name: Grade 4 Scrotum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Leukemia Secondary To Oncology Chemotherapy, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Death


name: Grade 3 Alkaline Phosphatase Increased, CTCAE

description: >5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal


Grade 2 Euphoria, CTCAE

description: Moderate mood elevation


Nutritional Calcium Deficient Rickets

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Nutritional rickets due to dietary deficiency of calcium.


name: Grade 3 Lung Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Hypogonadotropic Hypogonadism with Adrenal Hypoplasia Congenita

description: Hypogonadotropic hypogonadism with congenital adrenal hypoplasia associated with mutation(s) in the NR0B1 gene (on the X chromosome).


name: Pleura Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Adult Atypical Meningioma

description: An atypical meningioma that occurs during adulthood.


Grade 5 Hyperkalemia, CTCAE

description: Death


Grade 3 Hypokalemia, CTCAE

description: <3.0-2.5 mmol/L; hospitalization indicated


Neurological ventriculitis

description: Inflammation of a cerebral ventricle.


Grade 4 Lung Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


IgM Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgM monoclonal immunoglobulin in the blood or urine.


name: Stage IIIB Esophageal Adenocarcinoma AJCC v7

description: Stage IIIB includes: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Grade 1 Pancreatic Duct Intra-Operative Injury, CTCAE


name: Grade 4 Small Bowel Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Radiating Chest Pain Along Right Upper Sternal Border

description: The location of the radiating chest pain is along the right upper sternal border.


Death Related to Adverse Event

description: The termination of life associated with an adverse event.


Obstructed Megaureter

description: A megaureter in which there is obstruction to the flow of urine at the ureterovesical junction.


Grade 3 Uterine Fistula, CTCAE

description: Invasive intervention indicated


name: Secondary Graft Failure After Hematopoietic Cell Transplantation

description: Loss of donor hematopoietic cells following initial engraftment.


Hindgut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the sigmoid colon, descending colon, or rectum.


name: Grade 4 Cranial Nerve IX Sensory Intra-Operative Injury, CTCAE


Grade 4 Colonic Ulcer, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Abdominal Distension, CTCAE

description: A disorder characterized by swelling of the abdomen.


name: Locally Advanced Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Grade 1 Lingual Nerve Intra-Operative Injury, CTCAE


Bone Marrow Hypocellular, CTCAE

description: A disorder characterized by the inability of the bone marrow to produce hematopoietic elements.


Hypoproteinemia

description: A laboratory test result indicating abnormally low levels of total protein in the serum.


Infusion Related Adverse Event

description: An adverse event that can be related to an infusion.


CTCAE v4 Grade 1

description: An adverse event that is asymptomatic; or involves mild or minor symptoms; or is of marginal clinical relevance; or consists of clinical or diagnostic observations alone; or for which intervention is not indicated; or for which only non-prescription intervention is indicated.


name: Spinal Cord Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Stage II Centroblastic Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Grade 5 Suicide Attempt, CTCAE

description: Death


Extrahepatic bile duct cancer stage II

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the liver, gallbladder, pancreas, and/or unilateral branches or the portal vein (right or left) or hepatic artery (right or left).  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Grade 2 Lymph Node Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Breast hyperplasia

description: A general term that refers to hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, usual ductal hyperplasia, columnar cell hyperplasia, and atypical lobular hyperplasia.


Testicular Cystic Trophoblastic Tumor

description: A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


name: Grade 2 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Grade 5 Neonatal Sinus Bradycardia, AE

description: A sinus bradycardia adverse event in a newborn which results in death.


Blood Gonadotrophin Abnormal, CTCAE

description: A finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen.


Injury To Inferior Vena Cava, CTCAE

description: A finding of damage to the inferior vena cava.


Genitourinary Signs and Symptoms

description: Patient complaints (symptoms), physical or laboratory findings (signs) related to the genitourinary system.


name: Cranial Nerve III Intra-Operative Injury, CTCAE


Grade 3 Optic Nerve Disorder, CTCAE

description: Marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200)


Grade 4 Cardiac Arrest, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Grade 2 Small Bowel Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Personality and Behavioral Change, CTCAE


name: Grade 1 Colon Intra-Operative Injury, CTCAE


name: Grade 2 Urinary Tract Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


Nickel Metabolic Disorder

description: A storage disorder that results from impaired metabolism of nickel.


name: Recurrent Polymorphous Low Grade Neuroepithelial Tumor of the Young

description: The reemergence of polymorphous low-grade neuroepithelial tumor of the young after a period of remission.


Grade 3 Hypernatremia, CTCAE

description: >155-160 mmol/L; hospitalization indicated


Grade 1 Alopecia, CTCAE

description: Hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage


Passive Smoke Exposure

description: Exposure to tobacco smoke products among individuals who do not smoke. This can result from sharing space with a smoker or from placental transfer from mother to fetus.


name: Rectum Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Rectal Ulcer, CTCAE

description: Symptomatic; altered GI function (e.g., altered dietary habits, vomiting, diarrhea)


Malignant neoplasm of bladder recurrent

description: The reemergence of a malignant bladder neoplasm after a period of remission.


name: Grade 5 Esophagus Infection with Unknown Absolute Neutrophil Count, CTCAE


Gastrointestinal carcinoma in situ

description: An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion.


Urostomy Prolapse

description: Displacement of the urostomy.


Lumbar Meningocele

description: A congenital abnormality in the lumbar region of the spine in which the meninges protrude through a defect in the spinal column.


name: Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Grade 4 Bone Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Venous Injury, CTCAE

description: Symptomatic (e.g., claudication); repair or revision not indicated


name: Clinical Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Unresectable Genitourinary System Carcinoma

description: Genitourinary system carcinoma that is not amenable to surgical resection.


Primary Cutaneous Mucinous Carcinoma

description: A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology).


name: Unresectable Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that is not amenable to surgical resection.


Grade 2 Colonic Perforation, CTCAE

description: Invasive intervention not indicated


name: Grade 5 Small Intestinal Mucositis, CTCAE

description: Death


Grade 2 Pharyngeal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


Lupus encephalitis

description: Encephalitis that is associated with systemic lupus erythematosus.


Childhood depression

description: Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide.


Adult Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during adulthood.


name: Grade 5 Radiation Excluding Chemoradiation, CTCAE


Grade 3 Ovarian Rupture, CTCAE

description: Transfusion; invasive intervention indicated


Stage IIB Esophageal Carcinoma

description: Stage IIB includes: For squamous cell carcinoma: (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


name: Grade 5 Right Ventricular Dysfunction, CTCAE

description: Death


Ovarian Rupture, CTCAE

description: A disorder characterized by tearing or disruption of the ovarian tissue.


Congenital spondylolysis

description: Spondylolysis, the cause of which is present from birth.


Grade 3 Folliculitis, CTCAE

description: >30% BSA; systemic intervention indicated


name: Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified

description: Acute leukemia of ambiguous lineage, expressing combinations of markers that do not allow for its classification as either acute undifferentiated leukemia or mixed phenotype acute leukemia, and definitive classification along a single lineage is difficult. (WHO 2017)


name: Vascular Disorders - Other, Specify, CTCAE


Unresectable Esophageal Carcinoma

description: A carcinoma that arises from the esophagus and is not amenable to surgical resection.


Papillary mucinous cystadenocarcinoma

description: An invasive adenocarcinoma characterized by cystic changes, papillary growth pattern, and the presence of malignant glandular cells which contain intracytoplasmic mucin.


name: Metastatic Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites.


Gastric Hepatoid Adenocarcinoma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of large polygonal malignant cells with eosinophilic cytoplasm resembling hepatocytes.


Anal squamous cell carcinoma metastatic

description: Anal squamous cell carcinoma that has spread from its primary site to another anatomic site.


name: Recurrent Endometrial Clear Cell Adenocarcinoma

description: The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


Bone Sarcoma by AJCC v7 Stage

description: A term that refers to the staging of bone sarcoma, following the rules of the TNM AJCC v7 classification system.


