name: Grade 2 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Stage IIB Esophageal Adenocarcinoma AJCC v7

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Stage IIB includes: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

description: The reemergence of acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A after a period of remission.


Grade 3 Malabsorption, CTCAE

description: Inability to aliment adequately; TPN indicated


Recurrent Lymphoproliferative Disorder

description: The reemergence of a lymphoproliferative disorder after a period of remission.


name: Grade 5 Pharynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Recurrent Digestive System Carcinoma

description: The reemergence of carcinoma in any part of the digestive system after a period of remission.


Blennorrhagic arthritis

description: A form of reactive arthritis that is associated with lesions on both the palms of the hands and the soles of the feet.


name: Metastatic Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Invasive Bladder Urothelial Carcinoma with Glandular Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits glandular differentiation.


Grade 2 Optic Nerve Disorder, CTCAE

description: Moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


Myelophthisis

description: A condition resulting from the destruction of bone marrow precursor cells and their stroma. Bone marrow is displaced by fibrosis, tumors, or granulomas.


Jejunal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the jejunal wall.


Congenital Unilateral Cataract

description: Cataract in one eye that is present at birth.


Grade 4 Blurred Vision, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


name: Grade 4 Otitis External Ear Non Infectious, CTCAE


Keratitis caused by infection

description: Inflammation of the cornea secondary to an infectious process.


Craniopharyngioma malignant

description: A rare condition characterized by the development of a carcinoma in a pre-existing craniopharyngioma.


Grade 2 Neonatal Edema, AE

description: An adverse event in a newborn characterized by moderate edema; no change in age appropriate behavior; requiring minor care changes (e.g. alteration in fluid management).


Stage III Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 2 External Ear Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Localized Carcinoma

description: A carcinoma that is confined to a specific site without evidence of spread to other anatomic sites.


Childhood Malignant Glioma

description: A malignant glioma that occurs during childhood.


name: Stage I Adult Diffuse Large Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


name: Grade 3 Female Genital Tract Fistula, CTCAE


name: Gastric Pylorus Carcinoma In Situ AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Hodgkin's disease, nodular sclerosis - mixed cellularity

description: Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules contain scattered Reed-Sternberg cells. The background cellular infiltrate is lymphocytic, mixed, or fibrohistiocytic.


Grade 2 Testicular Disorder, CTCAE

description: Symptomatic but not interfering with sexual function; intervention not indicated; limiting instrumental ADL


name: Recurrent T-Cell Prolymphocytic Leukemia

description: The reemergence of T-cell prolymphocytic leukemia after a period of remission.


Cheilognathouranoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip, hard and/or soft palate and upper jaw.


name: Lymphocyte Predominant Type Hodgkin's Disease

description: An antiquated term that refers either to nodular lymphocyte predominant Hodgkin lymphoma or to lymphocyte-rich classical Hodgkin lymphoma.


Fetomaternal Transfusion

description: Loss of fetal blood into the maternal circulation.


Cerebellar Peduncle Neoplasm

description: A benign or malignant neoplasm that affects the cerebellar peduncle.


name: Grade 5 Neuroendocrine ADH Secretion Abnormality, CTCAE


Grade 2 Memory Impairment, CTCAE

description: Moderate memory impairment; limiting instrumental ADL


name: Grade 1 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 4 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Lymph Gland Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Anal Hidradenoma Papilliferum

description: A benign neoplasm arising from the perianal sweat glands. It presents as a cystic nodular lesion and is characterized by the presence of cystic and papillary structures. The papillary structures contain connective tissue and are covered by two layers of epithelium.


Metastatic Low Grade Astrocytoma

description: Low grade astrocytoma that has spread from its primary site to another anatomic site.


name: Clonal Monocytosis of Undetermined Significance

description: A myelodysplastic/myeloproliferative neoplasm characterized by the presence of persistent monocytosis, presence of at least one myeloid neoplasm-associated mutation, absence of significant dysplasia or increased blasts in the bone marrow, absence of morphologic findings suggestive of chronic myelomonocytic leukemia in the bone marrow, and absence of history of a reactive condition that would explain the persistent monocytosis.


name: Grade 3 Gastrointestinal Stoma Hemorrhage, CTCAE


Grade 1 Urostomy Site Bleeding, CTCAE

description: Minimal bleeding identified on clinical exam; intervention not indicated


Recurrent Vulvar Carcinoma

description: The reemergence of vulvar carcinoma after a period of remission.


name: Grade 4 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Acute Kidney Injury, CTCAE

description: Life-threatening consequences; dialysis indicated


Grade 2 Peripheral Ischemia, CTCAE

description: Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit


Heart Failure, CTCAE

description: A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure.


name: Pathologic Stage 0 Merkel Cell Carcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: In situ primary tumor. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Grade 4 Anus Stricture or Stenosis, CTCAE


name: Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Atrial Flutter, CTCAE

description: Death


name: Grade 5 Urethra Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Kidney Intra-Operative Injury, CTCAE


Grade 2 Postnasal Drip, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Hodgkin's disease lymphocyte depletion type recurrent

description: The reemergence of lymphocyte-depleted classic Hodgkin lymphoma after a period of remission.


Stage IB1 Cervical Cancer AJCC v9

description: Stage IB1 includes: T1b1, N0, M0. T1b1: Tumor measuring more than 5 mm in depth and equal or less than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Gemistocytic Astrocytoma, IDH-Mutant

description: Gemistocytic astrocytoma carrying IDH mutations.


name: Grade 1 Central Nervous System Hemorrhage, CTCAE


name: Pathologic Stage IV Merkel Cell Carcinoma AJCC v8

description: Stage IV includes: T0-4, Any N, M1. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. M1: Distant metastasis microscopically confirmed. (AJCC 8th ed.)


name: Grade 1 Cervix Intra-Operative Injury, CTCAE


Grade 1 Anal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 3 Bronchus Intra-Operative Injury, CTCAE


name: Grade 4 Pituitary Intra-Operative Injury, CTCAE


Vaginal Papillary Carcinoma

description: A rare squamous cell carcinoma that arises from the vagina resembling transitional cell carcinoma of the urinary tract.


name: Refractory Fallopian Tube Transitional Cell Carcinoma

description: Fallopian tube transitional cell carcinoma that is resistant to treatment.


Grade 4 Obstruction Gastric, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Localized Malignant Solid Neoplasm

description: A malignant solid neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


name: Metabolism and Nutrition Disorders - Other, Specify, CTCAE


name: Grade 4 Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Serum Immunoglobulin Free Light Chain Increased

description: A laboratory test result indicating higher than normal levels of immunoglobulin free light chain in the serum.


name: Grade 5 Respiratory Tract Hemorrhage NOS, CTCAE


name: Grade 5 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Cholesterol High, CTCAE

description: >ULN-300 mg/dL; >ULN-7.75 mmol/L


name: Grade 5 Cytomegalovirus Infection Reactivation, CTCAE

description: Death


Stage II Bladder Cancer AJCC v8

description: Stage II includes: (T2a, N0, M0); (T2b, N0, M0). T2a: Tumor invades superficial muscularis propria (inner half). T2b: Tumor invades deep muscularis propria (outer half). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Idiopathic Ketotic Hypoglycemia

description: Ketotic hypoglycemia that usually occurs in young, thin children in association with infection or fasting, and which typically resolves by age 6-8 years.


name: Esophageal Varices Hemorrhage, CTCAE 3.0


name: Stage IIIA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Rash Maculo-Papular, CTCAE

description: Macules/papules covering 10-30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL; rash covering > 30% BSA with or without mild symptoms


Grade 2 Oral Dysesthesia, CTCAE

description: Moderate pain; interfering with oral intake


Tubular Neoplasm

description: A benign or malignant neoplasm characterized by the presence of a tubular architecture. This category includes tubular adenomas and tubular carcinomas.


name: Lacrimal Drainage System Exophytic Papilloma

description: A benign exophytic papillary neoplasm that arises from the lacrimal drainage system. It consists of fibrovascular cores lined by epithelial cells.


