Adult Central Nervous System Neoplasm

description: A benign or malignant neoplasm of the brain, spinal cord, or meninges occurring in adults.  Representative examples of primary neoplasms include astrocytoma, meningioma, pituitary adenoma, and neurilemoma.  Representative examples of tumor metastases from other organs to the central nervous system include lung and breast carcinoma.


Nail Apparatus Melanoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A melanoma that arises from the nail plate.


name: Grade 3 Tendon Intra-Operative Injury, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


name: Grade 2 Associated with Dentures or Dental Prosthesis, CTCAE


Grade 3 Eye Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 2 Abdomen Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Benign Diencephalic Neoplasm

description: A neoplasm that arises from the diencephalon and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 1 Suicidal Ideation, CTCAE

description: Increased thoughts of death but no wish to kill oneself


name: Grade 5 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

description: Skin changes (e.g., peeling, blisters, bleeding, fissures, edema, or hyperkeratosis) with pain; limiting instrumental ADL


name: Grade 1 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 1 Anal Ulcer, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 2 Gastric Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Grade 2 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: T Acute Lymphoblastic Leukemia with TLX3 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of TLX3 gene rearrangement.


Stage III Prostate Cancer AJCC v8

description: Stage III includes: IIIA: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; IIIB: T3-4, N0, M0, PSA: Any, Grade Group 1-4; IIIC: Any T, N0, M0, PSA: Any, Grade Group 5. T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. T3: Prostate cancer with extraprostatic tumor that is not fixed or does not invade adjacent structures. T4: Prostate cancer in which the tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


name: Grade 1 Cranial Nerve I Neuropathy, CTCAE


recurrent gastric cancer

description: The reemergence of gastric carcinoma after a period of remission.


Grade 3 Weight Gain, CTCAE

description: >=20% from baseline


name: Coinfection of COVID-19 with Other Respiratory Infections

description: A respiratory infection that is diagnosed concurrently during an episode of acute illness caused by SARS-CoV-2.


name: Grade 4 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Eosinophilia, CTCAE

description: >ULN and >Baseline


Grade 2 Jejunal Stenosis, CTCAE

description: Symptomatic; altered GI function


name: Grade 3 Stoma GI Stricture or Stenosis, CTCAE


name: Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Tooth Development Disorder, CTCAE

description: Asymptomatic; hypoplasia of tooth or enamel


Grade 1 Palpitations, CTCAE

description: Mild symptoms; intervention not indicated


Chronic superficial gastritis

description: Persistent inflammation of the superficial portion of the gastric mucosa.  It is a condition that predisposes to the development of ulcer and mucosa-associated lymphoid tissue lymphoma.


name: Grade 2 Prostate Stricture or Stenosis, CTCAE


Cecal Infection, CTCAE

description: A disorder characterized by an infectious process involving the cecum.


name: Grade 5 Vagina Stricture or Stenosis, CTCAE


name: Grade 2 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 3 Trochlear Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


name: Stage II Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor limited to the pancreas and measuring 2-4 cm. T3: Tumor limited to the pancreas and measuring more than 4 cm; or tumor invading the duodenum or bile duct. N0: No regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 1 Dermal Change Lymphedema or Phlebolymphedema, CTCAE


Bladder Hemangioma

description: A hemangioma that arises from the bladder. Most tumors occur in adults.


name: Primary malignant neoplasm of independent multiple sites

description: A malignant neoplasm arising in multiple primary sites.


Grade 2 Enterovesical Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Abnormal Glucose Level Finding

description: A finding that either fasting or postprandial blood glucose levels are above or below the normal thresholds.


name: Grade 5 Neonatal Pulmonary Hemorrhage, AE

description: A pulmonary hemorrhage adverse event in a newborn which results in death.


name: Grade 3 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Vaginal Infection, CTCAE

description: Death


Bowenoid Actinic Keratosis

description: Actinic keratosis characterized by the presence of usually focal, nearly full-thickness squamous atypia.


name: Lymphoma/Leukemia by Kiel Classification (Antiquated)


name: Grade 4 Colon Stricture or Stenosis, CTCAE


name: Grade 3 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Dysuria, CTCAE

description: A disorder characterized by painful urination.


name: Grade 2 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Gastric neuroendocrine carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Pericardial Effusion, CTCAE

description: A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation.


name: Grade 4 Spermatic Cord Perforation, CTCAE


name: Grade 5 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IIIB Gastric Carcinoma

description: Stage IIIB includes: (T4b, N0, M0); (T4b, N1, M0); (T4a, N2, M0); (T3, N3, M0).  T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Systemic Disorder

description: An inherited disorder that presents with systemic manifestations.


name: Grade 2 Pyramidal Tract Dysfunction, CTCAE


name: Grade 3 Biliary Tree Stricture or Stenosis, CTCAE


Grade 3 Hepatitis Viral, CTCAE

description: Symptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; hospitalization or prolongation of existing hospitalization indicated


name: Grade 3 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Serum Hypertriglyceridemia, CTCAE


name: Rash and Dermatitis Associated with Radiation, CTCAE


name: Gastroesophageal Junction Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage

description: A term that refers to the postneoadjuvant therapy staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Acute Myocardial Injury with Left Ventricular Dysfunction Related to COVID-19

description: Acute myocardial injury with evidence of new systolic dysfunction with reduced left ventricular ejection (LVEF less than 50%) in a patient with probable or confirmed acute COVID-19.


name: Grade 3 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Vulval intraepithelial neoplasia grade 2

description: An intraepithelial lesion of the vulvar squamous epithelium associated with HPV infection. It is characterized by loss of maturation, nuclear hyperchromasia, high nuclear:cytoplasmic ratios, cytological and architectural atypia, and mitoses. Two morphological patterns have been described: basaloid (undifferentiated) and warty (condylomatous, bowenoid). It carries a significant but relatively low risk of progression to squamous cell carcinoma if untreated. (WHO 2020)


Intestinal Stoma Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of the contents of the intestinal stoma.


name: Grade 1 Large Intestinal Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Stage I Cutaneous Melanoma AJCC v6

description: Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0); (T2a, N0, M0).  T1a: Melanoma is less than or equal to 1.0mm in thickness with or without ulceration.  T1b: Melanoma is less than or equal to 1.0mm in thickness and level IV or V with ulceration. T2a: Melanoma 1.01-2.0 mm in thickness, no ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis.-2003


name: Grade 3 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Infusion Related Reaction, CTCAE

description: Mild transient reaction; infusion interruption not indicated; intervention not indicated


name: Grade 3 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


Cortical Cataract Grade 3

description: A stage of cortical cataract characterized by 50-90% of the intrapupillary space obscured by opacity. (Modified LOCS II)


name: Grade 3 Supraventricular Arrhythmia NOS, CTCAE


name: Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


name: Grade 5 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Gastric Schwannoma

description: A rare schwannoma that arises from the stomach.  It follows a benign clinical course.


name: Grade 1 Other Musculoskeletal and Soft Tissue, CTCAE


Climacteric arthritis

description: Arthritis that occurs during menopause.


Grade 5 Pericardial Effusion, CTCAE

description: Death


Grade 5 Lymph Gland Infection, CTCAE

description: Death


name: Grade 1 Neonatal Coagulation Disorder, AE

description: An adverse event in a newborn characterized by minor biochemical coagulation abnormalities without clinical signs; no care changes indicated.


Grade 2 Vaccination Complication, CTCAE

description: Moderate pain; Erythema 5.1-10 cm; Induration/swelling 5.1-10 cm; lipodystrophy; limiting instrumental ADL


Advanced Skin Squamous Cell Carcinoma

description: Skin squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Adult Diffuse Astrocytoma

description: A low grade (WHO grade II) astrocytoma occurring during adulthood.  It is characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures.


name: Grade 2 Neonatal Culture Negative Sepsis, AE

description: An adverse event in a newborn characterized by suspected sepsis with mild or ambiguous signs; anti-infectives initiated.


