name: Grade 4 Neonatal Coagulation Disorder, AE

description: A coagulation disorder adverse event in a newborn characterized by life threatening consequences (e.g. severe pulmonary embolism, limb ischemia, hemorrhagic shock, disseminated intravascular coagulation (DIC)); requiring urgent major care changes.


Grade 4 Cataract, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Best corrected visual acuity of 20/200 or worse in the affected eye


Fibrinogen Decreased, CTCAE

description: A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.


name: Lower Extremity Artery Intra-Operative Injury, CTCAE


name: Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Squamous cell carcinoma, small cell, nonkeratinizing

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A squamous cell carcinoma composed of small atypical cells, without morphologic evidence of keratin production.


Adipose Tissue Atrophy

description: Shrinking of adipose tissue.


name: Grade 5 Depressed Level of Consciousness, CTCAE

description: Death


Grade 5 Myocardial Infarction, CTCAE

description: Death


Grade 2 Gastrointestinal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Unresectable Biliary Tract Carcinoma

description: Biliary tract carcinoma that is not amenable to surgical resection.


Acute Myeloid Leukemia with FIP1L1-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of FIP1L1-RARA fusion protein.


Prostate Cystadenoma

description: A rare cystadenoma affecting the prostate gland. It is characterized by the presence of multilocular prostatic cysts.


Metastatic glioma

description: Glioma that has spread from its original site of growth to another anatomic site.


name: Poor Prognosis Metastatic Gestational Trophoblastic Tumor

description: Metastatic gestational trophoblastic tumor in which risk factors are present.


Hodgkin Lymphoma During Pregnancy

description: Hodgkin lymphoma that occurs during pregnancy.


name: Vaginal Adenocarcinoma of Skene Gland Origin

description: A rare vaginal adenocarcinoma arising from the Skene gland. It is characterized by morphological and immunohistochemical features similar to prostate adenocarcinoma.


Thoracic meningomyelocele

description: A congenital abnormality in the thoracic region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Adenocarcinoma of the prostate stage IV

description: Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Central Nervous System Hamartoma

description: A hamartoma that occurs in the central nervous system.


name: Grade 3 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Advanced Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Dermatitis due to unspecified substance taken internally

description: Dermatitis caused by an allergic reaction to an unspecified ingested substance.


Advanced Fibrosarcoma

description: Fibrosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 4 Bladder Stricture or Stenosis, CTCAE


Necrotic tumor

description: A neoplasm characterized by focal or diffuse tumor cell necrosis.


Dialysis Catheter Obstruction

description: Blockage of a dialysis catheter by a thrombus or other substance.


Cutaneous Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the skin.


Grade 5 Jejunal Hemorrhage, CTCAE

description: Death


Conventional Alveolar Rhabdomyosarcoma

description: An alveolar rhabdomyosarcoma characterized by the presence of large striated muscle cells with clear cytoplasm, giant cells with myoblastic differentiation, and fibrovascular septa.


Grade 3 Pharyngeal Mucositis, CTCAE

description: Severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL


name: Grade 4 Jejunum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage IIIC Fallopian Tube Cancer AJCC v7

description: Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0).  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Varicella Zoster Infection

description: An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth.


name: Grade 3 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder

description: An early post-transplant lymphoproliferative lesion characterized by plasmacytic proliferation and architectural preservation of the involved tissues.  It often regresses either spontaneously or after reduction in immunosuppression.  The immunoglobulin genes are not rearranged.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


Grade 2 Pulmonary Hypertension, CTCAE

description: Moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention


name: Hodgkin's disease nodular sclerosis stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 1 Oral Dysesthesia, CTCAE

description: Mild discomfort; not interfering with oral intake


name: Grade 4 Reproductive System and Breast Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Retroperitoneal abscess

description: An abscess that is located in the abdominal cavity posterior to the peritoneum.


Infusion Related Reaction, CTCAE

description: A disorder characterized by adverse reaction to the infusion of pharmacological or biological substances.


name: Grade 3 Gingiva Intra-Operative Injury, CTCAE


Grade 3 Otitis Media, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 2 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 3 Cheilitis, CTCAE

description: Severe symptoms; limiting self care ADL; intervention indicated


name: Dental and Teeth and Peridontal Pain, CTCAE


Confusion, Post-Ictal

description: A period of confusion following a seizure in which the patient does not respond appropriately despite appearing awake.


name: Stage II Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 1 Uterine Fistula, CTCAE

description: Asymptomatic


Hemorrhoidal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the hemorrhoids.


name: Grade 4 Lingual Nerve Intra-Operative Injury, CTCAE


name: Unresectable Transitional Cell Carcinoma

description: A transitional cell carcinoma which is not amenable to surgical resection.


name: Grade 2 Larynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Irregular Menstruation, CTCAE

description: A disorder characterized by a change in cycle or duration of menses from baseline.


Grade 1 Gynecomastia, CTCAE

description: Asymptomatic


Congenital Intrahepatic Biliary Atresia

description: A congenital disorder characterized by blockage or absence of the intrahepatic bile ducts.


name: Grade 3 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Recurrent Cytomegalovirus Infection

description: A cytomegalovirus infection that has recurred after a period of remission.


name: Grade 2 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 3 Lymphedema-Related Fibrosis, CTCAE


name: Childhood Benign Digestive System Neoplasm

description: A childhood neoplasm that arises from the digestive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Recurrent Extrapulmonary Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary neuroendocrine carcinoma after a period of remission.


Grade 4 Intestinal Stoma Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 3 Pulmonary Fibrosis, CTCAE

description: Severe hypoxia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50-75%


Grade 2 Sinus Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Unresectable Angiosarcoma

description: An angiosarcoma that is not amenable to surgical resection.


name: Reactive Epithelial Hyperplasia of the Ciliary Body

description: An increase in cell number and volume of the ciliary epithelium, usually in response to injury. (WHO 2018)


name: Grade 5 Cecum or Appendix Hemorrhage, CTCAE


Lacrimal Drainage System Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal sac or nasolacrimal duct.


name: Grade 5 Ungual Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Supraventricular Arrhythmia NOS, CTCAE


name: Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor

description: An epithelioid malignant peripheral nerve sheath tumor that does not respond to treatment.


Grade 3 Rash Maculo-Papular, CTCAE

description: Macules/papules covering >30% BSA with moderate or severe symptoms; limiting self care ADL


Hyperglycemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.


No Cardiac Valve Regurgitation

description: No evidence of any retrograde blood flow through the valve(s) in the heart. (ACC)


name: Lacrimal Drainage System Inverted Papilloma

description: A benign neoplasm of the lacrimal drainage system characterized by an inverted/endophytic or mixed growth pattern. It is the most common epithelial neoplasm of the lacrimal drainage system. (WHO 2018)


Locally Recurrent Endometrial Carcinoma

description: The reemergence of endometrial carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Grade 4 Laryngitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


description: A hepatocellular adenoma caused by activating mutations of beta-catenin.  It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis.  There is an increased risk of malignant transformation.


name: Grade 3 Periventricular Leukomalacia, AE

description: An adverse event in a newborn characterized by periventricular echodensities, evolving in to extensive cystic periventricular lesions; or densities extending in to the deep white matter.


name: Grade 3 Treatment Related Secondary Malignancy, CTCAE

description: Non life-threatening secondary malignancy


name: Ancylostomiasis due to Ancylostoma duodenale

description: Ancylostomiasis that is caused by infection by Ancylostoma Duodenale.


