Stage III Bladder Cancer AJCC v8

description: Stage III includes: IIIA: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0); IIIB: (T1-T4a, N2, N3, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Temporal lobe sclerosis

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A neurological condition caused by scarring and degeneration of the temporal lobe. It is characterized by cognitive and behavioral symptoms, and focal epilepsy.


Grade 4 Hypercalcemia, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences


Proliferative retinopathy

description: Retinopathy characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness.


Grade 5 Duodenal Obstruction, CTCAE

description: Death


Neonatal aspiration of amniotic fluid

description: Inhalation of fluid from the amniotic sac into the lungs by the neonate.


name: Grade 3 Duodenum Stricture or Stenosis, CTCAE


name: Grade 4 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Childhood Perineurioma

description: A perineurioma that occurs during childhood.


Acquired postural kyphosis

description: Postural kyphosis, the cause of which is not present at birth.


Cardiac Troponin T Increased, CTCAE

description: A finding based on laboratory test results that indicate increased levels of cardiac troponin T in a biological specimen.


squamous cell papilloma of anal canal

description: A benign epithelial neoplasm that arises from the anal canal.  It is characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


name: Grade 5 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Rectal Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the rectal wall.


name: Refractory Fallopian Tube Undifferentiated Carcinoma

description: Fallopian tube undifferentiated carcinoma that is resistant to treatment.


name: Major Visceral Vein Intra-Operative Injury, CTCAE


name: Steroid Resistant Chronic Graft Versus Host Disease

description: Chronic graft versus host disease that is resistant to treatment with steroids.


Grade 2 Portal Vein Thrombosis, CTCAE

description: Intervention not indicated


name: Recurrent Epithelioid Malignant Peripheral Nerve Sheath Tumor

description: The reemergence of an epithelioid malignant peripheral nerve sheath tumor after a period of remission.


name: Grade 3 Bronchus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Gastrointestinal Stoma Obstruction, CTCAE


name: Grade 4 Nose Intra-Operative Injury, CTCAE


name: Grade 1 Intraoperative Endocrine Injury, CTCAE

description: Primary repair of injured organ/structure indicated


name: Stage II Gestational Trophoblastic Tumor AJCC v7

description: Stage II includes: (T2, M0, Risk factors: unknown); IIA (T2, M0, Risk factors: low risk); IIB (T2, M0, Risk factors: high risk).  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 1 Laryngeal Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Fallopian Tube Stricture or Stenosis, CTCAE


name: Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Skin Induration, CTCAE

description: Generalized; associated with signs or symptoms of impaired breathing or feeding


name: Grade 3 Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Anemia (mild)

description: Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%.


name: Grade 3 Cranial Nerve II Neuropathy, CTCAE


Grade 1 Rhinorrhea, CTCAE

description: Present


name: clear cell adenocarcinoma of urinary tract

description: An adenocarcinoma that arises from the urinary tract and is characterized by the presence of malignant cells with clear and eosinophilic cytoplasm arranged in tubulo-cystic, papillary, or solid growth patterns. It usually arises from the urethra but can also occur in the bladder. It predominantly affects females and usually has an aggressive clinical course.


Esophageal Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the esophageal region.


Grade 2 Jejunal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Grade 5 Mitral Valve Disease, CTCAE

description: Death


Stage I Childhood Large Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Intraocular Schwannoma

description: A benign schwannoma occurring in the eye.


Low LDH Level

description: A lower than average level of lactate dehydrogenase in a sample.


Recurrent Childhood Lymphoma

description: The reemergence of a childhood Hodgkin or non-Hodgkin lymphoma after a period of remission.


description: A pilomyxoid astrocytoma occurring in the hypothalamic-chiasmatic region.


Sudden Death NOS, CTCAE

description: An unexpected death that cannot be attributed to a CTCAE term associated with Grade 5.


Hypoglycemia, CTCAE

description: A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.


Relapsing classical Hodgkin lymphoma

description: The reemergence of classic Hodgkin lymphoma after a period of remission.


Borderline Fallopian Tube Serous Tumor

description: A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion.


name: Refractory Mature T-Cell and NK-Cell Neoplasm

description: Mature T-cell and NK-cell neoplasm that is resistant to treatment.


Grade 3 Memory Impairment, CTCAE

description: Severe memory impairment; limiting self care ADL


name: Stage IVB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Rhesus hemolytic disease of newborn

description: A disorder caused when there is a Rh-factor blood-type incompatibility between the mother and fetus, and the mother's immune system forms antibodies that attack the red blood cells of her unborn child. This disorder can only occur if the mother is Rh-negative and the fetus is Rh-positive.


name: Grade 3 Pancreatic Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 1 Proptosis and Enophthalmos, CTCAE


name: Recurrent High Grade Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial high-grade endometrioid adenocarcinoma after a period of remission.


Old myocardial infarction

description: Documented history of previous myocardial infarction (MI), typically with objective evidence via positive biomarkers of myocardial necrosis.


Acquired macrocephaly

description: A non-congenital condition in which the head circumference is two standard deviations greater than the mean. Causes include infection, intraventricular hemorrhage, subdural hematoma, and arachnoid cysts.


Infective cervicitis

description: An infectious process affecting the uterine cervix. Causative agents include Neisseria gonorrhoeae, Chlamydia trachomatis, human papillomavirus, and herpes simplex virus. Physical examination reveals an erythematous, raised lesion in the cervix and mucopurulent discharge.


name: Grade 3 Other Blood and Bone Marrow, CTCAE


name: Grade 3 Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Crypt abscess (morphologic abnormality)

description: Accumulation of polymorphonuclear neutrophils in the mucosal crypts of the colon. It occurs in ulcerative colitis.


Grade 3 Dysmenorrhea, CTCAE

description: Severe symptoms; limiting self care ADL


Intraductal Hyperplasia

description: A hyperplasia of the intraductal cells.


name: Grade 5 Investigations - Other, Specify, CTCAE

description: Death


name: Invasive Sarcomatoid Urothelial Carcinoma

description: An invasive urothelial carcinoma that exhibits spindle cell sarcomatoid features.


Grade 2 Budd-Chiari Syndrome, CTCAE

description: Medical management indicated


name: Grade 1 Pulmonary Vein Intra-Operative Injury, CTCAE


name: Grade 5 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

description: Death


Grade 1 Anal Mucositis, CTCAE

description: Asymptomatic or mild symptoms; intervention not indicated


Hypersexualism

description: Excessive sexual behavior.


name: Grade 2 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Cranial Nerve XII Neuropathy, CTCAE


Refractory Acute Leukemia

description: Acute leukemia that does not respond to treatment.


name: Alcohol Related Neurodevelopmental Disorder

description: A cognitive and neurological disorder due to fetal intrauterine exposure to maternal alcohol consumption. Typically, this presents without facies or other growth abnormalities.


Herpes Simplex Reactivation, CTCAE

description: A disorder characterized by the reactivation of Herpes simplex virus


Grade 1 Gastric Ulcer, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Stomach Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


High Grade Endometrial Carcinoma

description: A group of aggressive endometrial carcinomas with high-grade histological features. It includes high grade endometrial endometrioid adenocarcinoma, endometrial clear cell adenocarcinoma, endometrial serous adenocarcinoma, and endometrial undifferentiated carcinoma.


name: Grade 2 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


Grade 3 Voice Alteration, CTCAE

description: Severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology


description: An epithelioid hemangioendothelioma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 2 Vision Decreased, CTCAE

description: Moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


name: Grade 2 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Juvenile Myelomonocytic Leukemia-Like Neoplasm

description: A myeloid neoplasm that resembles juvenile myelomonocytic leukemia by clinical and hematologic criteria but lacks mutations of the RAS pathway. Secondary mutations may be present.


