Lung Infection, CTCAE

description: A disorder characterized by an infectious process involving the lungs, including pneumonia.


Grade 1 Perineum Pain, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Grade 3 Serum Glutamic Pyruvic Transaminase, CTCAE


name: histiocytic sarcoma of central nervous system

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Rare involvement of the central nervous system by histiocytic sarcoma.


Grade 2 Rectal Stenosis, CTCAE

description: Symptomatic; altered GI function


name: Grade 5 Hepatobiliary Disorders - Other, Specify, CTCAE

description: Death


name: Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Grade 3 Somnolence, CTCAE

description: Obtundation or stupor


name: Liver Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pancreatic carcinoma non-resectable

description: Carcinoma of the pancreas that is not amenable to surgical removal.


Grade 2 Flatulence, CTCAE

description: Moderate; persistent; psychosocial sequelae


name: Metastatic Malignant Neoplasm in the Lacrimal Drainage System

description: A malignant neoplasm that has spread from its original site of growth to the lacrimal drainage system.


Metachronous Malignant Neoplasm

description: A malignant tumor that arises at a site separate from another, primary malignant tumor in the same anatomic system.  It is not clear if metachronous malignant neoplasms represent new primary tumors or metastatic disease.  Examples include metachronous osteosarcoma of the bones that develops in patients with known primary bone osteosarcoma, and metachronous Wilms' tumor that affects the opposite kidney in patients with a history of Wilms' tumor.


name: Childhood Benign Connective and Soft Tissue Neoplasm

description: A childhood neoplasm that arises from connective and soft tissue and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Locally Advanced Vulvar Carcinoma

description: Vulvar carcinoma that has spread to nearby tissues or lymph nodes.


Resectable Glioma

description: A glioma that is amenable to surgical resection.


Vulvar Germ Cell Tumor

description: A rare germ cell tumor that arises from the vulva.


Subgaleal Hemorrhage Related to Birth

description: Bleeding in the potential space between the skull periosteum and the scalp galea aponeurosis of a newborn infant due to shearing forces on the tentorium and deep venous system during labor and delivery.


High Grade Fever

description: Body temperature of 104 degrees Fahrenheit (40 degrees Celsius) or higher.


Neuroendocrine breast tumor

description: A well-differentiated neuroendocrine neoplasm that arises from the breast. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


Grade 1 Hemoglobinuria, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Atypical Gastric Lymphoid Hyperplasia

description: An atypical lymphoid hyperplasia involving the gastric mucosa.


Childhood Low Grade Glioma

description: A low-grade glioma that occurs during childhood.


name: Grade 5 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 5 Bronchial Obstruction, CTCAE

description: Death


Grade 2 Dry Skin, CTCAE

description: Covering 10-30% BSA and associated with erythema or pruritus; limiting instrumental ADL


name: Grade 4 Hepatobiliary Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Unilateral Anophthalmos

description: A rare congenital abnormality characterized by the complete absence of ocular tissue in one orbit.


Childhood Overweight

description: A condition in which a child's body mass index (BMI) falls at or above the 85th percentile, but below the 95th percentile based on the normative values for the age and sex of the reference population.


name: Grade 1 Metabolic or Respiratory Acidosis, CTCAE


Infant Irritability, AE

description: An adverse event in a newborn characterized by crying easily and difficulty consoling.


name: Stage IA Esophageal Adenocarcinoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Grade 1 Small Bowel Perforation NOS, CTCAE


name: Grade 2 Sinus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Stage IV Appendix Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Grade 1 Vaccination Complication, CTCAE

description: Mild pain; erythema 2.5-5cm; induration/swelling 2.5-5cm; does not interfere with activity


name: Grade 5 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Vasogenic Edema

description: Edema that is characterized by increased permeability of capillary endothelial cells.


name: Grade 2 Alanine Aminotransferase Increased, CTCAE

description: >3.0-5.0 x ULN if baseline was normal; >3.0-5.0 x baseline if baseline was abnormal


Metastatic small cell carcinoma

description: A small cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


name: Grade 2 Hepatic Vein Intra-Operative Injury, CTCAE


Stevens-Johnson Syndrome, CTCAE

description: A disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.


name: Grade 4 Cranial Nerve IX Neuropathy, CTCAE


Edema Limbs, CTCAE

description: A disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities.


name: Grade 3 Hepatic Vein Intra-Operative Injury, CTCAE


name: Grade 2 Jejunum Intra-Operative Injury, CTCAE


Granulosa cell-theca cell tumor

description: A general term used to describe sex cord-stromal tumors characterized by the presence of granulosa cells in a thecomatous/fibrothecomatous background.


name: Grade 1 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Platinum-Resistant Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that progresses between one and six months of completing platinum therapy.


Dermal Melanoma

description: A melanoma that is confined to the dermis and subcutaneous tissue without involvement of the epidermis.


name: Grade 2 Retinal Vascular Disorder, CTCAE

description: Retinal vascular disorder without neovascularization


name: Grade 4 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Pharyngeal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Eye Infection, CTCAE

description: A disorder characterized by an infectious process involving the eye.


name: Grade 3 Fallopian Tube Intra-Operative Injury, CTCAE


name: Gastroesophageal Junction Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant large cells.


name: Pancreatic Poorly Differentiated Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma characterized by the presence of small and irregular malignant glandular structures, solid sheets of malignant cells, and single malignant cells.


name: T-Cell Large Granular Lymphocyte Leukemia, Common Variant

description: T-cell large granular lymphocyte leukemia defined by the presence of CD3-positive, CD8-positive, and T-cell receptor alpha-beta-positive cytotoxic T-cells.


name: Grade 4 Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Meningitis, CTCAE

description: A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord.


name: Grade 3 Breast Intra-Operative Injury, CTCAE


Gastric Cancer by AJCC v7 Stage

description: A term that refers to the staging of gastric carcinoma according to the American Joint Committee on Cancer, 7th edition.


Lymphocele, CTCAE

description: A disorder characterized by a cystic lesion containing lymph.


Radiculoneuropathy

description: Spontaneous degeneration of the spinal cord and peripheral nerves characterized by myelin sheath vacuolation, Wallerian degeneration and intramyelinic space infiltration by macrophages.


name: Unspecified deformity of forearm, excluding fingers

description: Any anatomic abnormality of the arm located between the elbow and the wrist.


name: Grade 4 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Acute Myeloid Leukemia with del(7q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 7 [del(7q)].


name: Muscular Dystrophy Secondary to Mitochondrial Disorder

description: A muscular dystrophy that was caused by a primary mitochondrial disorder.


Locally Advanced Adenocarcinoma

description: Adenocarcinoma that has spread to nearby tissues or lymph nodes.


name: Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Gallbladder Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Radiation Overdose

description: A higher than intended cumulative dose of radiation to a single field.


name: External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Intraoperative Neurological Injury

description: Damage to any part of the nervous system during a surgical procedure.


name: Grade 3 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


Grade 2 Hyperthyroidism, CTCAE

description: Symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL


Intermediate Bone Neoplasm

description: A locally aggressive or rarely metastasizing neoplasm that arises from the bone.


Grade 4 Injury To Carotid Artery, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Amnesia, CTCAE

description: Mild; transient memory loss


name: Grade 5 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Criminal injury

description: Trauma resulting from illegal activity.


name: Unresectable Peritoneal Malignant Mesothelioma

description: Peritoneal malignant mesothelioma that is not amenable to surgical resection.


name: Grade 1 Anus Stricture or Stenosis, CTCAE


Fuchs' adenoma

description: A benign proliferation of the pars plicata epithelium of the ciliary body. It is associated with aging..


Grade 2 Heart Failure, CTCAE

description: Symptoms with moderate activity or exertion


name: Grade 2 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Adverse Event Associated with the Hepatobiliary System and Pancreas


name: Grade 2 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Embolism, Amniotic Fluid

description: Acute hypotension or cardiac arrest, acute hypoxia or coagulopathy in the absence of any other potential explanation related to the presence of amniotic fluid or the fetal debris within the maternal vascular system during the antepartum or intrapartum period.


