Grade 4 Postoperative Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Head Mass

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An abnormal growth located on the head.


name: Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Lip Or Perioral Area Intra-Operative Injury, CTCAE


Defective T-Cell Receptor Signaling

description: An indication that T-cell receptor (TCR)-dependent signaling pathways in a immunologic sample are compromised. TCR signaling defects lead to impaired development of T-lymphocytes and are usually caused by deletion or loss of function mutations affecting one or more proteins involved in TCR-dependent signaling pathways, including the subunits of the TCR complex.


Pancreatic Cancer by AJCC v8 Stage

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A term that refers to the staging of exocrine pancreatic cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to pancreatic ductal adenocarcinoma, acinar cell carcinoma, intraductal papillary mucinous neoplasm with associated invasive carcinoma, intraductal tubulopapillary neoplasm with associated invasive carcinoma, colloid carcinoma, mucinous cystic neoplasm with associated invasive carcinoma, solid pseudopapillary neoplasm, large cell neuroendocrine carcinoma, small cell neuroendocrine carcinoma, and pancreatoblastoma. Well-differentiated neuroendocrine tumors are not staged using this staging system. (from AJCC 8th Ed.)


Primary osteosarcoma of bone

description: A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It usually involves the long bones and predominantly affects adolescents and young adults. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs.


name: Grade 2 Brachial Plexus Intra-Operative Injury, CTCAE


Grade 3 Neonatal Fever, AE

description: An adverse event in a newborn characterized by fever, major change in baseline age-appropriate behavior and without resolution to symptomatic treatment.


name: Grade 4 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


name: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Chlamydia psittaci infection

description: A bacterial infection caused by Chlamydophila psittaci. Humans are infected by handling sick birds. The Chlamydiae cause respiratory infection manifests with fever, malaise, cough, dyspnea, sore throat, photophobia and headaches.


name: Decreased Time To Peak Drug Blood Concentration

description: Decreased time following drug administration at which the peak drug blood concentration occurs.


Grade 2 Hematosalpinx, CTCAE

description: Moderate bleeding; medical intervention indicated


name: Grade 2 Renal and Urinary Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Clinical Test Result

description: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition.


name: Grade 4 Bronchus Obstruction and Stenosis, CTCAE


Stage IVB Cervical Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


name: Grade 4 Other Sexual Reproductive Function, CTCAE


Neonatal Constipation, AE

description: An adverse event in a newborn characterized by irregular and infrequent or difficult evacuation of the bowels.


name: Grade 2 Small Bowel Perforation NOS, CTCAE


name: Recurrent Adult Diffuse Small Cleaved Cell Lymphoma

description: The reemergence of adult diffuse small cleaved cell lymphoma after a period of remission.


name: Phantom Pain Associated with Missing Limb, CTCAE


Adverse Event Attributed to Other Cause

description: An indication that an adverse event is causally related to an entity that is a not a disease- or research-related process nor a commercial product or investigational new drug (IND).


Advanced Neuroendocrine Tumor

description: A neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 3 Larynx Intra-Operative Injury, CTCAE


Grade 2 Adrenal Insufficiency, CTCAE

description: Moderate symptoms; medical intervention indicated


Refractory Gastric Carcinoma

description: Gastric carcinoma that does not respond to treatment.


name: Grade 2 Depressed Level of Consciousness, CTCAE

description: Sedation; slow response to stimuli; limiting instrumental ADL


Solid pseudopapillary neoplasm

description: A low-grade malignant neoplasm that arises from the exocrine pancreas. Rare cases arising from ectopic pancreatic tissue in the ovary have also been described. It is characterized by the presence of uniform cells that form solid and pseudopapillary patterns, cystic changes, and hemorrhage. It usually presents as an encapsulated, solitary, and lobulated mass. It occurs predominantly in young women. Complete removal of the tumor is curative in the majority of cases.


Grade 4 Aortic Injury, CTCAE

description: Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated


IOL dislocation

description: Displacement of the intraocular lens from the visual axis.


Grade 5 Gallbladder Fistula, CTCAE

description: Death


name: Low-CSD Melanoma, Superficial Spreading Melanoma Subtype

description: A cutaneous melanoma that develops on sun exposed sites with low cumulative sun damage (CSD). It is characterized by a prominent junctional and intraepidermal component with intraepidermal proliferation of individual atypical melanocytes and formation of nests of atypical melanocytes along the dermal-epidermal junction. The dermal component is composed of atypical melanocytes that fail to mature. The atypical melanocytes have large nuclei, prominent nucleoli, and eosinophilic or lightly pigmented cytoplasm. It is the most common melanoma subtype in the Western world.


Stage IIA1 Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, less than 4 cm in greatest dimension. (FIGO 2018)


Refractory Giant Cell Glioblastoma

description: Giant cell glioblastoma that is resistant to treatment.


Grade 1 Hyperkalemia, CTCAE

description: >ULN-5.5 mmol/L


Genitourinary System Carcinoma

description: A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma.


Toothache, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the tooth.


Grade 5 Ovarian Rupture, CTCAE

description: Death


name: Grade 5 Upper Gastrointestinal Hemorrhage, CTCAE

description: Death


name: Reproductive System and Breast Disorders - Other, Specify, CTCAE


name: Grade 1 Injection Site Reaction or Extravasation Changes, CTCAE


Anti-D Hemolytic Disease of the Newborn

description: A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against the D antigen, the most common Rhesus factor.


Non-Neoplastic Thoracic Disorder

description: A non-neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, pneumonia, and chronic obstructive pulmonary disease.


Splenic Rupture Related to Birth

description: Disruption of the spleen incurred during delivery.


name: Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

description: Urothelial carcinoma of the renal pelvis or ureter that has spread to adjacent tissues and/or regional lymph nodes but not to distant anatomic sites.


Sarcoma of the Extremity

description: A sarcoma that arises from the soft tissues or bones of the upper or lower extremity.


name: Grade 2 Visceral Arterial Ischemia, CTCAE

description: Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit


Fetal Hypoxia

description: Hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration.


name: Eye Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 3 Olfactory Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


Recurrent Urinary System Carcinoma

description: Reemergence of a urinary system carcinoma after a period of remission.


Severe Mosquito Bite Allergy

description: An EBV-positive NK-cell lymphoproliferative disorder characterized by high fever and intense local skin symptoms, including erythema, bullae, ulcers, skin necrosis, and deep scarring following mosquito bites. Patients have NK-cell lymphocytosis in the peripheral blood and an increased risk of developing hemophagocytic syndrome and progressing into overt NK/T-cell lymphoma or aggressive NK-cell leukemia in the longstanding clinical course. (WHO 2017)


name: Colon Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Uterine Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the uterus.


Grade 2 Ileal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Classical Hodgkin lymphoma type posttransplant lymphoproliferative disorder

description: A lymphoproliferative disorder that fulfills the criteria for classic Hodgkin lymphoma and arises as a result of post-transplant immunosuppression therapy. It is most often seen in renal transplant patients.


Unresectable Bladder Adenocarcinoma

description: Bladder adenocarcinoma that is not amenable to surgical resection.


Stage I Gallbladder Cancer AJCC v7

description: Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria or muscular layer.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Metastatic Digestive System Carcinoma

description: A carcinoma that arises from the gastrointestinal system and has metastasized to other anatomic sites.


Unresectable Meningioma

description: A meningioma that is not amenable to surgical resection.


name: Stage IV Adult Diffuse Large Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Personality Change, CTCAE

description: A disorder characterized by a conspicuous change in a person's behavior and thinking.


