name: postlingual non-syndromic genetic hearing loss

description: Postlingual non-syndromic genetic deafness is a rare, genetically highly heterogeneous otorhinolaryngologic disease, resulting from inner and/or middle ear or hearing nerve anomalies, typically characterized by progressive, bilateral, moderate to profound hearing loss (mean sensorineural hearing impairment equal to 40 dB or more for 500-, 1,000-, and 2,000-Hz frequency tones in the better ear) which occurs after the onset of speech development and is not associated with visible external ear abnormalities or any other medical problems. Language development is not initially significantly delayed.


Circumscribed Morphea

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A type of morphea in which the lesions are circular or ovoid, and may be superficial or deep. The superficial lesions can have an indurated, waxy, ivory colored center with surrounding erythema or violaceous color during the active stage. Deep lesions can be sclerotic and depressed from underlying atrophy, and may show minimal skin color changes. When there are several (greater than or equal to 4), larger (greater than 3cm) lesions on two or more body areas this is classified as "generalized morphea".


Plaque morphea

description: Circumscribed morphea in which the lesions are restricted to the skin and the immediately underlying subcutaneous tissues.


Deep Circumscribed Morphea

description: Circumscribed morphea in which the lesions are found in the deep dermis, panniculus, fascia, or superficial muscle.


name: Unresectable Skin Squamous Cell Carcinoma

description: Skin squamous cell carcinoma that is not amenable to surgical resection.


Unresectable Skin Carcinoma

description: Skin carcinoma that is not amenable to surgical resection.


Unresectable Skin Basal Cell Carcinoma

description: Basal cell carcinoma of the skin that is not amenable to surgical resection.


name: Unresectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that is not amenable to surgical resection.


Incongruent Visual Field Defect

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Non-identically shaped visual field defect in the same location in both eyes.


Central Visual Field Defect

description: Reduced or abnormal sight in the central visual field.


Peripheral visual field defect

description: Reduced or abnormal sight in the peripheral visual field.


Homonymous Visual Field Defect

description: A bilateral visual field defect on the same side of visual space of each eye (right or left).


Heteronymous Visual Field Defect

description: A bilateral visual field defect on opposite sides of the visual space of each eye (right or left).


Congruent Visual Field Defect

description: Identically shaped visual field defect in the same location in both eyes.


name: Conduction Abnormality and Atrioventricular Heart Block, CTCAE


Grade 1 Mobitz Type I, CTCAE

description: Asymptomatic, intervention not indicated


Grade 3 Sick Sinus Syndrome, CTCAE

description: Symptomatic, intervention indicated


Grade 3 Mobitz Type I, CTCAE

description: Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)


name: Grade 4 Conduction Abnormality NOS, CTCAE


Grade 5 Asystole, CTCAE

description: Death


name: Grade 1 Wolff-Parkinson-White Syndrome, CTCAE


name: Grade 2 Mobitz (Type) II Atrioventricular Block, CTCAE

description: Symptomatic; medical intervention indicated


Grade 1 Asystole, CTCAE

description: Periods of asystole; non-urgent medical management indicated


name: Grade 1 Mobitz (Type) II Atrioventricular Block, CTCAE


name: Grade 5 Wolff-Parkinson-White Syndrome, CTCAE


name: Grade 2 Conduction Abnormality NOS, CTCAE


name: Grade 3 Wolff-Parkinson-White Syndrome, CTCAE


Grade 5 Sick Sinus Syndrome, CTCAE

description: Death


name: Grade 5 Conduction Abnormality NOS, CTCAE


name: Grade 3 Conduction Abnormality NOS, CTCAE


name: Grade 4 Mobitz (Type) II Atrioventricular Block, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 1 Conduction Abnormality NOS, CTCAE


Mobitz Type I, CTCAE

description: A disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.


Sick Sinus Syndrome, CTCAE

description: A disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness.


name: Grade 2 Wolff-Parkinson-White Syndrome, CTCAE


Grade 2 Sick Sinus Syndrome, CTCAE

description: Symptomatic, intervention not indicated; change in medication initiated


name: Mobitz (Type) II Atrioventricular Block, CTCAE

description: A disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.


name: Grade 4 Wolff-Parkinson-White Syndrome, CTCAE


Grade 5 Mobitz Type I, CTCAE

description: Death


name: Grade 3 Mobitz (Type) II Atrioventricular Block, CTCAE

description: Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker); new onset


name: Grade 5 Mobitz (Type) II Atrioventricular Block, CTCAE

description: Death


alpha-L-fructopyranose

A L-fructopyranose with an alpha-configuration at the anomeric position.


name: Small Intestinal Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine.  It is characterized by the presence of malignant small cells.


name: Grade 3 Lower Extremity Artery Injury, CTCAE


N-acylammonia

A carboxamide obtained by the formal condensation of the carboxy group of any carboxylic acid with ammonia.


A pyrazinecarboxamide in which a 6-oxo-1,6-dihydropyrazine nucleus is substituted on C-5 by a 4-hydroxyphenyl group and on C-2 by a butylcarbamyl group. A synthetic determinant of cefadroxil, it is a promising tool for determining in vitro cross-reactivity to cefadroxil in amoxicillin-allergic patients.


name: Acute Liver Injury without Fulminant Failure Related to COVID-19

description: Acute liver injury associated with abnormal liver chemistries (greater than two times the upper limit of normal) in the absence of signs of hepatic failure (e.g., no coagulopathy or encephalopathy) in a patient with probable or confirmed acute COVID-19. This is usually mild, transient, and does not require intervention.


name: Grade 5 Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Pelvic Floor Muscle Weakness, CTCAE

description: Severe symptoms; limiting self care ADL


(S,S)-formoterol

An N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have S configuration.


Moderate Cardiac Valve Stenosis

description: The cardiac valve orifice is abnormally narrow, to a moderate degree. (ACC)


Grade 5 Renal Hemorrhage, CTCAE

description: Death


name: Grade 5 Toxic Epidermal Necrolysis, CTCAE

description: Death


Hemorrhage of rectum and anus

description: Bleeding originating from the rectal wall and anus.


nemonapride

A benzamide obtained by formal condensation of the carboxy group of 5-chloro-2-methoxy-4-(methylamino)benzoic acid with the amino group of 1-benzyl-2-methylpyrrolidin-3-amine.


An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2.


description: Hemophagocytic lymphohistiocytosis that is resistant to treatment.


Grade 2 Edema Limbs, CTCAE

description: >10-30% inter-limb discrepancy in volume or circumference at point of greatest visible difference; readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental ADL


Grade 3 Pancreatic Fistula, CTCAE

description: Invasive intervention indicated


Desmoplastic Neurotropic Melanoma

description: A desmoplastic melanoma characterized by the presence of nerve infiltration by atypical spindled melanocytes.


Ann Arbor Stage I AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Magnesium ammonium phosphate urolithiasis

description: Urolithiasis in which the composition of the stone(s) is predominantly magnesium ammonium phosphate.


Grade 5 Bronchial Infection, CTCAE

description: Death


name: Stage IIIB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 3 Cranial Nerve XI Neuropathy, CTCAE


name: Grade 3 Urethra Intra-Operative Injury, CTCAE


Stage IIIB Colon Cancer AJCC v8

description: Stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Colon Cancer AJCC v8

description: Stage III includes: IIIA: (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIC Colon Cancer AJCC v8

description: Stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIA Colon Cancer AJCC v8

description: Stage IIIA includes: (T1-T2, N1/N1c, M0); (T1, N2a, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Grade 1 Abdominal Pain, CTCAE

description: Mild pain


Abdominal Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the abdominal region.


Grade 2 Abdominal Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Grade 3 Abdominal Pain, CTCAE

description: Severe pain; limiting self care ADL


Childhood Malignant Skin Neoplasm

description: A malignant neoplasm that affects the skin and occurs during childhood.


Grade 3 Testicular Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


diester

A diester is a compound containing two ester groups.


(R)-malathion

A diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate that is the R-enantiomer of malathion.


(S)-nisoldipine

A methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate that has S configuration.


(S)-malathion

A diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate that is the S-enantiomer of malathion.


(S)-bitolterol

The (S)-enantiomer of bitolterol.


