Diffuse alveolar damage

description: Diffuse alveolar damage (DAD) describes a common histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis, and crack cocaine inhalation.


Freezing phenomenon

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Abdominal Neoplasms

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Abdominal symptom

description: A subjective manifestation of disease localized to the abdomen.


adenoviridae infectious disease

description: An infectious process caused by adenovirus. The virus may cause respiratory illness, conjunctivitis, gastroenteritis, and cystitis.


Adverse event

description: Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s).


amnionitis

description: Inflammation of the amnion.


disorder of appendix

description: A disease or disorder that involves the vermiform appendix.


arterial disorder

description: An impairment of the structure or function of the blood vessels which carry blood away from the heart.


Arterial stenosis

description: Narrowing or constriction of the inner surface (lumen) of an artery.


Abnormal sputum

description: Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin.


benign neoplasm

description: A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites.


urinary bladder disorder

description: A disease involving the urinary bladder.


male breast carcinoma

description: A malignant neoplasm involving the male breast.


breast disorder

description: A disease involving the breast.


Clostridium infectious disease

description: Infections with bacteria of the genus clostridium.


colonic neoplasm

description: A benign or malignant neoplasm that affects the colon. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colonic adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms.


communication disorder

description: A disorder characterized by an individual's inability to comprehend or share ideas or feelings because of an impairment in language, speech, or hearing.


Obstetric Labor Complications

description: Any unintended event during the labor process that makes delivery more difficult.


name: congenital anomaly of cardiovascular system

description: A disease that has its basis in the disruption of cardiovascular system development.


Abnormality of the mouth

description: An abnormality of the mouth.


cranial nerve neuropathy

description: A neoplastic or non-neoplastic disorder that affects one of the cranial nerves.


diaphragm disorder

description: A disease involving the diaphragm.


Abnormal eosinophil count

description: Any deviation from the normal number of eosinophils per volume in the blood circulation.


Eye Injuries

description: Damage to the eye.


eyelid disorder

description: A disease involving the eyelid.


Congenital anomaly of eyelid

description: The abnormal formation of the eyelid that is present at the time of birth.


Fistula of the female genital organs

description: An abnormal communication between a female reproductive system organ and another organ or cavity.


Deviation of finger

description: Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges.


Fetal Diseases

description: A non-neoplastic or neoplastic disorder which occurs in the fetus.


Abnormal foot morphology

description: An abnormality of the skeleton of foot.


Fracture of pelvis

description: A traumatic break in one or more of the bones that compose the bony structure of the pelvis.


Injury of gastrointestinal tract

description: Trauma to the gastrointestinal tract or accessory organs of digestions.


haemophilus infectious disease

description: Infections with bacteria of the genus haemophilus.


Abnormality of the hand

description: An abnormality affecting one or both hands.


Inflammation

description: A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.


ligament disorder

description: A disease or disorder that involves the ligament.


Limb injury

description: Trauma to an arm or leg.


lymphoproliferative syndrome

description: A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis).


mediastinal cancer

description: A malignant neoplasm involving the mediastinum


nutritional disorder

description: Any condition related to a disturbance between proper intake and utilization of nourishment.


iris disorder

description: A disease involving the iris.


laryngeal disorder

description: A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma.


legionellosis

description: Any disease caused by Legionella bacteria.


mental disorder

description: A disease that has its basis in the disruption of mental process.


metastatic neoplasm

description: A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology.


Motor Deficit

description: Loss of movement function.


nail infection

description: An infectious process affecting the nail.


malignant tumor of nasopharynx

description: A cancer that involves the nasopharynx.


Abnormality of the neck

description: An abnormality of the neck.


Abnormal neutrophil count

description: A deviation from the normal range of neutrophil cell counts in the circulation.


toxic or nutritional optic neuropathy

description: A disease with basis in optic nerve damage secondary to a toxic substance and/or nutritional deficiency.


human papilloma virus infection

description: An infectious process caused by a human papillomavirus. This infection can cause abnormal tissue growth.


Focal-onset seizure

description: A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures.


pericardium disorder

description: A disease involving the pericardium.


Perineal Pain

description: Painful sensation in the perineal area.


Peritoneal Diseases

description: A non-neoplastic or neoplastic disorder that affects the peritoneum.  Representative examples of non-neoplastic disorders include peritonitis and panniculitis.  Representative examples of neoplastic disorders include adenomatoid tumor, primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma.


pleural neoplasm

description: A benign or malignant neoplasm that involves the serous membrane that lines the lungs and thoracic cavity. Most pleural neoplasms are metastatic. Diffuse malignant mesothelioma is the most common primary malignant neoplasm of the pleura.


poisoning

description: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.


Injury of integument

description: Damage to the skin.


Fractured skull

description: A partial or complete breakage of the skull.


Disorder of soft tissue

description: A non-neoplastic or neoplastic disorder that affects the soft tissue.


vertebral column disorder

description: A disease involving the vertebral column.


spondylitis

description: The inflammation of a vertebra.


sudden sensorineural hearing loss

description: Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.


synovium disorder

description: A disease or disorder that involves the layer of synovial tissue.


Thoracic Injuries

description: Trauma to the chest.


gastrointestinal tuberculosis

description: Tuberculosis that involves any region of the gastrointestinal tract, mostly in the distal ileum and the cecum. In most cases, mycobacterium tuberculosis is the pathogen. Clinical features include abdominal pain; fever; and palpable mass in the ileocecal area.


central nervous system tuberculosis

description: A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with seizures, focal neurologic deficits, and intracranial hypertension. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as opportunistic infections, but also occur in immunocompetent individuals.


Upper Extremity Fracture

description: A traumatic break in one or more of the bones in the arm,  forearm, or hand.


vaginal disorder

description: A non-neoplastic or neoplastic disorder that affects the vagina. Representative examples include vaginal infection, vaginal polyp, and vaginal squamous cell carcinoma.


leukocyte disorder

description: A disease involving leukocytes.


anal carcinoma

description: A carcinoma that arises from epithelial cells of the anus


Poor appetite

description: A reduced desire to eat.


Cerebral cyst

description: A fluid filled sac within the cerebrum. It is can be congenital, trauma related or secondary to another medical condition for example an infarction.


colorectal carcinoma

description: A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas.


Proteus infectious disease

description: Infections with bacteria of the genus proteus.


Pseudomonas infection

description: Infections with bacteria of the genus pseudomonas.


Pulmonary vascular disorder

description: A category of non-neoplastic disorders that affect the blood vessels in the lungs.  Representative examples include pulmonary embolism, pulmonary hypertension, and arteriovenous malformations.


name: Renal function tests outside reference range


Injury of kidney

description: Trauma to the kidney.


kidney neoplasm

description: A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma.


Neonatal respiratory system disorder

description: A respiratory system disorder that occurs during the neonatal period. A representative example is the respiratory distress syndrome.


Rhinovirus infection

description: An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well.


lumbar disk degenerative disorder

description: Any degenerative disorder affecting one or more vertebral disks of the lumbar spine.


inner ear disorder

description: A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems.


polyp

description: A usually exophytic mass attached to the underlying tissue by a broad base or a thin stalk. Polyps can be neoplastic or non-neoplastic. Neoplastic polyps usually represent proliferations of the epithelium, and are commonly seen in the gastrointestinal tract. Polyps of the gastrointestinal tract are often called adenomas, are associated with dysplasia, and may eventually transform into carcinomas. Non-neoplastic polyps may be inflammatory, degenerative, or the result of malformations.


mitral valve disorder

description: A disease involving the mitral valve.


ovarian neoplasm

description: A benign, borderline, or malignant neoplasm involving the ovary.


benign neoplasm of pituitary gland

description: A benign neoplasm that involves the pituitary gland.


pulmonary valve disorder

description: A disease involving the pulmonary valve.


