is composed of small to medium-sized CD4-positive, CD8-negative, and CD30-negative pleomorphic T-lymphocytes.  A small number of large pleomorphic T-lymphocytes may also be present.  The lymphocytic infiltrate is dermal.  Focal epidermotropism and subcutaneous involvement may be present.  The clinical behavior is almost always indolent and most patients present with localized disease.


name: Infection by methicillin sensitive Staphylococcus aureus

description: A bacterial infection that is caused by Staphylococcus aureus that is susceptible to methicillin.


Refractory Leukemia

description: Leukemia that is resistant to treatment.


name: Grade 5 Pulmonary Fibrosis Radiographic Changes, CTCAE


name: Grade 4 Bronchospasm and Wheezing, CTCAE


name: Locally Advanced Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Childhood Diffuse Astrocytoma

description: A diffuse astrocytoma that occurs during childhood.


Grade 5 Pharyngeal Mucositis, CTCAE

description: Death


Grade 3 Dyspareunia, CTCAE

description: Severe discomfort or pain associated with vaginal penetration; discomfort or pain unrelieved by vaginal lubricants or estrogen


Stage IIIC Vulvar Cancer AJCC v8

description: Stage IIIC includes: T1-T2, N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Low Grade Conjunctival Melanocytic Intraepithelial Lesion

description: Conjunctival melanocytic intraepithelial lesion characterized by the presence of mild atypia.


name: MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1C

description: A sub-type of limb-girdle muscular dystrophy caused by mutation(s) in the CAV3 gene, encoding caveolin-3.


name: Grade 1 Colon or Cecum or Appendix Fistula, CTCAE


name: Intraoperative Gastrointestinal Injury, CTCAE

description: A finding of damage to the gastrointestinal system during a surgical procedure.


Lymphocyte Count Decreased, CTCAE

description: A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.


name: congenital malformation syndromes due to known exogenous causes

description: A syndrome characterized by the presence of structural malformations that are present at birth and can be attributed to an exogenous cause.


Nagging Pain

description: A sensation of discomfort or distress that is persistent and continuous.


Grade 2 Fecal Incontinence, CTCAE

description: Daily use of pads required


Grade 2 Duodenal Perforation, CTCAE

description: Invasive intervention not indicated


Grade 1 Belching, CTCAE

description: Increase from baseline


name: Grade 3 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Infantile Apnea, AE

description: An adverse event in a newborn characterized by cessation of air flow.


Adenocarcinoma of Unknown Primary

description: An adenocarcinoma which has metastasized from an unknown primary anatomic site.


name: Low Grade Prostatic Intraepithelial Neoplasia

description: Prostatic intraepithelial neoplasia characterized by the proliferation of secretory cells with irregular spacing in the ducts and acini.  Although some proliferating epithelial cells may contain prominent nucleoli, the cytologic atypia and architectural growth patterns that are seen in the high grade prostatic intraepithelial neoplasia are absent.  The presence of low grade prostatic intraepithelial neoplasia in needle biopsy is not a risk factor for the subsequent detection of carcinoma on repeat biopsy.


name: Stage IV Ampulla of Vater Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Recurrent WHO Grade 2 Glioma

description: The reemergence of WHO grade 2 glioma after a period of remission.


Grade 3 Colonic Perforation, CTCAE

description: Invasive intervention indicated


name: Grade 2 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Alkalosis, CTCAE

description: A disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.


Hypercholesterolemia

description: A laboratory test result indicating an increased amount of cholesterol in the blood.


Recurrent Glioma

description: The reemergence of a glioma after a period of remission.


name: Grade 1 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


name: Grade 1 Face NOS Intra-Operative Injury, CTCAE


name: Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1

description: An acute myeloid leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 occurring in adults.


name: Grade 2 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Increased Corpora Lutea

description: An increase in the number of corpora lutea within the ovary.


name: Pathologic Stage IIB Merkel Cell Carcinoma AJCC v8

description: Stage IIB includes: T4, N0, M0. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Skin Induration, CTCAE

description: A disorder characterized by an area of hardness in the skin.


name: Grade 4 Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Radiation Recall Reaction (Dermatologic), CTCAE

description: Death


name: Paratesticular Well Differentiated Papillary Mesothelial Tumor

description: A rare, indolent, usually solitary mesothelial neoplasm that arises from the tunica vaginalis. It is characterized by the presence of a papillary architecture in which the papillae are lined by cuboidal mesothelial cells. Mitotic figures are usually absent. Stromal invasion is absent or minimal. It usually manifests with a hydrocele and less frequently scrotal mass.


