Grade 2 Duodenal Infection, CTCAE

description: Moderate symptoms; medical intervention indicated (e.g., oral antibiotics)


name: Primary CD30-Positive T-Cell Lymphoproliferative Disorder

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A spectrum of T-cell lymphoproliferative disorders that arise from skin, subcutaneous tissue, and head and neck mucosal sites. They are characterized by the presence of CD30-positive neoplastic lymphocytes. Cells that resemble the hallmark cells of anaplastic large cell lymphoma are often seen.


name: Grade 3 Respiratory Tract Hemorrhage NOS, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Grade 4 Ligament Intra-Operative Injury, CTCAE


name: Grade 2 Lens Intra-Operative Injury, CTCAE


Vaginal Warty Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


name: Infection of peritoneal dialysis catheter

description: A local or systemic infection associated with the use of a peritoneal dialysis catheter.


name: Grade 2 Spermatic Cord Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


Stage I Bone Cancer AJCC v8

description: Stage I includes: IA: (T1, N0, M0, G1 or GX); IB: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T1: Tumor measuring 8 cm or less in greatest dimension. T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Grade 2 Stoma Site Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Human Papillomavirus-Independent Cervical Squamous Cell Carcinoma

description: A cervical squamous cell carcinoma not associated with human papillomavirus infection.


Grade 4 Corneal Ulcer, CTCAE

description: Perforation in the affected eye


name: p53-Mutant Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the presence of p53 gene mutations.


Tracheal web

description: A rare congenital or acquired abnormality characterized by the presence of a web-like thin layer of tissue that narrows the lumen of the trachea. It may result in wheezing, dyspnea, and respiratory failure.


Grade 1 Anxiety, CTCAE

description: Mild symptoms; intervention not indicated


Grade 1 Folliculitis, CTCAE

description: Covering <10% of the body surface area; no intervention indicated


name: Childhood Pancreatic Acinar Cell Carcinoma

description: An acinar cell carcinoma that arises from the pancreas during childhood.


Gastric hyperplastic polyp

description: A non-neoplastic polyp that arises from the stomach and is characterized by the presence of dilated gastric foveoli, edematous changes, and inflammation.


name: Grade 1 Carotid Artery Intra-Operative Injury, CTCAE


Metastatic Nested Urothelial Carcinoma

description: Nested urothelial carcinoma that has spread to another anatomic site.


Extrapulmonary Small Cell Carcinoma

description: A small cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


name: Refractory Male Reproductive System Carcinoma

description: Male reproductive system carcinoma that is resistant to treatment.


Proliferative Inflammatory Atrophy

description: A lesion in the prostate gland characterized by glandular atrophy, chronic inflammation, and epithelial hyperplasia. It has been suggested that it is a precancerous lesion and it may lead to the development of prostatic intraepithelial neoplasia and prostatic carcinoma.


External hemorrhoids (disorder)

description: A hemorrhoid which originates below the dentate line.


Stage III Vulvar Cancer AJCC v7

description: Stage III includes: IIIA: (T1/T2, N1a/N1b, M0); IIIB: (T1/T2, N2a/N2b, M0); IIIC: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Gastroesophageal Junction Adenocarcinoma

description: The reemergence of gastroesophageal junction adenocarcinoma after a period of remission.


Grade 4 Ventricular Tachycardia, CTCAE

description: Life-threatening consequences; hemodynamic compromise


Hindgut Neuroendocrine Tumor G1

description: A neuroendocrine tumor grade 1 that arises from the sigmoid colon, descending colon, or rectum.


silent stroke

description: An asymptomatic cerebral infarction that was incidentally noted by T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensities on an MRI of the brain.


Feeding Intolerance, AE

description: An adverse event in a newborn characterized by inability to achieve a full feeding volume.


name: Refractory Acute Myelomonocytic Leukemia

description: Acute myelomonocytic leukemia that does not respond to treatment.


name: Grade 3 Thrombosis or Embolism Vascular Access Related, CTCAE


Grade 3 GGT Increased, CTCAE

description: >5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Postpartum Obstetric Septic Embolism

description: Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the postpartum period.


Disabling Adverse Event

description: An adverse event, and/or its immediate sequelae which is associated with physical or mental disabilities that affect or limit the ability of a person to perform activities of daily living (eating, ambulation, toileting, etc.).


name: Human Papillomavirus-Related Verrucous Carcinoma

description: A verrucous carcinoma that is associated with human papillomavirus infection.


name: Stage IV Acral Lentiginous Melanoma AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Decreased CYBB Expression

description: An indication that the expression of CYBB is lower than the normal range of values.


Neonatal Adverse Event

description: Findings suggesting an adverse event in a neonate or newborn.


name: Grade 3 Cardiac Troponin I Increased, CTCAE

description: Levels consistent with myocardial infarction as defined by the manufacturer


mCode Neoplastic Disease/Finding

description: Terminology related to neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Uterine Corpus Cancer by AJCC v6 Stage

description: A term that refers to the staging of uterine corpus cancer according to the American Joint Committee on Cancer, 6th edition.


name: Grade 2 Oral Intra-Operative Injury, CTCAE


name: Non-Metastatic Gestational Trophoblastic Tumor

description: Gestational trophoblastic tumor that is confined to the site in which it initially manifested.


Injury of phrenic nerve

description: Damage to the phrenic nerve.


Non-Neoplastic Endocrine Disorder

description: A non-neoplastic disorder that affects the endocrine system.  Representative examples include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency.


name: Grade 1 Otitis Middle Ear Non Infectious, CTCAE


Uterine Corpus Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the uterine corpus. Representative examples include endometritis and uterine adenomyosis.


name: Bone Tumor of Undefined Neoplastic Nature

description: A group of lesions that affect the bone and have the appearance and cytogenetic or molecular characteristics of neoplasms but the clinical behavior is suggestive of a non-neoplastic process.


Unresectable Neuroendocrine Tumor G1

description: Neuroendocrine tumor grade 1 that is not amenable to surgical resection.


name: Metastatic Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that has spread from its original site of growth to another anatomic site.


name: Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder

description: A CD30-positive T-cell lymphoproliferative disorder that arises from the skin and is characterized by overlapping morphological features between anaplastic large cell lymphoma and lymphomatoid papulosis.


Late Effects Severity Grade

description: A severity grade assigned to the late effects.


Grade 3 Ataxia, CTCAE

description: Severe symptoms; limiting self care ADL; mechanical assistance indicated


name: Grade 4 Pancreas Exocrine Enzyme Deficiency, CTCAE


Pelvic Floor Muscle Weakness, CTCAE

description: A disorder characterized by a reduction in the strength of the muscles of the pelvic floor.


name: Childhood Acute Promyelocytic Leukemia with PML-RARA

description: An acute promyelocytic leukemia with PML-RARA fusion occurring in children.


Grade 2 Scalp Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 3 Neonatal Hypertension, AE

description: An adverse event in a newborn characterized by persistent or recurrent hypertension, with systolic or diastolic blood pressure above the 99th percentile; need for antihypertensive medication.


Grade 5 Wound Dehiscence, CTCAE

description: Death


Metastatic osteosarcoma

description: An osteosarcoma which has spread to another anatomical site.


Stage IB Cutaneous Melanoma AJCC v7

description: Stage IB includes: (T1b, N0, M0); (T2a, N0, M0).  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Tissue or Organ Disruption

description: A loss of structural integrity within a tissue or organ.


name: Grade 3 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


Recurrent Childhood Hodgkin Lymphoma

description: The reemergence of Hodgkin lymphoma after a period of remission during childhood.


name: Grade 2 Cerebral Artery Intra-Operative Injury, CTCAE


Refractory Severe Aplastic Anemia

description: Severe aplastic anemia that is resistant to treatment.


name: Anal Sphincter Intra-Operative Injury, CTCAE


name: Stage IIIA Fallopian Tube Cancer AJCC v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis outside the pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Grade 3 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Pancreatic Intraductal Tubulopapillary Neoplasm with an Associated Invasive Carcinoma

description: A pancreatic intraductal tubulopapillary neoplasm characterized by the presence of an invasive carcinomatous component.  The invasive carcinoma has a tubular pattern.


Grade 5 Breast Infection, CTCAE

description: Death


Non-Infectious Gastroenterocolitis

description: An inflammatory disease of the stomach and intestines due to a non-infectious cause.


