name: TYPH_ECOLI Thymidine phosphorylase (sprot)

description: A thymidine phosphorylase that is encoded in the genome of Escherichia coli K-12.


DPP4_RAT Dipeptidyl peptidase 4 (sprot)

A dipeptidyl peptidase 4 that is encoded in the genome of rat.


name: Q9TZZ6_TRYBG ornithine decarboxylase (trembl)


name: OX1R_HUMAN Orexin/Hypocretin receptor type 1 (sprot)

description: An orexin/hypocretin receptor type 1 that is encoded in the genome of human.


name: F16P1_HUMAN Fructose-1,6-bisphosphatase 1 (sprot)

description: A fructose-1,6-bisphosphatase 1 that is encoded in the genome of human.


P2RY1_MELGA P2Y purinoceptor 1 (sprot)

A P2Y purinoceptor 1 that is encoded in the genome of turkey.


name: AT1A2_PIG Sodium/potassium-transporting ATPase subunit alpha-2 (sprot)


proscillaridin

mrdef: A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).


ouabain

mrdef: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.

description: A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.


name: S28A1_HUMAN Sodium/nucleoside cotransporter 1 (sprot)

description: A sodium/nucleoside cotransporter 1 that is encoded in the genome of human.


name: SC5A2_HUMAN Sodium/glucose cotransporter 2 (sprot)

description: A sodium/glucose cotransporter 2 that is encoded in the genome of human.


name: JAK3_HUMAN Tyrosine-protein kinase JAK3 (sprot)

description: A tyrosine-protein kinase JAK3 that is encoded in the genome of human.


esatenolol

The (S)-enantiomer of atenolol.


toliprolol

mrdef: was MH 1975-92 (see under PROPANOLAMINES 1981-90, was DOBEROL see under PROPANOLAMINES 1975-80); KOE 592 was see TOLIPROLOL 1975-92; use PROPANOLAMINES to search TOLIPROLOL 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris


practolol

mrdef: A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.

description: N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.


xamoterol

mrdef: A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.


tretoquinol

mrdef: An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.


prenalterol

mrdef: A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.


etilefrine

mrdef: A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.


dilevalol

A 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide that has 1R,2R-configuration.


clorprenaline

A racemate comprise of equimolar amounts of (R)- and (S)-clorprenaline. It is a beta2-adrenergic receptor agonist and a bronchodilator.


bopindolol

A methylindole that is 2-methyl-1H-indol-4-ol in which the hydrogen of the hydroxy group is replaced by a 2-(benzoyloxy)-3-(tert-butylamino)propyl group.


bevantolol

mrdef: a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension

description: A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension.


alprenolol

mrdef: One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

description: A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent.


levdobutamine

mrdef: Levdobutamine, an investigational drug, is a  beta-adrenoceptor agonist selective for the beta1-subtype. It is the cardiotonic agent.

description: The (S)-enantiomer of dobutamine.


name: CNR1_HUMAN Cannabinoid receptor 1 (sprot)

description: A cannabinoid receptor 1 that is encoded in the genome of human.


N-palmitoylethanolamine

mrdef: a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection; structure

smiles: CCCCCCCCCCCCCCCC(=O)NCCO

description: An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.


name: NR1I3_HUMAN Nuclear receptor subfamily 1 group I member 3 (sprot)

description: A nuclear receptor subfamily 1 group I member 3 that is encoded in the genome of human.


name: SCN3B_HUMAN Sodium channel regulatory subunit beta-3 (sprot)

description: A sodium channel subunit beta-3 that is encoded in the genome of human.


hydroquinidine

mrdef: urinary quinine metabolite; RN given refers to (9S)-isomer; structure in Merck Index, 9th ed, #4703


deracoxib

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.


name: PGH1_HUMAN Prostaglandin G/H synthase 1 (sprot)

description: A prostaglandin G/H synthase 1 that is encoded in the genome of human.


firocoxib

mrdef: A COX-2 inhibitor

description: An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs.


α-linolenic acid

mrdef: A fatty acid that is found in plants and involved in the formation of prostaglandins.

smiles: CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O

description: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.


eugenol

mrdef: A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS.

description: A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis.


linoleic acid

mrdef: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)

smiles: CCCCC\C=C/C\C=C/CCCCCCCC(O)=O

description: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.


tolfenamic acid

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.


pirprofen

mrdef: anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin; structure


oxametacin

A hydroxamic acid obtained by formal condensation of the carboxy group of indometacin with the amino group of hydroxylamine.


monobenzone

status: OFM

description: The monobenzyl ether of hydroquinone.  It is used as a topical drug for medical depigmentation.


mofezolac

mrdef: Cyclooxygenase 1 inhibitor; ; RN from Toxlit


isoxicam

A monocarboxylic acid amide that is piroxicam in which the pyrid-2-yl group is replaced by a 5-methyl-1,2-oxazol-3-yl group. A non-steroidal anti-inflammatory drug, it was withdrawn from the market in the 1980s following its association with cases of Stevens-Johnson syndrome.


fenbufen

mrdef: an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity


aminophenazone

mrdef: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.

description: A  pyrazolone  that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.


name: DPOL_HHV11 DNA polymerase catalytic subunit (sprot)

description: A protein that is a translation product of the UL30 gene in Herpes simplex virus type 1 strain 17.


name: DPOL_VZVD DNA polymerase catalytic subunit (sprot)


zilpaterol

mrdef: Is an adrenergic drug currently licensed in Mexico and South Africa as feed additive for cattle close to consignment


name: OPRM_HUMAN Mu-type opioid receptor (sprot)

description: A mu-type opioid receptor that is encoded in the genome of human.


etorphine

mrdef: A narcotic analgesic morphinan used as sedative in veterinary practice


diprenorphine

mrdef: A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered specific antagonist to etorphine


ciramadol

mrdef: benzylamine analgesics; structure given in fourth source


phenazocine

mrdef: An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)


penfluridol

mrdef: One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.


nalorphine

mrdef: A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.


levallorphan

mrdef: An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)


dihydroergocristine

mrdef: A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position of the molecule.

description: Ergocristine in which a single bond replaces the double bond between positions 9 and 10. It is used as the mesylate salt for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease.


α-ergocryptine

mrdef: a component of the ergotoxine complex; it is the main ergot alkaloid of Japanese & South American wid grasses; minor descriptor (76-86); on-line & INDEX MEDICUS search ERGOLINES (76-86); RN given refers to ((5'alpha)-isomer)

description: Ergotaman bearing hydroxy, isopropyl, and 2-methylpropyl groups at the 12', 2' and 5' positions, respectively, and oxo groups at positions 3', 6', and 18. It is a natural ergot alkaloid. Ergocryptine discussed in the literature prior to 1967, when beta-ergocryptine was separated from alpha-ergocryptine, is now referred to as alpha-ergocryptine.


anileridine

mrdef: minor descriptor (64-86); on line & INDEX MEDICUS search ISONIPECOTIC ACIDS (68-86); RN given refers to parent cpd

description: A piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl)ethyl group.


name: DRD1_HUMAN D(1A) dopamine receptor (sprot)

description: A D(1A) dopamine receptor that is encoded in the genome of human.


periciazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.


metergoline

mrdef: A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.

description: An ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.


bromperidol

mrdef: bromine-substituted for chlorine in haloperidol; RN given refers to unlabeled parent cpd; structure


acepromazine

mrdef: Acepromazine, a phenothiazine derivatives, was first used in the 1950s in the treatment of PSYCHOSES. Now, it is commonly used as tranquilizer/sedative agent in dogs, cats, horses, and other animals. It is thought to block dopamine receptors in the brain or inhibit the activity of dopamine in other ways.

description: A member of the class of  phenothiazines that is 10H-phenothiazine substituted by an acetyl group at position 2 and a 3-(dimethylamino)propyl group at position 10.


name: NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (sprot)

description: A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.


name: SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha (sprot)

description: An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human.


name: UROK_HUMAN Urokinase-type plasminogen activator (sprot)

description: A urokinase-type plasminogen activator that is encoded in the genome of human.


silibinin

mrdef: A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.

description: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.


oxfendazole

A member of the class of benzimidazoles that is fenbendazole in which the sulfur has been oxidised to the corresponding sulfoxide.


name: THA_HUMAN Thyroid hormone receptor alpha (sprot)

description: A thyroid hormone receptor alpha that is encoded in the genome of human.


lidoflazine

mrdef: Coronary vasodilator with some antiarrhythmic action.


clebopride

mrdef: antidopaminergic; RN given refers to parent cpd; structure


triparanol

mrdef: Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.