CTRP Clinical Finding

description: A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


Pulmonary Hypertension, CTCAE

description: A disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder.


name: Recurrent Large Cell Neuroendocrine Carcinoma

description: The reemergence of large cell neuroendocrine carcinoma after a period of remission.


name: Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Hydrocephalus, CTCAE

description: A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain.


Diffuse neurofibroma

description: A rare neurofibroma with an infiltrative growth pattern.  It involves the skin and subcutaneous tissue and grows in a plaque-like fashion.  Malignant transformation is rare.


Gastric Carcinoma with Lymphoid Stroma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures.


Grade 2 Prostatic Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified

description: A myelodysplastic/myeloproliferative neoplasm that does not meet the criteria of other myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes, and myeloproliferative neoplasms. It is associated with cytopenia, blasts less than 20% in bone marrow and peripheral blood, thrombocytosis, and absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.


Naevus spider acquired

description: A non-congenital, benign vascular lesion with a central punctum (arteriole) that is surrounded by thin-walled capillaries in a radial pattern. It occurs as the result of the dilatation of pre-existing vessels and is most often an incidental finding. The lesion may also be found in association with hypermetabolic states or chronic disease.


name: Metastatic Malignant Neoplasm in the Pelvic Cavity

description: The spread of a malignant neoplasm from a primary site to the pelvic cavity.


Hypertension, CTCAE

description: A disorder characterized by a pathological increase in blood pressure.


Grade 4 Papilledema, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


name: Childhood Acute Lymphoblastic Leukemia CNS-Negative Toronto Guidelines v2

description: No clinical signs of CNS involvement and no blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Acute Undifferentiated Leukemia

description: Acute undifferentiated leukemia that does not respond to treatment.


Stage IV Urethral Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: For male penile urethra and female urethra: Tumor invades other adjacent organs (e.g., invasion of the bladder wall). For prostatic urethra: Tumor invades other adjacent organs (e.g., extraprostatic invasion of the bladder wall, rectal wall). N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. N2: Multiple regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Grade 4 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Movements Involuntary, CTCAE

description: Severe symptoms; limiting self care ADL


Grade 2 Duodenal Fistula, CTCAE

description: Symptomatic, invasive intervention not indicated


name: Skin disorder arising from mental factors

description: A skin disorder for which mental factors play a causative role.


Aleukemic myeloid leukemia

description: Myeloid leukemia presenting with leukemic infiltration of tissues and normal or decreased leukocyte count in the peripheral blood.


Virus-Related Carcinoma

description: Carcinoma that develops in the context of an individual infected with a virus.


Vulvar Melanocytic Nevus

description: A benign, atypical, or dysplastic melanocytic nevus that arises from the vulva.


Enterotoxigenic E coli Infection

description: A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 10-72 hours and a duration of 1-5 days. Symptoms may include acute, occasionally severe diarrhea without fever.


Skin Lesion 15-200 mm

description: A skin lesion that measures between 15 and 200 mm in greatest dimension.


Radiculitis, CTCAE

description: A disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root.


name: Grade 5 Neuroendocrine Prolactin Hormone Secretion Abnormality, CTCAE


Grade 3 Accessory Nerve Disorder, CTCAE

description: Severe symptoms; limiting self care ADL


Grade 1 Proctitis, CTCAE

description: Rectal discomfort, intervention not indicated


Grade 2 Pelvic Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


name: Complete Atrioventricular Canal Defect Balanced

description: Atrioventricular septal defect in which the atrioventricular junction is shared evenly between the left ventricle and right ventricle.


name: Grade 1 Other Metabolic and Laboratory, CTCAE


Benign Liver Non-Epithelial Neoplasm

description: A non-epithelial neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hemangioma, angiomyolipoma, and solitary fibrous tumor.


Cognitive Disturbance, CTCAE 5.0

description: A disorder characterized by a conspicuous change in cognitive function.


Gastrointestinal Stoma Necrosis, CTCAE

description: A disorder characterized by a necrotic process occurring in the gastrointestinal tract stoma.


Endometrioid intraepithelial neoplasia

description: A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations.


High Leukocyte Count

description: A higher than average level of leukocytes in a sample.


name: AIDS-Related Malignant Cervical Neoplasm

description: A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Pericarditis secondary to uremia

description: Inflammation of the pericardium associated with chronic kidney failure.


name: Grade 1 Nasopharynx Intra-Operative Injury, CTCAE


Refractory Chronic Leukemia

description: Chronic leukemia that is resistant to treatment.


Grade 4 Endocarditis Infective, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Adverse Event Associated with Constitutional Symptoms


Testicular cancer metastatic

description: A malignant germ cell tumor that arises from the testis and has spread to another anatomic site.


name: Non-Functioning Pancreatic Neuroendocrine Tumor G1

description: A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.


name: Grade 3 Carbon Monoxide Diffusion Capacity, CTCAE


Urostomy Leak, CTCAE

description: A finding of leakage of contents from a urostomy.


name: Childhood Connective and Soft Tissue Neoplasm

description: A soft tissue or bone neoplasm that occurs during childhood.


name: Arterial Thrombosis Related to Vascular Access Complication

description: The formation of a thrombus in the artery as a direct result of an activity associated with vascular access.


name: Lugano Classification Stage I Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Malignant Osteoclastic Giant Cell-Rich Tumor of Bone

description: A giant cell tumor that arises from the bone and is characterized by the presence of a malignant cellular component.


Neonatal Hypotension, AE

description: An adverse event in a newborn characterized by abnormally low blood pressure, which is usually symptomatic.


name: Refractory Sclerodermatous Graft Versus Host Disease

description: Sclerodermatous Graft Versus Host Disease that is resistant to treatment.


name: Grade 4 Cranial Nerve VII Sensory Intra-Operative Injury, CTCAE


Grade 1 Photophobia, CTCAE

description: Symptomatic but not limiting ADL


Infectious Encephalomyelitis

description: An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses.


Acral nevus

description: A melanocytic nevus that arises from the palms, soles, and nails.


name: Early T Precursor Acute Lymphoblastic Leukemia with BCL11B Rearrangement

description: An early T precursor acute lymphoblastic leukemia associated with the presence of BCL11B gene rearrangement.


Grade 1 Vaginal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


Grade 5 Arachnoiditis, CTCAE

description: Death


name: Grade 3 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Stage IIA2 Cervical Cancer AJCC v8

description: Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Acute Myeloid Leukemia with STAG2 Mutation

description: An acute myeloid leukemia associated with STAG2 gene mutation.


name: Cranial Nerve X Intra-Operative Injury, CTCAE


Liver Germ Cell Tumor

description: A benign or malignant extragonadal germ cell tumor that arises from the liver. Representative examples include teratoma and yolk sac tumor.


Loss of INI 1 Protein Expression

description: An immunohistochemical finding indicating negative staining of tumor cells for INI 1 protein, resulting from the inactivation of the INI 1 tumor suppressor gene.


Grade 2 Dysesthesia, CTCAE

description: Moderate sensory alteration; limiting instrumental ADL


Grade 2 Bronchopulmonary Dysplasia, AE

description: An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for 22-30% oxygen at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for 22-30% oxygen by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for 22-30% oxygen at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.


name: Refractory Fallopian Tube Mucinous Adenocarcinoma

description: Fallopian tube mucinous adenocarcinoma that is resistant to treatment.


Grade 3 Prolapse of Urostomy, CTCAE

description: Dysfunctional stoma; elective operative intervention or major stomal revision indicated


name: Borrelia Burgdoferi-Associated Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: Primary cutaneous marginal zone lymphoproliferative disorder that arises from chronically stimulated lymphoid tissue in the skin in response to Borrelia burgdoferi infection.