Iris vascular disorder

description: A vascular disorder or the iris.


name: Smooth Muscle Tumor of Uncertain Malignant Potential

description: A neoplasm with smooth muscle differentiation that cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings. The vast majority of cases arise from the female reproductive system. Malignant behavior has been reported in a minority of cases.


Adult Intracranial Meningioma

description: An intracranial meningioma that occurs during adulthood.


Grade 3 Pancreatic Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 2 Epstein-Barr Virus Infection Reactivation, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Vascular Disorder

description: A term that includes all non-neoplastic vascular disorders.


Grade 1 Wound Complication, CTCAE

description: Observation only; topical intervention indicated


mCode Disease/Finding

description: Terminology related to diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Grade 5 Rectal Mucositis, CTCAE

description: Death


Stage III Childhood Large Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


name: Postneoadjuvant Therapy Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Pancreatic Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of exocrine and endocrine pancreatic cancer including well-differentiated neuroendocrine tumors according to the American Joint Committee on Cancer, 6th and 7th editions.


Recurrent Childhood Ependymoma

description: The reemergence of ependymoma in childhood after a period of remission.


Childhood Osteoblastoma

description: An osteoblastoma that occurs during childhood.


name: Grade 5 Reproductive System and Breast Disorders - Other, Specify, CTCAE

description: Death


name: Vein Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Angiosarcoma

description: Angiosarcoma that is resistant to treatment.


name: Grade 4 Cranial Nerve II Neuropathy, CTCAE


Grade 2 Myocarditis, CTCAE

description: Symptoms with moderate activity or exertion


Grade 5 Sleep Apnea, CTCAE

description: Death


Cardiac Mesenchymal Hamartoma

description: A benign soft tissue mass that involves the endocardium, myocardium, or epicardium. It is characterized by the presence of an admixture of mature mesenchymal tissues normally found within the heart.


name: Grade 2 Mediastinum Intra-Operative Injury, CTCAE


Resectable Malignant Bone Neoplasm

description: Malignant bone neoplasm that is amenable to surgical resection.


Grade 3 Fungemia, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Grade 2 Floaters, CTCAE

description: Limiting instrumental ADL


Stage IA Gastric Carcinoma

description: Stage IA includes: T1, N0, M0.  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 1 Keratitis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 1 Conduction Disorder, CTCAE

description: Mild symptoms; intervention not indicated


Vasovagal Reaction, CTCAE

description: A disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve.


name: Hemoglobin Increase Greater than or Equal to 1.0 g/dL

description: A semiquantitative finding indicating that the concentration of hemoglobin has increased by at least 1.0 g/dL compared to the value recorded for a previous sample from that subject.


Biliary Adenofibroma

description: A rare benign neoplasm that arises from the intrahepatic bile ducts.  It is characterized by the presence of biliary epithelial tissue and fibroblastic stroma.


name: Grade 2 Gastrointestinal Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 1 Nose Intra-Operative Injury, CTCAE


name: Recurrent Acute Leukemia of Ambiguous Lineage

description: The reemergence of acute leukemia of ambiguous lineage after a period of remission.


name: Metastatic Intracranial Malignant Neoplasm

description: An intracranial malignant neoplasm that has spread from its original site of growth to another anatomic site.


name: Adverse Event Attribution to Product or Procedure

description: A specific identifiable level (defined qualitatively or quantitatively) of probability of adverse event being caused or associated with the product or procedure administration to a patient.


Distantly Metastatic Malignant Neoplasm

description: A malignant tumor that has spread from its original (primary) site of growth to another site distant from the primary site.


name: Grade 2 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Iatrogenic Obesity

description: Obesity resulting from medical treatment or intervention.


Immunosuppressive Disorder

description: A disorder in which immune function is suppressed.


Rare Childhood Malignant Neoplasm

description: An infrequent malignant neoplasm that occurs during childhood.


Advanced Biliary Tract Carcinoma

description: Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread extensively to other anatomic sites or is no longer responding to treatment.


FNCLCC Sarcoma Grade 2

description: A sarcoma with a total score of 4 or 5 according to the FNCLCC guidelines.


Gynecomastia, CTCAE 5.0

description: A disorder characterized by excessive development of the breasts in males.


Thyroid-Binding Globulin Deficiency

description: Subnormal concentration of thyroid-binding globulin.


name: Malignant melanoma in precancerous melanosis

description: A melanoma arising from an atypical intraepithelial melanocytic hyperplasia.


name: Grade 3 Urinary Tract Obstruction, CTCAE

description: Altered organ function (e.g., hydronephrosis or renal dysfunction); invasive intervention indicated


Stage I Esophageal Cancer AJCC v7

description: Stage I includes: For squamous cell carcinoma: IA (T1, N0, M0, G1, GX, Tumor location: Any); IB (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X).  For adenocarcinoma: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


name: Skin Squamous Cell Carcinoma with Osteoclast-Like Giant Cells

description: A rare squamous cell carcinoma of the skin characterized by the presence of multinucleated non-neoplastic giant cells that resemble osteoclasts.


Grade 1 Chills, CTCAE

description: Mild sensation of cold; shivering; chattering of teeth


Grade 1 Hematoma, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 2 Anus Stricture or Stenosis, CTCAE


Job Strain

description: Negative physical or emotional health outcomes resulting from high job demands with low job decision latitude.


Stage IA Uterine Corpus Cancer AJCC v7

description: Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Grade 1 Cardiac Ischemia or Infarction, CTCAE


Grade 5 Atrial Fibrillation, CTCAE

description: Death


name: Grade 5 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Methemoglobinemia, CTCAE

description: Requiring urgent intervention


Tooth Development Disorder, CTCAE

description: A disorder characterized by a pathological process of the teeth occurring during tooth development.


name: Hodgkin's disease mixed cellularity stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Cronkhite-Canada syndrome

description: Non-neoplastic polyps that arise from the stomach and are often indistinguishable from hyperplastic polyps.  They may be associated with the presence of polyps in other parts of the gastrointestinal tract.  Associated clinical signs and symptoms are nail atrophy, alopecia, and hyperpigmentation.


Grade 3 Syncope, CTCAE

description: Fainting; orthostatic collapse


name: Other Pulmonary and Upper Respiratory, CTCAE


Grade 2 Pulmonary Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Grade 5 Venous Injury, CTCAE

description: Death


Early Rheumatoid Arthritis

description: Recent diagnosis of rheumatoid arthritis (usually within one to two years of onset) during which treatment may be more effective and possibly improve the disease course.


name: Lip or Perioral Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Genitourinary Stoma Hemorrhage, CTCAE


Grade 5 Colonic Stenosis, CTCAE

description: Death


Conjunctival Balloon Cell Nevus

description: A balloon cell nevus that arises from the conjunctiva.


name: Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 1 Ischemia Cerebrovascular, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Appendix Intra-Operative Injury, CTCAE


Grade 4 Duodenal Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Astler-Coller A Rectal Carcinoma

description: Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.)


name: Grade 4 Cranial Nerve II Intra-Operative Injury, CTCAE


name: Grade 5 Pleura Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Atrioventricular Block Complete, CTCAE

description: Non-urgent intervention indicated


name: Grade 3 Small Bowel Obstruction NOS, CTCAE


Condyloma acuminata of cervix

description: A benign neoplasm that arises from the cervix. It is associated with human papillomavirus infection and is characterized by the presence of papillary structures with fibrovascular cores. The papillary structures are covered with stratified squamous epithelium. Koilocytosis is usually present.


name: Grade 5 Cardiac Ischemia or Infarction, CTCAE


name: Locally Advanced Urethral Urothelial Carcinoma

description: A urethral urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 1 Constipation, CTCAE

description: Occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema


Stage I Bone Sarcoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Grade 3 Watering Eyes, CTCAE

description: Marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


Grade 1 Venous Injury, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Bacterial prostatitis

description: An acute or chronic bacterial infection that affects the prostate gland.


name: Grade 5 Meninges Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Biliary Tree Stricture or Stenosis, CTCAE


name: Grade 3 Ligament Intra-Operative Injury, CTCAE


name: Grade 4 Catheter-Related Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Stage IIIA2 Fallopian Tube Cancer AJCC v8

description: Stage IIIA2 includes: T3a, N0/N1, M0. T3a: T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Generalized morphea

description: A type of morphea characterized by four or more plaques found in two or more anatomic locations. The plaques are indurated, generally well-delineated, and may include muscle atrophy in affected areas; there is no visceral involvement.


name: Grade 2 Cranial Nerve V Motor Intra-Operative Injury, CTCAE


name: Grade 5 Colon or Cecum or Appendix Necrosis, CTCAE


Grade 3 Agitation, CTCAE

description: Severe agitation; hospitalization not indicated


name: Grade 4 Metabolic or Respiratory Alkalosis, CTCAE


name: Grade 4 Thyroid Intra-Operative Injury, CTCAE


Vinyl Chloride or Derivatives Exposure

description: Environmental, occupational, or consumer-based exposure to vinyl chloride or its derivatives during the manufacture or breakdown of polyvinyl chloride (PVC) and other vinyl containing products.


name: Congenital, Familial and Genetic Disorders, CTCAE


name: Grade 2 Urethra Intra-Operative Injury, CTCAE


name: Grade 3 Postoperative Thoracic Procedure Complication, CTCAE

description: Extubated >72 hrs postoperatively, but before tracheostomy indicated


Pathological dislocation of joint

description: A joint dislocation not due to trauma.