A 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase that is encoded in the genome of human.


trifluperidol

mrdef: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)


name: MDR1_HUMAN ATP-dependent translocase ABCB1 (sprot)

description: An ATP-dependent translocase ABCB1 that is encoded in the genome of human.


daunorubicinol

mrdef: main metabolite of daunomycin

description: The (13S)-diastereomer of 13-dihydrodaunorubicin.


name: SC6A4_HUMAN Sodium-dependent serotonin transporter (sprot)

description: A sodium-dependent serotonin transporter that is encoded in the genome of human.


femoxetine

mrdef: serotonin uptake inhibitor; RN given refers to (3R-trans)-isomer


zimeldine

mrdef: One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)


suloctidil

mrdef: A peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)


nomifensine

mrdef: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)

description: An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively.


iprindole

mrdef: A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257)


ethylestrenol

mrdef: An anabolic steroid with some progestational activity and little androgenic effect.

description: A 17beta-hydroxy steroid that is estrane containing a double bond between positions 4 and 5 and substituted by an ethyl group and a hydroxy group at the 17alpha and 17beta positions, respectively. It is an anabolic steroid that has little androgenic effect and only slight progestational activity. It has been used to promote growth in boys with delayed bone growth.


estradiol benzoate

mrdef: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids

status: OFP

description: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.


name: SC6A2_HUMAN Sodium-dependent noradrenaline transporter (sprot)

description: A sodium-dependent noradrenaline transporter that is encoded in the genome of human.


betanidine

mrdef: A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.


name: 5HT2B_HUMAN 5-hydroxytryptamine receptor 2B (sprot)

description: A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human.


dihydroergocryptine

mrdef: A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position and an alpha-isobutyl sidechain at 5'alpha position of the molecule.

description: alpha-Ergocryptine in which a single bond replaces the double bond between positions 9 and 10.


tirilazad

mrdef: a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; structure given in first source; tradename Freedox


xanomeline

mrdef: a cholinergic agonist; used in the treatment of Alzheimer's disease; structure given in first source


pizotifen

mrdef: Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.

description: A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.


deoxycorticosterone

mrdef: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE

description: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.


indoramin

mrdef: An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.


azaperone

mrdef: A butyrophenone used in the treatment of PSYCHOSES

description: An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.


name: DRD3_HUMAN D(3) dopamine receptor (sprot)

description: A D(3) dopamine receptor that is encoded in the genome of human.


clorotepine

mrdef: major tranquilizer with action similar to those of the phenothiazines; used in schizophrenic & manic psychoses; minor decriptor (77-86); on-line & INDEX MEDICUS search DIBENZOTHIEPINS (77-86); RN given refers to parent cpd without isomeric designation


thioproperazine

A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.


remoxipride

mrdef: An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.


mrdef: an atypical antipsychotic approved in Japan for the treatment of schizophrenia

description: A racemate composed of (2S,3S)- and (2R,3R)-enantiomers of nemonapride. Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.


name: HRH1_HUMAN Histamine H1 receptor (sprot)

description: A histamine H1 receptor that is encoded in the genome of human.


azacyclonol

mrdef: major descriptor (65-84); on-line search PIPERIDINES (65-84); Index Medicus search AZACYCLONOL (65-84); RN given refers to parent cpd


bisulepine

The (Z)-isomer of dithiadene.


name: HRH2_HUMAN Histamine H2 receptor (sprot)

description: A histamine H2 receptor that is encoded in the genome of human.


ebrotidine

mrdef: an H2-receptor antagonist and gastric mucosa protector


name: ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)

description: A muscarinic acetylcholine receptor M1 that is encoded in the genome of human.


sabcomeline

mrdef: selective for M1 receptors; RN refers to (R,S)-isomer


pridinol

mrdef: antispasmodic & muscle relaxant; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7539

description: A piperidine substituted at position 1 by a 3-hydroxy-3,3-diphenylpropyl group.


oxyphenonium

mrdef: A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.


minaprine

mrdef: Agr 1240 refers to di-HCl; short-acting type A MAO inhibitor (MAOI) of mild potency; structure


gallamine

mrdef: A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)


alcuronium

mrdef: A non-depolarizing skeletal muscle relaxant similar to TUBOCURARINE. It is used as an anesthesia adjuvant, for endotracheal intubation and to produce muscle relaxation in general anesthesia during surgical procedures.


name: ACM3_HUMAN Muscarinic acetylcholine receptor M3 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of human.


AOXA_HUMAN Aldehyde oxidase (sprot)

An aldehyde oxidase that is encoded in the genome of human.


name: PBPA_CLOPE Penicillin-binding protein 1A (sprot)


cefacetrile

mrdef: A derivative of 7-aminocephalosporanic acid.


name: PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (sprot)

description: A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A that is encoded in the genome of human.


enoximone

mrdef: A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.


thiamphenicol

mrdef: A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.


name: RL10_HALMA Large ribosomal subunit protein uL10 (sprot)


name: MRP2_HUMAN ATP-binding cassette sub-family C member 2 (sprot)

description: An ATP-binding cassette sub-family C member 2 that is encoded in the genome of human.


name: PBPC_BACSU Penicillin-binding protein 3 (sprot)

description: A protein that is a translation product of the pbpC gene in Bacillus subtilis subsp. subtilis str. 168.


name: GCR_HUMAN Glucocorticoid receptor (sprot)

description: A glucocorticoid receptor that is encoded in the genome of human.


fluprednisolone

mrdef: A synthetic glucocorticoid with anti-inflammatory properties.


ethisterone

mrdef: 17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.

description: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.


dexamethasone palmitate

mrdef: a liposteroid for treatment of hemophagocytic lymphohistiocytosis


ANXA1_HUMAN Annexin A1 (sprot)

An annexin A1 that is encoded in the genome of human.


name: 5HT1B_HUMAN 5-hydroxytryptamine receptor 1B (sprot)

description: A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human.


name: 5HT1D_HUMAN 5-hydroxytryptamine receptor 1D (sprot)

description: A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human.


IL5_HUMAN Interleukin-5 (sprot)

An interleukin-5 that is encoded in the genome of human.


IFNG_HUMAN Interferon gamma (sprot)

An interferon gamma that is encoded in the genome of human.


name: SC6A3_HUMAN Sodium-dependent dopamine transporter (sprot)

description: A sodium-dependent dopamine transporter that is encoded in the genome of human.


CP2D6_HUMAN Cytochrome P450 2D6 (sprot)

A cytochrome P450 2D6 that is encoded in the genome of human.


name: AA1R_HUMAN Adenosine receptor A1 (sprot)

description: An adenosine receptor A1 that is encoded in the genome of human.


etofylline

mrdef: etophyllin appeared once in PubMed: Wien Med Wochenschr. 1986 May 15;136(9):213-8 as a combination drug with theophylline (spelt without e, theophllin)


name: NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (sprot)

description: A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human.


flutrimazole

An imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts.


name: GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2 (sprot)

description: A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human.


name: GBRR2_HUMAN Gamma-aminobutyric acid receptor subunit rho-2 (sprot)

description: A gamma-aminobutyric acid receptor subunit rho-2 that is encoded in the genome of human.


name: DRD4_HUMAN D(4) dopamine receptor (sprot)

description: A D(4) dopamine receptor that is encoded in the genome of human.


name: KCJ11_HUMAN ATP-sensitive inward rectifier potassium channel 11 (sprot)

description: An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human.


name: PARC_ECOLI DNA topoisomerase 4 subunit A (sprot)

description: A DNA topoisomerase 4 subunit A that is encoded in the genome of Escherichia coli K-12.


name: PARC_BACSU DNA topoisomerase 4 subunit A (sprot)


GYRA_MYCTU DNA gyrase subunit A (sprot)

A DNA gyrase subunit A that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


pefloxacin

mrdef: A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.

description: A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.


GYRA_ECOLI DNA gyrase subunit A (sprot)

A DNA gyrase subunit A that is encoded in the genome of Escherichia coli K-12.


fleroxacin

mrdef: A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.

description: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.