(R)-nisoldipine

A methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate that has R configuration.


(R)-nicardipine

The R-enantiomer of nicardipine.


(R)-bitolterol

The (R)-enantiomer of bitolterol.


name: Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIA includes: T1, N1, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Ectopic Meningioma

description: A meningothelial neoplasm that arises from an anatomic site outside the intracranial and intraspinal compartments.


Primary Middle Ear Meningioma

description: A rare extracranial meningioma that arises from the middle ear.


Primary Sinonasal Meningioma

description: A rare extracranial meningioma that arises from the sinonasal tract.


Grade 3 Seizure, CTCAE

description: New onset seizures (partial or generalized); multiple seizures despite medical intervention


name: Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Muscle Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 2 Hepatic Artery Intra-Operative Injury, CTCAE


Grade 2 Trismus, CTCAE

description: Decreased ROM requiring small bites, soft foods or purees


name: Hodgkin's disease mixed cellularity stage II subdiaphragmatic


name: Ann Arbor Stage II Mixed Cellularity Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Hodgkin's disease mixed cellularity stage II supradiaphragmatic


Childhood Sympathetic Paraganglioma

description: A sympathetic paraganglioma that occurs during childhood.


Childhood Paraganglioma

description: A paraganglioma that occurs during childhood.


Childhood Parasympathetic Paraganglioma

description: A parasympathetic paraganglioma that occurs during childhood.


Childhood Composite Paraganglioma

description: A composite paraganglioma that occurs during childhood.


name: Grade 1 Throat and Pharynx and Larynx Pain, CTCAE


DELTA-TOCOTRIENOL

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2.


chromanol

Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.


(S,R,S)-alpha-tocopherol

The (S,R,S)-stereoisomer of alpha-tocopherol.


beta-tocotrienol

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5 and 8 and a farnesyl chain at position 2. It has been isolated from various cultivars of wheat.


(R,R,S)-alpha-tocopherol

The (R,R,S)-stereoisomer of alpha-tocopherol.


GAMMA-TOCOPHEROL

A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.


A tocopherol in which the chroman-6-ol core is substituted by a methyl group at position 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.


(S,S,R)-alpha-tocopherol

The (S,S,R)-stereoisomer of alpha-tocopherol.


(R,S,R)-alpha-tocopherol

The (R,S,R)-stereoisomer of alpha-tocopherol.


tocol

A chromanol with a chroman-6-ol skeleton that is substituted at position 2 by a saturated or triply-unsaturated hydrocarbon chain consisting of three isoprenoid units.


tocopherol

A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.


ALPHA-TOCOTRIENOL

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.


beta-tocopherol

A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 5 and 8. While it is found in low concentrations in many vegetable oils, only cottonseed oil contains significant amounts.


(S,S,S)-alpha-tocopherol

The (S,S,S)-stereoisomer of alpha-tocopherol.


(S,R,R)-alpha-tocopherol

The (S,R,R)-stereoisomer of alpha-tocopherol.


alpha-tocopherol

A tocopherol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a 4,8,12-trimethyltridecyl group at position 2.


(R,S,S)-alpha-tocopherol

The (R,S,S)-stereoisomer of alpha-tocopherol.


GAMMA-TOCOTRIENOL

A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers.


name: Mismatch Repair-Deficient Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by mismatch repair (MMR) deficiency caused by inactivating methylation or less frequently mutation of an MMR gene (MLH1, PMS2, MSH2, or MSH6).


Grade 2 Kidney Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Stent restenosis

description: Fifty percent or greater stenosis within an existing stent. (ACC)


Uterine Corpus Neuroendocrine Tumor G1

description: A very rare, well-differentiated, low-grade neuroendocrine neoplasm that arises from the uterine corpus.


Stress ulcer

description: An ulcer due to stress.


Orbit Solitary Fibrous Tumor

description: A solitary fibrous tumor that arises from the orbit. Most of these tumors are benign.


Malignant neoplasm of exocervix

description: A malignant neoplasm that affects the exocervix.


name: Grade 5 Cervix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Superior Vena Cava Vein Injury, CTCAE


carboxamidine

Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom.


formamidines

Amidines with the general formula R(1)N=CHNR(2)R(3) (R(1), R(2), R(3) can be H).


Grade 1 Wrist Fracture, CTCAE

description: Mild; non-operative intervention indicated


name: Grade 5 Anus Stricture or Stenosis, CTCAE


Grade 3 Erythroderma, CTCAE

description: Erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL


Erythroderma, CTCAE

description: A disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.


Grade 4 Erythroderma, CTCAE

description: Erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated


Grade 2 Erythroderma, CTCAE

description: Erythema covering >90% BSA without associated symptoms; limiting instrumental ADL


Grade 5 Erythroderma, CTCAE

description: Death


Genital Human Papillomavirus Infection

description: Infection of the genitalia by human papillomavirus.


Iatrogenic Hypoparathyroidism

description: Hypoparathyroidism resulting from medical treatment or intervention.


Acquired Hypoparathyroidism

description: Hypoparathyroidism, the cause of which is not present at birth.


Hypoparathyroidism, Autosomal Recessive

description: Hypoparathyroidism associated with homozygous mutation(s) in the PTH gene, which encodes parathyroid hormone, or in the GCM2 gene, which encodes chorion-specific transcription factor GCMb.


Transient neonatal hypoparathyroidism

description: A disorder of decreased production of parathyroid hormone by the parathyroid gland in a newborn. It is due to maternal hyperparathyroidism. It may be characterized by hypocalcemic seizures in the first weeks of life.


Primary hypoparathyroidism

description: Abnormally low levels of parathyroid hormone due to a disorder originating within the parathyroid glands.


name: Grade 4 Fibrosis-Deep Connective Tissue, CTCAE


Circumscribed storiform collagenoma

description: A benign skin tumor characterized as a small, dome-shaped dermal nodule composed of fibroblasts in a dense collagenous background with storiform organization.  Rarely, multiple lesions can occur in connection with Cowden's disease.


Senile nevus

description: A benign skin lesion consisting of a cluster of capillaries at the surface of the skin, forming a red papular lesion.


chlorobenzophenone

A member of the class of benzophenones that is any substituted benzophenone in which at least one of the substituents is a chlorine.


organosilicon compound

An organosilicon compound is a compound containing at least one carbon-silicon bond.


organosiloxane

A siloxane where Si is substituted with organyl groups.


name: Grade 2 Mediastinum Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Feeding Intolerance, AE

description: An adverse event in a newborn characterized by mild feeding intolerance (e.g. increased gastric residual volume or abdominal distension); without discomfort; no change in care indicated.


Elevated AFP-L3

description: A finding indicating that elevated concentrations of alpha-fetoprotein (AFP) fraction L3 (AFP-L3) were detected in a sample. AFP-L3 represents a glycoform variant of AFP that is highly reactive with Lens culinaris-expressed agglutinin (LCA) due to the presence of an extra alpha-(1-6) fucose attached to the N-acetylglucosamine modification present in AFP.


AFP Level Finding

description: A finding that indicates the amount of alpha-fetoprotein tumor marker in a sample.


anilines

Any  aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives.


(R)-mosapride

A 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide that has (R)-configuration.


(R)-aminoglutethimide

The (3R)-enantiomer of aminoglutethimide.


(S)-mosapride

A 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide that has (S)-configuration.


fluorenes

An ortho-fused polycyclic arene in which the skeleton is composed of two benzene rings ortho-fused to cyclopentane.


Primary Insomnia

description: A sleep disorder characterized by difficulty initiating or maintaining sleep; this difficulty does not occur in the context of another sleep disorder and is not etiologically linked to a mental disorder, substance use, or a general medical condition.


tetrol

A polyol that contains 4 hydroxy groups.


A hydroxycalciol that is a synthetic fluorinated and deuterated analogue of vitamin D3 which exhibits vitamin D receptor superagonist and anti-cancer activity.


1alpha,23(S),25-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) bearing additional hydroxy substituents at positions 1, 23 and 25 (with 1alpha,23S-configuration). An intermediate in the degradation pathway of 1alpha,25-(OH)2D3.


(20S,23,24)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups  at positions 20 (with S-configuration), 23 and 24.