Disorder of vocal cord

description: A disorder affecting the vocal cords. Representative examples include vocal cord nodules, polyps, leukoplakia, dysplasia, and paralysis.


aortic valve disorder

description: A disease involving the aortic valve.


Borrelia infectious disease

description: Infections with bacteria of the genus borrelia.


Abnormal Echocardiogram

description: A history of having had an abnormal echocardiogram.


Fractured lower leg

description: Bone fracture anywhere in the tibia, fibula, or ankle.


name: Abnormality on pulmonary function testing

description: Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.


Acanthamoeba infectious disease

description: An infectious disease involving the Acanthamoeba.


Deformity

description: An anatomic abnormality that is either present at birth or appears later in life.


adjustment disorder

description: A category of psychiatric disorders which are characterized by emotional or behavioral symptoms that develop within 3 months of a stressor and do not persist for more than an additional 6 months after the stressor is no longer present.


Adverse drug response

description: An unpleasant or harmful reaction resulting from treatment with a drug.


name: Antidepressant drug level above therapeutic


autonomic neuropathy

description: An inherited or acquired peripheral neuropathy affecting the autonomic nervous system. It results in disruption of the involuntary body functions. Inherited causes include Fabry disease and porphyrias. Acquired causes include diabetes, uremia, hepatic disorders, vitamin deficiencies, toxins, and drug toxicities.


Bone lesion

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of bone.


bone marrow disorder

description: Any disease of the bone marrow.


name: Cardioactive drug level above therapeutic


carotid artery disorder

description: A disease involving the carotid artery segment.


chondromalacia

description: Pathological processes involving the chondral tissue (cartilage).


uterine cervix carcinoma in situ

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003


amrubicin

mrdef: Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, for used in the treatment of small-cell lung cancer (SCLC) in Japan.

description: A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol.


epidural abscess

description: Circumscribed collections of suppurative material occurring in the spinal or intracranial epidural space. The majority of epidural abscesses occur in the spinal canal and are associated with osteomyelitis of a vertebral body; analgesia, epidural; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, urinary incontinence, and fecal incontinence. Cranial epidural abscesses are usually associated with osteomyelitis of a cranial bone, sinusitis, or otitis media. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12)


name: Extranodal marginal zone B-cell lymphoma (MALT type)


Fat Necrosis

description: Destruction of adipose tissue caused by the activity of lipase on damaged fat cells.


Recurrent tumor

description: The reemergence of a neoplasm after a period of remission.


Abnormality of the nose

description: An abnormality of the nose.


Obstruction

description: Blockage of the normal flow of the contents of an anatomical passageway.


obstructive lung disease

description: Any disorder marked by obstruction of conducting airways of the lung. airway obstruction may be acute, chronic, intermittent, or persistent.


Parainfluenza Virus Infections

description: A viral infection caused by a parainfluenza virus, typically resulting in infections of the lower respiratory tract.


Parasomnia

description: An undesirable physical event or experience that occurs during the process of falling asleep, while asleep, or when waking up from sleep.


Pulmonary Function Test Decreased

description: A decrease in any of the parameters used to measure the mechanical function of the lungs and upper airway.


Pulmonary toxicity

description: Toxicity that impairs or damages the lung(s). This condition is often caused by the administration of a pharmaceutical agent that causes damage to the lungs.


Food intolerance

description: A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.


Malignant neoplasm of stomach stage IV

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 7th ed.)


gastric neoplasm

description: A benign or malignant neoplasm involving the stomach.


Gastrointestinal disorder congenital

description: An abnormality of the digestive system that is present at birth or detected in the neonatal period.


glomerulosclerosis

description: A hardening of the kidney glomerulus caused by scarring of the blood vessels.


Liver Lesion

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of the liver.


hepatobiliary disorder

description: A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma.


lung neoplasm

description: A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma.


Abnormal lymphocyte morphology

description: An abnormality of lymphocytes.


skin pigmentation disorder

description: A pigmentation disease that involves the zone of skin.


Renal Mass

description: An abnormal growth in the kidney.


viral respiratory tract infection

description: A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus.


Vascular Access Complication

description: Complications related to damage at the vascular access site. Examples include bleeding, formation of hematoma, aneurysm, pseudoaneurysm, or arteriovenous fistula, development of infection, and catheter thrombosis.


Venous occlusion

description: Blockage of venous return (flow of blood from the periphery back towards the right atrium) in a vein.


Brain Diseases, Metabolic

description: A group of neurologic disorders caused by alterations to the biochemical functioning of the brain. They are characterized by an altered level of consciousness and depressed cerebral functioning.


capillary disorder

description: A disease involving a capillary.


nasal disorder

description: A disease involving the nose.


Abnormal Urine Test Result

description: A laboratory test result indicating a finding outside the parameters of normal urine measurements.


paranasal sinus disorder

description: A disease involving the paranasal sinus.


Soft Tissue Infection

description: A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin.


spinal cord neoplasm

description: A neoplasm (disease) that involves the spinal cord.


Small intestinal stenosis

description: The narrowing or partial blockage of a portion of the small intestine.


Lipohypertrophy

description: Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.


Leukemia recurrent

description: The reemergence of leukemia after a period of remission.


Non-Cardiac Chest Pain

description: Pain in the chest unrelated to a heart disorder.


Tooth Fractures

description: Broken tooth affecting any portion of tooth: root fracture, crown-root, broken tooth (crown fracture), chipped tooth. A crown fracture can involve the pulp. Tooth fracture sequelae range in severity from cosmetic defects to tooth death. Involvement of the pulp is a more important indicator of severity of tooth fracture than is the amount of the tooth affected.


Scleroderma renal crisis

description: The onset of acute renal failure, normally coupled with marked hypertension in a patient with scleroderma.


Enterovesical Fistula

description: An abnormal communication between the urinary bladder and the intestine.


hypophysitis

description: Inflammation of the pituitary gland.


hyperamylasemia

description: Abnormally high level of amylase in the blood.


neutrophil actin dysfunction

description: Solitary or multiple, slightly raised, pigmented lesions with irregular borders, usually measuring more than 0.6cm in greatest dimension. Morphologically, there is melanocytic atypia and the differential diagnosis from melanoma may be difficult. Patients are at an increased risk for the development of melanoma.


facial spasm

description: Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face.


effusion

description: A collection of fluid in a body cavity, which may be the result of a non-neoplastic disorder (e.g. heart failure) or a tumor (e.g. carcinoma of the lung).


Non-Infectious Cystitis

description: An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis.


name: postural orthostatic tachycardia syndrome

description: A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart.


Macular scar

description: Scar tissue in the macula.


Fungal endophthalmitis

description: Inflammation of the lining of the ocular cavities, which results from a fungal infection.


name: Crouzon syndrome-acanthosis nigricans syndrome

description: Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features and premature synostosis of cranial sutures (Crouzon disease), associated with acanthosis nigricans (AN).


Metamorphopsia

description: A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank.


name: International normalized ratio fluctuation


Polypoidal choroidal vasculopathy

description: The presence of aneurysmal polypoidal lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization.


Hypophagia

description: Reduced ingestion of food.


Urinary bladder wall hypertrophy

description: Increase in thickness of the wall of the urinary bladder. This finding may be seen in conditions such as bladder outlet obstruction and may be accompanied by increased trabeculation of the bladder wall musculature.


name: Gene mutation identification test positive


spondylolisthesis

description: A condition in which there is forward displacement of a vertebral bone over the on below it.


name: Hyperglycemic hyperosmolar nonketotic syndrome


metastatic squamous cell carcinoma

description: A squamous cell carcinoma which has spread from its original site of growth to another anatomic site.


Perforation of bladder

description: A rupture in the bladder wall due to traumatic or pathologic processes.