Spinal Cord Hamartoma

description: A hamartoma that occurs in the spinal cord.


name: Grade 4 Other Renal or Genitourinary, CTCAE


name: Childhood Cancer Stage by Toronto Guidelines v2

description: A term that refers to the staging of childhood cancers following the rules of the Toronto guidelines v2, 2019. The guidelines were developed to address the lack of consistent information on childhood cancer staging in population registries and are not intended to replace staging systems in clinical use. They include a two-tiered approach that provides less detailed criteria for registries with limited resources and/or limited data access (Tier 1) and more detailed criteria for better-resourced registries (Tier 2). They apply to acute lymphoblastic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, neuroblastoma, renal malignant tumors except renal cell carcinoma, rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, malignant bone tumors, retinoblastoma, hepatoblastoma, testicular germ cell tumors, ovarian germ cell tumors, astrocytoma, medulloblastoma and ependymoma. The following changes were noted to the original classification (v1, 2014): a staging system was no longer considered appropriate for acute myeloid leukemia; all renal tumors, with the exception of renal cell carcinomas, should use the endorsed staging systems for Wilms tumor; staging systems for osteosarcoma and Ewing sarcoma were combined into a single recommendation for all malignant bone tumors; a staging system was endorsed for astrocytomas; the S category (serum tumor markers) was confirmed as an integral part of TNM staging for testicular cancer in Tier 2 recommendations; and PRETEXT number was added to Tier 2 recommendations for hepatoblastoma. (adapted from Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 3 Congenital, Familial and Genetic Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Lymphoma, AIDS-Related

description: An aggressive lymphoma that develops in HIV-positive patients.  There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic.  These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas.  The prognosis is closely related to the severity of immunodeficiency.


name: Stage IV Appendix Neuroendocrine Tumor AJCC v7

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Grade 1 Other Blood and Bone Marrow, CTCAE


Rectal Ulcer, CTCAE

description: A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the rectum.


Cervical Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm that arises from the cervix. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


name: Gastric Antrum Carcinoma In Situ AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtype

description: A rare, mature T-cell lymphoma arising from the skin.


name: Grade 3 Non-Malignant Pericardial Effusion, CTCAE


Locally Advanced Urothelial Carcinoma

description: A urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Urothelial Carcinoma, High Grade

description: Urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


Grade 3 Edema Limbs, CTCAE

description: >30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care ADL


name: Grade 2 Stomach Intra-Operative Injury, CTCAE


name: Grade 2 Small Bowel NOS Intra-Operative Injury, CTCAE


Accidental Injuries

description: Unintentional trauma to the body.


Resectable Malignant Solid Neoplasm

description: Malignant solid neoplasm that is amenable to surgical resection.


Vaginal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures).


Congenital Vena Cava Abnormality

description: An abnormality of the superior or inferior vena cava that is present at birth. Representative examples include persistent left superior vena cava, absence of infrarenal inferior vena cava, or absence of the entire inferior vena cava.


Grade 3 Vestibular Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 4 Cranial Nerve III Intra-Operative Injury, CTCAE


name: Grade 2 Arachnoiditis and Meningismus and Radiculitis, CTCAE


Serum CEA Level Elevated

description: The amount of carcinoembryonic antigen present in a serum sample is elevated.


Grade 5 Pulmonary Valve Disease, CTCAE

description: Death


Post-Treatment Lyme Disease Syndrome

description: A constellation of symptoms lasting months to years reported by some Lyme disease patients who had undergone previous antibiotic therapy.


name: Childhood Langerhans Cell Histiocytosis with Risk Organ Involvement

description: Langerhans cell histiocytosis that occurs during childhood and involves the bone marrow, spleen, liver, or lung.


Grade 1 Rectal Fistula, CTCAE

description: Asymptomatic


Grade 1 Body Odor, CTCAE

description: Mild odor; physician intervention not indicated; self care interventions


Prostate Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the prostate gland.  Representative examples include acute and chronic prostatitis.


name: Grade 5 Cranial Nerve VII Neuropathy, CTCAE


name: Grade 5 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Adverse Event Associated with the Endocrine System


name: Grade 4 Nervous System Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Intraoperative Reproductive Tract Injury, CTCAE

description: Death


name: Grade 2 Lung Intra-Operative Injury, CTCAE


Stage IB Pancreatic Cancer AJCC v8

description: Stage IB includes: T2, N0, M0. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metanephric stromal tumor

description: A rare benign renal neoplasm composed of moderately cellular spindle cells. It occurs mostly in infancy and childhood.


name: Grade 5 Rectum Stricture or Stenosis, CTCAE


Extraocular Muscle Paresis, CTCAE

description: A disorder characterized by incomplete paralysis of an extraocular muscle.


Grade 1 Gastrointestinal Fistula, CTCAE

description: Asymptomatic


name: Recurrent Glioneuronal and Neuronal Tumors

description: The reemergence of glioneuronal and neuronal tumors after a period of remission.


Device Related Infection, CTCAE

description: A disorder characterized by an infectious process involving the use of a medical device.


Ipsilateral Nodule

description: A metastatic tumor nodule located in the same side of the organ in which the primary tumor occurred.


Grade 5 Nephrotic Syndrome, CTCAE

description: Death


Lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Hydrocephalus, CTCAE

description: Severe symptoms or neurological deficit; intervention indicated


name: Grade 2 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Joint Infection, CTCAE

description: A disorder characterized by an infectious process involving a joint.


Blood Cardiac Troponin I Increased

description: A laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen.


name: Grade 3 Trachea Intra-Operative Injury, CTCAE


name: Grade 2 Bronchus Obstruction and Stenosis, CTCAE


Miscellaneous Neoplasm

description: A benign or malignant neoplasm which is not further characterized.


Prolapse of Intestinal Stoma, CTCAE

description: A finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface.


name: Grade 2 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Urinary Frequency, CTCAE

description: A disorder characterized by urination at short intervals.


name: Grade 3 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

description: Severe symptoms; limiting self care ADL; hospitalization


Scrotal hernia

description: The protrusion of abdominal cavity contents into the scrotal sac.


Integumentary System Signs and Symptoms

description: Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument.


Stage I Cervical Cancer AJCC v6 and v7

description: Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Grade 1 Cranial Nerve XI Intra-Operative Injury, CTCAE


COVID-19-Associated Encephalitis

description: Encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Childhood Neurofibroma

description: A neurofibroma that occurs during childhood.


name: Recurrent Malignant Nongerminomatous Germ Cell Tumor

description: The reemergence of a malignant nongerminomatous germ cell tumor after a period of remission.


Grade 3 Rectal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Refractory Malignant Male Reproductive System Neoplasm

description: Malignant male reproductive system neoplasm that is resistant to treatment.


name: Urethra Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Extraocular Muscle Paresis, CTCAE

description: Bilateral paresis requiring head turning to see beyond central 60 degrees or double vision in central gaze


Grade 1 Vasculitis, CTCAE

description: Asymptomatic, intervention not indicated


Enterocolitis, CTCAE

description: A disorder characterized by inflammation of the small and large intestines.


name: Grade 2 Neonatal Pulmonary Hemorrhage, AE

description: An adverse event in a newborn characterized by hemorrhagic secretion in an endotracheal (ET) tube; without relevant increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation; requiring minor changes in care (e.g. increase in positive end-expiration pressure (PEEP)).


name: Ampulla of Vater Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The mitotic count is 2-20 per 10 HPF.


Advanced Lymphoma

description: Lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 5 Non-Infectious Wound Complication, CTCAE


Stage IIC Appendix Carcinoma AJCC v7

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades other organs or structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Otitis Media, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Chest Pain Along Left Anterior Axillary Line

description: The location of the chest pain is along the anterior axillary line on the left side.