A vitamin D that is 19-norcalcitriol carrying an additional 3-hydroxypropyl substituent at position 2. A synthetic analogue of vitamin D, it exhibits anticancer properties.


nordihydroguiaretic acid

A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor.


(20S,23,25)-trihydroxyvitamin D3

A hydroxycalciol that consists of vitamin D3 (calciol) carrying additional hydroxy groups at positions 20 (with S-configuration), 23 and 25.


A hydroxycalciol that is calcitriol with a 4-hydroxybutoxy group at position 2.


Cor triloculare

description: A congenital anatomic anomaly in which the heart has only three chambers.


Grade 5 Urostomy Leak, CTCAE

description: Death


name: Splenic Manifestation of Chronic Lymphocytic Leukemia

description: Infiltration of the spleen by chronic lymphocytic leukemia. It primarily involves the white pulp.


Kaposi's sarcoma of oral cavity

description: Kaposi sarcoma arising from the oral cavity.


Parotid Gland Lipoma

description: A lipoma that arises from the parotid gland.


Grade 1 Irregular Menstruation, CTCAE

description: Intermittent/irregular menses for no more than 3 consecutive menstrual cycles


PYRAZINE

A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.


An  oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.


Grade 3 Headache, CTCAE

description: Severe pain; limiting self care ADL


Headache, CTCAE

description: A disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.


Grade 1 Headache, CTCAE

description: Mild pain


Grade 2 Headache, CTCAE

description: Moderate pain; limiting instrumental ADL


Gastric Anastomotic Leakage

description: Leakage due to breakdown of a gastric anastomosis.


azulenes

Any carbobicyclic compound whose skeleton consists of a cyclopentane ring ortho-fused to a cycloheptane ring.


name: Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Ann Arbor Stage I Supradiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


name: Ann Arbor Stage I Subdiaphragmatic Lymphocyte-Depleted Classic Hodgkin Lymphoma


Diaper candidiasis

description: An inflammatory skin condition in the diaper area superimposed with Candida infection, characterized by a bright red rash with a sharply demarcated edge and satellite lesions. Skin folds are often involved.


Grade 4 Arachnoiditis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Stage IB Adult Soft Tissue Sarcoma AJCC v7


name: Grade 3 Skin Breakdown or Decubitus Ulcer, CTCAE


Grade 3 Anal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 1 Pyramidal Tract Dysfunction, CTCAE


Congenital anomaly of tricuspid valve

description: A defect of the tricuspid valve present at birth.


Midgut Neuroendocrine Tumor G1

description: A neuroendocrine tumor grade 1 that arises from the jejunum, ileum, proximal colon, or appendix.


name: Metastatic Midgut Neuroendocrine Tumor G1

description: A midgut neuroendocrine tumor G1 that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Psoralen and long-wave ultraviolet radiation (PUVA) keratosis

description: A hyperkeratotic skin lesion that occurs in patients with a history of prolonged exposure to psoralen and ultraviolet A (PUVA) therapy.


name: Grade 5 Intestinal Stoma Obstruction, CTCAE

description: Death


name: Grade 3 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


L-mannitol

The L-enantiomer of mannitol.


Oral Cavity Mucosal Melanoma

description: A rare melanoma that arises from the oral cavity. It is associated with a poor prognosis.


Childhood Posterior Fossa Ependymoma

description: A posterior fossa ependymoma that occurs during childhood.


Neonatal Tachyarrhythmia, AE

description: An adverse event in a newborn characterized by non-sinus rhythm with an abnormally high heart rate for age.


Grade 4 Neonatal Tachyarrhythmia, AE

description: A tachyarrhythmia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes.


Grade 5 Neonatal Tachyarrhythmia, AE

description: A tachyarrhythmia adverse event in a newborn which results in death.


Grade 3 Neonatal Tachyarrhythmia, AE

description: A tachyarrhythmia adverse event in a newborn resulting in non-life threatening hemodynamic compromise or changes in age-appropriate behavior; requiring major care changes (e.g. new medication or intervention).


Grade 2 Neonatal Tachyarrhythmia, AE

description: A tachyarrhythmia adverse event in a newborn characterized by no change in age-appropriate behavior; requiring minor care changes (e.g. increased monitoring).


Grade 1 Neonatal Tachyarrhythmia, AE

description: An adverse event in a newborn characterized by brief, self-limiting, episodes of asymptomatic tachyarrhythmia (e.g. extra-systolic beats); no care changes.


Adult Benign Brain Stem Neoplasm

description: A benign neoplasm of the brain stem occurring in adults.


Medullary Hemangioblastoma

description: A hemangioblastoma that arises from the medulla oblongata.


Childhood Brain Stem Gliosarcoma

description: A gliosarcoma that arises from the brain stem and occurs during childhood.


Childhood Brain Stem Mixed Glioma

description: A mixed glioma that arises from the brain stem and occurs during childhood.


name: Metastatic malignant neoplasm to brain stem

description: A malignant neoplasm that has spread from its original site of growth to the brain stem.


Recurrent Childhood Brain Stem Glioma

description: The reemergence of brain stem glioma in childhood after a period of remission.


Anaplastic Brain Stem Astrocytoma

description: An anaplastic astrocytoma that arises from the brain stem.


Brain Stem Glioblastoma

description: A glioblastoma that arises from the brain stem.


Anaplastic Brain Stem Glioma

description: An anaplastic glioma that arises from the brain stem.


name: Grade 5 External Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Recurrent Acute Bilineal Leukemia

description: The reemergence of acute bilineal leukemia after a period of remission.


name: Recurrent Mixed Phenotype Acute Leukemia

description: The reemergence of mixed phenotype acute leukemia after a period of remission.


acute biphenotypic leukemia in relapse

description: The reemergence of acute biphenotypic leukemia after a period of remission.


name: Grade 4 Oral Cavity NOS Intra-Operative Injury, CTCAE


Grade 3 Glaucoma, CTCAE

description: EIOP causing visual field deficits


Grade 4 Hypomagnesemia, CTCAE

description: <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences


name: Ampulla of Vater Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. The Ki-67 index is higher than 20%.


name: Low Risk Small Intestinal Gastrointestinal Stromal Tumor


name: Low Risk Esophageal Gastrointestinal Stromal Tumor


name: Low Risk Colorectal Gastrointestinal Stromal Tumor


name: Low Risk Gastric Gastrointestinal Stromal Tumor


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form thin-branching papillae and exhibit high grade dysplasia.


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that are similar to gastric foveolar epithelial cells.


name: Branch Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

description: An intraductal papillary-mucinous neoplasm of the pancreas that arises in one of the branches of the main pancreatic duct.  It usually has an indolent behavior.


name: Mixed Type Pancreatic Intraductal Papillary-Mucinous Neoplasm

description: An intraductal papillary-mucinous neoplasm of the pancreas that arises primarily from the main pancreatic duct and extends to the branch ducts.


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Oncocytic-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells with abundant eosinophilic granular cytoplasm.


name: Main Duct Pancreatic Intraductal Papillary-Mucinous Neoplasm

description: An intraductal papillary-mucinous neoplasm of the pancreas that arises from the main pancreatic duct.


name: Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type

description: A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form tall papillae, similar to those that are present in colonic villous adenomas.


Advanced Rhabdoid Tumor

description: Rhabdoid tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic Rhabdoid Tumor

description: A rhabdoid tumor that has spread from the original site of growth to another anatomic site.


name: sialadenoma papilliferum of salivary gland

description: An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate.  It is generally asymptomatic.


AURACHIN C

A C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a triprenyl group at position 3.


Elevated Sedimentation Rate

description: A higher than average sedimentation rate in a sample.


name: Low Grade Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is low-grade.


Grade 1 Genital Edema, CTCAE

description: Mild swelling or obscuration of anatomic architecture on close inspection


name: Grade 1 Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia, CTCAE


Tentorial Tear Related to Birth

description: Disruption of the tentorium cerebelli incurred during delivery.


Grade 2 Pericardial Effusion, CTCAE

description: Asymptomatic effusion size small to moderate


name: Classic Hydroa Vacciniforme Lymphoproliferative Disorder

description: Hydroa vacciniforme lymphoproliferative disorder characterized by the presence of self-limited papulovesicular skin lesions in sun-exposed areas. There is no involvement of internal organs. It has an indolent course and usually affects White individuals.