Grade 5 Enterocolitis Infectious, CTCAE

description: Death


name: Hematologic Neoplasm with Germline Predisposition

description: A term that refers to myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, and acute myeloid leukemias that are associated with germline mutations and are familial.


name: Grade 3 Intraoperative Endocrine Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Stage IIIA Vulvar Cancer AJCC v7

description: Stage IIIA includes: (T1/T2, N1a/N1b, M0); T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


Malignant Testicular Sertoli Cell Tumor

description: A Sertoli cell tumor that arises from the testis and is characterized by nuclear pleomorphism, increased mitotic activity and necrotic changes.  Metastases may be present at diagnosis.


Grade 2 Laryngeal Stenosis, CTCAE

description: Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


name: Grade 4 External Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Malignant Germ Cell Tumor

description: The reemergence of a malignant germ cell tumor after a period of remission.


Grade 3 Jejunal Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


name: Injury, Poisoning and Procedural Complications, CTCAE


Laryngeal Mucositis, CTCAE

description: A disorder characterized by ulceration or inflammation involving the mucous membrane of the larynx.


Congenital Platelets Abnormality

description: A group of rare inherited platelet disorders that involve abnormalities of platelet function or platelet production and that usually cause moderate to severe bleeding problems.


Grade 4 Hyperlipidemia, CTCAE

description: Life-threatening consequences


name: Grade 4 Eye NOS Intra-Operative Injury, CTCAE


name: Grade 4 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Defective Alpha Heavy Chain Present

description: An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain alpha have been detected in a sample.


name: Lugano Classification Childhood Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for childhood Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Hypotension, CTCAE

description: A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment.


Adult Angiosarcoma

description: An angiosarcoma occurring in the adult population.


Grade 2 Neuralgia, CTCAE

description: Moderate pain; limiting instrumental ADL


neoplasm of optic chiasm

description: A benign or malignant neoplasm that affects the optic chiasm.


Grade 1 Pyramidal Tract Syndrome, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Respiratory Tract Hemorrhage NOS, CTCAE


Abscess of pituitary

description: An inflammatory or infectious process in the pituitary gland characterized by a circumscribed, walled collection of purulent material.


Duodenal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the duodenum.


High Level of Hyaluronic Acid

description: A finding indicating high concentrations of hyaluronic acid in a sample.


name: Grade 1 Bronchus Intra-Operative Injury, CTCAE


Metastatic Conjunctival Melanoma

description: Conjunctival melanoma that has spread from its original site of growth to another anatomic site.


Grade 2 Infantile Apnea, AE

description: An adverse event in a newborn characterized by apnea responsive to stimulation or intermittent fraction of inspired oxygen (FiO2) increase.


Assault by sharp object

description: A physical attack with a pointed object.


name: Grade 4 Voice Changes and Dysarthria, CTCAE


name: Localized Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma of bone that occurs in adulthood and has not spread to other anatomic sites.


Grade 1 Wound Dehiscence, CTCAE

description: Incisional separation, intervention not indicated


name: Grade 4 Anus Intra-Operative Injury, CTCAE


Grade 5 Hemolysis, CTCAE

description: Death


Refractory Melanoma

description: Melanoma that does not respond to treatment.


name: Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Central Nervous System Paraganglioma

description: An extra-adrenal paraganglioma arising from the central nervous system.


Nuclear Cataract Grade 4

description: A stage of nuclear sclerotic cataract marked by severe yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Tuberculous abscess

description: An abscess resulting from infection by Mycobacterium tuberculosis.


description: An epithelioid hemangioendothelioma that has spread from its original site of growth to another anatomic site.


name: Grade 5 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Hypercalcemia, CTCAE

description: Death


Papillary carcinoma in situ

description: An epithelial neoplasm with a papillary growth pattern in which the malignant cells are confined to the epithelium, without evidence of invasion.


Glycemic Measurement Finding

description: A direct or indirect indication of the blood or plasma glucose level of a subject in order to examine their resting metabolism or analyze glycemic responses to dietary challenges or therapeutic interventions.


name: Grade 3 Larynx Obstruction and Stenosis, CTCAE


name: Grade 4 Surgical and Medical Procedures - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Unresectable Prostate Carcinoma

description: Prostate carcinoma that is not amenable to surgical resection.


name: Grade 4 Spleen Intra-Operative Injury, CTCAE


Grade 4 Rectal Necrosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Olfactory neurogenic tumor

description: A rare, benign (olfactory neurocytoma) or malignant (olfactory neuroblastoma) neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity.


name: Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma

description: Nodular sclerosis Hodgkin lymphoma in which at least 25% of the tumor nodules contain increased numbers of Reed-Sternberg cells.


Grade 5 Multi-Organ Failure, CTCAE

description: Death


name: Metastatic malignant neoplasm to lacrimal gland

description: A malignant neoplasm that has spread from its original site of growth to the lacrimal gland.


Malignant Fundus Neoplasm

description: A primary or metastatic malignant neoplasm that affects the gastric fundus.


name: Grade 2 Right Ventricular Dysfunction, CTCAE

description: Symptoms with moderate activity or exertion


Elevated Human Chorionic Gonadotropin

description: A finding indicating elevated concentrations of human chorionic gonadotropin in a sample.


name: Stage I Extragonadal Non-Seminomatous Germ Cell Tumor


name: Stage IIB Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIB includes: T2b, N0, M0.  T2b: Extension to other pelvic structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Grade 3 Small Intestinal Obstruction, CTCAE

description: Hospitalization indicated; invasive intervention indicated; limiting self care ADL


name: Polyostotic Langerhans cell histiocytosis

description: Langerhans cell histiocytosis presenting with multiple sites of involvement.


name: Stage III Acral Lentiginous Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Diencephalic Glioblastoma

description: A glioblastoma that occurs in the diencephalon.


Grade 5 Hypothyroidism, CTCAE

description: Death


Nightmare Disorder

description: A sleep disorder characterized by the repeated occurrence of frightening dreams which precipitate awakenings from sleep; on awakening, the individual becomes fully alert and oriented and has detailed recall of the nightmare, which usually involves imminent danger or extreme embarrassment to the individual.


Retinoblastoma, spontaneously regressed

description: An archaic term that refers to benign, non-progressive retinal lesions in patients with mutation of the RB1 gene.


name: Grade 4 Nasopharynx Intra-Operative Injury, CTCAE


Elevated CEA

description: A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CEA in a biological sample.


name: Grade 3 Edema of the Head and Neck, CTCAE


Neonatal hyperglycemia

description: Blood glucose concentration above the upper limit of established reference ranges in a newborn.


name: Atypical Melanocytic Nevus of Genital Type

description: A small, well circumscribed melanocytic neoplasm that arises from the vulva and affects women in their reproductive years. It is characterized by the presence of junctional nests of melanocytes. Some of the superficial melanocytes show atypia. During pregnancy the atypical melanocytic changes may appear more prominent. This neoplasm is not associated with the presence of dysplastic nevi in other anatomic areas.


Refractory Prostate Carcinoma

description: Prostate carcinoma that is resistant to treatment.


name: Recurrent Female Reproductive System Carcinoma

description: The reemergence of female reproductive system carcinoma after a period of remission.


Grade 2 Photosensitivity, CTCAE

description: Tender erythema covering 10-30% BSA


name: Lugano Classification Stage III Childhood Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


name: Therapy-Related Toxicity - Unacceptable to Patient

description: Indicates that a toxicity adverse effect has been experienced by a patient, and it is severe enough for the patient to discontinue the treatment.


name: Stage III Childhood Retinoblastoma by Toronto Guidelines v2

description: Regional extension: involvement of the orbit and/or preauricular or cervical lymph node extension. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Oral Cavity Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Grade 3 Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gastric Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the gastric wall.


Grade 2 Bronchial Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Eating disorder symptom

description: Abnormal eating behaviors, including binge eating, compulsive eating, emotional eating, night eating, and self-induced vomiting, though not at a level that rises to the diagnosis of eating disorder.