Stage IIIB Cervical Cancer AJCC v9

description: Stage IIIB includes: T3b, N0, M0. T3b: Tumor extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Bone Epithelioid Hemangioendothelioma

description: A low-grade malignant blood vessel neoplasm arising from the bone.  It is characterized by the presence of epithelioid endothelial cells.  The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.


name: Grade 2 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Bladder Cancer by AJCC v8 Stage

description: A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas arising in the bladder. The typical carcinoma of the bladder is urothelial carcinoma. These carcinomas may include other histologic elements, including adenocarcinoma, squamous cell carcinoma, and small cell neuroendocrine carcinoma, but should be classified as urothelial unless the cancer is composed entirely of the alternative histology. All histologic cell types that are derived primarily from the urinary bladder epithelium should follow this staging system. It does not apply to prostatic urothelial carcinomas (are staged according to the classification for urethra), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


name: Advanced Gastric Large Cell Neuroendocrine Carcinoma

description: A gastric large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 4 Pleural Effusion, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


name: Type IV Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the right and left pulmonary arteries drain into different sites.


name: Refractory Endometrial Mucinous Adenocarcinoma

description: Endometrial mucinous adenocarcinoma that is resistant to treatment.


Endocarditis Infective, CTCAE

description: A disorder characterized by an infectious process involving the endocardial layer of the heart.


name: Grade 5 Atrioventricular Block Complete, CTCAE

description: Death


Adenocarcinoma of the prostate stage I

description: Stage I includes: (T1a-c, N0, M0, PSA less than 10, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 10, Gleason equal or less than 6); (T1-2a, N0, M0, PSA X, Gleason X).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less. cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason X: Gleason score cannot be processed.  (AJCC 7th ed.)


name: Grade 1 Pelvic Floor Muscle Weakness, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Urinary Retention, CTCAE

description: Placement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated


Stage IA Bone Cancer AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Grade 3 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


lymphomatoid papulosis, type A

description: A variant of lymphomatoid papulosis characterized by the presence of scattered anaplastic large lymphocytes, often resembling Reed-Sternberg cells, admixed with acute and chronic inflammatory cells.


Intra-Abdominal Paraganglioma

description: An extra-adrenal paraganglioma arising from the abdominal cavity.


name: Death Due to Disease Progression Not Associated with More Specific Term NOS, CTCAE


name: Pancreatic Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a pancreatic neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to well-differentiated neuroendocrine tumors arising in the pancreas. Carcinomas of the pancreas, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not staged using this staging system. (from AJCC 8th Ed.)


name: Adult Dysembryoplastic Neuroepithelial Tumor

description: A dysembryoplastic neuroepithelial tumor that occurs during adulthood.


name: Grade 5 Peripheral Arterial Ischemia, CTCAE


Stage III Gallbladder Cancer AJCC v7

description: Stage III includes: IIIA (T3, N0, M0); IIIB (T1-3, N1, M0). T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  T1: Tumor invades lamina propria or muscular layer.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver. N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Non-T Non-B CALLA Negative Adult Acute Lymphoblastic Leukemia

description: Non-T non-B, CALLA negative acute lymphoblastic leukemia that occurs during adulthood.


name: Metastatic Human Papillomavirus-Related Malignant Neoplasm

description: A malignant neoplasm that is associated with human papillomavirus infection and has spread from its original site of growth to another anatomic site.


Grade 4 Retinopathy of Prematurity, AE

description: An adverse event in a newborn characterized by unilateral retinal detachment.


Adult Ependymal Tumor

description: An ependymal tumor of the central nervous system occurring in adults.


Dust Exposure

description: Exposure to any type of airborne particulate matter.


Grade 3 Heart Failure, CTCAE

description: Symptoms at rest or with minimal activity or exertion; hospitalization; new onset of symptoms


Impatent structure

description: A congenital anatomic defect characterised by the absence of a normally present opening in an organ or tissue.


Stage IIIA Appendix Carcinoma AJCC v7

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


P3 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) calyceal dilation and the ureter are the same as those in UTD P2, 2) the renal parenchymal is thinned, has increased echogenicity and/or has decreased corticomedullary differentiation, or 3) the bladder is abnormal (wall thickening, ureterocele, posterior urethral dilation). Cases in which there are parenchymal abnormalities but the APRPD is less than 15 mm, are classified as UTD P3. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Primary Intraosseous Squamous Cell Carcinoma-Solid Type

description: A non-keratinizing or keratinizing squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, infiltration of the marrow spaces, and osseous resorption.


Tumor Hemorrhage, CTCAE

description: A disorder characterized by bleeding in a tumor.


Ureter Urothelial Carcinoma, High Grade

description: Ureter urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


name: Stage IIIC2 Uterine Corpus Cancer AJCC v8

description: Stage IIIC2 includes: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Grade 2 Sleep Apnea, CTCAE

description: Moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL


Grade 4 Cranial Nerve Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Necrotizing Enterocolitis, AE

description: An adverse event in newborns characterized by extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis in the intestines .


Stage II Childhood Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Grade 3 Bronchial Obstruction, CTCAE

description: Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)


name: Grade 1 Cranial Nerve II Intra-Operative Injury, CTCAE


Disease Progression, CTCAE

description: Death due to disease progression that cannot be attributed to a CTCAE term associated with Grade 5.