Grade 3 Nystagmus, CTCAE

description: Severe symptoms; limiting self care ADL


name: Grade 3 Meninges Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Grade 2 Aortic Valve Disease, CTCAE

description: Asymptomatic; moderate regurgitation or stenosis by imaging


Grade 5 Sinus Disorder, CTCAE

description: Death


name: Grade 4 Depressed Level of Consciousness, CTCAE

description: Life-threatening consequences; coma; urgent intervention indicated


name: Grade 1 Non-Malignant Pericardial Effusion, CTCAE


Grade 5 Colonic Hemorrhage, CTCAE

description: Death


Virilization, CTCAE

description: A disorder characterized by inappropriate masculinization occurring in a female or prepubertal male.


name: Grade 5 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Psychosis Including Hallucinations and Delusions, CTCAE


name: Stage IB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 3 Mitral Valve Disease, CTCAE

description: Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention


Esophageal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures).


Grade 4 Fever, CTCAE

description: >40.0 degrees C (>104.0 degrees F) for >24 hrs


name: Grade 3 Biliary Tree Right Hepatic Duct Intra-Operative Injury, CTCAE


name: Grade 1 Edema of the Head and Neck, CTCAE


name: Acute Myeloid Leukemia with RAM Immunophenotype

description: A high risk pediatric acute myeloid leukemia with an extremely poor prognosis. The blasts show bright CD56 expression, dim-to-negative expression of CD45 and CD38, and lack of HLA-DR expression. This immunophenotype was named after one of the pediatric patient's initials (RAM), from Children's Oncology Group (COG) clinical trial AAML0531.


name: Grade 4 Cranial Nerve IV Neuropathy, CTCAE


Vaginal Endometrioid Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling the endometrioid adenocarcinoma of the endometrium.


Late Disseminated Lyme Disease

description: A late stage of Lyme disease that may present in untreated patients months to years after a tick bite manifested with intermittent bouts of arthralgia, arthritis and neurologic complaints.


name: Grade 4 Cardiac Ischemia or Infarction, CTCAE


Grade 4 Pulmonary Fibrosis, CTCAE

description: Life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing


name: Grade 5 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


name: Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


name: Chest Pain in Left Third Intercostal Space

description: The location of the chest pain is within the third intercostal space on the left side.


Stage IIB Prostate Cancer AJCC v7

description: Stage IIB includes: (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T2c: Tumor involves both lobes.  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Somnolence, CTCAE

description: A disorder characterized by characterized by excessive sleepiness and drowsiness.


Dialysis Catheter Infection

description: A local or systemic infection associated with the use of a dialysis catheter.


Grade 2 Cognitive Disturbance, CTCAE

description: Moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated


name: Recurrent Pancreatic Ductal Adenocarcinoma

description: The reemergence of pancreatic ductal adenocarcinoma after a period of remission.


Vaginal Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the vagina. Representative examples include vaginal infection and vaginal fibroepithelial polyp.


name: Grade 4 Rectum Intra-Operative Injury, CTCAE


name: Grade 2 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Gastric Necrosis, CTCAE

description: Death


Grade 2 Chills, CTCAE

description: Moderate tremor of the entire body; narcotics indicated


Superficial spreading adenocarcinoma

description: An adenocarcinoma which has spread within the mucosa without further invasion of the underlying tissues.


name: Stage IV Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the biliary epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


name: Large B-cell lymphoma arising in HHV8 associated multicentric Castleman disease

description: An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive multicentric Castleman disease. It is characterized by the presence of human herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is usually seen in patients with HIV infection.


Colonic Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the colon.


Grade 2 Fat Atrophy, CTCAE

description: Covering 10-30% BSA and associated with erythema or tenderness; limiting instrumental ADL


Cyst of tonsil

description: A cystic structure in the tonsillar tissue.


Grade 1 Atrial Fibrillation, CTCAE

description: Asymptomatic, intervention not indicated


name: Verrucous carcinoma of the oral cavity stage II


Recurrent Anaplastic Ganglioglioma

description: The reemergence of anaplastic ganglioglioma after a period of remission.


Adrenoleukodystrophy, Neonatal

description: A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma.


name: Grade 2 Vulva Intra-Operative Injury, CTCAE


Cribriform comedo-type adenocarcinoma

description: An adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


name: Grade 4 Other Secondary Malignancy Possibly Related to Cancer Treatment, CTCAE


Inguinal Mass

description: An abnormal growth in the groin.


name: Pancreatic Intraductal Tubulopapillary Neoplasm

description: An epithelial neoplasm that arises from the exocrine pancreas characterized by the formation of tubular structures, high grade dysplasia, and ductal differentiation. Grossly, it is characterized by the presence of intraductal nodular masses. Morphologically, there are nodules of tubular glands and occasional papillary structures growing in dilated ducts.  There is no significant mucin production. Signs and symptoms include epigastric pain, weight loss, vomiting, steatorrhea, and diabetes mellitus.


name: Grade 2 Bronchus Intra-Operative Injury, CTCAE


description: Cancer that is not dependent upon the presence of estrogen for metastasis or growth. 2005


Maternal Obesity

description: Obesity in a female who has a child.


Hirsutism, CTCAE

description: A disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen).


name: Grade 2 Throat and Pharynx and Larynx Pain, CTCAE


Grade 5 Tracheal Stenosis, CTCAE

description: Death


Atrophy of vagina

description: A condition characterized by the absence of squamous maturation in the vaginal epithelium. It is associated with decreased estrogen production.


Genital Edema, CTCAE

description: A disorder characterized by swelling due to an excessive accumulation of fluid in the genitals.


name: Jugular Vein Intra-Operative Injury, CTCAE


Stage IIIA Cervical Cancer AJCC v8

description: Stage IIIA includes: T3a, Any N, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 2 Hypertrichosis, CTCAE

description: Increase in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact


Stage IB2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and more than 4 cm in maximum diameter. (FIGO 2009)


name: Grade 3 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


Anal Mucositis

description: An inflammatory process affecting the mucous membrane of the anus.


name: Grade 5 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 4 Glaucoma, CTCAE

description: Visual field deficit within the central 10 degrees of the visual field in the affected eye


name: Stage I Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Recurrent Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma after a period of remission.


Delayed Orgasm, CTCAE

description: A disorder characterized by sexual dysfunction characterized by a delay in climax.


name: Musculoskeletal Chest Pain due to Sternal Injury

description: A condition in which there is musculoskeletal chest pain secondary to trauma to the sternum. (ACC/AHA)


Metastatic Cutaneous Melanoma

description: A melanoma that arises from the skin and has metastasized to another anatomic site.


name: IgG-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG.


name: Recurrent Moderate-Severe Chronic Graft Versus Host Disease

description: The reemergence of moderate-severe chronic graft versus host disease after a period of remission.


Decreased Peak Drug Blood Concentration

description: Decreased maximum (peak) concentration of a drug observed after its administration.


Locally Advanced Bone Sarcoma

description: Bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Factor X Inactivation

description: Presence of inactivating antibodies to factor X in the blood.


name: Grade 3 Disseminated Intravascular Coagulation, CTCAE

description: Laboratory findings and bleeding


name: Grade 3 Small Intestinal Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 1 Radiation Excluding Chemoradiation, CTCAE


Dendritic Blue Nevus

description: A blue nevus characterized by the proliferation of dendritic melanocytes in sclerotic stromal collagen.


name: Grade 1 Alkaline Phosphatase Increased, CTCAE

description: >ULN-2.5 x ULN if baseline was normal; 2.0-2.5 x baseline if baseline was abnormal


Megaureter

description: Enlargement of the diameter of the ureter, which can be partial or complete.


name: Refractory Malignant Peripheral Nerve Sheath Tumor

description: Malignant peripheral nerve sheath tumor that is resistant to treatment.