Atlantoaxial instability

description: Abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly.


Upper motor neuron dysfunction

description: A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.


Cerebral artery stenosis

description: Narrowing or constriction of the inner surface (lumen) of a cerebral artery.


name: Pregnancy after post coital contraception


Rh Incompatibility

description: A complication during pregnancy; it occurs when the mother is Rh-negative and the infant is Rh-positive. This complication generally does not affect first-born Rh-positive babies. Rh-positive newborn babies from subsequent pregnancies develop complications of Rh incompatibility which include hemolysis, jaundice, enlarged liver and spleen, petechiae, hypotonia, neurologic damage, and heart problems.


Iris hypopigmentation

description: An abnormal reduction in the amount of pigmentation of the iris.


ichthyosis prematurity syndrome

description: Ichthyosis prematurity syndrome is a rare, syndromic congenital ichthyosis characterized by premature birth (at gestational weeks 30-32, in general) in addition to thick, caseous and desquamating epidermis, neonatal respiratory asphyxia, and persistent eosinophilia. After the perinatal period, a spontaneous improvement in the health of affected patients is observed and skin features (vernix caseosa-like scale) evolve into a mild presentation of flat follicular hyperkeratosis with atopy.


familial atrioventricular septal defect

description: A spectrum of septal defects involving the atrial septum; ventricular septum; and the atrioventricular valves (tricuspid valve; bicuspid valve). These defects are due to incomplete growth and fusion of the endocardial cushions which are important in the formation of two atrioventricular canals, site of future atrioventricular valves.


autism

description: Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior.


Arachnodactyly

description: Abnormally long and slender fingers ("spider fingers").


name: Lower respiratory tract infection bacterial


Sudden unexpected death in epilepsy

description: Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death.


name: Sleep disorder due to a general medical condition


Enteroviral encephalitis

description: Inflamation of the brain related to infection by an enterovirus.


name: Non-high-density lipoprotein cholesterol increased


Lichen planus-like keratosis

description: A benign intraepidermal squamoproliferative neoplasm characterized by irregular acanthosis, hyperkeratosis, parakeratosis, and prominent chronic inflammation.


heart septal defect

description: A congenital disorder characterized by the presence of an abnormal communication between the atria or the ventricles of the heart due to defects in the cardiac septum.


volvulus of midgut

description: A congenital abnormality in which the intestine is abnormally rotated (twisted). It may result in intestinal obstruction.


multiple system atrophy

description: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years.


neurodevelopmental disorder

description: A behavioral and cognitive disorder with onset during the developmental period that involves impaired or aberrant development of intellectual, motor, or social functions.


Multiple lentigines

description: Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots.


Gastrointestinal inflammation

description: Inflammation of the alimentary part of the gastrointestinal system.


name: Labeled drug-drug interaction medication error


name: Labeled drug-disease interaction medication error


extrapulmonary tuberculosis

description: A tuberculosis that occurs at body sites other than the lung.


Stoma Site Infection

description: An infectious process affecting a surgically created opening in the surface of the body.


Positive EBV Test

description: A laboratory test result indicating the presence of the Epstein-Barr virus in a biological sample.


Breakthrough pain

description: A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain.


desmoplastic small round cell tumor

description: Desmoplastic small round cell tumor (DSRCT) is an aggressive soft tissue cancer that typically arises in serous lined surfaces of the abdominal or pelvic peritoneum, and spreads to the omentum, lymph nodes and hematogenously disseminates especially to the liver. Extraserous primary location has been reported in exceptional cases.


Erosion of oral mucosa

description: Loss of the superficial layer of the oral mucosa usually resulting in a shallow or crusted lesion.


periodic limb movement disorder

description: Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)


Placental infarction

description: Interruption of the blood supply to a portion of the placenta, resulting in ischemic necrosis.


clodronic acid

mrdef: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

description: An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.


Feculent vomiting

description: Vomiting of material that is of fecal origin.


Device related infection

description: An infectious disorder caused by the use of a medical device.


Dactylitis

description: Inflammation of the fingers or toes. This may be accompanied by pain and discoloration.


Infusion Site Extravasation

description: Leakage of a pharmacologic or a biological substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation, and pain at the infusion site.


Abnormal breath sound

description: An anomalous (adventitious) sound produced by the breathing process.


Tachyphrenia

description: The sensation that thoughts are moving too quickly.


obsolete Joint laxity

description: Looseness or instability of a joint.


Head titubation

description: A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction.


plasmablastic lymphoma

description: An aggressive diffuse large B-cell lymphoma frequently arising in the setting of HIV infection and characterized by the presence of large neoplastic cells resembling B-immunoblasts which have the immunophenotypic profile of plasma cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, soft tissues, gastrointestinal tract, and bone.


name: immune reconstitution inflammatory syndrome

description: An inflammatory condition that arises after initiating antiretroviral therapy (ART) therapy in HIV-infected patients that results from restored immunity to specific infectious or non-infectious antigens.


latent tuberculosis infection

description: Mycobacterium tuberculosis infection that does not induce infectious expression of the disease in the affected person, although it can cause continuous immune response generated towards TB antigens; person having LTBI are asymptomatic and acting as a reservoir of active tuberculosis tuberculosis cases and Mycobacterium tuberculosis and run a 5-10% risk of reactivating tuberculosis throughout their lives.


name: Lower respiratory tract infection fungal


Mycotic pericarditis

description: Pericarditis that is caused by an infection with a fungal agent.


Dental Fistula

description: Localized collection of pus in the tissues that enclose the root of a tooth and is associated with the presence of a sinus tract.


Spontaneous hematomas

description: Spontaneous development of hematomas (hematoma) or bruises without significant trauma.


Post procedural hypothyroidism

description: Evidence of post-procedural hypothyroidism.


Urinary Tract Fistula

description: An abnormal communication between any part of the urinary system and another organ or cavity.


Lemierre syndrome

description: Lemierre syndrome is a rare, potentially lethal, oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to Fusobacterium necrophorum and that is characterized by septic thrombophlebitis of the internal jugular vein that leads to septic, usually pulmonary, embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain, and tonsillopharyngitis.


Bone marrow hypocellularity

description: A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.


Nephritic syndrome

description: A syndrome characterized by hematuria with dysmorphic red blood cells, red blood cell casts, and proteinuria; systemic manifestations may be present, including hypertension, edema, oliguria.


Oral Cavity Fistula

description: An abnormal communication between the oral cavity and the adjacent tissues.


Bronchial hemorrhage

description: Bronchial hemorrhage is a focal bleeding located in the bronchial system. It can be diagnosed by tracheobronchoscopy.


Ovarian Hemorrhage

description: Bleeding originating from the ovary.


Mucosal Infection

description: An acute or chronic infectious process affecting a mucosal surface.


Musculoskeletal Deformity

description: Congenital or acquired deformity of the musculoskeletal system.


Tracheal fistula

description: An abnormal communication between the trachea and another organ or anatomic site.


Vaginal fistula

description: The presence of a fistula of the vagina.


Esophageal Fistula

description: An abnormal communication between the esophagus and another organ or anatomic site.


Digestive System Anastomotic Leakage

description: Leakage due to breakdown of a gastrointestinal anastomosis.


name: Left ventricle outflow tract obstruction


Truncal obesity

description: Obesity located preferentially in the trunk of the body as opposed to the extremities.


Fine motor delay

description: Delayed acquisition of age appropriate motor milestones that produce small and precise movements.


Stress urinary incontinence

description: Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing.


central nervous system leukemia

description: Leukemia infiltrating the central nervous system structures.


name: Acute graft versus host disease in liver


name: Acute graft versus host disease in intestine


Tako-tsubo cardiomyopathy

description: Takotsubo cardiomyopathy (TC) is a recently described acute cardiac syndrome that mimics acute myocardial infarction and is characterized by ischemic chest symptoms, an elevated ST segment on electrocardiogram, and elevated levels of cardiac disease markers.


keratosis pilaris

description: A form of dry skin characterized by hair follicles plugged by scale.