Grade 4 Ovarian Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 4 Intraoperative Hemorrhage, CTCAE


Liver Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is 2-20 per 10 HPF.


name: Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Spinal Fracture, CTCAE

description: Mild back pain; nonprescription analgesics indicated


name: Grade 3 Nose Intra-Operative Injury, CTCAE


name: Invasive Poorly Differentiated Urothelial Carcinoma

description: Invasive urothelial carcinoma that lacks the morphological features indicating urothelial origin. Immunohistochemical studies are required to demonstrate the urothelial lineage in these tumors.


name: Grade 5 Trachea Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Diffuse malignant lymphoma - large cleaved cell

description: Antiquated term describing non-Hodgkin lymphomas that are usually diffuse and are composed of large cells with irregular nuclei, invisible nucleoli and a small amount of cytoplasm.  This morphologic category includes both mature B- and mature T-cell lymphomas.


name: Grade 5 Lower Gastrointestinal Hemorrhage NOS, CTCAE


Stage I Bladder Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Pseudomonas-Related Vasculitis

description: A necrotizing vasculitis caused by Pseudomonas aeruginosa.


Grade 2 Chronic Kidney Disease, CTCAE

description: eGFR or CrCl 59-30 ml/min/1.73 m2


Vaginal adenocarcinoma metastatic

description: An adenocarcinoma that arises from the vagina and has metastasized to other anatomic sites.


Skin Papilloma, CTCAE

description: A disorder characterized by the presence of one or more warts.


name: Grade 3 Upper Airway NOS Intra-Operative Injury, CTCAE


name: Grade 5 Peripheral Nerve Infection, CTCAE

description: Death


Physical addiction

description: The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered.


Grade 3 Feeding Intolerance, AE

description: An adverse event in a newborn characterized by severe feeding intolerance; requiring major changes in feeding support indicated (e.g. change to total parenteral nutrition (TPN) or gavage).


name: Stage III Cervical Cancer AJCC v6 and v7

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T1, N1, M0), (T2, N1, M0), (T3a, N1, M0), (T3b, Any N, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non functioning kidney.  N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Grade 3 Enterocolitis, CTCAE

description: Severe or persistent abdominal pain; fever; ileus; peritoneal signs


name: Mixed Phenotype Acute Leukemia, Rare Types

description: A very rare mixed phenotype acute leukemia in which the blasts express combinations of B, T, myeloid, and megakaryocytic lineage markers but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation. The prognosis is usually unfavorable.


description: A lymphoproliferative disorder caused by the human herpesvirus 8 (HHV8). This category includes the following: HHV8-positive multicentric Castleman disease; HHV8-positive diffuse large B-cell lymphoma, not otherwise specified; primary effusion lymphoma; and germinotropic lymphoproliferative disorders.


name: Grade 2 Cranial Nerve VIII Neuropathy, CTCAE


name: Grade 3 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Small Intestine Infection, CTCAE

description: Death


name: Unresectable Ureter Urothelial Carcinoma

description: Ureter urothelial carcinoma that is not amenable to surgical resection.


Grade 5 Hypopituitarism, CTCAE

description: Death


name: Grade 2 Paroxysmal Atrial Tachycardia, CTCAE

description: Non-urgent medical intervention indicated


Abnormal Vital Capacity

description: A pulmonary function test result indicating an abnormal vital capacity as compared to the predicted value.


Grade 1 Hiccups, CTCAE

description: Mild symptoms; intervention not indicated


Grade 1 Dysesthesia, CTCAE

description: Mild sensory alteration


Fredrickson Type III lipidaemia

description: A laboratory test result indicating an inheritable form of dysbetalipoproteinemia, in which there are excess intermediate-density lipoproteins in the blood.


Grade 1 Hypocalcemia, CTCAE

description: Corrected serum calcium of <LLN-8.0 mg/dL; <LLN-2.0 mmol/L; Ionized calcium <LLN-1.0 mmol/L


name: Grade 2 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


Grade 5 Periorbital Infection, CTCAE

description: Death


description: A subtype of myelodysplastic syndrome which initially lacks findings appropriate for classification into any other myelodysplastic category.  There are no specific morphologic findings.  The diagnosis can be made in the following instances: 1. in cases of refractory cytopenia with unilineage dysplasia or refractory cytopenia with multilineage dysplasia but with 1% blasts in the peripheral blood; 2: in cases of myelodysplastic syndrome with unilineage dysplasia which are associated with pancytopenia; 3: in cases with persistent cytopenia (s) with 1% or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10% of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome. (WHO, 2008)


Grade 2 Pancreatic Duct Stenosis, CTCAE

description: Symptomatic; altered GI function


Stage IVA Prostate Cancer AJCC v8

description: Stage IVA includes: Any T, N1, M0, PSA: Any, Grade Group: Any. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. (AJCC 8th ed.)


name: Stage 0 Digestive System Neuroendocrine Tumor AJCC v7

description: Stage 0 includes: Tis, N0, M0.  Tis (applies only to stomach): Carcinoma in situ/dysplasia (tumor size less than 0.5 mm), confined to mucosa. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Juvenile Dermatomyositis Sine Myositis

description: A rare form of juvenile dermatomyositis that manifests with characteristic cutaneous findings for at least six months in the absence of any detectable muscle involvement.


Advanced Cutaneous Melanoma

description: Cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Non-Metastatic Mass

description: A benign or malignant solid pathologic process that has not spread from its site of origin to another anatomic site.


Grade 3 Enterovesical Fistula, CTCAE

description: Invasive intervention indicated


name: Grade 3 Teeth Intra-Operative Injury, CTCAE


name: Grade 1 Blood Antidiuretic Hormone Abnormal, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Hallucinogen dependence, episodic

description: Physical and psychological dependence on hallucinogenics, which is associated with a pattern of episodic use.


name: Stage IIA Ampulla of Vater Cancer AJCC v7

description: Stage IIA includes: T3, N0, M0.  T3: Tumor invades the pancreas.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 4 Anal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 5 Budd-Chiari Syndrome, CTCAE

description: Death


name: Grade 1 Radiation Recall Reaction (Dermatologic), CTCAE

description: Faint erythema or dry desquamation


name: Grade 3 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Refractory Myelofibrosis

description: Myelofibrosis that is resistant to treatment.


Grade 5 Somnolence, CTCAE

description: Death


name: Grade 2 Pancreas or Pancreatic Duct Stricture or Stenosis, CTCAE


Fetal Growth Retardation, CTCAE

description: A disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight.


name: Childhood Acute Lymphoblastic Leukemia Toronto Guidelines v2, Tier 1

description: A term that refers to the staging of childhood acute lymphoblastic leukemia according to the tier 1 Toronto childhood cancer staging guidelines v2.


Metastatic Fallopian Tube Carcinoma

description: A carcinoma that arises from the fallopian tube and has metastasized to another anatomic site.


Appendix Perforation, CTCAE

description: Appendix Perforation that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Grade 5 Disease Progression, CTCAE

description: Death


name: Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


Proliferative Actinic Keratosis

description: Actinic keratosis characterized by the presence of dermal projections of nested atypical keratinocytes and dense dermal inflammation.


name: Monoclonal Gammopathy of Renal Significance

description: A condition caused by a B-cell or plasma cell clone resulting in the deposition of the secreted monoclonal immunoglobulin, without evidence for overt lymphoma or myeloma. This category includes a wide spectrum of renal pathology and include such lesions as immunoglobulin-associated amyloidosis, the monoclonal immunoglobulin deposition diseases (MIDDs; light chain deposition disease, heavy chain deposition disease, and light and heavy chain deposition disease), proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID), C3 glomerulopathy with monoclonal gammopathy, light chain proximal tubulopathy (Fanconi syndrome), and several others.