Grade 2 Esophageal Ulcer, CTCAE

description: Symptomatic; altered GI function; limiting instrumental ADL


Libido Decreased, CTCAE

description: A disorder characterized by a decrease in sexual desire.


Grade 3 Pulmonary Fistula, CTCAE

description: Invasive intervention indicated


name: T-Cell Proliferation of Uncertain Malignant Potential

description: A T-cell lymphoproliferative disorder with uncertain malignant potential. A representative example is lymphomatoid papulosis.


Grade 2 Injury To Carotid Artery, CTCAE

description: Repair or revision not indicated


name: Grade 1 Neuroendocrine Growth Hormone Secretion Abnormality, CTCAE


Sclerosing peritonitis

description: A rare peritoneal cavity disorder that is characterized by the development of dense fibrous tissue in the peritoneum and the creation of severe adhesions in the abdomen that result in partial or complete small bowel obstruction. It may be idiopathic or develop in patients who receive peritoneal dialysis treatment. Patients present with abdominal distention and pain.


Grade 2 Lymphocele, CTCAE

description: Symptomatic; medical intervention indicated


COVID-19 Rash

description: A change in the appearance or texture of the skin that is associated with SARS-CoV-2 infection (COVID-19).


name: Grade 5 Uterus Stricture or Stenosis, CTCAE


name: Grade 2 Vas Deferens Anastomotic Leak, CTCAE


Ocular Foreign Body

description: External material that enters the eye.


Dermal Duct Tumor

description: A poroma characterized by the presence of small nodules of neoplastic cells in the superficial dermis without connection to the epidermis.


B-Cell Lymphoproliferative Disorder

description: A non-neoplastic or neoplastic proliferation of B-lymphocytes.


Gallbladder Cancer by AJCC v6 Stage

description: A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 6th edition.


Stage IV Gallbladder Cancer AJCC v7

description: Stage IV includes: IVA (T4, N0-1, M0); IVB (Any T, N2, M0); (Any T, Any N, M1).  T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


Monogenic Obesity

description: Obesity associated with an identifiable mutation in a single gene.


Fibrocartilaginous mesenchymoma

description: A very rare, locally aggressive neoplasm arising from the bones, usually from the metaphysis of long tubular bones. It is composed of spindle cells, hyaline cartilage nodules, and trabeculae of bone. It may recur locally, but no metastases have been reported.


Stage II Cervical Cancer FIGO 2009

description: Cervical carcinoma invading beyond the uterus but not extending onto the lower third of the vagina or to the pelvic wall. (FIGO 2009)


name: Grade 2 Rectum Intra-Operative Injury, CTCAE


name: Metastatic Midgut Neuroendocrine Tumor G2

description: A midgut neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


name: Grade 4 Pharynx Obstruction and Stenosis, CTCAE


name: Chest Pain Along Right Midclavicular Line

description: The location of the chest pain is along the right midclavicular line.


Grade 1 Pruritus, CTCAE

description: Mild or localized; topical intervention indicated


name: Human Papillomavirus-Independent Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma not associated with human papillomavirus infection.


name: Grade 3 Psychosis Including Hallucinations and Delusions, CTCAE


Grade 2 Esophageal Stenosis, CTCAE

description: Symptomatic; altered GI function


Stage III Gastric Cancer AJCC v6

description: Stage III includes: IIIA (T2a/b, N2, M0); (T3, N1, M0); (T4, N0, M0).  IIIB: (T3, N2, M0).  N0: No regional lymph node metastasis. N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes. T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa. T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. T4: Tumor invades adjacent structures.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 2 Penile Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Refractory Anal Carcinoma

description: Anal carcinoma that does not respond to treatment.


Nasal Congestion, CTCAE

description: A disorder characterized by obstruction of the nasal passage due to mucosal edema.


name: Refractory Malignant Female Reproductive System Neoplasm

description: Malignant female reproductive system neoplasm that is resistant to treatment.


name: Pharynx Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Anal Fistula, CTCAE

description: Asymptomatic


name: Grade 5 Ureter Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage II Gallbladder Cancer AJCC v8

description: Stage II includes: IIA: T2a, N0, M0; IIB: T2b, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Abdomen NOS Intra-Operative Injury, CTCAE


name: Ampullary Noninvasive Papillary Neoplasm, Pancreatobiliary Type

description: An exophytic, preinvasive, papillary epithelial neoplasm that arises from the ampulla of Vater.  Histologically it resembles the papillary neoplasms of the biliary tree.  This category includes neoplasms with low grade dysplasia and high grade dysplasia.


name: Grade 1 Nervous System Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Mucosa Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Lung Thoracic Nerve Intra-Operative Injury, CTCAE


Stage IVA Uterine Corpus Cancer AJCC v7

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Somnolence and Depressed Level of Consciousness, CTCAE


Drug Resistant Bacterial Infection

description: A bacterial infection that is resistant to antibiotics and antimicrobials.


name: Metastatic Pancreatic Neuroendocrine Carcinoma

description: Pancreatic neuroendocrine carcinoma that has spread from the original site of growth to another anatomic site.


Infective Phlebitis

description: Infection at the site of needle puncture or intravenous catheter placement due to poor aseptic techniques. It is characterized by erythema, pain, swelling, and induration at the catheter insertion site.


Grade 3 Premature Delivery, CTCAE

description: Delivery of a liveborn infant at 24 to 28 weeks gestation


name: Grade 3 Cranial Nerve V Sensory Intra-Operative Injury, CTCAE


Bacterial tracheitis

description: Bacterial infectious process with formation of mucopurulent membranes affecting the trachea. Causative agents include Staphylococcus, Streptococcus, Haemophilus influenzae, Pseudomonas, and Klebsiella.


name: Grade 5 Vas Deferens Stricture or Stenosis, CTCAE


Urinary Retention, CTCAE

description: A disorder characterized by accumulation of urine within the bladder because of the inability to urinate.


Nystagmus, CTCAE 5.0

description: A disorder characterized by involuntary movements of the eyeballs.


name: Grade 3 Bone Intra-Operative Injury, CTCAE


name: Intermediate Grade Adult Non-Hodgkin's Lymphoma


Grade 1 Postnasal Drip, CTCAE

description: Mild symptoms; intervention not indicated


Grade 2 Hemoglobin Increased, CTCAE

description: Increase in >2-4 g/dL


Pre-Existing Organ Dysfunction

description: Organ dysfunction that was present prior to evaluation.


Atypical Endometriosis

description: A precancerous lesion characterized by the presence of atypical glandular epithelial features in foci of endometriosis. Atypical endometriosis has been observed in contiguity with carcinomas.


Grade 4 Ileal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Stage III Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading adjacent organs (stomach, spleen, colon, adrenal gland) or the wall of large vessels (celiac axis or the superior mesenteric artery). N0: No regional lymph node involvement. N1: Regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 3 Spleen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IV Low-CSD Melanoma AJCC v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


Grade 2 Vagus Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 5 Radiculitis, CTCAE

description: Death


name: Microsatellite Stable Endometrial Carcinoma

description: Endometrial carcinoma characterized by the absence of microsatellite instability.


name: Human Papillomavirus-Related Vulvar Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vulva and is caused by human papillomavirus infection.


Non-Neoplastic Eyelid Disorder

description: A non-neoplastic disorder that affects the eyelid.


carcinoma of lacrimal apparatus

description: A carcinoma that arises from the lacrimal gland or the lacrimal drainage system.