Chronic systolic heart failure

description: Chronic congestive heart failure due to reduced contractility of the left ventricle.


name: Grade 2 Sciatic Nerve Intra-Operative Injury, CTCAE


Recurrent Ependymal Tumor

description: The reemergence of an ependymal tumor after a period of remission.


name: Grade 2 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage III Vulvar Cancer AJCC v6

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N0, M0); (T3, N1, M0).  T3: Tumor of any size with contiguous spread to the lower urethra and/or vagina or anus. N1: Unilateral regional lymph node metastasis. M0: No distant metastasis.  (AJCC 6th ed.)


name: Grade 4 Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Myelodysplastic Syndrome, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Thoracic Duct Intra-Operative Injury, CTCAE


Grade 1 Sinus Disorder, CTCAE

description: Asymptomatic mucosal crusting; blood-tinged secretions


name: Metastatic Giant Cell Urothelial Carcinoma

description: Giant cell urothelial carcinoma that has spread to another anatomic site.


name: Grade 3 Gastrointestinal Stoma Necrosis, CTCAE

description: Severe symptoms; hospitalization indicated; elective operative intervention indicated


Metastatic malignant neoplasm to anus

description: An epithelial or non-epithelial malignant neoplasm that has spread to the anus from another anatomic site.


Recurrent Hodgkin Lymphoma

description: The reemergence of Hodgkin lymphoma after a period of remission.


Neoplastic Nodule

description: A benign or malignant growth composed of proliferating neoplastic cells.


Grade 5 Dermatitis Radiation, CTCAE

description: Death


Grade 2 Eye Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Lower Gastrointestinal Hemorrhage NOS, CTCAE


name: Low Grade Anal Intraepithelial Neoplasia

description: Anal canal or perianal skin intraepithelial neoplasia with mild dysplasia.


Botryoid odontogenic cyst

description: The multicystic variant of lateral periodontal cyst. (WHO 2017)


name: Malignant Accessory Urethral Gland Neoplasm

description: A malignant neoplasm involving the accessory urethral glands.


name: Lip Or Perioral Area Intra-Operative Injury, CTCAE


name: Grade 2 Intraoperative Neurological Injury, CTCAE

description: Partial resection of injured organ/structure indicated


Vaginal Pain

description: A painful sensation in the vagina.


Condyloma anal

description: A human papillomavirus-related neoplasm arising from the anus. Morphologically, it is characterized by an exophytic papillary proliferation of squamous cells and acanthosis.


Infective Myositis, CTCAE

description: A disorder characterized by an infectious process involving the skeletal muscles.


Focal Mammary Duct Ectasia

description: Localized widening of the lumen of the mammary ducts.


name: Metastatic Bladder Sarcomatoid Urothelial Carcinoma

description: Bladder sarcomatoid urothelial carcinoma that has spread to another anatomical site.


name: Psychosis Including Hallucinations and Delusions, CTCAE


Pitting Edema

description: Swelling due to excessive accumulation of fluid under the skin defined by a persistent indentation when pressure is applied to the swollen area.  Causes include systemic conditions (e.g., heart failure, liver failure, or kidney failure) and local conditions affecting the extremities.


Grade 1 Bronchospasm, CTCAE

description: Mild symptoms; intervention not indicated


name: Childhood L1 Acute Lymphoblastic Leukemia

description: L1 acute lymphoblastic leukemia that occurs during childhood.


Neoplasm of lacrimal duct

description: A benign or malignant neoplasm that affects the lacrimal duct.


Sickle Beta Plus Thalassemia

description: A mild form of sickle cell thalassemia characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells. It is characterized by the presence of small red blood cells and mild anemia.


name: Grade 4 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Delayed Orgasm, CTCAE

description: Delay in achieving orgasm not adversely affecting relationship


name: Refractory Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma, not otherwise specified, that is resistant to treatment.


name: Recurrent Anaplastic (Malignant) Meningioma

description: The reemergence of anaplastic (malignant) meningioma after a period of remission.


Grade 3 Arteritis Infective, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 1 Non-Infectious Wound Complication, CTCAE


Urostomy Stenosis, CTCAE

description: A finding of narrowing of the opening of a urostomy.


name: Metabolic or Respiratory Alkalosis, CTCAE


Hypopituitarism, CTCAE

description: A disorder characterized by a decrease in production of hormones from the pituitary gland.


Biclonal gammopathy

description: A primary disturbance in immunoglobulin synthesis characterized by the presence of two distinct monoclonal immunoglobulins in the serum or urine.


Vaccination Site Lymphadenopathy, CTCAE

description: A disorder characterized by lymph node enlargement after vaccination


name: Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Cyst of biliary tract

description: A cystic dilatation that occurs in any part of the biliary tree.


Malignant Lymphoma, Large Cell Type

description: An antiquated term that refers to a morphologic variant of non-Hodgkin lymphoma which is composed predominantly or exclusively of large neoplastic lymphocytes.


Decreased NCF4 Expression

description: An indication that the expression of NCF4 is lower than the normal range of values.


Grade 5 Stridor, CTCAE

description: Death


name: Grade 5 Spermatic Cord Stricture or Stenosis, CTCAE


name: Grade 1 Spermatic Cord Stricture or Stenosis, CTCAE


Grade 4 Stoma Site Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Grade 4 Bladder Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 3 Dyspepsia, CTCAE

description: Severe symptoms; operative intervention indicated


name: Adverse Event Associated with Metabolic and Laboratory Abnormalities


Grade 2 Hot Flashes, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 4 Acidosis, CTCAE

description: Life-threatening consequences


name: Grade 4 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Fall, CTCAE

description: Hospitalization indicated; invasive intervention indicated


Bladder Sphincter Dysfunction

description: Non-coordinated, reflexive contraction of the bladder and sphincter relaxation.


Grade 1 Pain, CTCAE

description: Mild pain


Injury of lumbar spinal cord

description: An injury to the lumbar spinal cord.


Grade 1 Dysarthria, CTCAE

description: Mild slurred speech


name: Grade 2 Cranial Nerve XII Intra-Operative Injury, CTCAE


Congenital supraventricular tachycardia

description: A disorder present at birth characterized by an electrocardiographic finding of a tachycardia that originates above the ventricles.


Grade 5 Wound Complication, CTCAE

description: Death


Refractory Malignant Bone Neoplasm

description: Malignant bone neoplasm that is resistant to treatment.


name: Invasive Microcystic Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by microcysts formation.


name: Grade 2 Intraoperative Arterial Injury, CTCAE

description: Partial resection of injured organ/structure indicated


name: Stage IVA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Gallbladder Papillary Adenoma

description: An adenoma that arises from the gallbladder.  It is characterized by the presence of a papillary growth pattern.


name: Grade 3 Personality and Behavioral Change, CTCAE


Recurrent Aplastic Anemia

description: The reemergence of aplastic anemia after a period of remission.


name: Developmental and Epileptic Encephalopathy 9

description: An X-linked subtype of developmental and epileptic encephalopathy caused by mutation(s) in the PCDH19 gene, encoding protocadherin-19.


name: Grade 2 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Rash Hand or Foot Skin Reaction, CTCAE


name: Vaginal Mucinous Adenocarcinoma, Gastric-Type

description: Vaginal mucinous adenocarcinoma characterized by the presence of gastric differentiation.


name: Aromatic Dyes-Related Malignant Neoplasm


Childhood Glioblastoma

description: A glioblastoma that occurs during childhood.


Childhood Low Grade Fibromyxoid Sarcoma

description: A low-grade fibromyxoid sarcoma that occurs during childhood.


name: Precursor T-lymphoblastic lymphoma/leukemia stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (Rare in Hodgkin lymphoma).


name: Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Adult Primary Meningeal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the leptomeninges and occurs during adulthood.


name: Radiating Chest Pain Along Left Anterior Axillary Line

description: The location of the radiating chest pain is along the left anterior axillary line.


Stage II Prostate Cancer AJCC v6

description: Stage II includes: (T1a, N0, M0, G2, 3-4); (T1b, N0, M0, Any G); (T1c, N0, M0, Any G); (T1, N0, M0, Any G); (T2, N0, M0, Any G).  T1: Clinically inapparent tumor neither palpable nor visible by imaging.  T1a: Tumor incidental histologic finding in 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g. because of elevated PSA).  T2: Tumor confined with in the prostate.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G2: Moderately differentiated (moderate anaplasia) (Gleason 5-6). G 3-4: Poorly differentiated/undifferentiated (marked anaplasia) (Gleason 7-10).  (AJCC 6th ed.)