Grade 4 Ileal Obstruction, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Testicular Sex Cord-Gonadal Stromal Tumor, Incompletely Differentiated

description: A sex cord-stromal tumor of the testis in which the neoplastic cells do not show specific differentiation.


name: Refractory Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that is resistant to treatment.


Subgaleal haematoma

description: A collection of blood between the scalp and the skull periosteum.


Naso-palatine duct cyst

description: A non-odontogenic cyst of developmental origin that arises in the midline of the anterior maxilla. It is found exclusively in the midline of the anterior hard palate. (WHO 2017)


Absent Adverse Event

description: The absence of adverse events or within normal limits or values.


name: Grade 5 Bronchospasm and Wheezing, CTCAE


Grade 4 Pharyngeal Stenosis, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


name: Grade 3 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant lymphoma, diffuse

description: An antiquated term referring to non-Hodgkin lymphomas with a diffuse architectural pattern.


Neonatal Bradyarrhythmia, AE

description: An adverse event in a newborn characterized by non-sinus rhythm with an abnormally low heart rate for age.


name: Grade 5 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Retinopathy of Prematurity with Plus Disease

description: A stage of retinopathy of prematurity characterized by the presence of the following in at least two quadrants around the optic nerve: dilation and tortuosity of major retinal vasculature as a result of increased blood flow.


name: Grade 2 Sinus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Fallopian Tube Perforation, CTCAE 5.0

description: A disorder characterized by a rupture of the fallopian tube wall.


name: Ampulla of Vater Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

description: A rare variant of undifferentiated carcinoma that arises from the ampulla of Vater. It is characterized by the presence of non-neoplastic, histiocytic, osteoclast-like multinucleated giant cells.


name: High-Grade Squamous Intraepithelial Lesions

description: A precancerous neoplastic process characterized by the presence of moderate or severe dysplastic cytological changes which extend to the upper part of the squamous epithelium.  Maturation at the surface of the squamous epithelium may or may not be present.  Representative examples include the high grade esophageal squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar intraepithelial neoplasia.


name: Grade 2 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Voice Alteration, CTCAE

description: Mild or intermittent change from normal voice


name: Grade 5 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Solar Radiation-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma arising in a skin site exposed to solar radiation.


name: Locally Advanced Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Sexually Transmitted Chlamydial Disease

description: A chlamydial infection that was sexually transmitted.


Grade 1 Penile Pain, CTCAE

description: Mild pain


name: Recurrent Malignant Genitourinary System Neoplasm

description: The reemergence of a malignant genitourinary system neoplasm after a period of remission.


Intracranial Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the cranium.


Unresectable Gastric Adenocarcinoma

description: A gastric adenocarcinoma that is not amenable to surgical resection.


Grade 4 Urinary Tract Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 2 Weight Gain, CTCAE

description: 10-<20% from baseline


Enteropathogenic E coli Infection

description: A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 9-12 hours and a duration of 12 days. Symptoms may include persistent severe acute diarrhea.


name: Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Biliary Fistula

description: An abnormal communication between the bile ducts and another organ or cavity.


Spindle Cell/Pleomorphic Lipoma

description: A benign lipomatous neoplasm characterized by the presence of an admixture of mature adipose tissue and bland spindle cells.  The pleomorphic variant contains in addition multinucleated giant cells.  It usually arises in the neck and upper trunk in older males.


Grade 5 Urinary Fistula, CTCAE

description: Death


Grade 2 Bronchial Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Stage IIIC1 Uterine Corpus Cancer AJCC v7

description: Stage IIIC1 includes: T1-T3, N1, M0.  T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Grade 2 Dysphasia, CTCAE

description: Moderate receptive or expressive characteristics; impairing ability to communicate spontaneously


name: Grade 2 Pancreatic Duct Intra-Operative Injury, CTCAE


Stage II Skin Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness; Clark level equal or greater than IV; and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


name: Grade 2 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Ureter Intra-Operative Injury, CTCAE


name: Grade 1 Bone Growth Limb Length Discrepancy, CTCAE


Leakage

description: The unintentional discharge of a substance from a container or enclosed space.


Grade 4 Skin Ulceration, CTCAE

description: Any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss


Refractory Pseudomyxoma Peritonei

description: Pseudomyxoma peritonei that is resistant to treatment.


Condylomatous carcinoma

description: A squamous cell carcinoma characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


Advanced Glioblastoma

description: Glioblastoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 4 Recurrent Laryngeal Nerve Palsy, CTCAE


Grade 3 Bladder Perforation, CTCAE

description: Invasive intervention indicated


Corn of toe

description: A thickening of the skin due to friction or pressure which results in the formation of a small, painful, raised bump associated with a conical mass pointing down into the dermis.


name: Grade 3 Non-Infectious Wound Complication, CTCAE


name: Grade 5 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Stomal Ulcer, CTCAE 5.0

description: A disorder characterized by a circumscribed, erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure.


name: Grade 5 Fallopian Tube Perforation, CTCAE

description: Death


name: Grade 1 Bladder Intra-Operative Injury, CTCAE


name: K ATP Channel-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in genes (KNCJ11 and/or ABCC8) encoding either of the 2 proteins (Kir6.2 and/or SUR1) that make up the pancreatic beta cell adenosine triphosphate-sensitive potassium channel, which is crucial for the regulation of glucose-induced insulin secretion.