Stage II Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Carsickness

description: A sensation of discomfort associated with ground travel; symptoms may include nausea, vomiting, dizziness or sweating.


name: Grade 1 Appendix Intra-Operative Injury, CTCAE


name: Refractory Paranasal Sinus Squamous Cell Carcinoma

description: Paranasal sinus squamous cell carcinoma that does not respond to treatment.


name: Refractory Head and Neck Squamous Cell Carcinoma

description: A head and neck squamous cell carcinoma that does not respond to treatment.


name: Refractory Sinonasal Squamous Cell Carcinoma

description: Nasal cavity and paranasal sinus squamous cell carcinoma that does not respond to treatment.


name: Refractory Oral Cavity Squamous Cell Carcinoma

description: Oral cavity squamous cell carcinoma that does not respond to treatment.


name: Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that does not respond to treatment.


Hodgkin's lymphoma of small intestine

description: A Hodgkin lymphoma that arises from the small intestine.


name: Resectable Pancreatic Acinar Cell Carcinoma

description: Pancreatic acinar cell carcinoma that is amenable to surgical resection.


Pancreas carcinoma resectable

description: Carcinoma of the pancreas amenable to surgical removal.


name: Borderline Resectable Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma term that refers to a continuum between resectable and locally advanced unresectable disease.


Pancreatic adenocarcinoma resectable

description: Pancreatic adenocarcinoma that is amenable to surgical resection.


name: Resectable Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma amenable to surgical resection.


name: Resectable Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that is amenable to surgical resection.


name: Stage I Lip and Oral Cavity Cancer AJCC v8

description: Stage I includes: T1, N0, M0.  T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less depth of invasion (DOI).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 2 Parotid Gland Intra-Operative Injury, CTCAE


Brain Pilocytic Astrocytoma

description: Pilocytic astrocytoma that arises from the brain.


Third Ventricle Pilocytic Astrocytoma

description: A pilocytic astrocytoma occurring in the third ventricle.


name: Hemolytic anemia due to disseminated intravascular coagulation


Anemia due to membrane defect

description: A group of inherited hemolytic anemias caused by erythrocyte membrane defects. This includes hereditary pyropoikilocytosis, hereditary spherocytosis and hereditary elliptocytosis.


Immune Hemolytic Anemia

description: An acquired anemia resulting from immune-mediated destruction of the red blood cells. Causes include autoimmune disorders, blood transfusions, and drugs.


Infantile pyknocytosis

description: A rare, neonatal syndrome characterized by early jaundice that becomes rapidly associated with severe hemolytic anemia. The peripheral blood smear is remarkable for small irregular, contracted red blood cells with hyper-dense spikes (pyknocytes), that progressively increase in number and then spontaneously disappear.


Refractory Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that is resistant to treatment.


name: Angiocentric immunoproliferative lesion grade 2

description: Lymphomatoid granulomatosis characterized by the presence of occasional large lymphoid cells or immunoblasts in a polymorphous background. Necrosis is more commonly seen as compared to grade I lymphomatoid granulomatosis. By in situ hybridization, EBV-positive cells are readily seen.


name: Central Nervous System Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that affects the brain, spinal cord, and leptomeninges.


Cutaneous Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that affects the skin.


Childhood Lymphomatoid Granulomatosis

description: Lymphomatoid granulomatosis that occurs during childhood.


name: Grade 2 Fallopian Tube Obstruction, CTCAE

description: Symptomatic; elective intervention indicated


Fallopian Tube Obstruction, CTCAE 5.0

description: A disorder characterized by blockage of the normal flow of the contents in the fallopian tube.


name: Grade 1 Fallopian Tube Obstruction, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 3 Fallopian Tube Obstruction, CTCAE

description: Severe symptoms; invasive intervention indicated


name: High Grade Anal Canal Intraepithelial Neoplasia

description: Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit moderate dysplasia (grade II intraepithelial neoplasia) or severe dysplasia (grade III intraepithelial neoplasia or carcinoma in situ).


diphenylethane

Compounds containing two phenyl groups connected by an ethyl linker.


benzoins

An aromatic ketone containing a benzoin (2-hydroxy-1,2-diphenylethanone) skeleton.


name: HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6

description: A lipid transport disorder characterized by extremely elevated levels of high density lipoprotein cholesterol (HDL C; HDLC). It is caused by heterozygous mutations in the SCARB1 gene that result in decreased transport of HCL C into the liver by scavenger receptor class B member 1.


name: Grade 3 Upper Extremity Vein Injury, CTCAE


carbonate ester

Any carbonate that is carbonic acid in which the hydrogens have been replaced by organyl groups.


name: Grade 4 Sinusoidal Obstruction Syndrome, CTCAE

description: Life-threatening consequences (e.g., ventilatory support, dialysis, plasmapheresis, peritoneal drainage)


(S)-salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has S configuration.


(R)-salmeterol

2-(Hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol in which the stereocentre has R configuration.


Refractory Neuroblastoma

description: A neuroblastoma that does not respond to treatment.


name: Reactive Hyperplasia of the Retinal Pigment Epithelium

description: A reactive, non-neoplastic hyperplasia of the retinal pigment epithelium.


name: Grade 3 Neuroendocrine ACTH Deficiency, CTCAE


CPK Increased, CTCAE

description: A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen.


Grade 4 CPK Increased, CTCAE

description: >10 x ULN


Grade 1 CPK Increased, CTCAE

description: >ULN-2.5 x ULN


Grade 2 CPK Increased, CTCAE

description: >2.5 x ULN-5 x ULN


Grade 2 Ovarian Infection, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Grade 5 Cranial Nerve VI Neuropathy, CTCAE


name: Grade 2 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Bone Infection with Unknown Absolute Neutrophil Count, CTCAE


Iris Implantation Cyst

description: A cyst that arises from the iris and is lined by squamous epithelium.


Grade 2 Neonatal Pneumothorax, AE

description: An adverse event in a newborn characterized by radiological evidence of pneumothorax; minor clinical signs; minor care change required (e.g. oxygen, increased monitoring).


carbohydroximic acid

A carboximidic acid having an OH or OR (R = organyl) group attached to the imide nitrogen.


name: Grade 2 Bladder Infection with Unknown Absolute Neutrophil Count, CTCAE


Excessive Bleeding

description: Abnormally heavy or prolonged loss of blood.


Non-toxic multinodular goiter

description: A multinodular goiter that is not associated with changes in thyroid function or malignancy.


Multinodular Endemic Goiter

description: A multinodular goiter caused by inadequate iodine intake.


Adult Leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm, occurring in adults.  It is characterized by a proliferation of neoplastic spindle cells.


Penile Leiomyosarcoma

description: A leiomyosarcoma that occurs in the penis.


Unresectable Leiomyosarcoma

description: A leiomyosarcoma which is not amenable to surgical resection.


Dedifferentiated Leiomyosarcoma

description: A pleomorphic leiomyosarcoma that lacks immunohistochemical staining for myogenic markers in the pleomorphic areas.


name: Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Pancreatic Leiomyosarcoma

description: A rare leiomyosarcoma that arises from the pancreas.


Head and Neck Leiomyosarcoma

description: A malignant neoplasm with smooth muscle differentiation that arises from the head and neck. The most frequently affected sites are the subcutaneous and deep neck soft tissues.


name: Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage I Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IV Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Primary leiomyosarcoma

description: Leiomyosarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


EBV-Related Leiomyosarcoma

description: Leiomyosarcoma that is caused by Epstein-Barr virus infection.


Inferior Vena Cava Leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm, arising from the inferior vena cava.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic leiomyosarcoma

description: A leiomyosarcoma that has spread to other anatomic sites.


leiomyosarcoma of appendix

description: A rare leiomyosarcoma that arises from the appendiceal wall.


Unresectable Soft Tissue Leiomyosarcoma

description: A soft tissue leiomyosarcoma that is not amenable to surgical resection.


name: Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus leiomyosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Conjunctival Leiomyosarcoma

description: A leiomyosarcoma that arises from the conjunctiva.


Seminal Vesicle Leiomyosarcoma

description: A rare leiomyosarcoma that affects the seminal vesicle.


name: Stage IB Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring more than 5 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Pleomorphic leiomyosarcoma

description: A leiomyosarcoma characterized by the presence of poorly differentiated areas with pleomorphic appearance, in addition to areas with typical morphologic features.