Indirect Contact Transmission Infection

description: Infection transmitted by water, food or other means of conveyance.


Interstitial Disease

description: A disease occurring chiefly in the connective-tissue framework of an organ.


name: Grade 4 Peritoneal Cavity Intra-Operative Injury, CTCAE


Grade 1 Neonatal Fever, AE

description: An adverse event in a newborn characterized by isolated, not sustained fever, no change in baseline age-appropriate behavior.


name: Grade 3 Breast Volume and Hypoplasia, CTCAE


Adolescent Gynecomastia

description: Gynecomastia that occurs during puberty and is not due to exogenous substances or disease processes.


name: Anal Canal Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of anal canal cancer according to the American Joint Committee on Cancer, 6th and 7th editions. This staging system applies to carcinomas arising in the anal canal only; melanomas, carcinoid tumors, sarcomas, and perianal tumors are not included. (from AJCC 6th and 7th Eds.)


Grade 5 Perforation Bile Duct, CTCAE

description: Death


name: Chest Pain in Right Fifth Intercostal Space

description: The location of the chest pain is within the fifth intercostal space on the right side.


Mural Nodule

description: A solid, sharply demarcated, benign or malignant nodular mass that is attached to the wall of an organ.


Renal lymphocele

description: Encapsulated collection of lymphatic fluid around a transplanted kidney.


Periorbital Infection, CTCAE

description: A disorder characterized by an infectious process involving the orbit of the eye.


name: Refractory T Acute Lymphoblastic Leukemia

description: T-acute lymphoblastic leukemia that does not respond to treatment.


Metastatic Acral Lentiginous Melanoma

description: Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site.


Unresectable Solid Neoplasm

description: A solid neoplasm that is not amenable to surgical resection.


name: Grade 2 Penis Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 5 Testicular Hemorrhage, CTCAE

description: Death


Radiation burn

description: A burn caused by exposure to x-ray, radium, sunlight, atomic or any other type of radiant energy.


Grade 2 Skin Ulceration, CTCAE

description: Combined area of ulcers 1-2 cm; partial thickness skin loss involving skin or subcutaneous fat


name: Grade 3 Abdominal Distension or Bloating, CTCAE


name: Human Papillomavirus-Related Vaginal Adenocarcinoma

description: An adenocarcinoma that arises from the vagina and is caused by human papillomavirus infection.


name: Recurrent HIV-Related Lymphoproliferative Disorder

description: The reemergence of HIV-associated lymphoproliferative disorder after a period of remission.


name: Testicular Spermatocytic Tumor with Sarcoma

description: A malignant germ cell tumor that arises from the testis and is characterized by the presence of a spermatocytic tumor component that is contiguous with an undifferentiated or differentiated sarcomatous component.  It usually presents as a slowly growing mass that enlarges very rapidly soon after the initial diagnosis.


Myocardial Infarction, CTCAE

description: A disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area.


Toxic Epidermal Necrolysis, CTCAE

description: A disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.


name: Metastatic Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


name: Progesterone Receptor-Positive Malignant Neoplasm

description: A malignant neoplasm that is positive for progesterone receptors.


Rhinorrhea, CTCAE

description: A disorder characterized by excessive mucous secretions draining from the nose.


name: Locally Advanced Digestive System Carcinoma

description: Digestive system carcinoma that has spread to nearby tissues or lymph nodes.


Grade 1 Gastroparesis, CTCAE

description: Mild nausea, early satiety and bloating, able to maintain caloric intake on regular diet


Arterial Thromboembolism, CTCAE

description: A disorder characterized by occlusion of an arterial vessel by a blood clot that develops in an artery.


name: Grade 5 Anus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 3 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 2 Bacteremia, CTCAE

description: Blood culture positive with no signs or symptoms


name: Grade 4 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Metastatic Benign Neoplasm

description: A very rare benign neoplasm that metastasizes inexplicably. This category includes metastasizing pleomorphic adenoma of the salivary gland and uterine corpus metastasizing leiomyoma.


Grade 3 Urostomy Site Bleeding, CTCAE

description: Transfusion indicated; invasive intervention indicated


name: Refractory Low Grade Fallopian Tube Serous Adenocarcinoma

description: Low grade fallopian tube serous adenocarcinoma that is resistant to treatment.


name: Grade 4 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Refractory Malignant Urinary System Neoplasm

description: Malignant urinary system neoplasm that is resistant to treatment.


name: Grade 1 Superior Vena Cava Vein Injury, CTCAE


name: Grade 2 Retina Intra-Operative Injury, CTCAE


name: Grade 4 Biliary Tree NOS Intra-Operative Injury, CTCAE


Grade 2 Hematoma, CTCAE

description: Minimally invasive evacuation or aspiration indicated


name: Grade 5 Bronchus Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Adrenal Gland Intra-Operative Injury, CTCAE


Signet Ring Melanoma

description: A rare variant of cutaneous melanoma, characterized by the presence of malignant cells with signet-ring morphology.


Junctional melanocytic nevus of skin

description: A nevus characterized by the presence of an intraepidermal proliferation of nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. It presents as a small, slightly raised, pigmented skin lesion.


Mucosal lentiginous melanoma

description: An acral lentiginous melanoma affecting mucosal surfaces.


name: Grade 2 Foreign Body Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Dental-Tooth Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Chemically Induced Irreversible Toxicity


name: Grade 5 Peristomal Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 5 Stomach Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: Grade 3 Kidney Infection with Unknown Absolute Neutrophil Count, CTCAE


Childhood Junctional Nevus

description: A junctional nevus that occurs during childhood.


Adult Grade III Meningioma

description: A grade III meningioma that occurs during adulthood.


Grade 4 Infective Myositis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Colon Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade I Meningioma

description: A benign meningioma which may recur in approximately 7-20% of the cases.  This category includes the angiomatous meningioma, fibrous meningioma, lymphoplasmacyte-rich meningioma, meningothelial meningioma, metaplastic meningioma, microcystic meningioma, psammomatous meningioma, secretory meningioma, and transitional meningioma.


Stage II Vulvar Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Grade 5 Ureter Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 4 Watering Eyes, CTCAE

description: Best corrected visual acuity of 20/200 or worse in the affected eye


Phantom Limb Syndrome

description: Paresthesia or discomfort experienced post-amputation.


Recurrent Laryngeal Nerve Paralysis

description: Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis.


name: Grade 2 Lip or Perioral Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Tracheal Stenosis, CTCAE

description: Symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental ADL


name: Recurrent Central Nervous System Lymphoma

description: The reemergence of central nervous system lymphoma after a period of remission.


name: Grade 2 Jejunum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Heart Intra-Operative Injury, CTCAE


Esophageal Ulcer, CTCAE

description: A disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the esophageal wall.


Grade 3 INR Increased, CTCAE

description: >2.5; >2.5 x baseline if on anticoagulation; bleeding


Kidney Paraganglioma

description: An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category.


name: Digestive System Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: High Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of masses of mucin within the affected distended glands.


name: Grade 1 Otitis External Ear Non Infectious, CTCAE


name: Stage M0 Childhood Ependymoma by Toronto Guidelines v2

description: No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Grade 2 Lower Extremity Artery Injury, CTCAE


Malignant neoplasm of stomach recurrent

description: The reemergence of a malignant neoplasm of the stomach after a period of remission.


Stage I Cervical Cancer AJCC v8

description: Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


Blastic Granulocytic Sarcoma

description: A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001).