Hypersexuality

description: Pathological persistent sexual disinhibiting behavior, directed towards oneself or others.


Toxic anterior segment syndrome

description: An acute postoperative inflammatory reaction in which a noninfectious substance enters the anterior segment of the eye and induces toxic damage to the intraocular tissues.


Tendon pain

description: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to a tendon.


latent autoimmune diabetes in adults

description: A type 1 diabetes mellitus that is characterized by a less intensive autoimmune process, highly variable β-cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, sharing features with both type 1 and type 2 diabetes mellitus.


human herpesvirus 8 infection

description: An infectious process caused by the human herpesvirus 8. This infection is associated with Kaposi sarcoma.


name: hematopoietic and lymphoid system neoplasm

description: Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003


name: Fetus affected by placental transfer of anticonvulsant


Recurrent Medulloblastoma

description: The reemergence of medulloblastoma after a period of remission.


Neuroblastoma recurrent

description: The reemergence of neuroblastoma after a period of remission.


Melanoma recurrent

description: The reemergence of a melanoma after a period of remission.


Recurrent ovarian cancer

description: The reemergence of ovarian carcinoma after a period of remission.


acute interstitial pneumonia

description: Acute interstitial pneumonia (AIP), also referred to as Hamman-Rich syndrome, is a rapidly progressive and histologically distinct form of idiopathic interstitial pneumonia.


name: Human herpesvirus 6 infection reactivation


Injury of liver

description: Damage to liver structure or function due to trauma or toxicity.


Treatment Failure

description: A lack of response to therapy.


alveolar periostitis

description: A condition sometimes occurring after tooth extraction, particularly after traumatic extraction, resulting in a dry appearance of the exposed bone in the socket, due to disintegration or loss of the blood clot. It is basically a focal osteomyelitis without suppuration and is accompanied by severe pain (alveolalgia) and foul odor. (Dorland, 28th ed)


Fistula Discharge

description: The leakage of a substance from a fistula.


Regurgitation

description: Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent.


Bronchial wall thickening

description: Radiological appearance of increased density around the walls of a bronchus or large bronchiole. This feature is thought to be related to edema involving the bronchial wall as well as the peribronchial interstitial space. If the cross section of a bronchus is captured in a radiograph or computed tomography image, it is said to have the appearance of a donut because of the central lucency representing the airway of the bronchus surrounded by a circular region of increased density.


Sleep-related eating disorder

description: Eating while asleep can be problematic, as it may involve potentially harmful behaviors like overeating or consuming raw meat.


osteoradionecrosis

description: Necrosis of bone following radiation injury.


disorder of pharynx

description: A non-neoplastic or neoplastic disorder that affects the pharynx. Representative examples include pharyngitis and carcinoma.


Radiation necrosis

description: Tissue necrosis due to radiation exposure.


cloacal exstrophy

description: A major birth defect representing the severe end of the spectrum of the exstrophy-epispadias complex (EEC) characterized by omphalocele, exstrophy, imperforate anus and spinal defects (also referred to as the OEIS complex), often associated with other malformations.


nephrogenic systemic fibrosis

description: Nephrogenic systemic fibrosis (NSF) is a rare systemic fibrosing condition observed in renally impaired patients and characterized by a hardening and thickening of the skin with fibrotic plaques or papules, pruritus, joint pain and stiffness, muscle weakness, limitation of range of motion, and yellowed eyes. It is generally associated with administration of gadolinium-based magnetic resonance imaging contrast agents (GBCA) in patients with kidney disease.


Rotavirus infection

description: Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.


Organizing pneumonia

description: Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities.


chromosomal disorder

description: Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)


Adverse reactions

description: Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.


Impaired vibratory sensation

description: A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.


mouth disorder

description: A disease involving the mouth.


Heart valve regurgitation

description: Dysfunction of one of the cardiac valves characterized by incomplete valve closure.


Toxic polyneuropathy

description: Polyneuropathy that is caused by exposure to toxins.


Skin plaque

description: A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter.


Hyperlipasaemia

description: A laboratory test result which indicates increased levels of lipase in a biologic specimen.


focal segmental glomerulosclerosis

description: A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.


Upper airway obstruction

description: Increased resistance to the passage of air in the upper airway.


oromandibular dystonia

description: Oromandibular dystonia (OMD) is a form of focal dystonia, affecting the lower part of the face and jaws. It is characterized by sustained or repetitive involuntary jaw and tongue movements and facial grimacing caused by involuntary spasms of the masticatory, facial, pharyngeal, lingual, and lip muscles.


name: myelodysplastic syndrome with multilineage dysplasia

description: Refractory cytopenias with multilineage dysplasia (RCMD) is a frequent subtype of myelodysplastic syndrome (MDS) characterized by 1 or more cytopenias in the peripheral blood and dysplasia in 2 or more myeloid lineages.


name: Eastern Cooperative Oncology Group performance status worsened


Malar rash

description: An erythematous (red), flat facial rash that affects the skin in the malar area (over the cheekbones) and extends over the bridge of the nose.


intellectual disability

description: A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group.


cerebral amyloid angiopathy

description: Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.


burning mouth syndrome

description: A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth.


Epithelial Microcyst

description: Very small, round vesicles containing fluid and cellular debris observed on the surface of the cornea under slit-lamp examination in some types of corneal dystrophy and in wearers of extended-wear lenses.


cardio-renal syndrome

description: A disorder of the heart and kidneys in which dysfunction of one of the organs induces dysfunction of the other organ.


Transaminitis

description: Abnormally high levels of alanine transaminase (ALT) and/or aspartate transaminase (AST) in the blood.


Lack of insight

description: Lack of insight (Anosognosia) is a neurological condition in which an individual is unaware of his or her own neurological deficit or psychiatric condition. Anosognosia can be associated with mental illness, dementia, and structural brain lesions and can affect an indviduals's conscious awareness of deficits involving judgment, emotions, memory, executive function, language skills, and motor ability.


name: Epstein-Barr virus-associated malignant lymphoproliferative disorder

description: A lymphoproliferative disorder associated with Epstein-Barr virus. This category includes, but is not limited to, Burkitt lymphoma, classic Hodgkin lymphoma, and lymphomas arising in immunocompromised individuals.


name: Creatinine clearance-glomerular filtration outside reference range


Decreased fetal movement

description: An abnormal reduction in quantity or strength of fetal movements.


name: myelodysplastic syndrome associated with isolated del(5q)

description: A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The bone marrow is usually hypercellular or normocellular with increased number of often hypolobated megakaryocytes. The peripheral blood shows macrocytic anemia. This syndrome occurs predominantly but not exclusively in middle age to older women. The prognosis is good and transformation to acute leukemia is rare. (WHO, 2001)


name: C-reactive protein outside reference range


name: Respiratory syncytial virus test positive


Pulmonary hypertensive crisis

description: Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output.


Facial asymmetry

description: An abnormal difference between the left and right sides of the face.


Pulmonary cyst

description: A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid.


Overlap syndrome

description: An autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. These typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and Sjogren syndrome; in pediatrics the respective pediatric entities are encountered.


name: Anti-citrullinated protein antibody detected


Schizoaffective disorder, bipolar type

description: Schizoaffective disorder with episodes of mania and depression.