Grade 4 Vomiting, CTCAE

description: Life-threatening consequences


Treatment related leukaemia

description: A leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation.


name: Grade 3 Neutrophils and Granulocytes, CTCAE


Grade 3 Perineal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 4 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 1 Retina Intra-Operative Injury, CTCAE


name: Grade 4 Non-Malignant Pericardial Effusion, CTCAE


name: Grade 1 Cardiac Troponin I Increased, CTCAE

description: Levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer


Trochlear Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the trochlear nerve (fourth cranial nerve).


name: Grade 2 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Adult Grade II Meningioma

description: A grade II meningioma that occurs during adulthood.


name: Appendix High Grade Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix.  It is characterized by the presence of moderate or severe dysplasia and complex architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


name: Metastatic Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


Grade 3 Lymphocele, CTCAE

description: Severe symptoms; invasive intervention indicated


Serum CA 19-9 Elevated

description: The amount of cancer antigen 19-9 present in a serum sample is elevated.


name: Grade 2 Anal Sphincter Intra-Operative Injury, CTCAE


name: Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Verrucous carcinoma of the oral cavity stage III


name: Grade 3 Otitis Middle Ear Non Infectious, CTCAE


Conjunctival Junctional Nevus

description: A junctional nevus that arises from the conjunctiva. It occurs almost exclusively in the juxtalimbal bulbar conjunctiva. It is characterized by an intraepithelial proliferation of type A nevus cells and/ or type B nevus cells.


name: Grade 4 Intraoperative Splenic Injury, CTCAE


Grade III Childhood Astrocytoma

description: An anaplastic astrocytoma that arises from the central nervous system and occurs during childhood.


name: Locally Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 2 Anal Ulcer, CTCAE

description: Symptomatic; altered GI function


name: Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder

description: A clonal T-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed T-lymphocytes/NK-cells.  The clonal cellular infiltrates fulfill the criteria for any of the T-cell or natural killer cell lymphomas.


Grade 3 Renal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 2 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Esophageal and Gastroesophageal Junction Carcinoma

description: A carcinoma that arises from the esophagus or gastroesophageal junction.


name: Grade 4 Small Bowel Stricture or Stenosis NOS, CTCAE


Grade 2 Endophthalmitis, CTCAE

description: Local intervention indicated


name: Grade 4 Scleral Necrosis and Melt, CTCAE


De Novo Nodular Melanoma

description: A nodular melanoma that does not arise from a nevus and lacks a radial growth phase.


name: Grade 2 Salivary Duct Inflammation, CTCAE

description: Thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL


name: Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps), CTCAE


name: Grade 5 Small Intestinal Stenosis, CTCAE

description: Death


Grade 3 Bone Marrow Hypocellular, CTCAE

description: Severely hypocellular or >50-<=75% reduction cellularity from normal for age


name: Grade 4 Slipped Capital Femoral Epiphysis, CTCAE


Grade 4 Gastric Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Refractory Squamous Cell Carcinoma

description: Squamous cell carcinoma that is resistant to treatment.


Congenital Adrenal Gland Disorder

description: A genetic disorder that affects the adrenal gland.  It includes adrenal gland hyperplasia and adrenal gland hypoplasia.


Non-Neoplastic Gonadal Disorder

description: A non-neoplastic disorder that affects the testis or the ovary. Representative examples include gonadal agenesis, dysgenesis, and hypogonadism.


name: Grade 5 Neonatal Respiratory Distress Syndrome, AE

description: A respiratory distress adverse event in a newborn which results in death.


name: Stage IV Renal Pelvis and Ureter Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into the perinephric fat.  N0: No regional lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  N1: Distant metastasis.  (AJCC 7th ed.)


name: Lower Gastrointestinal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).


Schizophrenia, Childhood

description: Schizophrenia occurring in childhood.


name: Grade 4 Muscle Intra-Operative Injury, CTCAE


name: Grade 1 Pancreatic Enzymes Decreased, CTCAE

description: <LLN and asymptomatic


name: Grade 4 Intraoperative Arterial Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Invasive Prostate Carcinoma

description: A carcinoma that is not confined to the prostatic epithelium but has spread to the surrounding stroma of the prostate gland.  The vast majority of invasive prostate carcinomas are adenocarcinomas.


Grade 2 Conjunctivitis Infective, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Retroperitoneal disorder

description: A non-neoplastic or neoplastic disorder that affects the retroperitoneum.


Non-Neoplastic Anal Disorder

description: A non-neoplastic disorder that affects the anus. Representative examples include hemorrhoids, ulcers, and infections.


Ileus, CTCAE

description: A disorder characterized by failure of the ileum to transport intestinal contents.


name: Grade 2 Gastrointestinal Stoma Leak, CTCAE


Grade 1 Chronic Kidney Disease, CTCAE

description: eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN-60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5


name: Grade 2 Carbon Monoxide Diffusing Capacity Decreased, CTCAE

description: 6-8 units below LLN; for follow-up, an asymptomatic decrease of >5-8 units (ml/min/mm Hg) below the baseline value; symptomatic and intervention not indicated


Grade 4 Delusions, CTCAE

description: Life-threatening consequences, threats of harm to self or others; hospitalization indicated


name: Grade 2 Uterus Intra-Operative Injury, CTCAE


name: Grade 5 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Personality and Behavioral Change, CTCAE


name: Clear Cell Tumor with Melanocytic Differentiation and ACTG1-MITF Translocation

description: A clear cell tumor with melanocytic differentiation characterized by a cytogenetic translocation between ACTG1 and MITF genes that results in ACTG1-MITF gene fusion.


Grade 2 Suicidal Ideation, CTCAE

description: Suicidal ideation with no specific plan or intent


name: Benign Accessory Urethral Gland Neoplasm

description: A neoplasm that arises from the accessory urethral glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Trigeminal Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the trigeminal nerve (fifth cranial nerve).


name: Grade 4 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


name: Grade 1 Testes Stricture or Stenosis, CTCAE


Grade 5 Gastric Perforation, CTCAE

description: Death


name: Genitourinary Stoma Stricture or Stenosis, CTCAE


name: Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Childhood Ependymal Tumor

description: An ependymal tumor that occurs during childhood.


name: Recurrent Fallopian Tube High Grade Serous Adenocarcinoma

description: The reemergence of fallopian tube high-grade serous adenocarcinoma after a period of remission.


Grade 1 Nipple Deformity, CTCAE

description: Asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex


Stage II Anal Cancer AJCC v8

description: Stage II includes: IIA: T2, N0, M0; IIB: T3, N0, M0. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Pancreatic Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage M2 Childhood Ependymoma by Toronto Guidelines v2

description: Visible metastasis in brain. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Aggressive Prostate Adenocarcinoma

description: Prostate adenocarcinoma that metastasizes quickly to other anatomic sites. It usually has a Gleason score between 8 and 10, a PSA level higher than 20 ng/ml, and is classified as T3b or T4.


name: Stage IVC Oral Cavity Verrucous Carcinoma


name: Grade 3 Neonatal Respiratory Distress Syndrome, AE

description: An adverse event in a newborn characterized by clinical evidence of increased respiratory distress with relevant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); requiring major care change (e.g. starting invasive support).


name: Autosomal Dominant Congenital Myopathy-1A

description: An autosomal dominant condition caused by mutation(s) in the RYR1 gene, encoding ryanodine receptor 1. The phenotype is variable, but generally includes weakness in the proximal muscles of the lower limb and individuals are at increased risk for malignant hyperthermia.


Kidney Neuroendocrine Neoplasm

description: An epithelial neoplasm with neuroendocrine differentiation that arises from the kidney.  It includes neuroendocrine tumor, small cell neuroendocrine carcinoma, large cell neuroendocrine carcinoma, and paraganglioma.


Cancer-Associated Anorexia

description: Loss of appetite associated with cancer or its treatment.


Locally Advanced Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has spread to nearby tissues or lymph nodes.


Chronic Right Heart Failure

description: Persistent and long-standing right heart failure.