Grade 1 Anosmia, CTCAE

description: Present


name: Unresectable Malignant Digestive System Neoplasm

description: A malignant digestive system neoplasm that is not amenable to surgical resection.


No Radiating Chest Pain

description: An indication that the chest pain dose not radiate.


name: Cranial Nerve VI Intra-Operative Injury, CTCAE


Grade 2 Mitral Valve Disease, CTCAE

description: Asymptomatic; moderate regurgitation or stenosis by imaging


Grade 5 Salivary Gland Fistula, CTCAE

description: Death


Grade 5 Infective Myositis, CTCAE

description: Death


name: Grade 2 Lower Extremity Soft Tissue Necrosis, CTCAE


name: Grade 2 Intraoperative Gastrointestinal Injury, CTCAE

description: Partial resection of injured organ/structure indicated


name: Outer Ear Pinna Intra-Operative Injury, CTCAE


name: Grade 1 Cranial Nerve X Intra-Operative Injury, CTCAE


name: Melanoma in Chronically Sun-Exposed Skin

description: A melanoma that arises from a chronically sun-exposed skin area. It is associated with severe actinic keratosis.


name: Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Pancreatic Duct Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 5 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Anxiety, CTCAE

description: Severe symptoms; limiting self care ADL; hospitalization indicated


Stage III Esophageal Cancer

description: Stage III includes: T3, N1, M0 and T4, Any N, M0) T3: Tumor invades adventitia. T4: Tumor invades adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) -2003


name: Stage IV Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (AJCC 7th ed.)


Scrotal Cyst

description: A cystic lesion located in the scrotum.


name: International Normalized Ratio of Prothrombin Time Level Finding

description: A finding that indicates the international normalized ratio of prothrombin time level in a sample.


name: Stage I Digestive System Neuroendocrine Tumor AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Stomach: tumor invades lamina propria or submucosa and is 1 cm or less in size; duodenum /jejunum/ileum: tumor invades lamina propria or submucosa and is 1 cm or less in size; ampulla: tumor 1 cm or less; colon or rectum: tumor invades lamina propria or submucosa and is 2 cm or less.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Grade 5 Scrotum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Spleen Intra-Operative Injury, CTCAE


Colonic Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the colon.


Grade 5 Esophageal Perforation, CTCAE

description: Death


Neonatal encephalopathy

description: Abnormal functioning of the central nervous system in the newborn period that may be due to a variety of etiologies including hypoxia/ischemia, metabolic disturbance, or infection.


Grade 1 Rash Acneiform, CTCAE

description: Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness


name: Grade 4 Forced Expiratory Volume Decreased, CTCAE


Pre-Pre-B Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia of early B-lineage.


name: Grade 5 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Advanced Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Common blue nevus of skin

description: A blue nevus that is not associated with increased cellularity.


name: Grade 2 Fallopian Tube Stricture or Stenosis, CTCAE


name: Grade 2 Injury To Inferior Vena Cava, CTCAE

description: Symptomatic; repair or revision not indicated


Metastatic Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that has spread to another anatomical site.


Grade 4 Myocardial Infarction, CTCAE

description: Life-threatening consequences; hemodynamically unstable


name: Metastatic Malignant Peripheral Nerve Sheath Tumor

description: The presence of malignant Schwann cell growth (benign variant is known as neurofibroma) at a site removed from the primary site of tumor growth.


undifferentiated carcinoma of cervix

description: A rare carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation.


name: Simple dislocation, multiple and ill-defined sites

description: Multiple bone displacements without clear distinction that are not associated with an external wound.


Ovarian Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the ovary.


name: Refractory Non-Muscle Invasive Bladder Urothelial Carcinoma

description: Non-muscle invasive bladder urothelial carcinoma that is resistant to treatment.


Grade 2 Bruising, CTCAE

description: Generalized


name: Adult Mixed Cellularity Classical Hodgkin Lymphoma

description: Mixed cellularity classic Hodgkin lymphoma occurring in adults.


Prostate Neuroendocrine Tumor

description: An extremely rare, slow-growing well-differentiated neuroendocrine neoplasm that affects the prostate gland.


name: Acute Myelomonocytic Leukemia without Abnormal Eosinophils

description: Acute myelomonocytic leukemia without an abnormal eosinophilic component in the bone marrow.


Acquired Factor XII Deficiency

description: An acquired coagulation disorder characterized by the partial or complete absence of factor XII activity in the blood.


name: Diffuse Laminar Endocervical Hyperplasia

description: A benign band-like proliferation of tightly-packed, small to medium sized endocervical glands below the surface of the endocervical canal.


name: Grade 4 Colon Intra-Operative Injury, CTCAE


Grade 3 Tracheal Obstruction, CTCAE

description: Stridor or respiratory distress limiting self care ADL; invasive intervention indicated (e.g., stent, laser)


name: Grade 1 Cranial Nerve V Neuropathy, CTCAE


Mesenteric abscess

description: An abscess that is located in any part of the tissue composing the mesentery, and that generally arises from an infection in an adjacent area of the intestine.


name: Acute Myeloid Leukemia with U2AF1 Mutation

description: An acute myeloid leukemia associated with U2AF1 gene mutation.


Subungual Melanoma

description: A melanoma that arises from the area underneath a fingernail or toenail. It affects the fingernails more often than the toenails.


Accident involving aircraft, NOS

description: An accident taking place aboard, or involving, any type of aircraft.


name: Grade 2 Infections and Infestations - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Erythema Multiforme, CTCAE

description: A disorder characterized by target lesions (a pink-red ring around a pale center).


Refractory Erdheim-Chester Disease

description: Erdheim-Chester disease that does not respond to treatment.


Stage IV Cervical Cancer AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Grade 3 Alkalosis, CTCAE

description: pH >7.5


Stage IIIB Vulvar Cancer AJCC v8

description: Stage IIIB includes: T1-T2, N2a, N2b, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


name: Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Neonatal Diarrhea, AE

description: An adverse event in a newborn characterized by an increase of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline.


Grade 3 Edema Face, CTCAE

description: Severe swelling; limiting self care ADL


Grade 1 Stomal Ulcer, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Benzene-Related Acute Myeloid Leukemia

description: Acute myeloid leukemia caused by benzene.


Decreased CYBA Expression

description: An indication that the expression of CYBA is lower than the normal range of values.


Stage IV Gastric Cancer with Metastasis

description: T4,N2,MO (from PDQ)


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 6

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the PARN gene, encoding poly(A)-specific ribonuclease PARN.


Grade 1 Nail Changes, CTCAE

description: Present


Grade 3 Conjunctivitis Infective, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 2 Face NOS Intra-Operative Injury, CTCAE


name: Acute on chronic diastolic heart failure

description: Acute decompensation of chronic diastolic congestive heart failure.


Benign Paratesticular Neoplasm

description: A neoplasm that arises from the paratesticular structures and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Penile Infection

description: An infectious process affecting the penis.


Grade 2 Scrotal Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Oral Multifocal Epithelial Hyperplasia

description: Benign multifocal squamous epithelial proliferation affecting the oral mucosa. It is associated with human papilloma virus infection.


Syringomyelia and Hydromyelia

description: Syringomyelia associated with accumulation of cerebrospinal fluid in the spinal cord.


name: Grade 2 Superior Vena Cava Intra-Operative Injury, CTCAE


name: Grade 3 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Burn, CTCAE

description: Life-threatening consequences


name: Non-Infectious Wound Complication, CTCAE


Grade 4 Laryngeal Stenosis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Palsy of vagus nerve

description: Partial or complete paralysis of the vagus nerve.


name: Grade 3 Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Facial Nerve Palsy Related to Birth

description: A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve sustained during the birthing process.