Precordial Catch Syndrome

description: A condition in which there is musculoskeletal chest pain characterized by brief, sharp discomfort associated with inspiration. (ACC/AHA)


Seminoma, anaplastic

description: A seminoma of the testis characterized by increased cellular pleomorphism, high mitotic activity, and a non-prominent stromal lymphocytic infiltrate.


Grade 2 Telangiectasia, CTCAE

description: Telangiectasias covering >=10% BSA; associated with psychosocial impact


name: Cranial Nerve XI Intra-Operative Injury, CTCAE


Grade 3 Adrenal Insufficiency, CTCAE

description: Severe symptoms; hospitalization indicated


name: Grade 2 Serum Glutamic Pyruvic Transaminase, CTCAE


Euphoria, CTCAE 5.0

description: A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli.


NK-lymphoblastic leukemia/lymphoma

description: A precursor lymphoid neoplasm that expresses CD56 and immature T-cell markers, lacks B-lymphoid and myeloid markers, and has immunoglobulin and T-cell receptor genes in the germline configuration.


name: Grade 4 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervical Cancer by AJCC v6 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 6th edition.


name: Borderline Ovarian Serous Surface Papillary Tumor

description: A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations that contain atypical serous epithelial cells in the outer surface of the ovary.  There is no evidence of stromal invasion.


Classical Low Grade Fibromyxoid Sarcoma

description: A low grade fibromyxoid sarcoma that may have poorly formed collagen rosettes, but lacks prominent, well formed collagen rosettes.


name: Grade 2 Fallopian Tube Perforation, CTCAE

description: Invasive intervention not indicated


name: Male Non-Neoplastic Reproductive System Disorder

description: A non-neoplastic disorder that affects the male reproductive system. Representative examples include prostatitis, balanitis, and phimosis.


name: Refractory Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase

description: Polycythemia vera, post-polycythemic myelofibrosis phase that is resistant to treatment.


name: Localized Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that has focally invaded into the bladder muscularis propria.


Intestinal Stoma Leak, CTCAE

description: A finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body).


Antepartum Obstetric Thromboembolism

description: Presence of a blood clot in the maternal vascular system which originated from a distant site during the antepartum period.


name: Grade 4 Rectum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Squamous intraepithelial neoplasia grade 2


Grade 3 Penile Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 2 Vascular Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Grade 4 Myelitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Good Prognosis Metastatic Gestational Trophoblastic Tumor

description: Metastatic gestational trophoblastic tumor in which risk factors are absent.


Urothelial carcinoma urethra recurrent

description: The reemergence of urethral urothelial carcinoma after a period of remission.


Satellite Nodule

description: Additional, separate neoplastic nodules surrounding a central neoplastic lesion.


Stage 0 Testicular Cancer AJCC v8

description: Stage 0 includes: pTis, N0, M0, S0. pTis: Testicular cancer with a finding of germ cell neoplasia in situ. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


name: Localized Childhood Retinoblastoma by Toronto Guidelines v2

description: Intraocular tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Large Intestinal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine.


name: Grade 4 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Cranial Nerve VII Neuropathy, CTCAE


name: Grade 5 Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cervical meningomyelocele

description: A congenital abnormality in the cervical region of the spine in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


name: Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder

description: A monomorphic post-transplant lymphoproliferative disorder that does not respond to treatment.


Grade 1 Urine Discoloration, CTCAE

description: Present


name: Pancreatic Endocrine Glucose Intolerance, CTCAE


Grade 3 Hypocalcemia, CTCAE

description: Corrected serum calcium of <7.0-6.0 mg/dL; <1.75-1.5 mmol/L; Ionized calcium <0.9-0.8 mmol/L; hospitalization indicated


name: Serum Immunoglobulin Free Light Chain Ratio Abnormal

description: A laboratory test result indicating an abnormal kappa to lambda ratio of immunoglobulin free light chains in the serum.


name: Grade 4 Thrombotic Microangiopathy, CTCAE


name: Grade 5 Cranial Nerve I Neuropathy, CTCAE


Encephalopathy Related to COVID-19

description: Encephalopathy in a patient with probable or confirmed acute COVID-19.


name: Stage IIA Pancreatic Cancer AJCC v6 and v7

description: Stage IIA includes: T3, N0, M0.  T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 5 Adrenal Insufficiency, CTCAE

description: Death


name: Grade 2 Peripheral Nerve Infection, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


Grade 3 Neonatal Bradyarrhythmia, AE

description: A bradyarrhythmia adverse event in a newborn resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Grade 3 Neonatal Hypotension, AE

description: An adverse event in a newborn characterized by persistent hypotension affecting perfusion; requiring major care change (e.g. vaso-active drugs or hydrocortisone).


Intoxication

description: Disturbances in psychophysiological functions and responses as a result of administration or ingestion of a psychoactive substance.


name: Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Grade 2 Burn, CTCAE

description: Medical intervention; minimal debridement indicated


Grade 1 Perineal Pain, CTCAE

description: Mild pain


Non-Neoplastic Hepatobiliary Disorder

description: A non-neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples include hepatitis, cirrhosis, cholangitis, and cholecystitis.


name: Locally Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to nearby tissues or lymph nodes.


Hypophosphatemia, CTCAE

description: A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood.


Induced cataract

description: A cataract that has been produced artificially or by induction, e.g. as a result of device use, medication, trauma, tears, falls, accidental injury, etc.


Stage IA Vulvar Cancer AJCC v7

description: Stage IA includes: T1a, N0, M0. T1a: Tumor confined to the vulva and perineum, 2 cm or less in greatest dimension, and with stromal invasion no greater than 1 mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Grade 5 CNS Necrosis and Cystic Progression, CTCAE


name: Metastatic Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread to another anatomic site.


name: Recurrent Digestive System Neuroendocrine Tumor G1

description: The reemergence of digestive system neuroendocrine tumor G1 after a period of remission.


name: Atrioventricular Block First Degree, CTCAE

description: A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds.


Grade 2 Pleuritic Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 5 Bone Marrow Hypocellular, CTCAE

description: Death


Grade 3 Fetal Growth Retardation, CTCAE

description: <5% percentile of weight for gestational age


name: Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIB includes: T2, N0, M0. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Esophageal Neuroendocrine Tumor G1

description: A rare, well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The majority of cases have a polypoid appearance, are small lesions, and found incidentally.


name: Grade 3 Intraoperative Breast Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


name: Grade 4 Bronchopulmonary Hemorrhage NOS, CTCAE


Grade 4 Urethral Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Mediastinum Intra-Operative Injury, CTCAE


name: Transcription Factor-Associated Monogenic Diabetes

description: Monogenic diabetes caused by inactivating mutation(s) in transcription factors regulating expression of pancreatic beta cell genes.


name: Grade 3 Flashing Lights and Floaters in Vision, CTCAE


name: Bradyarrhythmia Related to COVID-19 Requiring Temporary or Permanent Pacing

description: Bradycardia (ventricular rate less than 60 bpm) showing signs of hypoperfusion and that requires temporary or permanent pacemaker intervention in a patient with probable or confirmed acute COVID-19.


name: Vaginal intraepithelial neoplasia grade 2

description: Vaginal intraepithelial neoplasia characterized by the presence of nuclear intraepithelial neoplastic changes in the lower two-thirds of the epithelium and parakeratosis.