Cervical Cancer by AJCC v9 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


Grade 2 Hiccups, CTCAE

description: Moderate symptoms; medical intervention indicated; limiting instrumental ADL


name: Blood and Lymphatic System Disorders, CTCAE


Childhood Schwannoma

description: A schwannoma that occurs during childhood.


Recurring Adverse Event

description: An adverse event that occurs and resolves during a cycle or course of medical intervention and then reoccurs in a later cycle or course.


name: Digestive System Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


Grade 1 Eyelid Function Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Methemoglobinemia, CTCAE

description: A disorder characterized by laboratory test results that indicate increased methemoglobin in the blood.


name: Childhood Hodgkin Lymphoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood Hodgkin lymphoma according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


name: Grade 2 Nervous System Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 2 Spinal Cord Intra-Operative Injury, CTCAE


Stage IIA1 Cervical Cancer AJCC v8

description: Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Refractory Neuroendocrine Carcinoma

description: Neuroendocrine carcinoma that does not respond to treatment.


Cutaneous Melanoma by AJCC v8 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system. This staging system does not apply to melanoma of the conjunctiva, melanoma of the uvea, mucosal melanoma arising in the head and neck, and mucosal melanoma of the urethra, vagina, rectum, and anus. (from AJCC 8th Ed.)


name: Pelvis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Grade 2 Small Intestinal Perforation, CTCAE

description: Invasive intervention not indicated


Dermal nerve sheath myxoma

description: A usually painless, slow growing benign tumor that most often arises from the extremities. It is characterized by the presence of abundant myxoid matrix and small epithelioid neoplastic Schwann cells.


Congenital Amegakaryocytosis

description: A rare disorder of infancy characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


name: Grade 2 Thyroid Intra-Operative Injury, CTCAE


name: Grade 2 Stoma GI Stricture or Stenosis, CTCAE


Grade 1 Duodenal Fistula, CTCAE

description: Asymptomatic


Ventricular Fibrillation, CTCAE 5.0

description: A disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles.


Gastroesophageal Junction Carcinoma

description: A carcinoma that arises from the gastroesophageal junction. The vast majority of cases are adenocarcinomas. Rare cases are neuroendocrine carcinomas.


name: Grade 5 Psychosis Including Hallucinations and Delusions, CTCAE


name: Grade 1 Cranial Nerve VIII Neuropathy, CTCAE


Cannabis dependence, episodic

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of episodic use.


Closed dislocation of hip

description: A closed dislocation of the hip.


name: Grade 5 Spleen Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Joint Intra-Operative Injury, CTCAE


Grade 4 Lymph Gland Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Metastatic Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site.


Grade 4 Hypocalcemia, CTCAE

description: Corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences


name: Grade 3 Cranial Nerve V Neuropathy, CTCAE


Grade 3 Dyspnea, CTCAE

description: Shortness of breath at rest; limiting self care ADL


Peripheral Ischemia, CTCAE

description: A disorder characterized by impaired circulation to an extremity.


name: Myelodysplastic Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia characterized by the absence of a markedly elevated white blood cell count in the peripheral blood.


Grade 3 Chronic Kidney Disease, CTCAE

description: eGFR or CrCl 29-15 ml/min/1.73 m2


name: Upper Extremity Vein Intra-Operative Injury, CTCAE


Poroid Hidradenoma

description: A poroma characterized by the presence of a single or several nodules of neoplastic cells forming solid and cystic areas in the dermis.


name: Non-Neoplastic Hematologic and Lymphocytic Disorder

description: A non-neoplastic disorder that arises from hematopoietic and lymphoid cells. It is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


Grade 3 Hypoparathyroidism, CTCAE

description: Severe symptoms; medical intervention or hospitalization indicated


name: Grade 5 Treatment Related Secondary Malignancy, CTCAE

description: Death


Stage II Urethral Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: For male penile urethra and female urethra: Tumor invades any of the following: corpus spongiosum, periurethral muscle. For prostatic urethra: Tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 1 Supraventricular Arrhythmia NOS, CTCAE


Mesonephric Hyperplasia

description: A hyperplasia of the mesonephric cells.


name: Stage IB Ampulla of Vater Cancer AJCC v7

description: Stage IB includes: T2, N0, M0. T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Corrosive injury

description: Destruction of tissue by a chemical substance.


Grade 4 Neonatal Bradyarrhythmia, AE

description: A bradyarrhythmia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.


name: Grade 4 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Contact lens overwear syndrome (disorder)

description: Ocular pain which may be very intense, accompanied by corneal epithelium damage, conjunctival injection, lacrimation, blepharospasm, photophobia and hazy vision following corneal edema caused by overwear of contact lenses, principally the PMMA type.


neuroendocrine carcinoma of anal canal

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


name: Grade 3 Restrictive Cardiomyopathy, CTCAE

description: Symptomatic heart failure or other cardiac symptoms, responsive to intervention; new onset of symptoms


Acral Melanoma

description: A cutaneous melanoma that arises from the palms, soles, and nails.


Grade 2 Bullous Dermatitis, CTCAE

description: Blisters covering 10-30% BSA; painful blisters; limiting instrumental ADL


name: Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8

description: Limited stage adult Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Burning Chest Pain

description: The sensation of chest pain described as an intense discomfort, similar to that experience as a result of a thermal burn, distinct from sharp, stabbing or aching, often related to nerves; sometimes used to describe gastric or esophageal pain.


Unresectable Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that is not amenable to surgical resection.


Intraoperative Head and Neck Injury

description: Damage to head and neck during a surgical procedure.


name: AIDS-Related Diffuse Small Cleaved Cell Lymphoma

description: A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of small cleaved lymphocytes.


Grade 3 Hypertriglyceridemia, CTCAE

description: >500 mg/dL-1000 mg/dL; >5.7 mmol/L-11.4 mmol/L


name: Bile Duct Mucinous Cystic Neoplasm, Low Grade

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of mild atypia.


Childhood Gliosarcoma

description: A gliosarcoma that occurs during childhood.


Grade 1 Radiculitis, CTCAE

description: Mild symptoms


Grade 5 Hepatic Hemorrhage, CTCAE

description: Death


name: Undifferentiated Carcinoma of Unknown Primary

description: An undifferentiated carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Grade 4 Wheezing, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Brain Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Parapsoriasis lichenoides

description: A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.


name: acute undifferentiated leukemia in relapse

description: The reemergence of acute undifferentiated leukemia after a period of remission.


Sweat Gland Tubular Carcinoma

description: An aggressive adenocarcinoma that arises from the sweat glands. It usually presents as a firm, erythematous nodular lesion in the axilla. Morphologically, it is characterized by the presence of tubular structures and apocrine differentiation.


Stage III Vulvar Cancer AJCC v8

description: Stage III includes: T1-T2, N1-N2c, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N1: Regional lymph node metastasis with one or two lymph node metastases each less than 5 mm, or one lymph node metastasis equal to 5 mm. N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. N2c: Lymph node(s) metastasis with extranodal extension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Reaction to Medicinal Component of Device

description: Any local or systemic adverse reaction to the medicinal component of a combination product.


Parathyroid chief-cell hyperplasia

description: A hyperplasia of the chief cells of the parathyroid gland.


name: Recurrent Platinum-Sensitive Endometrial Carcinoma

description: The reemergence of platinum-sensitive endometrial carcinoma after a period of remission.


name: Grade 3 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Lower Thigh Pain

description: A painful sensation in the distal thigh area.


name: Grade 3 Esophageal Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Grade 2 Vaginal Discharge, CTCAE

description: Moderate to heavy vaginal discharge; use of perineal pad or tampon indicated


Balloon cell nevus

description: An uncommon variant of melanocytic nevus. It presents as a small pigmented skin lesion. It is characterized by the presence of large melanocytes with clear, foamy or finely vacuolated cytoplasm. It may recur if it is not completely excised.