Grade 1 Prostatic Pain, CTCAE

description: Mild pain


name: Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIIA includes: (T1, N2, M0, Any G); (T2, N1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Jejunal Ulcer, CTCAE

description: Symptomatic; altered GI function


name: Recurrent Malignant Choroid Plexus Neoplasm

description: The reemergence of a malignant choroid plexus neoplasm after a period of remission.


Grade 2 Gingival Pain, CTCAE

description: Moderate pain interfering with oral intake


name: Extrahepatic Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


name: Grade 3 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Regressed germ cell tumor

description: A testicular germ cell tumor that has undergone either partial or complete regression, resulting in the creation of a fibrotic nodule in the testis.


Neuroendocrine Tumor G1

description: A well-differentiated, low-grade epithelial neoplasm with neuroendocrine differentiation. It arises from multiple sites, including the digestive system, lung, and head and neck.


name: Grade 3 Sacral Plexus Intra-Operative Injury, CTCAE


name: AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease

description: Diffuse large B-cell lymphoma arising in HHV8-positive multicentric Castleman disease occurring in HIV-positive patients.


name: Vulvar Squamous Cell Carcinoma with Tumor Giant Cells

description: An aggressive squamous cell carcinoma that arises from the vulva and is characterized by the prominence of malignant giant cells.


Neoplasms, Therapy-Associated

description: The development of a neoplasm in response to medical or surgical treatment, induced by the treatment itself.


name: Grade 4 Trachea Intra-Operative Injury, CTCAE


Prevertebral Abscess

description: An abscess that develops in the tissues within the prevertebral fascia.


Unresectable Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that is not amenable to surgical resection.


name: Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage II Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 3 Acute Kidney Injury, CTCAE

description: Hospitalization indicated


name: Grade 4 Stomach Intra-Operative Injury, CTCAE


name: Grade 3 Stomach Stricture or Stenosis, CTCAE


Non-Severe Aplastic Anemia

description: Aplastic anemia that is characterized by bone marrow cellularity less than 30% and does not meet criteria for severe aplastic anemia.


Acquired Bilateral Cataracts

description: Cataracts in both eyes that result from the aging process, an injury, or as a manifestation of a systemic disorder.


Grade 1 Hypoparathyroidism, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 1 Aorta Artery Intra-Operative Injury, CTCAE


Grade 2 Hypokalemia, CTCAE

description: Symptomatic with <LLN-3.0 mmol/L; intervention indicated


name: Grade 3 Neuroendocrine ADH Secretion Abnormality, CTCAE


Gastric Fistula

description: An abnormal communication between the stomach and another organ or anatomic site.


Diabetes mellitus without complication

description: Diabetes mellitus that does not show any evidence of tissue or organ damage.


name: Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Stage IA Ampulla of Vater Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Pancreatic Fistula, CTCAE

description: Death


name: Elevated Choriogonadotropin Subunit Beta

description: A finding indicating elevated concentrations of human chorionicgonadotropin subunit beta in a sample.


Advanced Sarcoma of the Extremity

description: A sarcoma of the soft tissues or bones of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Appendicitis Perforated, CTCAE

description: Medical intervention indicated; operative intervention indicated


Productive Cough, CTCAE

description: A disorder characterized by expectorated secretions upon coughing.


name: Grade 1 Other Renal or Genitourinary, CTCAE


name: Grade 4 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


Serous Tubal Intraepithelial Carcinoma

description: A non-invasive serous carcinoma arising from the fallopian tube.


Birth Injuries

description: An injury sustained to a neonate during the birthing process.


Age-Related Clonal Hematopoiesis

description: The gradual, clonal expansion of hematopoietic stem and progenitor cells carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. It is associated with an increased risk of developing hematologic cancers.


Secondary Cerebral Hodgkin Lymphoma

description: A Hodgkin lymphoma that has spread to the cerebral hemisphere following the initial presentation in another nodal or extranodal site.


name: Grade 4 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Lesion

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part.


Grade 3 Injury To Carotid Artery, CTCAE

description: Severe symptoms; limiting self care ADL (e.g., transient cerebral ischemia); repair or revision indicated


Borderline Peritoneal Serous Tumor

description: A serous epithelial tumor that arises from the peritoneum and histologically resembles the serous borderline tumors that arise from the ovary.


name: Grade 4 Neonatal Culture Positive Sepsis, AE

description: A culture positive sepsis adverse event in a newborn characterized by life-threatening consequences (e. g. shock, disseminated intravascular coagulation (DIC)); urgent major care change required.


