name: Gelatinous transformation of the bone marrow

description: A rare condition characterized by bone marrow fat cell atrophy, loss of hematopoietic cells, and bone marrow deposition of extracellular gelatinous substances containing mucopolysaccharides rich in hyaluronic acid. The pathogenesis is unknown. It presents with weight loss and anemia. It has been associated with infections, alcoholism, anorexia nervosa, cachexia, end stage renal disease, and cancers.


name: Grade 5 Non-Malignant Pericardial Effusion, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Grade 1 Brachial Plexopathy, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 5 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Grade 2 Restlessness, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Immune Related Adverse Event

description: An adverse event affecting the immune system.


name: Grade 3 Thrombotic Microangiopathy, CTCAE


Ear Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the ear.


Breast Ductal Hyperplasia

description: Hyperplasia of the epithelial cells in the breast ducts. It includes the atypical ductal hyperplasia, papillary intraductal hyperplasia, intraductal myoepitheliosis, and ductal hyperplasia of the usual type.


Grade 3 Peritoneal Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Neonatal Epileptic Seizure, AE

description: An adverse event in a newborn characterized by a single, self-limited electroencephalogram (EEG)-proven seizure requiring no treatment.


Secondary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that occurs in response to physiological stimuli (e.g., vitamin D deficiency, hyperphosphatemia, and hypocalcemia).


High Calcium Level

description: A higher than average level of calcium in a sample.


name: Metastatic Malignant Female Reproductive System Neoplasm

description: A malignant neoplasm that arises in the female reproductive system and has spread from its original site of growth to other anatomic sites.


Gastric Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the stomach. The Ki-67 index is higher than 20%.


name: Grade 5 Abdomen Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Small Bowel Stricture or Stenosis NOS, CTCAE


Locally Advanced Esophageal Carcinoma

description: Esophageal carcinoma that has spread to nearby tissues or lymph nodes.


Childhood Anaplastic Ependymoma

description: An anaplastic ependymoma that occurs during childhood.


Grade 4 Vaginal Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Tumor of the Thecoma/Fibroma Group

description: A sex cord-stromal tumor that arises from the ovary or the testis. Representative examples include fibroma, fibrosarcoma, and thecoma.


Grade 4 Wound Complication, CTCAE

description: Life-threatening consequences


name: Grade 3 Urinary Tract Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Testes Stricture or Stenosis, CTCAE


Fat adherence syndrome

description: Violation of Tenon's capsule with prolapse of orbital fat into the sub-Tenon's space.


Stage I Cutaneous Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Grade 2 Spasticity, CTCAE

description: Moderate increase in muscle tone and increase in resistance through range of motion


name: Locally Advanced Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Advanced Non-Functioning Neuroendocrine Tumor

description: A non-functioning neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Urethrotrigonitis

description: Inflammation of both the urethra and the trigone of the urinary bladder.


Apnea, CTCAE

description: A disorder characterized by cessation of breathing.


name: Lugano Classification Stage III Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Stage III Ureter Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 1 Jugular Vein Intra-Operative Injury, CTCAE


Obstruction Gastric, CTCAE

description: A disorder characterized by blockage of the normal flow of the contents in the stomach.


Grade 4 Hypertension, CTCAE

description: Adult and Pediatric: Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated


Grade 5 Scrotal Infection, CTCAE

description: Death


Injury of diaphragm

description: Trauma to the thoracic diaphragm.


name: Grade 5 Esophageal Anastomotic Leak, CTCAE

description: Death


Dyspnea with Mild Physical Activity

description: Dyspnea experienced during minimal exertion.


Meningioangiomatosis

description: A rare vascular malformation in the cerebral cortex and overlying leptomeninges.  It can occur sporadically or in association with neurofibromatosis type 2.


Grade 3 Delusions, CTCAE

description: Severe delusional symptoms; hospitalization not indicated; new onset


Grade 1 Alkalosis, CTCAE

description: pH >normal, but <=7.5


Unresectable Lymphoma

description: Lymphoma that is not amenable to surgical resection.


name: Grade 2 Infusion Related Reaction, CTCAE

description: Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs


Refractory Solitary Fibrous Tumor

description: Solitary fibrous tumor that is resistant to treatment.


Grade 5 Ileal Ulcer, CTCAE

description: Death


Central Osteoma

description: An osteoma that arises from the endosteum.


name: Grade 3 Other Metabolic and Laboratory, CTCAE


name: EBV-Positive Polymorphic B-Cell Lymphoproliferative Disorder, Not Otherwise Specified

description: An EBV-positive B-cell lymphoproliferative disorder characterized by altered tissue architecture and a polymorphic infiltrate that does not fulfill the criteria for the diagnosis of lymphoma and cannot be precisely categorized.


name: Deletion of the Short Arm of Chromosome 1 (1p) Associated Meningioma

description: A meningioma that is associated with deletion of chromosomal arm 1p.


Grade 2 INR Increased, CTCAE

description: >1.5-2.5; >1.5-2.5 x baseline if on anticoagulation; dose adjustment indicated


Cockade nevus

description: A rare speckled nevus with concentric pattern of pigmentation and central papule surrounded by clear zone.


Localized Malignant Brain Neoplasm

description: A malignant brain neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


name: Heart Infection with Unknown Absolute Neutrophil Count, CTCAE


DDIT4L Acute Lymphoblastic Leukemia

description: A gene expression subtype of acute lymphoblastic leukemia characterized by its expression level of the DDIT4L gene.


Grade 1 Gastric Fistula, CTCAE

description: Asymptomatic


name: Childhood Peripheral Nervous System Neoplasm

description: A neoplasm that affects the peripheral nervous system during childhood.


Drug/Toxin-Induced Aplastic Anemia

description: Bone marrow failure defined as pancytopenia, due to exposure to a known toxin or drug.


name: Grade 2 Nasal Cavity Intra-Operative Injury, CTCAE


name: Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8

description: A monotypic HHV8-positive lymphoproliferative disorder that usually occurs in HIV-negative individuals. It is characterized by the presence of HHV8-positive plasmablasts partially or completely replacing germinal centers. Coinfection with EBV is characteristic. In most cases, there is a favorable response to chemotherapy or radiation. (WHO 2017)


Unresectable Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is not amenable to surgical resection.


Childhood Spitz Nevus

description: A Spitz nevus that occurs during childhood.


name: Grade 3 Face NOS Intra-Operative Injury, CTCAE


description: An alveolar rhabdomyosarcoma characterized by the presence of chromosomal translocation t(1;13)(p36;q14) that results in PAX7-FOXO1 gene fusion; or translocation t(2;13)(q35;q14) that results in PAX3-FOXO1 gene fusion.  Approximately 80% of alveolar rhabdomyosarcomas are fusion-positive.


name: AIDS-Related Diffuse Mixed Cell Lymphoma

description: A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of a mixture of lymphocytes of various sizes.


name: Grade 2 Eye Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL; best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline


name: Vaginal Small Cell Neuroendocrine Carcinoma

description: A rare small cell neuroendocrine carcinoma that arises from the vagina.


Hyperphosphatemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of phosphate in a blood.


Grade 2 Hearing Impaired, CTCAE

description: Adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift of >25 dB averaged at 2 contiguous test frequencies in at least one ear; Adults not enrolled on a Monitoring Program: Hearing loss with hearing aid or intervention not indicated; limiting instrumental ADL; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift >20 dB at 4 kHz in at least one ear


Grade 3 Hypothermia, CTCAE

description: 32->28 degrees C; 89.6->82.4 degrees F


name: Grade 2 Ovary Intra-Operative Injury, CTCAE


Vulvar Cancer by AJCC v6 Stage

description: A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 6th edition.


Adnexal Cribriform Carcinoma

description: A rare indolent adnexal carcinoma with a cribriform pattern.


name: Grade 5 Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Pancreatic Poorly Cohesive Adenocarcinoma

description: An adenocarcinoma that arises from the pancreas and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 7

description: Dyskeratosis congenita caused by mutation(s) in the ACD gene, encoding adrenocortical dysplasia protein homolog.


Columnar Cell Change of the Breast

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Apical cytoplasmic snouts may be present, but they are not prominent.  Secretions may be present in the lumina of the dilated acini.


name: Locally Advanced Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread from its original site of growth to nearby tissues or lymph nodes.