Endocrine Therapy Toxicity

description: Indicates that a toxicity adverse effect has been experienced during endocrine drug treatment.


Microcyst

description: A tiny cyst that is usually identified by microscopic examination in a tissue specimen.


Sacral Myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


Grade 2 Neonatal Sinus Bradycardia, AE

description: An adverse event in a newborn characterized by persistent sinus bradycardia; no change in age-appropriate behavior; requiring minor care changes (e.g. concomitant medication adapted, intermittent increase of fraction of inspired oxygen (FiO2)).


Gallbladder Perforation, CTCAE 5.0

description: A disorder characterized by a rupture in the gallbladder wall.


name: Grade 4 Pancreatic Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 5 Hepatic Infection, CTCAE

description: Death


name: Grade 3 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Anorectal Infection, CTCAE

description: Death


Metastatic Neoplasm to the Bladder

description: The spread of a malignant neoplasm to the urinary bladder wall from an adjacent or distant anatomic site.


Grade 5 Tracheal Hemorrhage, CTCAE

description: Death


name: Stage y-III Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Incomplete excision of the tumor (gross or microscopic extension beyond the resection margins). Involved abdominal lymph nodes, including necrotic tumor or chemotherapy-induced changes. Tumor rupture before or intraoperatively. Tumor has penetrated the peritoneal surface. Tumor thrombi present at resection margins. Surgical biopsy prior to resection (does not include needle biopsy). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Hypomagnesemia, CTCAE

description: <0.9-0.7 mg/dL; <0.4-0.3 mmol/L


name: Long-Term Effects Secondary to Cancer Therapy in Children


name: Lugano Classification Stage III Adult Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Prolapse of Urostomy, CTCAE

description: A finding of displacement of the urostomy.


Acute Submassive Pulmonary Embolism

description: Acute pulmonary embolism with evidence of right ventricular dysfunction, but not associated with systemic hypotension.


name: Enterochromaffin-Like Cell Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells.


Colonic Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site.


name: Invasive Conventional Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


name: Grade 4 Small Bowel Perforation NOS, CTCAE


Stage IVB Gallbladder Cancer AJCC v7

description: Stage IVB includes: (Any T, N2, M0); (Any T, Any N, M1).  N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


name: Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Female Reproductive System

description: The spread of a malignant neoplasm to the female reproductive system from an adjacent or distant anatomic site.


name: IgM Monoclonal Gammopathy of Undetermined Significance, Not Otherwise Specified

description: A subtype of IgM monoclonal gammopathy of undetermined significance that includes cases associated with MYD88 mutation and cases associated with the presence of monoclonal B-lymphocytes without the presence of abnormal lymphoplasmacytic aggregates that are diagnostic of lymphoplasmacytic lymphoma or other small B-lymphocytic neoplasms.


name: Grade 5 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Folliculitis, CTCAE

description: A disorder characterized by inflammation or infection of the hair follicles.


Chronic Total Occlusion Vessel

description: A longstanding, complete blockage of a vessel. (ACC)


name: Grade 2 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Hematoma of rectus sheath

description: A collection of blood in the rectus sheath due to disruption of the superior or inferior epigastric arteries, which may present following direct trauma to the rectus abdominis muscle or anticoagulation therapy.


name: Malignant Germinative Follicular Epithelium Neoplasm

description: A malignant neoplasm that arises from germinative follicular epithelial cells.


name: Ampulla of Vater Cancer by AJCC v7 Stage

description: A term that refers to the staging of ampulla of Vater cancer according to the American Joint Committee on Cancer, 7th edition.


name: Recurrent Childhood Central Nervous System Neoplasm

description: The reemergence of central nervous system neoplasm in childhood after a period of remission.


Grade 4 Conduction Disorder, CTCAE

description: Life-threatening consequences


name: Grade 2 Upper Extremity Artery Intra-Operative Injury, CTCAE


Grade 4 Anal Necrosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 1 Cranial Nerve VII Neuropathy, CTCAE


Hypothyroidism, CTCAE

description: A disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.


Grade 3 Stroke, CTCAE

description: Severe neurologic deficit; limiting self care ADL; hospitalization


name: Grade 2 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


COVID-19-Associated Stroke

description: Cerebrovascular accident caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage 0 Uterine Corpus Cancer

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas.  FIGO no longer includes Stage 0 (Tis). (AJCC 7th ed.)


name: Grade 4 Bronchus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Pulmonary Edema, CTCAE

description: Severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL


name: Metastatic Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


Grade 4 Laryngeal Obstruction, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Hirsutism, CTCAE

description: In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair


name: Grade 3 Dental and Teeth and Peridontal Pain, CTCAE


Stage IVB Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to distant organs. (FIGO 2018)


name: Grade 1 Brain Intra-Operative Injury, CTCAE


name: Cervical Papillary Squamous Cell Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


Intraoperative Hemorrhage

description: Uncontrolled bleeding during a surgical procedure.


name: Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma that arises from the bone and occurs during childhood.


name: Grade 4 Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Refractory Primary Amyloidosis

description: Primary amyloidosis that does not respond to treatment.


name: Conjunctiva Intra-Operative Injury, CTCAE


name: Grade 5 Other Dermatology or Skin, CTCAE


Plasma Kallikrein Deficiency

description: A coagulation disorder characterized by the partial or complete absence of plasma-type kallikrein activity in the blood.


name: Grade 2 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Nipple Deformity, CTCAE

description: A disorder characterized by a malformation of the nipple.


Lactation Disorder, CTCAE

description: A disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males.


Grade 5 Ventricular Fibrillation, CTCAE

description: Death


name: Grade 2 Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Childhood Refractory Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that does not respond to treatment.


Factor VII Inactivation

description: Presence of inactivating antibodies to factor VII in the blood.


Intraoperative Urinary System Injury

description: Damage to any part of the urinary system during a surgical procedure.


Blast Injuries

description: The result of physical trauma sustained in an explosion.


Grade 3 Conjunctivitis, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Grade 2 Urethral Infection, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Discoid Rash

description: A disc-shaped patch(es) of skin inflammation that is red, raised, and scaly; it typically develops on the face, scalp, and neck, and often leaves scars and dyspigmentation as a result of postinflammatory hyperpigmentation.


Grade 4 Perforation Bile Duct, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 2 Facial Muscle Weakness, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Adult Hodgkin Lymphoma

description: Hodgkin lymphoma occurring in adults.


Signet Ring Cell/Histiocytoid Carcinoma

description: A rare aggressive adnexal carcinoma preferentially affecting the eyelid and histopathologically resembling a metastatic lobular carcinoma of the breast and/or some adenocarcinomas arising in the gastrointestinal tract. (WHO 2018)


benign mature teratoma of pancreas

description: A mature teratoma that arises from the pancreas.


name: Recurrent Low Grade Adult Non-Hodgkin's Lymphoma


Early Prosthetic Valve Endocarditis

description: Prosthetic valve endocarditis that occurs days to weeks after surgery.


Advanced Pancreatic Carcinoma

description: Pancreatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Meningohydroencephalocele

description: A congenital neural tube closure defect resulting in protrusion of the brain, the meninges, and the ventricular system through an opening in the skull, usually involving the squamous part of the occipital bone..


Skin squamous cell carcinoma metastatic

description: Squamous cell carcinoma of the skin which has spread to other anatomic sites.


Confusion, CTCAE 5.0

description: A disorder characterized by a lack of clear and orderly thought and behavior.