Terminal insomnia

description: A type of insomnia characterized by waking up too early in the morning is known as early morning awakening. The termination of sleep must occur at least 30 minutes before the desired time.


autoimmune pancreatitis

description: Autoimmune pancreatitis (AIP) is a rare pancreatic disease characterized by chronic non-alcoholic pancreatitis that presents with abdominal pain, steatorrhea, obstructive jaundice and responds well to steroid therapy and is seen in two subforms: type 1 AIP which affects elderly males, involves other organs and has increased immunoglobin G4 (IgG4) levels and type 2 AIP which affects both sexes equally but presents at a younger age and has no other organ involvement or increased IgG4 levels.


name: tubulointerstitial nephritis and uveitis syndrome

description: An autoimmune disorder comprising tubulointerstitial nephritis and uveitis.


Delayed gross motor development

description: A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling.


acute kidney failure

description: Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria.


iotalamic acid

mrdef: A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.

status: OFP


bambuterol

mrdef: selective inhibitor of butyrylcholinesterase & acetylcholinesterase

description: A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline.


Subretinal fluid

description: Edema/fluid accumulating between the retinal pigment epithelium and Bruch's membrane.


Lung Injury

description: Damage to the lung from traumatic or pathologic processes.


idiopathic camptocormia

description: Idiopathic camptocormia is a postural disease characterized by an anterior flexion of the torso (during walking or standing) that resolves in the supine position and that is caused by weakness of the lumbar paraspinal muscles (spinal extensors), due to massive fatty infiltrations of posterior spinal muscles, without an identifiable etiology.


name: Disseminated mycobacterium avium complex infection


Reticulin Fibrosis of the Bone Marrow

description: Increased reticular fiber deposition within bone marrow.


Spinal Injuries

description: Damage to the spine that results in impaired function.


swine influenza

description: An acute viral respiratory infection caused by a strain of influenza virus which is endemic in swine (pigs). Rarely reported in humans prior to 2009, the disease is caused by a mutated strain of swine influenza A (H1N1) virus. It is highly contagious and spreads mainly through coughing and sneezing. Signs and symptoms include fever, chills, coughing, sore throat headache, muscle ache, and generalized weakness. Antiviral medications are most effective in the first two days of the illness.


Renal hemangioma

description: A rare hemangioma arising from the kidney.


Foreign Bodies

description: Extraneous material within the body.


Executive dysfunction

description: Cognitive, emotional, and behavioral difficulties that often occur in conjunction with frontal lobe disorders, including traumatic injury and dementia. It is also a feature of attention deficit disorder and other non-trauma-induced conditions.


name: Infective exacerbation of bronchiectasis


Motor delay

description: A type of Developmental delay characterized by a delay in acquiring motor skills.


refractory malignant neoplasm

description: A malignant neoplasm that does not respond to treatment.


name: Mycobacterium tuberculosis complex test positive


Chemical peritonitis

description: A non-infectious inflammation of the peritoneum.


Increased urine urobilinogen

description: An elevated concentration of urobilinogen in the urine.


Hypoxic-Ischemic Encephalopathy

description: Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.


hypertension, pregnancy-induced

description: A hypertensive disorder that develops during pregnancy.


Distributive shock

description: A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage


name: Infective pulmonary exacerbation of cystic fibrosis


name: Heparin-induced thrombocytopenia test positive


name: Intentional medical device removal by patient


pholcodine

A morphinane alkaloid that is a derivative of morphine with a 2-morpholinoethyl group at the 3-position.


xylazine

mrdef: An adrenergic alpha-2 agonist used as sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE

description: A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.


Hypocitraturia

description: A lower than normal concentration of citrate(3-) in the urine.


Stage I Ovarian Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0. T1: Tumor limited to ovaries (one or both).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Ovarian epithelial cancer stage II

description: Stage II includes: T2, N0, M0.  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Ovarian cancer stage III

description: Stage III includes: T3, N0, M0.  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


colon dysplasia

description: A morphologic finding indicating the presence of dysplastic glandular epithelial cells in the colonic mucosa. There is no evidence of invasion.


description: Aminopterin/Methotrexate embryofetopathy is a syndrome of developmental anomalies characterized by growth deficiency, facial dysmorphism and skull, limb and neural defects secondary to maternal exposure to aminopterin or methotrexate (MTX) during pregnancy.


Lower Urinary Tract Symptoms

description: Symptoms that result from pathologic processes affecting the urinary bladder and/or urethra. They include urinary frequency and urgency, dysuria, nocturia, incomplete voiding, and poor stream during urination.


Acute repetitive seizure

description: A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognizable by the primary clinician, carer or patient.


name: Expanded disability status scale score increased


Resting tremor

description: A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.


hemophagocytic syndrome

description: Hemophagocytic syndrome (HPS) is a rare immune disease and a potentially life-threatening disorder characterized by cytokine storm and overwhelming inflammation causing fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia, and hemophagocytosis in bone marrow, liver, spleen or lymph nodes. It can be either primary due to a genetic defect (primary hemophagocytic lymphohistiocytosis), or secondary to malignancies, to infections, most commonly with viruses such as Epstein-Barr virus or cytomegalovirus, human immunodeficiency virus, or to autoimmune disorders such as systemic lupus erythematosus or adult-onset Still disease (secondary hemophagocytic lymphohistiocytosis).


name: N-terminal prohormone brain natriuretic peptide abnormal


name: N-terminal prohormone brain natriuretic peptide increased


Environmental Exposure

description: Exposure to potentially harmful chemical, physical, or biological agents via the environment.


stiff-person syndrome

description: Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.


name: Chronic graft versus host disease in intestine


name: Chronic graft versus host disease in skin


name: Chronic graft versus host disease in liver


Cutaneous wound

description: A cutaneous wound is a defined as a disruption of normal anatomic structure and function of the skin that occurs owing to an injury of the skin. Wound healing is a dynamic, interactive process involving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. Wound healing has three phases: inflammation, tissue formation, and tissue remodeling, that overlap in time.


name: Amyloid related imaging abnormality-edema/effusion


Drug-Induced Liver Disease

description: Damage to the liver tissue due to drug overdose.


technetium Tc 99m mebrofenin

mrdef: A radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining.


description: Virus-associated trichodysplasia spinulosa is a rare infectious skin disease characterized by the development of follicular papules with keratin spicules in various parts of the body, predominantly in the face (e.g. nose, eyebrows, auricles), that is due to polyomavirus infection in immunocompromized patients.


autoimmune encephalitis

description: Inflammation of the brain secondary to an immune response triggered by the body itself.


Substance-induced psychotic disorder

description: A psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to substance use, intoxication or withdrawal.


name: Amyloid related imaging abnormality-microhaemorrhages and hemosiderin deposits


name: Inadequate aseptic technique in use of product


name: myelodysplastic syndrome with single lineage dysplasia

description: A myelodysplastic syndrome characterized by dysplasia seen in at least 10% of the early cells of 1 cell type (either red blood cells, white blood cells, or megakaryocytes) in the bone marrow.


Pancreatic steatosis

description: Fat infiltration in the pancreas.


name: Immune reconstitution inflammatory syndrome associated tuberculosis


name: Central Nervous System Fungal Infections


name: Post-injection delirium sedation syndrome


brachydactyly

description: A disease characterized by the presence of brachydactyly, including syndromic and non-syndromic forms.


name: preterm premature rupture of the membranes

description: A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation.


burkholderia infectious disease

description: Infections with bacteria of the genus Burkholderia.


name: Primary malignant neoplasm of unknown site


Recurrent Liver Carcinoma

description: The reemergence of liver carcinoma after a period of remission.


breast intraductal proliferative lesion

description: A group of non-invasive epithelial proliferations that occur in the ductal system of the breast. The vast majority of cases arise in the terminal ductal lobular units. This category includes atypical ductal hyperplasia, usual ductal hyperplasia, flat epithelial atypia, and ductal carcinoma in situ. There is an increased risk for subsequent development of invasive breast carcinoma.


breast ductal adenocarcinoma

description: A breast carcinoma arising from the ducts. While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast. Ductal carcinomas account for about two thirds of all breast cancers. Two types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. The latter often spreads to the axillary lymph nodes and other anatomic sites. The two forms of ductal carcinoma often coexist.


invasive lobular breast carcinoma

description: An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures.