Grade 2 Gastric Ulcer, CTCAE

description: Symptomatic; altered GI function; medical intervention indicated; limiting instrumental ADL


name: Abnormal Blood Chemistry and Hematology Test Result

description: A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values.


Grade 5 Ventricular Tachycardia, CTCAE

description: Death


name: Grade 4 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Hodgkin's disease mixed cellularity stage I subdiaphragmatic


name: Beta-2 Microglobulin Greater than 5.5 g/mL

description: A laboratory test result indicating the presence of high levels of beta-2 microglobulin in blood or urine, exceeding 5.5 g/mL.


Anal infection

description: An infectious process affecting the anal area.


Grade 1 Encephalopathy, CTCAE

description: Mild symptoms


name: Grade 4 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Reserve Cell Hyperplasia

description: Hyperplasia of the immature cells located between the surface columnar epithelium and the basal layer.


Grade 3 Pleural Hemorrhage, CTCAE

description: >1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2-4 hr); persistent transfusion indicated; elective operative intervention indicated; hospitalization


Physical Entrapment

description: Patient becomes entangled or caught in a bed, particularly in side rails, or mattress, or head/foot boards.


name: Hodgkin's Disease, Lymphocyte Depletion, Reticular

description: A lymphocyte depleted Hodgkin lymphoma characterized by the presence of reticular fibrosis.


name: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

description: Limited stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Restlessness, CTCAE

description: A disorder characterized by an inability to rest, relax or be still.


name: Neuroendocrine ADH Secretion Abnormality, CTCAE


Lacrimal Gland Acinic Cell Carcinoma

description: An extremely rare, low-grade, salivary gland-type carcinoma that arises from the lacrimal gland. It exhibits acinar differentiation.


name: Grade 2 Cranial Nerve V Neuropathy, CTCAE


Grade 2 Hypothyroidism, CTCAE

description: Symptomatic; thyroid replacement indicated; limiting instrumental ADL


Urethral Infection

description: A bacterial, viral, or fungal infectious process affecting the urethra.


Biliary Intraepithelial Neoplasia-2

description: Biliary intraepithelial neoplasia characterized by the presence of moderate epithelial atypia.


Recurrent Malignant Brain Neoplasm

description: The reemergence of a malignant brain neoplasm after a period of remission.


Abdominal Rhabdomyosarcoma

description: Rhabdomyosarcoma involving the organs and structures in the abdomen.


name: Large Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 1 Hallucinations, CTCAE

description: Mild hallucinations (e.g., perceptual distortions)


Injection site thrombophlebitis

description: Thrombophlebitis in the veins surrounding an injection site.


name: Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Accelerated phase chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.


Rare Diseases

description: A non-neoplastic or neoplastic disorder that is uncommon.


name: Microvascular Thrombosis Related to COVID-19

description: Blood clot formation in the small blood vessels of the body in a patient with probable or confirmed acute COVID-19.


name: Ann Arbor Stage II Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Grade 5 Ureteric Anastomotic Leak, CTCAE

description: Death


name: Grade 2 Alkaline Phosphatase Increased, CTCAE

description: >2.5-5.0 x ULN if baseline was normal; >2.5-5.0 x baseline if baseline was abnormal


Prosthetic Valve Thrombosis

description: The formation of a blood clot that is attached to or near an artificial heart valve; this can cause dysfunction of the valve, and possibly lead to an embolic event should the thrombus become dislodged.


Grade 3 Postoperative Hemorrhage, CTCAE

description: Transfusion indicated of >=2 units (10 cc/kg for pediatrics) pRBCs; invasive intervention indicated; hospitalization


Vulvar Dysplastic Melanocytic Nevus

description: A rare, elevated and pigmented, compound or junctional nevus that arises from the vulva. It affects women in their reproductive years and may be associated with the presence of dysplastic nevi in other anatomic areas. It is characterized by the presence of epithelioid or spindle-shaped melanocytes exhibiting nuclear pleomorphism and prominent nucleoli.


Grade 4 Conjunctivitis, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


name: Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


name: Grade 5 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Hepatitis B Reactivation, CTCAE

description: Life-threatening consequences; urgent intervention indicated; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)


name: Borderline Ovarian Serous Papillary Cystic Tumor

description: A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations of atypical serous epithelial cells and a cystic component.  There is no evidence of stromal invasion.


Vaginal Perforation, CTCAE 5.0

description: A disorder characterized by a rupture in the vaginal wall.


name: Grade 3 Upper Extremity Vein Intra-Operative Injury, CTCAE


Unresectable Malignant Gastric Neoplasm

description: A malignant gastric neoplasm that is not amenable to surgical resection.


Pain of Skin, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the skin.


name: Grade 3 Eye NOS Intra-Operative Injury, CTCAE


name: Grade 3 Intraoperative Head and Neck Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


name: Grade 1 Non-Malignant Pleural Effusion, CTCAE


Grade 3 Oral Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


Grade 4 Splenic Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Invasive Bladder Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive bladder urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Metastatic NUT Carcinoma

description: NUT carcinoma that has spread from its original site of growth to another anatomic site.


Peritoneal Sarcomatosis

description: A condition in which a sarcoma has spread extensively throughout the peritoneum.


Vaginal Infection, CTCAE

description: A disorder characterized by an infectious process involving the vagina.


name: Grade 3 Biliary Tree Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Hemolysis, CTCAE

description: A disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction.


Dehiscence

description: A splitting open of an anatomical structure, zone, or organ with the exposure or discharge of its content.


Grade 5 Ileal Fistula, CTCAE

description: Death


name: Grade 2 Cranial Nerve IX Neuropathy, CTCAE


Diffuse Midline Glioma, H3 K27-Altered

description: A diffuse midline glioma characterized by H3 K27 alteration and usually either a histone H3 K27M mutation, an EGFR mutation, or aberrant overexpression of EZHIP. The prognosis is poor.


Refractory WHO Grade 2 Glioma

description: WHO grade 2 glioma that is resistant to treatment.


name: Grade 5 Upper Aerodigestive Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Cecum Intra-Operative Injury, CTCAE


name: Metastatic Bladder Plasmacytoid Urothelial Carcinoma

description: Bladder plasmacytoid urothelial carcinoma that has spread to another anatomic site.


Grade 2 Gait Disturbance, CTCAE

description: Moderate change in gait (e.g., wide-based, limping or hobbling); assistive device indicated; limiting instrumental ADL


name: IgM Monoclonal Gammopathy of Undetermined Significance, Plasma Cell Type

description: A subtype of IgM monoclonal gammopathy of undetermined significance characterized by the presence of clonal plasma cells, absence of clonal B-lymphocytes, and absence of MYD88 gene mutation. The t(11;14)(q13;q32) is present in some cases. This subtype is considered a precursor of multiple myeloma.


Small Intestine Ulcer, CTCAE

description: A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the small intestine.


name: Unresectable Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and is not amenable to surgical resection.


name: Grade 2 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Chest Pain in Right Second Intercostal Space

description: The location of the chest pain is within the second intercostal space on the right side.


Non-Neoplastic Mediastinal Disorder

description: A non-neoplastic disorder that affects the structures of the mediastinum.  Representative examples include mediastinitis and thymic hyperplasia.


Grade 5 Hyperthyroidism, CTCAE

description: Death


name: Grade 4 Left Ventricular Systolic Dysfunction, CTCAE

description: Refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated


name: Grade 1 Fibrosis-Deep Connective Tissue, CTCAE


Grade 5 Hypocalcemia, CTCAE

description: Death


Grade 3 Tremor, CTCAE

description: Severe symptoms; limiting self care ADL


Chills, CTCAE

description: A disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever.