BLAT_ECOLX Beta-lactamase TEM (sprot)

A protein that is a translation product of any of the plasmid-encoded copies of the blaTEM gene in Escherichia coli.


corbadrine

description: A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.


emetine

mrdef: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.

description: A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.


name: 5HT3A_HUMAN 5-hydroxytryptamine receptor 3A (sprot)

description: A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human.


octopamine

mrdef: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.

description: A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.


indisetron

mrdef: an anti-emetic agent, indisetron hydrochloride was developed in Japan


azasetron

mrdef: a selective 5-HT3 receptor antagonist; structure given in first source


name: SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 (sprot)

description: A sodium- and chloride-dependent GABA transporter 1 that is encoded in the genome of human.


name: OPRK_HUMAN Kappa-type opioid receptor (sprot)

description: A kappa-type opioid receptor that is encoded in the genome of human.


name: PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (sprot)

description: A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human.


name: DHPS1_MYCLE Dihydropteroate synthase (sprot)

description: A dihydropteroate synthase that is encoded in the genome of Mycobacterium leprae TN.


name: CCG1_HUMAN Voltage-dependent calcium channel gamma-1 subunit (sprot)

description: A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human.


IL4_HUMAN Interleukin-4 (sprot)

An interleukin-4 that is encoded in the genome of human.


name: CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human.


name: TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)

description: A DNA topoisomerase 2-alpha that is encoded in the genome of human.


carubicin

mrdef: A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.

description: A toxic anthracycline antibiotic that is produced by Actinomadura carminata and also has potent antineoplastic activity.


asulacrine

mrdef: derivative of amsacrine; structure given in first source


name: ABCG2_HUMAN Broad substrate specificity ATP-binding cassette transporter ABCG2 (sprot)

description: A broad substrate specificity ATP-binding cassette transporter ABCG2 that is encoded in the genome of human.


name: RS9_ECOLI Small ribosomal subunit protein uS9 (sprot)

description: A prokaryotic-type small ribosomal subunit protein uS9 that is encoded in the genome of Escherichia coli K-12.


name: EMBB_MYCTO Probable arabinosyltransferase B (sprot)


name: EMBC_MYCTU Probable arabinosyltransferase C (sprot)


name: NMD3A_HUMAN Glutamate receptor ionotropic, NMDA 3A (sprot)

description: A glutamate receptor ionotropic, NMDA 3A that is encoded in the genome of human.


name: GLRA1_HUMAN Glycine receptor subunit alpha-1 (sprot)

description: A glycine receptor subunit alpha-1 that is encoded in the genome of human.


picrotin

mrdef: the less toxic component of picrotoxin lacking GABA activity

description: An organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity.


picrotoxin

mrdef: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.

description: A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.


methoxyflurane

mrdef: An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

smiles: COC(F)(F)C(Cl)Cl

description: An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.


fructose

mrdef: A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.

description: A ketohexose that is an isomer of glucose.


name: GLRA2_HUMAN Glycine receptor subunit alpha-2 (sprot)

description: A glycine receptor subunit alpha-2 that is encoded in the genome of human.


γ-linolenic acid

mrdef: An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)

smiles: CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O

description: A C18, omega-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.


name: S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (sprot)

description: A 3-oxo-5-alpha-steroid 4-dehydrogenase 2 that is encoded in the genome of human.


name: CP51_CANAL Lanosterol 14-alpha demethylase (sprot)

description: A protein that is a translation product of the ERG11 gene in Candida albicans SC5314.


TYSY_HUMAN Thymidylate synthase (sprot)

A thymidylate synthase that is encoded in the genome of human.


name: MRP8_HUMAN ATP-binding cassette sub-family C member 11 (sprot)

description: An ATP-binding cassette sub-family C member 11 that is encoded in the genome of human.


name: DPOL_HCMVA DNA polymerase catalytic subunit (sprot)


coumafos

mrdef: A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as nematocide


CAH1_HUMAN Carbonic anhydrase 1 (sprot)

A vertebrate-type carbonic anhydrase 1 that is encoded in the genome of human.


ethyl hydroxybenzoate

An ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol,


paraoxon

mrdef: An organophosphate cholinesterase inhibitor that is used as a pesticide.

description: An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.


gentisic acid

A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.


methyl p-hydroxybenzoate

mrdef: used as a preservative in cosmetics but potentiates UV-induced damage of skin; RN given refers to parent cpd

description: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blueberries.


coumarin

mrdef: effective in reducing edema following crush & thermal injury; structure in Merck Index, 9th ed, #2547; Coumarin itself occurs in the Tonka bean

description: A chromenone having the keto group located at the 2-position.


name: ABCC9_HUMAN ATP-binding cassette sub-family C member 9 (sprot)

description: An ATP-binding cassette sub-family C member 9 that is encoded in the genome of human.


name: KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (sprot)

description: A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human.


name: Q5D1E9_STAAU Penicillin-binding protein 4 (trembl)


biapenem

A carbapenem antibiotic in which the azetidine and pyrroline rings carry 1-hydroxymethyl and pyrazolo[1,2-a][1,2,4]triazolium-6-ylthio substituents respectively.


name: A1KS91_NEIMF Penicillin-binding protein 1A (trembl)


name: PD2R2_HUMAN Prostaglandin D2 receptor 2 (sprot)

description: A prostaglandin D2 receptor DP2 that is encoded in the genome of human.


name: DHRS9_HUMAN Dehydrogenase/reductase SDR family member 9 (sprot)

description: A dehydrogenase/reductase SDR family member 9 that is encoded in the genome of human.


name: RDH5_HUMAN Retinol dehydrogenase 5 (sprot)

description: A retinol dehydrogenase 5 that is encoded in the genome of human.


name: ACH10_HUMAN Neuronal acetylcholine receptor subunit alpha-10 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-10 that is encoded in the genome of human.


pentolonium

mrdef: A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.

description: A dication whose structure comprises a pentane backbone linking two 1-methylpyrrolidinium groups; a nicotinic antagonist used as a ganglionic blocking agent in hypertension.


name: DYR_HUMAN Dihydrofolate reductase (sprot)

description: A dihydrofolate reductase that is encoded in the genome of human.


iclaprim

mrdef: has antiviral activity

description: An aminopyrimidine that is 5-methylpyrimidine-2,4-diamine in which one of the hydrogens of the methyl group has been replaced by a 2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl group.


cycloguanil

mrdef: the active metabolite of proguanil; antifolate drug

description: A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.


name: FOLC_HUMAN Folylpolyglutamate synthase, mitochondrial (sprot)

description: A folylpolyglutamate synthase, mitochondrial that is encoded in the genome of human.


name: DDC_HUMAN Aromatic-L-amino-acid decarboxylase (sprot)

description: An aromatic-L-amino-acid decarboxylase that is encoded in the genome of human.


name: OPRD_HUMAN Delta-type opioid receptor (sprot)

description: A delta-type opioid receptor that is encoded in the genome of human.


name: ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (sprot)

description: An atrial natriuretic peptide receptor 1 that is encoded in the genome of human.


name: SSR2_HUMAN Somatostatin receptor type 2 (sprot)

description: A somatostatin receptor type 2 that is encoded in the genome of human.


somatostatin

mrdef: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

description: A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.


name: SSR5_HUMAN Somatostatin receptor type 5 (sprot)

description: A somatostatin receptor type 5 that is encoded in the genome of human.


name: ABCBB_HUMAN Bile salt export pump (sprot)

description: A bile salt export pump that is encoded in the genome of human.


name: MRP7_HUMAN ATP-binding cassette sub-family C member 10 (sprot)

description: An ATP-binding cassette sub-family C member 10 that is encoded in the genome of human.


name: PTGIS_HUMAN Prostacyclin synthase (sprot)

description: A prostacyclin synthase that is encoded in the genome of human.


oxyphenbutazone

mrdef: A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)

description: A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.


name: DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (sprot)

description: A DNA (cytosine-5)-methyltransferase 3B that is encoded in the genome of human.


name: Q0IJY2_PLAMA Bifunctional dihydrofolate reductase-thymidylate synthase (trembl)


name: DRTS_PLAVI Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


ADK_HUMAN Adenosine kinase (sprot)

An adenosine kinase that is encoded in the genome of human.


name: IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (sprot)

description: An inosine-5'-monophosphate dehydrogenase 1 that is encoded in the genome of human.