Memory Impairment, CTCAE 5.0

description: A disorder characterized by a deterioration in memory function.


name: Recurrent Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial endometrioid adenocarcinoma after a period of remission.


Appendix Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 7th edition. Carcinoid tumors are staged separately. (from AJCC 7th Ed.)


Persistent Adverse Event

description: An adverse event that extends continuously, without resolution between treatment cycles or courses.


Epistaxis, CTCAE

description: A disorder characterized by bleeding from the nose.


Grade 1 Stroke, CTCAE

description: Incidental radiographic findings only


Extra Lumbar Vertebra

description: A congenital anomaly of the spine, where an extra or supernumerary lumbar vertebra arises from below the 5th lumbar vertebra.


Grade 4 Obesity, CTCAE

description: BMI >=40 kg/m2


Stage IB1 Cervical Cancer

description: Stage IB1 includes: T1b1, N0, M0.  T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Bone Cancer AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Deficiency of reductase

description: A deficiency in an enzyme that promotes reduction of an organic compound.


name: Grade 4 Cytomegalovirus Infection Reactivation, CTCAE

description: Life-threatening consequences; urgent intervention indicated; blindness


name: Grade 1 Arachnoiditis and Meningismus and Radiculitis, CTCAE


name: Grade 5 Esophageal Varices Hemorrhage, CTCAE

description: Death


name: Grade 3 Recurrent Laryngeal Nerve Palsy, CTCAE

description: Severe symptoms; medical intervention indicated (e.g., thyroplasty, vocal cord injection)


name: Salivary Gland Intra-Operative Injury, CTCAE


name: Grade 3 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor


description: Transient hyperinsulinism that occurs in response to neonatal stress resulting in prolonged neonatal hypoglycemia, which is distinct from transitional hypoglycemia of typical infants.


name: Grade 5 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

description: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic/myeloproliferative neoplasm.


Neonatal Sinus Bradycardia, AE

description: An adverse event in a newborn characterized by an abnormally low heart rate for age.


name: Grade 3 Gastroesophageal Reflux Disease, CTCAE

description: Severe symptoms; operative intervention indicated


Lacrimal Drainage System Melanoma

description: An extremely rare melanoma that arises from the lacrimal drainage system.


Metallosis

description: Aseptic fibrosis or local necrosis secondary to metal corrosion and release of wear debris.


Rectal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the lumen of the rectum.


name: Grade 5 Gallbladder Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Meninges Intra-Operative Injury, CTCAE


AIDS-Related Malignant Neoplasm

description: Malignant neoplasms that develop in HIV infected patients.  The most common AIDS-related malignant neoplasms are Kaposi sarcoma, non-Hodgkin lymphoma, anal carcinoma, cervical carcinoma, and Hodgkin lymphoma.


Unresectable Acral Lentiginous Melanoma

description: Acral lentiginous melanoma that is not amenable to surgical resection.


Locally Advanced Vaginal Carcinoma

description: Vaginal carcinoma that has spread to nearby tissues or lymph nodes.


name: Metastatic Pancreatic Acinar Cell Carcinoma

description: Pancreatic acinar cell carcinoma that has spread from its original site of growth to another anatomic site.


Cervical Cancer by AJCC v8 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 8th edition.


name: Grade 3 Liver Intra-Operative Injury, CTCAE


Chemical injury

description: Damage to body tissue caused by exposure to a chemical substance.


Grade 4 Aspiration, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Lymph Node Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in a lymph node.


Bullous Dermatitis, CTCAE

description: A disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid.


Disseminated Juvenile Xanthogranuloma

description: Juvenile xanthogranuloma disseminated to extracutaneous sites including mucosal surfaces, lung, central nervous system, pituitary, lymph nodes, eye, liver, and bone marrow. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells forming nodules in the affected anatomic sites.


name: Stage II Anal Canal Cancer AJCC v6 and v7

description: Stage II includes: (T2, N0, M0); (T3,N0, M0).  T2: Tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Grade 5 Metabolic or Respiratory Alkalosis, CTCAE


Recurrent Myeloid Leukemia

description: The reemergence of myeloid leukemia after a period of remission.


Fungemia, CTCAE

description: A disorder characterized by the presence of fungus in the blood stream.


name: Grade 4 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 2 Restrictive Cardiomyopathy, CTCAE

description: Symptomatic without signs of heart failure


name: Grade 1 Cytomegalovirus Infection Reactivation, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Small cell glioblastoma

description: A morphologic variant of glioblastoma characterized by the presence of a highly proliferative and monotonous population of malignant small glial cells.


Acquired Hypogonadotropic Hypogonadism

description: Hypogonadotropic hypogonadism, the cause of which is not present from birth.


name: Grade 2 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


name: Grade 5 Cornea Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Pharyngeal Anastomotic Leak, CTCAE

description: Death


name: Metastatic Urethral Urothelial Carcinoma

description: A urethral urothelial carcinoma that has spread to another anatomical site.


Childhood Appendix Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the appendix during childhood. It is usually located in the tip of the appendix. The vast majority of cases are grade 1 neuroendocrine tumors.


name: Rash and Dermatitis Associated with Chemoradiation, CTCAE


name: Grade 3 Muscle Weakness Left-Sided, CTCAE

description: Limiting self care ADL


name: Grade 4 Cerebrospinal Fluid Leakage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Childhood Lymphoma by AJCC v8 Stage

description: Staging systems for Hodgkin and non-Hodgkin lymphomas of childhood. Different systems are used for Hodgkin lymphoma and non-Hodgkin lymphoma of childhood. Staging of childhood Hodgkin lymphoma is the same as for the adult counterpart and is based on the Lugano classification criteria. The Ann Arbor staging system has been found to be inappropriate for staging of the non-Hodgkin lymphomas of childhood. The St. Jude staging system has been widely accepted and remains the recommended staging system for non-Hodgkin lymphomas of childhood. (from AJCC 8th Ed.)


name: Prostate Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Uterus Infection with Unknown Absolute Neutrophil Count, CTCAE


Hypoglossal Nerve Palsy

description: Partial or complete paralysis of the hypoglossal nerve.


name: Metastatic malignant neoplasm to extrahepatic bile ducts

description: A malignant neoplasm that has spread to the extrahepatic bile ducts from another anatomic site.  Representative examples include metastatic melanoma and metastatic breast and gastric carcinomas.


name: Grade 5 Penis Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Cutaneous epithelioid angiomatoid nodule

description: A distinctive benign cutaneous vascular proliferation with prominent epithelioid morphology. It appears to be reactive. (WHO 2018)


Stage IIIC Cervical Cancer AJCC v9

description: Stage IIIC includes: IIIC1: TX, T0, T1-3, N1, M0; IIIC2: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes.  M0: No distant metastasis. (from AJCC 9th Ed.)


Cervical Microglandular Hyperplasia

description: A benign endocervical gland proliferation characterized by the presence of closely packed glands composed of columnar to cuboidal cells with subnuclear mucin vacuoles. It is associated with progestins or pregnancy.


name: immune effector cell-associated neurotoxicity syndrome, grade 3

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0, 1, or 2 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of greater than or equal to 9 (for children 12 and under), the ability of the affected individual to awaken only to tactile stimulus, clinical focal or generalized seizures that resolve rapidly, or non-convulsive seizures detected by electroencephalography (EEG) that resolve with intervention, and local cerebral edema evident on neuroimaging.


Grade 3 Peripheral Ischemia, CTCAE

description: Prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated


name: Extrahepatic Bile Duct Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The Ki-67 index is higher than 20%.


name: Ampulla of Vater Somatostatin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor that arises from the ampulla of Vater and the periampullary region.  It produces somatostatin.


Recurrent Adenoid Cystic Carcinoma

description: The reemergence of adenoid cystic carcinoma after a period of remission.


Catheter related infection

description: An infection that arises secondary to catheter use.


Locally Advanced Cervical Carcinoma

description: A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Plexiform Neurofibroma

description: Plexiform neurofibroma that is not amenable to surgical resection.