Grade 3 Bronchial Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Pathologic Stage IIC Cutaneous Melanoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Muscle Weakness Right-Sided, CTCAE

description: A disorder characterized by a reduction in the strength of the muscles on the right side of the body.


name: Metastatic malignant neoplasm to urethra

description: A malignant neoplasm that has spread to the urethra from another anatomic site.


name: Grade 2 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Nasal Congestion, CTCAE

description: Associated with bloody nasal discharge or epistaxis


Inflammatory Hepatocellular Adenoma

description: A hepatocellular adenoma that occurs more often in women.  It is characterized by increased levels of inflammation-associated proteins.  It is usually associated with steatosis and obesity.


name: Grade 2 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Elevated Type I Collagen Cross-Linked N-Telopeptide

description: A laboratory test result indicating the presence of an increased level of the bone resorption marker type I collagen cross-linked N-telopeptide (NTx or NTxI) in a biological sample.


Marrow Toxic Injury

description: An injury to the bone marrow resulting from exposure to high levels of ionizing radiation or exposure to other hazardous material.


Non-Obstructed Megaureter

description: A megaureter in which there is no obstruction at the ureterovesical junction.


name: Refractory Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma that is resistant to treatment.


Stage III Uterine Corpus Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Unresectable Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that is not amenable to surgery.


Urinary System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the urinary system. Representative examples include kidney carcinoma and bladder carcinoma.


Recto-Vesico-Vaginal Fistula

description: An abnormal communication between the rectum, bladder, and vagina.


name: Chest Pain Along Right Lower Sternal Border

description: The location of the chest pain is along the right lower border of the sternum.


Grade 3 Laryngeal Mucositis, CTCAE

description: Severe pain; severely altered eating/swallowing; medical intervention indicated


Broad Ligament Serous Adenofibroma

description: A rare serous adenofibroma arising from the broad ligament.


Neck Edema, CTCAE

description: A disorder characterized by swelling due to an accumulation of excessive fluid in the neck.


name: Grade 1 Depressed Level of Consciousness, CTCAE

description: Decreased level of alertness


Acute Respiratory Distress

description: An abrupt onset of signs or symptoms indicating difficulty breathing including alterations in breath sounds and rate, chest retractions and color changes.


Esophageal Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of the contents in the esophagus.


Grade 3 Pleural Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


description: An adenocarcinoma associated with the presence of human papillomavirus infection.


name: Non-Myocardial Visceral Arterial Ischemia, CTCAE


Refractory T-Cell and NK-Cell Neoplasm

description: T-cell and NK-cell neoplasm that is resistant to treatment.


name: Grade 4 Urinary Conduit Intra-Operative Injury, CTCAE


Grade 2 Wound Dehiscence, CTCAE

description: Incisional separation, local care (e.g., suturing) or medical intervention indicated (e.g., analgesic)


Grade 4 Neonatal Constipation, AE

description: A constipation adverse event in a newborn characterized by life-threatening consequences.


Recurrent Primary Cutaneous Lymphoma

description: The reemergence of primary cutaneous lymphoma after a period of remission.


Grade 4 Keratitis, CTCAE

description: Perforation; best corrected visual acuity of 20/200 or worse in the affected eye


Grade 2 Guillain-Barre Syndrome, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Asymptomatic Infections

description: Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps.


name: Serum IgM Monoclonal Gammopathy of Less than 30g/L

description: An abnormal laboratory test result indicating that a serum IgM paraprotein concentration is less than 30g/L.


name: Grade 5 Laryngopharyngeal Dysesthesia, CTCAE

description: Death


Stage IIB Bone Cancer AJCC v8

description: Stage IIB includes: T2, N0, M0, G2 or G3. T2: Tumor measuring more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Advanced Ocular Melanoma

description: Ocular melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Tectal Glioma

description: A glioma that arises from the tectum mesenchephali.


Epididymal Squamous Cell Carcinoma

description: An exceedingly rare carcinoma with squamous differentiation arising from the epididymis.


Grade 5 Hyperuricemia, CTCAE

description: Death


name: Grade 1 Activated Partial Thromboplastin Time Prolonged, CTCAE

description: >ULN-1.5 x ULN


Growth Hormone Abnormal, CTCAE

description: A finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen.


name: Grade 5 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adipsic Diabetes Insipidus

description: Diabetes insipidus complicated by a deficient or absent thirst response to hyperosmolality, usually as a result of hypothalamic damage or dysfunction.


name: WNT-Activated Deep Penetrating/Plexiform Melanocytoma (Nevus)

description: A benign melanocytic neoplasm composed of spindle and/or epithelioid melanocytes and melanophages. It is caused by the combined activation of the WNT signaling and MAP-kinase pathways. It occurs in the head and neck region, trunk, extremities, and conjunctiva. It presents with well-circumscribed, darkly pigmented papules. The neoplastic melanocytes form wedge-shaped, fascicular, or plexiform patterns. Lesions with a wedge-shaped pattern extend into the deep reticular dermis. In plexiform spindle cell lesions, the neoplastic melanocytes proliferate in the upper dermis. A junctional component is present in the majority of cases. It rarely progresses to melanoma.


Recurrent Schwannoma

description: The reemergence of schwannoma after a period of remission.


name: Grade 3 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Infant Acute Biphenotypic Leukemia

description: An acute biphenotypic leukemia that occurs in infancy.