Refractory Leiomyosarcoma

description: Leiomyosarcoma that does not respond to treatment.


Leiomyosarcoma of Vessels

description: An aggressive malignant smooth muscle neoplasm, arising from the walls of the vascular system.  It is characterized by a proliferation of neoplastic spindle cells.


leiomyosarcoma of bladder

description: A leiomyosarcoma that arises from the bladder. It is the most common type of bladder sarcoma in adults.


Broad Ligament Leiomyosarcoma

description: A rare leiomyosarcoma that arises from the broad ligament.


name: Unresectable Uterine Corpus Leiomyosarcoma

description: Uterine corpus leiomyosarcoma that is not amenable to surgical resection.


Advanced Soft Tissue Leiomyosarcoma

description: A soft tissue leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Uterine Corpus Leiomyosarcoma by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus leiomyosarcoma according to the American Joint Committee on Cancer, 8th edition.


name: Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Childhood Leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm, occurring in children.  It is characterized by a proliferation of neoplastic spindle cells.


Leiomyosarcoma recurrent

description: The reemergence of leiomyosarcoma after a period of remission


name: Locally Recurrent Uterine Corpus Leiomyosarcoma

description: The reemergence of uterine corpus leiomyosarcoma after a period of remission, at or adjacent to the site of the original tumor.


name: Stage III Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus leiomyosarcoma with tumor limited to the uterus. T2: Uterine corpus leiomyosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus leiomyosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Thyroid Gland Leiomyosarcoma

description: A leiomyosarcoma that arises from the thyroid gland.


name: Metastatic Uterine Corpus Leiomyosarcoma

description: Uterine corpus leiomyosarcoma that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Uterine Corpus Leiomyosarcoma

description: Uterine corpus leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Colorectal Leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm that arises from the colon or rectum.  It is characterized by a proliferation of neoplastic spindle cells.


Metastatic Soft Tissue Leiomyosarcoma

description: A soft tissue leiomyosarcoma that has spread from the original site of growth to another anatomic site.


Sinonasal Leiomyosarcoma

description: A leiomyosarcoma that arises from the nasal cavity and paranasal sinuses.


Well Differentiated Leiomyosarcoma

description: Grade I malignant smooth muscle neoplasm.  It is characterized by a proliferation of neoplastic spindle cells.


name: Stage IA Uterine Corpus Leiomyosarcoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus leiomyosarcoma with tumor limited to the uterus, measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Digestive System Leiomyosarcoma

description: A leiomyosarcoma arising from an anatomic site in the digestive system.


Resectable Leiomyosarcoma

description: Leiomyosarcoma that is amenable to surgical resection.


Advanced Leiomyosarcoma

description: A leiomyosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Locally Advanced Soft Tissue Leiomyosarcoma

description: Soft tissue leiomyosarcoma that has spread to nearby tissues or lymph nodes.


Locally Advanced Leiomyosarcoma

description: A leiomyosarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Leiomyosarcoma of Deep Soft Tissue

description: A rare leiomyosarcoma that arises from the deep soft tissue in the retroperitoneum or abdominal cavity.


name: Grade 4 Skin Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Aortic Injury, CTCAE

description: Operative intervention not indicated


name: Refractory Malignant Soft Tissue Neoplasm

description: Malignant soft tissue neoplasm that is resistant to treatment.


Refractory Extrarenal Rhabdoid Tumor

description: Extrarenal rhabdoid tumor that is  resistant to treatment.


Digestive System Solitary Fibrous Tumor

description: A solitary fibrous tumor arising from an anatomic site in the digestive system, including the esophagus, gallbladder, liver, pancreas, small bowel mesentery, and the serosal surfaces of the stomach and colon.


Skin tumor of smooth muscle origin

description: A smooth muscle neoplasm occurring in the skin.


Pilar Leiomyoma

description: A cutaneous leiomyoma arising from the arrector pili muscle.


Refractory Paraganglioma

description: A paraganglioma that does not respond to treatment.


name: Refractory Adrenal Gland Pheochromocytoma

description: A pheochromocytoma that does not respond to treatment.


Stage IB Uterine Corpus Cancer AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Uterine corpus carcinoma or carcinosarcoma with tumor invading one half or more of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof.


hydroxybenzoic acid

Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring.


3-hydroxyanthranilic acid

An  aminobenzoic acid that is benzoic acid substituted at C-2 by an amine group and at C-3 by a hydroxy group. It is an intermediate in the metabolism of the amino acid tryptophan.


3-amino-5-hydroxybenzoic acid

A monohydroxybenzoic acid that is 3-hydroxybenzoic acid carrying an additional amino substitutent at position 4.


3-amino-4-hydroxybenzoic acid

A monohydroxybenzoic acid that is 4-hydroxybenzoic acid carrying an additional amino substitutent at position 3.


3-amino-2,4-dihydroxybenzoic acid

An aminobenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 4, and by an amino group at position 3.


cannabidiolic acid

A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a 3-p-mentha-1,8-dien-3-yl (limonene) group.


monohydroxybenzoic acid

Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring.


3-hydroxy-4-methylanthranilic acid

An aminobenzoic acid that is anthranilic acid substituted by a hydroxy group at position 3 and a methyl group at position 4.


dihydroxybenzoic acid

Any member of the class of  hydroxybenzoic acids carrying  two phenolic hydroxy groups on the benzene ring and its derivatives.


name: Beta-Catenin-Activated Inflammatory Hepatocellular Adenoma

description: Hepatocellular adenoma with features of both beta-catenin-activated hepatocellular adenoma and inflammatory hepatocellular adenoma.


Grade 3 Nausea, CTCAE

description: Inadequate oral caloric or fluid intake; tube feeding, TPN, or hospitalization indicated


Nausea, CTCAE 5.0

description: A disorder characterized by a queasy sensation and/or the urge to vomit.


Grade 2 Nausea, CTCAE

description: Oral intake decreased without significant weight loss, dehydration or malnutrition


Grade 1 Nausea, CTCAE

description: Loss of appetite without alteration in eating habits


name: Grade 3 Infusion Site Extravasation, CTCAE

description: Ulceration or necrosis; severe tissue damage; operative intervention indicated


Acute esophagitis

description: An acute inflammatory process affecting the esophageal wall.


Precocious Puberty, CTCAE 5.0

description: A disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys.


Grade 2 Precocious Puberty, CTCAE

description: Physical signs and biochemical markers of puberty for females <8 years and males <9 years


Grade 1 Precocious Puberty, CTCAE

description: Physical signs of puberty with no biochemical markers for females <8 years and males <9 years


Refractory Rhabdoid Tumor of the Kidney

description: A rhabdoid tumor of the kidney that does not respond to treatment.


Recurrent Rhabdoid Tumor of the Kidney

description: The reemergence of a rhabdoid tumor of the kidney after a period of remission.


name: Unresectable Rhabdoid Tumor of the Kidney

description: Rhabdoid tumor of the kidney that is not amenable to surgical resection.


Gastrointestinal stromal tumor, benign

description: A gastrointestinal stromal tumor that is characterized by a maximum diameter equal or less than 5 cm (gastric localization), or equal or less than 2 cm (intestinal localization) and no more than 5 mitotic figures per 50 high power fields.


name: Benign Gastric Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor arising from the stomach.  It is characterized by a maximum diameter equal or less than 5 cm and no more than 5 mitotic figures per 50 high power fields.


name: Stage IA Hepatocellular Carcinoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Solitary tumor equal to or less than 2 cm.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage I Hepatocellular Carcinoma AJCC v8

description: Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0). T1a: Solitary tumor equal to or less than 2 cm.  T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IB Hepatocellular Carcinoma AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Solitary tumor larger than 2 cm without vascular invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Grade 3 Atelectasis, CTCAE

description: Supplemental oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser)


inorganic potassium salt

A potassium salt that lacks C-H bonds


potassium salt

Any alkali metal salt having potassium(1+) as the cation.


Breast Myoid Hamartoma

description: A breast hamartoma characterized by the predominance of a smooth muscle component.


name: Grade 2 Dental and Teeth and Peridontal Pain, CTCAE


Grade 2 Dehydration, CTCAE

description: IV fluids indicated


Dehydration, CTCAE

description: A disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis.