Grade 5 Pericarditis, CTCAE

description: Death


Grade 3 Myasthenia Gravis, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Renal Colic, CTCAE

description: A disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of crystals/kidney stones.


name: Grade 2 Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: FIGO Stage IIIC Gestational Trophoblastic Tumor


Grade 1 Optic Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only


name: Squamous cell carcinoma, clear cell type

description: A squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm.


name: Transitional cell cancer of renal pelvis and ureter metastatic

description: A urothelial carcinoma of the renal pelvis and ureter that has spread from its original site of growth to another anatomic site.


name: Grade 1 Intraoperative Urinary Injury, CTCAE

description: Primary repair of injured organ/structure indicated


Broad Ligament Ependymoma

description: A rare neoplasm that arises from the broad ligament and shows ependymal differentiation.


Appendix Serrated Lesions and Polyps

description: Polyps that arises from the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


name: Grade 5 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Recurrent Neuroendocrine Carcinoma

description: The reemergence of neuroendocrine carcinoma after a period of remission.


COVID-19-Associated Ataxia

description: Ataxia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Grade 2 Cranial Nerve I Neuropathy, CTCAE


Spitz Tumor

description: A term that refers to a group of melanocytic neoplasms that are composed of epithelioid and/or spindle cells and extend from the epidermis into the reticular dermis, often in a wedge-shaped configuration. They are usually associated with oncogenic mutations that activate the MAP-kinase pathway. This category includes Spitz nevus, Spitz melanocytoma, and Spitz melanoma.


Childhood Granular Cell Tumor

description: A granular cell tumor that occurs during childhood.


Thrush, CTCAE

description: A disorder characterized by a suspected candidal infection involving an oral mucosal surface.


Atypical meningioma

description: A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis.


Grade 1 Hyperlipidemia, CTCAE

description: Requiring diet changes


Stage IVA Osteosarcoma AJCC v7

description: Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


name: Grade 4 Bronchus Intra-Operative Injury, CTCAE


PSA Failure

description: An increase in serum prostate-specific antigen (PSA) levels following treatment for prostate cancer.


Grade 2 Watering Eyes, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


name: Blood Lactate Dehydrogenase Increased, CTCAE

description: A finding based on laboratory test results that indicate increased levels of lactate dehydrogenase in the blood specimen.


Resectable Astrocytoma

description: An astrocytoma that is amenable to surgical resection.


Grade 3 Pericardial Effusion, CTCAE

description: Effusion with physiologic consequences


name: Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm

description: An acute myeloid leukemia developing in patients with a prior history of myeloproliferative neoplasm.


name: Grade 1 Neonatal Respiratory Distress Syndrome, AE

description: An adverse event in a newborn characterized by radiological evidence without clinical signs; clinical evidence of mildly increased respiratory distress (e.g. increased work of breathing) without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); no supportive care required.


Grade 3 Sinus Disorder, CTCAE

description: Stenosis with significant nasal obstruction; limiting self care ADL


Grade 1 Adrenal Insufficiency, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 4 Oral Cavity Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Cardiac tuberculosis

description: Tuberculosis affecting the heart.


Grade 2 Vaginal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 2 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps) - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Sinus perforation

description: A rupture in the sinus tissue due to traumatic or pathologic processes.


Post-Mastectomy Pain Syndrome

description: Chronic pain following mastectomy or lumpectomy that usually affects the anterior thorax, axilla, and/or medial upper arm.


Grade 4 Laryngospasm, CTCAE

description: Persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection)


Radiation Damage

description: Injury resulting from exposure to ionizing radiation.


name: Grade 4 Salivary Gland or Saliva Changes, CTCAE


name: Myxoid Glioneuronal Tumor of the Septum Pellucidum

description: A myxoid glioneuronal tumor that arises from the septum pellucidum.


name: Grade 1 Rectum Stricture or Stenosis, CTCAE


Refractory Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that does not respond to treatment.


name: Grade 4 Pulmonary Fibrosis Radiographic Changes, CTCAE


name: Grade 4 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


name: Grade 1 Other Pulmonary and Upper Respiratory, CTCAE


name: Grade 2 Conjunctiva Infection with Unknown Absolute Neutrophil Count, CTCAE


Childhood Fibrous Dysplasia

description: Fibrous dysplasia that occurs during childhood.


Hypertrophic Actinic Keratosis

description: Actinic keratosis characterized by the presence of epidermal hyperplasia, parakeratosis, and orthokeratosis.


name: Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Bronchospasm, CTCAE

description: Death


name: Refractory Anaplastic Pleomorphic Xanthoastrocytoma

description: Anaplastic pleomorphic xanthoastrocytoma that is resistant to treatment.


name: Idiopathic Cytopenias of Undetermined Significance

description: Cytopenia in one or more hematopoietic cell lineages that remains unexplained following thorough evaluation. The hematopoietic cell dysplasia is mild and does not fulfill the criteria for myelodysplastic syndrome, but the cytopenia may be severe. There is no evidence of clonal hematopoiesis or the variant allele frequency (VAF) is less that 2 percent. There is no other evidence of hematologic malignancy. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


name: Hodgkin's disease mixed cellularity stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Grade 3 Nose Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Hyponatremia, CTCAE

description: 125-129 mmol/L symptomatic; 120-124 mmol/L regardless of symptoms


Grade 3 Laryngeal Obstruction, CTCAE

description: Limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)


Grade 3 Dysphasia, CTCAE

description: Severe receptive or expressive characteristics; impairing ability to read, write or communicate intelligibly


Grade 2 Dysarthria, CTCAE

description: Moderate impairment of articulation or slurred speech


name: Recurrent Appendix Mucinous Adenocarcinoma

description: The reemergence of appendix mucinous adenocarcinoma after a period of remission.


Lipoprotein(a) Quantitative Trait Locus

description: A metabolic disorder caused by polymorphisms in the LPA gene that affect the number of kringle-4 repeats in the encoded protein, apolipoprotein(a) (apo(a)). The number of kringle-4 repeats are inversely correlated with apo(a) expression in the blood. Thus, forms of apo(a) with fewer repeats are expressed at elevated levels, which leads to increased concentrations of apo(a)-containing lipoprotein particles and an elevated risk for atherosclerosis, cardiovascular disease, and coronary artery disease.


name: Grade 5 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Benign squamous cell tumor

description: A non-metastasizing neoplasm composed of squamous cells. The neoplastic cells do not display malignant features.


Surface Osteoma

description: An osteoma that arises from the surface of the bone.


Endometriosis of thorax

description: A condition characterized by the presence of functioning endometrial tissue in the lung, pleura, chest wall, and/or diaphragm.


Micronodular adrenal hyperplasia

description: Adrenal hyperfunction associated with multiple bilateral adrenal nodules, usually less than one centimeter in diameter.


name: Grade 5 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Hypoparathyroidism, CTCAE

description: Death


name: Stage I Acral Lentiginous Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 5 Hepatic Failure, CTCAE

description: Death


name: Intestinal Metaplasia of Bladder Urothelium


Resectable Malignant Mesothelioma

description: Malignant mesothelioma that is amenable to surgical resection.


Grade 1 Flashing Lights, CTCAE

description: Symptomatic but not limiting ADL


name: Fistula of intestine, excluding rectum and anus

description: An abnormal connection between the intestine and another epithelial-lined structure, but that does not include the rectum or anus.


name: Grade 1 Trachea Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Pancreatic Undifferentiated Carcinoma with Rhabdoid Cells

description: An undifferentiated carcinoma that arises from the pancreas. It is characterized by the presence of rhabdoid cells.


name: Stage III Appendix Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 2 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


name: Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q

description: A rare acute myeloid leukemia that occurs in childhood and is characterized primarily by deletions of 5q.