Respirable Crystalline Silica Exposure

description: Environmental, occupational or consumer-based exposure to respirable particles derived from industrial processing or breakdown of silica-containing materials such as sand, concrete, stone, mortar, bricks,  glass, pottery and ceramics.


Anemia due to Increased Destruction

description: Anemia that results from an increased rate of erythrocyte destruction.


Grade 4 Fetal Growth Retardation, CTCAE

description: <1% percentile of weight for gestational age


name: Grade 4 Adrenal Gland Intra-Operative Injury, CTCAE


Grade 2 Serum Amylase Increased, CTCAE

description: >1.5-2.0 x ULN; >2.0-5.0 x ULN and asymptomatic


Grade 3 Neonatal Sinus Tachycardia, AE

description: An adverse event in a newborn characterized by persistent sinus tachycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention).


Skin squamous cell carcinoma recurrent

description: The reemergence of squamous cell carcinoma of the skin after a period of remission.


name: Grade 2 Rectal Varices Hemorrhage, CTCAE


name: Platinum-Refractory Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Grade 3 Esophageal Necrosis, CTCAE

description: Inability to aliment adequately by GI tract; invasive intervention indicated


Grade 1 Hyperparathyroidism, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 4 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Testicular Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Stage IVA Cervical Cancer FIGO 2009

description: Cervical carcinoma with rectal or bladder involvement. (FIGO 2009)


Grade 5 Methemoglobinemia, CTCAE

description: Death


name: Human Papillomavirus-Related Malignant Neoplasm

description: A malignant neoplasm associated with the presence of human papillomavirus infection.


Grade 2 Amenorrhea, CTCAE

description: Present


Metaplastic carcinoma

description: A general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation.


Foveolar-Type Adenoma

description: A rare neoplastic polyp that arises from the stomach.  It is characterized by the presence of foveolar-type epithelium.  It may be seen in patients with familial adenomatous polyposis.


Grade 4 Portal Hypertension, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 3 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Avascular joint necrosis

description: Death of bone tissue in a joint due to temporary or permanent interruption of blood flow.


Endogenous Infection

description: An infection caused by an infectious agent that is present on or in the host prior to the start of the infection.


name: Grade 3 Joint Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Unresectable Malignant Mesothelioma

description: Malignant mesothelioma that is not amenable to surgical resection.


name: Grade 5 Intraoperative Hemorrhage, CTCAE

description: Death


Classic Type Trichilemmoma

description: Trichilemmoma in which there is no evidence of sclerotic stroma formation.


name: Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Small Cell Adenocarcinoma

description: An adenocarcinoma composed of small malignant cells.


Pulmonary Edema, CTCAE

description: A disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure.


Grade 3 Productive Cough, CTCAE

description: Persistent or copious production of sputum; limiting self care ADL


Grade 1 Gait Disturbance, CTCAE

description: Mild change in gait (e.g., wide-based, limping or hobbling)


name: Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Non-Congenital Amegakaryocytosis

description: An acquired non-neoplastic disorder characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Imperforate Vagina

description: A congenital birth defect characterized by the absence of a normal vaginal opening.


name: Grade 1 Brachial Plexus Intra-Operative Injury, CTCAE


name: Grade 3 Cranial Nerve X Neuropathy, CTCAE


Hoarseness, CTCAE

description: A disorder characterized by harsh and raspy voice arising from or spreading to the larynx.


name: Stage IIIC Uterine Corpus Cancer AJCC v7

description: Stage IIIC includes: IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II. T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Puncture wound

description: Disruption of tissue caused by a pointed object.


name: Grade 4 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Central Nervous System Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the central nervous system.


name: Grade 1 Glossopharyngeal Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Recurrent Laryngeal Nerve Injuries

description: Damage to the recurrent laryngeal nerve.


Pancreatic Duct Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the pancreatic duct.


name: Hepatobiliary Disorders - Other, Specify, CTCAE


Stage I Appendix Carcinoma AJCC v8

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Kidney Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Skin Hypopigmentation, CTCAE

description: Hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact


name: Grade 1 Glomerular Filtration Rate, CTCAE


Malignant Vipoma

description: An aggressive neuroendocrine tumor located in the pancreas or small intestine. It is composed of cells containing vasoactive intestinal peptide.  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria. It displays vascular invasion and metastasizes to other anatomic sites.


Squamoid eccrine ductal carcinoma

description: A variant of ductal eccrine carcinoma with squamoid metaplasia.


name: T Acute Lymphoblastic Leukemia with Recurrent Genetic Abnormalities

description: T-acute lymphoblastic leukemias characterized by the presence of recurring cytogenetic and/or molecular abnormalities.


name: Diffuse Pediatric-Type High Grade Glioma RTK1

description: An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 1 (RTK1) alterations.


Stage IVA Vulvar Cancer AJCC v7

description: Stage IVA includes: (T1/T2, N3, M0); (T3, Any N, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Grade 2 Laryngeal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Grade 3 Aspiration, CTCAE

description: Dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally


Grade 5 Postoperative Hemorrhage, CTCAE

description: Death


name: Stenosis of Gastrointestinal Stoma, CTCAE

description: A finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body).


Grade 3 Genital Edema, CTCAE

description: Lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL


name: Grade 5 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

description: Death


Refractory Primary Myelofibrosis

description: Primary myelofibrosis that is resistant to treatment.


Cecum Ulcer, CTCAE

description: Cecum Ulcer that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure.


Congenital absence of uterus

description: A congenital abnormality characterized by the complete absence of the uterus.


name: Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease

description: Sickle cell-hemoglobin C disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


name: Dyskeratosis Congenita, Autosomal Dominant 3

description: Dyskeratosis congenita caused by autosomal dominant mutation(s) in the TINF2 gene, encoding TERF1-interacting nuclear factor 2. Mutations in TINF2 may also lead to another phenotype known as Revesz syndrome (Dyskeratosis Congenita, Autosomal Dominant 5).


Refractory Digestive System Carcinoma

description: A carcinoma hat arises from any part of the digestive system and is resistant to treatment.


Grade 4 Diarrhea, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Hematologic Neoplasm with Germline RUNX1 Mutation

description: An autosomal dominant syndrome characterized by abnormalities in platelet number and function and enhanced risk of developing myelodysplastic syndrome/acute myeloid leukemia at a young age. Patients have germline monoallelic mutations in RUNX1 gene. The clinical presentation is variable, even within the same family. Most affected individuals have a mild to moderate bleeding tendency. Platelet counts are normal or mildly reduced, with normal platelet morphology and variable degrees of platelet dysfunction. Distinct families with germline RUNX1 mutations exhibit varying risks of development of myeloid neoplasms with 11-100% (median: 44%) of family members affected. (WHO 2017)


Parietal cell carcinoma

description: An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with eosinophilic, finely granular cytoplasm.


Grade 5 Hypokalemia, CTCAE

description: Death


Ischemic Change

description: Cellular damage due to diminished oxygen supply to the tissues. The changes may be mild and associated with chronic inflammation, or severe and associated with ulceration, necrosis, and hemorrhage.


name: Grade 5 Brain and Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Duodenal Obstruction, CTCAE

description: Symptomatic; altered GI function


Excessive Bruising

description: Bruising that is disproportionately high to the amount of trauma received or reported.


Grade 5 Leukocytosis, CTCAE

description: Death


Grade 3 Device Related Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Refractory Childhood Central Nervous System Neoplasm

description: A central nervous system neoplasm in childhood that is resistant to treatment.