Grade 2 Cough, CTCAE

description: Moderate symptoms, medical intervention indicated; limiting instrumental ADL


name: Grade 4 Cerebral Artery Intra-Operative Injury, CTCAE


Refractory Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is resistant to treatment.


name: Grade 1 Cerebrospinal Fluid Leakage, CTCAE

description: Post-craniotomy: asymptomatic; Post-lumbar puncture: transient headache; postural care indicated


name: Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Chest Pain Along Midclavicular Line

description: The location of the chest pain is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.


High Grade Osteosarcoma

description: An aggressive osteosarcoma with high-grade morphological features. This category includes high-grade surface osteosarcoma and conventional osteosarcoma.


name: Grade 2 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Poorly Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of poorly differentiated malignant cells.


name: Grade 3 Duodenum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Invasive Nested Urothelial Carcinoma

description: Invasive urothelial carcinoma characterized by a nested growth pattern.


name: Grade 3 Bronchus Obstruction and Stenosis, CTCAE


Sickle cell-thalassemia disease

description: Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.


Unfavorable Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis.


Primary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that occurs in the absence of physiological stimuli.


Stage IVB Osteosarcoma AJCC v7

description: Stage IVB includes: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N1: Regional lymph node metastasis.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


name: Grade 2 Muscle Intra-Operative Injury, CTCAE


name: Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Prostatic Hemorrhage, CTCAE

description: Death


Lower Ribs Pain

description: A sensation of discomfort emanating from the inferiormost (verterbrochondral or vertebral) ribs.


Hereditary Angioedema Types I and II

description: Autosomal dominant inherited disorders characterized by abnormalities of C1 inhibitor. Patients present with swelling of the skin, subcutaneous tissues, and mucosa sites. In type I hereditary angioedema, the plasma levels of C1 inhibitor are decreased. In type II hereditary angioedema, the C1 inhibitor is dysfunctional and its plasma levels may be normal or elevated.


Grade 2 Portal Hypertension, CTCAE

description: Decreased portal vein flow


name: Grade 4 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Uterine Corpus Cancer by AJCC v7 Stage

description: A term that refers to the staging of uterine corpus cancer (carcinoma or carcinosarcoma) according to the American Joint Committee on Cancer, 7th edition.


Grade 1 Penile Infection, CTCAE

description: Localized, local intervention indicated


Injury To Carotid Artery, CTCAE

description: A finding of damage to the carotid artery.


Recurrent Malignant Bone Neoplasm

description: Reemergence of a malignant bone neoplasm after a period of remission.


name: Gallbladder Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma

description: A mucinous cystic neoplasm that arises from the gallbladder and it is associated with an invasive carcinomatous component.


name: Sporadic Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is not caused by inherited genetic mutations.


Carcinoid tumor of the liver

description: An extremely rare, well differentiated neuroendocrine neoplasm arising from the liver. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation.


Grade 2 Glucose Intolerance, CTCAE

description: Symptomatic; dietary modification or oral agent indicated


Voice Alteration

description: Change in the sound and/or speed of the voice. Causes include laryngeal polyp, laryngitis, laryngeal carcinoma, throat carcinoma, Parkinson's disease, multiple sclerosis, stroke, hypothyroidism, oral surgery, tracheostomy, tracheal injury, and laryngeal injury.


Grade 4 Anal Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Mediastinal Infection, CTCAE

description: A disorder characterized by an infectious process involving the mediastinum.


Grade 3 Sinusitis, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Malaise, CTCAE

description: Uneasiness or lack of well being


name: TdT Positive Acute Lymphoblastic Leukemia


Anoxia

description: Absence or reduction of oxygen in body tissue.


Adult Gliosarcoma

description: A gliosarcoma occurring in adults.


name: Grade 1 Pancreas Intra-Operative Injury, CTCAE


Stage II Ureter Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Reactogenicity

description: An expected set of reactions that may occur soon after injection of a vaccine. These expected adverse reactions are a physical manifestation of the inflammatory response to the vaccine.


Mosquito-borne hemorrhagic fever

description: A group of viral illnesses that are vectored by mosquitoes, and that are characterized by increased susceptibility to bleeding diatheses.


Hypomyelinating Leukodystrophy-22

description: An autosomal dominant condition caused by mutation(s) in the CLDN11 gene, encoding claudin-11.  It is characterized by global developmental delay, mild impaired intellectual development, limited ability to walk, and hypomyelinating leukodystrophy on MRI.


name: Grade 2 Artery Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Intraoperative Breast Injury, CTCAE

description: Primary repair of injured organ/structure indicated


name: congenital renal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the kidney.


name: Grade 2 Cerebrospinal Fluid Leakage, CTCAE

description: Post-craniotomy: moderate symptoms; medical intervention indicated; Post-lumbar puncture: persistent moderate symptoms; blood patch indicated


Grade 5 Neonatal Edema, AE

description: An edema adverse event in a newborn which results in death.


Craniotubular Hyperostosis

description: A group of sclerosing bone dysplasias characterized by pronounced sclerosis of the cranial vault and the long bones, resulting in increased cortical bone density. Most cases are caused by mutation(s) in the SOST or LRP5 genes, encoding sclerostin and low-density lipoprotein receptor-related protein 5, respectively. Other genes have been implicated, and some cases have been described, but do not yet have identified genetic mutations.


name: Hepatic Artery Intra-Operative Injury, CTCAE


Grade 5 Papulopustular Rash, CTCAE

description: Death


name: Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


name: Stage IB Gestational Trophoblastic Tumor AJCC v7

description: Stage IB includes: T1, M0, Risk factors: high risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Premature Ventricular Contraction, CTCAE


Grade 1 Vaginal Fistula, CTCAE

description: Asymptomatic


name: Major Visceral Artery Intra-Operative Injury, CTCAE


Disseminated carcinoma

description: Carcinoma that is spread throughout the body.


Insomnia due to organic factors

description: Insomnia as a result of a physiological cause.


name: Grade 3 Urinary Frequency or Urgency, CTCAE


Congenital kyphosis

description: An abnormally increased curvature of the thoracic portion of the spine that is present at the time of birth.


name: Human Papillomavirus-Related Malignant Neoplasm in AIDS Patient

description: A malignant neoplasm caused by human papillomavirus in an a patient with a history of AIDS.


name: Fallopian Tube Intra-Operative Injury, CTCAE


Hypocalcemia, CTCAE

description: A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood.


Metastatic Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread from its original site of growth to another anatomic site.


Grade 3 Scrotal Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 5 Pneumothorax, CTCAE

description: Death


Tiring Pain

description: A sensation of discomfort or distress that renders an individual weary and without energy.


name: Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Reproductive System and Breast Disorders, CTCAE


name: Alkylating Agent-Related Acute Myeloid Leukemia

description: Acute myeloid leukemia occurring as late complication of prior therapy with alkylating agents.


name: Invasive Bladder Large Nested Urothelial Carcinoma

description: A rare invasive bladder urothelial carcinoma characterized the presence of medium to large nests of malignant cells.


name: Complication of labor and delivery, unspecified

description: The occurrence of a pregnancy complication during childbirth, which includes both labor (the process of childbirth) and delivery (the birth itself).


Fibromyxolipoma

description: A benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue and extensive myxoid change.