Grade 3 Abducens Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


Grade 4 Rectal Obstruction, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Locally Advanced Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Adverse Event Associated with the Gastrointestinal System


name: Grade 1 Lower Extremity Vein Intra-Operative Injury, CTCAE


endometritis following abortion

description: Endometritis that develops following an abortion.


name: Grade 4 Herpes Simplex Reactivation, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Conjunctival Reactive Lymphoid Hyperplasia

description: A polyclonal proliferation of lymphoid tissue in the conjunctiva that typically occurs in young adults. It usually presents as a unilateral, red or orange, painless swelling and is probably caused by chronic antigen stimulation. (WHO 2018)


Supratentorial Glioblastoma

description: A glioblastoma that occurs in the supratentorial region.


Ostomy Site Pain

description: Pain at the site of an ostomy.


name: Grade 3 Upper Extremity Artery Injury, CTCAE


Metastatic Malignant Germ Cell Tumor

description: A malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


Benign vascular neoplasm

description: A mesenchymal neoplasm that arises from vascular tissue usually of the skin. It is characterized by the presence of vascular channel formation and endothelial cells. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases.


name: Refractory Mixed Phenotype Acute Leukemia

description: Mixed phenotype acute leukemia that does not respond to treatment.


Gastric Perforation, CTCAE

description: A disorder characterized by a rupture in the stomach wall.


REVESZ SYNDROME (disorder)

description: An autosomal dominant form of dyskeratosis congenita, caused by mutation(s) in the TINF2 gene, encoding TERF1-interacting nuclear factor 2. It is a fatal disease associated with exudative retinopathy and bone marrow failure.


name: Grade 2 Colon Stricture or Stenosis, CTCAE


name: Grade 4 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Anaemias due to disorders of glutathione metabolism

description: Anemia resulting from an abnormality of glutathione deficiency.


Stage IIB Merkel Cell Carcinoma AJCC v7

description: Stage IIB includes: T2/T3, cN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Grade 1 Testicular Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 1 Inferior Vena Cava Intra-Operative Injury, CTCAE


Pelvic Cancer

description: A primary or metastatic malignant neoplasm that affects the organs and structures of the pelvis.


name: Grade 2 Cecum Intra-Operative Injury, CTCAE


name: Adult TdT Positive Acute Lymphoblastic Leukemia

description: TdT positive acute lymphoblastic leukemia that occurs during adulthood.


Grade 2 Gallbladder Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 2 Leukoencephalopathy, CTCAE

description: Moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly


name: Other Associated with the Heart in General, CTCAE


name: Grade 5 Neonatal Coagulation Disorder, AE

description: A coagulation disorder adverse event in a newborn which results in death.


name: Grade 2 Cecum or Appendix Hemorrhage, CTCAE


KATP-Associated Hyperinsulinism

description: Hyperinsulinism caused by non-functional beta-cell ATP-sensitive potassium channels due to inactivating mutation(s) in either the ABCC8 or KCNJ11 gene.


Third Ventricle Germinoma

description: A germinoma that arises from the third ventricle.


name: Grade 1 Atrioventricular Block First Degree, CTCAE

description: Asymptomatic, intervention not indicated


name: Grade 3 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Pulmonary Fibrosis, CTCAE

description: A disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure.


name: Stage IIA Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Grade 2 Phlebitis Including Superficial Thrombosis, CTCAE


Grade 1 Concentration Impairment, CTCAE

description: Mild inattention or decreased level of concentration


name: Radiating Chest Pain Along Anterior Axillary Line

description: The location of the radiating chest pain is along an imaginary vertical line that descends along the lateral aspect of the chest wall originating from the armpit.


Grade 4 Small Intestine Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 5 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Liposarcoma recurrent

description: The reemergence of liposarcoma after a period of remission.


Neoplasm of Uncertain Histogenesis

description: A benign or malignant, primary or metastatic neoplasm with uncertain histogenesis.


name: Merkel Cell Polyoma Virus-Negative Merkel Cell Carcinoma

description: A Merkel cell carcinoma that is not associated with Merkel cell polyoma virus infection.


Metaplastic Synovial Cyst

description: A cyst lined by tissue that resembles synovial villi.


Grade 1 Hypopituitarism, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Grade 1 Lower Extremity Artery Injury, CTCAE


name: Refractory Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that is resistant to treatment.


Paratesticular Squamous Cell Carcinoma

description: An extremely rare squamous cell carcinoma that arises from the paratesticular structures.


name: Grade 4 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


Recurrent Myeloid Sarcoma

description: The reemergence of myeloid sarcoma after a period of remission.


Assault

description: A physical attack.


name: Diffuse Glioneuronal Tumor with Oligodendroglioma-Like Features and Nuclear Clusters

description: A provisional tumor entity described in the supratentorial brain and characterized by a distinct DNA methylation profile and monosomy of chromosome 14. It is composed of small to medium-sized cells showing perinuclear oligodendroglioma-like haloes, scattered multinucleated cells, and nuclear clusters composed of large pleomorphic nuclei. Most cases have been reported in pediatric patients.


name: Grade 3 Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Vaccination Complication, CTCAE

description: A disorder that occurs after the injection of a substance with antigenic properties, administered to activate the immune system.


name: Treatment related acute myeloid leukaemia

description: An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation.  (WHO, 2001)


name: Grade 2 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Bladder Stricture or Stenosis, CTCAE


Grade 1 Gastritis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Transitional cell carcinoma in situ

description: A lesion in which the surface epithelium of the bladder or the renal pelvis and ureter contains transitional cells which display malignant cytologic characteristics.  There is no evidence of stromal invasion.


name: Grade 3 Upper Airway Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Ann Arbor Stage IV AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Grade 1 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


Ureteric Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures).


name: Stage III Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading the visceral peritoneum (serosa) or other organs. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Myasthenia Gravis, CTCAE

description: A disorder characterized by weakness and rapid fatigue of any of the skeletal muscles.


Tracheal Mucositis, CTCAE

description: A disorder characterized by an inflammation or ulceration involving the mucous membrane of the trachea.


Psychosis, CTCAE

description: A disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor.


Grade 1 Creatinine Increased, CTCAE

description: >ULN-1.5 x ULN


name: Aggressive Systemic Mastocytosis with an Associated Germ Cell Tumor

description: Aggressive systemic mastocytosis associated with a germ cell tumor.


name: Grade 4 Stenosis of Gastrointestinal Stoma, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 2 Tinnitus, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Grade 5 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IIIC Appendix Carcinoma AJCC v7

description: Stage IIIC includes: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Gallbladder Cancer AJCC v6

description: Stage III includes: (T4, Any N, M0).  T4: Tumor invades main portal vein or hepatic artery or invades multiple extrahepatic organs or structures. (AJCC 6th ed.)


name: Grade 5 Spermatic Cord Anastomotic Leak, CTCAE

description: Death


name: Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIB includes: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Bartholin Gland Hyperplasia

description: Nodular/lobular proliferation of normal Bartholin gland tissue and ducts.


Acquired arteriovenous aneurysm

description: An arteriovenous fistula, the cause of which is not present at birth.


name: Grade 3 Blood Corticotrophin Decreased, CTCAE

description: Hospitalization indicated


Grade 4 Anemia, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Retinopathy, CTCAE

description: Asymptomatic; clinical or diagnostic observations only


Grade 5 Encephalopathy, CTCAE

description: Death


name: Grade 4 Peripheral Motor Nerve NOS Intra-Operative Injury, CTCAE


Refractory Biliary Tract Carcinoma

description: Biliary tract carcinoma that is resistant to treatment.