Grade 5 Esophageal Obstruction, CTCAE

description: Death


name: Grade 1 Renal and Urinary Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Advanced Mucosal Melanoma

description: Mucosal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Pruritus, CTCAE

description: Widespread and constant; limiting self care ADL or sleep; systemic corticosteroid or immunosuppressive therapy indicated


name: Grade 1 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


Grade 2 Bladder Spasm, CTCAE

description: Antispasmodics indicated


Grade 3 Hallucinations, CTCAE

description: Severe hallucinations; hospitalization not indicated


name: Grade 4 Ureteric Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Schizophrenia, Disorganized

description: A subtype of schizophrenia characterized by disorganized speech, disorganized behavior, and a flat or inappropriate affect; associated features include grimacing, mannerisms, and other oddities of behavior. Criteria for the catatonic type of schizophrenia are not met.


Disease Response

description: The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression.


name: Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Cervical Stratified Mucin-Producing Intraepithelial Lesion

description: A rare, human papillomavirus-associated premalignant glandular intraepithelial neoplasm that arises from the cervix. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin. There is no evidence of stromal invasion. It is distinct from conventional cervical squamous or glandular intraepithelial neoplasias.


Metanephric Tumor

description: A neoplasm arising from the distal convoluted tubule and collecting duct areas of the kidney.


Localized Neoplasm

description: A neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Grade 5 Proctitis, CTCAE

description: Death


Complication of transplant

description: A problem arising from transplantation.


COVID-19-Associated Hematuria

description: Hematuria caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Benign neuroendocrine tumor

description: A paraganglioma that is confined to the site of origin.


Lichenoid Actinic Keratosis

description: Actinic keratosis characterized by the presence of a band-like chronic inflammatory infiltrate in the papillary dermis and vacuolar changes in the basal keratinocytes.


Continent Epispadias

description: Epispadias with urinary continence.


name: Therapy-Related Toxicity - Acceptable to Patient

description: Indicates that a toxicity adverse effect has been experienced by a patient, but it is not severe enough for the patient to discontinue the treatment.


name: Ann Arbor Stage I Supradiaphragmatic Hodgkin Lymphoma


name: stenosis of supravalvular pulmonary artery

description: Stenosis of the pulmonary artery that occurs above the valve.


name: Grade 4 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 2 Periorbital Edema, CTCAE

description: Indurated or pitting edema; topical intervention indicated


Grade 2 Anorectal Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Grade 3 Lower Extremity Soft Tissue Necrosis, CTCAE


Abscess of adrenal gland

description: An abscess that is located in the adrenal gland.


Stage I Esophageal Cancer

description: Stage I includes: T1, N0, M0.  TI: Tumor invades lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) -2003


name: Grade 4 Cecum Intra-Operative Injury, CTCAE


name: Grade 4 Encephalomyelitis Infection, CTCAE


name: Grade 5 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Enteropathic spondylitis

description: A form of spondyloarthritis that is found in some patients with inflammatory bowel disease.


Neck Edema

description: Swelling due to an accumulation of excessive fluid in the neck.


Adult Acute Erythroid Leukemia

description: An acute erythroid leukemia occurring in adults.


name: Cervical Adenocarcinoma, Not Otherwise Specified

description: A cervical adenocarcinoma that cannot be classified by WHO criteria or International Endocervical Adenocarcinoma Criteria and Classification (IECC).


Phlebitis Infective, CTCAE

description: A disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein.


Grade 2 Uveitis, CTCAE

description: Anterior uveitis with 1+ or 2+ cells


Stage IS Testicular Cancer AJCC v8

description: Stage IS includes: Any pT/TX, N0, M0, S1-3. TX: Testicular cancer in which the primary tumor cannot be assessed. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. S3: LDH more than 10 x N or hCG (mlU/mL) more than 50,000 or AFP (ng/mL) more than 10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


name: Radiating Chest Pain Along Midclavicular Line

description: The location of the radiating chest pain is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.


name: Grade 2 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Senile Sebaceous Hyperplasia

description: A hyperplasia of the sebaceous glands. It is usually seen as small yellow papules in the face of middle aged-older population.


Grade 3 Hearing Impaired, CTCAE

description: Adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift of >25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated; Adults not enrolled on a Monitoring Program: Hearing loss with hearing aid or intervention indicated; limiting self care ADL; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Hearing loss sufficient to indicate therapeutic intervention, including hearing aids; threshold shift >20 dB at 2 to < 4 kHz in at least one ear


Malignant blue nevus of skin

description: A rare melanoma which develops in a pre-existing blue nevus. It occurs more frequently on the scalp, face, orbit, back, buttocks, extremities, hands, and feet.


name: Grade 3 Masculinization of Female, CTCAE


name: Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Thoracic Diseases

description: A non-neoplastic or neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, thymoma, mediastinal lymphoma, and pleural mesothelioma.


Localized Esophageal Carcinoma

description: Esophageal carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites.


Appendix Traditional Serrated Adenoma

description: An adenoma that arises from the appendix.  It is characterized by prominent serration of the glands.


Grade 2 Hepatic Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Sign

description: Objective evidence of disease perceptible to the examining healthcare provider.


name: Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Irritation

description: A mild inflammatory tissue reaction; it can be caused by physical contact with an irritant or can be a local response to a systemic trigger.


name: Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


Unanticipated Adverse Event

description: An adverse event that is unexpected, related or possibly related to an individual's participation in the research, and suggests that the research places subjects or others at greater risk of harm than was previously known or recognized.


name: Clinical Stage III Cutaneous Melanoma AJCC v8

description: Stage III includes: Any T, Tis, N1 or More, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N1: One tumor-involved node or in-transit, satellite, and/or microsatellite metastases with no tumor-involved nodes. N2: Two or three tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with one tumor-involved node. N3: Four or more tumor-involved nodes or in-transit, satellite, and/or microsatellite metastases with two or more tumor-involved nodes, or any number of matted nodes without or with in-transit, satellite, and/or microsatellite metastases. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Gastric Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 2 Other Renal or Genitourinary, CTCAE


Keratitis, CTCAE

description: A disorder characterized by inflammation to the cornea of the eye.


name: Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Neonatal Intraventricular Hemorrhage, AE

description: An adverse event in a newborn characterized by asymptomatic hemorrhage confined to the germinal matrix; minimal hemorrhage within the ventricle (less than 10% on parasagittal view).


Recurrent Plasma Cell Leukemia

description: The reemergence of plasma cell leukemia after a period of remission.


Gliomatosis Cerebri Type I

description: A classic form of gliomatosis cerebri. It is characterized by diffuse growth of neoplastic glial tissue without any focal mass.


Grade 1 Mucosal Infection, CTCAE

description: Localized, local intervention indicated


Grade 4 Hematoma, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Laryngeal Inflammation, CTCAE

description: Severe throat pain; endoscopic intervention indicated


Refractory Glioma

description: Glioma that does not respond to treatment.


cytotoxicity

description: The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.


name: Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acute Myeloid Leukemia with FUS-ERG

description: Acute myeloid leukemia associated with FUS-ERG gene fusion. The prognosis is poor.


name: Grade 1 Uterus Intra-Operative Injury, CTCAE


name: Splenic marginal zone lymphoma stage III


Clotting of extracorporeal circuit

description: Thrombus formation within an apparatus that carries blood outside of the body, such as pheresis, dialysis or extracorporeal membrane oxygenation (ECMO).


Grade 5 Cranial Nerve Infection, CTCAE

description: Death


name: Grade 4 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Prostate Intra-Operative Injury, CTCAE


name: Regional Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has not spread to other regions.


Chronic iridocyclitis

description: Uveitis that is usually insidious in onset, bilateral, and can be asymptomatic, most often affecting the anterior uveal tract, including the iris and ciliary body, and can result in long-term complications. It is most commonly associated with certain forms of juvenile idiopathic arthritis, but may occur independent of arthritis.


Castration-Sensitive Prostate Carcinoma

description: Metastatic prostatic carcinoma which is sensitive to androgen-deprivation therapy.


name: Stage I Adult Diffuse Mixed Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Grade 2 Blurred Vision, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline); limiting instrumental ADL


Benign tumor of seminal vesicle

description: A neoplasm that arises from the seminal vesicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Gastrointestinal Anastomotic Leak, CTCAE

description: Death


Ectopic adrenal cortex

description: A term that refers to the presence of benign adrenal cortical tissue outside the adrenal glands.