Salt-Wasting 21-Hydroxylase Deficiency

description: A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


name: Grade 2 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Appendix Mucinous Cystadenoma

description: A cystically dilated epithelial neoplasm arising from the appendix.  It is characterized by the presence of a cystic structure that is filled with mucus.


name: Hodgkin's disease, nodular sclerosis of lymph nodes of multiple sites

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Grade 3 Gastroparesis, CTCAE

description: Weight loss >=20% from baseline; tube feeding or TPN indicated; elective operative intervention indicated


name: Metastatic Bladder Small Cell Neuroendocrine Carcinoma

description: Bladder small cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Prostate Cancer by Whitmore-Jewett Stage

description: A term that refers to the staging of prostate carcinoma according to the Whitmore-Jewett staging system.


name: Grade 3 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Injury To Inferior Vena Cava, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Chylothorax, CTCAE

description: A disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity.


name: Small Bowel Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Clinical Stage II Cutaneous Melanoma AJCC v8

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Grade 4 Thorax Soft Tissue Necrosis, CTCAE


name: Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA

description: Chronic eosinophilic leukemia characterized by the rearrangement of the PDGFRA gene, most often resulting in the formation of FIP1L1-PDGFRA fusion transcripts.


Suicidal Ideation, CTCAE

description: A disorder characterized by thoughts of taking one's own life.


name: Childhood Acute Lymphoblastic Leukemia by Toronto Guidelines v2

description: A term that refers to the staging of childhood acute lymphoblastic Leukemia according to the Toronto childhood cancer staging guidelines v2.


name: Grade 5 Social Circumstances - Other, Specify, CTCAE

description: Death


Angiosarcoma recurrent

description: The reemergence of angiosarcoma after a period of remission.


Glioblastoma by Gene Expression Profile

description: Classification of glioblastoma into molecular subtypes as defined by gene expression profiling.


Metastatic Midgut Neuroendocrine Tumor

description: A midgut neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


Grade 1 Chylothorax, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Fluid Discharge

description: The pouring forth of a fluid.


name: Grade 3 Uterus Stricture or Stenosis, CTCAE


Stage III Anal Cancer AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T4, N0, M0); IIIC: (T3, N1, M0); (T4, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. T3: Tumor larger than 5 cm. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


Photophobia, CTCAE 5.0

description: A disorder characterized by fear and avoidance of light.


Grade 1 Memory Impairment, CTCAE

description: Mild memory impairment


name: Grade 5 Spermatic Cord Perforation, CTCAE


Primary acquired melanosis

description: A spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. The lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. They usually affect middle-aged and elderly Caucasians. (WHO 2018)


Meningeal Gliomatosis

description: Diffuse or multifocal infiltration of the meninges by malignant glioma.


Mediastinal Hemorrhage

description: Bleeding originating from the mediastinum.


name: Upper Airway Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 2 Middle Ear Inflammation, CTCAE

description: Serous otitis, medical intervention indicated


Grade 5 Hypoxia, CTCAE

description: Death


name: Grade 2 Biliary Tree Infection with Unknown Absolute Neutrophil Count, CTCAE


Gallbladder Goblet Cell Adenocarcinoma

description: An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


Post-Study Adverse Event

description: An adverse event that occurred after the patient had completed a clinical study (including any protocol-required post-treatment follow-up).


name: High Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of small neuroendocrine cells in the affected glands.


Grade 3 Uterine Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Locally Advanced Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread to nearby tissues or lymph nodes.


Grade 4 Infantile Apnea, AE

description: An apneic adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; (semi-)urgent intubation required.


Intraoperative Respiratory Injury

description: Damage to the respiratory system during a surgical procedure.


Pleural Infection, CTCAE

description: A disorder characterized by an infectious process involving the pleura.


name: Grade 2 CNS Necrosis and Cystic Progression, CTCAE


Grade 5 Ileal Perforation, CTCAE

description: Death


Grade 3 Breast Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Monomorphic Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed lymphocytes or plasma cells.  It includes two variants: monomorphic B-cell and monomorphic T/NK cell post-transplant lymphoproliferative disorders.


Grade 4 Respiratory Failure, CTCAE

description: Life-threatening consequences; urgent intervention, intubation, or ventilatory support indicated


Grade 4 Oral Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 1 Laryngopharyngeal Dysesthesia, CTCAE

description: Mild symptoms; no anxiety; intervention not indicated


name: Grade 4 Lower Extremity Soft Tissue Necrosis, CTCAE


Grade 1 Spasticity, CTCAE

description: Mild or slight increase in muscle tone


Zoonotic Spillover

description: Transmission of an infectious disease from a reservoir vertebrate population with a high pathogen prevalence coming into contact with a naive human population.


name: Grade 5 Trachea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Lower Extremity Vein Intra-Operative Injury, CTCAE


name: Pathologic Stage IV Retinoblastoma AJCC v8

description: Stage IV includes: Any pT, Any N, cM1 or pM1, Any H. cM1: Distant metastasis without microscopic confirmation. pM1: Distant metastasis with microscopic confirmation. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


EBV-Associated Smooth Muscle Tumor

description: A rare smooth muscle neoplasm of uncertain biological potential. It is associated with Epstein-Barr virus infection and seen in patients with immunodeficiency, including primary immunodeficiency, HIV/AIDS infection, and post-transplant immunosuppression.


Grade 5 Soft Tissue Infection, CTCAE

description: Death


name: Thoracic Duct Intra-Operative Injury, CTCAE


Grade 3 Bronchial Stricture, CTCAE

description: Shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)


Locally Advanced Carcinoma

description: A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Chest Pain Along Left Middle Sternal Border

description: The location of the chest pain is along the left middle border of the sternum.


name: Grade 1 Pharynx Intra-Operative Injury, CTCAE


Grade 5 Oral Cavity Fistula, CTCAE

description: Death


Myocardial degeneration

description: Degeneration of myocardial tissue.


name: Grade 2 Cervical Spine Range of Motion, CTCAE


Astler-Coller C2 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Gastrinoma, malignant

description: A gastrin-producing neuroendocrine tumor.  It is characterized by inappropriate secretion of gastrin and associated with Zollinger Ellison syndrome.  It displays vascular invasion and metastasizes to other anatomic sites.


name: Congenital Defects of Phagocyte Number, Function, or Both

description: A group of diseases or disorders caused by genetic defects within the immune system and comprising: Congenital neutropenia; Defects of motility; Defects of respiratory burst; and other nonlymphoid defects.


Neonatal Convulsion, AE

description: An adverse event in a newborn characterized by sudden, involuntary, rapid rhythmic or stereotyped skeletal muscular contraction.


Grade 1 Ovarian Rupture, CTCAE

description: Asymptomatic clinical or diagnostic observations only; intervention not indicated


Megakaryocytic Neoplasm

description: A neoplasm affecting cells of the megakaryocytic lineage.


Grade 4 Neonatal Convulsion, AE

description: An adverse event in a newborn characterized by suspected seizures with life-threatening consequences (e.g. need for ventilation); suspected status epilepticus (greater than 30 minutes of convulsions within any 60 minute period) despite multiple anti-seizure drugs.


Grade 1 Esophageal Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Pyramidal Tract Syndrome, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Grade 1 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


name: Grade 2 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 1 Blood Lactate Dehydrogenase Increased, CTCAE

description: >ULN


Resin Fume Exposure

description: Environmental, occupational, or consumer-based exposure epoxy compounds and other volatile chemicals associated with production and handling of resins (liquid plastics).


Grade 3 Gastric Necrosis, CTCAE

description: Inability to aliment adequately by GI tract; invasive intervention indicated


name: Grade 2 Tongue Intra-Operative Injury, CTCAE


Acidosis, CTCAE

description: A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues.


name: Chronic Cutaneous Graft Versus Host Disease

description: Chronic graft versus host disease (GvHD) occurring in the skin.


Injury of bronchus

description: Trauma to the lung bronchi.