Hair Color Changes, CTCAE

description: A disorder characterized by change in hair color or loss of normal pigmentation.


Childhood Digestive System Neoplasm

description: A neoplasm that affects any part of the digestive system and occurs during childhood.


Mixed Trophoblastic Tumor

description: A gestational trophoblastic tumor characterized by the presence of two or three histological types of gestational trophoblastic tumor, including choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor.


name: Grade 3 Infertility and Sterility, CTCAE


Stage 0 Gallbladder Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Neuropathy, Recurrent, with Pressure Palsies

description: An autosomal dominant condition caused by mutation(s) in the PMP22 gene, encoding peripheral myelin protein 22. Neuropathy is precipitated by mechanical compression on a nerve, typically with onset in the first and second decades.


name: Grade 4 Upper Extremity Artery Injury, CTCAE


name: Grade 4 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Vomiting, CTCAE

description: Death


Stage III Merkel Cell Carcinoma AJCC v7

description: Stage III includes: IIIA: (Any T, N1a, M0) and IIIB: (Any T, N1b/N2, M0).  N1a: Micrometastasis in regional lymph nodes.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Stage IIA Gallbladder Cancer AJCC v8

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 5 Infections and Infestations - Other, Specify, CTCAE

description: Death


Fibrohistiocytic Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern.


name: Grade 1 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Skin Intra-Operative Injury, CTCAE


Stage IIB Cervical Cancer AJCC v9

description: Stage IIB includes: T2b, N0, M0. T2b: Tumor with parametrial invasion but not up to the pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Unresectable Sarcoma

description: A sarcoma which is not amenable to surgical resection.


Grade 3 Hepatic Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Decreased NCF1 Expression

description: An indication that the expression of NCF1 is lower than the normal range of values.


Grade 4 Infant Irritability, AE

description: An adverse event in a newborn characterized by life threatening irritability, with loss of autonomic control of temperature or heart rate; requiring urgent care change.


name: Smoldering Systemic Mastocytosis with an Associated Myeloid Neoplasm

description: Smoldering systemic mastocytosis associated with the presence of a clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome,  myeloproliferative neoplasm, and acute myeloid leukemia).


name: Human papillomavirus negative squamous cell carcinoma

description: A squamous cell carcinoma not associated with human papilloma virus infection.


Stage II Cervical Cancer AJCC v6

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0). T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Grade 3 Small Intestinal Perforation, CTCAE

description: Invasive intervention indicated


name: Grade 2 Cranial Nerve IV Neuropathy, CTCAE


name: Grade 3 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Jejunal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Recurrent Anal Mucinous Adenocarcinoma

description: The reemergence of anal mucinous adenocarcinoma after a period of remission.


Prostate Cancer by AJCC v7 Stage

description: A term that refers to the staging of prostate carcinoma according to the American Joint Committee on Cancer, 7th edition.


PALB2-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in the PALB2 gene. This mutation is associated with the development of breast carcinoma and pancreatic carcinoma.


Maternal Proteinuria

description: The presence of excessive protein, chiefly albumin but also globulin, in the urine of a pregnant woman.


Grade 1 Renal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Liver Neuroendocrine Tumor G1

description: A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is less than 2 per 10 HPF.


Rare Malignant Solid Neoplasm

description: A malignant solid neoplasm with an annual incidence of less than 6 per 100,000 people.


name: Pancreatic Moderately Differentiated Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures.


name: Steroid-Dependent Gastrointestinal Tract Acute Graft Versus Host Disease

description: Gastrointestinal tract acute graft versus host disease that is responsive to treatment with steroids but relapses during attempts at tapering or discontinuing steroid therapy.


Grade 3 Tumor Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Cervix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Paresthesia, CTCAE

description: A disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and/or warmth.


Grade 1 Neonatal Convulsion, AE

description: An adverse event in a newborn characterized by a single, self-limited suspected seizure requiring no treatment.


name: Grade 2 Gastroesophageal Reflux Disease, CTCAE

description: Moderate symptoms; medical intervention indicated


Grade 3 Hypercalcemia, CTCAE

description: Corrected serum calcium of >12.5-13.5 mg/dL; >3.1-3.4 mmol/L; Ionized calcium >1.6-1.8 mmol/L; hospitalization indicated


Esophageal Cancer by AJCC v7 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Grade 5 Uterine Hemorrhage, CTCAE

description: Death


name: Personality and Behavioral Change, CTCAE


Type I Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to endometrioid adenocarcinoma and mucinous adenocarcinoma.


name: Grade 4 Carotid Artery Intra-Operative Injury, CTCAE


Stage 0 Vulvar Cancer AJCC v6

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Low Grade Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Retention cyst

description: A cyst that is formed because of the blockage of the duct of a glandular organ. This results in the retention of the glandular secretions.


Grade 1 Colonic Ulcer, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Hemolytic disease of fetus OR newborn due to ABO immunization

description: A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of anti-A or anti-B antibodies from a mother to the child via the placenta against A or B antigens of the newborn's blood.


name: Pancreas Exocrine Enzyme Deficiency, CTCAE


name: Prostate Carcinoma Metastatic in the Soft Tissue

description: A carcinoma that arises from the prostate gland and has spread to the soft tissues.


name: Grade 2 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Hyperphosphatemia, CTCAE

description: Laboratory finding only and intervention not indicated


name: Death Not Associated with More Specific Term NOS, CTCAE


Grade 3 Wound Complication, CTCAE

description: Operative intervention indicated


name: Metastatic malignant neoplasm to viscera

description: A malignant neoplasm which has spread from its original site of growth to any visceral site.


name: Grade 2 Non-Infectious Wound Complication, CTCAE


Grade 1 Pulmonary Fibrosis, CTCAE

description: Radiologic pulmonary fibrosis <25% of lung volume associated with hypoxia


Tracheal Obstruction, CTCAE

description: A disorder characterized by blockage of the lumen of the trachea.


name: Cytogenetically normal acute myeloid leukemia

description: Acute myeloid leukemia not associated with cytogenetic abnormalities.


Adenocarcinoma in tubulovillous adenoma

description: A non-invasive or invasive adenocarcinoma arising from a tubulovillous adenoma.


Grade 4 Tracheal Obstruction, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Orthokeratinized odontogenic cyst

description: An odontogenic cyst that is entirely or predominantly lined by orthokeratinized stratified squamous epithelium. (WHO 2017)


Breast Solid Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the breast.  It is characterized by the presence of cellular solid nests and trabeculae that contain spindle-shaped, plasmacytoid, and large neuroendocrine cells.


name: Grade 1 Tracheostomy Site Bleeding, CTCAE

description: Minimal bleeding identified on clinical exam; intervention not indicated


Grade 3 Facial Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 3 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Primary Meningeal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the leptomeninges. This category includes diffuse proliferative processes (melanocytosis and melanomatosis) and circumscribed processes (melanocytoma and melanoma).


name: Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8

description: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Grade 3 Edema Trunk, CTCAE

description: Gross deviation from normal anatomic contour; limiting self care ADL


name: Carbon Monoxide Diffusing Capacity Decreased, CTCAE

description: A finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide.


name: Grade 4 Cranial Nerve I Neuropathy, CTCAE


Anal Inflammatory Cloacogenic Polyp

description: A non-neoplastic polypoid lesion that arises from the anal transitional zone.  It is characterized by the presence of hyperplastic rectal mucosa that is partially covered by squamous or transitional epithelium.


name: Grade 4 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Hypoxic Ischemic Encephalopathy, AE

description: An hypoxic ischemic encephalopathy adverse event in a newborn which results in death.


name: Peritoneal and retroperitoneal disorders

description: A non-neoplastic or neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Grade 3 Obesity, CTCAE

description: BMI 30-39.9 kg/m2


Stage IIB Cervical Cancer AJCC v8

description: Stage IIB includes: T2b, Any N, M0. T2b: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina with parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


name: Life Threatening or Disabling Adverse Event

description: Any adverse event that places the patient, in the view of the initial reporter, at immediate risk of death from the adverse event as it occurred, i.e., it does not include an adverse experience that, had it occurred in a more severe form, might have caused death.