Postural tremor

description: A type of tremors that is triggered by holding a limb in a fixed position.


Plasma cell myeloma recurrent

description: The reemergence of multiple myeloma after a period of remission.


adrenal gland cancer

description: A malignant neoplasm involving the adrenal gland


name: congenital isolated adrenocorticotropic hormone deficiency

description: A hypopituitarrium that is characterized by a decreased or absent production of adrenocorticotropic hormone by the pituitary gland.


name: reversible cerebral vasoconstriction syndrome

description: Reversible cerebral vasoconstriction syndrome (RCVS) is an infrequent cerebrovascular disorder characterized by severe headaches with or without focal neurological deficits or seizures, and a reversible segmental and multifocal vasoconstriction of cerebral arteries.


clear cell renal carcinoma

description: A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common.


ovarian teratoma

description: A non-seminomatous germ cell tumor arising from the ovary. It is characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). According to the level of differentiation of the tissues which comprise the tumor, ovarian teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal type-tissues. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor.


Decorticate Posture

description: A posture characterized by body rigidity, flexion of the arms over the chest, clenched fists,  and extension of the legs. It may indicate cerebral damage.


anal squamous cell carcinoma

description: A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC.


appendix cancer

description: A malignant neoplasm involving the vermiform appendix


pancreatic ductal adenocarcinoma

description: An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor.


anaplastic large cell lymphoma

description: Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell non-Hodgkin lymphoma, belonging to the group of CD30-positive lymphoproliferative disorders, which affects lymph nodes and extranodal sites. It is comprised of two sub-types, based on the expression of a protein called anaplastic lymphoma kinase (ALK): ALK positive and ALK negative ALCL.


name: drug rash with eosinophilia and systemic symptoms

description: DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6.


Pregnancy exposure

description: Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants.


name: Therapeutic drug monitoring analysis not performed


name: Therapeutic drug monitoring analysis incorrectly performed


Injury of musculoskeletal system

description: Damage to the muscles, bones and their supportive structural attachments.


pneumocystosis

description: Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localized to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.


name: Infection by Pneumocystis jirovecii (disorder)


developmental dysplasia of the hip

description: A spectrum of hip abnormalities commonly presenting in infancy involving the relationship between the femoral head and the acetabulum and that includes subluxation or dislocation at rest or upon provocation.


name: Hypothalamic pituitary adrenal axis suppression


name: Parenteral nutrition associated liver disease


Right ventricular dilatation

description: Enlargement of the chamber of the right ventricle.


name: Ectopic pregnancy with contraceptive device


name: Fetal heart rate deceleration abnormality


sulfaguanidine

mrdef: A sulfanilamide antimicrobial agent that is used to treat enteric infections.

description: A sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine


Reduced forced vital capacity

description: An abnormal reduction in the amount of air a person can expel following maximal inspiration.


Portal fibrosis

description: Fibroblast proliferation and fiber expansion from the portal areas to the lobule.


Benign ethnic neutropenia

description: Chronic neutropenia in the absence of secondary causes, other cytopenia, splenomegaly, lymphadenopathy, or increased risk of infection. It occurs more frequently in individuals of African, Middle Eastern, and West Indian descent.


language disorder

description: A category of disorders characterized by an impairment in the development of an individual's language capabilities, which is in contrast to his/her non-verbal intellect.


Device embolization

description: Movement of a medical device to an unintended location within the body with resulting obstruction of an organ or vessel.


Change in Therapeutic Response

description: Change in response to treatment or cure of a disorder or disease.


granulomatous dermatitis

description: An inflammatory reaction of the skin to various organic and inorganic antigens. It is characterized by tumor-like masses or nodules of granulomatous tissue comprised of activated histiocytes, epitheliod cells, and multinucleated giant cells.


Toxic Erythema of Chemotherapy

description: Painful red or purple patches, edematous plaques or blisters on the hands, feet, extremities or intertriginous regions; the onset can occur days to months after receiving chemotherapy.


name: Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: The reemergence of chronic myeloid leukemia, BCR-ABL1 positive after a period of remission.


name: Graft versus host disease in gastrointestinal tract


Internal hemorrhage

description: The presence of hemorrhage within the body.


mast cell activation syndrome

description: A clinically defined disease states with a largely unknown morphological background. Acute mast cell activation (MCA) is commonly seen in allergic reactions and often leads to the clinical signs and symptoms of anaphylaxis. Severe or even life‐threatening MCA may occur when the burden of mast cells is high and/or these cells are in an hyperactivated state. Mastocytosis may be associated with mast cell activation syndrome (MCAS).


intestinal tuberculosis

description: A tuberculosis that involves the intestine.


Demodex folliculitis

description: A demodicidosis that involves the hair follicle.


name: Disability assessment scale score increased


name: Drug monitoring procedure incorrectly performed


orbital pseudotumor

description: A nonspecific tumor-like inflammatory lesion in the orbit of the eye. It is usually composed of mature lymphocytes; plasma cells; macrophages; leukocytes with varying degrees of fibrosis. Orbital pseudotumors are often associated with inflammation of the extraocular muscles (orbital myositis) or inflammation of the lacrimal glands (dacryoadenitis).


Feeding Intolerance

description: Inability to achieve a full feeding volume.


name: Unmasking of previously unidentified disease


Poor fine motor coordination

description: An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.


Stenosis

description: Narrowing or stricture of a vessel, duct or canal.


central nervous system lupus

description: Inflammation that includes the brain, spinal cord and surrounding tissues secondary to systemic lupus erythematosus (SLE); it is associated with neurological and/or psychiatric features.


name: Documented hypersensitivity to administered product


enbucrilate

mrdef: A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.

smiles: CCCCOC(=O)C(=C)C#N

description: A macromolecule composed of repeating butyl 2-cyanopropanoate units.


name: Wrong technique in product usage process


name: Unintentional use for unapproved indication


name: Prescription drug used without a prescription


Delayed Graft Function

description: The need for dialysis within a week of kidney transplant.


BCGosis

description: Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.


Perforation

description: A hole or opening made through a membrane or other tissue or material.


Brain fog

description: Brain fog is a type of transient cognitive dysfunction that comprises a constellation of symptoms that impair intellectual functioning to a level that interferes with daily activities, commonly including forgetfulness, mental slowness, difficulty thinking or focusing, a perceived slowing of mental processing speed, inability to find the right words, a sensation that the mind went blank or is "cloudy". Brain fog tends to recur and may be triggered by factors such as physical fatigue, lack of sleep, and prolonged standing or may appear to occur spontaneously.


name: Osteonecrosis of external auditory canal


Hyperinsulinemic hypoglycemia

description: An increased concentration of insulin combined with a decreased concentration of glucose in the blood.


Intrusive thoughts

description: An unwelcome and persistent idea, image or thought that is upsetting to an individual.


infantile apnea

description: Infantile apnea is a cessation of respiratory air flow that may affect newborns or older children because of neurological impairment of the respiratory rhythm or obstruction of air flow through the air passages. The symptoms include cyanosis, pallor or bradycardia and snoring in case of obstructive apnea.


Epileptic encephalopathy

description: A condition in which epileptiform abnormalities are believed to contribute to the progressive disturbance in cerebral function. Epileptic encephalaopathy is characterized by (1) electrographic EEG paroxysmal activity that is often aggressive, (2) seizures that are usually multiform and intractable, (3) cognitive, behavioral and neurological deficits that may be relentless, and (4) sometimes early death.