Prostate Cancer by AJCC v8 Stage

description: A term that refers to the staging of prostate cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas and squamous cell carcinomas of the prostate gland. It does not apply to sarcomas, urothelial cell carcinomas, and urothelial carcinoma of bladder involving prostate. (from AJCC 8th Ed.)


name: Grade 3 Spermatic Cord Obstruction, CTCAE

description: Severe symptoms; invasive intervention indicated


name: Grade 3 Rectal Varices Hemorrhage, CTCAE


Grade 2 Salivary Gland Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Abnormal Finding on Diagnostic Imaging

description: An observation made during diagnostic imaging that is outside the parameters considered normal.


Grade 2 Pharyngeal Stenosis, CTCAE

description: Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


Grade 5 Chylous Ascites, CTCAE

description: Death


Cough, CTCAE

description: A disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound.


name: Peritoneal Cavity Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Jejunal Ulcer, CTCAE

description: A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the jejunum.


Grade 5 Pancreatic Hemorrhage, CTCAE

description: Death


Grade 2 Neonatal Hypertension, AE

description: An adverse event in a newborn characterized by persistent or recurrent hypertension, with systolic or diastolic blood pressure between the 95th percentile and the 99th percentile.


Locally Recurrent Carcinoma

description: The reemergence of carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Grade 3 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Advanced Transitional Cell Carcinoma

description: Transitional cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Refractory Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that is resistant to treatment.


Intraoperative Urinary Injury, CTCAE

description: A finding of damage to the urinary system during a surgical procedure.


Grade 4 Testicular Disorder, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Akathisia, CTCAE

description: A disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.


name: Grade 1 Cerebral Artery Intra-Operative Injury, CTCAE


name: Immune Checkpoint Inhibitor-Induced Dermatitis

description: Dermatitis associated with the therapeutic use of an immune checkpoint inhibitor.


Grade 2 Hypertriglyceridemia, CTCAE

description: >300 mg/dL-500 mg/dL; >3.42 mmol/L-5.7 mmol/L


name: Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Benign Supratentorial Neoplasms

description: A neoplasm that arises from above the cerebellar tentorium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Hypohidrosis, CTCAE

description: A disorder characterized by reduced sweating.


name: Desmoplastic Myxoid Tumor of the Pineal Region, SMARCB1-Mutant

description: A SMARCB1-deficient tumor of the brain arising in the pineal region. It is characterized by the presence of spindled and epithelioid cells with low-grade morphology that are embedded in a desmoplastic stroma alternating with various extents of loose myxoid matrix.


Death by electrocution

description: The passage of electrical current through the body.


name: Grade 5 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Bronchopleural Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Platinum-Resistant Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses between one and six months of completing platinum therapy.


name: Lymphomatoid Papulosis with DUSP22-IRF4 Gene Rearrangement

description: A variant of lymphomatoid papulosis associated with chromosomal rearrangements involving the DUSP22-IRF4 locus at 6p25.3.


name: Stage IIB Cervical Cancer AJCC v6 and v7

description: Stage IIB includes: T2b, N0, M0.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Grade 2 Electrocardiogram T Wave Abnormal, CTCAE

description: Nonspecific ST segment change


name: Grade 5 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


Weight Loss, CTCAE

description: A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve.


Mass lesion of brain

description: A benign or malignant solid pathologic process involving the brain and/or the meninges.


name: Grade 1 Small Intestinal Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Grade 2 Parathyroid Intra-Operative Injury, CTCAE


Grade 3 Cranial Nerve Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Disorder of AMH

description: Abnormally high or low anti-Müllerian hormone levels.


Childhood Gastroblastoma

description: A gastroblastoma that occurs during childhood.


name: Grade 1 Spermatic Cord Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 4 Intraoperative Hepatobiliary Injury, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 5 Gastric Fistula, CTCAE

description: Death


name: Squamous cell carcinoma with horn formation

description: A keratinizing squamous cell carcinoma characterized by the presence of horn pearls. Representative examples include squamous cell carcinomas of the face presenting as a cutaneous horn.


name: Grade 2 Retroperitoneal Hemorrhage, CTCAE

description: Self-limited; intervention indicated


Hamartoma of brain

description: A hamartoma that occurs in the brain.


name: Congenital Reproductive System Abnormality

description: A disorder that affects the female or male reproductive system and is present at birth. Representative examples include ovarian agenesis, vaginal agenesis, and penile agenesis.


Grade 3 Eye Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 4 Small Bowel Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Secondary Central Nervous System Hodgkin Lymphoma

description: A Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


name: Grade 3 Ileum Intra-Operative Injury, CTCAE


Grade 5 Pharyngeal Fistula, CTCAE

description: Death


name: Gastrointestinal Stricture and Stenosis Including Anastomotic Stricture and Stenosis, CTCAE


name: Grade 5 Vein Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Serum Glutamic Oxaloacetic Transaminase, CTCAE


name: Abdomen Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


name: Refractory Primary Central Nervous System Neoplasm

description: A primary central nervous system neoplasm that is resistant to treatment.


name: Prostate Ductal Adenocarcinoma, Solid Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of cribriform and/or papillary patterns and areas of solid nests of malignant cells.


name: Neck Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


name: Grade 4 Vaginitis Not Due to Infection, CTCAE


name: Grade 5 Soft Tissue Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Bronchopleural Fistula, CTCAE

description: Asymptomatic


name: Grade 5 Serum Hypertriglyceridemia, CTCAE


Parapharyngeal abscess

description: An abscess that develops in the soft tissues of the lateral pharyngeal space.


Locally Advanced Ocular Melanoma

description: Ocular melanoma that has spread from its original site of growth to nearby tissues.


name: Chest Pain in Left Fifth Intercostal Space

description: The location of the chest pain is within the fifth intercostal space on the left side.


name: Grade 5 Psychiatric Disorders - Other, Specify, CTCAE

description: Death


name: Grade 2 Urethra Stricture or Stenosis, CTCAE


name: Refractory Malignant Leptomeningeal Neoplasm

description: Malignant leptomeningeal neoplasm that is resistant to treatment.


Bone Cancer by AJCC v8 Stage

description: A term that refers to the staging of appendicular skeleton, trunk, skull, and facial bones cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to osteosarcoma, chondrosarcoma, Ewing sarcoma, spindle cell sarcoma, hemangioendothelioma, angiosarcoma, fibrosarcoma/myofibroid sarcoma, chordoma, adamantinoma, and other cancers arising in the bone. It does not apply to primary malignant lymphoma of the bone and multiple myeloma. There are no AJCC prognostic stage groupings for spine and pelvis. (from AJCC 8th Ed.)


Intraoperative Musculoskeletal Injury

description: Damage to any part of the musculoskeletal system during a surgical procedure.


name: Lugano Classification Stage IV Childhood Hodgkin Lymphoma AJCC v8

description: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


name: Grade 1 Ureteric Anastomotic Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


name: Low Grade Fallopian Tube Serous Adenocarcinoma

description: A slow-growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


name: Adverse Event Associated with the Heart in General


Fatigue, CTCAE 3.0

description: An unfavorable feeling of fatigue temporally associated with the use of a medical treatment or procedure.


Pharmacokinetic Effect Consequences

description: The outcome that results from chemical interactions between a drug and another drug or food.


Gait Disturbance, CTCAE

description: A disorder characterized by walking difficulties.


Grade 2 Bone Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 3 Jejunal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


Colonic Perforation, CTCAE

description: A disorder characterized by a rupture in the colonic wall.


name: Grade 2 Fallopian Tube Hemorrhage, CTCAE


Bronchial Obstruction, CTCAE

description: A disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates.


Grade 4 Ileal Stenosis, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 4 Stomach Stricture or Stenosis, CTCAE


name: Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma

description: The reemergence of low grade fallopian tube serous adenocarcinoma after a period of remission.


Decreased Drug AUC

description: Decreased area under the plot of plasma concentration of a drug against time after drug administration.


Minimal Deviation Melanoma

description: A melanocytic neoplasm displaying morphologic features that are intermediate between those of benign nevus and melanoma.  It is characterized by a nodular architectural growth resembling a melanoma, and a loss of nevus cell maturation.  The melanocytic cells forming the nodular growth are uniform, and they may display a high mitotic rate, but they do not show cytologic atypia.


name: Grade 4 Large Intestinal Anastomotic Leak, CTCAE


Adult Benign Cerebral Neoplasm

description: A benign neoplasm of the cerebrum occurring in adults.


name: Grade 2 Thrombosis or Thrombus or Embolism, CTCAE


Hemoglobinuria, CTCAE 5.0

description: A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.