Single Ventricle Defect

description: A diverse group of congenital cardiovascular abnormalities that share one characteristic, the presence of a single functional cardiac ventricle.


name: Grade 4 Retroperitoneal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Non-Neoplastic Digestive System Disorder

description: A non-neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. Representative examples include infections, ulcers, cirrhosis, and diverticulosis.


name: Grade 4 Neutrophils and Granulocytes, CTCAE


Pancreas Infection, CTCAE

description: A disorder characterized by an infectious process involving the pancreas.


name: Grade 3 Heart Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Hepatitis B Reactivation, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Vaginal Stenosis and Length, CTCAE


Second Primary Tumor

description: A new primary neoplasm that occurs in a person who was previously diagnosed with another primary neoplasm.


name: Infiltrating Ureter Urothelial Carcinoma with Mixed Differentiation


Metastatic non-small cell carcinoma

description: Non-small cell carcinoma that has spread from its original site of growth to another anatomic site.


Malignant Visual Pathway Neoplasm

description: A primary or metastatic malignant neoplasm that affects the visual pathway.


Grade 3 Dermatitis Radiation, CTCAE

description: Moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion


Grade 4 Jejunal Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Metastatic Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread to another anatomic site.


name: Grade 4 Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Grade 2 Cervicitis Infection, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Firearm Injury

description: An injury sustained by a gun.


Sternotomy Scar

description: Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where a vertical inline incision is made along the sternum, after which the sternum itself is divided. (ACC/AHA)


name: Grade 5 Meninges Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Outer Ear NOS Intra-Operative Injury, CTCAE


name: Refractory Histiocytic and Dendritic Cell Neoplasm

description: A histiocytic and dendritic cell neoplasm that does not respond to treatment.


Stage IIC Merkel Cell Carcinoma AJCC v7

description: Stage IIC includes: T4, N0, M0.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Nail Matrix Nevus

description: An acral nevus that arises from the nail matrix.


Myeloid Neoplasm with Mutated TP53

description: Myeloid neoplasm characterized by the presence of TP53 gene mutations. This category includes myelodysplastic syndrome, myelodysplastic syndrome/acute myeloid leukemia, and acute myeloid leukemia with mutated TP53.


name: Grade 1 Larynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Death Due to Multi-Organ Failure Not Associated with More Specific Term, CTCAE


name: Lugano Classification Stage II Childhood Hodgkin Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Cutaneous Juvenile Xanthogranuloma

description: A benign histiocytic tumor that arises from the skin and occurs during childhood; it is distinct from Langerhans cell histiocytosis. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells in the dermis. The lesions usually develop during infancy. They consist of cutaneous papules and nodules (most often in the head and neck).


Grade 1 Edema Face, CTCAE

description: Localized facial edema


name: Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Epilepsy congenital

description: A seizure disorder that is present at the time of birth.


name: Stage IIIA Cervical Cancer AJCC v6 and v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Grade 1 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Hematosalpinx, CTCAE

description: A disorder characterized by the presence of blood in a fallopian tube.


name: Grade 2 Leukoencephalopathy Radiographic Findings, CTCAE


name: Grade 3 Rash Hand or Foot Skin Reaction, CTCAE


Grade 2 Enterocolitis Infectious, CTCAE

description: Passage of >3 unformed stools per 24 hrs or duration of illness >48 hrs; moderate abdominal pain; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Injury to spleen with open wound into cavity

description: Trauma to the spleen associated with a break in the tissue that extends into the abdominal cavity.


name: Grade 3 Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Cytomegalovirus Infection Reactivation, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


Chemically Induced Cytotoxicity

description: The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.


name: Grade 2 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Appendix Tubulovillous Adenoma

description: An adenoma arising from the appendix.  It is characterized by the presence of tubular and villous epithelial structures and it is associated with dysplasia.


Favorable Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis.


Unspecified dermatitis due to sun

description: Inflammation of the skin resulting from exposure to the sun.


Gastric Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the gastric wall.


Hyperkalemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.


name: Grade 5 Genitourinary Stoma Obstruction, CTCAE


name: Intraoperative Head and Neck Injury, CTCAE

description: A finding of damage to the head and neck during a surgical procedure.


Stage III Testicular Cancer AJCC v8

description: Stage III includes: Any pT/TX, Any N, M1, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. M1: Testicular cancer with distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Benign Musculoskeletal Neoplasm

description: A mesenchymal neoplasm that arises from muscle or bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 2 Pelvis NOS Intra-Operative Injury, CTCAE


Grade 5 Febrile Neutropenia, CTCAE

description: Death


name: Acute Myeloid Leukemia with t(5;17)(q35;q21); NPM1-RARA

description: Acute myeloid leukemia with the variant RARA t(5;17)(q35;q21) and the expression of NPM1-RARA fusion protein.


name: Vaginal intraepithelial neoplasia grade 1

description: Vaginal intraepithelial neoplasia characterized by the presence of koilocytosis and disorganization and thickening of the basal layer.


Hyperpigmentation, CTCAE

description: An adverse reaction characterized by darkening of the skin.


Grade 1 Virilization, CTCAE

description: Mild symptoms; intervention not indicated


Grade 4 Hypermagnesemia, CTCAE

description: >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences


name: Localized Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that is restricted to the site of origin without evidence of metastasis.


name: Pulmonary and Upper Respiratory Hemorrhage, CTCAE


name: Grade 1 Vulva Intra-Operative Injury, CTCAE


name: Grade 5 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Spermatic Cord Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Grade 2 Bladder Intra-Operative Injury, CTCAE


Grade 4 Depression, CTCAE

description: Life-threatening consequences, threats of harm to self or others; hospitalization indicated


name: Recurrent Malignant Endocervical Neoplasm

description: The reemergence of a malignant neoplasm of the endocervix after a period of remission.


name: Grade 3 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage IA Gestational Trophoblastic Tumor AJCC v7

description: Stage IA includes: T1, M0, Risk factors: low risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Grade 4 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Sclerodermatous Graft Versus Host Disease

description: A rare form of chronic graft-versus-host disease characterized by cutaneous features and/or mucocutaneous features including sclerosis, atrophy, and contractures. It may manifest as localized or generalized disease.


Chronic Myelomonocytic Leukemia-1

description: A chronic myelomonocytic leukemia characterized by the presence of less than 10 percent blasts in the bone marrow and less than 5 percent blasts in the peripheral blood.


name: Stage 0 Gallbladder Cancer AJCC v6 and v7

description: Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Differentiated Granulocytic Sarcoma

description: A granulocytic sarcoma composed of promyelocytes and more mature neutrophils (WHO 2001).


name: Malignant mesothelioma of tunica vaginalis

description: A rare malignant mesothelioma that arises from the tunica vaginalis.


name: Grade 2 Testes Stricture or Stenosis, CTCAE


name: Grade 3 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Burn, CTCAE

description: Moderate to major debridement or reconstruction indicated


Celosomy

description: A developmental abnormality characterized by the complex protrusion of viscera outside the abdominal wall.


Phobia, School

description: An overwhelming, irrational, and persistent fear of attending school.


Grade 2 Uterine Obstruction, CTCAE

description: Symptomatic; elective intervention indicated


Grade 5 Injury To Jugular Vein, CTCAE

description: Death


name: squamous cell carcinoma of urinary tract

description: A rare squamous cell carcinoma that arises from the urinary tract. Almost all cases have been reported in the bladder. Causes include urinary stasis, recurrent chronic inflammation, and smoking. In regions where schistosomiasis is endemic, it is the major etiologic factor of bladder squamous cell carcinoma.


name: Grade 1 International Normalized Ratio of Prothrombin Time, CTCAE


Grade 1 Cognitive Disturbance, CTCAE

description: Mild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated


Grade 3 Tracheitis, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Diffuse Mixed-Cell Lymphoma

description: An antiquated term referring to non-Hodgkin lymphomas with a mixed cellular composition. This term applies to both B- and T- cell non-Hodgkin lymphomas.