Grade 2 Gastric Stenosis, CTCAE

description: Symptomatic; altered GI function


name: Acute Myocardial Injury with Right Ventricular Dysfunction Related to COVID-19

description: Acute myocardial injury with evidence of newly reduced right ventricular function in a patient with probable or confirmed acute COVID-19.


name: Prostate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

description: A prostate adenocarcinoma characterized by the presence of cells with eosinophilic cytoplasmic granules that are positive for neuroendocrine markers by immunohistochemistry.


Grade 1 Urinary Incontinence, CTCAE

description: Occasional (e.g., with coughing, sneezing, etc.), pads not indicated


Mediastinal Cyst

description: A fluid-filled, epithelium-lined cyst located in the mediastinum.


name: Grade 4 Blood and Lymphatic System Disorders - Other, Specify, CTCAE


Increased Peak Drug Blood Concentration

description: Increased maximum (peak) concentration of a drug observed after its administration.


Stage IV Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Grade 4 Peripheral Sensory Nerve NOS Intra-Operative Injury, CTCAE


Osteolytic Neoplasm

description: A neoplasm that involves bone destruction.


name: Clinical Stage IB Cutaneous Melanoma AJCC v8

description: Stage IB includes: (T1b, N0, M0); (T2a, N0, M0). T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Recurrent Malignant Neoplasm

description: The reemergence of a malignant neoplasm after a period of remission.


name: Childhood Low Grade Myofibroblastic Sarcoma

description: A low-grade myofibroblastic sarcoma that occurs during childhood.


Umbilical Vasculitis

description: A neutrophilic infiltrate arising from fetal vessels of the umbilical cord into the umbilical vessel wall and oriented towards the amniotic cavity.


name: Grade 3 Nose Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Deficiency of sulfatase

description: An inherited, progressive neurodegenerative disorder caused by the lack of functional sulfatase leading to the accumulation and deposition of glycosaminoglycans in tissue.


name: Unresectable Paratesticular Malignant Mesothelioma

description: Paratesticular malignant mesothelioma that is not amenable to surgical resection.


Dialysis Catheter Exit Site Infection

description: Local infection at the dialysis catheter exit site.


Giant Cell Epulis

description: A reactive localized proliferation of mononuclear cells and osteoclast-type giant cells in a vascular stroma outside bone. It occurs in the gingiva or alveolar mucosa. (WHO 2017)


Central Nervous System Carcinoma

description: A malignant tumor arising in the epithelial cells of the brain or spinal cord.


name: Plasma Cell Neoplasm with Associated Paraneoplastic Syndrome

description: A term that refers to rare paraneoplastic syndromes associated with plasma cell neoplasms. This category includes the following: POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes); TEMPI syndrome (telangiectasia, elevated erythropoietin and erythrocytosis, monoclonal gammopathy, perinephric fluid collection, and intrapulmonary shunting); and AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma).


name: Grade 3 Associated with Dentures or Dental Prosthesis, CTCAE


Vaginal cancer recurrent

description: The reemergence of vaginal carcinoma after a period of remission.


signet ring cell carcinoma of appendix

description: An adenocarcinoma arising from the appendix, characterized by the presence of signet-ring, mucin-producing malignant cells.  The signet-ring cells constitute more than fifty-percent of the malignant cells.


Refractory Acute Biphenotypic Leukemia

description: Acute biphenotypic leukemia that is resistant to treatment.


name: Grade 5 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Otitis Media, CTCAE

description: Death


name: Grade 2 Cranial Nerve III Intra-Operative Injury, CTCAE


name: Grade 2 Herpes Simplex Reactivation, CTCAE

description: Moderate symptoms; medical intervention indicated


Genital Tract Fistula

description: An abnormal communication between the genital tract and another organ or anatomic structure.


name: Grade 2 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


name: Grade 1 Psychiatric Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Localized Childhood Ependymoma by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 5 Fallopian Tube Stricture or Stenosis, CTCAE


Recurrent Primary Myelofibrosis

description: The reemergence of primary myelofibrosis after a period of remission.


Grade 3 Prostatic Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Left Ventricular Systolic Dysfunction, CTCAE 3.0

description: Defined in terms of ejection fraction, a good clinical indicator of ventricular systolic function. Normal ejection fraction is 0.50 or more (>50%). Left ventricular systolic dysfunction is generally defined as an ejection fraction equal to or less than 0.40 (<40%).


name: Grade 2 Larynx Intra-Operative Injury, CTCAE


name: Borderline Fallopian Tube Mucinous Tumor

description: A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion.


Grade 4 Apnea, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Mucous Membrane Hemangioma

description: A hemangioma arising from the mucous membranes.


Grade 2 Retinal Tear, CTCAE

description: No retinal detachment and treatment indicated


name: Grade 1 Cranial Nerve VII Motor Intra-Operative Injury, CTCAE


Aortic Valve Disease, CTCAE

description: A disorder characterized by a defect in aortic valve function or structure.


name: Grade 4 Serum Hypertriglyceridemia, CTCAE


Adenocarcinoma with apocrine metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to cells with abundant, usually granular eosinophilic cytoplasm.


Gastroesophageal Reflux Disease, CTCAE

description: A disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion.


name: Stage IB Esophageal Adenocarcinoma AJCC v7

description: Stage IB includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Grade 4 Epstein-Barr Virus Infection Reactivation, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Phantom Pain Associated with Missing Limb, CTCAE


Grade 3 Injury To Jugular Vein, CTCAE

description: Symptomatic limiting self care ADL; repair or revision indicated


name: Grade 3 Cranial Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Paraganglioma

description: A paraganglioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Grade 5 Constipation, CTCAE

description: Death


name: Grade 5 Retroperitoneum Hemorrhage, CTCAE


name: Grade 5 Duodenum Stricture or Stenosis, CTCAE


Thymic Damage

description: Anatomic injury or physiologic dysfunction of the thymus gland.


Hyperactive Chest Appearance

description: Inspection of the region of the anterior surface of the chest and epigastrium reveals a highly or excessively active or hyperkinetic apical impulse.


name: Childhood Solid Pseudopapillary Neoplasm of the Pancreas

description: A solid pseudopapillary neoplasm of the pancreas occurring during childhood. It is the most frequent pediatric pancreatic tumor. It usually affects adolescent females.


name: Early Stage Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that has not spread beyond the pancreas.


Enzyme Deficiency

description: A finding in which there is a subnormal amount of an enzyme. Enzymes are proteins that are necessary in certain catabolic processes.


Recurrent Primary Malignant Neoplasm

description: The reemergence of a primary malignant neoplasm after a period of remission.


name: Grade 4 Retroperitoneum Hemorrhage, CTCAE


Chest Pain in Upper Sternum

description: The location of the chest pain is in the upper portion of the sternum.


name: Grade 3 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Gingival Pain, CTCAE

description: Mild pain


regressing melanoma of skin

description: Cutaneous melanoma characterized by the disappearance of the melanoma cells from the primary tumor.


name: Grade 2 Prostate Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Refractory Metastatic Digestive System Carcinoma

description: A digestive system carcinoma that has metastasized to another anatomic site and is resistant to treatment.


Lymphoepithelial tumor of skin

description: A rare, poorly differentiated squamous cell carcinoma of the skin. It is characterized by the presence of tumor cells islands surrounded and infiltrated by lymphocytes and plasma cells.


name: Grade 5 Lower Extremity Soft Tissue Necrosis, CTCAE


name: Advanced Primary Malignant Central Nervous System Neoplasm

description: A malignant neoplasm that arises from the central nervous system and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Electrocardiogram QT Corrected Interval Prolonged, CTCAE

description: Average QTc 481-500 ms


Stage II Bone Cancer AJCC v8

description: Stage II includes: IIA: (T1, N0, M0, G2 or G3); IIB: (T2, N0, M0, G2 or G3). T1: Tumor measuring 8 cm or less in greatest dimension. T2: Tumor measuring more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


name: Pathologic Stage II Merkel Cell Carcinoma AJCC v8

description: Stage II includes: IIA: (T2-3, N0, M0); IIB: (T4, N0, M0). T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Grade 4 Dermatitis Radiation, CTCAE

description: Life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated


name: Refractory Human Papillomavirus-Related Malignant Neoplasm

description: Human papillomavirus-related malignant neoplasm that does not respond to treatment.


Grade 2 Neonatal Hypotension, AE

description: An adverse event in a newborn characterized by persistent (greater than 60 minutes) hypotension; not affecting perfusion; requiring minor care changes (e.g. additional fluids).


name: Epstein-Barr Virus Infection Reactivation, CTCAE

description: A disorder characterized by the reactivation of Epstein-Barr virus (EBV).