Conjunctival Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the conjunctiva.


name: Grade 4 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Vaginal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the vagina and another organ or anatomic site.


Portal Vein Thrombosis, CTCAE

description: A disorder characterized by the formation of a thrombus (blood clot) in the portal vein.


name: Cervical intraepithelial neoplasia grade 2

description: Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper half of the squamous epithelium and conspicuous nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal two thirds of the epithelium.


Grade 4 Aortic Valve Disease, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)


name: Grade 1 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Prostate cancer stage A

description: A clinically undetectable tumor confined to the prostate gland, normally an incidental finding during surgery.


name: Autoimmune Lymphoproliferative Syndrome-Related Lymphoma

description: A lymphoma that arises in the context of autoimmune lymphoproliferative syndrome.


name: Grade 5 Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Melanotic neurofibroma

description: A rare neurofibroma characterized by the presence of melanin-laden cells and the absence of atypia.


Apocrine Poroma

description: A poroma with apocrine differentiation.


Grade 2 Vulval Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 2, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 2 Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol.


Grade 3 Tracheal Mucositis, CTCAE

description: Severe pain; hemorrhage or respiratory symptoms; limiting self care ADL


Grade 5 Laryngeal Edema, CTCAE

description: Death


name: Grade 3 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


Pancreatic Cystic Neoplasm

description: A benign, borderline, or malignant cystic neoplasm that arises from the exocrine pancreas. This category includes pancreatic mucinous-cystic neoplasms, pancreatic cystadenomas, and pancreatic cystadenocarcinomas.


name: Grade 1 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 3 Other Musculoskeletal and Soft Tissue, CTCAE


Grade 4 Optic Nerve Disorder, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


Maturing Ganglioneuroma

description: A ganglioneuroma characterized by the presence of differentiating neuroblasts, maturing and mature ganglion cells.


Grade 1 Lymph Node Pain, CTCAE

description: Mild pain


Unresectable Paraganglioma

description: Paraganglioma that is not amenable to surgical resection.


Prostatic Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the prostate gland.


Stage III Osteosarcoma AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 1 Fibrinogen Decreased, CTCAE

description: <1.0-0.75 x LLN; if abnormal, <25% decrease from baseline


name: Grade 3 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


Grade 3 Amnesia, CTCAE

description: Severe; long term memory loss; limiting self care ADL


Fever Chills

description: Shivering secondary to a febrile process.


name: Grade 3 Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Lymphoepithelial Cyst

description: A benign, unilocular or multilocular cyst that arises from the head and neck, usually the oral cavity, parotid gland, angle of mandible, and lateral neck. It is lined by epithelial cells and has a dense lymphoid stroma. It has been described in immunocompetent individuals and HIV-positive patients.


name: Grade 1 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 2 Neck NOS Intra-Operative Injury, CTCAE


Nodular Neoplasm

description: A benign or malignant neoplasm characterized by the formation of nodules by the proliferating neoplastic cells.


Grade 2 Psychosis, CTCAE

description: Moderate psychotic symptoms (e.g., disorganized speech; impaired reality testing)


name: Stage IV Adult Diffuse Mixed Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Grade 3 Hot Flashes, CTCAE

description: Severe symptoms; limiting self care ADL


name: Metastatic Childhood Malignant Bone Neoplasm by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Acute Myeloid Leukemia, Myelodysplasia-Related

description: Acute myeloid leukemia, myelodysplasia-related that is resistant to treatment.


Sharp Chest Pain

description: The sensation of chest pain described as a stabbing feeling.


Pharyngeal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures).


Bilateral Thalamic Glioma

description: A glioma affecting both sides of the thalamus.


Grade 2 Nipple Deformity, CTCAE

description: Symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex


Solid Angioleiomyoma

description: A morphologic variant of angioleiomyoma characterized by the presence of numerous small, slit-like vascular channels.


Other Neurology, CTCAE

description: A finding indicating the presence of multiple pouches, usually in the colonic or gastric wall.


name: Childhood Pancreatic Acinar Cell Cystadenocarcinoma

description: An acinar cell cystadenocarcinoma that arises from the pancreas during childhood.


name: Hematologic Neoplasm with Germline Predisposition Associated with a Constitutional Platelet Disorder

description: Hematologic neoplasms associated with germline mutations and familial platelet disorders.


Conjunctivitis Infective, CTCAE

description: A disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.


Primary Neoplasm

description: A tumor at the original site of origin.


name: Pathologic Stage IIB Cutaneous Melanoma AJCC v8

description: Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0). T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Grade 2 Hyperparathyroidism, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Adult Acute Promyelocytic Leukemia with PML-RARA

description: An acute promyelocytic leukemia with t(15;17)(q24.1;q21.2); PML-RARA occurring in adults.


Carcinoma of urinary bladder, invasive

description: A carcinoma that arises from the bladder mucosa and invades the bladder wall.


Grade 1 Hypomagnesemia, CTCAE

description: <LLN-1.2 mg/dL; <LLN-0.5 mmol/L


name: Grade 4 Upper Extremity Vein Intra-Operative Injury, CTCAE


Grade 1 Hyperhidrosis, CTCAE

description: Limited to one site (palms, soles, or axillae); self care interventions


Infiltrating Cervical Carcinoma

description: A carcinoma that arises from the cervix and invades into the stromal tissue.


Hyperparathyroidism, CTCAE

description: A disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).


Intraoperative injury

description: Trauma to the body occurring during a surgical intervention.


name: Invasive Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: An invasive urothelial carcinoma characterized by the presence of clear (glycogen-rich) cells.


Proximal Urethral Carcinoma

description: A carcinoma that arises from the proximal part of the urethra.


Foveolar hyperplasia

description: A hyperplasia of the gastric foveolar epithelium.


name: Diffuse Low Grade Glioma, FGFR1 Tyrosine Kinase Domain-Duplicated

description: Diffuse low-grade glioma characterized by internal tandem duplications of the sequences in the FGFR1 gene encoding the tyrosine kinase domain.


name: Grade 5 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Portal Hypertension, CTCAE

description: Reversal/retrograde portal vein flow; associated with varices and/or ascites


name: Endometrial Endometrioid Adenocarcinoma with Metaplastic Changes


name: Hepatocyte Nuclear Factor 1-Alpha Hyperinsulinism

description: Hyperinsulinism due to mutation(s) in the gene HNF1A, encoding the transcription factor hepatocyte nuclear factor 1-alpha. This condition may progress to diabetes later in life.


Injury of brachial plexus

description: Damage to the nerves in the brachial plexus network. These nerves originate in the spinal column and innervate the shoulder, arm and hand. Often, damage is sustained from overstretching or motor vehicle accidents.


name: Localized Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor confined to area of origin including abdominal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 3 Pelvis NOS Intra-Operative Injury, CTCAE


name: Grade 4 Fallopian Tube Obstruction, CTCAE


name: Grade 1 Gallbladder Intra-Operative Injury, CTCAE


name: Alanine Aminotransferase Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.


name: Grade 5 Female Genital Tract Fistula, CTCAE


Antepartum Obstetric Air Embolism

description: Presence of a large air bubble in the maternal vascular system which originated from a distant site during the antepartum period.


name: Grade 5 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ischemia Cerebrovascular, CTCAE

description: A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.


Paroxysmal Atrial Tachycardia, CTCAE

description: A disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria.


name: Grade 2 Laryngeal Nerve Dysfunction, CTCAE


Examination phobia

description: An overwhelming, irrational, and persistent fear of taking and failing tests.


Borderline Uterine Ligament Neoplasm

description: A rare borderline tumor that arises from the broad or other uterine ligaments. The majority of the reported cases are serous cystic tumors.


Progesterone Receptor Status

description: Indicates the progesterone receptor level measured in a primary tumor or in metastases. (>=10 is positive if measured in fmols/mg cytosol protein; Otherwise use institutional standards)


Adult L1 Acute Lymphoblastic Leukemia

description: L1 acute lymphoblastic leukemia that occurs during adulthood.