Grade 5 Dehydration, CTCAE

description: Death


Grade 4 Dehydration, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Dehydration, CTCAE

description: Increased oral fluids indicated; dry mucous membranes; diminished skin turgor


Grade 3 Dehydration, CTCAE

description: Hospitalization indicated


name: Grade 5 Abdomen Soft Tissue Necrosis, CTCAE


name: Colorectal Microvesicular Hyperplastic Polyp

description: A serrated hyperplastic polyp that arises from the colon and rectum.  It is characterized by the presence of microvacuolated columnar cells that are admixed with small numbers of goblet cells.  There is no evidence of epithelial atypia or dysplasia.


Refractory Visual Pathway Glioma

description: Visual pathway glioma that is resistant to treatment.


name: Stage II Gastric Neuroendocrine Tumor AJCC v8

description: Stage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Dysembryoplastic Neuroepithelial-Like Tumor of the Septum Pellucidum

description: A very rare, low-grade midline brain neoplasm that affects the septum pellucidum. It is characterized by similar histological features to those found in dysembryoplastic neuroepithelial tumor, but does not display multinodularity. It usually manifests with symptoms related to increased intracranial pressure. Epilepsy has been reported in approximately one third of patients. PDGFRA gene mutations have been identified in the majority of patients. Alterations in FGFR1 and NF1 genes have also been reported. BRAF mutations which represent the most common molecular alteration found in cortical dysembryoplastic neuroepithelial tumor, were absent in this rare group of midline tumors.


Childhood Parathyroid Gland Adenoma

description: An adenoma of the parathyroid gland that occurs during childhood.


Parathyroid Gland Lipoadenoma

description: A parathyroid gland adenoma that contains mature adipocytes.


name: Stage IV Childhood Retinoblastoma by Toronto Guidelines v2

description: Distant metastatic disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 2 Gingiva Intra-Operative Injury, CTCAE


name: Grade 4 Treatment Related Secondary Malignancy, CTCAE

description: Acute life-threatening secondary malignancy; blast crisis in leukemia


Thyroid Gland Cavernous Hemangioma

description: A rare cavernous hemangioma that arises from the thyroid gland.


Benign Thyroid Gland Vascular Neoplasm

description: A rare benign vascular neoplasm that arises from the thyroid gland. This category includes hemangiomas, cavernous hemangiomas, and lymphangiomas.


Thyroid Gland Hemangioma

description: A rare hemangioma that arises from the thyroid gland.


Thyroid Gland Lymphangioma

description: An extremely rare lymphangioma that arises from the thyroid gland.


Grade 5 Vasovagal Reaction, CTCAE

description: Death


Stage IIIB Cervical Cancer AJCC v8

description: Stage IIIB includes: T3b, Any N, M0. T3b: extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


Grade 5 Lung Infection, CTCAE

description: Death


name: Peritoneal mesothelioma malignant recurrent

description: The reemergence of malignant peritoneal mesothelioma after a period of remission.


Mesothelioma malignant recurrent

description: The reemergence of malignant mesothelioma after a period of remission


Grade 5 Edema Cerebral, CTCAE

description: Death


name: Grade 3 Atrial Tachycardia or Paroxysmal Atrial Tachycardia, CTCAE


Thoracic Esophagus Adenocarcinoma

description: An adenocarcinoma that arises from the thoracic esophagus.


name: Grade 5 Brain Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Fundic gland polyp

description: The most common gastric polyp in the Western hemisphere.  The lesion consists of a localized hyperplasia of the deep epithelial compartment of the oxyntic mucosa, with variable degrees of cystic dilatation.  Malignant transformation is the exception.  (WHO, 2000)


name: Grade 1 Pharynx Obstruction and Stenosis, CTCAE


Stage II Rectosigmoid Cancer AJCC v7

description: Stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues.  T4a: Tumor penetrates to the surface of the visceral peritoneum.  T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Grade 2 Abducens Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


DL-PHENYLALANINE

An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.


name: Clinical Stage 0 Merkel Cell Carcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: In situ primary tumor. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Merkel Cell Carcinoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


name: Clinical Stage IV Merkel Cell Carcinoma AJCC v8

description: Stage IV includes: T0-4, Any N, M1. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. M1: Distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Clinical Stage IIA Merkel Cell Carcinoma AJCC v8

description: Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Clinical Stage IIB Merkel Cell Carcinoma AJCC v8

description: Stage IIB includes: T4, N0, M0. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Clinical Stage II Merkel Cell Carcinoma AJCC v8

description: Stage II includes: IIA: (T2-3, N0, M0); IIB: (T4, N0, M0). T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Clinical Stage III Merkel Cell Carcinoma AJCC v8

description: Stage III includes: T0-4, N1-3, M0. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1: Metastasis in regional lymph node(s). N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Clinical Stage I Merkel Cell Carcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. N0: No regional lymph node metastasis detected on clinical and/or radiologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Small Intestinal Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


name: Small Intestinal Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the small intestine.  It is characterized by the presence of malignant large cells.


Recurrent Rectal Cancer

description: The reemergence of rectal carcinoma after a period of remission.


Rectal adenocarcinoma recurrent

description: The reemergence of rectal adenocarcinoma after a period of remission.


Radiating Chest Pain in Abdomen

description: The location of the radiating chest pain is in the abdomen.


name: Hemoglobin Increase Greater than or Equal to 1.5 g/dL

description: A semiquantitative finding indicating that the concentration of hemoglobin has increased by at least 1.5 g/dL compared to the value recorded for a previous sample from that subject.


polyatomic cation

A cation consisting of more than one atom.


phosphocholines

Any compound having phosphocholine as part of its structure.


phosphatidylcholine

A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.


The conjugate base of a 1,2-diacyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group.


An ammonium ion that is the conjugate acid of pyridoxamine arising from selective protonation of the primary amino group; major species at pH 7.3.


(S)-bethanechol

The (S)-enantiomer of bethanechol.


A 1,2-diacyl-sn-glycero-3-phosphocholine where the acyl group at position 1 is unspecified while the acyl group at position 2 is palmitoyl.


glycerophosphocholine

The glycerol phosphate ester of a phosphocholine. A nutrient with many different roles in human health.


A phosphatidylcholine 36:3 in which the acyl groups specified at positions 1 and 2 are octadecanoyl and (6Z,9Z,12Z)-octadecatrienoyl respectively.


ammonium ion derivative

A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).


phosphatidylcholine 32:0

A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 32 carbons in total with 0 double bonds.


A primary ammonium ion that is the conjugate acid of thiamine(1+) resulting from the protonation of the primary amino group.


(R)-bethanechol

The (R)-enantiomer of bethanechol.


acylcholine

A choline ester formed from choline and a carboxylic acid.


cholines

A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof.


quaternary ammonium ion

A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.


name: Lumbar Spine Joint Range of Motion Decreased

description: Decreased flexibility of a lumbar spine joint.


Stage IIIB Cervical Cancer FIGO 2018

description: Cervical carcinoma with extension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). (FIGO 2018)


name: Grade 5 Pharynx Stricture or Stenosis, CTCAE


name: Grade 4 Pharynx Stricture or Stenosis, CTCAE


name: Grade 1 Pharynx Stricture or Stenosis, CTCAE


name: Grade 3 Pharynx Stricture or Stenosis, CTCAE


name: Grade 2 Pharynx Stricture or Stenosis, CTCAE


Leaflet Disruption Due To Calcification

description: The disturbance of a cusp of a heart valve secondary to the accumulation of calcium on the valve tissue. This most often results in stenosis of the valve.


Leaflet Disruption

description: The disturbance of a cusp of a heart valve, often resutling in dysfunction of the valve.


Leaflet Disruption Due To Infection

description: The disturbance of a cusp of a heart valve secondary to infection affecting the valve tissue, which can result in valvular dysfunction.