Drug toxicity

description: An adverse effect of a drug used therapeutically or diagnostically.


Grade 3 Jejunal Obstruction, CTCAE

description: Hospitalization indicated; invasive intervention indicated; limiting self care ADL


name: Grade 3 Tongue Intra-Operative Injury, CTCAE


name: Stage IV Gastric Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Non-IgM Monoclonal Gammopathy of Undetermined Significance

description: Monoclonal gammopathy of undetermined significance defined by the presence in the serum of an IgG, IgA, or (rarely) IgD paraprotein at a concentration of less than 30g/L; clonal bone marrow plasma cells less than 10%; and absence of end-organ damage such as hypercalcemia, renal insufficiency, anemia, bone marrow lesions, and amyloidosis attributable to the plasma cell proliferative disorder. The risk of progression to plasma cell myeloma, light-chain amyloidosis, or a related disorder is 1% per year. (WHO 2017)


name: Grade 3 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Metastatic Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Meningeal Lymphoma

description: Involvement of the meninges by Hodgkin or non-Hodgkin lymphoma.


Grade 2 Paresthesia, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Xerostomia caused by ionizing radiation

description: Dryness of the oral mucosa secondary to radiation therapy.


Grade 4 Middle Ear Inflammation, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 4 Arterial Injury, CTCAE

description: Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


name: Recurrent Acute Myeloid Leukemia with KMT2A Rearrangement

description: The reemergence of acute myeloid leukemia with KMT2A rearrangement after a period of remission.


name: Grade 1 Sciatic Nerve Intra-Operative Injury, CTCAE


Urinary System Paraganglioma

description: An extra-adrenal paraganglioma that arises from the urinary system.


name: Grade 2 Carbon Monoxide Diffusion Capacity, CTCAE


Grade 4 Laryngeal Edema, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Refractory Lymphoproliferative Disorder

description: Lymphoproliferative disorder that is resistant to treatment.


Grade 2 Fracture, CTCAE

description: Symptomatic but non-displaced; immobilization indicated


Penile Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the penis. Representative examples include phimosis, balanitis, and hypospadias.


name: Grade 3 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: large cell neuroendocrine carcinoma of appendix

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix.  It is characterized by the presence of malignant large cells.


name: Grade 4 Hemorrhage and Bleeding, CTCAE Associated with Surgery, CTCAE


Childhood Bone Neoplasm

description: A bone neoplasm that occurs during childhood.


Grade 1 Middle Ear Inflammation, CTCAE

description: Serous otitis


Stage IVB Uterine Corpus Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa). (from AJCC 8th Ed.)


Neoplasm of broad ligament

description: A benign, borderline, or malignant neoplasm that affects the broad ligament.


Bronchial Stricture, CTCAE

description: A disorder characterized by a narrowing of the bronchial tube.


name: Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: Chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.


Stage I Cervical Cancer FIGO 2009

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2009)


Refractory Gliosarcoma

description: A gliosarcoma that is resistant to treatment.


name: Grade 1 Spleen Intra-Operative Injury, CTCAE


Spinal vascular disorder

description: A disorder that is caused by pathologic changes in the spinal vasculature.


Kidney Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm arising from the kidney. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


name: Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

description: A disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet. Also known as Hand-Foot Syndrome.


Esophageal Schwannoma

description: A slowly growing, benign, usually encapsulated neoplasm arising from the esophagus.  Morphologically, it is composed of neoplastic differentiated Schwann cells.


name: Stage III Gestational Trophoblastic Tumor AJCC v7

description: Stage III includes: (Any T, M1a, Risk factors: unknown); IIIA (Any T, M1a, Risk factors: low risk); IIIB (Any T, M1a, Risk factors: high risk).  M1a: Lung metastasis.  (AJCC 7th ed.)


Grade 3 Night Blindness, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Posthemorrhagic hydrocephalus

description: An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a later sequela of an intraventricular or subarachnoid hemorrhage.


name: Grade 3 Laryngopharyngeal Dysesthesia, CTCAE

description: Severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL


name: Grade 3 Lumbar Spine Range of Motion, CTCAE


name: Grade 3 Cranial Nerve II Intra-Operative Injury, CTCAE


Mixed Phenotype Acute Leukemia, B/T

description: A very rare mixed phenotype acute leukemia in which the blasts show clear-cut evidence of both B-cell and T-cell lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


name: Grade 3 Biliary Tree NOS Intra-Operative Injury, CTCAE


Infrequent Neoplasm

description: A neoplasm that is uncommon.


Southern tick-associated rash illness

description: A putative Borrelia infection causing acute manifestations similar to Lyme disease, particularly erythema migrans, following the bite of the lone star tick, Amblyomma americanum.


RAD51 Low

description: An indication that low expression of RAD51 has been detected in a sample.


name: Localized Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor confined to area of origin including abdominal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 4 Jejunal Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Refractory Osteosarcoma

description: Osteosarcoma that does not respond to treatment.