Mucolipidosis Type IIIA

description: A lysosomal storage disease characterized by multiple bone formation abnormalities, progressive joint stiffness, developmental abnormalities, hearing loss, hepatosplenomegaly, increased acne, enlarged tongue, and cornea clouding due to accumulation of lipid substances.


name: Posterior Fossa Ependymoma, Not Elsewhere Classified

description: A circumscribed ependymoma that arises in the posterior fossa in which molecular analysis for DNA methylation profiling cannot assign a molecular group.


Grade 2 Hyponatremia, CTCAE

description: 125-129 mmol/L and asymptomatic


Non-Neoplastic Stomach Disorder

description: A non-neoplastic disorder that affects the stomach. Representative examples include gastritis and ulcer.


name: Grade 2 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Scrotal Infection, CTCAE

description: A disorder characterized by an infectious process involving the scrotum.


name: Grade 3 Lower Extremity Intra-Operative Injury, CTCAE


Unresectable Merkel Cell Carcinoma

description: Merkel cell carcinoma that is not amenable to surgical resection.


Papulopustular Rash

description: Skin eruption consisting of papules and pustules, most often appearing in the face, scalp, and upper trunk.  It is usually caused by corticosteroids or epidermal growth factor receptor inhibitors.


name: Grade 4 Intraoperative Ocular Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 5 Laryngospasm, CTCAE

description: Death


Poorly Differentiated Angiosarcoma

description: An angiosarcoma characterized by the presence of significant cytologic atypia, necrosis and high mitotic activity.


name: Grade 5 Herpes Simplex Reactivation, CTCAE

description: Death


name: Genitourinary tract gonococcal infection

description: A genitourinary infection that is caused by Neisseria gonorrhoeae.


name: Grade 2 Urethral Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Adult Pineal Gland Astrocytoma

description: A pineal gland astrocytoma that occurs during adulthood.


Ulcer of nipple

description: Ulcer that develops in the nipple.  Causes include trauma and Paget disease.


Acquired Unilateral Cataract

description: A cataract in one eye that results from the aging process, an injury, or as a manifestation of a systemic disorder.


Grade 3 Neonatal Pneumothorax, AE

description: An adverse event in a newborn characterized by radiological evidence of pneumothorax; with clinical signs; major care change required (e.g. chest drainage).


Grade 4 Gastric Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Urethral Pain

description: A painful sensation in the urethra.


Azoospermia, CTCAE

description: A disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen.


name: Grade 3 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


High Grade Appendix Mucinous Neoplasm

description: A rare appendix mucinous neoplasm characterized by the presence of neoplastic epithelial cells with high grade features.


name: Non-Malignant Pericardial Effusion, CTCAE


Stage IB3 Cervical Cancer AJCC v9

description: Stage IB3 includes: T1b3, N0, M0. T1b3: Tumor measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 2 Dysgeusia, CTCAE

description: Altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste


Bilateral Malignant Neoplasm

description: A malignant neoplasm that affects both sides of an organ in a simultaneous or non-simultaneous manner.


End stage cardiac failure

description: The terminal phase of heart failure in patients. The disease course may have progressed despite intervention and may be characterized by dyspnea, fatigue, and weakness.


Thoracic myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the thoracic region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


name: Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Uterine Corpus Cancer AJCC v6

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0).  T2: Tumor invades cervix but does not extend beyond uterus.  T2a: Tumor limited to the glandular epithelium of the endocervix.  There is no evidence of connective tissue stromal invasion.  T2b: Invasion of the stromal connective tissue of the cervix.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 4 Vitreous Hemorrhage, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


Refractory Glioblastoma

description: A glioblastoma that is resistant to treatment.


Grade 1 Vital Capacity Abnormal, CTCAE

description: 90-75% of predicted value


Prostate Cancer by AJCC v6 Stage

description: A term that refers to the staging of prostate carcinoma according to the American Joint Committee on Cancer, 6th edition.


name: Grade 2 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Benign Liver Epithelial Neoplasm

description: A neoplasm that arises from the hepatocytes or intrahepatic bile duct epithelial cells and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hepatocellular adenoma and bile duct adenoma.


name: Grade 5 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Metastatic Endometrial Serous Adenocarcinoma

description: An endometrial serous adenocarcinoma that has spread to other anatomic sites.


name: Abdominal and gastrointestinal infections

description: An infection that affects the gastrointestinal system and the abdomen.


name: Metastatic Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Distant metastases present at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Recurrent Uterine Corpus Cancer

description: The reemergence of uterine corpus cancer after a period of remission.


Pulmonary Valve Disease, CTCAE

description: A disorder characterized by a defect in pulmonary valve function or structure.


Grade 4 Soft Tissue Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Locally Recurrent Anal Canal Squamous Cell Carcinoma

description: The reemergence of anal canal squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Lymphangioma circumscriptum

description: A localized lymphangioma characterized by microcystic changes.


Hyperglucagonemia

description: Abnormally high levels of glucagon in the blood, which may manifest as hyperglycemia and/or necrolytic migratory erythema.


ADAMTS13 Activity Less than 10 Percent

description: A finding indicating that the ADAMTS13 activity expressed by a sample is less than 10 percent of the expected value.


Grade 1 Neonatal Hypertension, AE

description: An adverse event in a newborn characterized by systolic or diastolic blood pressure above the 90th percentile but below the 95th percentile; self-limiting.


Grade 3 Nephrotic Syndrome, CTCAE

description: Not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


name: Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Edema Cerebral, CTCAE

description: New onset; worsening from baseline


name: Grade 5 Cranial Nerve XI Neuropathy, CTCAE


name: Glandular intraepithelial neoplasia, low grade


name: Grade 1 Carbon Monoxide Diffusion Capacity, CTCAE


Grade 2 Breast Atrophy, CTCAE

description: Moderate asymmetry; moderate atrophy


name: Grade 2 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Malignant Mesothelioma

description: Malignant mesothelioma that is resistant to treatment.


anaplastic carcinoma of ureter

description: Undifferentiated carcinoma that affects the ureter.


name: Grade 3 Lingual Nerve Intra-Operative Injury, CTCAE


Grade 3 Fever, CTCAE

description: >40.0 degrees C (>104.0 degrees F) for <=24 hrs


Defective Mu Heavy Chain Present

description: An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain mu have been detected in a sample.


Grade 4 Urostomy Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Feminization Acquired, CTCAE

description: A disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors.


name: Abdominal Neoplasm, Excluding Pancreas Neoplasm

description: A  finding of a neoplastic disease in the abdominal cavity, excluding pancreatic neoplastic disease.


name: Atypical Small Acinar Proliferation of the Prostate Gland

description: Focal proliferation of small acinar glandular cells in the prostate gland with cytologic changes ranging from atypia to highly suggestive of malignancy.


name: Grade 4 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Pharynx Intra-Operative Injury, CTCAE


Stage IV Gastric Cancer AJCC v6

description: Stage IV includes: (T4, N1-3, M0); (T1-3, N3, M0); (Any T, Any N, M1).  M1:Distant metastasis. (AJCC 6th ed.)


Grade 3 Paronychia, CTCAE

description: Operative intervention indicated; IV antibiotics indicated; limiting self care ADL


name: Grade 1 Hypoglossal Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Herpes Simplex Reactivation, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


name: Grade 3 Scleral Necrosis and Melt, CTCAE


name: Invasive Giant Cell Urothelial Carcinoma

description: An invasive urothelial carcinoma characterized by the presence of giant cells.


name: Grade 4 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Stomach Stricture or Stenosis, CTCAE


name: Probable Adverse Event Relationship to Product or Procedure

description: Probable adverse event relationship to study product or procedure is defined when there is a clear-cut temporal association between product or procedure administration and adverse event, and a potential alternative etiology of the event is not apparent.


name: Prostate Carcinoma Metastatic in the Pelvic Cavity

description: A carcinoma that arises from the prostate gland and has spread to the pelvic cavity.


Recurrent Oligodendroglioma

description: The reemergence of oligodendroglioma after a period of remission.


name: Stage IV Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Hematogenous metastases or spread beyond abdomen at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 4 Neonatal Respiratory Insufficiency, AE

description: A respiratory insufficiency adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; requiring urgent care change (e.g. urgent intubation).