Pancreatobiliary-type carcinoma

description: An invasive adenocarcinoma that arises from the ampulla of Vater. It is characterized by the presence of malignant cells that resemble the malignant cells of the pancreatic ductal or extrahepatic bile duct carcinomas.


name: Bile Duct Mucinous Cystic Neoplasm, High Grade

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of severe atypia.


Grade 1 Dizziness, CTCAE

description: Mild unsteadiness or sensation of movement


name: Grade 3 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


hepatoid adenocarcinoma of gallbladder

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate that resembles hepatocellular carcinoma.


Salivary Duct Inflammation, CTCAE

description: A disorder characterized by inflammation of the salivary duct.


description: Elevated bilirubin levels in the blood of a newborn infant. It is a normal response due to the limited ability to excrete bilirubin until the maturation of the neonatal liver is complete.


name: Grade 2 Other Metabolic and Laboratory, CTCAE


name: Grade 2 Ligament Intra-Operative Injury, CTCAE


Abnormal Blood Protein

description: One or more of the blood protein levels being higher or lower than normal (e.g. Albumin, C-reactive Protein).


name: Grade 4 Paranasal Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Clinical Stage II Esophageal Adenocarcinoma AJCC v8

description: Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Ventilation or Perfusion Signs and Symptoms


name: Peritoneal Cavity Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Gastrointestinal Stoma Leak, CTCAE


Grade 2 Small Intestine Ulcer, CTCAE

description: Symptomatic; altered GI function; limiting instrumental ADL


name: Grade 3 Lower Gastrointestinal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 3 Pneumonitis and Pulmonary Infiltrates, CTCAE


name: Neuroendocrine Carcinoma of Unknown Primary

description: A neuroendocrine carcinoma that has metastasized from an  unknown primary site.


name: Preinvasive Neoplasm of the Ampullary Region

description: A premalignant neoplastic and dysplastic lesion that arises from the ampulla of Vater.  It is characterized by the absence of invasion.  This category includes intestinal-type adenomas, noninvasive papillary neoplasms of pancreatobiliary type, and flat intraepithelial neoplasia.


Anal Canal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA Esophageal Cancer AJCC v7

description: Stage IA includes: For squamous cell carcinoma: T1, N0, M0, G1, GX, Tumor location: Any. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  For adenocarcinoma: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Metastatic Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has metastasized to another anatomic site.


name: Grade 2 Catheter-Related Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Penile Pain, CTCAE

description: Severe pain; limiting self care ADL


undifferentiated carcinoma of appendix

description: A high grade carcinoma arising from the appendix, characterized by the absence of glandular or squamous differentiation.


name: Grade 5 Peripheral Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Aortic Valve Disease, CTCAE

description: Death


name: Grade 1 Cranial Nerve XI Neuropathy, CTCAE


Childhood Esophageal Carcinoma

description: A rare carcinoma of the esophagus that occurs during childhood.


name: Localized Malignant Supratentorial Neoplasm

description: A malignant supratentorial neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


name: Grade 2 Lens Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

description: Death


Grade 1 Fever, CTCAE

description: 38.0-39.0 degrees C (100.4-102.2 degrees F)


Distal Urethral Carcinoma

description: A carcinoma that arises from the distal part of the urethra.


Grade 1 Pharyngeal Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Tuberculosis of adrenal glands

description: Tuberculosis of the adrenal gland.


name: Upper Aerodigestive NOS Intra-Operative Injury, CTCAE


Grade 5 Ileus, CTCAE

description: Death


name: Grade 3 Small Bowel NOS Intra-Operative Injury, CTCAE


name: Grade 4 Right Ventricular Dysfunction, CTCAE

description: Life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated


name: Grade 4 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Testicular Sex Cord-Gonadal Stromal Tumor, Mixed Forms

description: A sex cord-stromal tumor of the testis which may contain any combination of cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms include testicular swelling and gynecomastia.


name: Lugano Classification Stage II Bulky Adult Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


name: Grade 2 CD4 Lymphocytes Decreased, CTCAE

description: <500-200/mm3; <0.5-0.2 x 10e9/L


name: Grade 5 Lower Extremity Artery Injury, CTCAE


Grade 5 Ileal Stenosis, CTCAE

description: Death


Grade 5 Enterovesical Fistula, CTCAE

description: Death


name: Digestive System Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant large cells.


Grade 3 Flu Like Symptoms, CTCAE

description: Severe symptoms; limiting self care ADL


name: Clinical Stage IV Cutaneous Melanoma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Evidence of distant metastasis. (AJCC 8th ed.)


name: Grade 2 Muscle Weakness Left-Sided, CTCAE

description: Symptomatic; evident on physical exam; limiting instrumental ADL


Gastrointestinal Carcinoid Tumor

description: A well differentiated neuroendocrine neoplasm of low grade arising from the digestive system. It is composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with small vesicular nuclei. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The tumor can occur anywhere in the digestive system; approximately 90% arise in the appendix.


Grade 4 Chylous Ascites, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Refractory Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that is resistant to treatment.


name: Small Bowel Stricture or Stenosis NOS, CTCAE


name: Stage II Adult Diffuse Mixed Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Neonatal Pneumothorax, AE

description: An adverse event in a newborn characterized by a collection of air or other gas between the visceral and parietal pleura.


name: Grade 3 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Chemical Gastritis

description: Gastritis caused by injury to the gastric mucosa by chemicals. The injury occurs due to reflux of bile and pancreatic enzymes.


name: Upper Extremity Soft Tissue Necrosis, CTCAE


Grade 1 Ileus, CTCAE

description: Asymptomatic and radiologic observations only


name: Grade 2 Middle Ear Intra-Operative Injury, CTCAE


name: Grade 2 Metabolism and Nutrition Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 4 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Nasopharynx Intra-Operative Injury, CTCAE


name: Diffuse malignant lymphoma - centroblastic-centrocytic


Stage IIB Gastric Cancer AJCC v7

description: Stage IIB includes: (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood Ependymoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood ependymoma according to the Toronto childhood cancer staging guidelines v2.


Atrophic arthritis

description: An antiquated term indicating arthritis and bone loss.


name: Grade 2 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Intraoperative Ocular Injury, CTCAE

description: Complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL


Grade 5 Neonatal Sinus Tachycardia, AE

description: A sinus tachycardia adverse event in a newborn which results in death.


name: Grade 5 Small Bowel Obstruction NOS, CTCAE


name: Grade 4 Recurrent Laryngeal Nerve Intra-Operative Injury, CTCAE


name: Grade 4 Pancreas Intra-Operative Injury, CTCAE


Grade 1 Arachnoiditis, CTCAE

description: Mild symptoms


name: Grade 4 Small Intestinal Obstruction, CTCAE


name: Grade 5 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


name: MITF Pathway-Activated Melanocytic Tumor

description: A cutaneous neoplasm associated with MITF gene rearrangement and either ACTIN-MITF translocation or MITF-CREM translocation. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis. It presents as a single non-pigmented cutaneous nodule.


Grade 3 Anal Mucositis, CTCAE

description: Severe symptoms; limiting self care ADL


small cell carcinoma of appendix

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the wall of the appendix. It is characterized by the presence of malignant small cells.


name: Adverse Event Associated with the Musculoskeletal System and Soft Tissue


Acute and chronic inflammation

description: The coexistence of a chronic inflammatory process with a superimposed polymorphonuclear neutrophilic infiltration.


name: Grade 2 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


name: Childhood Pre-B Acute Lymphoblastic Leukemia

description: Pre-B acute lymphoblastic leukemia that occurs during childhood.