Malignant melanoma in junctional nevus

description: A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin.


name: Childhood Malignant Bone Neoplasm by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood malignant bone neoplasm according to the Toronto childhood cancer staging guidelines v2. Staging is the same for both tiers (tier 1 and 2).


name: Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


name: Grade 5 Pleura Infection with Unknown Absolute Neutrophil Count, CTCAE


description: A rare mucinous cystadenocarcinoma that arises from the paratesticular structures.


name: Grade 5 Pharynx Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Serum Hypertriglyceridemia, CTCAE


Recurrent Cancer of Gallbladder

description: The reemergence of gallbladder carcinoma after a period of remission.


Grade 5 Mediastinal Infection, CTCAE

description: Death


name: Grade 1 Outer Ear Pinna Intra-Operative Injury, CTCAE


INR Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood.


Orbivirus infection

description: An infection that is caused by Orbivirus.


Phlebitis, CTCAE

description: A disorder characterized by inflammation of the wall of a vein.


name: Grade 1 Pancreatic Endocrine Glucose Intolerance, CTCAE


Unclassified Hepatocellular Adenoma

description: A hepatocellular adenoma without distinguished morphologic characteristics or known molecular abnormalities.


name: Grade 4 Eye Disorders - Other, Specify, CTCAE

description: Sight-threatening consequences; urgent intervention indicated; best corrected visual acuity of 20/200 or worse in the affected eye


name: Grade 1 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


name: Grade 2 Cranial Nerve II Intra-Operative Injury, CTCAE


Grade 5 Jejunal Fistula, CTCAE

description: Death


Gastric Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the stomach.


Grade 4 Gastric Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Congenital arteriovenous malformation of gastrointestinal tract

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the gastrointestinal tract.


Serum Amylase Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen.


Grade 2 Fetal Growth Retardation, CTCAE

description: <10% percentile of weight for gestational age


name: Grade 2 Upper Gastrointestinal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Grade 2 Phantom Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Increased Fibroblast Growth Factor Pathway Activation

description: A finding indicating increases in fibroblast growth factor (FGF) activity, activation of FGF-dependent pathways and proliferation of cells in a cellular sample.


Adverse event following immunization

description: Any unfavorable or unintended symptom, sign, or disease including an abnormal laboratory finding) temporally associated with the previous administration of vaccine(s) that may or may not be considered related to the vaccine administration. Such events can be intervention related, dose related, route related, patient related, or caused by an interaction with other product(s) or procedure(s).


name: Grade 3 Non-Malignant Pleural Effusion, CTCAE


Grade 1 Hoarseness, CTCAE

description: Mild or intermittent voice change; fully understandable; self-resolves


Tracheostomy Site Bleeding, CTCAE

description: A disorder characterized by bleeding from the tracheostomy site.


Contact dermatitis caused by acid

description: Contact dermatitis caused by exposure to acids.


Congenital His bundle tachycardia

description: A congenital disorder characterized by an electrocardiographic finding of tachycardia that affects neonates and infants. It results from an increased automaticity in the atrioventricular node and His bundle.


Extracranial Solid Neoplasm

description: A solid neoplasm involving any anatomic site other than the brain.


name: Grade 4 Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Tumor Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Childhood Ganglioneuroma

description: A ganglioneuroma that occurs during childhood.


High Metal Ion Levels

description: High blood or serum levels of ions which are attributed to one or more medical devices used, such as but not limited to Co, Cr, Ti, Ni, Mo.


Pancreatic Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures).


Adenocarcinoma endometrial recurrent

description: The reemergence of endometrioid adenocarcinoma after a period of remission.


Surgical Ciliated Cyst

description: A rare cyst that results from traumatic (usually surgical) implantation of respiratory epithelium in the jaw bones.


name: Grade 2 Intraoperative Head and Neck Injury, CTCAE

description: Partial resection of injured organ/structure indicated


name: Myelodysplastic/Myeloproliferative Neoplasm Post Cytotoxic Therapy

description: A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders.


name: Adult Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during adulthood.


name: Grade 5 Neck Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Unresectable Mucosal Melanoma

description: Mucosal melanoma that is not amenable to surgical resection.


name: Duodenum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Shingles, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated; limiting self-care ADL


name: Grade 2 Fever Without Neutropenia, CTCAE


Childhood Malignant Bone Neoplasm

description: A malignant neoplasm that affects the bone or articular cartilage and occurs during childhood.


name: Metastatic malignant neoplasm to soft tissues

description: A malignant neoplasm that has spread to the soft tissues from another anatomic site.


Grade 1 Colonic Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Cranial Nerve III Neuropathy, CTCAE


name: Grade 1 Gastrointestinal Leak NOS, CTCAE


name: Grade 5 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Uterine Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


A2/3 Hydronephrosis

description: Antenatal hydronephrosis with the following clinical findings: 1) an anterior-posterior renal pelvis diameter (APRPD) of greater than or equal to 7mm at less than 28 weeks, 2) greater than or equal to10 mm at greater than or equal to 28 weeks, or 3) any one of the following findings: a)dilation of peripheral calyces, b) abnormal parenchymal thickness or appearance, c) visibly dilated ureter, d) an abnormal bladder, or e) the presence of oligohydramnios suspected to be related to the urinary tract. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


Laryngospasm, CTCAE

description: A disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords.


name: Grade 4 Fallopian Tube Hemorrhage, CTCAE


Grade 4 Otitis Externa, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Carcinoma Unspecified Site

description: Carcinoma in which the site of involvement is not specified.


Locally Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread to nearby tissues or lymph nodes.


name: Grade 4 Flashing Lights and Floaters in Vision, CTCAE


Grade 2 Phlebitis Infective, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stage I Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Grade 3 Brain Intra-Operative Injury, CTCAE


name: Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage II Esophageal Cancer AJCC v7

description: Stage II includes: For squamous cell carcinoma: IIA (T2-3, N0, M0, G1, GX, Tumor location: Upper, middle); (T2-3, N0, M0, G2-3, Tumor location: Lower, X); IIB (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIA (T2, N0, M0, G3); IIB (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Acute Myeloid Leukemia with STAT5B-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of STAT5B-RARA fusion protein.


Grade 2 Ventricular Arrhythmia, CTCAE

description: Non-urgent medical intervention indicated


Posterior Subcapsular Cataract Grade 2

description: A stage of posterior subcapsular cataract characterized by 30% of the posterior capsule obscured by opacity. (Modified LOCS II)


Hypophysitis, CTCAE

description: A disorder characterized by inflammation and cellular infiltration of the pituitary gland.


Grade 5 Hemorrhoidal Hemorrhage, CTCAE

description: Death


name: Grade 3 Investigations - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Recurrent T-Cell and NK-Cell Neoplasm

description: The reemergence of T-cell and NK-cell neoplasm after a period of remission.


Splenic Infection, CTCAE

description: A disorder characterized by an infectious process involving the spleen.


ASS1 Gene Deficiency

description: A genetic finding indicating that low expression of the ASS1 gene has been detected in a sample.


name: Blood and Lymphatic System Disorders - Other, Specify, CTCAE


name: Grade 3 Intraoperative Hemorrhage, CTCAE

description: Postoperative invasive intervention indicated; hospitalization


Cannabis dependence, continuous

description: Physical and psychological dependence on the drug cannabis, which is associated with a pattern of continuous use.


Creatinine Increased, CTCAE

description: A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen.


Skin tumor of neural origin

description: A peripheral nervous system neoplasm that arises from the dermis.