Cesarean wound disruption

description: Asymptomatic separation of the uterine wall, usually at the site of a prior uterine scar, that does not include the overlying serosa.


Male Reproductive System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the male reproductive system. Representative examples include prostate carcinoma and penile carcinoma.


Affective Disorders, Psychotic

description: The manifestation of psychotic symptoms, such as hallucinations or delusions, in the presence of a mood disorder.


Holorachischisis

description: A form of the neural tube defect spina bifida in which the entire spinal column is open.


name: Diffuse Pediatric-Type High Grade Glioma RTK2

description: An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 2 (RTK2) alterations.


name: Stage IV Intermediate Grade Adult Non-Hodgkin's Lymphoma


Exhaustion

description: A state in which an entity is functionally inept and incapable of exhibiting the usual array of activities.


Grade 5 Guillain-Barre Syndrome, CTCAE

description: Death


name: Lugano Classification Stage I Adult Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Stage III Cervical Cancer AJCC v8

description: Stage III includes: T3, Any N, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


Laboratory Test Toxicity

description: A laboratory test designed to quantify or qualify the poisonous nature of a sample.


Grade 2 Pneumothorax, CTCAE

description: Symptomatic; intervention indicated


name: Squamous cell carcinoma, large cell, nonkeratinizing

description: A squamous cell carcinoma composed of large atypical cells, without morphologic evidence of keratin production.


Stage II Esophageal Cancer

description: Stage II includes: IIA: (T2, N0, M0); (T3, N0, M0) and IIB: (TI, NI, M0); (T2, NI, M0).  TI: Tumor invades lamina propria or submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) -2003


Conjunctival Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the conjunctiva. This category includes conjunctival nevus, conjunctival melanocytic intraepithelial lesions, and conjunctival melanoma.


Conjunctivitis, CTCAE

description: A disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.


name: Benign Lacrimal Drainage System Neoplasm

description: A neoplasm that arises from the lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Hepatobiliary Inflammation

description: An inflammatory process affecting the liver, bile ducts and gallbladder.


Grade 3 Brachial Plexopathy, CTCAE

description: Severe symptoms; limiting self care ADL


Grade 2 Urostomy Stenosis, CTCAE

description: Symptomatic but no hydronephrosis, sepsis, or renal dysfunction; dilation or endoscopic repair or stent placement indicated


name: Gastroesophageal Junction Adenocarcinoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of gastroesophageal junction adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Grade 4 Non-Malignant Pleural Effusion, CTCAE


name: Grade 5 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

description: Death


Diffuse Midline Glioma, EGFR-Mutant

description: A diffuse midline glioma, H3 K27-altered, characterized by the presence of EGFR gene mutation.


Grade 5 Erythema Multiforme, CTCAE

description: Death


name: Dyskeratosis Congenita, Autosomal Recessive 3

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the WRAP53 gene, encoding telomerase Cajal body protein 1.


name: Grade 2 Phrenic Nerve Dysfunction, CTCAE


Stage IIIC2 Cervical Cancer AJCC v9

description: Stage IIIC2 includes: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 9th Ed.)


Endobronchial Nodule

description: A nodule entirely contained within a bronchus; it may obstruct the airway, but does not breach the bronchial wall.


Breast Adenohibernoma

description: A breast hamartoma characterized by the presence of brown fat that contains entrapped glands.


name: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

description: An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The pre-B lymphoblasts contain cytoplasmic immunoglobulin.


Grade 5 Ovarian Hemorrhage, CTCAE

description: Death


Grade 1 Burn, CTCAE

description: Minimal symptoms; intervention not indicated


name: Grade 4 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stage IIA Prostate Cancer AJCC v8

description: Stage IIA includes: (cT1a-c, cT2a, N0, M0, PSA equal or more than 10 and less than 20, Grade Group 1); (cT2b-c, N0, M0, PSA less than 20, Grade Group 1). cT1a: Prostate cancer in which the tumor is an incidental histologic finding in 5% or less of tissue resected. cT1b: Prostate cancer in which the tumor is an incidental histologic finding in more than 5% of tissue resected. cT1c: Prostate cancer in which the tumor is identified by needle biopsy found in one or both sides, but not palpable. cT2a: Prostate cancer in which the tumor involves one-half of one side or less. cT2b: Prostate cancer in which the tumor involves more than one-half of one side but not both sides. cT2c: Prostate cancer in which the tumor involves both sides. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. (AJCC 8th ed.)


Anal Cancer by AJCC v8 Stage

description: A term that refers to the staging of anal cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all carcinomas arising in the anal canal, including carcinomas that arise within anorectal fistulas and those arising in the perianal area (anal margin). High-grade neuroendocrine carcinomas (small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma) are staged using this system. There is no AJCC staging system for anal mucosal melanomas and anal well-differentiated neuroendocrine tumors. (from AJCC 8th Ed.)


name: Well Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of well differentiated malignant glandular epithelial components.


Primary Cutaneous Hodgkin Lymphoma

description: Hodgkin lymphoma primarily involving the skin.  This diagnosis can only be made when there is no evidence of Hodgkin lymphoma in the lymph nodes or other anatomic sites.  Patients usually present with papules or nodular lesions.  Morphologically, primary cutaneous Hodgkin lymphoma may resemble lymphomatoid papulosis or anaplastic large cell lymphoma.  Immunohistochemical tissue evaluation is essential in establishing the diagnosis.


name: Grade 5 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Stroke, CTCAE

description: A disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.


Grade 5 Pancreatitis, CTCAE

description: Death


name: Grade 3 Blood Antidiuretic Hormone Abnormal, CTCAE

description: Hospitalization indicated


name: Human Papillomavirus-Related Cervical Adenocarcinoma

description: A cervical adenocarcinoma associated with the presence of human papillomavirus infection.


Mucocele of gallbladder

description: The enlargement of the gallbladder secondary to prolonged obstruction of the cystic duct.


Grade 1 Erectile Dysfunction, CTCAE

description: Decrease in erectile function (frequency or rigidity of erections) but intervention not indicated (e.g., medication or use of mechanical device, penile pump)


name: Grade 4 Small Bowel NOS Intra-Operative Injury, CTCAE


Biliary Tract Carcinoma

description: A carcinoma arising from the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, or gallbladder.


Pancreatic Teratoma

description: A teratoma that arises from the pancreas.


Tobacco Induced Hyperparakeratosis

description: Hyperparakeratosis of the oral mucosa caused by chronic tobacco use.  It manifests as oral leukoplakia.


name: Locally Advanced Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 2 Sinusoidal Obstruction Syndrome, CTCAE

description: Blood bilirubin 2-5 mg/dL; minor interventions required (i.e., blood product, diuretic, oxygen)


name: Grade 2 Prolapse of Gastrointestinal Stoma, CTCAE


name: Grade 2 Cardiac Ischemia or Infarction, CTCAE


name: Grade 2 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Upper Gastrointestinal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 4 Small Intestinal Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: COL1A1 Associated Connective Tissue Disorder

description: A group of connective tissue disorder caused by mutations in the COL1A1 gene mapped to chromosome 17q21. It includes the Ehlers-Danlos syndrome, osteogenesis imperfecta, and osteoporosis.


Stage 0 Esophageal Cancer AJCC v6

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.)


name: Grade 1 Fallopian Tube Anastomotic Leak, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Splenic Infection

description: An infectious process affecting the spleen. Predisposing factors include immunosuppression, diabetes mellitus, and sickle cell anemia. Infectious agents include bacteria (e.g., staphylococcus and streptococcus) and fungi.


name: Grade 2 CNS Cerebrovascular Ischemia, CTCAE


Grade 5 Encephalitis Infection, CTCAE

description: Death


name: High Grade Corneal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the corneal epithelium.


description: An endometrial carcinoma that has a documented response to platinum-based chemotherapy.


name: Grade 2 Kidney Intra-Operative Injury, CTCAE


name: Grade 2 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


Skin Verrucous Carcinoma

description: A verrucous carcinoma that arises from the skin. It usually affects the palms, soles, and distal digits.