M2_I60A0 Matrix protein 2 (sprot)

An influenzavirus matrix protein 2 that is encoded in the genome of the H2N2 strain A/Ann Arbor/6/1960.


name: AOFB_HUMAN Amine oxidase [flavin-containing] B (sprot)

description: An amine oxidase [flavin-containing] B that is encoded in the genome of human.


tioxolone

mrdef: antiseborrheic agent

description: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.


sitosterol

mrdef: used as tranquillizer; sedative; or anticonvulsant; structure

description: A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.


hymecromone

mrdef: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.

description: A hydroxycoumarin that is umbelliferone substituted by a methyl group at position 4.


debrisoquine

mrdef: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.


name: PYRD_PLAF7 Dihydroorotate dehydrogenase (quinone), mitochondrial (sprot)


name: 5HT1F_HUMAN 5-hydroxytryptamine receptor 1F (sprot)

description: A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human.


name: ESR2_HUMAN Estrogen receptor beta (sprot)

description: An estrogen receptor beta that is encoded in the genome of human.


androstenediol

mrdef: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).

description: A 3beta-hydroxy-Delta(5)-steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.


name: VKOR1_HUMAN Vitamin K epoxide reductase complex subunit 1 (sprot)

description: A vitamin K epoxide reductase complex subunit 1 that is encoded in the genome of human.


phenindione

mrdef: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)


ethyl biscoumacetate

mrdef: A coumarin that is used as an anticoagulant. It has actions similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)


POL_HV1A2 Gag-Pol polyprotein (sprot)

A lentivirus-type gag-pol polyprotein that is encoded in the genome of Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2).


DCK_HUMAN Deoxycytidine kinase (sprot)

A deoxycytidine kinase that is encoded in the genome of human.


retigabine

mrdef: It is a first-in-class anticonvulsant that works by activating KCNQ2/3 channels. In vitro studies indicate that ezogabine enhances transmembrane potassium currents mediated by the KCNQ (Kv7.2 to 7.5) family of ion channels. By activating KCNQ channels, ezogabine is thought to stabilize the resting membrane potential and reduce brain excitability.

description: A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An  anticonvulsant used to treat seizures associated with epilepsy in adults.


name: ADCY1_HUMAN Adenylate cyclase type 1 (sprot)

description: An adenylate cyclase type 1 that is encoded in the genome of human.


name: Q60FU1_HAEIF Peptidoglycan D,D-transpeptidase FtsI (trembl)


name: NQO1_HUMAN NAD(P)H dehydrogenase [quinone] 1 (sprot)

description: An NAD(P)H dehydrogenase [quinone] 1 that is encoded in the genome of human.


name: AOFA_HUMAN Amine oxidase [flavin-containing] A (sprot)

description: An amine oxidase [flavin-containing] A that is encoded in the genome of human.


name: ALDR_HUMAN Aldo-keto reductase family 1 member B1 (sprot)

description: An aldo-keto reductase family 1 member B1 that is encoded in the genome of human.


name: NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B (sprot)

description: A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of human.


name: NMDE3_HUMAN Glutamate receptor ionotropic, NMDA 2C (sprot)

description: A glutamate receptor ionotropic, NMDA 2C that is encoded in the genome of human.


name: GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial (sprot)

description: A 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of human.


CAH9_HUMAN Carbonic anhydrase 9 (sprot)

A carbonic anhydrase 9 that is encoded in the genome of human.


name: DPOLA_HUMAN DNA polymerase alpha catalytic subunit (sprot)

description: A DNA polymerase alpha catalytic subunit that is encoded in the genome of human.


ADA_HUMAN Adenosine deaminase (sprot)

An adenosine deaminase that is encoded in the genome of human.


AQP1_HUMAN Aquaporin-1 (sprot)

An aquaporin-1 that is encoded in the genome of human.


TBB5_HUMAN Tubulin beta chain (sprot)

A tubulin beta chain that is encoded in the genome of human.


PLMN_HUMAN Plasminogen (sprot)

A plasminogen that is encoded in the genome of human.


name: LSHR_HUMAN Lutropin-choriogonadotropic hormone receptor (sprot)

description: A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human.


buserelin

mrdef: A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.


name: ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial (sprot)

description: An aldehyde dehydrogenase, mitochondrial that is encoded in the genome of human.


cloprostenol

mrdef: A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle


name: PE2R3_HUMAN Prostaglandin E2 receptor EP3 subtype (sprot)

description: A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human.


fluprostenol

mrdef: Synthetic prostaglandin alpha analog used as an abortifacient

description: An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.


name: GNRHR_HUMAN Gonadotropin-releasing hormone receptor (sprot)

description: A gonadotropin-releasing hormone I receptor that is encoded in the genome of human.


deslorelin

mrdef: Ovuplant is tradename for short-term-release implant containing deslorelin acetate


name: AK1C1_HUMAN Aldo-keto reductase family 1 member C1 (sprot)

description: An aldo-keto reductase family 1 member C1 that is encoded in the genome of human.


name: CPT1A_HUMAN Carnitine O-palmitoyltransferase 1, liver isoform (sprot)

description: A carnitine O-palmitoyltransferase 1, liver isoform that is encoded in the genome of human.


name: DHPS_ECOLI Dihydropteroate synthase (sprot)

description: A dihydropteroate synthase that is encoded in the genome of Escherichia coli K-12.


sulfaphenazole

mrdef: A sulfonilamide anti-infective agent.

description: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.


sulfalene

mrdef: Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.


sulfametoxydiazine

mrdef: Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections.

description: A sulfonamide consisting of pyrimidine having a methoxy substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 2-position.


name: THIL_HUMAN Acetyl-CoA acetyltransferase, mitochondrial (sprot)

description: An acetyl-CoA acetyltransferase, mitochondrial that is encoded in the genome of human.


name: LOX5_HUMAN Polyunsaturated fatty acid 5-lipoxygenase (sprot)

description: A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of human.


PERT_HUMAN Thyroid peroxidase (sprot)

A thyroid peroxidase that is encoded in the genome of human.


name: HPPK_MYCTO 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (sprot)


name: HCAR3_HUMAN Hydroxycarboxylic acid receptor 3 (sprot)

description: A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human.


name: NADC_HUMAN Nicotinate-nucleotide pyrophosphorylase [carboxylating] (sprot)

description: A nicotinate-nucleotide pyrophosphorylase [carboxylating] that is encoded in the genome of human.


CASP1_HUMAN Caspase-1 (sprot)

A caspase-1 that is encoded in the genome of human.


name: RORA_HUMAN Nuclear receptor ROR-alpha (sprot)

description: A nuclear receptor ROR-alpha that is encoded in the genome of human.


name: ABL1_HUMAN Tyrosine-protein kinase ABL1 (sprot)

description: A tyrosine-protein kinase ABL1 that is encoded in the genome of human.


name: KIT_HUMAN Mast/stem cell growth factor receptor Kit (sprot)

description: A mast/stem cell growth factor receptor that is encoded in the genome of human.


niclosamide

mrdef: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). Although suggested as a potential treatment for COVID-19 based on its broad antiviral activity, including in vitro activity against coronaviruses, there are no data to support the use of niclosamide in the treatment of COVID-19.

description: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.


elliptinium

mrdef: synthetic ellipticine deriv; RN given refers to parent cpd; structure given in first source


name: EGFR_HUMAN Epidermal growth factor receptor (sprot)

description: An epidermal growth factor receptor that is encoded in the genome of human.


chromic chloride

mrdef: Trivalent chromium is part of glucose tolerance factor, an activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function.

smiles: Cl[Cr](Cl)Cl


name: TOP1M_HUMAN DNA topoisomerase I, mitochondrial (sprot)

description: A DNA topoisomerase I, mitochondrial that is encoded in the genome of human.


name: PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (sprot)

description: A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human.


stearic acid

smiles: CCCCCCCCCCCCCCCCCC(O)=O

description: A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and  plastics.


docosanoic acid

smiles: CCCCCCCCCCCCCCCCCCCCCC(O)=O

description: A straight-chain, C22, long-chain saturated fatty acid.


oleic acid

mrdef: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)

smiles: CCCCCCCC\C=C/CCCCCCCC(O)=O

description: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.


name: CAH5B_HUMAN Carbonic anhydrase 5B, mitochondrial (sprot)

description: A carbonic anhydrase 5B, mitochondrial that is encoded in the genome of human.


kainic acid

mrdef: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.


name: GRIA1_HUMAN Glutamate receptor 1 (sprot)

description: A glutamate receptor 1 that is encoded in the genome of human.


cyclothiazide

mrdef: inhibits the desensitization of AMPA-type receptors; structure

description: 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema.


name: PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)

description: A cGMP-specific 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.


sulmazole

An imidazopyridine that is 1H-imidazo[4,5-b]pyridine which is substituted at position 2 by a 2-methoxy-4-(methylsulfinyl)phenyl group. An A1 adenosine receptor antagonist, it was formerly used as a cardiotonic agent.


name: PDE6A_HUMAN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (sprot)

description: A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha that is encoded in the genome of human.