Leaflet Disruption Due To Unknown Cause

description: The disturbance of a cusp of a heart valve without an identifiable cause.


name: Leaflet Disruption Due To Host Tissue Overgrowth

description: The disturbance of a cusp of a heart valve secondary to an increase in tissue mass at the valve site, which can lead to valve dysfunction. This often happens as a result of fibrosis of tissue surrounding the suture line of a prosthetic valve.


name: Leaflet Disruption Due To Suture Abrasion

description: The disturbance of a cusp of a heart valve secondary to irritation by surgical sutures, which can result in valvular dysfunction.


Vulvar Fibroadenoma

description: A benign epithelial-stromal neoplasm that arises from the vulva and resembles the breast fibroadenoma.


name: Fibroadenoma of Anogenital Mammary-Type Glands

description: A benign epithelial-stromal neoplasm that arises from the perineum and resembles the breast fibroadenoma.


Anal Fibroadenoma

description: A benign epithelial-stromal neoplasm that arises from the anus and resembles the breast fibroadenoma.


name: Esophageal Squamous Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal squamous epithelium.


name: High Grade Esophageal Squamous Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal squamous epithelium.


name: Low Grade Esophageal Squamous Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal squamous epithelium.


name: Extramedullary Disease in Multiple Myeloma Involving the Liver

description: Infiltration of the hepatic sinusoids by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Grade 4 Cecal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Urostomy Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Grade 3 Lipohypertrophy, CTCAE

description: Covering >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL


name: Unresectable Diffuse Midline Glioma, H3 K27M-Mutant

description: Diffuse midline glioma, H3 K27M-mutant that is not amenable to surgical resection.


Unresectable Diffuse Midline Glioma

description: Diffuse midline glioma that is not amenable to surgical resection.


Percentage Body Weight Gain

description: The amount of weight gained over a period of time in relation to the total weight.


A secondary amino compound that is ammonia in which nitrogen is substituted by a 1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl group and a 2-(2-ethoxyphenoxy)ethyl group.


name: Stage IIIA Gastric Gastrointestinal Stromal Tumor

description: Stage IIIA includes: T3, N0, M0, Mitotic rate: High. T3: Tumor more than 5 cm, but not more than 10 cm, in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


sulfate

A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.


name: Long-Term Effects Secondary to Cancer Therapy in Adults

description: Side effects of cancer treatment received during adulthood occurring a long time after the treatment was completed.


Hemangioendothelioma, benign

description: A benign vascular proliferation characterized by the presence of prominent endothelial cells and the formation of vascular channels.


Grade 3 Mania, CTCAE

description: Severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated; new onset


Mania, CTCAE

description: A disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood.


Grade 4 Mania, CTCAE

description: Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Grade 2 Mania, CTCAE

description: Moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene)


Grade 1 Mania, CTCAE

description: Mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep)


Grade 5 Mania, CTCAE

description: Death


name: Stage IIIA Rectal Neuroendocrine Tumor AJCC v8

description: Stage IIIA includes: T4, N0, M0. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Colorectal Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a colorectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to colorectal "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the colon and rectum are not staged using this staging system. (from AJCC 8th Ed.)


name: Stage I Colorectal Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIB Colon Neuroendocrine Tumor AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIB Rectal Neuroendocrine Tumor AJCC v8


name: Stage IIIB Colon Neuroendocrine Tumor AJCC v8

description: Stage IIIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIIB Rectal Neuroendocrine Tumor AJCC v8


name: Rectal Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a rectal neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to rectal "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the rectum are not staged using this staging system. (from AJCC 8th Ed.)


name: Stage IIB Colorectal Neuroendocrine Tumor AJCC v8


name: Stage IIA Colorectal Neuroendocrine Tumor AJCC v8

description: Stage IIA includes: T2, N0, M0. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIA Rectal Neuroendocrine Tumor AJCC v8


name: Colon Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a colon neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to colon "carcinoid" tumors (neuroendocrine tumor G1 and G2, and rare-well differentiated G3). High-grade neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas of the colon are not staged using this staging system. (from AJCC 8th Ed.)


name: Stage IIIB Colorectal Neuroendocrine Tumor AJCC v8


name: Stage I Colon Neuroendocrine Tumor AJCC v8


name: Stage IIIA Colon Neuroendocrine Tumor AJCC v8


name: Stage IIA Colon Neuroendocrine Tumor AJCC v8


name: Stage IIIA Colorectal Neuroendocrine Tumor AJCC v8


name: Grade 1 Cardiac Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Cardiac Disorders - Other, Specify, CTCAE


name: Grade 2 Cardiac Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Grade 5 Cardiac Disorders - Other, Specify, CTCAE

description: Death


name: Grade 3 Cardiac Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


name: Grade 4 Cardiac Disorders - Other, Specify, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Head and Neck Phosphaturic Mesenchymal Tumor

description: A phosphaturic mesenchymal tumor that arises from the head and neck. It usually affects the paranasal sinuses. The head and neck region is the most frequently involved site for phosphaturic mesenchymal tumors, following the appendicular skeleton.


name: Appendicular Skeleton Phosphaturic Mesenchymal Tumor

description: A phosphaturic mesenchymal tumor that arises from the appendicular skeleton. The appendicular skeleton is the most frequently involved site for phosphaturic mesenchymal tumors.


name: Malignant phosphaturic mesenchymal tumor

description: A phosphaturic mesenchymal tumor characterized by the presence of nuclear atypia, high mitotic activity, increased cellularity, marked pleomorphism, and necrosis. It usually develops in lesions that have recurred locally and metastasizes to other sites.


name: Metastatic malignant neoplasm to trachea

description: A malignant neoplasm that has spread to the trachea from another anatomic site.


Grade 1 Ejaculation Disorder, CTCAE

description: Diminished ejaculation


Ejaculation Disorder, CTCAE

description: A disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.


Grade 2 Ejaculation Disorder, CTCAE

description: Anejaculation or retrograde ejaculation


name: Grade 4 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Bilateral Synchronous Sporadic Renal Cell Carcinoma

description: Non-hereditary renal cell carcinoma arising from a kidney and detected in the other kidney within six months of the first primary. The majority are clear cell renal cell carcinomas.


Kidney Germ Cell Tumor

description: A rare benign or malignant germ cell tumor that arises from the kidney.


Grade 3 Sinus Pain, CTCAE

description: Severe pain; limiting self care ADL


paraben

A 4-hydroxybenzoate ester in which the esterifying alcohol is an alkanol (in diagram, R = alkyl). Commonly used as preservatives in cosmetic and pharmaceutical products.


Arteriovenous graft thrombosis

description: Partial or complete occlusion of the lumen of an arteriovenous graft by a thrombus.


Grade 5 Epistaxis, CTCAE

description: Death


Grade 3 Trismus, CTCAE

description: Decreased ROM with inability to adequately aliment or hydrate orally


name: Refractory Childhood Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that occurs in childhood and does not respond to treatment.


Childhood Acute Basophilic Leukemia

description: An acute basophilic leukemia occurring in children.


Sinonasal Solitary Fibrous Tumor

description: A solitary fibrous tumor that arises from the nasal cavity and paranasal sinuses.


Supernumerary Hemivertebra

description: More than the usual or expected number of hemivertebra.


name: Malignant neoplasm of hypopharynx recurrent

description: The reemergence of a hypopharyngeal malignant neoplasm after a period of remission.


Benign neoplasm of pyriform sinus

description: A neoplasm that arises from the pyriform sinus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Neoplasm of pyriform sinus

description: A benign or malignant neoplasm that affects the pyriform sinus.


COVID-19-Associated Anosmia

description: Anosmia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Grade 3 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Appendix Infection with Unknown Absolute Neutrophil Count, CTCAE


Tentorial tear due to birth trauma

description: Pertaining to tears involving the tentorium of the cerebellum.


name: Grade 4 Stoma Pulmonary Hemorrhage, CTCAE


Resectable Carcinoma

description: Carcinoma that is amenable to surgical resection.


name: Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

description: Cutaneous squamous cell carcinoma of the head and neck that is amenable to surgical resection.


Resectable Periampullary Adenocarcinoma

description: Periampullary adenocarcinoma that is amenable to surgical removal.


name: Resectable Liver and Intrahepatic Bile Duct Carcinoma

description: Liver carcinoma that is amenable to surgical resection.


Resectable Merkel Cell Carcinoma

description: Merkel cell carcinoma that is amenable to surgical resection.