Childhood NUT Carcinoma

description: A NUT carcinoma that occurs during childhood.


name: Lobular Endocervical Glandular Hyperplasia

description: Lobular proliferations of benign-appearing small to moderate sized endocervical glands in the inner half of the cervical stroma. The glands are lined by columnar epithelial cells which contain pyloric gland-type mucin. There is minimal atypia and mitotic figures are rare. Some cases have been associated with adenocarcinoma in situ/high grade cervical glandular intraepithelial neoplasia and gastric-type adenocarcinomas.


name: Grade 4 Duodenum Intra-Operative Injury, CTCAE


Paratesticular Serous Cystadenoma

description: A rare serous cystadenoma that arises from the paratesticular structures.


name: Grade 3 Genitourinary Stoma Prolapse, CTCAE


Grade 1 Toothache, CTCAE

description: Mild pain


name: Grade 3 Stenosis of Gastrointestinal Stoma, CTCAE

description: Severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated


Grade 1 Ovarian Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Clonal Cytopenia with Monocytosis of Undetermined Significance

description: A myelodysplastic/myeloproliferative neoplasm that fulfills the diagnostic criteria of clonal monocytosis of undetermined significance and is associated with cytopenia.


Ventricular Tachycardia, CTCAE 5.0

description: A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His.


name: Grade 1 Scleral Necrosis and Melt, CTCAE


Stage II Pancreatic Cancer AJCC v8

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Pituitary hemorrhage

description: Bleeding within the pituitary gland.


Radiation-Related Osteosarcoma

description: A high grade osteosarcoma arising in an irradiated bone.


recurrent adult acute myeloid leukemia

description: The reemergence of acute myeloid leukemia in adults after a period of remission.


name: No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Pancreatic Intraductal Neoplasms

description: A group of cystic or mass-forming epithelial neoplasms that arise from the exocrine pancreas, exhibit ductal differentiation, and grow mostly within the pancreatic ducts.  This group includes the pancreatic intraductal papillary mucinous neoplasms and the pancreatic intraductal tubulopapillary neoplasms.


name: Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Great vessel abnormalities

description: A congenital vascular abnormality that affects the great vessels and/or aortic arch. Representative examples include double aortic arch, aortic coarctation, and absence of a pulmonary artery.


name: Grade 1 Neutrophil Count Decreased, CTCAE

description: <LLN-1500/mm3; <LLN-1.5 x 10e9/L


Stage I Appendix Carcinoma AJCC v7

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Radiation-Induced Vascular Disease

description: A vascular disease caused by radiation.


Grade 3 Colonic Ulcer, CTCAE

description: Severely altered GI function; TPN indicated; elective invasive intervention indicated


name: Metastatic Sarcomatoid Urothelial Carcinoma

description: Sarcomatoid urothelial carcinoma that has spread to another anatomical site.


name: Grade 3 Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 4 Ejection Fraction Decreased, CTCAE

description: Resting ejection fraction (EF) <20%


Second degree perineal laceration

description: Injury to perineum involving perineal muscles but not involving anal sphincter. (reVITALize)


name: Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Hypertriglyceridemia, CTCAE

description: A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood.


name: Grade 5 Genitourinary Stoma Stricture or Stenosis, CTCAE


name: Grade 3 Lens Intra-Operative Injury, CTCAE


Recurrent Gangliocytoma

description: The reemergence of gangliocytoma after a period of remission.


Low Weight Gain in Pregnancy

description: In a woman with a normal weight pre-pregnancy body mass index (BMI), i.e. 18.5-24.9, the weight gained during pregnancy does not exceed a total weight gain of 25 lbs. In a woman with an underweight pre-pregnancy body mass index (BMI), i.e. less than 18.5, the weight gained during pregnancy does not exceed a total weight gain of 28 lbs. In a woman with an overweight pre-pregnancy body mass index (BMI), i.e. 25.0-29.9, the weight gained during pregnancy does not exceed a total weight gain of 15 lbs. In a woman with an obese pre-pregnancy body mass index (BMI), i.e. greater than 30, the weight gained during pregnancy does not exceed a total weight gain of 11 lbs. These standards are supported for the whole population irrespective of height, race or ethnicity.


Gallbladder Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The Ki-67 index is higher than 20%.


name: Blood coagulation disorder due to liver disease

description: A disorder of blood clotting that is attributable to a deficiency in liver function.


Atrial Fibrillation, CTCAE

description: A disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles.


Pathological Gynecomastia

description: Gynecomastia that is due to exogenous substances or disease processes.


Grade 1 Uveitis, CTCAE

description: Anterior uveitis with trace cells


Pedunculated conjunctival papilloma

description: A papilloma that arises from the conjunctival squamous epithelium. It is associated with human papillomavirus infection.


Benign Intracranial Neoplasm

description: A neoplasm that involves the intracranial area and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Grade 2 Obstruction Gastric, CTCAE

description: Symptomatic; altered GI function; limiting instrumental ADL


Dysphagia, CTCAE

description: A disorder characterized by difficulty in swallowing.


Neonatal Coagulation Disorder, AE

description: An adverse event in a newborn characterized by abnormal blood clotting or bleeding.


Grade 4 Duodenal Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: Anal or Perianal Infection with Unknown Absolute Neutrophil Count, CTCAE


Chronic Insomnia

description: Insomnia that has persisted at least one month.


Grade 1 Libido Decreased, CTCAE

description: Decrease in sexual interest not adversely affecting relationship


Grade 5 Stevens-Johnson Syndrome, CTCAE

description: Death


New Onset Diabetes After Transplant

description: Development of diabetes after transplant, usually associated with calcineurin inhibitor use.


name: Grade 4 Other Allergy and Immunology, CTCAE


Localized Prostate Carcinoma

description: A carcinoma that arises from the prostate and has not spread to other anatomic sites.


name: Benign Ovarian Partly Luteinized Thecoma


name: Metastatic Malignant Nongerminomatous Germ Cell Tumor

description: A malignant nongerminomatous germ cell tumor that has spread from its original site of growth to another anatomic site.


name: Grade 1 Associated with the Teeth, CTCAE


Recurrent Meningioma

description: The reemergence of a meningioma after a period of remission.


Grade 2 Abdominal Infection, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Upper Gastrointestinal Hemorrhage NOS, CTCAE


Well Differentiated Malignant Neoplasm

description: A malignant neoplasm with morphological features reminiscent of the tissue from which it arose.


Grade 2 Atelectasis, CTCAE

description: Symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning


name: Ampulla of Vater Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


name: Grade 5 Nasal Cavity and Paranasal Sinus Reactions, CTCAE


name: Grade 2 Upper Extremity Intra-Operative Injury, CTCAE


name: Grade 2 Biliary Tree Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Ovarian Leydig Cell Hyperplasia

description: An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020)


name: Grade 4 Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Stomach Intra-Operative Injury, CTCAE


name: Grade 5 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Cardiac Troponin T Increased, CTCAE

description: Levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer


name: Grade 3 External Ear Infection with Unknown Absolute Neutrophil Count, CTCAE


Stage IV Merkel Cell Carcinoma AJCC v7

description: Stage IV includes: Any T, Any N, M1.  M1: Metastasis beyond regional lymph nodes. (AJCC 7th Ed.)