Stage IIA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and measuring more than 4 cm in diameter. (FIGO 2009)


name: Prostate Acinar Pleomorphic Giant Cell Adenocarcinoma

description: An extremely rare prostate acinar adenocarcinoma characterized by the presence of giant, bizarre anaplastic cells with pleomorphic nuclei and lack of a spindle cell component.


name: Grade 1 Genitourinary Stoma Obstruction, CTCAE


Pancreatic Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site.


Penile Infection, CTCAE

description: A disorder characterized by an infectious process involving the penis.


name: FIGO Stage IVA Gestational Trophoblastic Tumor


Cusp tear

description: A split located on a leaflet of a heart valve that prevents its complete closing, which can result in valvular dysfunction.


Disturbance in mood

description: A change in disposition or state of mind.


name: Papillary squamous cell carcinoma, non-invasive

description: A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent tissues.


Grade 2 Pharyngeal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


Burning Pain

description: A sensation of intensely hot or searing discomfort.


Grade 1 Phantom Pain, CTCAE

description: Mild pain


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of low grade dysplasia.


Viral endocarditis

description: Endocarditis caused by a viral infection.


name: Grade 2 Extrapyramidal and Involuntary Movement and Restlessness, CTCAE


Grade 4 Hypoalbuminemia, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 1 Pharyngeal Fistula, CTCAE

description: Asymptomatic


name: Refractory Neoplastic Post-Transplant Lymphoproliferative Disorder

description: Neoplastic post-transplant lymphoproliferative disorder that is resistant to treatment.


name: Grade 5 Other Musculoskeletal and Soft Tissue, CTCAE


name: Grade 3 Vas Deferens Stricture or Stenosis, CTCAE


name: Grade 2 Duodenum Intra-Operative Injury, CTCAE


Grade 1 Prolapse of Urostomy, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Infantile Apnea, AE

description: An adverse event in a newborn characterized by apnea requiring stimulation and sustained fraction of inspired oxygen (FiO2) increase; requiring non-invasive ventilation; reoccurrences requiring start of or relevant increase in dose of respiratory stimulants or other major care changes.


AHL Amyloidosis

description: An extremely rare type of amyloidosis characterized by the monoclonal deposition of immunoglobulin heavy chain and light chain fragments in organs and tissues.


Bone Rosai-Dorfman-Destombes Disease

description: Rosai-Dorfman-Destombes disease affecting the bone.


name: Subarachnoid Hemorrhage Related to Birth

description: Bleeding within the subarachnoid space occurring during labor and/or delivery.


name: Unresectable Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that is not amenable to surgical resection.


Cushingoid, CTCAE

description: A disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids.


name: Neoplasm, malignant, uncertain whether primary or metastatic

description: A malignant neoplasm in which the examined tissue can not be determined with certainty if it represents the primary site of tumor growth or tumor spread from another anatomic site.


name: Grade 5 Spermatic Cord Hemorrhage, CTCAE

description: Death


Non-Neoplastic Brain Disorder

description: A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis.


name: Grade 2 Appendix Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Small Intestinal Anastomotic Leak, CTCAE

description: A finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel.


Grade 1 Dysgeusia, CTCAE

description: Altered taste but no change in diet


Presyncope, CTCAE

description: A disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope.


Stage II Bone Sarcoma AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Grade 3 Ureter Stricture or Stenosis, CTCAE


Grade 2 Colonic Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Grade 2 Ovulation Pain, CTCAE

description: Present


name: Unresectable Urethral Urothelial Carcinoma

description: Urethral urothelial carcinoma that is not amenable to surgical resection.


name: Stage I Appendix Neuroendocrine Tumor AJCC v7

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Grade 3 Supraventricular Tachycardia, CTCAE

description: Symptomatic, urgent intervention indicated


name: Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder

description: An early lesion of post-transplant lymphoproliferative disorder with the morphologic appearance of florid follicular hyperplasia.


name: Grade 5 Eye Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Malignant Hair Follicle Neoplasm

description: A neoplasm that arises from the hair follicle and metastasizes to other anatomic sites.


name: Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8

description: Stage IIIB includes: T1-4, N1b-3, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Acute promyelocytic leukemia - hypogranular variant

description: Acute promyelocytic leukemia in which the promyelocytes in the peripheral blood have paucity or absence of cytoplasmic granules and characteristic bilobed nuclei.


name: Locally Advanced Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Infarction of brain due to migraine

description: Migraine associated with an ischemic brain lesion.


name: Prostate Acinar Oncocytic Adenocarcinoma

description: An exceptionally rare acinar prostate adenocarcinoma characterized by the presence of malignant large cells with granular eosinophilic cytoplasm.


Lymphocyte Count Increased, CTCAE

description: A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow.


Grade 2 Lip Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Grade 2 Reversible Posterior Leukoencephalopathy Syndrome, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 2 Esophageal Perforation, CTCAE

description: Invasive intervention not indicated


name: Grade 2 Appendix Intra-Operative Injury, CTCAE


Spermatic Cord Obstruction, CTCAE 5.0

description: A disorder characterized by blockage of the normal flow of the contents of the spermatic cord.


Grade 3 Oral Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Meningeal Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Infiltration of the meninges by chronic myeloid leukemia, BCR-ABL1 positive.


name: Stage IV Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Congenital listeriosis

description: A bacterial infection by Listeria monocytogenes that is present at birth.


Mullerian Papilloma

description: A benign papillary neoplasm that arises from the cervix or vagina. It mostly occurs in prepubertal girls and rarely in adolescents or young adults. It is characterized by the presence of a fibrovascular core covered by cuboidal or columnar epithelial cells. Squamous metaplasia may be present. Cytologic atypia is absent.


name: Intraoperative Reproductive Tract Injury, CTCAE

description: A finding of damage to the reproductive organs during a surgical procedure.


Grade 1 Bronchial Fistula, CTCAE

description: Asymptomatic


name: Grade 5 Gastrointestinal Stoma Hemorrhage, CTCAE


Contact dermatitis caused by alkali

description: Contact dermatitis caused by exposure to alkalis.


Radon Exposure

description: Inhalation of radon gas which is found in rocks, soil and groundwater as a result of radioactive decay of uranium, thorium, or radium in the environment.


Adult Diffuse Large Cell Lymphoma

description: A B-or T-cell non-Hodgkin lymphoma composed of a diffuse large cell lymphocytic infiltrate occurring in adults.


Aplastic anemia due to radiation

description: Aplastic anemia caused by excessive absorption of radiation by the bone marrow.


name: Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential

description: A premalignant neurofibromatous neoplasm characterized by the presence of at least two of the following features: cytologic atypia, hypercellularity, less than 3 mitotic figures per 10 HPFs, and loss of neurofibroma architecture. It is associated with an increased risk of progression to malignant peripheral nerve sheath tumor.


name: Leukemia Secondary To Oncology Chemotherapy, CTCAE

description: A disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents.


Leg Ulcer

description: A circumscribed, inflammatory, and often suppurating lesion that causes necrosis of tissue on the skin of the limb comprising the hip, thigh, leg and foot.


Grade 4 Colonic Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Leukemia, Radiation-Induced

description: Leukemia that is caused by radiation.


Congenital anomaly of lens

description: Any anatomic abnormality or physiologic dysfunction of the lens of the eye that is present at the time of birth.


Average Body Weight Gain

description: The mean value of the amount of weight gained over a period of time.


Grade 4 Bronchial Stricture, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


Grade 1 Vagus Nerve Disorder, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IIIB Esophageal Cancer AJCC v7

description: Stage IIIB includes: For squamous cell carcinoma: T3, N2, M0, Any G, Tumor location: Any. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Grade 3 Activated Partial Thromboplastin Time Prolonged, CTCAE

description: >2.5 x ULN; bleeding


Brief depressive adjustment reaction

description: Temporary maladaptive depressive signs and symptoms associated with a life event.


name: Grade 4 Other Pulmonary and Upper Respiratory, CTCAE


name: Grade 1 Genitourinary Stoma Hemorrhage, CTCAE


Grade 3 Hemoglobin Increased, CTCAE

description: Increase in >4 g/dL


name: Grade 2 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Epithelioid glioblastoma

description: An IDH-wildtype glioblastoma characterized by the presence of large epithelioid cells with abundant eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli.


name: Grade 5 Joint Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 3 Trachea Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Lower Extremity Artery Intra-Operative Injury, CTCAE


name: Grade 2 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Pleural Hemorrhage, CTCAE

description: Death


Grade 3 Urinary Tract Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Grade 2 Outer Ear NOS Intra-Operative Injury, CTCAE


name: Eye Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils NOS, CTCAE


Arsenical keratosis

description: A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic.