Grade 1 GGT Increased, CTCAE

description: >ULN-2.5 x ULN if baseline was normal; 2.0-2.5 x baseline if baseline was abnormal


name: Grade 1 Muscle Weakness Left-Sided, CTCAE

description: Symptomatic; perceived by patient but not evident on physical exam


name: Grade 3 Catheter Related Infection, CTCAE


name: Grade 3 Blood Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 4 Pancreatic Endocrine Glucose Intolerance, CTCAE


Agonizing Pain

description: A sensation of great anguish and suffering.


name: Recurrent Cervical Squamous Cell Carcinoma

description: The reemergence of cervical squamous cell carcinoma after a period of remission.


name: Intrahepatic Bile Duct Microcystic Adenoma

description: An adenoma that arises from the intrahepatic bile ducts and it is characterized by the presence of microcystic changes.


name: Grade 3 Cervical Spine Range of Motion, CTCAE


Refractory WHO Grade 3 Glioma

description: A WHO grade 3 glioma that is resistant to treatment.


Non-Hematologic Malignancy

description: A malignant neoplasm that arises from a site other than the bone marrow and lymphoid tissue.


name: Metastatic Micropapillary Urothelial Carcinoma

description: Micropapillary urothelial carcinoma that has spread to another anatomic site.


name: Pathologic Stage II Cutaneous Melanoma AJCC v8

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage IC Fallopian Tube Cancer AJCC v8

description: Stage IC includes: T1c, N0, M0. T1c: Fallopian tube cancer with tumor limited to fallopian tubes, with any of the following: surgical spill, capsule ruptured before surgery or tumor on fallopian tube surface, or malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic gastric adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Endometrial Endometrioid Adenocarcinoma with Small Glands, Tubules or Cords


Unresectable Vulvar Carcinoma

description: Vulvar carcinoma that is not amenable to surgical resection.


name: Grade 3 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Stage I Gastric Cancer AJCC v6

description: Stage I includes: IA: (T1, N0, M0) and IB: (T1, N1, M0); (Ta/b, N0, M0).  T1: Tumor invades lamina propria or submucosa.  T2: Tumor invades the muscularis propria or the subserosa.  T2a: Tumor invades muscularis propria. T2b: Tumor invades subserosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Dysesthesia, CTCAE

description: A disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation.


Esophageal Mass

description: An abnormal growth located in the esophagus.


name: Grade 4 Spinal Cord Intra-Operative Injury, CTCAE


name: Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage I Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 1 cm or less and is confined within the sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Neuronevus

description: An intradermal nevus characterized by the presence of nests of atrophic nevus cells which are hyalinized and resemble nerve bundles.


Superior Vena Cava Syndrome, CTCAE

description: A disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.


Late effect of radiation

description: Late radiation injury (LRI) is the damage to the soft tissue and bone following radiation therapy that occurs weeks and years after the radiation exposure. Pathogenesis of LRI stems from ischemia, interruption of the blood supply and direct cell damage. LRIs include but not limited to the skin atrophy, ulceration and non-healing wounds; cystitis, proctosigmoiditis, resulting to fistulas, abscesses, fibrosis and scaring; laryngitis, osteoradionecrosis; central nervous system injury, optic neuropathy.


MGMT-Unmethylated Glioblastoma

description: A glioblastoma characterized by the absence of DNA methylation in the promoter region of the MGMT gene. It is associated with a poor outcome.


Shunt thrombosis

description: The presence of a thrombus within a vascular shunt.


name: Grade 3 Thrombotic Thrombocytopenic Purpura, CTCAE

description: Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)


name: Benign Peritoneal and Retroperitoneal Neoplasm

description: A neoplasm that arises from the peritoneum and/or retroperitoneum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 4 Ileus, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Metastatic Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


name: Localized Childhood Astrocytoma by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIA Bladder Cancer AJCC v8

description: Stage IIIA includes: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 2 Lymphocyte Count Increased, CTCAE


Moderate Grade Fever

description: Body temperature ranging between 102.1 degrees Fahrenheit (39 degrees Celsius) and 103.9 degrees Fahrenheit (39.9 degrees Celsius).


name: Agoraphobia without history of panic disorder

description: An anxiety disorder characterized by agoraphobia in the absence of a history of panic attacks; the individual fears incapacitation or humiliation in open, public places or situations due to panic-like symptoms rather than a full-blown panic attack.


name: Stage II Childhood Retinoblastoma by Toronto Guidelines v2

description: Enucleation with microscopic residual disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Alkaline Phosphatase Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen.


Grade 5 Colonic Obstruction, CTCAE

description: Death


name: Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal glandular epithelium.


Gingival Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the gingival region.


name: Grade 3 CNS Necrosis and Cystic Progression, CTCAE


Cervical Yolk Sac Tumor

description: A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina.


Grade 1 Guillain-Barre Syndrome, CTCAE

description: Mild symptoms


name: Grade 2 Supraventricular Arrhythmia NOS, CTCAE


Verruca Palmaris

description: A wart on the palmar surface of the hand. It is caused by human papillomavirus.


Anemia, CTCAE

description: A disorder characterized by a reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.


name: Pathologic Stage II Retinoblastoma AJCC v8

description: Stage II includes: pT4, pN0, cM0, Any H. pT4: Evidence of extraocular tumor: tumor at the transected end of the optic nerve, tumor in the meningeal spaces around the optic nerve, full-thickness invasion of the sclera with invasion of the episclera, adjacent adipose tissue, extraocular muscle, bone, conjunctiva, or eyelids. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Leukocytosis, CTCAE

description: A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood.


Grade 2 Bladder Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 4 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Accessory Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Recurrent Urethral Cancer

description: The reemergence of urethral carcinoma after a period of remission


name: Grade 3 Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Developmental and Epileptic Encephalopathy 44

description: An autosomal recessive subtype of developmental and epileptic encephalopathy caused by mutation(s) in the UBA5 gene, encoding ubiquitin-like modifier-activating enzyme 5.


Neuroendocrine carcinoma, metastatic

description: A neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


Mental disorder in childhood

description: A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence.


name: Myelodysplastic Syndrome, Unclassifiable, with Single Lineage Dysplasia

description: Myelodysplastic syndrome, unclassifiable characterized by unilineage dysplasia and associated pancytopenia.


Stage I Urethral Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Biliary Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Grade 3 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: malignant neoplasm of lacrimal apparatus

description: A primary or metastatic malignant neoplasm affecting the lacrimal gland or the lacrimal drainage system.


Recurrent Tectal Glioma

description: The reemergence of tectal glioma after a period of remission.


Grade 3 Vertigo, CTCAE

description: Severe symptoms; limiting self care ADL


name: Supratentorial Ependymoma, Not Elsewhere Classified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain, characterized by the absence of a fusion gene involving ZFTA or YAP1 genes.


Systemic disease

description: A clinical course finding indicating that a disease presents with systemic manifestations.


name: Grade 2 Inner Ear Intra-Operative Injury, CTCAE


name: Secondary Supratentorial Anaplastic Astrocytoma

description: An anaplastic astrocytoma occurring in the supratentorial area secondary to a preexisting tumor.


Neonatal Pulmonary Hemorrhage, AE

description: An adverse event in a newborn characterized by bleeding in the respiratory tract of a neonate.


neoplasm of corpus callosum

description: A benign or malignant neoplasm that affects the corpus callosum.