Stage 0 Anal Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade squamous intraepithelial lesion (previously termed carcinoma in situ, Bowen disease, anal intraepithelial neoplasia II-III, high-grade anal intraepithelial neoplasia). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Endometrial Carcinoma

description: A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


Grade 5 Prostate Infection, CTCAE

description: Death


Grade 2 Irritability, CTCAE

description: Moderate; limiting instrumental ADL; increased attention indicated


Grade 3 Soft Tissue Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


Grade 1 Hyperglycemia, CTCAE

description: Abnormal glucose above baseline with no medical intervention


name: Salivary Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Cranial Nerve X Intra-Operative Injury, CTCAE


Grade 1 Glucosuria, CTCAE

description: Present


name: Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma


name: Grade 3 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 2 Tremor, CTCAE

description: Moderate symptoms; limiting instrumental ADL


Digestive System Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


Refractory Skin Squamous Cell Carcinoma

description: Skin squamous cell carcinoma that does not respond to treatment.


name: Simple Hamartoma of the Retinal Pigment Epithelium

description: A retinal hamartoma that involves only the retinal pigment epithelium. (WHO 2018)


Acute Myeloid Leukemia with del(17p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 17 [del(17p)].


mCode Non-Neoplastic Disease/Finding

description: Terminology related to non-neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


name: Extragonadal primary germ cell tumor mixed stage II


Refractory Myxoid Liposarcoma

description: Myxoid liposarcoma that does not respond to treatment.


name: Esophageal Adenocarcinoma by AJCC v7 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Grade 5 Delusions, CTCAE

description: Death


Subcutaneous Disorder

description: A disorder of the subcutaneous tissue.


name: Undersocialized conduct disorder, aggressive type


name: Locally Advanced Biliary Tract Carcinoma

description: Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread to nearby tissues or lymph nodes.


name: Radiating Chest Pain Along Left Midclavicular Line

description: The location of the radiating chest pain is along the left midclavicular line.


name: Refractory Endometrial Transitional Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


Recurrent Appendix Carcinoma

description: The reemergence of appendix carcinoma after a period of remission.


Kidney Schwannoma

description: A rare schwannoma arising from the kidney.


name: Grade 4 Postoperative Thoracic Procedure Complication, CTCAE

description: Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)


Treatment-Emergent Adverse Event

description: A situation that emerges during treatment, having been absent pretreatment, or worsens relative to the pretreatment state. (ICH)


Childhood Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that occurs during childhood.


Congenital complete heart block

description: A disorder characterized by an electrocardiographic finding of a complete atrioventricular block that manifests during fetal life or soon after birth. It may be isolated or associated with other congenital heart defects. Isolated congenital complete atrioventricular block may be associated with maternal connective tissue disorders.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 2

description: Dyskeratosis congenita caused by mutation(s) in the TERT gene, encoding telomerase reverse transcriptase.


name: Appendix Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


name: Grade 1 CD4 Lymphocytes Decreased, CTCAE

description: <LLN-500/mm3; <LLN-0.5 x 10e9/L


name: Lugano Classification Stage IE Childhood Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


name: Grade 4 Wound Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 2 Vital Capacity Abnormal, CTCAE

description: <75-50% of predicted value; limiting instrumental ADL


Metaplastic meningioma

description: A WHO grade I meningioma characterized by the presence of a prominent mesenchymal component. The mesenchymal component may be osseous, cartilaginous, myxoid, lipomatous, or a mixture of mesenchymal elements.


name: Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Bone Cancer AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


name: Small Bowel Infection with Unknown Absolute Neutrophil Count NOS, CTCAE


Grade 5 Meningismus, CTCAE

description: Death


name: Grade 5 Ileum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 3 Obstruction Gastric, CTCAE

description: Hospitalization indicated; invasive intervention indicated; limiting self care ADL


name: Decreased Carbon Monoxide Diffusing Capacity

description: A lung function test result in which the lung capacity to absorb carbon monoxide is decreased.


Grade 3 Anal Necrosis, CTCAE

description: TPN or hospitalization indicated; invasive intervention indicated


Childhood Blue Nevus

description: A blue nevus that occurs during childhood.


Grade 5 Hyponatremia, CTCAE

description: Death


name: Grade 2 Surgical and Medical Procedures - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


Joint Tuberculosis

description: Tuberculosis affecting a joint.


name: Grade 4 Other Blood and Bone Marrow, CTCAE


Ureter Cancer by AJCC v7 Stage

description: A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 7th edition.


name: Grade 5 Fallopian Tube Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Elevated WT1

description: A finding indicating elevated concentrations of WT1 in a sample.


Epidermal burn of skin

description: A painful injury to the epidermis due to chemical, friction, radiation or thermal exposure. The affected area appears red and blanches when touched.


Grade 5 Capillary Leak Syndrome, CTCAE

description: Death


Foregut Neuroendocrine Tumor G1

description: A neuroendocrine tumor that arises from the esophagus, stomach, or duodenum.


Radiating Chest Pain in Left Arm

description: The location of the radiating chest pain is in the left arm.


Stage IIIA Gallbladder Cancer AJCC v7

description: Stage IIIA includes: T3, N0, M0. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Polycythaemia (excl rubra vera)

description: An increase in the concentration of red blood cells (hemoglobin) that is not caused by polycythemia vera.


name: Grade 5 Stomach Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 2 Other Blood and Bone Marrow, CTCAE


name: Stage IIIC Uterine Corpus Cancer AJCC v8

description: Stage IIIC includes: IIIC1: T1-T3, N1/N1mi/N1a, M0; IIIC2: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Grade 5 Ventricular Arrhythmia, CTCAE

description: Death


description: Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections.


Corneal dellen

description: Corneal thinning just anterior to the limbus secondary to abnormal and/or irregular bulbar conjunctival contour.


name: Chest Pain in Left Fourth Intercostal Space

description: The location of the chest pain is within the fourth intercostal space on the left side.


Spindle cell melanoma, type B

description: A melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. Representative example is the type B spindle cell uveal melanoma.


name: Grade 1 Soft Tissue NOS Intra-Operative Injury, CTCAE


name: Esophageal Adenocarcinoma by AJCC v8 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


name: asymptomatic carrier of alpha-thalassemia

description: A condition in which a person has reduced protein production from one of the four alpha-globin alleles.


Stage IIIC Cervical Cancer FIGO 2018

description: Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


name: Grade 2 Breast Intra-Operative Injury, CTCAE


Recurrent Severe Aplastic Anemia

description: The reemergence of severe aplastic anemia after a period of remission.


name: Recurrent Pancreatic Neuroendocrine Carcinoma

description: The reemergence of pancreatic neuroendocrine carcinoma after a period of remission.


Grade 2 Genital Edema, CTCAE

description: Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour


name: Grade 4 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Renal and Urinary Disorders - Other, Specify, CTCAE


name: Grade 3 Bronchospasm and Wheezing, CTCAE


name: Grade 4 Lymphatic Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Rectal Fissure, CTCAE

description: Asymptomatic


Stage II Cervical Cancer FIGO 2018

description: The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Low Grade Osteosarcoma

description: An osteosarcoma with low-grade morphological features. This category includes parosteal osteosarcoma and low-grade central osteosarcoma.


name: Grade 4 Neonatal Spontaneous Intestinal Perforation, AE

description: A spontaneous intestinal perforation (SIP) adverse event in a newborn characterized by life-threatening consequences (e.g. shock, organ failure); urgent intervention indicated.


Obstructed femoral hernia

description: The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis.


name: Thrombotic Thrombocytopenic Purpura, CTCAE

description: A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.


Restenosis

description: The reoccurrence of stenosis after it has been treated.


description: Tuberculosis disease that is caused by a pre-extensively drug-resistant strain of Mycobacterium tuberculosis.


name: Grade 1 Upper Gastrointestinal Hemorrhage NOS, CTCAE


Vascular Access Device Complications

description: Difficulties related to an apparatus used to gain access to arteries and veins.


Subpleural Nodule

description: A nodule that is directly underlying a pleural surface though there may be separation between the nodule margin and pleura.


Non-Neoplastic Pancreatic Disorder

description: A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


name: Adverse Event Associated with Blood and Bone Marrow


Elevated Blood Pressure Measurement

description: An abnormally high blood pressure reading.


name: Grade 2 Spleen Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Intraoperative Ocular Injury, CTCAE

description: A finding of damage to the eye during a surgical procedure.


Grade 2 Neck Edema, CTCAE

description: Moderate neck edema; slight obliteration of anatomic landmarks; limiting instrumental ADL


Sporadic Gastric Diffuse Adenocarcinoma

description: A sporadic adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations.