Radiating Chest Pain to Other Location

description: An indication that the chest pain radiates to a location other than those listed.


Grade 1 Eczema, CTCAE

description: Asymptomatic or mild symptoms; additional medical intervention over baseline not indicated


name: Grade 5 Small Intestinal Anastomotic Leak, CTCAE

description: Death


Grade 1 Hematosalpinx, CTCAE

description: Minimal bleeding identified on imaging study or laparoscopy; intervention not indicated


Grade 5 Ileal Obstruction, CTCAE

description: Death


Unresectable Neuroendocrine Carcinoma

description: Neuroendocrine carcinoma that is not amenable to surgical resection.


Uterine Ligament Ependymoma

description: A rare neoplasm that arises from the broad or other uterine ligaments and shows ependymal differentiation.


Grade 4 Urine Output Decreased, CTCAE

description: Adult: Anuria (<240 ml in 24 hr); Pediatric: No urine output over 12 hours


name: Grade 4 Spermatic Cord Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Grade 4 Bone Intra-Operative Injury, CTCAE


name: Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor

description: A usually indolent neuroendocrine neoplasm that almost exclusively arises in the second part of the duodenum. Rare sites of involvement include jejunum, pylorus, appendix, thymus, and lung. It is a triphasic tumor consisting of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.


name: Stage 0 Esophageal Adenocarcinoma AJCC v7

description: Stage 0 includes: Tis (HGD), N0, M0, G1,GX.  Tis: High-grade dysplasia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Grade 2 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Esophageal Anastomotic Leak, CTCAE


Squamous Hyperplasia

description: A hyperplasia of the squamous epithelial cells.


Grade 3 Viremia, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated


Dry Desquamation

description: A skin reaction characterized by scaling and pruritus.


name: Malignant Neoplasm of Lung - Multiple Primary Sites

description: Lung cancer comprising malignant neoplasms from two or more sites, as determined by clinicoopathological assessment.


Epigastric hernia

description: Protrusion of abdominal cavity contents or pre-peritoneal fat through the abdominal wall between the umbilicus and the xiphoid process.


name: Grade 2 Cytomegalovirus Infection Reactivation, CTCAE

description: Moderate symptoms; medical intervention indicated


Lacrimal Gland Warthin Tumor

description: A rare benign tumor that arises from the lacrimal gland. It is characterized by an oncocytic epithelial component and dense lymphoid stroma.


Benign Dermal Neoplasm

description: A neoplasm that arises from the dermis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 2 Gallbladder Obstruction, CTCAE

description: Symptomatic; altered GI function; IV fluids indicated <24 hrs


Localized Prostate Adenocarcinoma

description: An adenocarcinoma that arises from the prostate and has not spread to other anatomic sites.


Grade 2 Ankle Fracture, CTCAE

description: Limiting instrumental ADL; outpatient operative intervention indicated


Congenital musculoskeletal anomalies

description: An abnormality of the musculoskeletal system that is present at birth or detected in the neonatal period.


name: Grade 5 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 2 Libido Decreased, CTCAE

description: Decrease in sexual interest adversely affecting relationship


name: Grade 3 Vascular Disorders - Other, Specify, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 2 Tumor Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Grade 5 Small Intestinal Perforation, CTCAE

description: Death


Cutaneous Melanoma by AJCC v7 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v7 classification system.


name: Grade 4 Vulva Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Brachial Plexopathy, CTCAE

description: Moderate symptoms; limiting instrumental ADL


name: Grade 3 Peripheral Arterial Ischemia, CTCAE


Grade 3 Pleural Effusion, CTCAE

description: Symptomatic with respiratory distress and hypoxia; operative intervention including chest tube or pleurodesis indicated


Advanced Favorable Hodgkin Lymphoma

description: An advanced Hodgkin lymphoma with favorable prognosis.


Non-Neoplastic Pleural Disorder

description: A non-neoplastic disorder that affects the pleura.  Representative examples include pleural infection and pneumothorax.


Hypertrichosis, CTCAE

description: A disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race.


Childhood Compound Nevus

description: A compound nevus that occurs during childhood.


name: Grade 1 Upper Airway NOS Intra-Operative Injury, CTCAE


Trigeminal nerve palsy

description: Partial or complete paralysis of the trigeminal nerve.


Abnormal Cardiac Study

description: A history of having had an abnormal cardiac study.


Grade 5 Duodenal Perforation, CTCAE

description: Death


name: Grade 2 Pharynx Obstruction and Stenosis, CTCAE


Overt Stroke

description: A cerebral infarction that is evident by new neurological symptoms lasting greater than 24 hours or having an area of diffusion restriction or a T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensity on an MRI of the brain that was consistent with the neurological findings.


Vital Capacity Abnormal, CTCAE

description: A finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value.


name: Pelvis Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


name: Grade 3 Pelvis Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Locally Advanced Pancreatic Carcinoma

description: A pancreatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Acute Erythroid Leukemia

description: An acute erythroid leukemia occurring in children.


Malaise, CTCAE

description: A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.


name: Grade 2 Hypoglossal Nerve Disorder, CTCAE


name: Verrucous carcinoma of the oral cavity stage I


Tracheal Stenosis, CTCAE

description: A disorder characterized by a narrowing of the trachea.


Grade 1 Lip Pain, CTCAE

description: Mild pain


name: Refractory Endometrial Serous Adenocarcinoma

description: Endometrial serous adenocarcinoma that is resistant to treatment.


Grade 2 Dyspepsia, CTCAE

description: Moderate symptoms; medical intervention indicated


name: Lacrimal Drainage System Adenoid Cystic Carcinoma

description: A carcinoma that arises from the lacrimal sac. It is characterized by the presence of malignant epithelial cells that form cribriform, tubular, and solid patterns.


Skin Hyperpigmentation, CTCAE

description: A disorder characterized by darkening of the skin due to excessive melanin deposition.


Duodenal Hemorrhage, CTCAE

description: A disorder characterized by bleeding from the duodenum.


name: Recurrent Endometrial Dedifferentiated Carcinoma

description: The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


name: Pregnancy, Puerperium and Perinatal Conditions, CTCAE


Adult Benign Brain Neoplasm

description: A benign neoplasm of the brain occurring in adults.


name: Metastatic Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: Prostate adenocarcinoma with neuroendocrine differentiation that has spread from its original site of growth to another anatomic site.


Grade 3 Myocarditis, CTCAE

description: Severe with symptoms at rest or with minimal activity or exertion; intervention indicated; new onset of symptoms


name: Grade 2 Transient Ischemic Attacks, CTCAE

description: Moderate neurologic deficit with or without imaging confirmation


Grade 2 Skin Hyperpigmentation, CTCAE

description: Hyperpigmentation covering >10% BSA; associated psychosocial impact


name: Clear Cell Tumor with Melanocytic Differentiation and ACTIN-MITF Translocation

description: A MITF pathway-activated melanocytic tumor characterized by a cytogenetic translocation between ACTIN and MITF genes that results in ACTIN-MITF gene fusion. It presents as a single non-pigmented cutaneous nodule in the distal extremities or trunk. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis without an intraepidermal component. Extension in the subcutaneous tissue is frequently seen. Atypical nuclear features may be present. It has an indolent clinical course.


name: Grade 1 Artery NOS Intra-Operative Injury, CTCAE


name: Cranial Nerve I Intra-Operative Injury, CTCAE


name: Metastatic Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


Grade 4 Neck Edema, CTCAE

description: Vascular or respiratory impairment requiring urgent intervention


name: Grade 2 Cervix Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 1 Premature Delivery, CTCAE

description: Delivery of a liveborn infant at >34 to 37 weeks gestation


Grade 3 Rectal Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated


Peripheral Motor Neuropathy, CTCAE

description: A disorder characterized by damage or dysfunction of the peripheral motor nerves.