Bigeminy, CTCAE

description: Premature heartbeats alternating regularly with normal beats. It can be associated with hypoxia, ischemia, acute myocardial infarction, and medication overdose.


Primary Raynaud Phenomenon

description: Raynaud phenomenon without a known underlying autoimmune disorder.


Gallbladder Mucinous Cystic Neoplasm

description: An epithelial, usually multiloculated neoplasm arising from the gallbladder. It occurs predominantly in females. Signs and symptoms include abdominal mass, abdominal pain, and jaundice. Morphologically, the cystic spaces are lined by columnar epithelium and contain mucinous or serous fluid.


Advanced Melanoma

description: Melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Grade 3 Gallbladder Obstruction, CTCAE

description: Symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated


name: Grade 4 Biliary Tree Left Hepatic Duct Intra-Operative Injury, CTCAE


name: Skin and Subcutaneous Tissue Disorders - Other, Specify, CTCAE


name: Grade 1 Vein NOS Intra-Operative Injury, CTCAE


name: Prostate Adenocarcinoma without Neuroendocrine Differentiation

description: A prostate adenocarcinoma characterized by the absence of focal or diffuse neuroendocrine differentiation.


name: Metastatic Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread to other anatomic sites.


Grade 1 Uterine Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Grade 4 Female Genital Tract Fistula, CTCAE


name: Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Hypoglycemia, CTCAE

description: Death


Adenocarcinoma, Oxyphilic

description: An adenocarcinoma characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast carcinoma, and salivary gland oncocytic carcinoma.


Non-Neoplastic Uveal Disorder

description: A non-neoplastic disorder that affects the uvea.


name: Hodgkin's disease mixed cellularity recurrent

description: The reemergence of mixed cellularity classic Hodgkin lymphoma after a period of remission.


name: Grade 2 Abdomen Soft Tissue Necrosis, CTCAE


Pancreatic Acinar Cell Neoplasm

description: An epithelial neoplasm that arises from the exocrine pancreas.  It is characterized by the presence of neoplastic cells that resemble acinar cells and produce pancreatic exocrine enzymes.  The vast majority are carcinomas.


name: Grade 3 Brachial Plexus Intra-Operative Injury, CTCAE


Grade 2 Colonic Ulcer, CTCAE

description: Symptomatic; altered GI function


Phantom pain

description: Painful sensation related to a limb or an organ that is removed from or is not physically part of the body.


name: Metastatic Bladder Giant Cell Urothelial Carcinoma

description: Bladder giant cell urothelial carcinoma that has spread to another anatomic site.


Uveal prolapse

description: The protrusion of uveal tissue through an opening in the sclera.


Unresectable Melanoma

description: Melanoma which is not amenable to surgical resection.


name: Grade 1 Cranial Nerve IV Neuropathy, CTCAE


Alcohol-Related Carcinoma

description: A carcinoma that is caused by alcohol abuse.


name: Retinoblastoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


name: Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chronic pulmonary embolism

description: Persistent and long-standing pulmonary embolism.


Visceral edema

description: Accumulation of an excessive amount of watery fluid in the visceral tissues. Symptoms include abdominal pain, nausea, vomiting, and diarrhea.


name: Intermediate Grade B-Cell Non-Hodgkin's Lymphoma


Liver Non-Epithelial Neoplasm

description: A benign or malignant non-epithelial neoplasm that affects the liver.


name: Grade 1 Vaginal Stenosis and Length, CTCAE


name: undifferentiated carcinoma of anal canal

description: A usually aggressive malignant epithelial neoplasm that arises from the anal canal.  It is composed of malignant cells which do not display evidence of glandular or squamous differentiation.


Grade 4 Radiculitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 4 Peripheral Ischemia, CTCAE

description: Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


Hematuria, CTCAE

description: A disorder characterized by laboratory test results that indicate blood in the urine.


Female Reproductive System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the female reproductive system. Representative examples include ovarian carcinoma, cervical carcinoma, and endometrial carcinoma.


Grade 2 Kidney Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Bile Duct Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of moderate atypia.


name: Invasive Bladder Poorly Differentiated Urothelial Carcinoma

description: Invasive bladder urothelial carcinoma that lacks the morphological features indicating urothelial origin. Immunohistochemical studies are required to demonstrate the urothelial lineage in these tumors.


Stage IIA Merkel Cell Carcinoma AJCC v7

description: Stage IIA includes: T2/T3, pN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  pN0: No regional lymph node metastasis by pathologic examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


name: Pathologic Stage IA Cutaneous Melanoma AJCC v8

description: Stage IA includes: (T1a, N0, M0); (T1b, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Grade 5 Lymphatic Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

description: Average QTc 450-480 ms


name: Grade 4 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Stage IIB Gallbladder Cancer AJCC v8

description: Stage IIB includes: T2b, N0, M0. T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Gastrointestinal Disorders - Other, Specify, CTCAE


name: Metastatic Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: Clear cell (glycogen-rich) urothelial carcinoma that has spread to another anatomic site.


name: Recurrent Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: The reemergence of accelerated phase chronic myeloid leukemia, BCR-ABL1 positive after a period of remission.


Neonatal infectious disorder

description: An infectious disorder that occurs during the neonatal period. Representative examples include streptococcal infection, E.coli infection, and bacterial meningitis.


Grade 4 Hypophosphatemia, CTCAE

description: Life-threatening consequences


Resectable Glioblastoma

description: A glioblastoma that is amenable to surgical resection.


name: Grade 3 Sinus Intra-Operative Injury, CTCAE


Grade 2 Ataxia, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: New Onset Atrial Flutter Related to COVID-19

description: Newly occurring atrial flutter in a patient with probable or confirmed acute COVID-19.


Locally Advanced Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Endometrial Mucinous Adenocarcinoma, Intestinal-Type

description: A rare mucinous adenocarcinoma arising from intestinal metaplasia of the endometrium.


Blood Cardiac Troponin T Increased

description: A laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen.


Dog Bite

description: A wound received from the teeth of a dog.


Grade 4 Colitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Colon Intra-Operative Injury, CTCAE


name: Stage I Centroblastic Follicular Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Intraoperative Neurological Injury, CTCAE

description: A finding of damage to the nervous system during a surgical procedure.


name: Female Reproductive System Precancerous Condition

description: A precancerous lesion that arises from the female reproductive system. Representative examples include atypical endometrial hyperplasia, endometrial intraepithelial neoplasia, and cervical intraepithelial neoplasia.


name: Grade 3 Blood and Lymphatic System Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Primary Bone Hodgkin Lymphoma

description: An exceedingly rare Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.


name: Grade 3 Peristomal Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Hearing Patients without Baseline Audiogram and Not Enrolled in a Monitoring Program, CTCAE


Lip Pain

description: Painful sensation in the lip.


Glaucoma, CTCAE

description: A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow.


Arthritis NOS aggravated

description: Exacerbation of an arthritic condition.


name: Localized Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has not spread to other anatomic sites.


Grade 2 Purpura, CTCAE

description: Combined area of lesions covering 10-30% BSA; bleeding with trauma


Fusion-Positive Rhabdomyosarcoma

description: A rhabdomyosarcoma characterized by the presence of chromosomal translocation t(1;13)(p36;q14) that results in PAX7-FOXO1 gene fusion; or translocation t(2;13)(q35;q14) that results in PAX3-FOXO1 gene fusion.


Adult Anaplastic Astrocytoma

description: An astrocytoma occurring in adults that is characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


name: Developmental and Epileptic Encephalopathy 85 with or without Midline Brain Defects

description: An X-linked dominant subtype of developmental and epileptic encephalopathy caused by mutation(s) in the SMC1A gene,  encoding structural maintenance of chromosomes protein 1A.


name: Locally Advanced Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has spread to nearby tissues or lymph nodes.