Glucose-6-Phosphatase 3 Deficiency

description: An autosomal recessive inherited disorder caused by mutations in the G6PC3 gene. It is characterized by the absence or presence of very low levels of glucose-6-phosphatase 3. Patients may develop severe congenital neutropenia.


name: Conventional Follicular Dendritic Cell Sarcoma

description: Follicular dendritic cell sarcoma that is not associated with Epstein-Barr virus.


name: Grade 4 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Breast fibroadenolipoma

description: A benign, circumscribed and usually encapsulated lesion of the breast.  It contains all the components of the breast tissue.


name: Unresectable Primary Central Nervous System Neoplasm

description: A primary central nervous system neoplasm that is not amenable to surgical resection.


Prostate Intraductal Carcinoma

description: An intra-acinar and/or intraductal neoplastic epithelial proliferation in the prostate gland that has some features of high-grade prostatic intraepithelial neoplasia but exhibits much greater architectural and/or cytological atypia, typically associated with high-grade, high-stage prostate carcinoma. (WHO 2016)


Resectable Osteosarcoma

description: Osteosarcoma that is amenable to surgical resection.


name: Ionizing Radiation-Related Malignant Neoplasm

description: A malignant neoplasm arising in an anatomic site exposed to ionizing radiation.


name: Grade 5 Injury To Inferior Vena Cava, CTCAE

description: Death


Dry Skin, CTCAE

description: A disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture.


Fascial fibrosarcoma

description: A malignant fibroblastic neoplasm arising from the fascial connective tissue.


name: Transplant-Related Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that arises in a patient with a history of organ transplantation.


name: Serum Prostate Specific Antigen Increased


name: Grade 5 Local Complication of Device and Prosthesis, CTCAE


Vaginal Basaloid Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of nests of malignant basaloid squamous cells with scant amounts of cytoplasm.


Grade 2 Phlebitis, CTCAE

description: Present


name: Ventral Hernia with Obstruction without Mention of Gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, which results in obstruction, without mention of necrosis of the herniated contents.


name: Autosomal Dominant Neurohypophyseal Diabetes Insipidus

description: An autosomal dominant form of diabetes insipidus caused by mutation(s) in the AVP gene encoding arginine vasopressin.


name: Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Vaginal Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Advanced Bone Sarcoma

description: A bone sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Lipid-Rich Urothelial Carcinoma

description: Lipid-rich urothelial carcinoma that has spread to another anatomic site.


Stage IV Fallopian Tube Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine. (from AJCC 8th Ed.)


name: Adverse Event Associated with the Ear and Auditory System


Grade 3 Ileal Fistula, CTCAE

description: Invasive intervention indicated


Decreased PARP Enzyme Activity

description: A finding indicating that a sample is expressing lower levels of poly [ADP-ribose] polymerase enzyme activity than that expressed by a reference or comparative sample.


name: Grade 3 Intraoperative Splenic Injury, CTCAE

description: Resection or reconstruction of injured organ/structure indicated; limiting self care ADL


name: Recurrent Vulvar Squamous Cell Carcinoma

description: The reemergence of vulvar squamous cell carcinoma after a period of remission.


name: Grade 2 Lymphedema-Related Fibrosis, CTCAE


name: Grade 4 Ophthalmoplegia and Diplopia, CTCAE


Metastatic Anal Carcinoma

description: Anal carcinoma that has spread from its primary site to another anatomic site.


name: Undifferentiated Fallopian Tube Carcinoma

description: An invasive carcinoma arising from the fallopian tube. It is characterized by the presence of a diffuse malignant infiltrate that is composed of epithelial cells without evidence of glandular or squamous differentiation.


name: Grade 2 Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Transfusion dependent thalassaemia

description: Thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


name: Metastatic malignant neoplasm to nervous system

description: The spread of a malignant neoplasm to the nervous system.  This may be from a primary nervous system malignant neoplasm, or from a malignant neoplasm at a distant site.


name: Grade 3 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage III Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: large cell neuroendocrine carcinoma of anal canal

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal.  It is characterized by the presence of malignant large cells.


Hilar Mass

description: An abnormal growth located in the hilum of the lung.


Appendix Mucinous Neoplasm

description: An appendiceal neoplasm characterized by mucinous epithelial proliferation with extracellular mucin and pushing tumour margins. (WHO 2019)


name: Grade 5 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Primary Immune Regulatory Disorder

description: A group of immune diseases characterized predominantly by immune dysregulation leading to organ-specific autoimmunity, excessive inflammation, and non-malignant lymphoproliferation. Unlike classical primary immunodeficiencies, susceptibility to infections is typically less prominent in these disorders.


name: acute myelomonocytic leukemia in relapse

description: The reemergence of acute myelomonocytic leukemia after a period of remission.


name: Bile Duct Intraductal Papillary Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of moderate epithelial atypia.


Grade 4 Tumor Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Stage IVA Fallopian Tube Cancer AJCC v8

description: Stage IVA includes: Any T, Any N, M1a. M1a: Fallopian tube cancer with pleural effusion with positive cytology. (from AJCC 8th Ed.)


Retinoma

description: A rare, unilateral or bilateral benign neoplasm that arises from the retina. There is an increased risk of malignant transformation to retinoblastoma; therefore, patients with a diagnosis of retinocytoma should be closely observed.


Intra-Abdominal Lymphangioma

description: A lymphangioma arising from the organs of the abdominal cavity.


name: Grade 5 Infusion Site Extravasation, CTCAE

description: Death


Medical Device Exposure

description: Exposure of an individual to a medical device.


name: Grade 3 White Blood Cell Decreased, CTCAE

description: <2000-1000/mm3; <2.0-1.0 x 10e9/L


name: Extrahepatic Bile Duct Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


name: Flashing Lights and Floaters in Vision, CTCAE


name: Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Skin

description: An epithelioid malignant peripheral nerve sheath tumor that arises from the skin.


Refractory Brain Neoplasm

description: Brain neoplasm that is resistant to treatment.


name: Grade 2 Psychiatric Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 4 Upper Extremity Intra-Operative Injury, CTCAE


name: Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Extracutaneous Merkel Cell Carcinoma

description: A rare Merkel cell carcinoma that arises from extracutaneous sites, including the oral cavity, salivary glands, breast, vulva, and vaginal wall.


name: Stage I Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 1 Electrocardiogram T Wave Abnormal, CTCAE

description: T wave flattening


Adenocarcinoma in situ in a polyp

description: An adenocarcinoma arising in a polyp.


Injury of ovary

description: Trauma to an ovary.


Grade 5 Jejunal Stenosis, CTCAE

description: Death


name: Grade 4 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Cranial Nerve VI Neuropathy, CTCAE


Grade 3 Stomal Ulcer, CTCAE

description: Severe symptoms; elective operative intervention indicated


name: Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Corneal Infection, CTCAE

description: Death


name: Death Not Associated with More Specific Term, CTCAE


name: Grade 3 Cranial Nerve IX Neuropathy, CTCAE


Skin Hypopigmentation, CTCAE

description: A disorder characterized by loss of skin pigment (e.g., vitiligo).


Appendix Tubular Adenoma

description: An adenoma arising from the appendix.  It is characterized by the presence of tubular epithelial structures and it is associated with dysplasia.


name: Refractory Childhood Acute Myeloid Leukemia

description: Childhood acute myeloid leukemia that does not respond to treatment.


name: Grade 2 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Acute Myeloid Leukemia with t(11;19)(q23.3;p13.3); KMT2A-MLLT1

description: An acute myeloid leukemia associated with t(11;19)(q23.3;p13.3) resulting in KMT2A-MLLT1 gene fusion. It usually affects infants and children.


Annoying Pain

description: A sensation of discomfort or distress that is bothersome and irritating.


name: Grade 3 Right Ventricular Dysfunction, CTCAE

description: Severe symptoms, associated with hypoxia, right heart failure; oxygen indicated


name: Grade 2 Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Intraoperative Splenic Injury

description: Damage to the spleen during a surgical procedure.


Indolent T-Lymphoblastic Proliferation

description: A non-neoplastic T-cell lymphoproliferation that may mimic T-lymphoblastic lymphoma. It usually involves the lymphoid tissues of the upper aerodigestive tract. It recurs locally, but systemic dissemination is rare.