Grade 5 Duodenal Fistula, CTCAE

description: Death


name: Adnexal Adenocarcinoma, Not Otherwise Specified

description: An adnexal carcinoma with ductal/glandular differentiation lacking specific histological features that would allow further classification. (WHO 2018)


description: A hematologic malignancy that arises in a patient with a history of organ transplantation.


name: Grade 3 Cranial Nerve Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Ileal Perforation, CTCAE

description: Invasive intervention not indicated


name: Stomach Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 CD4 Lymphocytes Decreased, CTCAE

description: <200-50/mm3; <0.2 x 0.05-10e9/L


name: Grade 4 Neuroendocrine ACTH Deficiency, CTCAE


Childhood Benign Skin Neoplasm

description: A childhood neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Grade 5 Vaginal Fistula, CTCAE

description: Death


Recurrent Endometrial Cancer

description: The reemergence of endometrial carcinoma after a period of remission.


name: Complex endometrial hyperplasia without atypia

description: A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures. Epithelial atypia is absent.


Chest Wall Disorder

description: A non-neoplastic or neoplastic disorder that affects the structures of the chest wall.  Representative examples include infection, chest wall lipoma, and chest wall lymphoma.


name: Grade 3 CNS Cerebrovascular Ischemia, CTCAE


Grade 3 Encephalopathy, CTCAE

description: Severe symptoms; limiting self care ADL


Metastatic adenoid cystic carcinoma

description: An adenoid cystic carcinoma that has spread from the original site of growth to other anatomic sites.


name: Grade 1 Reduction in Growth Velocity, CTCAE


Epstein-Barr virus infection recurrent

description: An Epstein-Barr virus infection that has recurred after a period of remission.


Cervical myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the cervical region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


name: Metastatic Malignant Neoplasm in the Lacrimal System

description: A malignant neoplasm that has spread from its original site of growth to the lacrimal gland or lacrimal drainage system.


name: Somnolence and Depressed Level of Consciousness, CTCAE


Nutritional Hypophosphatemic Rickets

description: Hypophosphatemic rickets due to insufficient dietary phosphate intake or absorption.


name: Grade 2 Neuroendocrine Growth Hormone Secretion Abnormality, CTCAE


Grade 1 Neonatal Constipation, AE

description: An adverse event in a newborn characterized by reduced number of stools or hard stools; no apparent discomfort.


name: Grade 5 Prolonged Intubation After Pulmonary Resection, CTCAE


Adult Intracranial Germ Cell Tumor

description: A germ cell tumor that arises within the cranium and occurs during adulthood.


name: Stage I Childhood Retinoblastoma by Toronto Guidelines v2

description: Enucleation with negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Phlebitis of portal vein

description: Inflammation of the portal vein.


name: Grade 3 Bone Growth Limb Length Discrepancy, CTCAE


Basal-Like Prostate Carcinoma

description: Prostate carcinoma in which the CD49f signature is increased, the luminal markers and androgen receptor expression and signaling (androgen activity pathway) are not increased, and the proliferation score is higher than the luminal A prostate carcinoma.


Anal Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin.


Stage II Gallbladder Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Grade 2 Laryngopharyngeal Dysesthesia, CTCAE

description: Moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and/or anxiolytic indicated; limiting instrumental ADL


Grade 3 Urinary Fistula, CTCAE

description: Invasive intervention indicated


Gestational diabetes mellitus class A2

description: Carbohydrate intolerance first diagnosed during pregnancy. Diagnosis from abnormal oral glucose tolerance test (OGTT) and abnormal fasting or post-prandial glucose levels. Euglycemia achieved with medication.


name: Stage II Intermediate Grade Adult Non-Hodgkin's Lymphoma


name: Stage IIIA Uterine Corpus Cancer AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus carcinoma or carcinosarcoma with tumor involving the serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Grade 2 Catheter Related Infection, CTCAE

description: Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Tumor Lysis Syndrome, CTCAE 5.0

description: A disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells.


Grade 5 Feeding Intolerance, AE

description: A feeding intolerance adverse event in a newborn which results in death.


name: Grade 1 Upper Extremity Artery Intra-Operative Injury, CTCAE


Grade 4 Capillary Leak Syndrome, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Unresectable Digestive System Carcinoma

description: Digestive system carcinoma that is not amenable to surgical resection.


Recurrent basal cell carcinoma

description: The reemergence of basal cell carcinoma after a period of remission.


Unacceptable Toxicity

description: Therapy-related toxicity leading to multiple treatment dose reductions or delays, early treatment stoppage, unplanned hospital admission, or death.


Grade 1 Pericarditis, CTCAE

description: Asymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis


Refractory Childhood Malignant Neoplasm

description: A childhood malignant neoplasm that does not respond to treatment.


Grade 1 Esophagitis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Spinal Cord Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Cutaneous Melanoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Grade 4 Hepatic Failure, CTCAE

description: Life-threatening consequences; moderate to severe encephalopathy; coma


Current EBV Infection

description: Epstein-Barr virus infection is evident at the time of testing.


Infection pyogenic

description: An infection caused by pus-producing organisms.


name: Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood ependymoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Vasculitic ulcer

description: A circumscribed inflammatory lesion associated with underlying ischemic disease.


Pulmonary Embolism Related to COVID-19

description: Pulmonary embolism in a patient with probable or confirmed acute COVID-19.


name: Grade 1 Superior Vena Cava Syndrome, CTCAE

description: Asymptomatic; incidental finding of SVC thrombosis


Voice Alteration, CTCAE

description: A disorder characterized by a change in the sound and/or speed of the voice.


name: Grade 4 Upper Airway Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Vertigo, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Grade 4 Corneal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 5 Bladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Third degree uterine prolapse

description: The uterus has descended below the level of the hymen and protrudes through the opening of the vagina.


Pneumothorax, CTCAE

description: A disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung.


Grade 4 Biliary Anastomotic Leak, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Grade 1 Pulmonary Fistula, CTCAE

description: Asymptomatic


name: Grade 1 Fallopian Tube Hemorrhage, CTCAE


name: Stage III Pancreatic Cancer AJCC v6 and v7

description: Stage III includes: T4, Any N, M0. T4: Tumor involves the celiac axis or the superior mesenteric artery.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Grade 2 Esophagitis, CTCAE

description: Symptomatic; altered eating/swallowing; oral supplements indicated


name: Recurrent Acute Myeloid Leukemia with Multilineage Dysplasia

description: The reemergence of acute myeloid leukemia with multilineage dysplasia after a period of remission.


Grade 3 Breast Atrophy, CTCAE

description: Asymmetry >1/3 of breast volume; severe atrophy


Grade 1 Ataxia, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Stage IVB Appendix Carcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1b, G2, G3, or GX. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G2: Moderately differentiated. G3: Poorly differentiated. GX: Grade cannot be assessed.  (AJCC 8th ed.)


name: Metastatic Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread to another anatomic site.


name: Non-Neoplastic Trigeminal Nerve Disorder

description: A non-neoplastic disorder affecting the trigeminal nerve.


name: Serum Soluble Fas Ligand Level Increased

description: An indication that the concentration of soluble Fas ligand in a sample has increased when compared to a normal baseline or a previous sample measurement.


Neonatal Culture Negative Sepsis, AE

description: An adverse event in a newborn characterized by a systemic inflammatory response without identifiable cause.


name: Stage II Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor extends beyond kidney but completely resected. Tumor penetrates renal capsule. Tumor in lymphatics or veins of renal sinus. Tumor in renal vein with margin not involved. No nodal or hematogenous metastases. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Unresectable Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is not amenable to surgical resection.


Edema Trunk

description: Swelling due to an excessive accumulation of fluid in trunk area.