Factor XI Inactivation

description: Presence of inactivating antibodies to factor XI in the blood.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol. It is based on findings at surgery for patients who have received chemotherapy prior to surgery. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 2 Anxiety, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 5 Hypoalbuminemia, CTCAE

description: Death


name: Grade 1 Duodenum Intra-Operative Injury, CTCAE


Extrahepatic Bile Duct Carcinoid Tumor

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the extrahepatic bile ducts. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Vaginal Cancer by AJCC v7 Stage

description: A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 7th edition.


Pure Erythroid Leukemia

description: Acute erythroid leukemia characterized by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present.


Paratesticular Mucinous Cystadenoma

description: A rare mucinous cystadenoma that arises from the paratesticular structures.


name: Blood Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Benign neoplasm of liver

description: A neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 2 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Pancreas Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


H influenze type B Meningitis

description: Meningitis that is attributed to the bacteria H influenze type B.


name: Grade 1 Ovary Intra-Operative Injury, CTCAE


Urothelial carcinoma ureter recurrent

description: The reemergence of ureter urothelial carcinoma after a period of remission.


name: Grade 1 Thyroid Intra-Operative Injury, CTCAE


name: Grade 2 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


name: Grade 4 Neonatal Intraventricular Hemorrhage, AE

description: An adverse event in a newborn characterized by intraventricular hemorrhage with parenchymal venous infarction; resulting in life threatening consequences (e.g. refractory seizures, hypotension, respiratory depression); requiring urgent stabilization or surgical decompression.


name: Grade 2 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IA Testicular Cancer AJCC v8

description: Stage IA includes: pT1, N0, M0, S0. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


name: Grade 1 Liver Intra-Operative Injury, CTCAE


Stage II Cervical Cancer AJCC v8

description: Stage II includes: T2, Any N, M0. T2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina. M0: No distant metastasis. (AJCC 8th Ed.)


Rhinocephaly

description: A congenital anatomic defect characterised by the presence of a proboscis-like nose located above the eyes, which are partially or completely fused.


name: Grade 5 Bladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Upper Respiratory Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Stage IV Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


Condyloma acuminata of vulva

description: A benign human papillomavirus-related neoplasm that arises from the vulva. It is characterized by the presence of papillary structures with fibrovascular cores covered by stratified squamous epithelium showing koilocytotic changes.


Upper Aerodigestive Invasive Malignancy

description: A finding indicating the presence of an invasive upper aerodigestive tract malignancy.


name: Lugano Classification Stage IIE Adult Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: Grade 5 Thrombotic Microangiopathy, CTCAE


Premature Menopause, CTCAE

description: A disorder characterized by premature ovarian failure. Symptoms may include hot flashes, night sweats, mood swings, and a decrease in sex drive. Laboratory findings include elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH.)


Grade 3 Bone Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: High Grade Anal Intraepithelial Neoplasia

description: Anal canal or perianal skin intraepithelial neoplasia with moderate or severe dysplasia.


Stage 0 Merkel Cell Carcinoma AJCC v7

description: Stage 0 includes: Tis, N0, M0.  Tis: In situ primary tumor.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Childhood Lymphocyte-Rich Classic Hodgkin Lymphoma

description: Lymphocyte-rich classic Hodgkin lymphoma occurring in childhood.


Mandibular Buccal Bifurcation Cyst

description: An inflammatory collateral cyst that arises on the lower first or second molars. (WHO 2017)


Grade 3 Corneal Ulcer, CTCAE

description: Corneal ulcer without perforation in the affected eye


Grade 1 Cataract, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 4 Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Sleep Apnea, CTCAE

description: A disorder characterized by cessation of breathing for short periods during sleep.


name: Grade 5 Cranial Nerve II Neuropathy, CTCAE


Recurrent Biliary Tract Carcinoma

description: The reemergence of a carcinoma arising from any part of the biliary tract after a period of remission.


name: Gallbladder Flat Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia that affects the gallbladder epithelium.  It is characterized by the absence of intraluminal micropapillary projections.


Midgut Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the jejunum, ileum, proximal colon, or appendix.


name: Grade 2 Fibrosis-Deep Connective Tissue, CTCAE


Grade 2 Laryngeal Obstruction, CTCAE

description: Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Chronic Bullous Disease of Childhood

description: A blistering disorder characterized by linear deposition of IgA at the dermoepidermal junction.


Grade 2 Prolapse of Urostomy, CTCAE

description: Local care or maintenance; minor revision indicated


name: Myelodysplastic and myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis

description: A myelodysplastic/myeloproliferative neoplasm characterized by thrombocytosis, anemia, blasts less than 5% in bone marrow and less than 1% in peripheral blood, presence of SF3B1 gene mutation, absence of BCR/ABL fusion, absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions, and no history of other myelodysplastic/myeloproliferative neoplasms or myeloproliferative neoplasms and myelodysplastic syndromes.


name: Grade 5 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Vaginal Cancer by AJCC v6 Stage

description: A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 6th edition.


name: Cytogenetically Normal Acute Myeloid Leukemia Post Cytotoxic Therapy

description: Acute myeloid leukemia not associated with cytogenetic abnormalities and arising as a result of the mutagenic effect of chemotherapy and/or ionizing radiation.


Grade 4 Ileal Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Laryngeal Inflammation, CTCAE

description: A disorder characterized by an inflammation involving the larynx.


name: Grade 5 Persistent Pulmonary Hypertension of the Newborn, AE

description: A persistent pulmonary hypertension adverse event in a newborn which results in death.


name: Unresectable Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that is not amenable to surgical resection.


Childhood Grade II Meningioma

description: A grade II meningioma that occurs during childhood.


Periosteal Desmoid Tumor

description: A reactive, benign fibrous lesion that develops in the periosteum of the femur.  It usually affects boys and there is a history of trauma.  It is characterized by the formation of dense collagen tissue and reactive bone.


Stage IIB Testicular Cancer AJCC v8

description: Stage IIB includes: (Any pT/TX, N2, M0, S0); (Any pT/TX, N2, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Bacterial Zoonoses

description: A bacterial infection that is transmitted from animals to people.


name: Grade 3 Neck NOS Intra-Operative Injury, CTCAE


name: Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Lymph Leakage, CTCAE

description: A disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity.


name: Mucosal Melanoma of the Genitourinary System

description: A malignant melanocytic neoplasm that arises from a mucosal site of the genitourinary system.


name: Grade 5 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Biliary Tree Stricture or Stenosis, CTCAE


Bladder Spasm, CTCAE 5.0

description: A disorder characterized by a sudden and involuntary contraction of the bladder wall.


Grade 1 Dyspareunia, CTCAE

description: Mild discomfort or pain associated with vaginal penetration; discomfort relieved with use of vaginal lubricants or estrogen


name: Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

description: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome.


Refractory Malignant Mastocytosis

description: Malignant mastocytosis that is resistant to treatment.


Recurrent Ependymoma

description: The reemergence of ependymoma after a period of remission.


Malposition of Ureter

description: Orientation of a ureter in an unusual anatomic location.


name: Grade 1 Allergic Rhinitis Including Sneezing Nasal Stuffiness Postnasal Drip, CTCAE


name: Grade 4 Esophagus Intra-Operative Injury, CTCAE


name: Glioblastoma with Primitive Neuronal Component

description: A glioblastoma characterized by the presence of well-demarcated nodules which contain primitive cells exhibiting neuronal differentiation.


name: Grade 4 Toxic Epidermal Necrolysis, CTCAE

description: Skin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment)


Congenital Phrenic Nerve Palsy

description: Damage to the phrenic nerve that results in paralysis of the hemidiaphragm at birth.