name: RXRA_HUMAN Retinoic acid receptor RXR-alpha (sprot)

description: A retinoic acid receptor RXR-alpha that is encoded in the genome of human.


name: RXRB_HUMAN Retinoic acid receptor RXR-beta (sprot)

description: A retinoic acid receptor RXR-beta that is encoded in the genome of human.


name: RXRG_HUMAN Retinoic acid receptor RXR-gamma (sprot)

description: A retinoic acid receptor RXR-gamma that is encoded in the genome of human.


name: Q53I07_9HIV1 Env polyprotein (Fragment) (trembl)


name: PDE11_HUMAN Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (sprot)

description: A dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A that is encoded in the genome of human.


name: PDE1A_HUMAN Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A that is encoded in the genome of human.


name: ADT2_HUMAN ADP/ATP translocase 2 (sprot)

description: An ADP/ATP translocase 2 that is encoded in the genome of human.


name: ADT1_HUMAN ADP/ATP translocase 1 (sprot)

description: An ADP/ATP translocase 1 that is encoded in the genome of human.


name: ADT3_HUMAN ADP/ATP translocase 3 (sprot)

description: An ADP/ATP translocase 3 that is encoded in the genome of human.


name: PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 1 that is encoded in the genome of human.


trypan blue

mrdef: A diazo-naphthalene sulfonate that is widely used as a stain.

description: An aminonaphthalenesulfonic acid that is the free acid form of trypan blue dye.


name: CP17A_HUMAN Steroid 17-alpha-hydroxylase/17,20 lyase (sprot)

description: A cytochrome P450 17A1 that is encoded in the genome of human.


isoconazole

A racemate comprising equimolar amounts of (R)- and (S)-isoconazole. A broad-spectrum antibacterial drug used (as its nitrate salt) for treatment of dermatomycoses.


bifonazole

A racemate comprising equimolar amounts of R- and S-bifonazole. It is a broad spectrum antifungal drug used for the treatment of fungal skin and nail infections.


name: RARG_HUMAN Retinoic acid receptor gamma (sprot)

description: A retinoic acid receptor gamma that is encoded in the genome of human.


name: CP27B_HUMAN 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (sprot)

description: A 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial that is encoded in the genome of human.


arbutin

A monosaccharide derivative that is  hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.


TYRO_HUMAN Tyrosinase (sprot)

A tyrosinase that is encoded in the genome of human.


name: RIR1_HHV11 Ribonucleoside-diphosphate reductase large subunit (sprot)


OXYR_HUMAN Oxytocin receptor (sprot)

An oxytocin receptor that is encoded in the genome of human.


name: MTOR_HUMAN Serine/threonine-protein kinase mTOR (sprot)

description: A serine/threonine-protein kinase mTOR that is encoded in the genome of human.


ridaforolimus

mrdef: an mTOR inhibitor for the treatment of cancer


name: ADX_HUMAN Adrenodoxin, mitochondrial (sprot)

description: An adrenodoxin, mitochondrial that is encoded in the genome of human.


amprolium

mrdef: A veterinary coccidiostat that interferes with THIAMINE metabolism

description: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.


name: S19A2_HUMAN Thiamine transporter 1 (sprot)

description: A thiamine transporter 1 that is encoded in the genome of human.


TKT_HUMAN Transketolase (sprot)

A transketolase that is encoded in the genome of human.


name: RET7_HUMAN Retinoid-binding protein 7 (sprot)

description: A retinoid-binding protein 7 that is encoded in the genome of human.


name: AL1A1_HUMAN Aldehyde dehydrogenase 1A1 (sprot)

description: An aldehyde dehydrogenase 1A1 that is encoded in the genome of human.


name: RLBP1_HUMAN Retinaldehyde-binding protein 1 (sprot)

description: A retinaldehyde-binding protein 1 that is encoded in the genome of human.


name: PDE4A_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4A (sprot)

description: A 3',5'-cyclic-AMP phosphodiesterase 4A that is encoded in the genome of human.


name: O54286_STAAU Beta-lactam-inducible penicillin-binding protein (trembl)


name: Q14TG6_HAEIF Peptidoglycan D,D-transpeptidase FtsI (trembl)


name: LIPP_HUMAN Pancreatic triacylglycerol lipase (sprot)

description: A pancreatic triacylglycerol lipase that is encoded in the genome of human.


name: MURA2_ENTFA UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (sprot)


name: Q54906_STRPY Penicillin-binding protein (trembl)


name: SYFA_ECOLI Phenylalanine--tRNA ligase alpha subunit (sprot)

description: A prokaryotic-type phenylalanine--tRNA ligase alpha subunit that is encoded in the genome of Escherichia coli K-12.


name: PE2R2_HUMAN Prostaglandin E2 receptor EP2 subtype (sprot)

description: A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human.


rioprostil

mrdef: A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.


MGA_HUMAN Maltase-glucoamylase (sprot)

A maltase-glucoamylase that is encoded in the genome of human.


name: UCK1_HUMAN Uridine-cytidine kinase 1 (sprot)

description: A uridine-cytidine kinase 1 that is encoded in the genome of human.


albendazole sulfoxide

mrdef: Albendazole oxide (also known as albendazole sulphoxide and ricobendazole) is a benzimidazole with a broad-spectrum anthelmintic used in veterinary medicine. It is also a metabolite of two other veterinary drugs: netobimin and albendazole. The mechanism of action of ricobendazole (albendazole sulfoxide), ensuring its anthelmintic activity, is associated with selective inhibition of beta-tubulin polymerization. It binds to the colchicine site of tubulin, inhibiting microtubule polymerization. It also exhibits anticancer activity, potentiating the effects of taxanes and inhibiting cell proliferation in breast cancer cells, non-small cell lung cancer (NSCLC) cells, and melanoma cells. Also, albendazole oxide has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting the cell cycle at the G2/M phase.


STS_HUMAN Steryl-sulfatase (sprot)

A steryl-sulfatase that is encoded in the genome of human.


name: SHBG_HUMAN Sex hormone-binding globulin (sprot)

description: A sex hormone-binding globulin that is encoded in the genome of human.


mesterolone

mrdef: 17 beta-Hydroxy-1 alpha-methyl-5 alpha-androstan-3-one. A synthetic steroid with anabolic and androgenic activities.


mestanolone

mrdef: non-virilizing androgenic steroid; RN given refers to (5alpha,17beta)-isomer; structure


pregnenolone succinate

mrdef: A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.


gestrinone

mrdef: A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.


androstenedione

mrdef: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.

description: A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.


aldosterone

mrdef: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.

description: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


name: O96529_MELIC Carboxylic ester hydrolase (trembl)


name: PSMD1_HUMAN 26S proteasome non-ATPase regulatory subunit 1 (sprot)

description: A 26S proteasome non-ATPase regulatory subunit 1 that is encoded in the genome of human.


name: CCR5_HUMAN C-C chemokine receptor type 5 (sprot)

description: A C-C chemokine receptor type 5 that is encoded in the genome of human.


name: S2512_HUMAN Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (sprot)

description: An electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial that is encoded in the genome of human.


name: AATC_HUMAN Aspartate aminotransferase, cytoplasmic (sprot)

description: An aspartate aminotransferase, cytoplasmic that is encoded in the genome of human.


ACY2_HUMAN Aspartoacylase (sprot)

An aspartoacylase that is encoded in the genome of human.


name: ASNS_HUMAN Asparagine synthetase [glutamine-hydrolyzing] (sprot)

description: An asparagine synthetase [glutamine-hydrolyzing] that is encoded in the genome of human.


name: ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase (sprot)

description: An aspartyl/asparaginyl beta-hydroxylase that is encoded in the genome of human.


name: DHE3_HUMAN Glutamate dehydrogenase 1, mitochondrial (sprot)

description: A glutamate dehydrogenase 1, mitochondrial that is encoded in the genome of human.


name: CEGT_HUMAN Ceramide glucosyltransferase (sprot)

description: A ceramide glucosyltransferase that is encoded in the genome of human.


name: BCL2_HUMAN Apoptosis regulator Bcl-2 (sprot)

description: An apoptosis regulator Bcl-2 that is encoded in the genome of human.


name: IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (sprot)

description: An inosine-5'-monophosphate dehydrogenase 2 that is encoded in the genome of human.


name: PD2R_HUMAN Prostaglandin D2 receptor (sprot)

description: A prostaglandin D2 receptor that is encoded in the genome of human.


name: SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (sprot)

description: A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human.


name: FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (sprot)

description: A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human.


name: RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (sprot)

description: A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human.