Transthyretin amyloid cardiomyopathy

description: Cardiomyopathy resulting from the deposition of misfolded transthyretin. The condition can be classified by the presence (hereditary transthyretin amyloid) or absence (wild-type transthyretin amyloid) of mutation(s) in the TTR gene, encoding transthyretin.


Grade 3 Delirium, CTCAE

description: Severe and acute confusional state; limiting self care ADL; urgent intervention indicated; new onset


name: Adenocarcinoma of the prostate metastatic

description: An adenocarcinoma that arises from the prostate gland and has spread to other anatomic sites.


Bladder Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the bladder.


Grade 5 Myelitis, CTCAE

description: Death


Stage IB Cervical Cancer AJCC v8

description: Stage IB includes: T1b, Any N, M0. T1b: Tumor with clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. It includes all macroscopically visible lesions, even those with superficial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 5 Hemolytic Uremic Syndrome, CTCAE

description: Death


name: Recurrent Intermediate Grade Adult Non-Hodgkin's Lymphoma


name: Grade 1 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Venous Stroke

description: Ischemic or hemorrhagic stroke resulting from cerebral venous thrombosis.


name: Fetus Small for Gestational Age with Oligohydraminos

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and shows evidence of oligohydramnios.


Cervical Cancer by FIGO Stage 2009

description: A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2009.


name: Non-Neoplastic Central Nervous System Disorder


name: Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Rectal Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 2 Edema of the Trunk and Genital Area, CTCAE


Grade 2 Viremia, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Grade 5 Pancreas Infection with Unknown Absolute Neutrophil Count, CTCAE


Vascular disorder of intestine

description: A non-neoplastic or neoplastic vascular disorder that affects the intestines.


Cerebellar sarcoma

description: An obsolete term referring to desmoplastic medulloblastoma.


name: Grade 4 Left Ventricular Diastolic Dysfunction, CTCAE


name: Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Gastric Non-Neoplastic Polyp

description: A non-neoplastic polyp that arises from the stomach.  This category includes hyperplastic polyps and hamartomatous polyps.


Grade 4 Hypohidrosis, CTCAE

description: Heat stroke


Grade 5 Vaginal Perforation, CTCAE

description: Death


name: Grade 2 Pulmonary Artery Intra-Operative Injury, CTCAE


Squamous Papilloma of the Urinary Tract

description: A rare papillary neoplastic growth that arises from the urothelial mucosa. It is characterized by the presence of fibrovascular cores lined by benign keratinizing squamous epithelium. There is no evidence of architectural or cytologic atypia. It usually occurs in elderly people and is found in the bladder and urethra.


Nail Loss, CTCAE

description: A disorder characterized by loss of all or a portion of the nail.


Stage IIIA Esophageal Cancer AJCC v7

description: Stage IIIA includes: For squamous cell carcinoma: (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Grade 4 Pulmonary Vein Intra-Operative Injury, CTCAE


Stage IB2 Cervical Cancer AJCC v8

description: Stage IB2 includes: T1b2, Any N, M0. T1b2: Tumor with clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Radiation anemia

description: Anemia arising due to radiation therapy.


name: Grade 1 Cranial Nerve VI Neuropathy, CTCAE


Seroma, CTCAE

description: A finding of tumor-like collection of serum in the tissues.


name: Grade 1 Intraoperative Arterial Injury, CTCAE

description: Primary repair of injured organ/structure indicated


name: Melanoma in Intermittently Sun-Exposed Skin

description: A melanoma that arises from the skin in the absence of severe actinic keratosis. It can arise from a pre-existing nevus or de novo.


Grade 3 Vaginal Inflammation, CTCAE

description: Severe discomfort or pain, edema, or redness; limiting self care ADL; small areas of mucosal ulceration


Invasive listeriosis

description: A bacterial infection by Listeria monocytogenes in a sterile body compartment.


name: Grade 5 Other Allergy and Immunology, CTCAE


Stage 0 Pancreatic Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. This includes high-grade pancreatic intraepithelial neoplasia (PanIn-3), intraductal papillary mucinous neoplasm with high-grade dysplasia, intraductal tubulopapillary neoplasm with high-grade dysplasia, and mucinous cystic neoplasm with high-grade dysplasia.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Defects in Intrinsic and Innate Immunity

description: A group of diseases or disorders caused by genetic defects within the immune system, comprised by: Mendelian susceptibility to mycobacterial disease (MSMD); Epidermodysplasia verruciformis (HPV); Predisposition to severe viral infection; Herpes simplex encephalitis (HSE); Predisposition to invasive fungal diseases; Predisposition to mucocutaneous candidiasis; TLR signaling pathway deficiencies with bacterial susceptibility; and other inborn errors of immunity related to nonhematopoietic tissues.


name: Lymphocyte-Depleted Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for lymphocyte-depleted classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Grade 1 Depression, CTCAE

description: Mild depressive symptoms


name: Grade 3 Pyramidal Tract Dysfunction, CTCAE


name: Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE


Metastatic Unresectable Sarcoma

description: A metastatic sarcoma that is not amenable to surgical resection.


name: Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Grade 4 Penile Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Lung Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Fever, CTCAE

description: A disorder characterized by elevation of the body's temperature above the upper limit of normal.


name: Grade 3 Acoustic Nerve Disorder NOS, CTCAE

description: Severe symptoms; limiting self care ADL


name: Locally Advanced Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that has spread to nearby tissues or lymph nodes.


name: Grade 5 Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Stage IIA Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIA includes: T2, N0, M0.  T2: Stomach/ duodenum /jejunum/ileum: tumor invades muscularis propria or is more than 1 cm in size; ampulla: tumor is more than 1 cm in size; colon or rectum: tumor invades muscularis propria or is more than 2 cm in size with invasion of lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Electrocardiogram T Wave Abnormal, CTCAE

description: A disorder characterized by Electrocardiogram T wave amplitude changes.


name: Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis

description: A myelodysplastic/myeloproliferative neoplasm characterized by marked thrombocytosis, anemia, erythroid lineage dysplasia, presence or absence of multilineage dysplasia, 15% or more ring sideroblasts, blasts less than 5% in bone marrow and less than 1% in peripheral blood, absence of BCR/ABL fusion, absence of SF3B1 mutation, absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions, and no history of other myelodysplastic/myeloproliferative neoplasms or myeloproliferative neoplasms and myelodysplastic syndromes.


Metastatic Appendix Adenocarcinoma

description: Appendix adenocarcinoma that has spread from its original site of growth to another anatomic site.


Grade 3 Vitreous Hemorrhage, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL; vitrectomy indicated


name: Grade 4 Cranial Nerve I Intra-Operative Injury, CTCAE


name: Hodgkin's disease nodular sclerosis stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 1 Hypoalbuminemia, CTCAE

description: <LLN-3 g/dL; <LLN-30 g/L


name: Grade 1 Lymphedema-Related Fibrosis, CTCAE


Grade 1 Gum Infection, CTCAE

description: Local therapy indicated (swish and swallow)


Grade 2 Hypernatremia, CTCAE

description: >150-155 mmol/L; intervention initiated


name: Ann Arbor Stage III AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Pancreatic Neuroendocrine Microtumor

description: A non-functioning pancreatic neuroendocrine tumor measuring less than 0.5 cm in diameter.


Refractory Neoplasm

description: A neoplasm that does not respond to treatment.


Posterior Subcapsular Cataract Grade 3

description: A stage of posterior subcapsular cataract characterized by 50% of the posterior capsule obscured by opacity. (Modified LOCS II)


Prostate cancer stage B

description: Tumor is clinically palpable but confined to the prostate.


Grade 2 Hypophysitis, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 1 Larynx Intra-Operative Injury, CTCAE


Jejunal Perforation, CTCAE

description: A disorder characterized by a rupture in the jejunal wall.


Metastatic Anal Canal Carcinoma

description: An anal canal carcinoma which has spread to another anatomic site.


Grade 3 Scalp Pain, CTCAE

description: Severe pain; limiting self care ADL


Grade 2 Nasal Congestion, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Malignant Peritoneal and Retroperitoneal Neoplasm

description: A primary or metastatic malignant neoplasm that affects the peritoneum and/or retroperitoneum.