Pelvic Floor Disorders

description: A disorder affecting the muscles of the pelvic floor.


name: FIGO Stage IV Gestational Trophoblastic Tumor

description: Gestational trophoblastic tumor in all other metastatic sites.


name: Grade 2 Middle Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Oropharyngeal Pain, CTCAE

description: Severe pain; severely altered eating/swallowing; narcotics initiated; requires parenteral nutrition


Focal KATP-Associated Hyperinsulinism

description: KATP-associated hyperinsulinism in which there is an area of adenomatous beta-cell hyperplasia. This condition results from paternal recessive mutation(s) in either the ABCC8 or the KCNJ11 gene and paternal uniparental isodisomy of chromosome region 11p15 with loss of tumor suppressor genes expressed from the maternally inherited chromosome.


name: Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Vision Decreased, CTCAE

description: A disorder characterized by a decrease in visual acuity.


name: Neck Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Grade 4 Jejunal Hemorrhage, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Ovarian Infection, CTCAE

description: A disorder characterized by an infectious process involving the ovary.


Locally Advanced High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Benign Childhood Central Nervous System Neoplasm

description: A childhood neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Spinal Cord Compression, CTCAE

description: A disorder characterized by pressure on the spinal cord.


name: Grade 1 Vas Deferens Stricture or Stenosis, CTCAE


name: FIGO Stage IIIB Gestational Trophoblastic Tumor


Stage IVB Vulvar Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, M1.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th and 7th eds.)


name: Recurrent Adult Diffuse Mixed Cell Lymphoma

description: The reemergence of adult diffuse mixed cell lymphoma after a period of remission.


name: Grade 2 Other Dermatology or Skin, CTCAE


name: Grade 2 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Refractory Carcinoma

description: A carcinoma that does not respond to treatment.


Multifocal Glioblastomas

description: The occurrence of multiple and independent glioblastomas that are unrelated to inherited neoplastic syndromes.


name: Grade 3 Pancreas Exocrine Enzyme Deficiency, CTCAE


name: Metastatic Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


Grade 3 Gastric Anastomotic Leak, CTCAE

description: Severe symptoms; invasive intervention indicated


Gastroenteritis enteroviral

description: Gastroenteritis resulting from an infection with enterovirus.


name: Grade 4 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Hypoglycemia, CTCAE

description: <55-40 mg/dL; <3.0-2.2 mmol/L


Intraoperative Cardiac Injury, CTCAE

description: A finding of damage to the heart during a surgical procedure.


name: Grade 3 Slipped Capital Femoral Epiphysis, CTCAE


name: Grade 4 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Accelerated Phase Primary Myelofibrosis

description: Rapid progression of primary myelofibrosis, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


Grade 4 Ileal Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


name: Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Resectable Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that is amenable to surgical resection.


name: Childhood Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during childhood.


Grade 1 Hypokalemia, CTCAE

description: <LLN-3.0 mmol/L


Grade 2 Pharyngitis, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Grade 4 Thoracodorsal Nerve Intra-Operative Injury, CTCAE


Grade 1 Bruising, CTCAE

description: Localized or in a dependent area


Grade 3 Renal Calculi, CTCAE

description: Hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective invasive intervention indicated


Grade 4 Fracture, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Vasculitis, CTCAE

description: A disorder characterized by inflammation involving the wall of a vessel.


name: Grade 2 Thorax Soft Tissue Necrosis, CTCAE


name: Prostate Carcinoma by Gene Expression Profile

description: A header term that includes the following prostate carcinoma subtypes determined by gene expression profiling: luminal A prostate carcinoma, luminal B prostate carcinoma, and basal-like prostate carcinoma.


Prostatic Basal Cell Hyperplasia

description: A type of prostatic hyperplasia.  It is characterized by the presence of nodules of dark basal cells around residual prostatic secretory cells.


name: Recurrent Acute Myeloid Leukemia Not Otherwise Specified

description: The reemergence of acute myeloid leukemia not otherwise specified after a period of remission.


name: Vein Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Vaginal Inflammation, CTCAE

description: Moderate discomfort or pain, edema, or redness; limiting instrumental ADL


Benign neoplasm of cranial nerves

description: A neoplasm that arises from a cranial nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Refractory Acute Leukemia of Ambiguous Lineage

description: Acute leukemia of ambiguous lineage that is resistant to treatment.


name: Grade 5 Otitis Middle Ear Non Infectious, CTCAE


name: Grade 2 Testis Intra-Operative Injury, CTCAE


name: Grade 1 Nodal or Junctional Rhythm, CTCAE


name: Grade 2 Trigeminal Nerve Disorder, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Childhood Giant Cell Glioblastoma

description: A giant cell glioblastoma that occurs during childhood.


Syphilitic endocarditis

description: Endocarditis secondary to syphilis.


name: Grade 4 Soft Tissue Infection NOS with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Stomach Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Esophageal Perforation, CTCAE

description: A disorder characterized by a rupture in the wall of the esophagus.


Non-Neoplastic Retinal Disorder

description: A non-neoplastic disorder that affects the retina.


name: Grade 1 Other Constitutional Symptoms, CTCAE


Grade 2 Urostomy Leak, CTCAE

description: Symptomatic; medical intervention indicated


Grade 3 Chest Pain - Cardiac, CTCAE

description: Pain at rest; limiting self care ADL; cardiac catheterization; new onset cardiac chest pain; unstable angina


description: The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission.


Grade 3 Pharyngolaryngeal Pain, CTCAE

description: Severe pain; limiting self care ADL


name: Childhood Acute Myeloid Leukemia Not Otherwise Specified

description: Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related.  This category includes entities classified according to the French-American-British classification scheme.


Cervical Blue Nevus

description: A nevus that arises from the cervix. It is characterized by the presence of benign, heavily pigmented dendritic melanocytes.


Grade 3 Bile Duct Stenosis, CTCAE

description: Severely altered GI function; invasive intervention indicated


name: Grade 4 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Dyspnea with No Physical Activity Limitation

description: Dyspnea that does not interfere with their physical activity.


Congenital Disruption

description: A morphologic defect of an organ, part of an organ, or a larger region of the body that results from the extrinsic breakdown of, or an interference with, an originally normal developmental process.


Transient Organic Mental Disorder

description: An organic mental disorder that is temporary in nature.


Elevated CA15-3

description: A laboratory test result indicating the presence of an increased level of the tumor-associated antigen (TAA) CA15-3 in a blood or serum sample.


Small Intestinal Obstruction, CTCAE

description: A disorder characterized by blockage of the normal flow of the intestinal contents of the small intestine.


Grade 5 Bronchopleural Fistula, CTCAE

description: Death


Grade 4 Atrial Flutter, CTCAE

description: Life-threatening consequences; embolus requiring urgent intervention


Atrial Septum Lipomatous Hypertrophy

description: A condition in which deposits of fat accumulate within the interatrial septum.


name: EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


name: Shared Neoantigen-Positive Malignant Solid Neoplasm

description: A malignant solid neoplasm that expresses unique tumor-specific neoantigens across a subset of patients.


name: Grade 1 Pharynx Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Radiation-Related Sarcoma

description: A sarcoma that arises in the bones or soft tissues following exposure to ionizing or non-ionizing radiation.


name: Recurrent Chronic Myelomonocytic Leukemia

description: The reemergence of chronic myelomonocytic leukemia after a period of remission.


Iron Overload, CTCAE

description: A disorder characterized by accumulation of iron in the tissues.


Appendix Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Grade 5 Rectal Necrosis, CTCAE

description: Death


Grade 1 Ileal Stenosis, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


Grade 3 Glucose Intolerance, CTCAE

description: Severe symptoms; insulin indicated


Grade 1 Prostatic Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Menorrhagia, CTCAE

description: A disorder characterized by abnormally heavy vaginal bleeding during menses.


Stage IA1 Cervical Cancer AJCC v9

description: Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Grade 2 Duodenal Stenosis, CTCAE

description: Symptomatic; altered GI function


Grade 4 Hypertriglyceridemia, CTCAE

description: >1000 mg/dL; >11.4 mmol/L; life-threatening consequences


Grade 2 Urinary Tract Infection, CTCAE

description: Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Grade 2 Confusion, CTCAE

description: Moderate disorientation; limiting instrumental ADL


Grade 2 Papilledema, CTCAE

description: Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)


name: Acute Myeloid Leukemia with t(3;12)(q26.2;p13.2); ETV6-MECOM

description: An acute myeloid leukemia associated with t(3;12)(q26.2;p13.2) resulting in the expression of ETV6-MECOM fusion gene.