Grade 4 Epistaxis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


In situ follicular neoplasia

description: A follicular neoplasia confined to the germinal centers of the lymph nodes, without evidence of disseminated disease. It is characterized by the replacement of a germinal center by neoplastic centrocytes with uniformly intense positivity for BCL2. The surrounding mantle cuff and lymphoid architecture are intact. It has a low rate of progression to follicular lymphoma, but is often associated with prior or synchronous overt lymphoma.


Benign Familial Infantile Seizures

description: A genetically heterogenous afebrile seizure disorder of infancy, typically occurring between the third and eight month of life, that is characterized by brief partial seizures occurring in clusters over a day or several days. Psychomotor and neurologic development before and after seizures are normal.


name: Grade 4 Local Complication of Device and Prosthesis, CTCAE


name: Refractory Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that is resistant to treatment.


Chronic candidiasis

description: Candidiasis that is persistent or long-standing in nature.


name: Grade 1 Retroperitoneum Hemorrhage, CTCAE


Clear cell adenocarcinoma of lung

description: A well differentiated morphologic variant of lung adenocarcinoma characterized by the predominance of clear cells.


Grade 1 Flushing, CTCAE

description: Asymptomatic; clinical or diagnostic observations only


name: Foreign Body Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Benign Germinative Follicular Epithelium Neoplasm

description: A neoplasm that arises from the germinative follicular epithelium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 3 Wrist Fracture, CTCAE

description: Limiting self care ADL; elective operative intervention indicated requiring hospitalization


name: Benign neoplasm of extrahepatic bile ducts

description: A neoplasm that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Resectable Oligodendroglioma

description: An oligodendroglioma that is amenable to surgical resection.


name: Localized Gastroesophageal Junction Adenocarcinoma

description: An adenocarcinoma that arises from the gastroesophageal junction and has not spread to other anatomic sites.


Congenital non-progressive ataxia

description: A clinically and genetically heterogenous group of rare, predominantly non-progressive neurological disorders present at birth and characterized by hypotonia, developmental delays, and ataxia. Cognitive and motor impairments may improve over time.


Cervical Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the cervix. Representative examples include endometriosis and cervicitis.


name: Malignant Lymphoma, Non-Cleaved Cell Type


Stage II Vulvar Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Carcinoma Arising in Bladder Diverticulum

description: A carcinoma arising in a bladder diverticulum. Approximately one-third to half of the cases represent non-invasive, low-grade or high-grade urothelial carcinomas. Approximately half of the invasive carcinomas are urothelial. The rest include adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.


Grade 2 Nail Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Grade 3 Blood Bilirubin Increased, CTCAE

description: >3.0-10.0 x ULN if baseline was normal; >3.0-10.0 x baseline if baseline was abnormal


Grade 5 Gallbladder Infection, CTCAE

description: Death


Grade 5 Typhlitis, CTCAE

description: Death


Grade 1 Diffuse Follicular Lymphoma

description: A follicular lymphoma with diffuse pattern characterized by the presence of 5 or less centroblasts per 40 high-power fields.


name: Stage IV Low Grade Adult Non-Hodgkin's Lymphoma


Unresectable Osteosarcoma

description: An osteosarcoma which is not amenable to surgical resection.


Device Complication

description: Any problem arising from the use of a medical device.


Infusion Site Extravasation, CTCAE

description: A disorder characterized by leakage of the infusion into the surrounding tissue. Signs and symptoms may include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site.


Grade 3 Purpura, CTCAE

description: Combined area of lesions covering >30% BSA; spontaneous bleeding


Decreased Concomitant Drug AUC

description: Decreased area under the plot of plasma concentration of a concomitant drug against time after its administration.


Giant cell and spindle cell carcinoma

description: A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle cells.


Neonatal Edema, AE

description: An adverse event in a newborn characterized by accumulation of an excessive amount of fluid in cells or intercellular tissues.


name: Grade 1 Oculomotor Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Gallbladder Benign Non-Epithelial Neoplasm

description: A non-epithelial neoplasm that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include leiomyoma, lipoma, and neurofibroma.


name: Borderline Fallopian Tube Endometrioid Tumor

description: A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells.  There is no evidence of stromal invasion.


name: Grade 1 Anal Sphincter Intra-Operative Injury, CTCAE


name: Non-T Non-B CALLA Positive Adult Acute Lymphoblastic Leukemia

description: A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in adults.


name: Pathologic Stage IIA Merkel Cell Carcinoma AJCC v8

description: Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 5 Colonic Ulcer, CTCAE

description: Death


Grade 4 Peritoneal Necrosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 2 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Salivary Gland Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Non-Neoplastic Corneal Disorder

description: A non-neoplastic disorder that affects the cornea.


name: Hodgkin's disease mixed cellularity stage I site unspecified

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Grade 2 Folliculitis, CTCAE

description: Covering 10-30% of the body surface area; topical intervention initiated


Vulvar Warty Carcinoma

description: A squamous cell carcinoma that arises from the vulva and is characterized by the presence of a warty surface and cellular changes that are caused by human papillomavirus infection.


name: Appendix Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor arising from the wall of the appendix.  It is characterized by the presence of neoplastic cells forming round solid nests and occasionally glandular structures.  The majority of the cases are asymptomatic, and they are found incidentally in appendectomy specimens.  The majority of the tumors are located in the distal end of the appendix and they are enterochromaffin-cell carcinoid tumors producing serotonin.  Most cases show morphologic evidence of appendiceal wall and lymphatic vessel invasion by tumor cells.  Despite the morphologic evidence of invasion, appendiceal carcinoid tumors only infrequently produce lymph node or distant metastases.


Solid Neoplasm

description: A benign or malignant neoplasm arising from tissues that do not include fluid areas.  Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma).  Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors.


name: Grade 3 Large Intestinal Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Laboratory Test Result

description: The outcome of a laboratory test.


name: Grade 3 Other Dermatology or Skin, CTCAE


Intimal dissection

description: A dissection of an artery that occurs though a tear in the inner lining of the blood vessel.


Grade 3 Laryngospasm, CTCAE

description: Recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage)


Advanced Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Testicular Yolk Sac Tumor, Postpubertal-Type

description: Testicular yolk sac tumor that is associated with germ cell neoplasia in situ and usually occurs as a component of mixed germ cell tumor. Pure postpubertal-type testicular yolk sac tumor is exceedingly rare.


Grade 4 Uterine Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Stenosis of Gastrointestinal Stoma, CTCAE

description: Symptomatic; IV fluids indicated <24 hrs; manual dilation at bedside


Gallbladder Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of the contents of the gallbladder.


Paratesticular Mesothelial Neoplasm

description: A mesothelial neoplasm that arises from the paratesticular structures. It includes adenomatoid tumor, well differentiated papillary mesothelial tumor, and malignant mesothelioma.


Urethra Obstruction, CTCAE

description: Blockage of the normal flow of urine in the urethra occurring following a procedure or pharmaceutical intervention.


Tissue Kallikrein Deficiency

description: A disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present.


Cutaneous Melanoma by AJCC v6 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system.


Alpha trait thalassemia

description: A condition in which a person has reduced protein production from two of the four alpha-globin alleles.