Cesarean Scar Pregnancy

description: An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.


name: Urinary Tract Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils NOS, CTCAE


Hypoparathyroidism, CTCAE

description: A disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands.


name: Leukoencephalopathy Radiographic Findings, CTCAE


Grade 3 Localized Edema, CTCAE

description: Severe localized edema and intervention indicated; limiting self care ADL


name: Grade 2 Jejunum Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 1 Colon Stricture or Stenosis, CTCAE


Kir6.2-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the KCNJ11 gene, encoding the inwardly rectifying Kir6.2 subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the KCNJ11 gene result in hyperinsulinism.


name: Grade 4 Prolapse of Intestinal Stoma, CTCAE

description: Life-threatening consequences; urgent operative intervention indicated


Congenital neuropathy

description: Neuropathy, the cause of which is present at birth.


Grade 5 Anal Necrosis, CTCAE

description: Death


name: Grade 5 Rectum Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


Recurrent Ureter Carcinoma

description: The reemergence of ureter carcinoma after a period of remission


Cystitis Cystica and Glandularis

description: A reactive inflammatory disorder affecting the bladder.  It is characterized by the development of small cysts in the bladder wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Vestibular Disorder, CTCAE

description: A disorder characterized by dizziness, imbalance, nausea, and vision problems.


name: Cranial Nerve Or Branch NOS Intra-Operative Injury, CTCAE


Grade 3 Hypopituitarism, CTCAE

description: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL


Grade 1 Extrapyramidal Disorder, CTCAE

description: Mild involuntary movements


Non-Neoplastic Gallbladder Disorder

description: A non-neoplastic disorder that affects the gallbladder. Representative examples include cholecystitis and adenomyomatosis.


name: Stage III Low Grade Adult Non-Hodgkin's Lymphoma


name: Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type

description: An X-linked recessive condition caused by mutation(s) in the UBE2A gene, encoding ubiquitin-conjugating enzyme E2 A. It is characterized by facial dysmorphisms and intellectual impairment.


name: Grade 2 Heart Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Liver Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

description: A malignant peripheral nerve sheath tumor characterized by the presence of mesenchymal differentiation.  Representative example is the malignant Triton tumor which contains a rhabdomyosarcomatous component.


Grade 4 Psychosis, CTCAE

description: Life-threatening consequences, threats of harm to self or others; hospitalization indicated


Laceration

description: A cut or tear in any tissue.


name: Grade 2 Thrombosis or Embolism Vascular Access Related, CTCAE


name: Grade 2 Gallbladder Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 4 Kidney Intra-Operative Injury, CTCAE


Grade 5 Thromboembolic Event, CTCAE

description: Death


Bisphosphonate-associated osteonecrosis

description: Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy.  It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery.  In a minority of cases, the necrosis appears spontaneously.  Signs and symptoms include pain, swelling and infection of the affected area.


Benign Extragonadal Germ Cell Tumor

description: A germ cell tumor that arises from an anatomic site other than the testis or ovary. There is no evidence of atypia or metastases.


name: Unspecified nonpsychotic mental disorder following organic brain damage

description: Any mental disorder that occurs secondary to organic brain damage, and that is not associated with psychosis.


Neutrophil Count Decreased, CTCAE

description: A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.


name: Grade 3 Middle Ear Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Refractory Endometrial Squamous Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


Gastrointestinal Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the gastrointestinal region.


Grade 1 Thromboembolic Event, CTCAE

description: Medical intervention not indicated (e.g., superficial thrombosis)


name: Kidney Mixed Epithelial and Stromal Tumor Family

description: A family of tumors ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors) and contain biphasic epithelial and stromal components with spindle stroma, glands, and cysts. Most of these tumors are benign. (WHO 2016).


Fecal Incontinence, CTCAE

description: A disorder characterized by inability to control the escape of stool from the rectum.


description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the skin.


Refractory Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that is resistant to treatment.


name: Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodular sclerosis classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


name: Grade 3 Artery Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Leukoencephalopathy, CTCAE

description: Asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly


Cervical Meningocele

description: A congenital abnormality in the cervical region of the spine in which the meninges protrude through a defect in the spinal column.


Primary Cold Agglutinin Disease

description: A clonal B-cell lymphoproliferative disease of the bone marrow that results in autoimmune hemolytic anemia. It is distinct from lymphoplasmacytic lymphoma and IgM monoclonal gammopathy of undetermined significance. It lacks MYD88 gene mutation and is associated with trisomies of chromosomes 3, 12, and 18, and mutations in KMT2D and CARD11 genes.


Dyspnea, CTCAE

description: A disorder characterized by an uncomfortable sensation of difficulty breathing.


name: Recurrent High Grade Endometrioid Adenocarcinoma

description: The reemergence of high-grade endometrioid adenocarcinoma after a period of remission.


name: Acute Myeloid Leukemia with t(11;17)(q23;q21); ZBTB16-RARA

description: Acute myeloid leukemia with the variant RARA t(11;17)(q23;q21) and the expression of ZBTB16-RARA fusion protein.  It lacks differentiation response to retinoids treatment.


name: Grade 5 Allergic Reaction and Hypersensitivity Including Drug Fever, CTCAE


Pressure Chest Pain

description: The sensation of chest pain described as an object creating physical force.


Advanced cancer

description: A malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Grade 3 Upper Aerodigestive Infection NOS with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 5 Glomerular Filtration Rate, CTCAE


name: Grade 4 Penis Intra-Operative Injury, CTCAE


name: Ileum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 1 Palmar-Plantar Erythrodysesthesia Syndrome, CTCAE

description: Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain


name: Grade 4 Hemolytic Uremic Syndrome, CTCAE

description: Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)


name: Grade 3 Dental-Tooth Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 4 Anal or Perianal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 3 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Dermal Spitz Nevus

description: A Spitz nevus characterized by the presence of an intradermal melanocytic component without junctional melanocytic activity.


name: Grade 5 Nose Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 3 Pancreas Infection, CTCAE

description: IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated


name: Grade 3 Peripheral Nerve Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Grade 5 Extrapyramidal Disorder, CTCAE

description: Death


Grade 3 Chills, CTCAE

description: Severe or prolonged, not responsive to narcotics


Borderline Paratesticular Serous Tumor

description: A rare, non-invasive, serous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical columnar epithelial cells with eosinophilic cytoplasm. Mitoses are rare. Metastases have not been reported.


Grade 3 Hypohidrosis, CTCAE

description: Increase in body temperature; limiting self care ADL


name: Adult Nodular Sclerosis Classical Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in adults.


Chronic Myelomonocytic Leukemia-0

description: A chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood.


name: Diffuse malignant lymphoma - large non-cleaved cell

description: Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells.  The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas).


Trichoblastic carcinoma

description: A rare biphasic malignant neoplasm with dual differentiation towards the specialized follicular stroma and germinative follicular cells, which can be strikingly atypical. (WHO 2018)


Grade 4 Hyponatremia, CTCAE

description: <120 mmol/L; life-threatening consequences


name: Acute Myeloid Leukemia with t(11;19)(q23.3;p13.1); KMT2A-ELL

description: An acute myeloid leukemia associated with t(11;19)(q23.3;p13.1) resulting in KMT2A-ELL gene fusion.


Shooting Pain

description: An intense sensation of discomfort or distress that radiates from one location to another sharply.


name: Stage IB Pancreatic Cancer AJCC v6 and v7

description: Stage IB includes: T2, N0, M0. T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A

description: An acute myeloid leukemia associated with t(10;11)(q21.3;q23.3) resulting in TET1-KMT2A gene fusion.


name: Grade 4 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 3 Cecum Infection with Unknown Absolute Neutrophil Count, CTCAE


Pre-Malignant Skin Epithelial Lesion

description: A term that refers to precancerous epithelial pathologic processes that affect the skin.


name: Reactive lymphoid hyperplasia of lacrimal gland

description: A polyclonal proliferation of lymphoid tissue in the lacrimal gland. It usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. It has a tendency to involve bilateral lacrimal glands. There is a higher incidence in females and in the setting of autoimmune disease. (WHO 2018)


Uterine Obstruction, CTCAE

description: A disorder characterized by blockage of the uterine outlet.


name: Grade 5 Peristomal Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Kidney Infection, CTCAE

description: A disorder characterized by an infectious process involving the kidney.