Grade 1 Agitation, CTCAE

description: Mild mood alteration


name: Steroid Refractory Graft Versus Host Disease

description: Graft versus host disease that does not respond to steroid treatment.


name: Lugano Classification Stage II Adult Hodgkin Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: Grade 2 Upper Extremity Soft Tissue Necrosis Adverse Event, CTCAE


name: Urinary Conduit Intra-Operative Injury, CTCAE


name: International Normalized Ratio of Prothrombin Time, CTCAE


Unsolicited Adverse Event

description: An adverse event that is voluntarily reported by a healthcare professional, consumer, or patient outside of an organized data collection system.


Desmoplastic trichoepithelioma

description: A benign adnexal tumor occurring in the face of young female subjects. It is characterized by the presence of epithelial neoplastic cells and keratinous cysts in a desmoplastic stroma.


Grade 5 Anorexia, CTCAE

description: Death


Grade 5 Hypophosphatemia, CTCAE

description: Death


name: Ampulla of Vater Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region.  It is characterized by the presence of malignant large cells.


Grade 3 Neonatal Epileptic Seizure, AE

description: An adverse event in a newborn characterized by electroencephalogram (EEG)-proven seizures uncontrolled with one anti-seizure drug (recurrence within three days after treatment or requiring two or more anti-seizure drugs).


Blastic Phase

description: Sudden increase of the number of blasts in the bone marrow and/or peripheral blood in a patient with a history of chronic leukemia.


name: Grade 5 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


Defective Heavy Chain Present

description: An indication that cells expressing a mutated or defective form of immunoglobulin heavy chain have been detected in a sample.


Pleuritic Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the pleura.


Locally Advanced Melanoma

description: Melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Thoracodorsal Nerve Intra-Operative Injury, CTCAE


name: Grade 4 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


Hereditary Paraganglioma

description: A hereditary neoplasm arising from paraganglia. The majority of cases (up to 80%) are multifocal. It is caused by mutations in SDHA, SDHB, SDHC, SDHD, and SDHAF2 genes.


name: Grade 4 Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Malignant Intracranial Germ Cell Tumor

description: A malignant germ cell tumor that affects the structures within the cranium.


name: Grade 1 Irritability in Children Less Than 3 Years of Age, CTCAE


Ascites, CTCAE

description: A disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity.


Grade 2 Malabsorption, CTCAE

description: Altered diet; oral intervention indicated


Secondary Plasma Cell Leukemia

description: Transformation of plasma cell myeloma to plasma cell leukemia.


name: Grade 1 Dental and Teeth and Peridontal Pain, CTCAE


name: Grade 4 Spermatic Cord Stricture or Stenosis, CTCAE


name: Grade 3 Portal Vein Intra-Operative Injury, CTCAE


Grade 3 Hemorrhoidal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


Central Nervous System Radiation Injury

description: Radiation injury of the central nervous system.


name: Grade 4 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Invasive Bladder Urothelial Carcinoma Associated with Urethral Carcinoma

description: Invasive urothelial carcinoma of the bladder which is associated with the presence of in situ or infiltrating urethral carcinoma.


name: Borderline Paratesticular Mucinous Tumor

description: A rare, non-invasive, mucinous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical mucinous epithelial cells. Metastases have not been reported.


Ataxia, CTCAE 5.0

description: A disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities.


name: Acute Myocardial Injury with Heart Failure Related to COVID-19

description: Acute myocardial injury with evidence of new or worsening signs and symptoms of heart failure in a patient with probable or confirmed acute COVID-19.


Vitreous Hemorrhage, CTCAE 5.0

description: A disorder characterized by bleeding into the vitreous humor.


Grade 4 Gastric Necrosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 3 Gallbladder Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Recurrent Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary large cell neuroendocrine carcinoma after a period of remission.


Grade 1 Tracheal Mucositis, CTCAE

description: Endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms


name: Grade 3 Radiation Excluding Chemoradiation, CTCAE


Flexural Skin Nevus

description: A benign nevus occurring in the flexural skin.


Anal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the anal region.


name: Grade 5 Catheter Related Infection, CTCAE

description: Death


name: Grade 3 Breast Nipple and Areolar Deformity, CTCAE


name: FIGO Grade 2 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains 6-50% non-squamous solid areas.


name: Grade 3 Liver Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Sinus Intra-Operative Injury, CTCAE


name: Grade 4 Pulmonary Artery Intra-Operative Injury, CTCAE


Hallucinations, CTCAE

description: A disorder characterized by a false sensory perception in the absence of an external stimulus.


Malignant mastocytosis

description: A group of malignant mast cell disorders including aggressive systemic mastocytosis, mast cell leukemia, mast cell sarcoma, and systemic mastocytosis with an associated myeloid neoplasm. Individuals with advanced systemic mastocytosis have a reduced life expectancy, with median survival measured in months to years.


name: Grade 4 Gamma-Glutamyl Transpeptidase, CTCAE


Acute Placental Infarction

description: A focus of necrotic placental parenchyma with clearly visible outlines of necrotic villous structures and absence of any hyalinization and fibrosis, which is frequently 1-2 days of duration.


Grade 4 Gastroparesis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Nasal Congestion, CTCAE

description: Mild symptoms; intervention not indicated


name: Recurrent Vaginal Squamous Cell Carcinoma

description: The reemergence of vaginal squamous cell carcinoma after a period of remission.


name: Grade 2 Ejection Fraction Decreased, CTCAE

description: Resting ejection fraction (EF) 50-40%; 10-19% drop from baseline


name: Grade 5 Soft Tissue Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


High Grade Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


Grade 1 Urostomy Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Intestinal Stoma Obstruction, CTCAE

description: Severe symptoms; IV fluids, tube feeding, or TPN indicated >=24 hrs; elective operative intervention indicated


name: Cerebellar Glioneuronal and Neuronal Tumors

description: Glioneuronal and neuronal tumors occurring in the cerebellum.


name: Grade 3 Spermatic Cord Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 5 Ventricular Arrhythmia NOS, CTCAE


name: Grade 4 Inferior Vena Cava Intra-Operative Injury, CTCAE


Radiation Induced DNA Damage

description: Damage to DNA caused by ionizing radiation.  Can cause base change mutations or strand breakage.


Anal Ulcer, CTCAE

description: A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the anal canal.


name: Mediastinum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


name: Temporal Lobe Pleomorphic Xanthoastrocytoma

description: A pleomorphic xanthoastrocytoma that arises from the temporal lobe of the brain.


name: Refractory Fallopian Tube Endometrioid Adenocarcinoma

description: Fallopian tube endometrioid adenocarcinoma that is resistant to treatment.


Grade 5 Hypernatremia, CTCAE

description: Death


name: Intermediate Osteoclastic Giant Cell-Rich Tumor of Bone

description: A benign but locally aggressive giant cell tumor that arises from the bone.


Stage IB Esophageal Cancer AJCC v7

description: Stage IB includes: For squamous cell carcinoma: (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Vas Deferens Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures).


Stage IV Esophageal Cancer AJCC v7

description: Stage IV includes: For squamous cell carcinoma: Any T, Any N, M1, Any G, Tumor location: Any.  For adenocarcinoma: Any T, Any N, M1, Any G. M1: Distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Tracheal Verrucous Carcinoma

description: An exophytic, warty, well differentiated, slow growing and non-metastasizing squamous cell carcinoma arising from the trachea.


name: Middle Ear Intra-Operative Injury, CTCAE


Rectal Mucositis, CTCAE

description: A disorder characterized by ulceration or inflammation of the mucous membrane of the rectum.


name: Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood ependymoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Grade 4 Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Cranial Nerve VI Intra-Operative Injury, CTCAE


Advanced Uterine Corpus Cancer

description: Uterine corpus cancer that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Intraoperative Splenic Injury, CTCAE

description: Primary repair of injured organ/structure indicated


Localized Pancreatic Adenocarcinoma

description: An adenocarcinoma that arises from the pancreas and has not spread to other anatomic sites.