TRY1_HUMAN Serine protease 1 (sprot)

A serine protease 1 that is encoded in the genome of human.


name: DPP4_HUMAN Dipeptidyl peptidase 4 (sprot)

description: A dipeptidyl peptidase 4 that is encoded in the genome of human.


hesperetin

mrdef: aglycone of HESPERIDIN; structure

description: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.


name: HPRT_HUMAN Hypoxanthine-guanine phosphoribosyltransferase (sprot)

description: A hypoxanthine-guanine phosphoribosyltransferase that is encoded in the genome of human.


fendosal

A benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity.


name: PAI1_HUMAN Plasminogen activator inhibitor 1 (sprot)

description: A plasminogen activator inhibitor 1 that is encoded in the genome of human.


name: S22A6_HUMAN Solute carrier family 22 member 6 (sprot)

description: A solute carrier family 22 member 6 that is encoded in the genome of human.


name: S22A8_HUMAN Organic anion transporter 3 (sprot)

description: An organic anion transporter 3 that is encoded in the genome of human.


loxiglumide

mrdef: cholecystokinin receptor antagonist; RN refers to (+-)-isomer


dexloxiglumide

mrdef: a CCK receptor antagonist; structure given in first source


name: GGT1_HUMAN Glutathione hydrolase 1 proenzyme (sprot)

description: A glutathione hydrolase 1 proenzyme that is encoded in the genome of human.


name: GLRB_HUMAN Glycine receptor subunit beta (sprot)

description: A glycine receptor subunit beta that is encoded in the genome of human.


name: TNNC1_HUMAN Troponin C, slow skeletal and cardiac muscles (sprot)

description: A troponin C, slow skeletal and cardiac muscles that is encoded in the genome of human.


name: MMP2_HUMAN 72 kDa type IV collagenase (sprot)

description: A 72 kDa type IV collagenase that is encoded in the genome of human.


KLK1_HUMAN Kallikrein-1 (sprot)

A kallikrein-1 that is encoded in the genome of human.


name: SSDH_HUMAN Succinate-semialdehyde dehydrogenase, mitochondrial (sprot)

description: A succinate-semialdehyde dehydrogenase, mitochondrial that is encoded in the genome of human.


AMPN_HUMAN Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of human.


CASP3_HUMAN Caspase-3 (sprot)

A caspase-3 that is encoded in the genome of human.


name: PCP_HUMAN Lysosomal Pro-X carboxypeptidase (sprot)

description: A lysosomal Pro-X carboxypeptidase that is encoded in the genome of human.


name: PHKG2_HUMAN Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (sprot)

description: A phosphorylase b kinase gamma catalytic chain, liver/testis isoform that is encoded in the genome of human.


name: HDAC5_HUMAN Histone deacetylase 5 (sprot)

description: A histone deacetylase 5 that is encoded in the genome of human.


name: FABP4_HUMAN Fatty acid-binding protein, adipocyte (sprot)

description: A fatty acid-binding protein, adipocyte that is encoded in the genome of human.


name: CDK1_HUMAN Cyclin-dependent kinase 1 (sprot)

description: A cyclin-dependent kinase 1 that is encoded in the genome of human.


TOP1_HUMAN DNA topoisomerase 1 (sprot)

A type 1B DNA topoisomerase 1 that is encoded in the genome of human.


name: HDAC2_HUMAN Histone deacetylase 2 (sprot)

description: A histone deacetylase 2 that is encoded in the genome of human.


name: CXCR4_HUMAN C-X-C chemokine receptor type 4 (sprot)

description: A C-X-C chemokine receptor type 4 that is encoded in the genome of human.


name: PIM1_HUMAN Serine/threonine-protein kinase pim-1 (sprot)

description: A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human.


proglumide

mrdef: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

description: A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.


pentagastrin

mrdef: A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.


name: IGF1R_HUMAN Insulin-like growth factor 1 receptor (sprot)

description: An insulin-like growth factor 1 receptor that is encoded in the genome of human.


name: 3BHS1_HUMAN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (sprot)

description: A 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 that is encoded in the genome of human.


name: GBA1_HUMAN Lysosomal acid glucosylceramidase (sprot)

description: A lysosomal acid glucosylceramidase that is encoded in the genome of human.


name: HNMT_HUMAN Histamine N-methyltransferase (sprot)

description: A histamine N-methyltransferase that is encoded in the genome of human.


name: HDAC3_HUMAN Histone deacetylase 3 (sprot)

description: A histone deacetylase 3 that is encoded in the genome of human.


MTLR_HUMAN Motilin receptor (sprot)

A motilin receptor that is encoded in the genome of human.


RYR1_HUMAN Ryanodine receptor 1 (sprot)

A ryanodine receptor 1 that is encoded in the genome of human.


name: ACHE_HUMAN Acetylcholine receptor subunit epsilon (sprot)

description: An acetylcholine receptor subunit epsilon that is encoded in the genome of human.


anisindione

mrdef: a synthetic anticoagulant it exercises its therapeutic action by reducing the prothrombin activity of the blood by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins

description: A cyclic beta-diketone consisting of indane-1,3-dione having a 4-methoxyphenyl substituent at the 4-position.


name: VKGC_HUMAN Vitamin K-dependent gamma-carboxylase (sprot)

description: A vitamin K-dependent gamma-carboxylase that is encoded in the genome of human.


OPRX_HUMAN Nociceptin receptor (sprot)

A nociceptin receptor that is encoded in the genome of human.


TLR9_HUMAN Toll-like receptor 9 (sprot)

A Toll-like receptor 9 that is encoded in the genome of human.


CYB_PLAFA Cytochrome b (sprot)

A protein that is a translation product of the MT-CYB gene in Plasmodium falciparum.


name: TPA_HUMAN Tissue-type plasminogen activator (sprot)

description: A tissue-type plasminogen activator that is encoded in the genome of human.


ELNE_HUMAN Neutrophil elastase (sprot)

A neutrophil elastase that is encoded in the genome of human.


name: HDAC7_HUMAN Histone deacetylase 7 (sprot)

description: A histone deacetylase 7 that is encoded in the genome of human.


name: FGFR3_HUMAN Fibroblast growth factor receptor 3 (sprot)

description: A fibroblast growth factor receptor 3 that is encoded in the genome of human.


name: C11B2_HUMAN Cytochrome P450 11B2, mitochondrial (sprot)

description: A cytochrome P450 11B that is a translation product of the CYP11B2 gene in human.


fadrozole

mrdef: A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.


name: LOX15_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX15 (sprot)

description: A polyunsaturated fatty acid lipoxygenase ALOX15 that is encoded in the genome of human.


MMP3_HUMAN Stromelysin-1 (sprot)

A stromelysin-1 that is encoded in the genome of human.


name: PLK1_HUMAN Serine/threonine-protein kinase PLK1 (sprot)

description: A serine/threonine-protein kinase PLK1 that is encoded in the genome of human.


name: GRIK5_HUMAN Glutamate receptor ionotropic, kainate 5 (sprot)

description: A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of human.


name: PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (sprot)

description: A cGMP-dependent 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.


name: GRM5_HUMAN Metabotropic glutamate receptor 5 (sprot)

description: A metabotropic glutamate receptor 5 that is encoded in the genome of human.


L-serine-O-phosphate

mrdef: The phosphoric acid ester of serine.

description: The L-enantiomer of O-phosphoserine.


name: GRM4_HUMAN Metabotropic glutamate receptor 4 (sprot)

description: A metabotropic glutamate receptor 4 that is encoded in the genome of human.


name: MK10_HUMAN Mitogen-activated protein kinase 10 (sprot)

description: A mitogen-activated protein kinase 10 that is encoded in the genome of human.


name: SYYC_HUMAN Tyrosine--tRNA ligase, cytoplasmic (sprot)

description: A tyrosine--tRNA ligase, cytoplasmic that is encoded in the genome of human.


name: DAPK2_HUMAN Death-associated protein kinase 2 (sprot)

description: A death-associated protein kinase 2 that is encoded in the genome of human.


name: DHB1_HUMAN 17-beta-hydroxysteroid dehydrogenase type 1 (sprot)

description: A 17-beta-hydroxysteroid dehydrogenase type 1 that is encoded in the genome of human.