Fatigue, CTCAE 5.0

description: A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.


name: Grade 5 Peritoneal Cavity Infection with Unknown Absolute Neutrophil Count, CTCAE


Needle injury

description: A penetrating stab wound from a needle (or other sharp object) that may result in exposure to blood or other body fluids.


name: Grade 2 Lower Extremity Artery Intra-Operative Injury, CTCAE


name: Glandular Cell Intraepithelial Neoplasia


Lymphedema, CTCAE

description: A disorder characterized by excessive fluid collection in tissues that causes swelling.


Virus-Related Lymphoma

description: Lymphoma that is caused by a virus infection.


name: Grade 2 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Intraoperative Respiratory Injury, CTCAE

description: Death


Grade 1 Watering Eyes, CTCAE

description: Intervention not indicated


Grade 5 Psychosis, CTCAE

description: Death


name: Throat and Pharynx and Larynx Pain, CTCAE


Atypical hyperplasia of breast

description: A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia.


Grade 5 Rash Acneiform, CTCAE

description: Death


name: Grade 3 Spleen Intra-Operative Injury, CTCAE


name: Endocrine mucin-producing sweat gland carcinoma

description: A rare, low-grade sweat gland carcinoma with neuroendocrine differentiation. It usually arises on the eyelids and periorbital skin. It affects mostly older individuals. Women are affected more frequently than men. Morphologically, it is characterized by well-demarcated nodules with cystic, papillary, or cribriform architectural patterns. The neoplastic cells are small to intermediate polygonal to round cells. Small amounts of intracellular or extracellular mucin are present. In some cases, this carcinoma is a precursor of mucinous carcinoma.


Refractory Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that is resistant to treatment.


benign fibrous histiocytoma of bone

description: A rare, benign neoplasm usually arising from the non-metaphyseal regions of long bones or pelvis. It is characterized by the presence of fibroblastic spindle cells arranged in a whorled storiform pattern, osteoclast-like giant cells, foam cells, inflammatory cells, hemosiderin deposition and stromal hemorrhage.


name: Grade 4 Small Intestine Infection, CTCAE


name: Musculoskeletal Chest Pain due to Intercostal Myofascial Injury

description: A condition in which there is musculoskeletal chest pain secondary to trauma to the connective tissues between the ribs. (ACC/AHA)


name: Adrenal Gland Intra-Operative Injury, CTCAE


name: Grade 4 Throat and Pharynx and Larynx Pain, CTCAE


Female sexual arousal disorder

description: A disorder characterized by a recurrent or persistent inability to attain or maintain until completion of sexual activity an adequate physical response of sexual excitement, consisting of vasocongestion in the pelvis, vaginal lubrication and expansion, and swelling of the external genitalia.


name: Grade 5 Biliary Tree Stricture or Stenosis, CTCAE


Solid Alveolar Rhabdomyosarcoma

description: A morphologic variant of alveolar rhabdomyosarcoma.  It is characterized by the presence of a solid growth pattern and the absence of fibrovascular stroma.


name: Grade 3 Ventricular Arrhythmia NOS, CTCAE


Spinal Injury Related to Birth

description: An injury to the spine sustained during the birthing process.


name: Grade 2 Central Nervous System Hemorrhage, CTCAE


Stage IVB Vaginal Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Spinal Cord Infarct During Birth

description: Ischemic necrosis of the spinal cord due to spinal artery occlusion during the birthing process.


Grade 3 Thrush, CTCAE

description: IV antifungal intervention indicated


Ptosis

description: A condition in which an organ or body tissue drops or bulges out of place.


name: Grade 3 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


Metastatic Meningioma

description: A meningioma that has spread from its original site of growth to another anatomic site.


name: Grade 3 Endocrine Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Residual schizophrenia

description: A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs).


name: Brain and Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Decreased Time To Concomitant Drug Peak Blood Concentration

description: Decreased time following concomitant drug administration at which the peak drug blood concentration occurs.


Panniculitis, Peritoneal

description: A disorder characterized by chronic inflammation and fibrosis of the adipose tissues in the peritoneal cavity.


name: Stage III Ampulla of Vater Cancer AJCC v7

description: Stage III includes: T4, Any N, M0. T4: Tumor invades peripancreatic soft tissues or other adjacent organs or structures other than the pancreas.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 3 Platelet Count Decreased, CTCAE

description: <50,000-25,000/mm3; <50.0-25.0 x 10e9/L


Oral Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips.


Chemical conjunctivitis

description: Inflammation of the conjunctiva in a newborn due to chemical irritation which was acquired postnatally from iatrogenic causes.


Pancreatic Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the pancreas. The Ki-67 index is higher than 20%.


Polygenic Obesity

description: Obesity associated with variations in multiple genes.


name: Grade 3 Salivary Gland Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 4 Biliary Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Port Site Infection

description: An infection at an anatomic location used for vascular access.


Sunstroke

description: A reaction to prolonged exposure to high temperatures that can result in a failure of the body's temperature control system. It is often characterized by body temperature over 105 degrees, dehydration, headache, dizziness, nausea, vomiting, and muscle weakness.


name: Grade 2 Psychosis Including Hallucinations and Delusions, CTCAE


Acute Radiation Skin Toxicity

description: Erythema, desquamation, and other cutaneous injury resulting from, and occurring within days or weeks of, radiation exposure.


name: Stage III Appendix Neuroendocrine Tumor AJCC v7

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor directly invades other adjacent organs or structures, e.g., abdominal wall and skeletal muscle.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Delusions, CTCAE

description: A disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.


Nail Discoloration, CTCAE

description: A disorder characterized by a change in the color of the nail plate.


Chronic Myelomonocytic Leukemia-2

description: A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count.


name: Grade 3 Spermatic Cord Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 1 Partial Thromboplastin Time, CTCAE


name: Grade 4 Conjunctiva Intra-Operative Injury, CTCAE


Grade 5 Death NOS, CTCAE

description: Death


name: Grade 5 Pancreatic Anastomotic Leak, CTCAE

description: Death


Grade 4 Neonatal Diarrhea, AE

description: A diarrhea adverse event in a newborn characterized by life-threatening consequences (e.g. severe dehydration).


Birth Complication

description: The development of a problematic medical situation that occurs concurrently with the birth of a neonate.


Grade 2 Diffuse Follicular Lymphoma

description: A follicular lymphoma with diffuse pattern characterized by the presence of 6-15 centroblasts per 40 high-power fields.


Presyncope Related to COVID-19

description: Presyncope in a patient with probable or confirmed acute COVID-19.


name: Ann Arbor Stage II AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Grade 3 Thrombosis or Thrombus or Embolism, CTCAE


name: Grade 3 Bladder Intra-Operative Injury, CTCAE


Unresectable Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that is not amenable to surgical resection.


Dissociative Hysteria

description: A disorder characterized by sudden, unexpected travel away from one's home or place of work accompanied by an inability to recall one's past; the individual is confused about his or her personal identity and may assume a new identity.


Stage IIA Bone Cancer AJCC v8

description: Stage IIA includes: T1, N0, M0, G2 or G3. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


name: Grade 4 CD4 Lymphocytes Decreased, CTCAE

description: <50/mm3; <0.05 x 10e9/L


Proximal Gastric Adenocarcinoma

description: A gastric adenocarcinoma that arises from the proximal part of the stomach.


name: Grade 4 Abdomen NOS Intra-Operative Injury, CTCAE


name: Grade 4 Cranial Nerve Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Bone Marrow Hypocellular, CTCAE

description: Moderately hypocellular or >25-<50% reduction from normal cellularity for age


Fallopian Tube Cancer by AJCC v6 Stage

description: A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 6th edition.