Hypernatremia

description: Higher than normal levels of sodium in the circulating blood.


Stage IIA Cervical Cancer AJCC v6

description: Tumor without parametrial invasion.


Stage IVB Fallopian Tube Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1b. M1b: Fallopian tube cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine. (from AJCC 8th Ed.)


name: Stage IIIB Gestational Trophoblastic Tumor AJCC v7

description: Stage IIIB includes: Any T, M1a, Risk factors: high risk.  M1a: Lung metastasis.  (AJCC 7th ed.)


Recurrent Myxoid Glioneuronal Tumor

description: The reemergence of myxoid glioneuronal tumor after a period of remission.


name: Chronic total occlusion of coronary artery

description: Prolonged complete obstruction of the coronary artery. (ACC)


name: Grade 2 Muscular and Skeletal Hypoplasia, CTCAE


Anal Mucositis, CTCAE

description: A disorder characterized by ulceration or inflammation of the mucous membrane of the anus.


name: Artery NOS Intra-Operative Injury, CTCAE


name: Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


Fibrinolysis Shutdown

description: Acute impairment of breaking down fibrin clots leading to venous thromboembolism, stroke, and renal failure.


Metastatic Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to another anatomic site.


Grade 1 Hypermagnesemia, CTCAE

description: >ULN-3.0 mg/dL; >ULN-1.23 mmol/L


name: Grade 3 Pulmonary Vein Intra-Operative Injury, CTCAE


Hearing Impaired, CTCAE

description: A disorder characterized by partial or complete loss of the ability to detect or understand sounds resulting from damage to ear structures.


name: Grade 1 Small Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Lymphoma by AJCC v8 Stage

description: A term that refers to the staging of Hodgkin lymphoma and non-Hodgkin lymphoma according to the AJCC v8 classification guidelines.


name: Grade 3 Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Incarcerated inguinal hernia

description: The trapping of bowel or omentum inside the inguinal canal that cannot be reduced, resulting in inflammation, pain, nausea, and possible bowel obstruction.


Lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 3 Hyperhidrosis, CTCAE

description: Associated with electrolyte/hemodynamic imbalance


name: Grade 3 Adrenal Gland Intra-Operative Injury, CTCAE


Glycogen storage disease, type IX

description: Glycogen storage disease usually inherited in an X-linked recessive pattern.  It is characterized by a deficiency of hepatic phosphorylase kinase.


Grade 2 Tumor Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Pinhole meatus

description: A narrowing of the opening of the urethra at the external meatus.


name: Grade 4 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 3 Esophageal Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Hypothermia, CTCAE

description: Death


name: Grade 4 Liver Intra-Operative Injury, CTCAE


Radiating Chest Pain in Neck

description: The location of the radiating chest pain is in the neck.


Hemoglobin Level Finding

description: A finding that indicates the amount of hemoglobin in a sample.


name: Grade 2 Gastrointestinal Stoma Necrosis, CTCAE

description: Superficial necrosis; intervention not indicated


name: Grade 2 Trachea Intra-Operative Injury, CTCAE


name: Grade 1 Salivary Gland or Saliva Changes, CTCAE


name: Grade 5 Ear and Labyrinth Disorders - Other, Specify, CTCAE

description: Death


name: Grade 3 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


AIDS-Related Carcinoma

description: Carcinoma occurring in HIV-positive patients.


Paratesticular Carcinoma

description: A carcinoma that arises from the paratesticular structures.


Grade 4 Gallbladder Necrosis, CTCAE

description: Life-threatening consequences; urgent invasive intervention indicated


Monoclonal Hypergammaglobulinemia

description: A laboratory test result indicating abnormally high proliferation of the gamma globulins originating from one cell line.


Granuloma annulare aggravated

description: A chronic, inflammatory skin condition characterized by raised, ring shaped eruptions occurring singly or in groups; often on the tops of the hands, feet, elbows, and knees. It is commonly seen in children and young adults, and in women twice as much as men.


Bladder Cancer by AJCC v6 Stage

description: A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 6th edition.


Stage I Ampulla of Vater Cancer AJCC v7

description: Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0). T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Metastatic Malignant Neoplasm to the Cervix

description: A malignant neoplasm that has spread to the cervix from another anatomic site.


name: Grade 5 Endocrine Disorders - Other, Specify, CTCAE

description: Death


name: Grade 3 Other Renal or Genitourinary, CTCAE


Grade 2 Cheilitis, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Nephrotic Syndrome, CTCAE

description: A disorder characterized by symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.


Anal Canal Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process involving the anal canal.  When it is clinically noticeable, it may appear as an eczematous or papillary lesion, plaques, or papules.  Morphologically, it is characterized by loss of epithelial stratification and nuclear polarity, cytologic atypia, and the presence of mitotic figures.  It may be classified as low or high grade.


name: immune effector cell-associated neurotoxicity syndrome, grade 2

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 3, 4, 5, or 6 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken to voice commands.


Laryngeal nerve palsy

description: Damage to the laryngeal nerve that results in paralysis of the layrnx.


Grade 3 Sore Throat, CTCAE

description: Severe pain; limiting self care ADL; limiting ability to swallow


name: Grade 4 Thrombosis or Thrombus or Embolism, CTCAE


Acinar cell tumor

description: A benign or malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. It includes the acinar cell adenoma and acinar cell carcinoma.


name: Grade 1 Trachea Obstruction and Stenosis, CTCAE


Grade 4 Tumor Lysis Syndrome, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Budd-Chiari Syndrome, CTCAE

description: A disorder characterized by occlusion of the hepatic veins and typically presents with abdominal pain, ascites and hepatomegaly.


name: Helicobacter Pylori-Related Malignant Neoplasm


name: Grade 2 Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Acidosis, CTCAE

description: pH <normal, but >=7.3


description: A pleomorphic xanthoastrocytoma that arises from the supratentorial region of the brain.


Kidney Anastomotic Leak, CTCAE

description: A finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures).


Spinal nerves paralysis permanent

description: Spinal nerve paralysis that is irreversible.


Organic failure to thrive

description: Failure to thrive (FTT), that occurs in less than five percent of FTT cases; it is caused by acute or chronic disorders that interfere with nutritional uptake, including cleft palate, malabsorption due to cystic fibrosis, and short gut syndrome.


name: Low grade cervical glandular intraepithelial neoplasia

description: Cervical glandular intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Malignant Pancreatic Vipoma

description: A pancreatic neuroendocrine tumor producing vasoactive intestinal peptide (VIP).  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria.  It displays vascular invasion and metastasizes to other anatomic sites.  One third of cases are metastatic at the time of diagnosis.


Grade 4 Bullous Dermatitis, CTCAE

description: Blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated


name: Grade 1 Cranial Nerve VIII Intra-Operative Injury, CTCAE


name: Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 4 Other Dermatology or Skin, CTCAE


name: Grade 2 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


Grade 5 Fever, CTCAE

description: Death


Locally Recurrent Gastric Carcinoma

description: The reemergence of gastric carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Gallbladder Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the gallbladder region.


name: Grade 1 Serum Glutamic Pyruvic Transaminase, CTCAE


name: Recurrent Primary Central Nervous System Neoplasm

description: The reemergence of a primary central nervous system neoplasm after a period of remission.


Grade 1 Hair Color Changes, CTCAE

description: Present


Angiosarcoma Associated with Lymphedema

description: An angiosarcoma that develops in association with long standing lymphedema.


T/NK-Cell Lymphoproliferative Disorder

description: A non-neoplastic or neoplastic proliferation of T-lymphocytes and/or NK-cells.


name: Central Nervous System Langerhans Cell Histiocytosis

description: Rare involvement of the central nervous system by Langerhans cell histiocytosis.


name: Injury to peritoneum without mention of open wound into cavity

description: Trauma to the peritoneum without indication of associated damage to the skin and other internal and external tissues.