Stage III Prostate Cancer AJCC v7

description: Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Small Cell Glioblastoma

description: A small cell glioblastoma that is resistant to treatment.


name: FIGO Stage IC Gestational Trophoblastic Tumor


Stage IA Cervical Cancer AJCC v8

description: Stage IA includes: T1a, Any N, M0. T1a: Tumor diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IVB Bladder Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1b. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


name: Musculoskeletal Chest Pain due to Slipping Rib Syndrome

description: A condition in which there is musculoskeletal chest pain associated with one or more ribs subluxing from the joint. (ACC/AHA)


Genetic anomaly of leukocyte

description: An abnormality of leukocytes, the cause of which is present from birth.


Weight Gain Due to Fluid Retention

description: A finding of rapid weight gain due to fluid retention.


Necrotizing granulomatous inflammation

description: A granuloma that contains areas of necrosis.  The majority of cases are of infectious origin.


Grade 3 Gastric Stenosis, CTCAE

description: Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated


Delirium, CTCAE

description: A disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition.


name: Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Partial Thromboplastin Time, CTCAE


Squamous cell papilloma of eyelid

description: A papilloma that arises from the eyelid. It is composed of squamous cells and is characterized by the presence of an acanthotic epithelium with hyperkeratosis and papillary projections with an inner fibrovascular core. It is the most common benign epithelial tumor of eyelid. It usually affects middle-aged or older adults.


name: Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Metabolic or Respiratory Acidosis, CTCAE


name: Forced Expiratory Volume Decreased, CTCAE

description: A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds.


Ureter Cancer by AJCC v8 Stage

description: A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. (from AJCC 8th Ed.)


Late-Onset Retinal Degeneration

description: An autosomal dominant condition caused by mutation in the C1QTNF5 gene, encoding complement C1q tumor necrosis factor-related protein 5. It is characterized by dark adaptation abnormalities, sub-retinal pigment epithelium lipid-rich material deposits, choroidal neovascularization, and chorioretinal atrophy. The typical onset is in the fifth or sixth decade of life.


name: Lymphoma by Working Formulation (Antiquated)


name: Grade 4 Alanine Aminotransferase Increased, CTCAE

description: >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal


Childhood Acute Leukemia

description: An acute leukemia that occurs during childhood.


Gastric Poorly Cohesive Adenocarcinoma

description: An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.  This category includes signet ring cell adenocarcinomas, adenocarcinomas that are composed of malignant cells resembling lymphocytes and histiocytes, and adenocarcinomas that are composed of malignant cells with deeply eosinophilic cytoplasm.


Grade 1 Photosensitivity, CTCAE

description: Painless erythema and erythema covering <10% BSA


Stage IIIA Gastric Carcinoma

description: Stage IIIA includes: (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Periventricular Leukomalacia, AE

description: An adverse event in a newborn characterized by a form of cerebral white matter injury usually seen in preterm infants that is characterized by necrotic degeneration or gliosis of white matter adjacent to the cerebral ventricles that may evolve into focal cysts.


Expected Adverse Event

description: Any adverse event associated with a medical product or procedure, whose nature and severity have been previously observed, identified in nature, severity, or frequency, and documented in the investigator brochure, investigational plan, protocol, current consent form, scientific publication, or in other relevant and reliable document. The old term Side Effect is retired and should not be used.


name: Grade 3 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Irritability, CTCAE

description: A disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition.


name: Grade 3 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Stage III Bone Sarcoma AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Grade 5 Pulmonary Fibrosis, CTCAE

description: Death


name: Grade 3 Spinal Cord Intra-Operative Injury, CTCAE


Grade 2 Chest Pain - Cardiac, CTCAE

description: Moderate pain; pain on exertion; limiting instrumental ADL; hemodynamically stable


Mitochondrial enzyme deficiency

description: A constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.


Grade 2 Ear Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Stage IIIC1 Cervical Cancer AJCC v9

description: Stage IIIC1 includes: TX, T0, T1-3, N1, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. M0: No distant metastasis. (from AJCC 9th Ed.)


Lymphoma, Low-Grade

description: An antiquated term that refers to a non-Hodgkin lymphoma with low grade histologic features.


name: Grade 2 Infertility and Sterility, CTCAE


name: Grade 2 Central Nervous System Necrosis, CTCAE

description: Moderate symptoms; corticosteroids indicated


name: Radiation-Induced Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is the result of exposure to ionizing radiation.


name: Grade 3 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Duodenal Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of stomach contents through the duodenum.


Grade 2 Testosterone Deficiency, CTCAE

description: Replacement therapy initiated


name: Grade 3 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Facial Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Stage IIA Cervical Cancer AJCC v7

description: Stage IIA includes: IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0).  T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Serious Adverse Event

description: Any expected or unexpected adverse event, related or unrelated to the intervention, occurring at any agent dose, any phase of product or procedure testing, that results in any of the following outcomes: death, a life-threatening adverse event, requires inpatient hospitalization (not required as part of the treatment) or prolongation of existing hospitalization, a persistent or significant disability or incapacity, or cancer, or a congenital anomaly or birth defect. Important medical events that may not result in the listed outcomes may be considered as serious when, based upon appropriate medical judgment, they represent significant hazards or potentially serious harm to the research subject or others and may require medical intervention to prevent one of the outcomes listed in this definition.


Grade 2 Uterine Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Grade 3 Radiculitis, CTCAE

description: Severe symptoms; limiting self care ADL


Childhood Benign Liver Neoplasm

description: A childhood neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Grade 5 Paranasal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acantholytic Actinic Keratosis

description: Actinic keratosis characterized by the presence of acantholysis of the dysplastic keratinocytes.


name: Treatment-Related Prostate Neuroendocrine Carcinoma

description: A prostate carcinoma with partial or complete neuroendocrine differentiation that results from the transformation of castration-resistant prostate adenocarcinoma following potent androgen-deprivation therapy. The prognosis is poor.


name: Pathologic Stage I Cutaneous Melanoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0); IB: (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Acute rheumatic pericarditis

description: Inflammation of the pericardium in acute rheumatic heart disease.


name: Squamous Cell Carcinoma of Unknown Primary

description: A squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


name: Grade 2 Proptosis and Enophthalmos, CTCAE


Malignant Abdominal Neoplasm

description: A primary or metastatic malignant neoplasm that affects the organs and structures of the abdomen.


Localized Gallbladder Carcinoma

description: A carcinoma that arises from the gallbladder and it has not spread to other anatomic sites.


Grade 2 Papulopustular Rash, CTCAE

description: Papules and/or pustules covering 10-30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL; papules and/or pustules covering > 30% BSA with or without mild symptoms


Bacterium-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific bacterium as the causative agent.


name: Stage I Pancreatic Cancer AJCC v6 and v7

description: Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Grade 2 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cotton or Jute Dust Exposure

description: Environmental, occupational, or consumer-based exposure to airborne cotton or jute fibers created during the manufacture, processing, or handling of these materials.


Grade 1 Trochlear Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Transitional cell cancer of the renal pelvis and ureter localized

description: Urothelial carcinoma of the renal pelvis or ureter that has not spread to adjacent tissues, regional lymph nodes, or distant anatomic sites.


Grade 3 Urostomy Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

description: A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular or squamous differentiation and giant cells resembling osteoclasts.


Non-Neoplastic Ureter Disorder

description: A non-neoplastic disorder affecting the ureter.


Grade 5 Portal Hypertension, CTCAE

description: Death


Tumor contained within organ capsule

description: A neoplasm surrounded by a fibrous capsule.


name: Childhood Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for childhood Hodgkin lymphoma based on the Ann Arbor classification criteria.