Implant Pain

description: Pain localized to the site of the implanted device.


name: Grade 4 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Cecum Intra-Operative Injury, CTCAE


Lymph Node Mass

description: A benign or malignant solid pathologic process involving a lymph node.


Mental Status, CTCAE

description: An adverse event resulting in a change in a patient's intellectual capacity, emotional state, or general mental health.


name: Steroidogenic Acute Regulatory Protein Deficiency

description: Congenital lipoid adrenal hyperplasia (CLAH) due to loss-of-function mutations in the STAR gene, resulting in decreased or absent production of steroidogenic acute regulatory protein (StAR), which leads to deficient transport of cholesterol from the outer to the inner mitochondrial membrane.


Grade 2 Sinusitis, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Uterine Corpus Cancer by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to uterine corpus sarcomas: leiomyosarcomas, endometrial stromal sarcomas, and adenosarcomas. These sarcomas are staged according to the classification for uterine corpus sarcomas. (from AJCC 8th Ed.)


Adult Pure Erythroid Leukemia

description: A pure erythroid leukemia occurring in adults.


name: Grade 3 Ureteric Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 2 Salivary Gland or Saliva Changes, CTCAE


Endometrioid carcinoma of prostate

description: A usually aggressive invasive adenocarcinoma of the prostate gland composed of large glands containing tall columnar cells.  The columnar cells have abundant cytoplasm and are reminiscent of endometrial carcinoma.  This type of adenocarcinoma has a tendency to metastasize to the lung and penis.


name: Grade 2 Ureter Stricture or Stenosis, CTCAE


Cardiac Arrest, CTCAE

description: A disorder characterized by cessation of the pumping function of the heart.


Grade 5 Spinal Cord Compression, CTCAE

description: Death


Bone Infection, CTCAE

description: A disorder characterized by an infectious process involving the bones.


name: Grade 1 Inner Ear Intra-Operative Injury, CTCAE


name: Grade 1 Cecum or Appendix Hemorrhage, CTCAE


Colonic Ulcer, CTCAE

description: A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the colon.


Stage IVA Bladder Cancer AJCC v8

description: Stage IVA includes: (T4b, N0, M0); (Any T, Any N, M1a). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. (AJCC 8th ed.)


name: Grade 4 Gastrointestinal Stoma Leak, CTCAE


name: Grade 1 Middle Ear Intra-Operative Injury, CTCAE


Uterine Fistula

description: An abnormal communication between the uterus and another organ.


name: Grade 5 Prolonged Chest Tube Drainage or Air Leak After Pulmonary Resection, CTCAE


name: Metastatic malignant neoplasm to urinary system

description: The spread of a malignant neoplasm to the urinary system from an adjacent or distant anatomic site.


name: Grade 2 Ileum Infection with Unknown Absolute Neutrophil Count, CTCAE


Nevus spider congenital

description: A type of telangiectasia, comprised of a central red spot with radiating, red extensions, that is present at the time of birth.


Polyp Tip

description: The distal end of a polyp.


name: Grade 5 Kidney Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Lugano Classification Adult Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for adult Hodgkin lymphomas based on the Lugano classification criteria. Staging for adult Hodgkin lymphoma is the same as for the childhood counterpart. (from AJCC 8th Ed.)


Grade 2 Tracheitis, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Osteoclast-Rich Osteopetrosis

description: A form of osteopetrosis in which osteoclasts are abundant but have severely impaired resorptive function.


Esophageal Infection, CTCAE

description: A disorder characterized by an infectious process involving the esophagus.


name: Stage II Renal Pelvis and Ureter Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 4 Serum Glutamic Oxaloacetic Transaminase, CTCAE


Recurrent Fallopian Tube Adenocarcinoma

description: The reemergence of fallopian tube adenocarcinoma after a period of remission.


name: Grade 4 Intraoperative Endocrine Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Bulky Mediastinal Mass

description: When the maximum width of a mass is equal or greater than one-third of the internal transverse diameter of the thorax at the level of T5/6 on a PA CXR. Bulk at an alternate site is defined as any mass measuring 10 cm or more by any imaging study.


Neuroendocrine Tumor G3

description: A well-differentiated, high-grade epithelial neoplasm with neuroendocrine differentiation. It usually arises from the digestive system.


name: Grade 4 Sciatic Nerve Intra-Operative Injury, CTCAE


Gum Infection

description: An acute or chronic infectious process affecting the gums.


Grade 2 Pericarditis, CTCAE

description: Symptomatic pericarditis (e.g., chest pain)


name: Inflammatory fibroepithelial hyperplasia of oral mucous membrane caused by denture

description: A benign fibrous hyperplasia in the oral mucosa caused by the prolonged wear of ill-fitting denture.


Grade 1 Gastric Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Grade 4 Creatinine Increased, CTCAE

description: >6.0 x ULN


Grade 2 Anal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Amegakaryocytosis

description: A non-neoplastic, congenital or non-congenital disorder charcaterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


name: Grade 3 Aorta Artery Intra-Operative Injury, CTCAE


name: Grade 1 Neuroendocrine ACTH Deficiency, CTCAE


PSA Level Equal to Nadir Plus 2 ng/mL

description: A finding indicating that the blood concentration of prostate specific antigen in a subject's sample has increased by 2 ng/mL over the lowest value recorded for a sample from that subject.


name: Metastatic Plasmacytoid Urothelial Carcinoma

description: Plasmacytoid urothelial carcinoma that has spread to another anatomic site.


Grade 5 Arterial Injury, CTCAE

description: Death


Grade 3 External Ear Pain, CTCAE

description: Severe pain; limiting self care ADL


Grade 1 Bronchial Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Lugano Classification Stage II Adult Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: Lacrimal Gland Epithelial-Myoepithelial Carcinoma

description: A rare, slow-growing carcinoma that arises from the lacrimal gland. It is characterized by the presence of duct-like structures lined by two layers of cells, an inner layer composed of epithelial-type cells and an outer layer composed of clear, myoepithelial-type cells.


Grade 1 Papilledema, CTCAE

description: Asymptomatic; no visual field deficit


name: FIGO Stage IA Gestational Trophoblastic Tumor


name: Grade 2 Urinary Tract Obstruction, CTCAE

description: Symptomatic but no hydronephrosis, sepsis, or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated


name: Increased Concomitant Drug Peak Blood Concentration

description: Increased maximum (peak) concentration of a concomitant drug observed after its administration.


name: Testicular Neuroendocrine Tumor, Prepubertal-Type

description: A rare, usually well-differentiated neuroendocrine neoplasm that arises from the testis. It usually affects adults, and a minority of patients have carcinoid syndrome. It may occur in isolation or, less frequently, be associated with testicular teratoma. The majority of cases are not associated with isochromosome 12p or germ cell neoplasia in situ. The clinical course is usually benign.


name: Adult Pre-B Acute Lymphoblastic Leukemia

description: Pre-B acute lymphoblastic leukemia that occurs during adulthood.


Grade 4 Bronchial Obstruction, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


description: Dedifferentiated liposarcoma that is not amenable to surgical resection.


Stage IVA Vulvar Cancer AJCC v6

description: Stage IVA includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0).  N2: Bilateral regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IV Cervical Cancer FIGO 2009

description: Cervical carcinoma involving adjacent and distant organs. (FIGO 2009)


Abnormal Blood Gas Measurement

description: Arterial blood gas test results that are outside normal limits.


Secondary hemochromatosis

description: Hemochromatosis that is not inherited and is caused by iron overload from excessive consumption, multiple transfusions, or disorders of erythropoiesis.


Subarachnoid hematoma

description: A collection of blood into the space between the pia membrane and arachnoid membrane.


Astler-Coller C1 Rectal Carcinoma

description: Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


name: Stage IIIA Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIIA includes: T4, N0, M0.  T4: Stomach/duodenum/ampulla/jejunum/ileum: tumor invades visceral peritoneum (serosa) or invades other organs or adjacent structures; colon or rectum: tumor invades peritoneum or other organs.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 4 Chronic Kidney Disease, CTCAE

description: eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated


Cataract associated with radiation

description: A cataract resulting from exposure to radiation.


Intermediary Metabolism Disorder

description: An inborn metabolic disorder affecting the intermediary metabolism process. It results in accumulation of substances in the body that can cause acute or chronic intoxication.