Grade 3 Restlessness, CTCAE

description: Severe symptoms; limiting self care ADL


name: Advanced Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 2 Endocrine Disorders - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Connective and Soft Tissue Disorder

description: A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


name: Metastatic Proximal Gastric Adenocarcinoma

description: A proximal gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Basal Cell Carcinoma with Adnexal Differentiation

description: A basal cell carcinoma of the skin that is characterized by adnexal differentiation.


name: Central Nervous System Histiocytic and Dendritic Cell Neoplasm

description: A neoplasm that originates from histiocytes and accessory cells and affects the central nervous system.  It is usually associated with the presence of identical tumors outside the central nervous system.  Representative examples include Langerhans cell histiocytosis, histiocytic sarcoma, and follicular dendritic cell sarcoma.


Grade 5 Stroke, CTCAE

description: Death


Pharyngolaryngeal Pain

description: Painful sensation in the pharyngolaryngeal region.


name: Grade 3 Inferior Vena Cava Intra-Operative Injury, CTCAE


Breast Infection, CTCAE

description: A disorder characterized by an infectious process involving the breast.


name: Grade 5 Esophagus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


Grade 4 Uveitis, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


name: Grade 2 Anal or Perianal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Metastatic Bladder Nested Urothelial Carcinoma

description: Bladder nested urothelial carcinoma that has spread to another anatomic site.


name: Perianal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process involving the squamous epithelium of the perianal skin. Clinically, it usually presents as a white or red area in the perianal skin. Morphologically, it is characterized by full thickness dysplasia of the squamous epithelium and sometimes of the pilosebaceous epithelium. Human papillomavirus DNA sometimes may be identified in the dysplastic epithelium. It may recur after treatment, however only a small percentage of cases progress to squamous cell carcinoma.


Cholesterol High, CTCAE

description: A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen.


Infectious Mediastinitis

description: An acute or chronic infectious process affecting the mediastinum.


Placenta, Retained

description: After delivery of neonate, placental retention that requires clinical intervention such as manual extraction, curettage or uterotonic medications.


Road Injury

description: An injury that occurs on a road or motor way.


name: Grade 1 Neck NOS Intra-Operative Injury, CTCAE


Grade 3 Vaginal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


name: Grade 4 Peripheral Nerve Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Merkel Cell Polyoma Virus-Positive Merkel Cell Carcinoma

description: A Merkel cell carcinoma that is associated with Merkel cell polyoma virus infection.


name: Grade 2 Salivary Gland Intra-Operative Injury, CTCAE


Elevated Urine Alkaline Phosphatase

description: An elevated concentration of alkaline phosphatase in the urine.


Infratentorial Glioblastoma

description: A glioblastoma that occurs in the infratentorial region.


name: Malignant Lymphoma Follicular, Large Cleaved Cell Type


Scrotal Pain, CTCAE 5.0

description: A disorder characterized by a sensation of marked discomfort in the scrotal area.


name: Grade 5 Esophagus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

description: A trichoblastoma characterized by the presence of neoplastic epithelial cell forming nodules. There are palisaded basaloid cells present at the periphery and pale larger cells with vesicular nuclei, prominent nucleoli, and abundant cytoplasm present at the center of the nodules. The epithelial cells are admixed with numerous small lymphocytes and occasional large multinucleated cells that resemble Reed-Sternberg cells.


Urine Output Decreased, CTCAE

description: A finding based on test results that indicate urine production is less relative to previous output.


name: Congenital Abnormalities of Erythrocyte Differentiation or Function

description: Inherited disorders involving abnormalities of red blood cell function, structure, or production. Some diseases in this group may be associated with bone marrow failure, neutropenia, and/or thrombocytopenia.


name: Utricle-Associated Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the area of the utricle.


Acquired Cytomegaloviral Infection

description: An infection with the Cytomegalovirus that is not present from birth.


name: Grade 2 Small Intestine Infection, CTCAE

description: Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


Biliary System Disorder

description: A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Increased Concomitant Drug Level

description: An increase in the level of a concomitant drug.


Adrenal Gland Hyperplasia II

description: Decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD3B2 gene. The lack of activity of this enzyme produces a type of congenital adrenal hyperplasia.


name: Grade 2 Skin Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Cranial Nerve IV Intra-Operative Injury, CTCAE


Grade 1 Intestinal Stoma Leak, CTCAE

description: Asymptomatic diagnostic finding; intervention not indicated


Grade 3 Suicide Attempt, CTCAE

description: Suicide attempt or gesture without intent to die


name: Grade 3 Voice Changes and Dysarthria, CTCAE


name: Grade 3 Ureter Infection with Unknown Absolute Neutrophil Count, CTCAE


Refractory Gastric Adenocarcinoma

description: Gastric adenocarcinoma that is resistant to treatment.


name: Cranial Nerve IX Motor Intra-Operative Injury, CTCAE


name: Grade 5 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Vaginal Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4).  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 6th and 7th eds.)


Early Stage Cervical Carcinoma

description: A stage term that refers to cervical carcinoma stages IA, IB, and IIA.


name: Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that is not amenable to surgical resection.


name: Grade 4 Ungual Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Catheter-Related Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Skin Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Granuloma of conjunctiva

description: A granuloma located on the conjunctiva, usually involving the inner surface of the eyelid.


name: Grade 2 Forced Expiratory Volume Decreased, CTCAE

description: FEV1 60-69%


Terminal Hematuria

description: Gross hematuria that occurs at the end of, or immediately after voiding.


name: Grade 5 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 2 Ileal Obstruction, CTCAE

description: Symptomatic; altered GI function; limiting instrumental ADL; naso-gastric tube indicated


name: Unresectable Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is not amenable to surgical resection.


name: Prostatic Clear Cell Cribriform Hyperplasia

description: A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


Unexpected Adverse Drug Reaction

description: An adverse drug reaction, whose nature, severity, specificity, or outcome is not consistent with the term or description used in the applicable product information (e.g., IB for an unapproved investigational product or PI/summary of product characteristics for an approved product, and/or scientific literature). (ICH)


name: Grade 4 Anus Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 3 Bone Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Induction Death

description: Death of the patient due to the toxic side effects of induction therapy.


Grade 5 Spinal Fracture, CTCAE

description: Death


name: Grade 4 Pelvis Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Abdomen Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Crushing injury

description: Traumatic compression of the body or a part of the body.


name: Grade 5 Other Hemorrhage and Bleeding, CTCAE


Grade 5 Esophageal Ulcer, CTCAE

description: Death


Grade 5 Colonic Fistula, CTCAE

description: Death


Metastatic Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to another anatomic site.


Grade 2 Fever, CTCAE

description: >39.0-40.0 degrees C (102.3-104.0 degrees F)


Stage IA Fallopian Tube Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Fallopian tube cancer with tumor limited to fallopian tube surface; no malignant cells in ascites or peritoneal washings N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Increase in B-type Natriuretic Peptide or N-terminal pro-B-type Natriuretic Peptide

description: A finding of an increased amount of either B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide


Increased Drug AUC

description: Increased area under the plot of plasma concentration of a drug against time after drug administration.


name: Grade 3 Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Digestive System Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant small cells.


Early Localized Lyme Disease

description: An early stage of Lyme disease that may present within 3-30 days after a tick bite with a red, concentrically-expanding rash (erythema migrans), fatigue, chills, fever, headache, muscle and joint aches, and swollen lymph nodes.


Receptor Status

description: Refers to the presence or absence of specific receptor molecules on the surface of a cells in a specimen.


Deficiency of vitamin D3

description: Abnormally low concentration of vitamin D3 (cholecalciferol) in the blood.


name: Grade 2 Radiation Excluding Chemoradiation, CTCAE


Stage IIIA Anal Cancer AJCC v8

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Grade 1 Gastrointestinal Disorders - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


Grade 1 Ileal Ulcer, CTCAE

description: Asymptomatic; clinical or diagnostic observations only; intervention not indicated


name: Grade 2 Cranial Nerve III Neuropathy, CTCAE


Grade 4 Pleural Hemorrhage, CTCAE

description: Life-threatening consequences; intubation or urgent intervention indicated


Neonatal Culture Positive Sepsis, AE

description: An adverse event in a newborn characterized by a systemic inflammatory response to an infection with an identifiable cause.


name: Locally Advanced Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Breast Neoplasm

description: A neoplasm that affects the breast and occurs during childhood.