Cervical Mucoepidermoid Carcinoma

description: A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


name: Grade 4 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Salivary Gland Fistula, CTCAE

description: Invasive intervention indicated


name: Grade 1 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Gastric Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a gastric neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to gastric "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3). Gastric high-grade neuroendocrine carcinoma and gastric mixed adenoneuroendocrine carcinoma are not included in this staging system. (from AJCC 8th Ed.)


name: Grade 4 Hepatic Vein Intra-Operative Injury, CTCAE


Grade 1 Neuralgia, CTCAE

description: Mild pain


name: Grade 3 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Penis Intra-Operative Injury, CTCAE


Refractory AL Amyloidosis

description: AL amyloidosis that does not respond to treatment.


name: Grade 4 Bone Growth Limb Length Discrepancy, CTCAE


name: Grade 2 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Pure Cutaneous Mastocytosis

description: Mastocytosis that manifests with pure cutaneous involvement.


name: Gastrointestinal Tract Acute Graft Versus Host Disease

description: Acute graft versus host disease occurring in the gastrointestinal tract.


Grade 3 Urticaria, CTCAE

description: Urticarial lesions covering >30% BSA; IV intervention indicated


Grade 1 Esophageal Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 5 Hemorrhage and Bleeding, CTCAE Associated with Surgery, CTCAE


Grade 3 Aphonia, CTCAE

description: Voicelessness; unable to speak


name: Stage III Ampulla of Vater Cancer AJCC v8

description: Stage III includes: IIIA: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0); IIIB: (T4, Any N, M0); (Any T, N2, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, irrespective of size. N1: Metastasis to one to three regional lymph nodes. N2: Metastasis to four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Hodgkin's disease lymphocyte predominance type stage III

description: Stage III adult Hodgkin disease means the involvement of lymph node regions on both sides of the diaphragm (III), which may also be accompanied by localized involvement of an associated extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or by involvement of both (IIIE + S). Stage III disease may be subdivided by anatomic distribution of abdominal involvement or by extent of splenic involvement. Stage III(1) indicates involvement that is limited to the upper abdomen above the renal vein. Stage III(2) indicates involvement of pelvic and/or para-aortic nodes. Five or more visible splenic nodules on a cut section constitutes extensive splenic involvement. Zero to four nodules is classified as minimal splenic disease. (from PDQ)


Zoonoses

description: Infection by an etiologic agent that can be passed between animals and humans.


Renal Pelvis and Ureter Carcinoma

description: Carcinoma that affects the renal pelvis and ureter.


Grade 3 Kidney Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Bacterial pericarditis

description: Pericarditis that is caused by an infection with a bacterial agent.


Paratesticular malignant neoplasm

description: A primary or metastatic malignant neoplasm that affects the paratesticular structures.


Resectable Malignant Neoplasm

description: Malignant neoplasm that is amenable to surgical resection.


name: Cardiovascular Adverse Effects from Vaccines to Prevent COVID-19

description: A cardiovascular adverse effect that is attributable to or associated with vaccines used to prevent COVID-19.


Breast Nevus

description: A benign melanocytic nevus that arises from the breast skin.


Aphonia, CTCAE

description: A disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).


Acute Myeloid Leukemia with NPM1-MLF1

description: Acute myeloid leukemia associated with NPM1-MLF1 gene fusion.


Adenocarcinoma in adenomatous polyp

description: A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


name: Locally Advanced Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Congenital facial nerve palsy

description: Partial or complete paralysis of the facial muscles of one side of an individual's face that is present at birth. It is caused by damage to the seventh cranial nerve.


Hypothyroxinemia

description: Decreased concentration of thyroxine.


Grade 1 Lactation Disorder, CTCAE

description: Mild changes in lactation, not significantly affecting production or expression of breast milk


Low Grade Sarcoma

description: A sarcoma with the morphologic features of a low-grade tumor and presence of cellular differentiation.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol.


name: Vulvar Small Cell Neuroendocrine Carcinoma

description: A rare small cell neuroendocrine carcinoma that arises from the vulva.


Peritoneal Infection

description: An infectious process affecting the peritoneum.


Stage IVA Vaginal Cancer AJCC v6 and v7

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4).  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Viremia, CTCAE

description: A disorder characterized by the presence of a virus in the blood stream.


Gastrointestinal Fistula, CTCAE 5.0

description: A disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site.


Gastric Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures).


name: Grade 2 Neuralgia and Peripheral Nerve Pain, CTCAE


Advanced Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Corneal foreign body (disorder)

description: External material in or on the cornea.


name: Grade 1 Genitourinary Stoma Stricture or Stenosis, CTCAE


Stage IIB Cervical Cancer FIGO 2018

description: Cervical carcinoma with parametrial involvement but not up to the pelvic wall. (FIGO 2018)


name: Grade 2 Intraoperative Ocular Injury, CTCAE

description: Partial resection of injured organ/structure indicated


Parapsoriasis en Plaques

description: A variant of parapsoriasis in which the plaques are large.