FDFT_HUMAN Squalene synthase (sprot)

A squalene synthase that is encoded in the genome of human.


name: KPCD_HUMAN Protein kinase C delta type (sprot)

description: A protein kinase C delta type that is encoded in the genome of human.


name: ROCK2_HUMAN Rho-associated protein kinase 2 (sprot)

description: A Rho-associated protein kinase 2 that is encoded in the genome of human.


name: KPCA_HUMAN Protein kinase C alpha type (sprot)

description: A protein kinase C alpha type that is encoded in the genome of human.


name: KSYK_HUMAN Tyrosine-protein kinase SYK (sprot)

description: A tyrosine-protein kinase SYK that is encoded in the genome of human.


name: DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP(+)] (sprot)

description: A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human.


PPCE_HUMAN Prolyl endopeptidase (sprot)

A prolyl endopeptidase that is encoded in the genome of human.


name: MYLK2_HUMAN Myosin light chain kinase 2, skeletal/cardiac muscle (sprot)

description: A myosin light chain kinase 2, skeletal/cardiac muscle that is encoded in the genome of human.


name: SOAT1_HUMAN Sterol O-acyltransferase 1 (sprot)

description: A sterol O-acyltransferase 1 that is encoded in the genome of human.


name: CSK_HUMAN Tyrosine-protein kinase CSK (sprot)

description: A tyrosine-protein kinase CSK that is encoded in the genome of human.


CATD_HUMAN Cathepsin D (sprot)

A cathepsin D that is encoded in the genome of human.


name: LYAG_HUMAN Lysosomal alpha-glucosidase (sprot)

description: A lysosomal alpha-glucosidase that is encoded in the genome of human.


CATG_HUMAN Cathepsin G (sprot)

A cathepsin G that is encoded in the genome of human.


CATB_HUMAN Cathepsin B (sprot)

A cathepsin B that is encoded in the genome of human.


nitroxoline

A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.


name: TIE2_HUMAN Angiopoietin-1 receptor (sprot)

description: An angiopoietin-1 receptor that is encoded in the genome of human.


name: EPHA8_HUMAN Ephrin type-A receptor 8 (sprot)

description: An ephrin type-A receptor 8 that is encoded in the genome of human.


name: GRIK3_HUMAN Glutamate receptor ionotropic, kainate 3 (sprot)

description: A glutamate receptor ionotropic, kainate 3 that is encoded in the genome of human.


name: KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit gamma (sprot)

description: A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human.


name: AAK1_HUMAN AP2-associated protein kinase 1 (sprot)

description: An AAK1 gene translation product (human), isoforms h1 and h2.


name: MARK2_HUMAN Serine/threonine-protein kinase MARK2 (sprot)

description: A serine/threonine-protein kinase MARK2 that is encoded in the genome of human.


name: LOX12_HUMAN Polyunsaturated fatty acid lipoxygenase ALOX12 (sprot)

description: A polyunsaturated fatty acid lipoxygenase ALOX12 that is encoded in the genome of human.


name: MET_HUMAN Hepatocyte growth factor receptor (sprot)

description: A hepatocyte growth factor receptor that is encoded in the genome of human.


name: BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (sprot)

description: A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of human.


LIMK1_HUMAN LIM domain kinase 1 (sprot)

A LIM domain kinase 1 that is encoded in the genome of human.


name: KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 (sprot)

description: A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human.


CP2J2_HUMAN Cytochrome P450 2J2 (sprot)

A cytochrome P450 2J2 that is encoded in the genome of human.


CMA1_HUMAN Chymase (sprot)

A chymase that is encoded in the genome of human.


name: FABP5_HUMAN Fatty acid-binding protein 5 (sprot)

description: A fatty acid-binding protein 5 that is encoded in the genome of human.


name: MMP14_HUMAN Matrix metalloproteinase-14 (sprot)

description: A matrix metalloproteinase-14 that is encoded in the genome of human.


name: GSTP1_HUMAN Glutathione S-transferase P (sprot)

description: A glutathione S-transferase P that is encoded in the genome of human.


name: FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP4 that is encoded in the genome of human.


name: CDK5_HUMAN Cyclin-dependent kinase 5 (sprot)

description: A cyclin-dependent kinase 5 that is encoded in the genome of human.


name: ST17B_HUMAN Serine/threonine-protein kinase 17B (sprot)

description: A serine/threonine-protein kinase 17B that is encoded in the genome of human.


name: STK10_HUMAN Serine/threonine-protein kinase 10 (sprot)

description: A serine/threonine-protein kinase 10 that is encoded in the genome of human.


RENI_CALJA Renin (sprot)

A renin that is encoded in the genome of Callithrix jacchus.


HMOX2_RAT Heme oxygenase 2 (sprot)

A heme oxygenase 2 that is encoded in the genome of rat.


name: Q33BM1_RAT G protein-coupled receptor GPR35 (trembl)


name: GPR35_MOUSE G-protein coupled receptor 35 (sprot)

description: A G-protein coupled receptor 35 that is encoded in the genome of mouse.


name: GSHR_PLAF7 Glutathione reductase (sprot)


name: KPCE_HUMAN Protein kinase C epsilon type (sprot)

description: A protein kinase C epsilon that is encoded in the genome of human.


AURKC_HUMAN Aurora kinase C (sprot)

An aurora kinase C that is encoded in the genome of human.


name: PDE9A_HUMAN High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (sprot)

description: A high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A that is encoded in the genome of human.


name: KCNN3_HUMAN Small conductance calcium-activated potassium channel protein 3 (sprot)

description: A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human.


name: EPHA5_HUMAN Ephrin type-A receptor 5 (sprot)

description: An ephrin type-A receptor 5 that is encoded in the genome of human.


name: EPHA4_HUMAN Ephrin type-A receptor 4 (sprot)

description: An ephrin type-A receptor 4 that is encoded in the genome of human.


name: FA7_HUMAN Coagulation factor VII (sprot)

description: A coagulation factor VII that is encoded in the genome of human.


name: HDAC9_HUMAN Histone deacetylase 9 (sprot)

description: A histone deacetylase 9 that is encoded in the genome of human.


name: ERR2_HUMAN Steroid hormone receptor ERR2 (sprot)

description: A steroid hormone receptor ERR2 that is encoded in the genome of human.


name: GRM7_HUMAN Metabotropic glutamate receptor 7 (sprot)

description: A metabotropic glutamate receptor 7 that is encoded in the genome of human.


name: GSTA1_HUMAN Glutathione S-transferase A1 (sprot)

description: A glutathione S-transferase A1 that is encoded in the genome of human.


name: PKN1_HUMAN Serine/threonine-protein kinase N1 (sprot)

description: A serine/threonine-protein kinase N1 that is encoded in the genome of human.


name: MK03_HUMAN Mitogen-activated protein kinase 3 (sprot)

description: A mitogen-activated protein kinase 3 that is encoded in the genome of human.


name: ST17A_HUMAN Serine/threonine-protein kinase 17A (sprot)

description: A serine/threonine-protein kinase 17A that is encoded in the genome of human.


name: TNIK_HUMAN TRAF2 and NCK-interacting protein kinase (sprot)

description: A TRAF2 and NCK-interacting protein kinase that is encoded in the genome of human.


name: SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (sprot)

description: An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of human.


name: I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 (sprot)

description: An indoleamine 2,3-dioxygenase 1 that is encoded in the genome of human.


enilconazole

A racemate comprising equimolar amounts of (R)- and (S)-enilconazole. A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals. In veterinary medicine, it is used topically for the treatment of fungal skin infections in cattle, dogs, and horses; it is also used by inhalation for the treatment of aspergillosis in ostriches.


name: DGLA_HUMAN Diacylglycerol lipase-alpha (sprot)

description: A diacylglycerol lipase-alpha that is encoded in the genome of human.


name: SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (sprot)

description: An NAD-dependent protein deacetylase sirtuin-2 that is encoded in the genome of human.


name: DPP8_HUMAN Dipeptidyl peptidase 8 (sprot)

description: A dipeptidyl peptidase 8 that is encoded in the genome of human.


AURKA_HUMAN Aurora kinase A (sprot)

An aurora kinase A that is encoded in the genome of human.


name: ALK_HUMAN ALK tyrosine kinase receptor (sprot)

description: An ALK tyrosine kinase receptor that is encoded in the genome of human.


name: KCNN2_HUMAN Small conductance calcium-activated potassium channel protein 2 (sprot)

description: A small conductance calcium-activated potassium channel protein 2 that is encoded in the genome of human.


name: BMP2K_HUMAN BMP-2-inducible protein kinase (sprot)

description: A BMP-2-inducible protein kinase that is encoded in the genome of human.


name: MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (sprot)

description: An induced myeloid leukemia cell differentiation protein Mcl-1 that is encoded in the genome of human.


name: C1R_HUMAN Complement C1r subcomponent (sprot)

description: A complement C1r subcomponent that is encoded in the genome of human.