Adverse effects

description: The term was used in various ways in the past, to describe unintended effects of medical intervention, usually negative (unfavourable), but also positive (favourable) ones. It is recommended that this term no longer be used and particularly should not be regarded as synonymous with adverse event or adverse reaction.


Grade 1 Cystitis Noninfective, CTCAE

description: Microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence


Grade 4 Neonatal Sinus Tachycardia, AE

description: A sinus tachycardia adverse event in a newborn characterized by life-threatening consequences; requiring urgent major care changes.


Childhood Pilomyxoid Astrocytoma

description: A pilomyxoid astrocytoma that occurs during childhood.


name: Grade 3 Vulva Intra-Operative Injury, CTCAE


name: Intraoperative Hepatobiliary Injury, CTCAE

description: A finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure.


name: Grade 4 Catheter Related Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 1 Forced Expiratory Volume Decreased, CTCAE

description: FEV1% (percentages of observed FEV1 and FVC related to their respective predicted values) 99-70% predicted


name: Grade 3 Nodal or Junctional Rhythm, CTCAE


name: Grade 1 Vaccination Site Lymphadenopathy, CTCAE

description: Local lymph node enlargement


Advanced Hodgkin Lymphoma

description: Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Non-Neoplastic Peritoneal and Retroperitoneal Disorder

description: A non-neoplastic disorder that affects the peritoneum and/or retroperitoneum.


name: Grade 4 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Fetal Chorionic Vasculitis

description: A neutrophilic infiltrate arising from fetal vessels in the chorionic plate and oriented towards the amniotic cavity.


Low Calcium Level

description: A lower than average level of calcium in a sample.


name: Chest Pain Along Left Upper Sternal Border

description: The location of the chest pain is along the left upper border of the sternum.


Small Intestinal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the small intestine.


Merkel Cell Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


name: Grade 1 Other Hepatobiliary and Pancreas, CTCAE


name: Grade 3 Peripheral Sensory Neuropathy, CTCAE

description: Severe symptoms; limiting self care ADL


name: Refractory Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that does not respond to treatment.


Gallbladder Infection

description: An acute or chronic infectious process affecting the gallbladder.


name: Hereditary Malignant Urinary System Neoplasm

description: A malignant urinary system neoplasm that has developed in relatives of patients with a history of malignant urinary system neoplasm.


Catheter Related Infection, CTCAE

description: A disorder characterized by an infectious process that arises secondary to catheter use.


name: Edema of the Trunk and Genital Area, CTCAE


Neoplasm of musculoskeletal system

description: A benign, intermediate, or malignant neoplasm that affects muscles and bones.


name: Low Grade Broad Ligament Serous Adenocarcinoma

description: A slow-growing serous adenocarcinoma that arises from the broad ligament. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


name: Grade 3 Pancreatic Endocrine Glucose Intolerance, CTCAE


Syringocystadenocarcinoma papilliferum

description: A sweat gland carcinoma usually arising from a pre-existing syringocystadenoma papilliferum.


Grade 2 Erythema Multiforme, CTCAE

description: Target lesions covering 10-30% BSA and associated with skin tenderness


name: Grade 4 Serum Glutamic Pyruvic Transaminase, CTCAE


name: Acute Myeloid Leukemia with Monoallelic CEBPA Mutation

description: An acute myeloid leukemia with single mutations of the CEBPA gene.


Stage IB Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth. (FIGO 2009)


Grade 1 Pharyngeal Mucositis, CTCAE

description: Endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated


Grade 1 Diarrhea, CTCAE

description: Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline


Grade 3 Salivary Gland Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 2 Vaginal Obstruction, CTCAE

description: Symptomatic; elective intervention indicated


name: Grade 5 Injury To Superior Vena Cava, CTCAE

description: Death


Cardiac Troponin I Increased, CTCAE

description: A finding based on laboratory test results that indicate increased levels of cardiac troponin I in a biological specimen.


Grade 4 Ventricular Fibrillation, CTCAE

description: Life-threatening consequences; hemodynamic compromise


Extrapyramidal Disorder, CTCAE

description: A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness.


name: Locally Advanced Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to nearby tissues or lymph nodes.


name: Locally Advanced Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that has spread to nearby tissues or lymph nodes.


name: Spinal Cord Intra-Operative Injury, CTCAE


Grade 2 Infective Myositis, CTCAE

description: Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)


name: Grade 2 Eye Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Adenocarcinoma with neuroendocrine differentiation

description: An invasive adenocarcinoma characterized by the presence of focal or extensive neuroendocrine differentiation.


name: Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE


Grade 1 Uterine Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Cutaneous Langerhans cell histiocytosis

description: Langerhans cell histiocytosis that affects the skin. It manifests with skin papules and plaques.


name: Grade 4 Gingiva Intra-Operative Injury, CTCAE


name: Grade 1 Hepatic Artery Intra-Operative Injury, CTCAE


Phantom Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.


name: Grade 2 Cornea Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Radiating Chest Pain Along Right Anterior Axillary Line

description: The location of the radiating chest pain is along the right anterior axillary line.


name: Grade 3 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


name: Grade 4 Other Hepatobiliary and Pancreas, CTCAE


Nontraumatic extradural hemorrhage

description: Bleeding into the epidural space that is not associated with physical trauma.


Stage I Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Gastroparesis, CTCAE

description: A disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine.


name: Grade 3 Oculomotor Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


name: Muscle Infection with Unknown Absolute Neutrophil Count, CTCAE


Caustic injury

description: Tissue corrosion or chemical burn.


Grade 4 Abdominal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Breast Adenolipoma

description: A breast hamartoma characterized by the presence of adipose tissue that contains entrapped glands.


name: Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1, Any G. M1: Distant metastasis. (AJCC 8th ed.)


name: Grade 2 Pancreas Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Uterus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Adult Acute Myeloid Leukemia with Maturation

description: An acute myeloid leukemia with maturation occurring in adults.


Atrial Flutter, CTCAE

description: A disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria.


name: Grade 3 Abdomen Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Suicidal Ideation, CTCAE

description: Specific plan to commit suicide with serious intent to die which requires hospitalization


Tertiary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that results from progression of secondary hyperparathyroidism in which the parathyroid glands secrete parathyroid hormone autonomously, despite the presence of elevated parathyroid hormone and calcium levels in the serum.


Grade 5 Hematoma, CTCAE

description: Death


Adult Oligodendroglial Tumor

description: An oligodendroglial tumor of the central nervous system occurring in adults.


name: Grade 2 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


name: Grade 3 Colon Stricture or Stenosis, CTCAE


Grade 1 Weight Gain, CTCAE

description: 5-<10% from baseline


name: Grade 5 Larynx Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Sinus Tachycardia, CTCAE

description: Symptomatic; non-urgent medical intervention indicated


Tumor Mass

description: A benign or malignant pathologic structure in any part of the body, resulting from a neoplastic accumulation of cells.


Rash Acneiform, CTCAE

description: A disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back.


Recurrent Myelofibrosis

description: The reemergence of myelofibrosis after a period of remission.


Metastatic Mesonephric Adenocarcinoma

description: Mesonephric adenocarcinoma that has spread from its original site of growth to another anatomic site.


Grade 3 Hemolysis, CTCAE

description: Transfusion or medical intervention indicated (e.g., steroids)


name: Locally Advanced Genitourinary System Carcinoma

description: A genitourinary system carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Post-kala-azar dermal leishmaniasis

description: A cutaneous form of leishmaniasis which sometimes occurs after visceral leishmaniasis treatment.  It is characterized by hypo-pigmented macules, papules, plaques, nodules, or facial erythema; and is considered to be a durable infection reservoir for visceral leishmaniasis.


Oligoclonal Bands

description: The presence of more than one immunoglobulin band in the serum, urine, or cerebrospinal fluid. It usually results from infectious or immunologic disorders.


Grade 2 Pruritus, CTCAE

description: Widespread and intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL


Vulvar Cancer by AJCC v8 Stage

description: A term that refers to the staging of vulvar cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all carcinomas of the vulva. Melanoma of the vulva is staged according to the classification for melanoma of the skin. (AJCC 8th Ed.)


name: Grade 3 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Aspiration, CTCAE

description: Death


Grade 3 Retinopathy of Prematurity, AE

description: An adverse event in a newborn characterized by type 1 prethreshold retinopathy of prematurity (ROP) (zone 1 any stage with plus disease; zone 1 International Classification of Retinopathy of Prematurity (ICROP) stage 3 without plus disease; zone 2 ICROP stage 2 or 3 with plus disease); threshold ROP; requiring major care changes (e.g. laser intervention, intravitreal anti-VEGF therapy or operative management).