Resectable Digestive System Carcinoma

description: Digestive system carcinoma that is amenable to surgical resection.


Resectable Skin Squamous Cell Carcinoma

description: Skin squamous cell carcinoma that is amenable to surgical resection.


name: Localized Resectable Adult Liver Carcinoma

description: A localized hepatocellular carcinoma or intrahepatic cholangiocarcinoma that occurs during adulthood and it is amenable to surgical resection.


name: Resectable Head and Neck Squamous Cell Carcinoma

description: Squamous cell carcinoma of the head and neck which is amendable to surgical removal.


name: Resectable Ampulla of Vater Adenocarcinoma

description: Ampulla of Vater adenocarcinoma that is amenable to surgical resection.


Resectable Appendix Carcinoma

description: Appendix carcinoma that is amenable to surgical resection.


Resectable Gastric Adenocarcinoma

description: Gastric adenocarcinoma that is amenable to surgical resection.


Resectable Endometrial Carcinoma

description: Endometrial carcinoma that is amenable to surgical resection.


Resectable Skin Carcinoma

description: Skin carcinoma that is amenable to surgical resection.


Small intestine carcinoma resectable

description: Carcinoma of the small intestine amendable to resection.


Resectable Colon Carcinoma

description: Colon carcinoma that is amenable to surgical resection.


Resectable Esophageal Carcinoma

description: Esophageal carcinoma that is amenable to surgical resection.


Resectable Gallbladder Adenocarcinoma

description: Gallbladder adenocarcinoma that is amenable to surgical resection.


name: Localized Resectable Adult Hepatocellular Carcinoma

description: A localized hepatocellular carcinoma that occurs during adulthood and it is amenable to surgical resection.


name: Resectable Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that is amenable to surgical resection.


Resectable Cervical Carcinoma

description: Cervical carcinoma that is amenable to surgical resection.


Carcinoma duodenum resectable

description: Carcinoma of the duodenum amendable to surgical removal.


Resectable Colorectal Carcinoma

description: Colorectal carcinoma that is amenable to surgical resection.


Carcinoma liver resectable

description: A hepatocellular carcinoma that is amenable to surgical resection.


Resectable Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that is amenable to surgical resection.


Resectable Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that is amenable to surgical resection.


Grade 1 Scalp Pain, CTCAE

description: Mild pain


name: Childhood Cerebellar Anaplastic Astrocytoma

description: A cerebellar anaplastic astrocytoma that occurs during childhood.


name: Grade 2 Oral Cavity Pulmonary Fistula, CTCAE


Stage II Lip Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Lower Gingival Verrucous Carcinoma

description: A verrucous carcinoma of the oral cavity that arises from the lower gingiva.


name: Verrucous carcinoma of the oral cavity recurrent

description: Reemergence of verrucous carcinoma of the oral cavity after a period of remission.


Tongue Verrucous Carcinoma

description: A well differentiated squamous cell carcinoma arising from the tongue.  It is an exophytic, warty, slow growing tumor, usually affecting older males. It is associated with the chronic use of smokeless tobacco.


Buccal Mucosa Verrucous Carcinoma

description: A verrucous carcinoma of the oral cavity that arises from the buccal mucosa.


Oral Cavity Carcinoma Cuniculatum

description: A variant of well-differentiated squamous cell carcinoma arising from the oral cavity. It is characterized by the presence of minimal cytological atypia, multiple keratin-filled crypts, and intraepithelial neutrophils.


Upper Gingival Verrucous Carcinoma

description: A verrucous carcinoma of the oral cavity that arises from the upper gingiva.


Positive Laboratory Test Result

description: A laboratory test result that indicates that a specific disease, condition, or attribute being assessed is present.


Human Immunodeficiency Virus 1 Positive

description: Indicates that human immunodeficiency virus 1 has been detected in a sample.


Disseminated Tumor Cells Positive

description: An indication that single tumor cells or small clusters of tumor cells have been detected in a tissue sample.


Monoclonal Band

description: Monoclonal immunoglobulin or monoclonal light chain that is present in the serum and/or urine. It is the result of a clonal B-cell or plasma cell proliferation.


Hormone Receptor Positive

description: A finding indicating that the neoplastic cells in a tissue sample test positive for hormone receptors.


Expression Positive

description: An indication that the expression of a gene, transcript or protein has been detected in a sample.


Rearrangement Detected

description: An indication that a cytogenetic rearrangement was detected in a sample.


Refractory Hairy Cell Leukemia Variant

description: Hairy cell leukemia variant that is resistant to treatment.


name: HHV-8-Associated Multicentric Castleman Disease

description: Multicentric Castleman disease associated with HHV8 infection.


Sellar Chondroid Chordoma

description: A chondroid chordoma that arises from the sellar region.


Conventional Chordoma

description: A malignant bone tumor arising from the remnants of the fetal notochord. It is characterized by the presence of large epithelioid cells with clear to light eosinophilic cytoplasm. Some of the cells are large with bubbly, vacuolated cytoplasm (physaliphorous cells). The cells form cords and nests that are embedded within an extracellular myxoid matrix.


Grade 1 Abducens Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


description: An adenocarcinoma that arises from the sinonasal tract. It is characterized by the absence of features that resemble intestinal adenocarcinoma.


Recurrent Malignant Mastocytosis

description: The reemergence of malignant mastocytosis after a period of remission.


Recurrent Mast Cell Leukemia

description: The reemergence of mast cell leukemia after a period of remission.


name: Psychogenic Musculoskeletal Chest Pain with Dysfunctional Breathing

description: A condition in which there is musculoskeletal chest pain associated with inappropriate hyperpnea or tachypnea. (ACC/AHA)


Psychogenic Musculoskeletal Chest Pain

description: A condition in which there is the sensation of musculoskeletal chest pain due to a conversion disorder. (ACC/AHA)


Sellar Gangliocytoma

description: A tumor that arises in the sellar region and is characterized by the presence of mature ganglion cells and neuronal differentiation. It is often associated with the presence of pituitary neuroendocrine tumors/adenomas.


Double-Negative Prostate Carcinoma

description: A metastatic, castration-resistant prostate carcinoma that is composed of fibroblast growth factor-driven malignant cells.


name: Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents

description: Castration-resistant prostate carcinoma which is refractory to second-generation androgen receptor axis-targeted agents, namely abiraterone and enzalutamide.


name: Intermediate Atypical Prostate Carcinoma

description: An aggressive, castration-resistant, histologically distinct, metastatic carcinoma arising from the prostate gland. It is characterized by the presence of a pure population of cytologically bland malignant epithelial cells with moderate to abundant cytoplasm and rare mitotic figures. The prognosis is poor.


Aggressive Variant Prostate Carcinoma

description: A lethal form of advanced castration-resistant prostate carcinoma that emerges in the later stages of castration-resistant treatment. It is an adaptive response to androgen receptor pathway inhibition. The morphologic features vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small cell carcinomas to pure small cell carcinomas expressing neuroendocrine markers. Clinically, it manifests with rapidly progressive disease, visceral or lytic bone metastases and bulky tumor masses. Molecular studies have shown the loss of tumor suppressor genes TP53 and RB1.


Grade 4 Pericardial Effusion, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Advanced Unfavorable Hodgkin Lymphoma

description: An advanced Hodgkin lymphoma with unfavorable prognosis.


allylamine antifungal drug

An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug.


Situs inversus thoracis

description: A congenital condition in which there is complete right-to-left reversal of the position of the thoracic organs.


Urethritis Glandularis

description: A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by metaplastic glandular cells.


magnesium oxide nanocrystal

A nanocrystal composed of magnesium oxide.


Dialysis Catheter Tunnel Infection

description: Local infection involving the subcutaneously tunneled portion of a dialysis catheter.


Grade 4 Stevens-Johnson Syndrome, CTCAE

description: Skin sloughing covering 10-30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment)


name: Grade 4 Gastrointestinal Stoma Hemorrhage, CTCAE


name: Oncocytic Variant of Chromophobe Renal Cell Carcinoma

description: A rare variant of chromophobe renal cell carcinoma that exhibits oncocytoma-like features.


name: Lugano Classification Stage IV Adult Hodgkin Lymphoma AJCC v8

description: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


name: Lugano Classification Stage IV Adult Lymphoma AJCC v8