Vitreous haze

description: Vitreous haze is the obscuration of fundus details by vitreous cells and protein exudation.


Cornea verticillata

description: Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea.


name: Accidental exposure to product packaging


Immune-mediated adverse reaction

description: An adverse event resulting from an immune system reaction to a drug or device. It can affect any organ or system.


ureterolithiasis

description: The presence of a calculus in the ureter of the kidney; this is most often composed of mineral salts and proteins.


neurosarcoidosis

description: A sarcoidosis that involves the nervous system.


paraneoplastic limbic encephalitis

description: A rare disorder characterized by degenerative changes in the limbic area of the brain. Causes include infections and autoimmune conditions; it may also manifest as a paraneoplastic syndrome, most often caused by small cell lung carcinoma. Signs and symptoms include behavioral changes, hallucinations and dementia.


pathological gambling

description: A disorder characterized by a preoccupation with gambling and the excitement that gambling with increasing risk provides. Pathological gamblers are unable to cut back on their gambling, despite the fact that it may lead them to lie, steal, or lose a significant relationship, job, or educational opportunity.


Neurasthenia

description: An episode of acute, severe anxiety or depression associated with an inability to function as normal.


name: Fractional exhaled nitric oxide increased


name: Behavioral and psychological symptoms of dementia


cholesterol embolism

description: Blocking of a blood vessel by cholesterol-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.


name: Transformation to acute myeloid leukemia


name: Drug effective for unapproved indication


EBV positive mucocutaneous ulcer

description: A rare Epstein-Barr virus-positive B-cell lymphoproliferative disorder that affects mucosal sites (including oral mucosa, palate, tonsils, and gastrointestinal tract) and skin. It presents with well-circumscribed, often painful ulcers. It is associated with immune suppression, including age-related and drug-induced immunosuppression. In the majority of cases the lesions regress either spontaneously or following withdrawal of the immunosuppression therapy.


name: Loss of personal independence in daily activities


name: Pancreatitis due to pancreatic duct obstruction


Cutaneous lymphoma

description: A lymphoma involving the skin.


Neoplasm, Residual

description: Evidence for remaining tumor following primary treatment that is only apparent using highly sensitive techniques.


hairy tongue

description: A benign condition affecting the dorsum of the tongue. It is characterized by defective desquamation resulting in elongation of the filiform papillae. The dorsum of the tongue has a furry appearance and is usually stained black.


Sickness

description: A state of ill health, bodily malfunction, or discomfort.


malakoplakia

description: Malakoplakia is a chronic multisystem granulomatous inflammatory disease characterized by the presence of single or multiple soft plaques on various organs of the body.


vascular hyalinosis

description: A syndrome characterized by progressive hyalinosis involving capillaries and often arterioles and small veins of the digestive tract, kidneys, and idiopathic cerebral calcifications. It has been described in three sisters born to non-consanguineous parents. All three patients also had poikilodermia and graying hair, as well as severe diarrhea, rectal bleeding, malabsorption and subarachnoid hemorrhage.


name: Gastrointestinal vascular malformation hemorrhagic


name: Increased reactive oxygen species production

description: An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage.


B-cell aplasia

description: A condition characterized by extremely low B-cell counts. It occurs when anti-CD19 CAR T-cells attack and kill CD19-expressing B-lymphocytes.


name: Product administered at inappropriate site


phaeohyphomycosis

description: An opportunistic fungal infection caused by any of a variety of normally saprophytic fungi with hyaline hyphal elements. For example, Fusarium spp. infect neutropenic patients to cause pneumonia, fungemia, and disseminated infection with cutaneous lesions.


Body Substance Discharge

description: The leakage of a substance from an orifice or wound.


name: Incorrect route of product administration


name: Product use in unapproved therapeutic environment


name: Inappropriate schedule of product administration


name: Intercepted product administration error


name: Product administered to patient of inappropriate age


name: Incorrect product administration duration


central nervous system vasculitis

description: Vasculitis affecting the blood vessels of the brain and/or spinal cord.


Plasma cell myeloma refractory

description: Multiple myeloma that is resistant to treatment.


Vogt-Koyanagi-Harada disease

description: A bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations.


Neonatal seizure

description: A seizure occurring within the neonatal period (28 days beyond the full term date).


Oligoarthritis

description: A type of arthritis that affects up to four joints in the first six months of disease.


name: Philadelphia positive chronic myeloid leukemia


name: Autoimmune inflammation of skeletal muscle


name: Post 5-alpha-reductase inhibitor syndrome


name: Undetermined manner of death, suicide suspected


Taste Disorders

description: Conditions characterized by an alteration in the ability to perceive taste.


name: New onset diabetes after transplantation


name: Infusion related hypersensitivity reaction


Cerebral venous sinus thrombosis

description: An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses.


Bronchiolitis Obliterans Syndrome

description: Bronchiolitis obliterans following lung or allogeneic hematopoietic cell transplantation.


cell-associated neurotoxicity

description: Neurotoxicity associated with immune effector cell therapy. It may be characterized by aphasia, altered level of consciousness, motor weakness, seizures, and cerebral edema.


Subcapsular renal hematoma

description: A collection of blood between the renal capsule and the renal parenchyma.


name: Chronic graft versus host disease in eye


name: Failure of child resistant product closure


Congestive hepatopathy

description: Chronic passive congestion of the liver secondary to right heart failure. Elevation of central venous pressure leads to restriction of the hepatic circulation. Prolonged hepatic venous pressure may lead to liver fibrosis and cirrhosis.


Biliary tract obstruction

description: Obstruction affecting the biliary tree.


name: Disseminated varicella zoster virus infection


mercuric chloride

mrdef: Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.

smiles: Cl[Hg]Cl

description: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.


long COVID-19

description: A chronic disease triggered by acute COVID-19 infection that is characterized by persistent symptoms following the acute phase of the SARS-CoV-2 infection, which may include fatigue, coughing, dyspnea, clouding of mentation, sleep disturbances, exercise intolerance and autonomic symptoms including tachycardia upon mild exercise or standing, night sweats, temperature dysregulation, gastroparesis, constipation or loose stools, and peripheral vasoconstriction.


name: ABCC8_RAT ATP-binding cassette sub-family C member 8 (sprot)

description: An ATP-binding cassette sub-family C member 8 that is encoded in the genome of rat.


name: TRPM4_RAT Transient receptor potential cation channel subfamily M member 4 (sprot)

description: A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of rat.


kojic acid

A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae.


name: EYA2_HUMAN Eyes absent homolog 2 (sprot)

description: An eyes absent homolog 2 that is encoded in the genome of human.


name: BT3A1_HUMAN Butyrophilin subfamily 3 member A1 (sprot)

description: A butyrophilin subfamily 3 member A1 that is encoded in the genome of human.


name: FFAR3_HUMAN Free fatty acid receptor 3 (sprot)

description: A free fatty acid receptor 3 that is encoded in the genome of human.


name: SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (sprot)

description: A phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 that is encoded in the genome of human.


estramustine phosphate

description: A steroid phosphate which is the 17-O-phospho derivative of estramustine.


name: CAH11_HUMAN Carbonic anhydrase-related protein 11 (sprot)

description: A carbonic anhydrase-related protein 11 that is encoded in the genome of human.


name: DDAH1_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (sprot)

description: An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human.