Sign or Symptom

description: Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

description: A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


Grade 4 Generalized Edema, CTCAE

description: Life-threatening consequences


name: Asymptomatic human immunodeficiency virus infection

description: An infection caused by human immunodeficiency virus (HIV) that is asymptomatic at the time of testing.


name: Grade 5 Vas Deferens Anastomotic Leak, CTCAE

description: Death


name: 21-hydroxylase deficiency - simple virilizing

description: A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


Pharyngolaryngeal Pain, CTCAE

description: A disorder characterized by a sensation of marked discomfort in the pharyngolaryngeal region.


name: PERSISTENT MULLERIAN DUCT SYNDROME, TYPE I

description: Persistent Mullerian duct syndrome due to deficiency of anti-Mullerian hormone.


Grade 1 Hair Texture Abnormal, CTCAE

description: Present


Recurrent Cervical Adenocarcinoma

description: The reemergence of cervical adenocarcinoma after a period of remission.


Grade 1 Ileal Fistula, CTCAE

description: Asymptomatic


Chronic diastolic heart failure

description: Chronic congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


Grade 4 Chylothorax, CTCAE

description: Life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated


name: Cranial Nerve IV Intra-Operative Injury, CTCAE


name: Non-Invasive Pancreatic Mucinous-Cystic Neoplasm

description: A cystic epithelial neoplasm that arises from the pancreas and is characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component.


Refractory Malignant Lymphoid Neoplasm

description: A malignant lymphoid neoplasm that does not respond to treatment.


name: Grade 3 Spermatic Cord Perforation, CTCAE


Hepatitis Viral, CTCAE

description: A disorder characterized by a viral pathologic process involving the liver parenchyma.


Splenic thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the splenic vein or splenic artery.


name: Grade 5 Mucosa Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Stage I Osteosarcoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Combined BAP1-inactivated melanocytoma

description: A BAP1-inactivated melanocytoma that is combined with a smaller area of melanocytic proliferation in the basal layer of the epidermis.


Acne aggravated

description: A flare of acne which may be precipitated by variety of factors, including hormonal activity, stress, oils and oily cosmetics, sweat, overwashing, and certain foods and drugs.


Grade 4 Pancreatic Fistula, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Malignant glioma of brain

description: A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma).


name: Injection Site Reaction or Extravasation Changes, CTCAE


name: Grade 2 Other Growth and Development, CTCAE


Grade 2 Otitis Externa, CTCAE

description: Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)


name: Grade 5 Pancreas Exocrine Enzyme Deficiency, CTCAE


Grade 5 Pharyngeal Hemorrhage, CTCAE

description: Death


name: Esophagus Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Grade 2 Artery Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Grade 4 Lens Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Adenocarcinoma in situ in adenomatous polyp

description: A non-invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


Pseudoepitheliomatous hyperplasia

description: A benign lesion characterized by epidermal and adnexal epithelial hyperplasia.  It is caused by chronic inflammation and infection.  It may be associated with cutaneous neoplasms as well.


name: Cervical Squamous Intraepithelial Neoplasia 1

description: Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper two-thirds of the squamous epithelium and mild nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal third of the epithelium.


Grade 5 Ileal Hemorrhage, CTCAE

description: Death


name: Grade 2 Jugular Vein Intra-Operative Injury, CTCAE


name: Grade 1 Paroxysmal Atrial Tachycardia, CTCAE

description: Asymptomatic, intervention not indicated


Cerebral Hemangioblastoma

description: A hemangioblastoma that arises from the cerebrum.


name: Hodgkin's disease lymphocyte predominance type stage IV

description: Stage IV adult Hodgkin disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


Recurrent Intracranial Neoplasm

description: The reemergence of an intracranial neoplasm after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

description: A non-neoplastic disorder that affects the eye.


Biliary Tract Infection, CTCAE

description: A disorder characterized by an infectious process involving the biliary tract.


Grade 5 Urostomy Stenosis, CTCAE

description: Death


description: Esophageal adenocarcinoma that has metastasized to a limited number of sites.


Grade 1 Ileal Hemorrhage, CTCAE

description: Mild symptoms; intervention not indicated


name: Grade 4 Spinal Cord Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Trachea Mucositis or Stomatitis by Clinical Examination Classification, CTCAE


name: New Onset Atrial Fibrillation Related to COVID-19

description: Newly occurring atrial fibrillation (AF) in a patient with probable or confirmed acute COVID-19. It is further categorized as first detected AF, paroxysmal AF (self-terminating within seven days of recognized onset), or persistent AF (not self-terminating within seven days).


Blood and lymphatic system disorders

description: A non-neoplastic or neoplastic disorder that affects the hematopoietic and lymphatic system.


Rectal Fissure, CTCAE

description: A disorder characterized by a tear in the lining of the rectum.


Metastatic Cervical Carcinoma

description: A carcinoma of the cervix that has spread to another anatomic site.


Grade 4 Pharyngitis, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Symptom

description: Subjective evidence of disease perceived by the patient.


name: MYOD1-Mutant Spindle Cell/Sclerosing Rhabdomyosarcoma

description: Spindle cell/sclerosing rhabdomyosarcoma characterized by the presence of MYOD1 p.Leu122Arg substitution mutation. This subtype includes most spindle cell/sclerosing rhabdomyosarcomas in adolescents and young adults, as well as some cases in older adults. It follows an aggressive clinical course.


name: Metastatic Bladder Lipid-Rich Urothelial Carcinoma

description: Bladder lipid-rich urothelial carcinoma that has spread to another anatomic site.


name: Hodgkin's disease nodular sclerosis stage II supradiaphragmatic


Refractory Adnexal Carcinoma

description: Adnexal carcinoma that is resistant to treatment.


name: Grade 4 Biliary Tree Common Bile Duct Intra-Operative Injury, CTCAE


name: 46,XX/46,XY Ovotesticular Differences of Sex Development

description: Ovotesticular differences of sex development in individuals with 46,XY/46,XX mosaic karyotype.


Elevated Test Result

description: A result of a test that is higher than a previous value or a normal range of values.


name: Grade 2 Intra-Abdominal Hemorrhage, CTCAE

description: Moderate symptoms; intervention indicated


name: Grade 1 Breast Nipple and Areolar Deformity, CTCAE


name: Grade 4 Appendix Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Purpura, CTCAE

description: Combined area of lesions covering <10% BSA


name: Grade 3 Prolapse of Gastrointestinal Stoma, CTCAE


Grade 2 Hypercalcemia, CTCAE

description: Corrected serum calcium of >11.5-12.5 mg/dL; >2.9-3.1 mmol/L; Ionized calcium >1.5-1.6 mmol/L; symptomatic


name: Grade 4 Soft Tissue NOS Intra-Operative Injury, CTCAE


name: Joint Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Acute Pericarditis Related to COVID-19

description: Acute pericarditis in a patient with probable or confirmed acute COVID-19.


Grade 1 Nail Loss, CTCAE

description: Asymptomatic separation of the nail bed from the nail plate or nail loss


name: Low Grade Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal glandular epithelium.