Rectal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures).


name: Grade 3 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Anorectal Infection, CTCAE

description: A disorder characterized by an infectious process involving the anal area and the rectum.


Acute Heart Failure Related to COVID-19

description: New or worsening signs of heart failure in a patient with probable or confirmed acute COVID-19. This can be the first presentation or it can reflect an acute decompensation in a patient with history of chronic heart failure.


name: Grade 5 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Mucinous cystic neoplasm with low-grade intraepithelial neoplasia of gallbladder

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of mild atypia.


name: Grade 4 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Rectal Pain, CTCAE

description: Mild pain


Stage IIIA Testicular Cancer AJCC v8

description: Stage IIIA includes: (Any pT/TX, Any N, M1a, S0); (Any pT/TX, Any N, M1a, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Grade 4 Esophageal Perforation, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 3 Tracheostomy Site Bleeding, CTCAE

description: Transfusion indicated; invasive intervention indicated


name: Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Sacral Fistula

description: A pathologic communication between the skin and the dural space that is located 5-25 mm from the anal verge.


name: Grade 4 Upper Gastrointestinal Hemorrhage NOS, CTCAE


name: Grade 3 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


name: Extrahepatic Bile Duct Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: Locally Advanced Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Wheezing, CTCAE

description: Death


Retinoblastoma, differentiated

description: A retinoblastoma with well differentiated features. It often produces Flexner-Wintersteiner rosettes or Homer-Wright rosettes. In some cases the tumor cells form fleurettes.


Metastatic Gastric Carcinoma

description: A gastric carcinoma that has spread from its original site of growth to another anatomic site.


Grade 5 Pharyngeal Necrosis, CTCAE

description: Death


name: Mucositis and Stomatitis by Clinical Examination Classification, CTCAE


Mesothelioma malignant localised

description: A malignant mesothelioma with the gross appearance of a circumscribed serosal lesion and the microscopic appearance of diffuse malignant mesothelioma, without evidence of diffuse spread.


name: Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

description: The reemergence of a blastic plasmacytoid dendritic cell neoplasm after a period of remission.


name: Grade 2 Liver Intra-Operative Injury, CTCAE


name: Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Abdominal Distension, CTCAE

description: Symptomatic; limiting instrumental ADL


name: Grade 5 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Meningococcal endocarditis

description: Endocarditis caused by bacterial infection with Meningococcus species.


Childhood Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that occurs during childhood.


name: Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 4 Neuralgia and Peripheral Nerve Pain, CTCAE


name: Grade 4 Adult Respiratory Distress Syndrome, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Cervical Germ Cell Tumor

description: A rare germ cell tumor that arises from the cervix. Examples include mature cystic teratoma, yolk sac tumor, and choriocarcinoma.


Grade 1 Cushingoid, CTCAE

description: Mild symptoms; intervention not indicated


Hereditary factor I deficiency disease

description: An inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


Accessory Nerve Disorder, CTCAE

description: A disorder characterized by dysfunction of the accessory nerve (eleventh cranial nerve).


name: Grade 2 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


name: Grade 2 Muscle Weakness Right-Sided, CTCAE

description: Symptomatic; evident on physical exam; limiting instrumental ADL


Childhood Malignant Endocrine Neoplasm

description: A malignant neoplasm arising from the epithelial cells of an endocrine organ during childhood.


Stage IIC Appendix Carcinoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 5 Dyspnea, CTCAE

description: Death


Grade 2 Rectal Fissure, CTCAE

description: Symptomatic


Acoustic shock

description: Neurophysiological and psychological symptoms caused by sudden and unexpected loud noise.


Grade 3 Cervicitis Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Stage 0 Pancreatic Cancer AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Cutaneous Histiocytic and Dendritic Cell Neoplasm

description: A histiocytic and dendritic cell neoplasm that affects the skin.


Bloating, CTCAE

description: A disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen.


name: Childhood Astrocytoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood astrocytoma according to the Toronto childhood cancer staging guidelines v2. This staging system is the same for both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Vaginal Dryness, CTCAE

description: Severe vaginal dryness resulting in dyspareunia or severe discomfort


name: Grade 2 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Anal Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the anal region.


Metastatic Malignant Skin Neoplasm

description: A malignant neoplasm of the skin that has spread to other anatomic sites.


Grade 3 Extrapyramidal Disorder, CTCAE

description: Severe involuntary movements or torticollis; limiting self care ADL


name: Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7

description: A rare acute myeloid leukemia that occurs in childhood and is characterized by deletion of chromosome 7.


name: Grade 4 Paranasal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Superior Vena Cava Vein Injury, CTCAE


name: Grade 4 Eye Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Intraoperative Breast Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Muscular and Skeletal Hypoplasia, CTCAE


Stage IB1 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma with equal or more than 5 mm depth of stromal invasion, and less than 2 cm in greatest dimension. (FIGO 2018)


External Ear Pain

description: Painful sensation in the external ear region.


Fibrinogen Deficiency

description: A usually inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


name: Grade 5 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Ampulla of Vater Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Disseminated adenocarcinoma

description: Adenocarcinoma that is spread throughout the body.


name: Recurrent Endometrial Squamous Cell Carcinoma

description: The reemergence of endometrial squamous cell carcinoma after a period of remission.


Unresectable Carcinoma

description: Carcinoma that is not amenable to surgical resection.


name: Refractory Metastatic Pancreatic Adenocarcinoma

description: Metastatic pancreatic adenocarcinoma that is resistant to treatment.


name: Intraoperative Respiratory Injury, CTCAE

description: A finding of damage to the respiratory system during a surgical procedure.


name: Grade 3 Other Sexual Reproductive Function, CTCAE


Grade 3 Fecal Incontinence, CTCAE

description: Severe symptoms; elective operative intervention indicated


name: POLE-Ultramutated Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene that result in an ultra-mutated tumor phenotype.


Grade 2 Gum Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Grade 3 Major Visceral Vein Intra-Operative Injury, CTCAE


name: Hodgkin's disease nodular sclerosis stage I supradiaphragmatic


name: Grade 5 Disseminated Intravascular Coagulation, CTCAE

description: Death


Oligodendroblastoma

description: An obsolete term referring to neoplasms arising from oligodendrocytes.


name: Grade 2 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Periorbital Edema, CTCAE

description: Soft or non-pitting


name: Recurrent Abdominal Neuroendocrine Neoplasm

description: The reemergence of an abdominal neuroendocrine neoplasm after a period of remission.


name: Grade 3 Peripheral Nerve Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Advanced Sarcoma

description: A sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Adenovirus Infection

description: An adenovirus infection that has recurred after a period of remission.


Dysarthria, CTCAE

description: A disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech.


name: Grade 5 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Eye NOS Intra-Operative Injury, CTCAE


Grade 2 Cystitis Noninfective, CTCAE

description: Moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL


Grade 4 Hypotension, CTCAE

description: Life-threatening consequences and urgent intervention indicated


Grade 3 Multi-Organ Failure, CTCAE

description: Shock with azotemia and acid-base disturbances; significant coagulation abnormalities


Grade 4 Febrile Neutropenia, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Anal Sphincter Intra-Operative Injury, CTCAE


Vitreoretinal Disorder

description: A disorder affecting the vitreous fluid and retina.


Grade 2 Atrial Flutter, CTCAE

description: Non-urgent medical intervention indicated


Grade 2 Flu Like Symptoms, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Uterine Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the uterine corpus or the cervix. Representative examples include endometritis, uterine adenomyosis, and cervicitis.


name: Acute Myeloid Leukemia with ASXL1 Mutation

description: An acute myeloid leukemia associated with ASXL1 gene mutation.


Grade 4 Bladder Perforation, CTCAE

description: Life-threatening consequences; organ failure; urgent operative intervention indicated


Grade 3 Intestinal Stoma Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Grade 5 Heart Failure, CTCAE

description: Death


Stage IV Esophageal Cancer AJCC v6

description: Stage IV includes: Any T, Any N, M1. IVA: Any T, Any N, M1a. IVB: Any T, Any N, M1b.  M1: Distant Metastasis. (AJCC 6th ed.) -2003


name: Grade 3 Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


name: tubular adenoma of extrahepatic bile duct

description: An adenoma that arises from the extrahepatic bile ducts.  It is characterized by the presence of a tubular pattern.


name: Grade 3 Outer Ear NOS Intra-Operative Injury, CTCAE


Grade 3 Neonatal Diarrhea, AE

description: An adverse event in a newborn characterized by an increase of 7 stools or more per day over baseline; severe increase in ostomy output compared to baseline; signs of dehydration.