Grade 4 Anxiety, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 2 Bronchial Obstruction, CTCAE

description: Symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators)


Grade 4 Hematosalpinx, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 3 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Unresectable Cutaneous Melanoma

description: A skin melanoma that is not amenable to surgical resection.


name: Grade 5 Nodal or Junctional Rhythm, CTCAE


name: Grade 1 Major Visceral Vein Intra-Operative Injury, CTCAE


Grade 4 Wound Dehiscence, CTCAE

description: Life-threatening consequences; symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated


name: Grade 4 Intraoperative Respiratory Injury, CTCAE


name: Grade 2 Esophageal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Cutaneous Perineurioma

description: A rare perineurioma arising from the skin.


Grade 2 Iron Overload, CTCAE

description: Moderate symptoms; intervention not indicated


Late Prosthetic Valve Endocarditis

description: Prosthetic valve endocarditis that occurs several months to years following valve replacement.


name: Grade 4 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Recurrent Atypical Chronic Myeloid Leukemia

description: The reemergence of atypical chronic myeloid leukemia after a period of remission.


Grade 1 Jejunal Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Lung Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Radiation damage to artery

description: A damage to arteries caused by radiation therapy.


Grade 3 Epistaxis, CTCAE

description: Transfusion; invasive intervention indicated (e.g., hemostasis of bleeding site)


name: Postoperative Spindle Cell Nodule of the Cervix

description: A rare, benign, non-neoplastic reactive lesion that develops in the cervix at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


name: Grade 1 Rectum Intra-Operative Injury, CTCAE


Grade 3 Peritoneal Necrosis, CTCAE

description: Tube feeding or TPN indicated; invasive intervention indicated


name: Metastatic Malignant Neoplasm in the Digestive System

description: A malignant neoplasm that has spread to the digestive system from another anatomic site.


Grade 2 Cataract, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); glare symptoms affecting instrumental ADL


Stage III Cutaneous Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 1 Bone Marrow Hypocellular, CTCAE

description: Mildly hypocellular or <=25% reduction from normal cellularity for age


Inflamed Juvenile Conjunctival Nevus

description: A compound nevus that arises from the conjunctiva in children and adolescents. It is characterized by the presence of chronic inflammatory features.


Unresectable Myxoid Liposarcoma

description: A myxoid liposarcoma that is not amenable to surgical resection.


Cheilitis, CTCAE

description: A disorder characterized by inflammation of the lip.


Grade 4 Hyperthyroidism, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Edema of the Trunk and Genital Area, CTCAE


name: Grade 3 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Fallopian Tube Hemorrhage, CTCAE


name: Disseminated Intravascular Coagulation Related to COVID-19

description: Disseminated intravascular coagulation in a patient with probable or confirmed acute COVID-19.


name: Grade 4 Neonatal Culture Negative Sepsis, AE

description: A culture negative neonatal sepsis adverse event in a newborn characterized by life-threatening consequences (e.g. shock, disseminated intravascular coagulation (DIC)); urgent major care change required.


name: Grade 5 Pneumonitis and Pulmonary Infiltrates, CTCAE


name: Upper Aerodigestive Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Grade 2 Gamma-Glutamyl Transpeptidase, CTCAE


name: Stage III Adult Diffuse Mixed Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


name: Grade 4 Urinary Tract Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Appendix Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas of the appendix, including high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and goblet cell carcinoids. Well-differentiated neuroendocrine tumors (carcinoids) are staged according to the classification for neuroendocrine tumors of the appendix. (from AJCC 8th Ed.)


Grade 3 Capillary Leak Syndrome, CTCAE

description: Severe symptoms; intervention indicated


Stage IA Vulvar Carcinoma AJCC v6

description: Stage IA includes: Tia, N0, M0.  T1a: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion no greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Assault by firearms

description: A physical attack with a gun.


Adenocarcinoma of the prostate stage II

description: Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


name: Long-Term Effects Secondary to Cancer Therapy

description: Side effects of cancer treatment occurring a long time after the treatment was completed.


name: Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

description: A disorder characterized by headaches, mental status changes, visual disturbances, and/or seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition. Also known as posterior reversible encephalopathy syndrome (PRES).


name: Advanced Malignant Digestive System Neoplasm

description: A malignant digestive system neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Intraoperative Breast Injury, CTCAE

description: Partial resection of injured organ/structure indicated


Grade 1 Pneumothorax, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 4 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Localized Gastric Adenocarcinoma

description: An adenocarcinoma that arises from the stomach and has not spread to other anatomic sites.


Subjective Fever

description: A symptom report of fever without an objective temperature measurement.


name: FIGO Stage III Gestational Trophoblastic Tumor

description: Lesion affects the lungs, with or without known genital structures invasion.


name: Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: A chronic myeloid leukemia, BCR-ABL1 positive occurring during childhood.


Grade 1 Myasthenia Gravis, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Chemically Induced Cardiotoxicity

description: Damage or injury to the heart caused by a chemical agent.


Mucosal nodular melanoma

description: Nodular melanoma that arises from a mucosal site.