Oral Cavity Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site.


name: Grade 1 Heart Intra-Operative Injury, CTCAE


Grade 2 Pain, CTCAE

description: Moderate pain; limiting instrumental ADL


Cryptococcal gastroenteritis

description: Gastroenteritis resulting from an infection with cryptosporidium.


name: Grade 3 Neuroendocrine Gonadotropin Secretion Abnormality, CTCAE


Grade 3 Skin Induration, CTCAE

description: Severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL


name: Grade 4 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


Grade 1 Dysphasia, CTCAE

description: Awareness of receptive or expressive characteristics; not impairing ability to communicate


Unresectable Gastric Carcinoma

description: A gastric carcinoma that is not amenable to surgical resection.


Grade 4 Uterine Infection, CTCAE

description: Life-threatening consequences; urgent intervention indicated


Grade 2 Insomnia, CTCAE

description: Moderate difficulty falling asleep, staying asleep or waking up early


name: Grade 2 Blood Gonadotrophin Abnormal, CTCAE

description: Symptomatic; medical intervention indicated; limiting instrumental ADL


Soft Tissue Infection, CTCAE

description: A disorder characterized by an infectious process involving soft tissues.


name: Grade 5 Other Metabolic and Laboratory, CTCAE


Grade 1 Thrush, CTCAE

description: Asymptomatic; local symptomatic management


name: Grade 2 Scrotum Intra-Operative Injury, CTCAE


name: Grade 3 Blood Infection with Unknown Absolute Neutrophil Count, CTCAE


name: Recurrent Fallopian Tube Endometrioid Adenocarcinoma

description: The reemergence of fallopian tube endometrioid adenocarcinoma after a period of remission.


name: Grade 4 Fallopian Tube Infection with Unknown Absolute Neutrophil Count, CTCAE


Gnathoschisis

description: A congenital abnormality consisting of clefting in the jaw, which results from incomplete fusion of the embryonic mandibular prominence.


Intraoperative Breast Injury

description: Damage to the breast parenchyma during a surgical procedure.


Non-Neoplastic Bone Disorder

description: A non-neoplastic disorder that affects the bone or articular cartilage.


Adult Ganglioneuroma

description: A ganglioneuroma that occurs in adults.


name: Grade 4 Cervix Intra-Operative Injury, CTCAE


Grade 3 Skin Ulceration, CTCAE

description: Combined area of ulcers >2 cm; full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia


Blood Prolactin Abnormal, CTCAE

description: A finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen.


Preexisting Genetic Condition

description: A condition that existed previously and is genetic in nature.


Grade 3 Pharyngeal Hemorrhage, CTCAE

description: Transfusion indicated; invasive intervention indicated; hospitalization


Nonerosive Arthritis

description: An inflammation of one or more joints, without loss of articular cartilage or destruction of subchondral bone.


name: Grade 3 Rectum Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Complete Atrioventricular Septal Defect with Tetralogy of Fallot

description: A rare congenital heart anomaly in which there is coexistence of tetralogy of Fallot and complete atrioventricular septal defect. The latter is characterized by defects in the atrial and ventricular septa and a common atrioventricular valve.


Grade 5 Pharyngitis, CTCAE

description: Death


name: Gallbladder Adenocarcinoma, Biliary Type

description: A well or moderately differentiated adenocarcinoma that arises from the gallbladder.  It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands.  Intestinal differentiation may be present.


name: Grade 4 Oral Cavity or Gum Infection with Unknown Absolute Neutrophil Count, CTCAE


Grade 5 Acidosis, CTCAE

description: Death


Locally Advanced Unresectable Sarcoma

description: A sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Fat Atrophy, CTCAE

description: A disorder characterized by shrinking of adipose tissue.


Recurrent Low Grade Glioma

description: The reemergence of low grade glioma after a period of remission.


name: Grade 2 Muscle Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Non-Neoplastic Endocrine Pancreas Disorder

description: A non-neoplastic disorder that affects the endocrine pancreas.


Estrogen Receptor Status 1+

description: An immunohistochemical result of 1 for estrogen receptor expression that is considered weak for expression.


Hepatic Infection, CTCAE

description: A disorder characterized by an infectious process involving the liver.


name: Invasive Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma that exhibits squamous differentiation.


Grade 1 Sinus Tachycardia, CTCAE

description: Asymptomatic, intervention not indicated


Chest Pain in Intercostal Space

description: The location of the chest pain is in the area defined by a superior rib margin and an inferior rib margin.


Chronic Lymphoblastic Lymphoma

description: This is an invalid term; lymphoblastic lymphomas are not chronic processes, but counterparts of acute lymphoblastic leukemias.


Pneumonitis, CTCAE

description: A disorder characterized by inflammation focally or diffusely affecting the lung parenchyma.


name: Grade 3 Abdomen Soft Tissue Necrosis, CTCAE


Lip Infection

description: An acute or chronic infectious process affecting the lips.


name: Endometrioid Adenocarcinoma of the Urinary Tract

description: An exceptionally rare endometrioid adenocarcinoma that arises from the urinary tract. It occurs in middle-aged and elderly females. It is associated with genitourinary endometriosis and has been described in the bladder and ureter.


Grade 5 Skin Ulceration, CTCAE

description: Death


Brain Development Abnormality

description: A group of congenital or acquired disorders that affect the normal development of the brain.


Grade 2 Lipase Increased, CTCAE

description: >1.5-2.0 x ULN; >2.0-5.0 x ULN and asymptomatic


name: Invasive Micropapillary Urothelial Carcinoma

description: Invasive urothelial carcinoma exhibiting micropapillary growth pattern.


Allergic arthritis

description: Arthritis occurring after the ingestion of allergenic substance(s).


Congenital deformity of hip joint

description: Any anatomic abnormality of the hip that is present at the time of birth.


name: Grade 2 Bronchopulmonary Hemorrhage NOS, CTCAE


name: Severe Gastrointestinal Tract Acute Graft Versus Host Disease

description: Graft versus host disease occurring in the gastrointestinal tract and is characterized by complications that may be life-threatening.


name: Grade 1 Fallopian Tube Stricture or Stenosis, CTCAE


name: Pathologic Stage I Retinoblastoma AJCC v8

description: Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Grade 2 General Disorders and Administration Site Conditions - Other, Specify, CTCAE

description: Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL


name: Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


name: Grade 2 Vaginitis Not Due to Infection, CTCAE


Breast Atrophy, CTCAE

description: A disorder characterized by underdevelopment of the breast.


Refractory Urinary System Carcinoma

description: Urinary system carcinoma that does not respond to treatment.


name: Large Bowel Mucositis or Stomatitis by Functional or Symptomatic Classification, CTCAE


name: Recurrent Malignant Male Reproductive System Neoplasm

description: The reemergence of a malignant male reproductive system neoplasm after a period of remission.


name: Grade 3 Induration or Fibrosis of the Skin and Subcutaneous Tissue, CTCAE


Lipohypertrophy, CTCAE

description: A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.


name: Invasive Bladder Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits squamous differentiation.


name: Grade 2 Superficial Thrombophlebitis, CTCAE

description: Present


name: Grade 2 Pelvis Infection NOS Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils, CTCAE


name: Grade 5 Lip or Perioral Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


name: Grade 1 Pregnancy, Puerperium and Perinatal Conditions - Other, Specify, CTCAE

description: Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated


name: Mixed Phenotype Acute Leukemia, T/Megakaryocytic

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of T-cell and megakaryocytic lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Conjunctival Melanoma In Situ

description: A term that refers to conjunctival melanocytic intraepithelial lesions with severe atypia involving close to full thickness of the epithelium or lesions with histologic characteristics of melanoma that lack documented evidence of subepithelial invasion.


Enterovesical Fistula, CTCAE

description: A disorder characterized by an abnormal communication between the urinary bladder and the intestine.


Thyroid colloid nodule

description: A non-cancerous thyroid gland nodule that contains colloid material.


name: Grade 3 Ungual Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils, CTCAE


Agitation, CTCAE 5.0

description: A disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension.


Clinical Stage I Retinoblastoma AJCC v8

description: Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

description: A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.