EBV-Related Malignant Neoplasm

description: A malignant neoplasm that develops in a patient infected with Epstein-Barr virus (EBV) and in which there is a well-documented association between the malignancy and EBV. Representative examples include EBV-related lymphomas and carcinomas.


name: Grade 2 Oculomotor Nerve Disorder, CTCAE


name: Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


Uterine Ligament Papillary Cystadenoma

description: A cystadenoma that arises from the broad or other uterine ligaments. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


name: Grade 3 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Lung Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Uterine Corpus Cancer

description: Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1). T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Sore Throat, CTCAE

description: A disorder characterized by marked discomfort in the throat


name: Irritability in Children Less Than 3 Years of Age, CTCAE


Grade 5 Esophageal Necrosis, CTCAE

description: Death


neoplasm of optic tract

description: A benign or malignant neoplasm that affects the optic tract.


name: Portal Vein Intra-Operative Injury, CTCAE


Grade 3 Middle Ear Inflammation, CTCAE

description: Mastoiditis; necrosis of canal soft tissue or bone


Sarcomatoid carcinoma of the prostate

description: A rare acinar adenocarcinoma of the prostate gland with unfavorable prognosis. It is composed of both malignant glandular and sarcomatous components. The sarcomatous component contains a malignant spindle cell proliferation or specific mesenchymal elements including osteosarcoma, chondrosarcoma, and leiomyosarcoma.


name: Grade 2 Cranial Nerve XII Neuropathy, CTCAE


name: Malignant melanoma in giant pigmented nevus

description: A melanoma arising in a giant congenital melanocytic nevus. The risk of developing a melanoma in a giant congenital melanocytic nevus has been reported to be between 5% and 50%. The incidence of developing melanoma is higher before the age of 10 and in adult life.


Grade 3 Gastric Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated; limiting self care ADL


Grade 4 Mucosal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Inner Restlessness

description: A feeling of unrest and/or an inability to feel calm or relaxed.


Early Disseminated Lyme Disease

description: An early stage of Lyme disease that may present days to weeks after a tick bite with relapsing signs of a red, concentrically-expanding rash (erythema migrans), facial palsy, meningismus, neuralgia, heart palpitations, and dizziness.


name: Grade 3 Neck Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pancreatic Delta Cell Adenoma

description: An endocrine neoplasm arising from the delta cells of the pancreas which produce somatostatin. It does not show evidence of vascular invasion or metastasis to other anatomic sites.


Transfusion hemosiderosis

description: Accumulation of iron in internal organs that results from repeated blood transfusions.


name: Grade 4 Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


Cervical Adenocarcinoma In Situ

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Microinvasive Malignant Neoplasm

description: A malignant neoplasm that has minimal stromal invasion.


Palsy of accessory nerve

description: Partial or complete paralysis of the spinal accessory nerve.


name: Advanced Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Lipase Increased, CTCAE

description: >2.0-5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic


name: Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma invading into the bladder muscularis propria.


name: Grade 3 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Major Visceral Artery Intra-Operative Injury, CTCAE


Grade 4 Feeding Intolerance, AE

description: A feeding intolerance adverse event in a newborn characterized by life-threatening consequences.


name: Grade 3 Left Ventricular Diastolic Dysfunction, CTCAE


Chronic Kidney Disease, CTCAE

description: A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.


name: Grade 1 Phantom Pain Associated with Missing Limb, CTCAE


Non-Neoplastic Retroperitoneal Disorder

description: A non-neoplastic disorder that affects the retroperitoneum.


Grade 1 Urinary Urgency, CTCAE

description: Present


Grade 1 Postoperative Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Adenocarcinoma, metastatic

description: An adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Grade 2 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Uterine Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Grade 3 Dry Skin, CTCAE

description: Covering >30% BSA and associated with pruritus; limiting self care ADL


Grade 2 Hypertension, CTCAE

description: Adult: Systolic BP 140-159 mm Hg or diastolic BP 90-99 mm Hg if previously WNL; change in baseline medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg; monotherapy indicated initiated; Pediatric and adolescent: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated; systolic and /or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile; Adolescent: Systolic between 130-139 or diastolic between 80-89 even if < 95th percentile


Grade 3 Atrial Flutter, CTCAE

description: Symptomatic, urgent intervention indicated; device (e.g., pacemaker); ablation


name: Grade 2 Peripheral Motor Neuropathy, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 5 Hypotension, CTCAE

description: Death


Grade 5 Gastric Hemorrhage, CTCAE

description: Death


Childhood Genitourinary System Neoplasm

description: A neoplasm that affects the genitourinary system during childhood.


Bronchopleural Fistula, CTCAE

description: A disorder characterized by an abnormal communication between a bronchus and the pleural cavity.


name: Grade 5 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Blood Bilirubin Increased, CTCAE

description: A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.


Metastatic Glioblastoma

description: Glioblastoma that has spread from its original site of growth to another anatomic site.


Cystic fibrosis pulmonary exacerbation

description: An acute episode of worsening pulmonary symptoms related to cystic fibrosis.


Grade 4 Laryngeal Mucositis, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


name: Immunodeficiency-Related Central Nervous System Lymphoma

description: A lymphoma that arises from the central nervous system in patients with acquired immunodeficiency conditions or rarely, hereditary immunodeficiency syndromes.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 2, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 2 Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol.


Grade 5 Duodenal Stenosis, CTCAE

description: Death


name: Conjunctiva Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage IIA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 2 Major Visceral Vein Intra-Operative Injury, CTCAE


name: Ampulla of Vater Gangliocytic Paraganglioma

description: An extra-adrenal paraganglioma that arises from the ampulla of Vater and the periampullary region.  It consists of a mixture of neuroendocrine cells, Schwann-like cells, and ganglion cells.


name: Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2

description: A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with CBFA2T3-GLIS2 chimeric oncogene and has an unfavorable prognosis.


Desmoplastic trichilemmoma

description: A variant of tricholemmoma that is characterized by extensive sclerotic stroma formation.


Localized Malignant Neoplasm

description: A malignant neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


name: Grade 3 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Non-Neoplastic Genitourinary System Disorder

description: A non-neoplastic disorder that affects the genitourinary system.


Grade 2 Neonatal Bradyarrhythmia, AE

description: A bradyarrhythmia adverse event in a newborn characterized by no change in age-appropriate behavior; requiring minor care changes (e.g. increased monitoring).


name: Stage IIA Esophageal Adenocarcinoma AJCC v7

description: Stage IIA includes: T2, N0, M0, G3.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. G3: Poorly differentiated.  (AJCC 7th ed.)


name: Grade 4 Genitourinary Stoma Prolapse, CTCAE


Grade 3 Periorbital Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 4 Bile Duct Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Chemically Induced Urinary Tract Toxicity


Hyponatremia with Hypoosmolality

description: Abnormally low serum sodium levels in the setting of electrolyte/fluid imbalance. This condition may be the result of excessive intake or retention of water and/or excretion of salt.


Iodine deficiency

description: A deficiency of iodine in the diet.


Airsickness

description: A sensation of discomfort associated with air travel that may include nausea, vomiting, dizziness, or sweating.