Recurrent Malignant Lymphoid Neoplasm

description: The reemergence of a malignant lymphoid neoplasm after a period of remission.


Grade 1 Capillary Leak Syndrome, CTCAE

description: Asymptomatic


name: Grade 2 Neutrophil Count Decreased, CTCAE

description: <1500-1000/mm3; <1.5-1.0 x 10e9/L


name: Langerhans Cell Histiocytosis, Disseminated

description: Langerhans cell histiocytosis presenting with disseminated disease.


name: Grade 3 Urethra Stricture or Stenosis, CTCAE


Grade 5 Endocarditis Infective, CTCAE

description: Death


name: Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Ear and Labyrinth Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Teeth Intra-Operative Injury, CTCAE


Hyperhidrosis, CTCAE

description: A disorder characterized by excessive sweating.


Claudin-Low

description: A genetic profile indicating low expression of cellular tight junction proteins, including E-cadherin, which is often associated with triple-negative breast cancer and tumor-infiltrating lymphocytes.


Cerebrospinal Fluid Leakage, CTCAE

description: A disorder characterized by loss of cerebrospinal fluid into the surrounding tissues.


Grade 1 Skin Induration, CTCAE

description: Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)


name: Grade 4 Aorta Artery Intra-Operative Injury, CTCAE


Cutaneous Melanoma of the Extremity

description: A cutaneous melanoma that arises from the upper or lower extremity.


name: acute diastolic congestive heart failure

description: Acute congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


name: Myelodysplastic Syndrome, Unclassifiable, with 1 Percent Blasts

description: Myelodysplastic syndrome, unclassifiable characterized by refractory cytopenia with unilineage dysplasia or refractory cytopenia with multilineage dysplasia but with 1 percent blasts in the peripheral blood.


Hypermagnesemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood.


name: Fallopian Tube High Grade Serous Adenocarcinoma

description: A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.


name: Grade 3 Intraoperative Respiratory Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 2 Hemolysis, CTCAE

description: Evidence of hemolysis and >=2 g decrease in hemoglobin


name: Grade 5 Prolapse of Gastrointestinal Stoma, CTCAE


name: Outer Ear NOS Intra-Operative Injury, CTCAE


Urticaria, CTCAE

description: A disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins.


Grade 3 Corneal Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Occipital Diastasis

description: Birth trauma caused by excessive pressure to the suboccipital region of the skull resulting in separation of the occipital squama from the lateral or condylar parts of the occipital bone. It is a serious injury that may lead to subdural hemorrhage in the posterior fossa.


Medullary carcinoma

description: A term referring to medullary carcinomas which can develop in various anatomic sites such as the thyroid gland, breast, colon, rectum, and small intestine.


Non-Cardiac Chest Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the chest unrelated to a heart disorder.


name: Grade 5 Stoma Pulmonary Hemorrhage, CTCAE


Central line infection

description: An infectious process related to a central venous catheter.


Refractory Basal Cell Carcinoma

description: Basal cell carcinoma that is resistant to treatment.


name: Childhood Malignant Nervous System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the nervous system and occurs during childhood.


Adrenocortical hyperplasia

description: Congenital or acquired hyperplasia of the cells of the adrenal cortex.


Tremor, CTCAE 5.0

description: A disorder characterized by the uncontrolled shaking movement of the whole body or individual parts.


Mucous cyst

description: A mucous containing cyst arising from the minor salivary glands in the oral cavity.


Vaginal abscess

description: An abscess that is located in the vagina.


Grade 1 Biliary Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Malignant tumor of optic nerve

description: A primary or metastatic malignant neoplasm that affects the optic nerve.


Bacillary Peliosis

description: An infection that is caused by Bartonella henselae, which occurs primarily in immunocompromised persons; it is characterized by blood-filled cysts in the liver and spleen.


name: Multifocal nodular oncocytic hyperplasia of salivary gland

description: A rare lesion characterized by multiple non-neoplastic nodular proliferations composed of cells with abundant granular eosinophilic cytoplasm (oncocytes) and/or clear cytoplasm (clear cells) in one or both parotid glands. (WHO 2017)


COVID-19-Associated Myalgia

description: Myalgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Grade 5 Trachea Obstruction and Stenosis, CTCAE


name: Grade 4 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Vaginal Dryness, CTCAE 5.0

description: A disorder characterized by an uncomfortable feeling of itching and burning in the vagina.


Hemolytic Uremic Syndrome, CTCAE

description: A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.


Stage IIB Bone Cancer AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Placental Malformation

description: A non-neoplastic abnormality that affects the placenta. Representative examples include multi-lobed and bilobed placenta.


Childhood Infectious Disorder

description: An infectious disorder that occurs in childhood.


name: Grade 1 Lumbar Spine Range of Motion, CTCAE


White Blood Cell Decreased, CTCAE

description: A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.


name: Grade 4 Gastrointestinal Leak NOS, CTCAE


Grade 1 Mitral Valve Disease, CTCAE

description: Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging


name: Acute gonococcal infection, of upper genitourinary tract

description: A gonococcal infection of the upper urinary tract that is rapid in onset.


Lipidized Glioblastoma

description: A rare glioblastoma characterized by the presence of a predominant population of neoplastic cells with foamy cytoplasm.


Maternal Sepsis

description: A pathologic response to infection in a mother or pregnant woman.


name: Lugano Classification Advanced Stage Childhood Hodgkin Lymphoma AJCC v8

description: Advanced stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Stage IV Esophageal Adenocarcinoma AJCC v7

description: Stage IV includes: Any T, Any N, M1, Any G.  M1: Distant metastasis.  (AJCC 7th ed.)


Grade 3 Nail Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Chest Wall Mass

description: An abnormal growth in the chest wall.


name: Grade 5 Cranial Nerve IX Neuropathy, CTCAE


name: Endometrial Mucinous Adenocarcinoma, Gastric-Type

description: A rare mucinous adenocarcinoma arising from gastric metaplasia of the endometrium.


Grade 3 Akathisia, CTCAE

description: Severe restlessness or increased motor activity; limiting self care ADL


name: Adverse Event Associated with the Lymphatic System


Grade 1 Nail Discoloration, CTCAE

description: Asymptomatic; clinical or diagnostic observations only


Abnormal Growth Hormone

description: A laboratory test result which indicates abnormal levels of growth hormone in a biologic specimen.


Grade 1 Hypertriglyceridemia, CTCAE

description: 150 mg/dL-300 mg/dL; 1.71 mmol/L-3.42 mmol/L


Adult Anaplastic (Malignant) Meningioma

description: An anaplastic (malignant) meningioma occurring in adults.


Neonatal Listeriosis

description: A bacterial infection by Listeria monocytogenes in a newborn infant up to 28 days old.


Grade 3 Bronchopleural Fistula, CTCAE

description: Hospitalization; invasive intervention indicated


Grade 2 Esophageal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 3 Menorrhagia, CTCAE

description: Severe; transfusion indicated; operative intervention indicated (e.g., hysterectomy)


Hyperuricemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid.


name: Grade 4 Otitis Middle Ear Non Infectious, CTCAE


name: Grade 4 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Intraoperative Cardiac Injury, CTCAE

description: Death


Late effect of medical intervention

description: Any symptom or condition which is a result of a medical intervention but arises months or years after it.