IgA Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgA monoclonal immunoglobulin in the blood or urine.


name: Grade 5 Encephalomyelitis Infection, CTCAE

description: Death


Grade 1 Bloating, CTCAE

description: No change in bowel function or oral intake


Abnormal Blood Antidiuretic Hormone

description: A laboratory test result which indicates abnormal levels of antidiuretic hormone in the blood.


name: Digestive System Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The Ki-67 index is higher than 20%.


Intra-Abdominal Hemorrhage, CTCAE

description: A disorder characterized by bleeding in the abdominal cavity.


Foregut Neuroendocrine Tumor G1

description: A neuroendocrine tumor grade 1 that arises from the esophagus, stomach, or duodenum.


name: Grade 1 Esophagus Stricture or Stenosis, CTCAE


name: Grade 4 Central Nervous System Hemorrhage, CTCAE


Low lying placenta

description: A condition in which the placental edge is within 2 cm of but not covering the cervical os.


Refractory Prostate Adenocarcinoma

description: Prostate adenocarcinoma that is resistant to treatment.


name: Grade 5 Upper Airway Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Childhood Mullerian Papilloma

description: Mullerian papilloma that occurs during childhood.


name: Metastatic Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma which has spread from its original site of growth to another anatomic site.


Non dystrophic myotonia

description: A group of rare skeletal muscle ion-channel disorders caused by genetic mutations in the sodium and chloride channel genes. It is characterized by altered membrane excitability resulting in skeletal muscle stiffness. This group of myotonias is distinct from myotonic dystrophy because of the absence of systemic features or progressive weakness.


Traditional Serrated Adenoma

description: An adenoma that arises from the large intestine and the appendix.  It is characterized by prominent serration of the glands.


name: Acute on chronic graft-versus-host disease

description: Sudden decompensation of chronic graft versus host disease.


name: Grade 3 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Gallbladder Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the gallbladder. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Secondary malignant neoplasm of vulva

description: A malignant neoplasm that has spread to the vulva from another anatomic site.


Grade 3 Injection Site Reaction, CTCAE

description: Ulceration or necrosis; severe tissue damage; operative intervention indicated


name: Grade 1 Cranial Nerve IV Intra-Operative Injury, CTCAE


name: Grade 3 Abdomen NOS Intra-Operative Injury, CTCAE


Pharyngeal Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the pharynx.


name: Grade 5 Peripheral Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Fracture, CTCAE

description: Severe symptoms; displaced or open wound with bone exposure; limiting self care ADL; operative intervention indicated


Grade 3 Photophobia, CTCAE

description: Limiting self care ADL


Stage IA Merkel Cell Carcinoma AJCC v7

description: Stage IA includes: T1, pN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  pN0: No regional lymph node metastasis by pathologic examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Borderline Exocrine Pancreatic Neoplasm

description: A group of epithelial neoplasms that arise from the exocrine pancreatic tissue and have the potential to evolve into invasive malignant neoplasms.  This group includes the pancreatic intraepithelial neoplasias, non-invasive pancreatic mucinous-cystic neoplasms, pancreatic intraductal papillary-mucinous neoplasms, and pancreatic intraductal tubulopapillary neoplasms.


name: Metastatic Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


S-Beta Thalassemia

description: A disorder characterized by the body's inability to synthesize beta-globin chains, leading to the formation of abnormal hemoglobin and anemia. This inherited autosomal recessive blood disorder is caused by germline mutation of the HBB gene.


name: Grade 3 Cranial Nerve XI Intra-Operative Injury, CTCAE


name: Grade 4 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 3 Oral Cavity NOS Intra-Operative Injury, CTCAE


name: Adult Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11

description: An acute myeloid leukemia with t(16;16)(p13.1;q22); CBFB-MYH11 occurring in adults.


Stage IV Bone Cancer AJCC v8

description: Stage IV includes: IVA: (Any T, N0, M1a, Any G); IVB: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1a: Metastasis in the lung. M1b: Metastasis in the bone or other distant sites. (AJCC 8th ed.)


name: Grade 3 Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Larynx Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Infant Irritability, AE

description: An adverse event in a newborn characterized by mild, self-limiting, irritability, not affecting feeding and sleeping.


name: Grade 3 Salivary Gland Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Hemorrhoids, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Cecum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Bronchopulmonary Hemorrhage, CTCAE

description: Death


name: Grade 3 Urinary Electrolyte Wasting, CTCAE


name: Stage IA Pancreatic Cancer AJCC v6 and v7

description: Stage IA includes: T1, N0, M0. T1: Tumor limited to the pancreas, 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Recurrent Endometrial Mixed Cell Adenocarcinoma

description: The reemergence of endometrial mixed cell adenocarcinoma after a period of remission.


name: Refractory Malignant Nongerminomatous Germ Cell Tumor

description: Malignant nongerminomatous germ cell tumor that is resistant to treatment.


Adverse Event Severity Grade

description: A numeric value corresponding to the degree of severity of an adverse event.


name: Grade 3 Penis Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Carcinoma in situ of ampulla of Vater

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Grade 3 Hepatitis B Reactivation, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated


name: Grade 3 Sciatic Nerve Intra-Operative Injury, CTCAE


Poorly Differentiated Fibrosarcoma

description: A usually aggressive malignant neoplasm arising from the deep soft tissue.  It is characterized by the presence of poorly-differentiated spindle-shaped fibroblasts, collagenous stroma formation and increased mitotic activity.


name: Grade 5 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Seasickness

description: A sensation of discomfort associated with travel over water, which may include nausea, vomiting, dizziness, or sweating.


name: Grade 1 Urethra Intra-Operative Injury, CTCAE


Nail Infection, CTCAE

description: A disorder characterized by an infectious process involving the nail.


name: Grade 2 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Urethral Condyloma Acuminatum

description: A sexually transmitted papillary neoplasm that arises from the epithelial surface of the urethra, and caused by the human papillomavirus.


Acquired Factor I Deficiency

description: An acquired coagulation disorder characterized by the partial or complete absence of fibrinogen (factor I) activity in the blood.


Environmental or Occupational Exposure

description: The exposure to potentially harmful agents in the environment or to work-related environmental factors.


Body Temperature Associated Symptom

description: An alteration in body temperature outside the normal range.


Peritoneal Inclusion Cyst

description: A cyst that is located in the peritoneum and is lined by benign mesothelium.


Elevated Erythropoietin

description: A finding indicating elevated concentrations of erythropoietin in blood.


name: Grade 4 Skin Intra-Operative Injury, CTCAE


Compound Spitz Nevus

description: A Spitz nevus characterized by the presence of both junctional and dermal melanocytic components.


Esophageal Cancer by AJCC v6 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 6th edition.


Well Differentiated Fibrosarcoma

description: A well-differentiated malignant neoplasm arising from the deep soft tissues.  It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern.


Refractory Endometrial Adenocarcinoma

description: Endometrial adenocarcinoma that is resistant to treatment.


Luminal B Prostate Carcinoma

description: Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a higher proliferation score than the luminal A prostate carcinoma. Patients with luminal B prostate carcinoma have the poorest prognosis but respond better to postoperative androgen deprivation therapy compared to patients with non-luminal B prostate carcinoma.


name: Grade 5 Small Bowel Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Intentional Trauma

description: An injury that is not the result of an accident or natural causes.


Grade 2 Hypocalcemia, CTCAE

description: Corrected serum calcium of <8.0-7.0 mg/dL; <2.0-1.75 mmol/L; Ionized calcium <1.0-0.9 mmol/L; symptomatic


Toxic methemoglobinemia with cyanosis

description: Blue skin coloration due to elevated blood levels of methemoglobin. The degree of cyanosis is directly correlated to the concentration of methemoglobin in the blood. As methemoglobin is not suitable for carrying oxygen, hypoxemia becomes a serious sequela.


Grade 2 Vaginal Perforation, CTCAE

description: Invasive intervention not indicated


name: Metastatic Malignant Pancreatic Neoplasm

description: A malignant neoplasm that arises from the pancreas and has metastasized to another anatomic site.


name: Grade 3 Other Hepatobiliary and Pancreas, CTCAE


name: Grade 2 Intraoperative Renal Injury, CTCAE

description: Partial resection of injured organ/structure indicated


Tracheitis, CTCAE

description: A disorder characterized by an infectious process involving the trachea.


Pancreatic adenocarcinoma recurrent

description: The reemergence of pancreatic adenocarcinoma after a period of remission.