Stage II Appendix Carcinoma AJCC v8

description: Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4a: Tumor invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Wheezing, CTCAE

description: Moderate symptoms; medical intervention indicated; limiting instrumental ADL


name: Pneumonitis and Pulmonary Infiltrates, CTCAE


Grade 5 Seizure, CTCAE

description: Death


name: Grade 2 Ureter Intra-Operative Injury, CTCAE


Dyspareunia, CTCAE

description: A disorder characterized by painful or difficult coitus.


name: Grade 5 Lower Gastrointestinal Hemorrhage, CTCAE

description: Death


name: Grade 3 Cranial Nerve VIII Neuropathy, CTCAE


name: Grade 2 Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Grade 3 Hypermagnesemia, CTCAE

description: >3.0-8.0 mg/dL; >1.23-3.30 mmol/L


name: Grade 2 Cervix Intra-Operative Injury, CTCAE


name: Grade 2 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Gastrointestinal Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Grade 1 Edema of the Trunk and Genital Area, CTCAE


name: Grade 3 Cranial Nerve XII Intra-Operative Injury, CTCAE


name: Grade 5 Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Adenosis

description: Any disease or disorder of a gland, characterized by abnormal development or enlargement of the gland.


name: Metastatic Primary Malignant Central Nervous System Neoplasm

description: A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to other sites.


name: Grade 5 Cranial Nerve III Neuropathy, CTCAE


name: Grade 3 Left Ventricular Systolic Dysfunction, CTCAE

description: Symptomatic due to drop in ejection fraction responsive to intervention


Grade 2 Pleural Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 4 Neonatal Sinus Bradycardia, AE

description: A sinus bradycardia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.


name: Adverse Event Associated with Coagulation


Mild esophageal dysplasia

description: A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal epithelium.  (WHO, 2000)


name: Prostate Acinar Microcystic Adenocarcinoma

description: Acinar prostate adenocarcinoma characterized by the presence of microcystic foci in radical prostatectomy specimens.


Radiation-Recall Dermatitis

description: Acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmacologic agent.


Grade 3 Pancreatic Necrosis, CTCAE

description: Tube feeding or TPN indicated; invasive intervention indicated


name: Grade 5 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Anal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: AIDS-Related Pelvic Inflammatory Disease

description: Pelvic inflammatory disease that develops in a patient with HIV/AIDS.


Stage I Merkel Cell Carcinoma AJCC v7

description: Stage I includes: IA: (T1, pN0, M0) and IB: (T1, cN0, M0).  T1: Primary tumor equal or less than 2 cm in size.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Grade 3 Prostatic Pain, CTCAE

description: Severe pain; limiting self care ADL


Hidroacanthoma simplex

description: A rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct.


Grade 2 Breast Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 2 Bladder Perforation, CTCAE

description: Invasive intervention not indicated


name: Lugano Classification Limited Stage Childhood Hodgkin Lymphoma AJCC v8

description: Limited stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


HPV-related carcinoma

description: A carcinoma associated with the presence of human papillomavirus infection.


Grade 4 Sinusitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Intraoperative Breast Injury, CTCAE

description: Death


name: Grade 2 Allergic Rhinitis Including Sneezing Nasal Stuffiness Postnasal Drip, CTCAE


name: Grade 2 Small Bowel Stricture or Stenosis NOS, CTCAE


Grade 2 Growth Hormone Abnormal, CTCAE

description: Symptomatic; medical intervention indicated; limiting instrumental ADL


Duodenal Infection, CTCAE

description: A disorder characterized by an infectious process involving the duodenum.


name: Hodgkin's disease lymphocyte depletion type stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Grade 5 Neonatal Gastrointestinal Bleeding, AE

description: A gastrointestinal bleeding adverse event in a newborn which results in death.


name: Grade 2 Small Intestinal Obstruction, CTCAE

description: Symptomatic; altered GI function; limiting instrumental ADL


name: Stage I Gestational Trophoblastic Tumor AJCC v7

description: Stage I includes: (T1, M0, Risk factors: unknown); IA (T1, M0, Risk factors: low risk); IB (T1, M0, Risk factors: high risk).  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIIA Cervical Cancer FIGO 2009

description: Cervical carcinoma involving lower one-third of the vagina. (FIGO 2009)


Grade 3 Rash Acneiform, CTCAE

description: Papules and/or pustules covering >30% BSA with moderate or severe symptoms; limiting self-care ADL; associated with local superinfection with oral antibiotics indicated


Stage III Ureter Cancer AJCC v7

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Peritoneal laceration

description: A cut or tear of the peritoneum.


Digestive System Hemangioma

description: A hemangioma arising from any part of the digestive system.


FancD2 Nuclear Foci Present

description: A laboratory test result indicating the presence of Fanconi anemia group D2 protein nuclear foci in cells, in response to DNA damage.


Xeroderma

description: A non-neoplastic disorder characterized by abnormally dry skin.  Causes include vitamin A deficiency, sunlight exposure, medications, metabolic disorders, autoimmune disorders, and hereditary genetic disorders.


name: Malignant Esophageal Neoplasm by Topographic Region

description: Esophageal segments used primarily in pathology, and distinct from the anatomic segments used for clinical purposes.


name: Colorectal Cancer by Astler-Coller Stage


name: Grade 4 Gastrointestinal Disorders - Other, Specify, CTCAE


Jejunal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site.


name: Grade 2 Cranial Nerve XI Neuropathy, CTCAE


name: Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage II includes: T3, N0, M0. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Acidophil carcinoma

description: A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes.


name: Childhood Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Lymphocyte-depleted classic Hodgkin lymphoma occurring in childhood.


Grade 3 Dry Mouth, CTCAE

description: Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min


Grade 3 Vomiting, CTCAE

description: Tube feeding, TPN, or hospitalization indicated


Grade 5 Esophageal Infection, CTCAE

description: Death


name: Grade 2 Supraventricular Tachycardia, CTCAE

description: Non-urgent medical intervention indicated


Grade 2 Thromboembolic Event, CTCAE

description: Medical intervention indicated


Transplant-Related Malignant Neoplasm

description: A malignant neoplasm that arises in a patient with a history of organ transplantation.


Grade 3 Splenic Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 1 Pulmonary Artery Intra-Operative Injury, CTCAE


name: Clinical Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Small Intestinal Perforation, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 3 Neonatal Spontaneous Intestinal Perforation, AE

description: An adverse event in a newborn characterized by presence of spontaneous intestinal perforation (SIP), non-urgent medical stabilization and surgical intervention indicated.


Acoustic Nerve Disorder NOS, CTCAE

description: A disorder characterized by dysfunction of the acoustic nerve (eighth cranial nerve).


name: Grade 2 Oral Cavity NOS Intra-Operative Injury, CTCAE


name: Metastatic Malignant Neoplasm in the Reproductive System

description: The spread of a malignant neoplasm to the male or female reproductive system from an adjacent or distant anatomic site.


Febrile Neutropenia, CTCAE

description: A disorder characterized by an ANC <1000/mm3 and a single temperature of >38.3 degrees C (101 degrees F) or a sustained temperature of >=38 degrees C (100.4 degrees F) for more than one hour


Childhood Hodgkin Lymphoma

description: Hodgkin lymphoma occurring in childhood.


Intracystic Papillary Breast Carcinoma

description: An intraductal breast carcinoma characterized by a papillary growth within a large cystic duct. There is no evidence of invasion of the breast parenchyma.


Metastatic Esophageal Carcinoma

description: A carcinoma that arises from the esophagus and has metastasized to another anatomic site.


Grade 5 Bronchial Fistula, CTCAE

description: Death


Grade 2 Uterine Perforation, CTCAE

description: Invasive intervention not indicated


Antepartum Obstetric Septic Embolism

description: Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the antepartum period.


name: Grade 2 Vaccination Site Lymphadenopathy, CTCAE

description: Localized ulceration; generalized lymph node enlargement


name: Urinary Tract Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Hair Texture Abnormal, CTCAE

description: A disorder characterized by a change in the way the hair feels.


name: Grade 4 Superior Vena Cava Intra-Operative Injury, CTCAE


Oral Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the mouth.


name: Unresectable Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that is not amenable to surgical resection.


Esophageal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the esophagus.


name: Parotid Gland Intra-Operative Injury, CTCAE


name: Grade 4 Personality and Behavioral Change, CTCAE


name: Scrotum Infection with Unknown Absolute Neutrophil Count, CTCAE


Extrahepatic Bile Duct Lymphoma

description: A lymphoma that arises from the extrahepatic bile ducts, with the bulk of the disease located at this site.