MMP13_HUMAN Collagenase 3 (sprot)

A collagenase 3 that is encoded in the genome of human.


name: FABPI_HUMAN Fatty acid-binding protein, intestinal (sprot)

description: A fatty acid-binding protein, intestinal that is encoded in the genome of human.


name: CLK2_HUMAN Dual specificity protein kinase CLK2 (sprot)

description: A dual specificity protein kinase CLK2 that is encoded in the genome of human.


name: CLK3_HUMAN Dual specificity protein kinase CLK3 (sprot)

description: A dual specificity protein kinase CLK3 that is encoded in the genome of human.


name: GGPPS_HUMAN Geranylgeranyl pyrophosphate synthase (sprot)

description: A geranylgeranyl pyrophosphate synthase that is encoded in the genome of human.


name: M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (sprot)

description: A mitogen-activated protein kinase kinase kinase 4 that is encoded in the genome of human.


name: DPP9_HUMAN Dipeptidyl peptidase 9 (sprot)

description: A dipeptidyl peptidase 9 that is encoded in the genome of human.


CTRB1_HUMAN Chymotrypsinogen B (sprot)

A chymotrypsinogen B that is encoded in the genome of human.


BACE1_HUMAN Beta-secretase 1 (sprot)

A beta-secretase 1 that is encoded in the genome of human.


name: RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (sprot)

description: A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human.


name: FOLR2_HUMAN Folate receptor beta (sprot)

description: A folate receptor beta that is encoded in the genome of human.


name: KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase type 1D (sprot)

description: A calcium/calmodulin-dependent protein kinase type 1D that is encoded in the genome of human.


name: STK4_HUMAN Serine/threonine-protein kinase 4 (sprot)

description: A serine/threonine-protein kinase 4 that is encoded in the genome of human.


name: DHI1_HUMAN 11-beta-hydroxysteroid dehydrogenase 1 (sprot)

description: An 11-beta-hydroxysteroid dehydrogenase 1 that is encoded in the genome of human.


glycyrrhizin

mrdef: A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.

description: A  triterpenoid saponin that is the  glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.


name: GRM6_HUMAN Metabotropic glutamate receptor 6 (sprot)

description: A metabotropic glutamate receptor 6 that is encoded in the genome of human.


name: EPHA7_HUMAN Ephrin type-A receptor 7 (sprot)

description: An ephrin type-A receptor 7 that is encoded in the genome of human.


name: KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (sprot)

description: A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human.


name: AL5AP_HUMAN Arachidonate 5-lipoxygenase-activating protein (sprot)

description: An arachidonate 5-lipoxygenase-activating protein that is encoded in the genome of human.


name: CAC1F_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1F (sprot)

description: A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human.


name: ANM1_HUMAN Protein arginine N-methyltransferase 1 (sprot)

description: A protein arginine N-methyltransferase 1 that is encoded in the genome of human.


name: KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase kinase 1 (sprot)

description: A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human.


name: G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase (sprot)

description: A glucose-6-phosphate 1-dehydrogenase that is encoded in the genome of human.


polydatin

mrdef: from Polygonum cuspidatum

description: A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.


name: EPHB4_HUMAN Ephrin type-B receptor 4 (sprot)

description: An ephrin type-B receptor 4 that is encoded in the genome of human.


name: GPBAR_HUMAN G-protein coupled bile acid receptor 1 (sprot)

description: A G-protein coupled bile acid receptor 1 that is encoded in the genome of human.


name: TSSK1_HUMAN Testis-specific serine/threonine-protein kinase 1 (sprot)

description: A testis-specific serine/threonine-protein kinase 1 that is encoded in the genome of human.


1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.


name: PSB8_HUMAN Proteasome subunit beta type-8 (sprot)

description: A proteasome subunit beta type-8 that is encoded in the genome of human.


name: NK3R_HUMAN Neuromedin-K receptor (sprot)

description: A neuromedin-K receptor that is encoded in the genome of human.


name: ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 (sprot)

description: A phospholipid-transporting ATPase ABCA1 that is encoded in the genome of human.


name: AOC1_HUMAN Diamine oxidase [copper-containing] (sprot)

description: An amiloride-sensitive amine oxidase [copper-containing] that is encoded in the genome of human.


name: ASIC1_HUMAN Acid-sensing ion channel 1 (sprot)

description: An acid-sensing ion channel 1 that is encoded in the genome of human.


name: ACV1B_HUMAN Activin receptor type-1B (sprot)

description: An activin receptor type-1B that is encoded in the genome of human.


name: ACVR1_HUMAN Activin receptor type-1 (sprot)

description: An activin receptor type-1 that is encoded in the genome of human.


name: ALDR_PIG Aldo-keto reductase family 1 member B1 (sprot)

description: A protein that is a translation product of the AKR1B1 gene in pig.


name: MAP2_HUMAN Methionine aminopeptidase 2 (sprot)

description: A methionine aminopeptidase 2 that is encoded in the genome of human.


fumagillin

mrdef: empirical formula C25-27H34-37O7, a monoester of decatetraenedioic acid (HOOC-(C=CH)4-COOH and fumagillin (C16-17H25-26O3); FR 65814 lacks the fat

description: A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.


mibolerone

mrdef: prevents estrus in animals prevents experimental lymphoid leukosis

description: An androgen that is nalandrone carrying two methyl substituents at positions 7alpha and 17.


ANDR_RAT Androgen receptor (sprot)

An androgen receptor that is encoded in the genome of rat.


clofenotane

mrdef: synthetic insecticide used to combat malaria, typhus, and the other insect-borne human diseases

description: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.


promegestone

mrdef: A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.

description: A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.


name: APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (sprot)

description: A DNA-(apurinic or apyrimidinic site) endonuclease that is encoded in the genome of human.


lucanthone

mrdef: One of the SCHISTOSOMICIDES, it has been replaced largely by HYCANTHONE and more recently PRAZIQUANTEL. (From Martindale The Extrapharmacopoeia, 30th ed., p46)

description: A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.


hycanthone

mrdef: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.

description: A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.


name: ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (sprot)

description: A beta-adrenergic receptor kinase 1 that is encoded in the genome of human.


cefsulodin

mrdef: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.

description: A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic.


name: CA2D2_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-2 (sprot)

description: A voltage-dependent calcium channel subunit alpha-2/delta-2 that is encoded in the genome of human.


name: CAT_SALTI Chloramphenicol acetyltransferase (sprot)


name: CDK15_HUMAN Cyclin-dependent kinase 15 (sprot)

description: A cyclin-dependent kinase 15 that is encoded in the genome of human.


name: CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (sprot)

description: A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of human.


name: CLCKA_HUMAN Chloride channel protein ClC-Ka (sprot)

description: A chloride channel protein ClC-Ka that is encoded in the genome of human.


name: CLCN2_HUMAN Chloride channel protein 2 (sprot)

description: A chloride channel protein 2 that is encoded in the genome of human.


gestodene

mrdef: synthetic steroid with progestational activity; RN given refers to (17alpha)-isomer


name: DRTS_PLABA Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


name: DRTS_PLAFK Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


name: EAA2_HUMAN Excitatory amino acid transporter 2 (sprot)

description: An excitatory amino acid transporter 2 that is encoded in the genome of human.


name: EAA3_HUMAN Excitatory amino acid transporter 3 (sprot)

description: An excitatory amino acid transporter 3 that is encoded in the genome of human.


name: GLRA3_HUMAN Glycine receptor subunit alpha-3 (sprot)

description: A glycine receptor subunit alpha-3 that is encoded in the genome of human.


GRIA2_RAT Glutamate receptor 2 (sprot)

A glutamate receptor 2 that is encoded in the genome of rat.


name: GRIA3_HUMAN Glutamate receptor 3 (sprot)

description: A glutamate receptor 3 that is encoded in the genome of human.


name: GRM3_HUMAN Metabotropic glutamate receptor 3 (sprot)

description: A metabotropic glutamate receptor 3 that is encoded in the genome of human.


name: GRM8_HUMAN Metabotropic glutamate receptor 8 (sprot)

description: A metabotropic glutamate receptor 8 that is encoded in the genome of human.


name: GSTK1_HUMAN Glutathione S-transferase kappa 1 (sprot)

description: A glutathione S-transferase kappa 1 that is encoded in the genome of human.


name: HYES_HUMAN Bifunctional epoxide hydrolase 2 (sprot)

description: An epoxide hydrolase 2 that is encoded in the genome of human.


sodium lauryl sulfate

An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.