Generalized Edema, CTCAE

description: A disorder characterized by fluid accumulation in the tissues of the body including the skin.


Bronchopulmonary Dysplasia, AE

description: An adverse event in a newborn characterized by a lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates. The condition is defined based on treatment with supplemental oxygen for at least 28 days adjusted for the degree of prematurity.


Peritoneal and Retroperitoneal Neoplasm

description: A benign or malignant, primary or metastatic neoplasm that affects the peritoneum and/or retroperitoneum.


name: Grade 5 Thorax Soft Tissue Necrosis, CTCAE


name: Grade 2 Joint Intra-Operative Injury, CTCAE


name: Hodgkin's disease nodular sclerosis stage I subdiaphragmatic


Grade 2 Pancreatitis, CTCAE

description: Enzyme elevation; radiologic findings only


Grade 3 Stevens-Johnson Syndrome, CTCAE

description: Skin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment, and mucous membrane detachment)


Venous Injury, CTCAE

description: A finding of damage to a vein.


name: Grade 2 Uterus Stricture or Stenosis, CTCAE


Difficult Vascular Access

description: Access to the subject's vasculature is troublesome or formidable. (ACC)


name: acute myeloid leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2)

description: An acute myeloid leukemia associated with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) resulting in the reposition of a distal GATA2 enhancer to activate MECOM expression. It may present de novo or follow a myelodysplastic syndrome. The clinical course is aggressive.


External Ear Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the external ear region.


Grade 1 Psychosis, CTCAE

description: Mild psychotic symptoms


name: Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Upper Airway Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Hyponatremia, CTCAE

description: A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood.


Grade 5 Urethral Infection, CTCAE

description: Death


name: Grade 3 Middle Ear Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Psoriatic Juvenile Idiopathic Arthritis

description: A category of juvenile idiopathic arthritis defined by the presence of arthritis with a personal or family history of psoriasis, and features such as dactylitis and nail dystrophy.


Hepatic Thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the veins in the liver or hepatic artery.


Grade 5 Sinusitis, CTCAE

description: Death


Biliary Anastomotic Leak, CTCAE

description: A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures).


Grade 1 Neonatal Diarrhea, AE

description: An adverse event in a newborn characterized by an increase of 2-4 stools per day over baseline; mild increase in ostomy output compared to baseline.


Non-Neoplastic Soft Tissue Disorder

description: A non-neoplastic disorder that affects the soft tissue.


Intraoperative Endocrine Injury, CTCAE

description: A finding of damage to the endocrine gland during a surgical procedure.


Grade 4 Duodenal Obstruction, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 2 Intracranial Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Hyperplasia of pituitary gland

description: A rare condition characterized by hyperplasia and hypertrophy of the pituitary gland. It is caused by hypersecretion of hypothalamic stimulating hormones.


Recurrent Malignant Skin Neoplasm

description: Reemergence of a malignant skin neoplasm after a period of remission.


name: Grade 5 Vascular Disorders - Other, Specify, CTCAE

description: Death


Recurrent Malignant Scrotal Neoplasm

description: The reemergence of a malignant scrotal neoplasm after a period of remission.


Grade 1 Hypophysitis, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Metastatic malignant neoplasm to esophagus

description: A malignant neoplasm that has spread to the esophagus from another organ or system, or from another primary esophageal tumor. The primary esophageal tumor is not in continuity with the metastatic lesion. Representative examples of metastatic cancers to the esophagus include breast and lung metastatic carcinomas and melanomas.


Grade 4 Rash Acneiform, CTCAE

description: Life-threatening consequences; papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated


Adenomatosis, Pulmonary

description: This is a non-human neoplastic process described in sheep.


Grade 1 Personality Change, CTCAE

description: Mild personality change


Grade 5 Atelectasis, CTCAE

description: Death


name: Grade 4 Eye Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Visual Pathway Glioma

description: The reemergence of visual pathway glioma after a period of remission.


name: Grade 4 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Kidney Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Ischemia Cerebrovascular, CTCAE

description: Moderate symptoms


Grade 1 Periodontal Disease, CTCAE

description: Gingival recession or gingivitis; limited bleeding on probing; mild local bone loss


Grade 2 Wound Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 4 Esophageal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Acute Myeloid Leukemia with ZRSR2 Mutation

description: An acute myeloid leukemia associated with ZRSR2 gene mutation.


Stage IIIB Prostate Cancer AJCC v8

description: Stage IIIB includes: T3-4, N0, M0, PSA: Any, Grade Group 1-4; T3: Prostate cancer with extraprostatic tumor that is not fixed or does not invade adjacent structures. T4: Prostate cancer in which the tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Locally Advanced Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 4 Dental-Tooth Infection with Unknown Absolute Neutrophil Count, CTCAE


Edema Trunk, CTCAE

description: A disorder characterized by swelling due to excessive fluid accumulation in the trunk area.


name: Cutaneous T Lymphoblastic Leukemia/Lymphoma

description: T-lymphoblastic leukemia/lymphoma that affects the skin.


name: Recurrent Endometrial Mucinous Adenocarcinoma

description: The reemergence of endometrial mucinous adenocarcinoma after a period of remission.


name: Invasive Pancreatic Micropapillary Adenocarcinoma

description: An invasive pancreatic ductal adenocarcinoma characterized by the presence of clusters of malignant cells located within artifactual clear stromal spaces.


Grade 1 Akathisia, CTCAE

description: Mild restlessness or increased motor activity


Subphrenic Abscess

description: An abscess that is located in the anatomical space between the diaphragm and the liver and/or spleen.


name: Acute Myeloid Leukemia with MECOM Rearrangement

description: Acute myeloid leukemia characterized by rearrangement of the MECOM gene with various genes.


name: Grade 2 Small Intestinal Anastomotic Leak, CTCAE

description: Symptomatic; medical intervention indicated


name: Grade 2 Cranial Nerve II Neuropathy, CTCAE


name: Grade 4 Vagina Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Colonic Fistula, CTCAE

description: Invasive intervention indicated


Grade 2 GGT Increased, CTCAE

description: >2.5-5.0 x ULN if baseline was normal; >2.5-5.0 x baseline if baseline was abnormal


Stage III Cervical Cancer FIGO 2009

description: Cervical carcinoma involving lower vagina, pelvic sidewall, and ureters. (FIGO 2009)


Insomnia exacerbated

description: Insomnia that is made worse by other factors, including pain, physiological or psychological disorders, external causes, or pharmacologic interventions.


Grade 5 Apnea, CTCAE

description: Death


name: Recurrent Digestive System Neuroendocrine Carcinoma

description: The reemergence of a neuroendocrine carcinoma in any part of the digestive system after a period of remission.


name: Clonal Cytopenia of Undetermined Significance

description: Clinically meaningful cytopenia in one or more hematopoietic cell lineages. Clonal hematopoiesis is present with the variant allele frequency (VAF) equal or more that 2 percent. There is no other evidence of hematologic malignancy.


Stage IB2 Cervical Cancer AJCC v9

description: Stage IB2 includes: T1b2, N0, M0. T1b2: Tumor measuring more than 2 cm and equal or less than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 1 Rash Maculo-Papular, CTCAE

description: Macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness)


Sickening Pain

description: A sensation of discomfort or distress that makes the individual queasy or nauseated.


Grade 2 Skin Atrophy, CTCAE

description: Covering 10-30% BSA; associated with striae or adnexal structure loss


name: Chronic combined systolic and diastolic heart failure

description: Chronic heart failure due to reduced contractility of the left ventricle and which does not fill properly due to decreased compliance.


Grade 3 Budd-Chiari Syndrome, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; asterixis; mild encephalopathy


name: Locally Advanced Appendix Adenocarcinoma

description: Appendix adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 2 Neonatal Respiratory Insufficiency, AE

description: An adverse event in a newborn characterized by clinical evidence of increased respiratory distress without significant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); corrected by minor adjustments in current ventilatory support, supplemental oxygen or non-invasive support.


name: Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Restrictive Cardiomyopathy, CTCAE

description: Death


name: Refractory HIV-Related Lymphoproliferative Disorder

description: HIV-associated lymphoproliferative disorder that is resistant to treatment.


Refractory Barrett Esophagus

description: Dysplasia in Barrett esophagus that is resistant to treatment.


Prostatic Obstruction, CTCAE

description: A disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder).


Constipation, CTCAE

description: A disorder characterized by irregular and infrequent or difficult evacuation of the bowels.