Stage I Testicular Cancer AJCC v8

description: Stage I includes: pT1-T4, N0, M0, SX. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. pT2: Testicular cancer which is limited to testis (including rete testis invasion) with lymphovascular invasion or invades hilar soft tissue or epididymis or penetrates visceral mesothelial layer covering the external surface of tunica albuginea with or without lymphovascular invasion. pT3: Testicular cancer in which the tumor invades spermatic cord with or without lymphovascular invasion. pT4: Testicular cancer in which the tumor invades scrotum with or without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Grade 3 Pneumothorax, CTCAE

description: Sclerosis and/or operative intervention indicated; hospitalization indicated


Keratin-Filled Cyst

description: A cyst that contains keratin.


name: Myopathy Secondary to Fatty Acid Oxidation Disorder

description: A myopathy that was caused by a primary disorder of fatty acid oxidation.


name: Grade 4 Fallopian Tube Stricture or Stenosis, CTCAE


name: NF1-Associated Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is associated with NF1 gene inactivation and a history of neurofibromatosis type 1.


Grade 1 Fat Atrophy, CTCAE

description: Covering <10% BSA and asymptomatic


Grade 4 Gallbladder Perforation, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Dentophobia

description: A persistent, irrational fear of treatment, whether preventative or therapeutic, by a dentist, coupled with compulsive desire to avoid any such situation.


name: Grade 4 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IIIC Vulvar Cancer AJCC v7

description: Stage IIIC includes: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


Perinatal disorder

description: A non-neoplastic or neoplastic disorder occurring during the period from about five months before birth to one month after birth.


Grade 5 Gastric Anastomotic Leak, CTCAE

description: Death


Grade 1 Teratoma

description: A teratoma that contains mature tissue elements and a limited amount of immature tissue elements.


Grade 1 Atrial Flutter, CTCAE

description: Asymptomatic, intervention not indicated


name: Grade 5 Paroxysmal Atrial Tachycardia, CTCAE

description: Death


name: Grade 1 Alanine Aminotransferase Increased, CTCAE

description: >ULN-3.0 x ULN if baseline was normal; 1.5-3.0 x baseline if baseline was abnormal


Vaginal Neuroendocrine Carcinoma

description: A rare neuroendocrine carcinoma that arises from the vagina. This category includes small cell and large cell neuroendocrine carcinoma.


name: Pathologic Stage IV Cutaneous Melanoma AJCC v8

description: Stage IV includes: Any T, Tis, Any N, M1. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. M1: Evidence of distant metastasis. (AJCC 8th ed.)


Grade 1 Skin Atrophy, CTCAE

description: Covering <10% BSA; associated with telangiectasias or changes in skin color


Grade 4 Pulmonary Edema, CTCAE

description: Life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated


Hypothermia, CTCAE

description: A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below.


name: Hernia with Obstruction without Mention of Gangrene

description: The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, which results in obstruction, without mention of necrosis of the herniated contents.


name: Stage IIB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Dysmenorrhea, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 2 Body Odor, CTCAE

description: Pronounced odor; psychosocial impact; patient seeks medical intervention


Atypical adenomatous hyperplasia

description: Proliferation of glandular epithelial cells associated with the presence of cytologic atypia and architectural growth pattern changes.


Rare Non-Neoplastic Disorder

description: A non-neoplastic disorder that is uncommon.


Stage IVC Appendix Carcinoma AJCC v8

description: Stage IVC includes: Any T, Any N, M1c, Any G. M1c: Metastasis to sites other than peritoneum. (AJCC 8th ed.)


Grade 1 Menorrhagia, CTCAE

description: Mild; iron supplements indicated


Grade 2 Bronchial Stricture, CTCAE

description: Symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators)


name: Recurrent Digestive System Neuroendocrine Neoplasm

description: The reemergence of a digestive system neuroendocrine neoplasm after a period of remission.


Cecal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the cecum.


description: Rosai-Dorfman-Destombes disease affecting the skin. It manifests with multiple papules, nodules, or plaques.


name: Grade 3 Cranial Nerve IV Neuropathy, CTCAE


name: Hypoxic ischemic encephalopathy neonatal

description: Injury to the central nervous system in the newborn period that occurs when there is insufficient delivery of oxygen to all or part of the brain.


Infection-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific infectious agent.


Vaso-Occlusive Crisis

description: An exacerbation of sickle cell disease.


name: Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Urinary Frequency, CTCAE

description: Present


name: Grade 2 Reproductive System and Breast Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Refractory T-Cell Prolymphocytic Leukemia

description: T-cell prolymphocytic leukemia that is resistant to treatment.


Skin Lesion Less Than 15 mm

description: A skin lesion that measures less than 15 mm in greatest dimension.


Grade 5 Vulval Infection, CTCAE

description: Death


name: Grade 1 Reproductive System and Breast Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Locally Advanced Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Mature T-Cell and NK-Cell Neoplasm

description: The reemergence of mature T-cell and NK-cell neoplasm after a period of remission.


Status Migrainosus

description: An episode of migraine that persists for more than 72 hours.


Malabsorption, CTCAE

description: A disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea.


Grade 2 Methemoglobinemia, CTCAE

description: >ULN


Malignant neoplasm aggravated

description: A malignant neoplasm that shows clinical and/or pathologic progression.


Atrophy of the Uterine Cervix

description: A condition characterized by the absence of squamous maturation in the cervical epithelium. It is associated with decreased estrogen production.


Eccrine Poroma

description: A poroma with eccrine differentiation.


name: Endometrial Endometrioid Adenocarcinoma with Papillae


Stage IA1 Cervical Cancer AJCC v8

description: Stage IA1 includes: T1a1, Any N, M0. T1a1: Invasive cervical carcinoma with measured stromal invasion of 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. M0: No distant metastasis. (AJCC 8th Ed.)


Severe Chronic Active EBV Infection

description: A severe form of chronic Epstein-Barr virus infection characterized by continued intermittent fever, lymphadenopathy, thrombocytopenia, lymphocytopenia, neutropenia, polyclonal gammopathy, and greatly elevated titers for antibodies to EBV-related antigens.


name: Metastatic Malignant Genitourinary System Neoplasm

description: A malignant neoplasm that arises from the genitourinary system and has metastasized to other anatomic sites.


name: Grade 5 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Renal pelvis fistula

description: An abnormal communication between the renal pelvis and another anatomic site.


Grade 3 Wheezing, CTCAE

description: Severe respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated


Metastatic Gallbladder Carcinoma

description: A gallbladder carcinoma that has spread from the original site of growth to other anatomic sites.


Intraoperative Renal Injury, CTCAE

description: A finding of damage to the kidney during a surgical procedure.


name: Grade 3 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Juvenile Myoclonic Epilepsy, Intractable, without Status Epilepticus

description: Intractable juvenile myoclonic epilepsy which is not associated with an acute, prolonged epileptic crisis.


Adenocarcinoma gastric recurrent

description: The reemergence of gastric adenocarcinoma after a period of remission.


name: Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Peritoneal Dialysis Catheter-Associated Peritonitis

description: Infection of the peritoneum related to a peritoneal dialysis catheter.


name: Acute on chronic combined systolic and diastolic heart failure

description: Acute decompensation of chronic combined systolic and diastolic congestive heart failure.


Disseminated Listeriosis

description: A bacterial infection by Listeria monocytogenes in two or more non-contiguous sterile body compartments.


name: Superficial Epithelioma with Sebaceous Differentiation

description: A benign epithelial neoplasm occurring in the head, neck or back region. It is characterized by proliferation of basaloid cells in the upper dermis with broad attachments to the epidermis.


name: Grade 2 Female Genital Tract Fistula, CTCAE


name: Grade 3 Throat and Pharynx and Larynx Pain, CTCAE


name: Fallopian Tube Stricture or Stenosis, CTCAE


Refractory Anaplastic Ganglioglioma

description: Anaplastic ganglioglioma that is resistant to treatment.