Grade 4 Appendicitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Cutaneous Radiation Injury

description: Radiation injury of the skin.


name: Serous papillary cystic tumor of borderline malignancy

description: A low malignant potential cystic serous epithelial neoplasm arising from the ovary. Cases with identical morphology have been described arising from the peritoneum as well. It is characterized by an atypical epithelial proliferation and a papillary growth pattern. There is no evidence of destructive stromal invasion.


name: Stage I Appendix Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 2 Genitourinary Stoma Obstruction, CTCAE


name: Grade 4 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 1 Retinopathy of Prematurity, AE

description: An adverse event in a newborn characterized by zone 2 International Classification of Retinopathy of Prematurity (ICROP) stage 1 with or without plus disease; zone 2 ICROP stage 2 without plus disease; zone 3 any ICROP stage; no care changes indicated.


name: Grade 4 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Grade 5 Appendicitis, CTCAE

description: Death


Hyperkeratosis, CTCAE

description: A disorder characterized by a thickening of the outer layer of the skin.


name: Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Virus-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific virus as the causative agent.


name: Grade 5 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

description: Death


Grade 2 Pleural Hemorrhage, CTCAE

description: Symptomatic or associated with pneumothorax; chest tube drainage indicated


Grade 2 Rectal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 2 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Larynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Low Hemoglobin Level

description: A lower than average level of hemoglobin in a sample.


name: Grade 3 Anus Intra-Operative Injury, CTCAE


name: Oligometastatic Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that has metastasized to a limited number of sites.


Postpartum Obstetric Air Embolism

description: Presence of a large air bubble in the maternal vascular system which originated from a distant site during the postpartum period.


Grade 5 Esophageal Stenosis, CTCAE

description: Death


Bone Cancer by AJCC v7 Stage

description: A term that refers to the staging of bone cancer, following the rules of the TNM AJCC v7 classification system.


name: Grade 4 Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


Non-Neoplastic Heart Disorder

description: A non-neoplastic disorder that affects the heart and/or the pericardium.  Representative examples include congestive heart disease, endocarditis, and constrictive pericarditis.


Stage IB1 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and equal or less than 4 cm in maximum diameter. (FIGO 2009)


name: Grade 3 Small Intestinal Stenosis, CTCAE

description: Symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated


Radiating Chest Pain in Upper Sternum

description: The location of the radiating chest pain is in the upper portion of the sternum.


name: Grade 4 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Laryngeal Stenosis, CTCAE

description: Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)


Death by strangulation

description: Choking or arrest of respiration due to occlusion of the air passages; arrest of circulation in a part due to compression.


Grade 3 Pyramidal Tract Syndrome, CTCAE

description: Severe symptoms; limiting self care ADL


name: Precursor T-lymphoblastic lymphoma/leukemia stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Grade 4 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Low Grade Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic process characterized by the presence of mild dysplastic cytological changes which are usually present in the lower part of the squamous epithelium.  Representative examples include the low grade esophageal squamous intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial neoplasia.


name: Grade 4 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Lymphatic Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Vaginitis Not Due to Infection, CTCAE


Depressed Level of Consciousness, CTCAE

description: A disorder characterized by a decrease in ability to perceive and respond.


name: Grade 5 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Chest Pain Along Right Anterior Axillary Line

description: The location of the chest pain is along the anterior axillary line on the right side.


Radiating Chest Pain in Mid Sternum

description: The location of the radiating chest pain is in the middle portion of the sternum.


name: intestinal type adenocarcinoma of gallbladder

description: An adenocarcinoma that arises from the gallbladder.  It is characterized by the presence of neoplastic tubular glands lined by columnar cells or neoplastic glands lined by goblet cells.


Typhlitis, CTCAE 5.0

description: A disorder characterized by necrotizing enterocolitis in neutropenic patients.


Esophageal Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the esophageal wall.


name: Grade 4 Lower Extremity Intra-Operative Injury, CTCAE


Disorder of Androgen Synthesis

description: An enzyme deficiency in the androgen biosynthesis pathway, resulting in the underproduction of one or more androgens by the adrenal glands and/or gonads.


name: Grade 3 Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Diverticular Carcinoma of the Urinary Tract

description: A carcinoma that arises from a diverticulum in the urinary tract. Most histological subtypes of urinary tract carcinomas have been reported in urinary tract diverticula.


Grade 2 Perineal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 3 Bronchopulmonary Dysplasia, AE

description: An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen or positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for greater than 30% oxygen or positive pressure by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for greater than 30% oxygen and/or positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


name: Grade 2 Acoustic Nerve Disorder NOS, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Grade 4 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


Stage IA Vulvar Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Lesion measuring 2 cm or less, confined to the vulva and/or perineum, and with stromal invasion of 1.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 2 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Vulval Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Stage IIA Osteosarcoma AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Grade 2 Other Pulmonary and Upper Respiratory, CTCAE


Blurred Vision, CTCAE

description: A disorder characterized by visual perception of unclear or fuzzy images.


Stage I Prostate Cancer AJCC v6

description: Stage I includes: T1, N0, M0, G1.  T1: Tumor invades subepithelial connective tissue.  N0: No regional metastasis.  M0: No distant metastasis. G1: Well differentiated (slight anaplasia) (Gleason 2-4).  (AJCC 6th ed.)


name: Grade 4 Pyramidal Tract Dysfunction, CTCAE


name: Grade 3 Edema of the Trunk and Genital Area, CTCAE


name: Recurrent Sclerodermatous Graft Versus Host Disease

description: The reemergence of sclerodermatous graft versus host disease after a period of remission.


Malignant Solitary Fibrous Tumor

description: A malignant neoplasm of probable fibroblastic derivation. It is characterized by the presence of atypical round to spindle-shaped cells, increased cellularity, necrotic change and high mitotic activity.


Recurrent Dedifferentiated Liposarcoma

description: The reemergence of dedifferentiated liposarcoma after a period of remission.


name: Locally Advanced Primary Malignant Central Nervous System Neoplasm

description: A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 3 Anorexia, CTCAE

description: Associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated


Grade 2 Pulmonary Valve Disease, CTCAE

description: Asymptomatic; moderate regurgitation or stenosis by imaging


name: Injury to diaphragm without mention of open wound into cavity

description: Trauma to the diaphragm without indication of associated damage to the skin and other internal and external tissues.


Grade 3 Prostatic Obstruction, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 2 Superior Vena Cava Syndrome, CTCAE

description: Symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy)


name: Liver Dysfunction or Failure by Clinical Classification, CTCAE


Prostate Basal Cell Carcinoma

description: An invasive prostate carcinoma composed of prostatic basal cells.


Childhood Bone Hemangioma

description: A bone hemangioma that occurs during childhood.


name: Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils Absolute Neutrophil Count Less Than 1 X 10e9 per Liter, CTCAE


Recurrent Diffuse Glioma

description: The reemergence of a diffuse glioma after a period of remission.


name: Grade 3 Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

description: Severe skin changes (e.g., peeling, blisters, bleeding, fissures, edema, or hyperkeratosis) with pain; limiting self care ADL


name: Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE


name: Grade 5 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Myeloproliferative Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia characterized by the presence of a markedly elevated white blood cell count in the peripheral blood.


Immune-Mediated Coagulopathy

description: Disorders of coagulation caused by autoantibodies generated against native coagulation factors or therapeutically-administered hemostatic agents.


Mesenteric thrombosis

description: Formation of a blood clot (thrombus) in the lumen of a mesenteric vein or mesenteric artery.


name: Grade 4 Tongue Intra-Operative Injury, CTCAE


Grade 1 Flu Like Symptoms, CTCAE

description: Mild flu-like symptoms present


Grade 4 Colonic Obstruction, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 1 Upper Gastrointestinal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Optic Nerve Injuries

description: Injury to the optic nerve.


Stage IVB Cervical Cancer AJCC v9

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


name: Grade 4 Phantom Pain Associated with Missing Limb, CTCAE


name: Grade 2 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage I Low Grade Adult Non-Hodgkin's Lymphoma


Breast Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the breast.


name: Grade 2 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Lugano Classification Stage IE Adult Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Diffuse Astrocytoma, IDH-Wildtype

description: Diffuse astrocytoma lacking mutations in IDH1 or IDH2 genes.


Childhood Bone Sarcoma

description: A sarcoma that arises from the bone and occurs during childhood.


Infectious Meningoencephalitis

description: Inflammation of the meninges and brain caused by an infectious agent.