Fistula of gallbladder

description: An abnormal communication between the gallbladder and another organ or cavity.


Aorticopulmonary Septal Defect

description: A congenital heart malformation characterised by incomplete separation of the truncus arteriosus and the aorticopulmonary trunk, resulting in communication between the aorta and pulmonary trunk.


Grade 3 Rectal Obstruction, CTCAE

description: Hospitalization indicated; invasive intervention indicated; limiting self care ADL


Grade 3 Bronchial Fistula, CTCAE

description: Invasive intervention indicated


name: Grade 2 Bronchospasm and Wheezing, CTCAE


name: Grade 1 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Grade 3 Chylous Ascites, CTCAE

description: Severe symptoms; elective operative intervention indicated


name: Grade 3 Partial Thromboplastin Time, CTCAE


Eruption cyst of jaw

description: A variant of dentigerous cyst found in the soft tissues overlying an erupting tooth. (WHO 2017)


Grade 2 Gastric Perforation, CTCAE

description: Invasive intervention not indicated


name: High Grade Gastric Intraepithelial Neoplasia

description: A gastric intraepithelial lesion characterized by the presence of neoplastic cells that are cuboidal with a high nucleus to cytoplasmic ratio, prominent nucleoli, significant architectural changes, and increased number of mitotic figures.


name: Grade 5 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Retinopathy, CTCAE

description: Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self care ADL


Localized Edema, CTCAE

description: A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site.


Grade 3 Ovarian Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 5 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Acral Edema

description: Accumulation of an excessive amount of watery fluid in cells or intercellular tissues of the hands and feet.


Early Inflammatory Arthritis

description: Early stages of inflammatory arthritis, when the underlying diagnosis is uncertain, usually little or no joint damage has occurred. Treatment may alter the disease course (e.g., potentially avert progression to full RA or other diagnosis).


name: Grade 2 Brain and Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


name: FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Acute on chronic systolic heart failure

description: Acute decompensation of chronic systolic congestive heart failure.


Diffuse Meningeal Melanocytic Neoplasm

description: A diffuse proliferation of melanocytes that affects the leptomeninges. This category includes melanocytosis and melanomatosis.


name: Adult Acute Myeloid Leukemia with Minimal Differentiation

description: An acute myeloid leukemia with minimal differentiation occurring in adults.


Bladder granuloma

description: A granuloma that develops in the urinary bladder.


Adverse Event Attributed to Research

description: An indication that an adverse event is causally related to processes a subject was exposed to during a research study.


name: Non-Neoplastic Respiratory System Disorder

description: A non-neoplastic disorder that affects the respiratory system.  Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis.


name: Metastatic Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Distant metastases present at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Grade 1 Lipohypertrophy, CTCAE

description: Asymptomatic and covering <10% BSA


name: Slipped Capital Femoral Epiphysis, CTCAE


name: Prostate Ductal Adenocarcinoma, Cribriform Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of neoplastic large back-to-back glands with slit-like lumens.


Increased Drug Half Life

description: Increased period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.


name: Grade 3 Oral Intra-Operative Injury, CTCAE


Grade 5 Diarrhea, CTCAE

description: Death


Adult Pineocytoma

description: A pineocytoma occurring in adults.


name: Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder

description: The reemergence of neoplastic post-transplant lymphoproliferative disorder after a period of remission.


name: Grade 5 Vulva Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Uterus Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Incised wound

description: A wound or cleft resulted from tissue separation into parts or laid open or penetrated with a sharp edge or instrument.


Grade 4 Gallbladder Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Hemorrhoids, CTCAE 5.0

description: A disorder characterized by the presence of dilated veins in the rectum and surrounding area.


name: Unresectable Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that is not amenable to surgical resection.


name: Unresectable Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that is not amenable to surgical resection.


Laryngeal Edema, CTCAE

description: A disorder characterized by swelling due to an excessive accumulation of fluid in the larynx.


name: Grade 2 Slipped Capital Femoral Epiphysis, CTCAE


description: An epithelioid hemangioendothelioma that is not amenable to surgical resection.


Fallopian Tube Cancer by AJCC v8 Stage

description: A term that refers to the staging of fallopian tube cancer according to the American Joint Committee on Cancer, 8th edition.


name: Grade 1 Intraoperative Hepatobiliary Injury, CTCAE

description: Primary repair of injured organ/structure indicated


Grade 5 Hallucinations, CTCAE

description: Death


name: Adenocarcinoma with spindle cell metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to spindle-shaped cells.


name: Grade 5 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Phrenic Nerve Dysfunction, CTCAE


Grade 3 Colitis, CTCAE

description: Severe abdominal pain; peritoneal signs


name: Bronchus Obstruction and Stenosis, CTCAE


name: Grade 5 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Periodontal Disease, CTCAE

description: Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss


Unresectable Cervical Carcinoma

description: Cervical carcinoma that is not amenable to surgical resection.


Grade 4 Endophthalmitis, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


name: Grade 2 Somnolence and Depressed Level of Consciousness, CTCAE


name: Small Bowel Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


name: Squamous cell carcinoma in situ with questionable stromal invasion

description: A malignant epithelial neoplasm involving all the layers of the squamous epithelium, but it is not certain if it is confined to the squamous epithelium or it has invaded the basement membrane and the underlying stroma.


Stage II Uterine Corpus Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Adverse Event Associated with Cardiac Arrhythmia


Cancer-related Cognitive Dysfunction

description: The effects of cancer and its treatments on cognitive processes.


name: Grade 5 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Gastrointestinal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 4 Biliary Tree Common Hepatic Duct Intra-Operative Injury, CTCAE


Prostate cancer stage D

description: Metastatic disease.


Polyp of esophagus

description: A benign intraluminal polypoid neoplasm of the esophagus.  It includes the squamous papilloma and the giant fibrovascular polyp.


name: Grade 4 Mucosa Infection with Unknown Absolute Neutrophil Count, CTCAE


caprolactams

A lactam in which the amide bond is contained within a seven-membered ring, which includes the amide nitrogen and the carbonyl carbon.


colchicine

An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum.


ISOXAZOLE

A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of  isoxazoles.


nutrient

A nutrient is a food component that an organism uses to survive and grow.


enzyme inhibitor

A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.


OXAZOLE

A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.


dihydroconiferyl alcohol

A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.


benzimidazole

A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings.


BENZO[D]OXAZOLE

A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.


long-chain primary fatty alcohol

A long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.


(R)-cyclopentolate

The (R)-enantiomer of cyclopentolate.


(S)-cyclopentolate

The (S)-enantiomer of cyclopentolate.


tetramine

Any polyamine that contains four amino groups.


nucleobase analogue

A molecule that can substitute for a normal nucleobase in nucleic acids.


alpha-L-fructofuranose

A L-fructofuranose with an alpha-configuration at the anomeric position.


beta-L-fructofuranose

A L-fructofuranose with a beta-configuration at the anomeric position.


L-fructofuranose

The L-enantiomer of fructofuranose.


beta-L-fructopyranose

A L-fructopyranose with a beta-configuration at the anomeric position.


L-fructopyranose

The L-enantiomer of fructopyranose.


L-cysteine thioether

Any L-cysteine derivative obtained by conversion of the thiol group into a sulfide.


zinc cation

Any zinc ion that is positively charged.


maltose

A glycosylglucose consisting of two D-glucopyranose units connected by an alpha-(1->4)-linkage.


lactose

A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.


D-glucose

A glucopyranose having D-configuration.


A glucose with D-configuration.


quinone

Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).