RASK_HUMAN GTPase KRas (sprot)

A GTPase KRas that is encoded in the genome of human.


name: HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (sprot)

description: An MHC class I histocompatibility antigen A alpha chain that is encoded in the genome of human.


evans blue

mrdef: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.

status: OFM


name: LUCI_PHOPY Luciferin 4-monooxygenase (sprot)


indoprofen

mrdef: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)

description: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.


name: PPBI_HUMAN Intestinal-type alkaline phosphatase (sprot)

description: An intestinal alkaline phosphatase that is encoded in the genome of human.


name: GTR2_HUMAN Solute carrier family 2, facilitated glucose transporter member 2 (sprot)

description: A solute carrier family 2, facilitated glucose transporter member 2 that is encoded in the genome of human.


name: MIF_HUMAN Macrophage migration inhibitory factor (sprot)

description: A macrophage migration inhibitory factor that is encoded in the genome of human.


name: PLCG1_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (sprot)

description: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 that is encoded in the genome of human.


thiram

mrdef: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.

smiles: CN(C)C(=S)SSC(=S)N(C)C

description: An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.


name: LYOX_HUMAN Protein-lysine 6-oxidase (sprot)

description: A protein-lysine 6-oxidase that is encoded in the genome of human.


name: KDM5A_HUMAN Lysine-specific demethylase 5A (sprot)

description: A lysine-specific demethylase 5A that is encoded in the genome of human.


name: STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta (sprot)

description: A signal transducer and activator of transcription 1 that is encoded in the genome of human.


name: TTPA_HUMAN Alpha-tocopherol transfer protein (sprot)

description: An alpha-tocopherol transfer protein that is encoded in the genome of human.


name: STA5B_HUMAN Signal transducer and activator of transcription 5B (sprot)

description: A signal transducer and activator of transcription 5b that is encoded in the genome of human.


name: NR1H2_HUMAN Oxysterols receptor LXR-beta (sprot)

description: An oxysterols receptor LXR-beta that is encoded in the genome of human.


ubenimex

mrdef: growth inhibitor; RN given refers to ((L-Leu)-(S-(R*,S*)))-isomer; structure


name: PSA_HUMAN Puromycin-sensitive aminopeptidase (sprot)

description: A puromycin-sensitive aminopeptidase that is encoded in the genome of human.


name: GSTO1_HUMAN Glutathione S-transferase omega-1 (sprot)

description: A glutathione S-transferase omega-1 that is encoded in the genome of human.


name: ADA2C_MOUSE Alpha-2C adrenergic receptor (sprot)

description: An alpha-2C adrenergic receptor that is encoded in the genome of mouse.


NRAM_I63A3 Neuraminidase (sprot)

A neuraminidase subtype N8 (Influenza A virus) that is encoded in the genome of the H3N8 strain strain A/Duck/Ukraine/1/1963.


name: NR1H3_HUMAN Oxysterols receptor LXR-alpha (sprot)

description: An oxysterols receptor LXR-alpha that is encoded in the genome of human.


ELAV3_HUMAN ELAV-like protein 3 (sprot)

An ELAV-like protein 3 that is encoded in the genome of human.


name: TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (sprot)

description: A transcriptional enhancer factor TEF-3 that is encoded in the genome of human.


niflumic acid

mrdef: An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.


name: Q4QEW7_LEIMA Dihydroorotate dehydrogenase (fumarate) (trembl)


name: DYR_STRPN Dihydrofolate reductase (sprot)


name: BRDT_HUMAN Bromodomain testis-specific protein (sprot)

description: A bromodomain testis-specific protein that is encoded in the genome of human.


name: CP51_TRYCC Sterol 14-alpha demethylase (sprot)

description: A protein that is a translation product of any of the 2 copies of the CYP51 gene in Trypanosoma cruzi strain CL Brener.


name: PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (sprot)

description: A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human.


name: LOXL4_HUMAN Lysyl oxidase homolog 4 (sprot)

description: A lysyl oxidase homolog 4 that is encoded in the genome of human.


name: NEK1_HUMAN Serine/threonine-protein kinase Nek1 (sprot)

description: A serine/threonine-protein kinase Nek1 that is encoded in the genome of human.


name: PXL2A_HUMAN Peroxiredoxin-like 2A (sprot)

description: A peroxiredoxin-like 2A that is encoded in the genome of human.


name: FTO_HUMAN Alpha-ketoglutarate-dependent dioxygenase FTO (sprot)

description: An alpha-ketoglutarate-dependent dioxygenase FTO that is encoded in the genome of human.


name: CISD1_HUMAN CDGSH iron-sulfur domain-containing protein 1 (sprot)

description: A CDGSH iron-sulfur domain-containing protein 1 that is encoded in the genome of human.


POLK_HUMAN DNA polymerase kappa (sprot)

A DNA polymerase kappa that is encoded in the genome of human.


name: LOXL2_HUMAN Lysyl oxidase homolog 2 (sprot)

description: A lysyl oxidase homolog 2 that is encoded in the genome of human.


name: TRPC3_HUMAN Short transient receptor potential channel 3 (sprot)

description: A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human.


clemizole

A member of the class of  benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.


name: ACTHR_MOUSE Adrenocorticotropic hormone receptor (sprot)

description: An adrenocorticotropic hormone receptor that is encoded in the genome of mouse.


name: Q8IAU3_PLAF7 Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (trembl)


P2RX7_HUMAN P2X purinoceptor 7 (sprot)

A P2X purinoceptor 7 that is encoded in the genome of human.


oxatomide

mrdef: orally active H1-histamine receptor antagonist used to treat chronic urticaria and allergic rhinitis

description: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug.


name: TRPC6_HUMAN Short transient receptor potential channel 6 (sprot)

description: A short transient receptor potential channel 6 that is encoded in the genome of human.


name: TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 (sprot)

description: A transient receptor potential cation channel TRPV2 that is encoded in the genome of human.


name: GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of human.


name: GBRA2_HUMAN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human.


name: GBRA3_HUMAN Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of human.


name: GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of human.


name: GBRG1_HUMAN Gamma-aminobutyric acid receptor subunit gamma-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit gamma-1 that is encoded in the genome of human.


name: GBRG2_HUMAN Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit gamma-2 that is encoded in the genome of human.


name: GBRG3_HUMAN Gamma-aminobutyric acid receptor subunit gamma-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit gamma-3 that is encoded in the genome of human.


CDD_HUMAN Cytidine deaminase (sprot)

A cytidine deaminase that is encoded in the genome of human.


name: TNR17_HUMAN Tumor necrosis factor receptor superfamily member 17 (sprot)

description: A tumor necrosis factor receptor superfamily member 17 that is encoded in the genome of human.


name: FCGR1_HUMAN High affinity immunoglobulin gamma Fc receptor I (sprot)

description: A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of human.


name: FCG3A_HUMAN Low affinity immunoglobulin gamma Fc region receptor III-A (sprot)

description: A low affinity immunoglobulin gamma Fc region receptor III-A that is encoded in the genome of human.


name: IGHG1_HUMAN Immunoglobulin heavy constant gamma 1 (sprot)

description: An immunoglobulin heavy constant gamma 1 that is encoded in the genome of human.


name: IGHG2_HUMAN Immunoglobulin heavy constant gamma 2 (sprot)

description: An immunoglobulin heavy constant gamma 2 that is encoded in the genome of human.


name: IGHG3_HUMAN Immunoglobulin heavy constant gamma 3 (sprot)

description: An immunoglobulin heavy constant gamma 3 that is encoded in the genome of human.


name: IGHG4_HUMAN Immunoglobulin heavy constant gamma 4 (sprot)

description: An immunoglobulin heavy constant gamma 4 that is encoded in the genome of human.


name: KLK3_HUMAN Prostate-specific antigen (sprot)

description: A prostate-specific antigen that is encoded in the genome of human.


name: HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (sprot)

description: A 2-hydroxyacid oxidase 1 that is encoded in the genome of human.


alexidine

mrdef: until June 1975 was mistakenly treated as synonym for chlorhexidine; RN given refers to parent cpd

description: An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.


name: PTPM1_HUMAN Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (sprot)

description: A protein-tyrosine phosphatase mitochondrial 1 that is encoded in the genome of human.