Grade 2 Pulmonary Fibrosis, CTCAE

description: Evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25-50% associated with hypoxia


Grade 4 Myasthenia Gravis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Other Sexual Reproductive Function, CTCAE


Locally Advanced Gastric Adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 4 Spine Kyphosis or Lordosis, CTCAE


name: Grade 2 Peritoneal Cavity Intra-Operative Injury, CTCAE


Anal Canal Neuroendocrine Tumor G1

description: A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


name: Grade 5 Intraoperative Urinary Injury, CTCAE

description: Death


name: Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the intrahepatic or extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Grade 3 Gastrointestinal Pain, CTCAE

description: Severe pain; limiting self care ADL


Locally Advanced Sarcoma

description: Sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 4 Gallbladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Hypohidrosis, CTCAE

description: Death


name: Childhood EBV-Associated Smooth Muscle Tumor

description: An EBV-associated smooth muscle tumor that occurs during childhood.


Childhood Pilomatricoma

description: A pilomatricoma that occurs during childhood.


name: Locally Advanced Unresectable Bone Sarcoma

description: A bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Borderline Fallopian Tube Neoplasm

description: A rare epithelial tumor arising from the fallopian tube without definitive morphologic characteristics of malignancy.  This category includes borderline mucinous and serous neoplasms and borderline endometrioid tumor.


name: Grade 2 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Recurrent Endometrial Serous Adenocarcinoma

description: The reemergence of endometrial serous adenocarcinoma after a period of remission.


name: Platinum-Refractory Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Haptoglobin Decreased, CTCAE

description: A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.


Mild Adverse Event

description: An experience that is usually transient, and requires no special treatment or intervention. The event does not generally interfere with usual daily activities. Includes transient laboratory test alterations.


Stage IV Skin Cancer

description: Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T Any, N3, M0); (T4, N Any, M0); (T Any, N Any, M1).  T1: Tumor 2 cm or less in greatest dimension with less than two high-risk features.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  T3: Tumor with invasion of maxilla, mandible, orbit, or temporal bone.  T4: Tumor with invasion of skeleton or perineural invasion of skull base.  N0: No regional lymph node metastasis.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M1: Distant metastases.  (AJCC 7th Ed.)


Sebaceoma

description: A benign neoplasm characterized by sebaceous cell differentiation. It arises from the dermis and typically affects the face and neck.


Breast Papillary Neoplasm

description: A benign or malignant papillary neoplasm that arises from the breast.  It is characterized by the presence of epithelial proliferations that are supported by fibrovascular cores.  Representative examples are intraductal papilloma and papillary carcinoma.


name: Grade 2 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


name: Grade 2 Artery NOS Intra-Operative Injury, CTCAE


name: Castleman Disease, Hyaline-Vascular Type

description: The commonest type of Castleman disease. It is seen most commonly in the mediastinum. Histologically this is characterized by hyalinized germinal centers surrounded by small lymphocytes in a concentric fashion, giving an onion skin appearance.


name: Invasive Bladder Giant Cell Urothelial Carcinoma

description: An invasive urothelial carcinoma of the bladder with giant cells.


Grade 1 Hypothyroidism, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Spinal Cord Compression, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 1 Urinary Tract Obstruction, CTCAE


Childhood Classic Hodgkin Lymphoma

description: Classic Hodgkin lymphoma that occurs during childhood.


name: Grade 2 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Pelvic hemorrhage

description: Bleeding within the pelvic cavity.


name: Unresectable Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that is not amenable to surgical resection.


Grade 3 Leukoencephalopathy, CTCAE

description: Severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly


Enteroglucagonoma

description: An endocrine neoplasm producing glucagon.


name: Grade 2 Injury To Superior Vena Cava, CTCAE

description: Symptomatic; repair or revision not indicated


Grade 2 Ileal Ulcer, CTCAE

description: Symptomatic; altered GI function


Grade 3 Myelitis, CTCAE

description: Severe weakness or sensory loss; limiting self care ADL


Hidroacanthoma Simplex

description: A poroma characterized by the presence of aggregates of basaloid cells confined to the epidermis.


Grade 1 Restlessness, CTCAE

description: Mild symptoms; intervention not indicated


Grade 1 Laryngeal Inflammation, CTCAE

description: Mild sore throat; raspy voice


Recurrent Nevus

description: A nevus that recurs after incomplete surgical removal, biopsy, or trauma. (WHO 2018)


Venomous Animal Contact

description: Contact with a venomous animal.


name: Locally Advanced Squamous Cell Carcinoma

description: A squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 3 Fallopian Tube Perforation, CTCAE

description: Invasive intervention indicated


Grade 4 Alkalosis, CTCAE

description: Life-threatening consequences


name: Grade 4 Neck NOS Intra-Operative Injury, CTCAE


Major Congenital Anomaly

description: A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.


Carcinoma of unknown primary

description: A carcinoma which has metastasized from an unknown primary anatomic site.


Grade 2 Anal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Acute Kidney Injury, CTCAE

description: A disorder characterized by the acute loss of renal function (within 2 weeks) and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction).


name: Hematopoietic and Lymphoid Neoplasm (Antiquated)


name: Grade 3 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Blood Bicarbonate Decreased, CTCAE

description: A finding based on laboratory test results that indicate a decrease in levels of bicarbonate in a venous blood specimen.


Grade 1 Colonic Fistula, CTCAE

description: Asymptomatic


name: Adverse Event with No Consequence or Impact

description: No apparent harm occurred in relation to the adverse event.


name: Invasive Lymphoepithelioma-Like Urothelial Carcinoma

description: Invasive urothelial carcinoma with lymphoepithelioma-like features.


Clinical Chorioamnionitis

description: Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge.


name: Ventral hernia without mention of obstruction or gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, without mention of obstruction or necrosis of the herniated contents.


Lumbar meningomyelocele

description: A congenital abnormality in the lumbar region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Grade 4 Pharyngeal Hemorrhage, CTCAE

description: Life-threatening consequences; intubation or urgent intervention indicated


name: Grade 5 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Grade 3 Dysarthria, CTCAE

description: Severe impairment of articulation or slurred speech


name: Grade 4 Brachial Plexus Intra-Operative Injury, CTCAE


name: Adverse Event by CTCAE v4 Severity Grade


Autoimmune Atrophic Chronic Gastritis

description: Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.


Stage I Low-CSD Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 3 Papilledema, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


name: Grade 5 Intraoperative Head and Neck Injury, CTCAE

description: Death


name: Grade 4 Upper Airway Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Central Nervous System Hemorrhage, CTCAE


name: Grade 4 Intraoperative Gastrointestinal Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Hepatobiliary Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 4 Nails Intra-Operative Injury, CTCAE


Locally Advanced Bladder Adenocarcinoma

description: Bladder adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 3 Urinary Tract NOS Intra-Operative Injury, CTCAE


Malignant Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.


name: Grade 2 Pharynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Gallbladder Infection, CTCAE

description: A disorder characterized by an infectious process involving the gallbladder.


name: Grade 4 Persistent Pulmonary Hypertension of the Newborn, AE

description: A persistent pulmonary hypertension adverse event in a newborn characterized by life-threatening respiratory and/or hemodynamic compromise; extracorporeal membrane oxygenation (ECMO) required; oxygenation index greater than 40.


name: Grade 4 Artery NOS Intra-Operative Injury, CTCAE


Infant Leukemia

description: An acute lymphoblastic or acute myeloid leukemia that occurs in infancy.


name: Fallopian Tube Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Complication due to Medical/Surgical Care

description: An untoward event that can be attributed to care received during a medical/surgical event.


name: Ancylostomiasis due to Ancylostoma ceylonicum (disorder)

description: Infection by Ancylostoma ceylanicum.


Distal Esophagus Adenocarcinoma

description: An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus.


Grade 3 Rectal Necrosis, CTCAE

description: Tube feeding or TPN indicated; invasive intervention indicated


name: Grade 2 Peripheral Sensory Neuropathy, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE