name: NEK11_HUMAN Serine/threonine-protein kinase Nek11 (sprot)

description: A serine/threonine-protein kinase Nek11 that is encoded in the genome of human.


name: DUSTY_HUMAN Dual serine/threonine and tyrosine protein kinase (sprot)

description: A dual serine/threonine and tyrosine protein kinase that is encoded in the genome of human.


name: RPOB_MYCTU DNA-directed RNA polymerase subunit beta (sprot)


name: PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (sprot)

description: A tyrosine-protein phosphatase non-receptor type 7 that is encoded in the genome of human.


name: TAAR1_MACMU Trace amine-associated receptor 1 (sprot)

description: A trace amine-associated receptor 1 that is encoded in the genome of Macaca mulatta.


name: A6YCJ1_9METZ Carbonic anhydrase (trembl)


name: RBP_CHICK Riboflavin-binding protein (sprot)

description: A protein that is a translation product of the RTBDN gene in chicken.


name: SEPR_MOUSE Prolyl endopeptidase FAP (sprot)

description: A prolyl endopeptidase FAP that is encoded in the genome of mouse.


SMO_HUMAN Protein smoothened (sprot)

A protein smoothened that is encoded in the genome of human.


name: FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP5 that is encoded in the genome of human.


name: C3SLN2_ECOLX DNA gyrase subunit B (trembl)


name: Q9RMI3_STAAU Enoyl-[acyl-carrier-protein] reductase [NADPH] (trembl)


NRAM_I33A0 Neuraminidase (sprot)

A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Wilson-Smith/1933.


AMPN_MOUSE Aminopeptidase N (sprot)

An aminopeptidase N that is encoded in the genome of mouse.


name: I23O2_MOUSE Indoleamine 2,3-dioxygenase 2 (sprot)

description: An indoleamine 2,3-dioxygenase 2 that is encoded in the genome of mouse.


name: S47A1_HUMAN Multidrug and toxin extrusion protein 1 (sprot)

description: A multidrug and toxin extrusion protein 1 that is encoded in the genome of human.


name: S47A2_HUMAN Multidrug and toxin extrusion protein 2 (sprot)

description: A multidrug and toxin extrusion protein 2 that is encoded in the genome of human.


name: FNTB_HUMAN Protein farnesyltransferase subunit beta (sprot)

description: A protein farnesyltransferase subunit beta that is encoded in the genome of human.


name: VIPR1_HUMAN Vasoactive intestinal polypeptide receptor 1 (sprot)

description: A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human.


name: TTGR_PSEPK Probable HTH-type transcriptional regulator TtgR (sprot)


name: PPAP_HUMAN Prostatic acid phosphatase (sprot)

description: A prostatic acid phosphatase that is encoded in the genome of human.


name: HS90A_HUMAN Heat shock protein HSP 90-alpha (sprot)

description: A heat shock protein HSP 90-alpha that is encoded in the genome of human.


name: S23A2_HUMAN Solute carrier family 23 member 2 (sprot)

description: A solute carrier family 23 member 2 that is encoded in the genome of human.


name: S22A3_HUMAN Solute carrier family 22 member 3 (sprot)

description: A solute carrier family 22 member 3 that is encoded in the genome of human.


name: NADE_ECOLI NH(3)-dependent NAD(+) synthetase (sprot)

description: An NH(3)-dependent NAD(+) synthetase that is encoded in the genome of Escherichia coli K-12.


name: TRPM5_HUMAN Transient receptor potential cation channel subfamily M member 5 (sprot)

description: A transient receptor potential cation channel subfamily M member 5 that is encoded in the genome of human.


name: SCAF_HHV11 Capsid scaffolding protein (sprot)


name: DRTS_TRYBB Bifunctional dihydrofolate reductase-thymidylate synthase (sprot)


name: PTGDS_HUMAN Prostaglandin-H2 D-isomerase (sprot)

description: A prostaglandin-H2 D-isomerase that is encoded in the genome of human.


name: AGTR1_CAVPO Type-1 angiotensin II receptor (sprot)


name: TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (sprot)

description: A poly [ADP-ribose] polymerase tankyrase-1 that is encoded in the genome of human.


name: IF4E_HUMAN Eukaryotic translation initiation factor 4E (sprot)

description: A eukaryotic translation initiation factor 4E that is encoded in the genome of human.


name: PDE5A_CANLF cGMP-specific 3',5'-cyclic phosphodiesterase (sprot)


name: VGFR2_DANRE Vascular endothelial growth factor receptor 2 (sprot)

description: A vascular endothelial growth factor receptor 2 that is encoded in the genome of zebrafish.


name: S6A12_MOUSE Sodium- and chloride-dependent betaine transporter (sprot)

description: A sodium- and chloride-dependent betaine transporter that is encoded in the genome of mouse.


name: AMPX_VIBPR Bacterial leucyl aminopeptidase (sprot)


5NTD_RAT 5'-nucleotidase (sprot)

A 5'-nucleotidase that is encoded in the genome of rat.


name: Q965D7_PLAFA 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (trembl)


name: P85A_HUMAN Phosphatidylinositol 3-kinase regulatory subunit alpha (sprot)

description: A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human.


NOX4_HUMAN NADPH oxidase 4 (sprot)

An NADPH oxidase 4 that is encoded in the genome of human.


name: R1AB_SARS Replicase polyprotein 1ab (sprot)


name: PGH1_RABIT Prostaglandin G/H synthase 1 (sprot)

description: A prostaglandin G/H synthase 1 that is encoded in the genome of rabbit.


name: PGH2_RABIT Prostaglandin G/H synthase 2 (sprot)


name: PNMT_HUMAN Phenylethanolamine N-methyltransferase (sprot)

description: A phenylethanolamine N-methyltransferase that is encoded in the genome of human.


CRBN_HUMAN Protein cereblon (sprot)

A protein cereblon that is encoded in the genome of human.


name: OX2R_HUMAN Orexin receptor type 2 (sprot)

description: An orexin receptor type 2 that is encoded in the genome of human.


name: Q9YQ12_9HIV1 Protease (Fragment) (trembl)


name: RXRA_RAT Retinoic acid receptor RXR-alpha (sprot)

description: A retinoic acid receptor RXR-alpha that is encoded in the genome of rat.


name: Q9WKE8_9HIV1 Reverse transcriptase (Fragment) (trembl)


name: DYR_MYCTU Dihydrofolate reductase (sprot)


name: GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit rho-1 that is encoded in the genome of human.


name: Q9BEG3_BOVIN 5-lipoxygenase (Fragment) (trembl)


name: LOX5_MOUSE Polyunsaturated fatty acid 5-lipoxygenase (sprot)

description: A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of mouse.


PERL_BOVIN Lactoperoxidase (sprot)

A lactoperoxidase that is encoded in the genome of cow.


name: PDE4A_CAVPO 3',5'-cyclic-AMP phosphodiesterase 4A (Fragment) (sprot)


P2RX4_HUMAN P2X purinoceptor 4 (sprot)

A P2X purinoceptor 4 that is encoded in the genome of human.


name: ACM1_DROME Muscarinic acetylcholine receptor DM1 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of fruit fly.


name: S22A1_MOUSE Solute carrier family 22 member 1 (sprot)

description: A solute carrier family 22 member 1 that is encoded in the genome of mouse.


name: KDM1A_HUMAN Lysine-specific histone demethylase 1A (sprot)

description: A lysine-specific histone demethylase 1A that is encoded in the genome of human.


name: PFKA_TRYBB ATP-dependent 6-phosphofructokinase (sprot)


name: Q7YWJ9_MUSDO Carboxylic ester hydrolase (trembl)


name: DDL_HELPH D-alanine--D-alanine ligase (sprot)


name: ETV6_HUMAN Transcription factor ETV6 (sprot)

description: A transcription factor ETV6 that is encoded in the genome of human.


name: SYLC_YEAST Leucine--tRNA ligase, cytoplasmic (sprot)

description: A leucine--tRNA ligase, cytoplasmic that is encoded in the genome of yeast.


name: Q24982_GIAIN Pyruvate:ferredoxin oxidoreductase (trembl)


name: Q95US7_SCHMA High voltage-activated calcium channel beta subunit CavB1 (trembl)


name: Q962H3_SCHMA High voltage-activated calcium channel beta subunit CavB2 (trembl)


name: IOD1_HUMAN Type I iodothyronine deiodinase (sprot)

description: A type I iodothyronine deiodinase that is encoded in the genome of human.


name: Q8JXU8_9HEPC RNA-directed RNA polymerase (Fragment) (trembl)


name: Q25704_PLAFA 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase (trembl)


name: Q4WLT4_ASPFU 1,3-beta-glucan synthase (trembl)


name: CPSM_HUMAN Carbamoyl-phosphate synthase [ammonia], mitochondrial (sprot)

description: A carbamoyl-phosphate synthase [ammonia], mitochondrial that is encoded in the genome of human.


name: Q2VKV7_SARSC Sodium channel protein (Fragment) (trembl)


name: TPOR_HUMAN Thrombopoietin receptor (sprot)

description: A thrombopoietin receptor that is encoded in the genome of human.


name: KEAP1_HUMAN Kelch-like ECH-associated protein 1 (sprot)

description: A kelch-like ECH-associated protein 1 that is encoded in the genome of human.


name: S23A1_HUMAN Solute carrier family 23 member 1 (sprot)

description: A solute carrier family 23 member 1 that is encoded in the genome of human.


name: THAP1_HUMAN THAP domain-containing protein 1 (sprot)

description: A THAP domain-containing protein 1 that is encoded in the genome of human.


name: FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10 (sprot)

description: A peptidyl-prolyl cis-trans isomerase FKBP10 that is encoded in the genome of human.


name: DPYL2_HUMAN Dihydropyrimidinase-related protein 2 (sprot)

description: A dihydropyrimidinase-related protein 2 that is encoded in the genome of human.


name: DPOA2_HUMAN DNA polymerase alpha subunit B (sprot)

description: A DNA polymerase alpha subunit B that is encoded in the genome of human.


name: CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (sprot)

description: A 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial that is encoded in the genome of human.


name: VMAT1_HUMAN Chromaffin granule amine transporter (sprot)

description: A chromaffin granule amine transporter that is encoded in the genome of human.


name: DPOG1_HUMAN DNA polymerase subunit gamma-1 (sprot)

description: A DNA polymerase subunit gamma-1 that is encoded in the genome of human.


name: SO1A2_HUMAN Solute carrier organic anion transporter family member 1A2 (sprot)

description: A solute carrier organic anion transporter family member 1A2 that is encoded in the genome of human.


name: AHR_HUMAN Aryl hydrocarbon receptor (sprot)

description: An aryl hydrocarbon receptor that is encoded in the genome of human.


name: UD15_HUMAN UDP-glucuronosyltransferase 1A5 (sprot)

description: A UDP-glucuronosyltransferase 1A5 that is encoded in the genome of human.


LEPR_HUMAN Leptin receptor (sprot)

A leptin receptor that is encoded in the genome of human.


An adenosylhomocysteinase that is encoded in the genome of human.


TCO1_HUMAN Transcobalamin-1 (sprot)

A transcobalamin-1 that is encoded in the genome of human.


name: RET1_HUMAN Retinol-binding protein 1 (sprot)

description: A retinol-binding protein 1 that is encoded in the genome of human.


name: SODM_HUMAN Superoxide dismutase [Mn], mitochondrial (sprot)

description: A superoxide dismutase [Mn], mitochondrial that is encoded in the genome of human.


TLR4_HUMAN Toll-like receptor 4 (sprot)

A Toll-like receptor 4 that is encoded in the genome of human.


name: PSD1_HUMAN PH and SEC7 domain-containing protein 1 (sprot)

description: A PH and SEC7 domain-containing protein 1 that is encoded in the genome of human.


S100P_HUMAN Protein S100-P (sprot)

A protein S100-P that is encoded in the genome of human.


name: ATP4B_RABIT Potassium-transporting ATPase subunit beta (sprot)


name: ATP4A_RABIT Potassium-transporting ATPase alpha chain 1 (sprot)


eltanolone

mrdef: A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.

description: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.


name: PARE_STRPN DNA topoisomerase 4 subunit B (sprot)

description: A protein that is a translation product of the parE gene in Streptococcus pneumoniae TIGR4.


name: ACHG_HUMAN Acetylcholine receptor subunit gamma (sprot)

description: An acetylcholine receptor subunit gamma that is encoded in the genome of human.


name: ACHB_HUMAN Acetylcholine receptor subunit beta (sprot)

description: An acetylcholine receptor subunit beta that is encoded in the genome of human.


name: ACHD_HUMAN Acetylcholine receptor subunit delta (sprot)

description: An acetylcholine receptor subunit delta that is encoded in the genome of human.


GYRA_STRPN DNA gyrase subunit A (sprot)

A DNA gyrase subunit A that is encoded in the genome of Streptococcus pneumoniae TIGR4.


name: URE1_ECOLX Urease subunit alpha (Fragment) (sprot)


name: PARE_ECOLI DNA topoisomerase 4 subunit B (sprot)

description: A DNA topoisomerase 4 subunit B that is encoded in the genome of Escherichia coli K-12.


name: C4PKY4_ECHGR Beta-tubulin isoform 1 (Fragment) (trembl)


name: C4PKZ2_ECHGR Tubulin beta chain (Fragment) (trembl)


name: C4PKZ6_ECHGR Beta-tubulin isoform 3 (Fragment) (trembl)


name: H9U2V9_TETUR GABA-gated chloride channel 1 (trembl)


name: H9U2W0_TETUR GABA-gated chloride channel 2 (Fragment) (trembl)


name: H9U2W1_TETUR GABA-gated chloride channel 3 (Fragment) (trembl)


name: E0V9W2_PEDHC Gaba-gated chloride channel, putative (trembl)


name: E0VY07_PEDHC Gaba-gated chloride channel, putative (trembl)


name: E0W492_PEDHC Gaba-gated chloride channel, putative (trembl)


name: GBRP_RAT Gamma-aminobutyric acid receptor subunit pi (sprot)

description: A gamma-aminobutyric acid receptor subunit pi that is encoded in the genome of rat.


medazepam

mrdef: A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM.


name: GBRB1_RAT Gamma-aminobutyric acid receptor subunit beta-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit beta-1 that is encoded in the genome of rat.


name: GBRD_RAT Gamma-aminobutyric acid receptor subunit delta (sprot)

description: A gamma-aminobutyric acid receptor subunit delta that is encoded in the genome of rat.


name: GBRA3_RAT Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of rat.


name: GBRA4_RAT Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of rat.


name: GBRG3_RAT Gamma-aminobutyric acid receptor subunit gamma-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit gamma-3 that is encoded in the genome of rat.


name: GBRE_RAT Gamma-aminobutyric acid receptor subunit epsilon (sprot)

description: A gamma-aminobutyric acid receptor subunit epsilon that is encoded in the genome of rat.


name: SCNNB_HUMAN Amiloride-sensitive sodium channel subunit beta (sprot)

description: An amiloride-sensitive sodium channel subunit beta that is encoded in the genome of human.


name: SCNNG_HUMAN Amiloride-sensitive sodium channel subunit gamma (sprot)

description: An amiloride-sensitive sodium channel subunit gamma that is encoded in the genome of human.


name: ACHB3_RAT Neuronal acetylcholine receptor subunit beta-3 (sprot)

description: A neuronal acetylcholine receptor subunit beta-3 that is encoded in the genome of rat.


name: ACHA5_RAT Neuronal acetylcholine receptor subunit alpha-5 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-5 that is encoded in the genome of rat.


name: ACHA_RAT Acetylcholine receptor subunit alpha (sprot)

description: An acetylcholine receptor subunit alpha that is encoded in the genome of rat.


name: ACHB_RAT Acetylcholine receptor subunit beta (sprot)

description: An acetylcholine receptor subunit beta that is encoded in the genome of rat.


name: ACHA6_RAT Neuronal acetylcholine receptor subunit alpha-6 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of rat.


name: ACH10_RAT Neuronal acetylcholine receptor subunit alpha-10 (sprot)

description: A neuronal acetylcholine receptor subunit alpha-10 that is encoded in the genome of rat.


name: GABR2_RAT Gamma-aminobutyric acid type B receptor subunit 2 (sprot)

description: A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of rat.


name: CCNB1_HUMAN G2/mitotic-specific cyclin-B1 (sprot)

description: A G2/mitotic-specific cyclin-B1 that is encoded in the genome of human.


name: CD5R1_HUMAN Cyclin-dependent kinase 5 activator 1 (sprot)

description: A cyclin-dependent kinase 5 activator 1 that is encoded in the genome of human.


name: CCNB2_HUMAN G2/mitotic-specific cyclin-B2 (sprot)

description: A G2/mitotic-specific cyclin-B2 that is encoded in the genome of human.


name: CCNB3_HUMAN G2/mitotic-specific cyclin-B3 (sprot)

description: A G2/mitotic-specific cyclin-B3 that is encoded in the genome of human.


name: ATP4B_PIG Potassium-transporting ATPase subunit beta (sprot)

description: A potassium-transporting ATPase subunit beta that is encoded in the genome of pig.


name: ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (sprot)

description: A potassium-transporting ATPase alpha chain 1 that is encoded in the genome of pig.


name: GBRA1_BOVIN Gamma-aminobutyric acid receptor subunit alpha-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of cow.


name: GBRB1_BOVIN Gamma-aminobutyric acid receptor subunit beta-1 (sprot)

description: A gamma-aminobutyric acid receptor subunit beta-1 that is encoded in the genome of cow.


name: GBRA2_BOVIN Gamma-aminobutyric acid receptor subunit alpha-2 (sprot)

description: A protein that is a translation product of any of the 2 copies of the GABRA2 gene in cow.


name: GBRA3_BOVIN Gamma-aminobutyric acid receptor subunit alpha-3 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of cow.


name: GBRA4_BOVIN Gamma-aminobutyric acid receptor subunit alpha-4 (sprot)

description: A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of cow.


name: GBRG2_BOVIN Gamma-aminobutyric acid receptor subunit gamma-2 (sprot)


name: TBA1B_HUMAN Tubulin alpha-1B chain (sprot)

description: A tubulin alpha-1B chain that is encoded in the genome of human.


name: TBA4A_HUMAN Tubulin alpha-4A chain (sprot)

description: A tubulin alpha-4A chain that is encoded in the genome of human.


name: TBA3E_HUMAN Tubulin alpha-3E chain (sprot)

description: A tubulin alpha-3E chain that is encoded in the genome of human.


name: TBA1A_HUMAN Tubulin alpha-1A chain (sprot)

description: A tubulin alpha-1A chain that is encoded in the genome of human.


name: TBA1C_HUMAN Tubulin alpha-1C chain (sprot)

description: A tubulin alpha-1C chain that is encoded in the genome of human.


name: KCNJ3_HUMAN G protein-activated inward rectifier potassium channel 1 (sprot)

description: A G protein-activated inward rectifier potassium channel 1 that is encoded in the genome of human.


name: HBB_HUMAN Hemoglobin subunit beta (sprot)

description: A hemoglobin subunit beta that is encoded in the genome of human.


name: 5HT3E_HUMAN 5-hydroxytryptamine receptor 3E (sprot)

description: A 5-hydroxytryptamine receptor 3E that is encoded in the genome of human.


name: 5HT3D_HUMAN 5-hydroxytryptamine receptor 3D (sprot)

description: A 5-hydroxytryptamine receptor 3D that is encoded in the genome of human.


name: 5HT3C_HUMAN 5-hydroxytryptamine receptor 3C (sprot)

description: A 5-hydroxytryptamine receptor 3C that is encoded in the genome of human.


name: FNTA_HUMAN Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (sprot)

description: A protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha that is encoded in the genome of human.


name: NCOR2_HUMAN Nuclear receptor corepressor 2 (sprot)

description: A nuclear receptor corepressor 2 that is encoded in the genome of human.


name: NCOR1_HUMAN Nuclear receptor corepressor 1 (sprot)

description: A nuclear receptor corepressor 1 that is encoded in the genome of human.


NPM_HUMAN Nucleophosmin (sprot)

A nucleophosmin that is encoded in the genome of human.


desomorphine

mrdef: an informal term for a cheap injectable illicit drug domestically prepared from codeine-containing medication in Russia


name: DRD5_RAT D(1B) dopamine receptor (sprot)

description: A D(1B) dopamine receptor that is encoded in the genome of rat.


name: D4A3N4_RAT Adenylate cyclase type 1 (trembl)


name: ADCY3_RAT Adenylate cyclase type 3 (sprot)

description: An adenylate cyclase type 3 that is encoded in the genome of rat.


name: ADCY2_RAT Adenylate cyclase type 2 (sprot)

description: An adenylate cyclase type 2 that is encoded in the genome of rat.


name: ADCY4_RAT Adenylate cyclase type 4 (sprot)

description: An adenylate cyclase type 4 that is encoded in the genome of rat.


name: ADCY8_RAT Adenylate cyclase type 8 (sprot)

description: An adenylate cyclase type 8 that is encoded in the genome of rat.


name: ADCY6_RAT Adenylate cyclase type 6 (sprot)

description: An adenylate cyclase type 6 that is encoded in the genome of rat.


name: Q8CFM9_RAT adenylate cyclase (Fragment) (trembl)


name: 5HT2A_MOUSE 5-hydroxytryptamine receptor 2A (sprot)

description: A 5-hydroxytryptamine receptor 2A that is encoded in the genome of mouse.


name: 5HT2B_MOUSE 5-hydroxytryptamine receptor 2B (sprot)

description: A 5-hydroxytryptamine receptor 2B that is encoded in the genome of mouse.


TRY2_HUMAN Trypsin-2 (sprot)

A trypsin-2 that is encoded in the genome of human.


TRY3_HUMAN Trypsin-3 (sprot)

A trypsin-3 that is encoded in the genome of human.


name: ACM4_MOUSE Muscarinic acetylcholine receptor M4 (sprot)

description: A muscarinic acetylcholine receptor M4 that is encoded in the genome of mouse.


name: ACM5_MOUSE Muscarinic acetylcholine receptor M5 (sprot)

description: A muscarinic acetylcholine receptor M5 that is encoded in the genome of mouse.


name: ACM3_MOUSE Muscarinic acetylcholine receptor M3 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of mouse.


name: SCN1A_RAT Sodium channel protein type 1 subunit alpha (sprot)

description: A sodium channel protein type 1 subunit alpha that is encoded in the genome of rat.


name: CNRG_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

description: A retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma that is encoded in the genome of human.


name: PDE6B_HUMAN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (sprot)

description: A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta that is encoded in the genome of human.


name: CNCG_HUMAN Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

description: A retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma that is encoded in the genome of human.


name: KPCZ_HUMAN Protein kinase C zeta type (sprot)

description: A protein kinase C zeta type that is encoded in the genome of human.


name: ADH1E_HORSE Alcohol dehydrogenase E chain (sprot)

description: A protein that is a translation product of the LOC100034242 gene in horse.


name: ADH1S_HORSE Alcohol dehydrogenase S chain (sprot)

description: A protein that is a translation product of the LOC100034175 gene in horse.


name: ADA2B_MOUSE Alpha-2B adrenergic receptor (sprot)

description: An alpha-2B adrenergic receptor that is encoded in the genome of mouse.


name: CNRG_BOVIN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

description: A protein that is a translation product of the PDE6G gene in cow.


name: CNCG_BOVIN Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (sprot)

description: A retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma that is encoded in the genome of cow.


name: PDE6B_BOVIN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (sprot)

description: A rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta that is encoded in the genome of cow.


name: PDE6D_BOVIN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (sprot)

description: A retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta that is encoded in the genome of cow.


name: PDE1B_RAT Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B that is encoded in the genome of rat.


name: PDE1C_RAT Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (sprot)

description: A dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C that is encoded in the genome of rat.


name: KPCA_RAT Protein kinase C alpha type (sprot)

description: A protein kinase C alpha type that is encoded in the genome of rat.


name: KPCD_RAT Protein kinase C delta type (sprot)

description: A protein that is a translation product of the Prkcd gene in rat.


name: KPCE_RAT Protein kinase C epsilon type (sprot)

description: A protein kinase C epsilon that is encoded in the genome of rat.


name: KPCZ_RAT Protein kinase C zeta type (sprot)

description: A protein kinase C zeta type that is encoded in the genome of rat.


name: KPCG_RAT Protein kinase C gamma type (sprot)

description: A protein kinase C gamma type that is encoded in the genome of rat.


name: KPCB_RAT Protein kinase C beta type (sprot)

description: A protein kinase C beta type that is encoded in the genome of rat.


name: KPCL_RAT Protein kinase C eta type (sprot)

description: A protein kinase C eta type that is encoded in the genome of rat.


name: KPCT_RAT Protein kinase C theta type (sprot)

description: A protein kinase C theta type that is encoded in the genome of rat.


CNR2_RAT Cannabinoid receptor 2 (sprot)

A cannabinoid receptor 2 that is encoded in the genome of rat.


name: ATPL_MYCTU ATP synthase subunit c (sprot)

description: A protein that is a translation product of the atpE gene in Mycobacterium tuberculosis H37Rv.


name: ATPB_MYCTU ATP synthase subunit beta (sprot)

description: An ATP synthase subunit beta, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: ATPA_MYCTU ATP synthase subunit alpha (sprot)

description: An ATP synthase subunit alpha, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: ATPG_MYCTU ATP synthase gamma chain (sprot)

description: An ATP synthase subunit gamma, mitochondrial that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: ATPE_MYCTU ATP synthase epsilon chain (sprot)

description: A protein that is a translation product of the atpC gene in Mycobacterium tuberculosis H37Rv.


name: ATPFD_MYCTU ATP synthase subunit b-delta (sprot)

description: A protein that is a translation product of the atpFH gene in Mycobacterium tuberculosis H37Rv.


name: ATPF_MYCTU ATP synthase subunit b (sprot)

description: An ATP synthase subunit b that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


name: ATP6_MYCTU ATP synthase subunit a (sprot)

description: An ATP synthase subunit a that is encoded in the genome of Mycobacterium tuberculosis H37Rv.


MYG_HUMAN Myoglobin (sprot)

A myoglobin that is encoded in the genome of human.


name: CASR_BOVIN Extracellular calcium-sensing receptor (sprot)

description: An extracellular calcium-sensing receptor that is encoded in the genome of cow.


name: CSF2R_HUMAN Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (sprot)

description: A granulocyte-macrophage colony-stimulating factor receptor subunit alpha that is encoded in the genome of human.


name: IL6RA_HUMAN Interleukin-6 receptor subunit alpha (sprot)

description: An interleukin-6 receptor subunit alpha that is encoded in the genome of human.


name: IL6RB_HUMAN Interleukin-6 receptor subunit beta (sprot)

description: An interleukin-6 receptor subunit beta that is encoded in the genome of human.


name: I11RA_HUMAN Interleukin-11 receptor subunit alpha (sprot)

description: An interleukin-11 receptor subunit alpha that is encoded in the genome of human.


name: INAR2_HUMAN Interferon alpha/beta receptor 2 (sprot)

description: An interferon alpha/beta receptor 2 that is encoded in the genome of human.


name: Grade 3 Intestinal Stoma Site Bleeding, CTCAE

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Transfusion indicated; invasive intervention indicated


Intestinal Stoma Site Bleeding, CTCAE

description: A disorder characterized by bleeding from the intestinal stoma.


name: Grade 1 Intestinal Stoma Site Bleeding, CTCAE

description: Minimal bleeding identified on clinical exam; intervention not indicated


name: Grade 5 Intestinal Stoma Site Bleeding, CTCAE

description: Death


name: Grade 2 Intestinal Stoma Site Bleeding, CTCAE

description: Moderate bleeding; medical intervention indicated


name: Grade 4 Intestinal Stoma Site Bleeding, CTCAE

description: Life-threatening consequences; urgent intervention indicated


name: DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)

description: A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318.


Obstructive Ureterocele

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A ureterocele with a small, obstructive orifice.


ureterocele

description: A cystic and dysplastic dilation of the distal ureter within the bladder that may extend into the bladder neck and urethra.


Orthotopic ureterocele

description: A ureterocele that is located entirely within the bladder, and which may be associated with a single system, with the upper pole ureter of a completely duplicated system, or rarely associated with a lower pole ureter. (Adapted from Glassberg KI, Braren V, Duckett JW, Jacobs EC, King LR, Lebowitz RL et al. Suggested terminology for duplex systems, ectopic ureters and ureteroceles. J Urol 1984; 132(6):1153-1154.)


Sphincteric Ureterocele

description: A ureterocele in which the orifice is distal to the external urinary sphincter.


Cecoureterocele

description: A ureterocele in which the orifice is located in the bladder, with the ureterocele pouch extending submucosally into the urethra.


Ectopic ureterocele

description: A ureterocele in which some portion of the ureterocele is situated permanently at the bladder neck or in the urethra. The orifice may be situated in the bladder, at the bladder neck, or in the urethra. (Adapted from Glassberg KI, Braren V, Duckett JW, Jacobs EC, King LR, Lebowitz RL et al. Suggested terminology for duplex systems, ectopic ureters and ureteroceles. J Urol 1984; 132(6):1153-1154.)


name: eukaryotic translation initiation factor 4E phosphorylated 1 (human)

description: A eukaryotic translation initiation factor 4E (human) that has been phosphorylated on the residue at the position equivalent to Ser-53 of the amino acid sequence represented by UniProtKB:P06730-1. Example: UniProtKB:P06730-1, Ser-53, MOD:00046.


taurodontism

description: Taurodontism is a dental anomaly characterized by an elongated pulp chamber, displaced toward the apical floor of the tooth with no constriction at the level of the cemento-enamel junction, and short roots. It most frequently affects permanent molar teeth. Taurodontism increases the risk of pulp exposure. It can be isolated or associated with certain syndromes such as Down syndrome, amelogenesis imperfecta, and Klinefelter syndrome.


name: myasthenic syndrome, congenital, 23, presynaptic


name: nephrolithiasis susceptibility caused by SLC26A1


name: serine/threonine-protein kinase VRK2 isoform h4 (human)

description: A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-4.


Postsurgical Stage II Hepatoblastoma

description: No metastases, tumor grossly resected with microscopic residual disease (i.e., positive margins); or tumor rupture, or tumor spill at the time of surgery. (from PDQ 2004)


name: potassium voltage-gated channel subfamily H member 5 isoform 3 (human)

description: A voltage-gated potassium channel KCNH5 isoform 3 that is encoded in the genome of human.


primary ciliary dyskinesia 4

description: A primary ciliary dyskinesia that is characterized by partial absence of the inner dynein arms with variable occurrence of situs inversus and has material basis in variation in the chromosome region 15q13.1-q15.1.


infantile diarrhea

description: Diarrhea occurring in infants from newborn to 24-months old.


Ulnar deviation of the 4th finger

description: Displacement of the 4th finger towards the ulnar side (i.e., towards the 5th finger).


Radial deviation of the 4th finger

description: Displacement of the 4th finger towards the radial side (i.e., towards the thumb).


Radial deviation of the 2nd finger

description: Displacement of the 2nd finger towards the radial side.


Ulnar deviation of thumb

description: Bending or curvature of a thumb towards the ulnar side (towards the ring finger).


Deviation of the 2nd finger

description: Displacement of the 2nd finger from its normal position.


Distally placed thumb

description: Insertion of thumb at a more distal location than normal.


Ulnar deviation of the 5th finger

description: Displacement of the 5th finger towards the ulnar side.


Radial deviation of the 3rd finger

description: Displacement of the 3rd finger towards the radial side (i.e., towards the thumb).


Ulnar deviation of the 2nd finger

description: Displacement of the 2nd (index) finger towards the ulnar side.


Hitchhiker thumb

description: With the hand relaxed and the thumb in the plane of the palm, the axis of the thumb forms an angle of at least 90 degrees with the long axis of the hand.


Ulnar deviation of finger

description: Bending or curvature of a finger toward the ulnar side (i.e., away from the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.


Clinodactyly of the 5th finger

description: Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger).


Deviation of the 5th finger

description: Displacement of the 5th finger from its normal position.


Overlapping fingers

description: A finger resting on the dorsal surface of an adjacent digit when the hand is at rest.


name: Fifth finger distal phalanx clinodactyly

description: Bending or curvature of the distal phalanx of little finger in the radial direction (i.e., towards the 4th finger).


Proximal placement of thumb

description: Proximal mislocalization of the thumb.


Ulnar deviation of the 3rd finger

description: Displacement of the 3rd finger towards the ulnar side (i.e., towards the ring finger).


Radial deviation of finger

description: Bending or curvature of a finger toward the radial side (i.e., towards the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.


Deviation of the thumb

description: Displacement of the thumb from its normal position.


Deviation of the 4th finger

description: Displacement of the 4th finger from its normal position.


Deviation of the 3rd finger

description: Displacement of the 3rd finger from its normal position.


name: Premature birth following premature rupture of fetal membranes


Preterm premature rupture of membranes

description: PPROM (preterm premature rupture of membranes) occurs at less than 37 weeks of gestation. PPROM can happen spontaneously, during preterm labor, or following a procedure such as amniocentesis.


name: Elevated circulating 4-methyl-2-oxopentanoic acid concentration

description: The concentration of 4-methyl-2-oxopentanoic acid in the blood circulation is above the upper limit of normal.


atrioventricular septal defect 4

description: Any atrioventricular septal defect in which the cause of the disease is a mutation in the GATA4 gene.


name: structural congenital heart disease, multiple types - GATA4

description: Any congenital heart disease in which the cause of the disease is a mutation in the GATA4 gene.


ventricular septal defect 1

description: Any ventricular septal defect in which the cause of the disease is a mutation in the GATA4 gene.


atrial septal defect 2

description: Any atrial heart septal defect in which the cause of the disease is a mutation in the GATA4 gene.


name: T-cell surface glycoprotein CD4 N-glycosylated 23 (human)

description: A T-cell surface glycoprotein CD4 (human) that has been N-glycosylated at the residue equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P01730-1, in which the glycan structure is represented by GlyTouCan:G65890UA. Example: UniProtKB:P01730-1, Asn-296, MOD:00160~GNO:G65890UA.


Localized Parathyroid Gland Carcinoma

description: A parathyroid gland carcinoma that has not spread to other anatomic sites.


head and neck carcinoma

description: A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.


name: Nasopharyngeal Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of nasopharyngeal carcinoma according to the American Joint Committee on Cancer, 7th edition.


name: Refractory Thyroid Gland Oncocytic Carcinoma

description: Thyroid gland oncocytic carcinoma that is resistant to treatment.


name: Stage II Differentiated Thyroid Gland Carcinoma AJCC v7

description: Stage II includes: Under 45 years: Any T, Any N, M1.  45 years and older: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M1: Distant metastasis.  M0: No evidence of distant metastasis.  (from AJCC 7th Ed.)


name: Oropharyngeal (p16-Negative) Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of p16-negative oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Thyroid Gland Sclerosing Mucoepidermoid Carcinoma with Eosinophilia

description: A rare type of mucoepidermoid carcinoma of the thyroid gland, usually associated with chronic lymphocytic thyroiditis.  It exhibits a unique morphologic appearance consisting of a squamoid, nested growth pattern, dense fibrosis, and mucinous differentiation.  The histogenesis of this unusual carcinoma has been debated, and it is unclear if it arises from remnants of the ultimobranchial body or from the follicular epithelial cells.


name: Stage I Thyroid Gland Follicular Carcinoma AJCC v8

description: Stage I includes: Under 55 years: Any T, Any N, M0. 55 years and older: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Unresectable Laryngeal Squamous Cell Carcinoma

description: Laryngeal squamous cell carcinoma that is not amenable to surgical resection.


name: Metastatic Nasopharyngeal Nonkeratinizing Carcinoma

description: Nasopharyngeal non-keratinizing carcinoma that has spread from its original site of growth to another anatomic site.


Stage IVC Laryngeal Cancer AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Hypopharyngeal Spindle Cell Squamous Carcinoma

description: A squamous cell carcinoma that arises from the hypopharynx. It is characterized by the presence of a malignant spindle cell cellular component. In some cases, there is a biphasic morphology due to the presence of a well-differentiated squamous cell carcinoma component. The latter is either in situ or invasive squamous cell carcinoma.


name: Metastatic Thyroid Gland Anaplastic Carcinoma

description: Thyroid gland anaplastic carcinoma that has spread from the original site of growth to another anatomic site.


name: Hypopharyngeal squamous cell carcinoma stage III

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor measuring more than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Oropharyngeal Human Papillomavirus-Related Non-Keratinizing Squamous Cell Carcinoma

description: An oropharyngeal human papillomavirus-related squamous cell carcinoma characterized by the absence of keratinization and intercellular bridges.


name: Stage I Hypopharyngeal Carcinoma AJCC v6

description: Stage I includes: T1, N0, M0.  T1: Tumor limited to one subsite of the hypopharynx and 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


name: Spindle Cell Variant Thyroid Gland Papillary Carcinoma

description: Papillary carcinoma of the thyroid gland with focal areas of spindle cell metaplasia.


Locally Advanced Laryngeal Carcinoma

description: Laryngeal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Carcinoma of pyriform fossa

description: A carcinoma that arises from the pyriform sinus.  Patients usually present with advanced stage disease and the prognosis is poor.


name: Refractory Differentiated Thyroid Gland Carcinoma

description: Differentiated thyroid gland carcinoma that is resistant to treatment.


Stage I Laryngeal Cancer AJCC v6 and v7

description: Stage I includes: T1, N0, M0.  T1: (Supraglottis) Tumor limited to one subsite of supraglottis with normal vocal cord mobility. (Glottis) Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility.  (Subglottis) Tumor limited to the subglottis.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Laryngeal Cancer by AJCC v8 Stage

description: A term that refers to the staging of laryngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage I includes: (T0, N0, M0); (T0, N1, M0); (T1, N0, M0); (T1, N1, M0); (T2, N0, M0); (T2, N1, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Tumor with metastasis in four or fewer lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8

description: Stage IVB includes: T4b, Any N, M0. T4b: Very advanced disease; tumor of any size with extension towards the spine or into nearby large blood vessels, invading the prevertebral fascia, or encasing the carotid artery or mediastinal vessels. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IVC Laryngeal Verrucous Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 7th ed.)


name: Thyroid Gland Papillary Carcinoma with Fibromatosis/Fasciitis-Like/Desmoid-Type Stroma

description: A rare morphologic variant of papillary thyroid gland carcinoma characterized by the presence of abundant and cellular stroma resembling nodular fasciitis, fibromatosis, or other proliferative myofibroblastic processes. (WHO)


name: Stage I Thyroid Gland Follicular Carcinoma Under 55 Years AJCC v8

description: Stage I includes: Any T, Any N, M0. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage II Laryngeal Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Supraglottis: Tumor invades the mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of the tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx. Glottis: Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility. Subglottis: Tumor extends to vocal cord(s) with normal or impaired mobility. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Laryngeal verrucous carcinoma stage IV

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Supraglottis: Moderately advanced local disease.  Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus).  Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  Subglottis: Moderately advanced local disease.  Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  T4b: Supraglottis, Glottis, and Subglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


name: Stage III Nasopharyngeal Carcinoma AJCC v7

description: Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor.  T3: Nasopharyngeal cancer with tumor involving bony structures of skull base and/or paranasal sinuses.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v8

description: Stage IVA includes: 55 years and older: T4b, Any N, M0. T4b: Gross extrathyroidal extension invading prevertebral fascia or encasing the carotid artery or mediastinal vessels from a tumor of any size. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: distant metastasis. (AJCC 8th ed.)


name: Metastatic Thyroid Gland Follicular Carcinoma

description: A follicular carcinoma that arises from the thyroid gland and has metastasized to another anatomic site.


hypopharynx squamous cell carcinoma

description: A squamous cell carcinoma that involves the hypopharynx.


name: Stage IVA Nasopharyngeal Carcinoma AJCC v8

description: Stage IVA includes: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); (Any T, N3, M0); T4: Tumor with intracranial extension, involvement of cranial nerves, hypopharynx, orbit, parotid gland, and/or extensive soft tissue infiltration beyond the lateral surface of the lateral pterygoid muscle.  N0: No regional lymph node metastasis. N1: Tumor with unilateral metastasis in cervical lymph node(s), and/or unilateral or bilateral metastasis in retropharyngeal lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. N2: Tumor with bilateral metastasis in cervical lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. N3: Tumor with unilateral or bilateral metastasis in cervical lymph node(s), larger than 6 cm in greatest dimension, and/or extension below the caudal border of cricoid cartilage. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVA Thyroid Gland Papillary Carcinoma AJCC v8


name: Hypopharyngeal Basaloid Squamous Cell Carcinoma

description: A high-grade, aggressive variant of squamous cell carcinoma that arises from the hypopharynx. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.


name: Stage IV Hypopharyngeal Carcinoma AJCC v6

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N, M1).  T4a: Tumor invades thyroid/cricoid cartilage, hyoid bone, thyroid gland, esophagus, or central compartment soft tissue.  T4b: Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures.  N2: Metastasis in a single ipsilateral lymph node, more than 3cm but not more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in greatest dimension.  N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  N3: Metastasis in a lymph node more than 6 cm in greatest dimension.  M1: Distant metastasis. (AJCC 6th ed.)


name: Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Unresectable Nasopharyngeal Squamous Cell Carcinoma

description: Nasopharyngeal squamous cell carcinoma that is not amenable to surgical resection.


name: Stage IV Oropharyngeal Undifferentiated Carcinoma AJCC v7

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N, M1). T4a: Tumor with moderately advanced local disease.  Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible.  Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis.  T4b: Tumor with very advanced local disease.  Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Tumor with metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


Metastatic Hypopharyngeal Carcinoma

description: A carcinoma that arises from the hypopharynx and has metastasized to another anatomic site.


name: Stage II Thyroid Gland Follicular Carcinoma AJCC v8

description: Stage II includes: Under 55 years: Any T, Any N, M1; 55 years and older: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage IVB Oropharyngeal Undifferentiated Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0). T4b: Tumor with very advanced local disease.  Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N3: Tumor with metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Nasopharyngeal Small Cell Neuroendocrine Carcinoma

description: An extremely rare small cell neuroendocrine carcinoma that arises from the nasopharynx.


pharynx carcinoma in situ

description: Stage 0 carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


name: Stage IVC Hypopharyngeal Squamous Cell Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Unresectable Oropharyngeal Squamous Cell Carcinoma

description: Oropharyngeal squamous cell carcinoma that is not amenable to surgical resection.


name: Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v7

description: Stage IVB includes: T4b, Any N, M0. T4b: Very advanced disease.  Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels.  M0: No distant metastasis. (AJCC 7th ed.)


Recurrent Thyroid Carcinoma

description: The reemergence of thyroid gland carcinoma after a period of remission.


carcinoma in situ of nasopharynx

description: A in situ carcinoma that involves the nasopharynx.


name: Nasopharyngeal lymphoepithelioma stage II

description: Stage II includes: (T1, N1, M0); (T2, N0, M0); (T2, N1, M0).  T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: papillary squamous cell carcinoma of larynx

description: A variant of squamous cell carcinoma that arises from the larynx. It is characterized by exophytic and papillary growth usually in the supraglottic area. The papillae are covered by a malignant stratified squamous epithelium.


name: Locally Recurrent Laryngeal Squamous Cell Carcinoma

description: The reemergence of laryngeal squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Oropharyngeal squamous cell carcinoma recurrent

description: Reemergence of squamous cell carcinoma of the oropharynx after a period of remission.


name: Hypopharyngeal squamous cell carcinoma recurrent

description: Reemergence of squamous cell carcinoma of the hypopharynx after a period of remission.


name: Metastatic Thyroid Gland Oncocytic Carcinoma

description: Thyroid gland oncocytic carcinoma that has spread from its original site of growth to another anatomic site.


carcinoma in situ of epiglottis

description: A in situ carcinoma that involves the epiglottis.


Pharyngeal Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of pharyngeal carcinoma according to the American Joint Committee on Cancer, 7th edition.


name: Thyroid Gland Medullary Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of thyroid gland medullary carcinoma, following the rules of the TNM AJCC v7 classification system.


name: mixed medullary-follicular thyroid carcinoma

description: A primary carcinoma of the thyroid gland containing a medullary carcinoma component that is immunohistochemically positive for calcitonin, and follicular carcinoma component that is immunohistochemically positive for thyroglobulin.


tonsillar squamous cell carcinoma

description: A squamous cell carcinoma that arises from the mucosal lining of the tonsil and tends to metastasize early to the lymph nodes. It predominantly affects middle aged and elderly patients who have a history of alcohol and tobacco use. Patients may present with tonsillar swelling, sore throat, pain radiating to the ipsilateral ear, or a neck mass.


name: Stage III Thyroid Gland Follicular Carcinoma AJCC v8

description: Stage III includes: 55 years and older: T4a, Any N, M0. T4a: Gross extrathyroidal extension invading subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve from a tumor of any size. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Advanced Laryngeal Squamous Cell Carcinoma

description: A squamous cell carcinoma of the larynx that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage II Thyroid Gland Papillary Carcinoma AJCC v7

description: Stage II includes: Under 45 years: Any T, Any N, M1.  45 years and older: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  M1: Distant metastasis.  M0: No evidence of distant metastasis.  (from AJCC 7th Ed.)


Laryngeal verrucous carcinoma recurrent

description: The reemergence of verrucous carcinoma of the larynx after a period of remission.


name: Oropharyngeal Poorly Differentiated Carcinoma

description: A high-grade carcinoma that arises from the oropharynx. It is characterized by the presence of malignant cells which bear minimal resemblance to the cells from which they arose.


name: Stage III Thyroid Gland Follicular Carcinoma AJCC v7

description: Stage III includes: (T3, N0, M0); (T1, N1a, M0); (T2, N1a, M0); (T3, N1a, M0). T3: Tumor greater than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues).  T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland.  N0: No regional lymph node metastasis.  N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes).  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Locally Recurrent Oropharyngeal Squamous Cell Carcinoma

description: The reemergence of oropharyngeal squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Stage IVC Pharyngeal Carcinoma

description: Stage IVC carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


papillary thyroid Microcarcinoma

description: A papillary carcinoma of the thyroid gland measuring 10mm or less in diameter. The survival rates of patients with this type of carcinoma are the same with those of the normal population.


name: Stage 0 Nasopharyngeal Undifferentiated Carcinoma AJCC v6, v7, and v8

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


name: Stage IVB Oropharyngeal Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0). T4b: Tumor with very advanced local disease.  Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N3: Tumor with metastasis in a lymph node more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Stage III Differentiated Thyroid Gland Carcinoma AJCC v7


laryngeal carcinoma

description: Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation.


Oropharyngeal Neuroendocrine Carcinoma

description: An extremely rare neuroendocrine carcinoma that arises from the oropharynx.


Epiglottic Squamous Cell Carcinoma

description: A squamous cell carcinoma of the larynx that arises from the epiglottis.


name: Stage IVB Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v8

description: Stage IVB includes: (T1-T3a, N1, M0); (T3b, Any N, M0); (T4, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. T4: Tumor of any size with gross extrathyroidal extension. N1: Metastasis to regional nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage II Differentiated Thyroid Gland Carcinoma Under 55 Years AJCC v8

description: Stage II includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7


name: Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7

description: Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3, M0); IVC (Any T, Any N, M1). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa.  Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho.  It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder.  This would include caudal portions of levels IV and VB.  All cases with lymph nodes (whole or part) in the fossa are considered N3b.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


name: Oropharyngeal Large Cell Neuroendocrine Carcinoma

description: An extremely rare large cell neuroendocrine carcinoma that arises from the oropharynx.


Refractory Nasopharyngeal Carcinoma

description: Nasopharyngeal carcinoma that is resistant to treatment.


name: Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage III Hypopharyngeal Carcinoma AJCC v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor measuring more than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 7th ed.)


name: Locally Advanced Thyroid Gland Oncocytic Carcinoma

description: Thyroid gland oncocytic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7

description: Stage IVB includes: (T4b, Any N, M0); (Any T, N3, M0).  T4b: Supraglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Glottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures. Subglottis: Very advanced local disease.  Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.  N3: Metastasis in a lymph node, more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Advanced Oropharyngeal Squamous Cell Carcinoma

description: A squamous cell carcinoma of the oropharynx that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage I includes: (T0, N0, M0); (T0, N1, M0); (T1, N0, M0); (T1, N1, M0); (T2, N0, M0); (T2, N1, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or more ipsilateral lymph nodes, none larger than 6 cm. M0: No distant metastasis. (AJCC 8th ed.)


name: Unresectable Thyroid Gland Oncocytic Carcinoma

description: Thyroid gland oncocytic carcinoma that is not amenable to surgical resection.


name: Stage II Oropharyngeal (p16-Negative) Carcinoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Squamous cell carcinoma of the hypopharynx stage IV

description: A squamous cell carcinoma of the hypopharynx that has spread from the original site of growth to another anatomic site.


name: Stage II Thyroid Gland Follicular Carcinoma 55 Years and Older AJCC v8

description: Stage II includes: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Oncocytic Variant Thyroid Gland Papillary Carcinoma

description: A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of papillary or follicular structures, containing malignant follicular cells with abundant granular eosinophilic cytoplasm. These cells have the nuclear features that characterize the papillary carcinomas of the thyroid gland.


name: Recurrent Hereditary Thyroid Gland Medullary Carcinoma

description: The reemergence of hereditary thyroid gland medullary carcinoma after a period of remission.


thyroid gland squamous cell carcinoma

description: A rapidly growing primary carcinoma of the thyroid gland composed of malignant squamous cells. The clinical course is usually aggressive.


name: Advanced Pharyngeal Squamous Cell Carcinoma

description: Pharyngeal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IVB Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7

description: Stage IVB includes: Any T, N3, M0.  N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa.  Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho.  It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder.  This would include caudal portions of levels IV and VB.  All cases with lymph nodes (whole or part) in the fossa are considered N3b.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood Thyroid Gland Follicular Carcinoma

description: A follicular thyroid gland carcinoma occurring in childhood.


name: Oropharyngeal squamous cell carcinoma stage I

description: Stage I includes: T1, N0, M0.  T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Stage I Nasopharyngeal Carcinoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IV Nasopharyngeal Carcinoma AJCC v6

description: Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3, M0); IVC (Any T, Any N, M1). T4: Tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, orbit, or masticator space.  N3: Metastasis in a lymph node(s).  N3a: greater than 6 cm in dimension.  N3b: extension to the supraclavicular fossa.  M1: Distant metastasis. (AJCC 6th ed.)


name: Thyroid Gland Anaplastic Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of thyroid gland anaplastic carcinoma, following the rules of the TNM AJCC v8 classification system.


Tonsillar Undifferentiated Carcinoma

description: A non-keratinizing carcinoma arising from the tonsil.  It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate.


name: Thyroid Gland Follicular Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of follicular thyroid gland carcinoma, following the rules of the TNM AJCC v7 classification system.


name: Stage III Laryngeal Cancer AJCC v6 and v7

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Supraglottis: Tumor limited to one subsite of supraglottis with normal vocal cord mobility. Glottis: Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility.  Subglottis: Tumor limited to the subglottis.  T2: Supraglottis: Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx.  Glottis: Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility.  Subglottis: Tumor extends to vocal cord(s) with normal or impaired mobility. T3: Supraglottis: Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, pre-epiglottic tissues, paraglottic space, and/or inner cortex of thyroid cartilage.  Glottis: Tumor limited to the larynx with vocal cord fixation and/or invasion of paraglottic space, and/or inner cortex of the thyroid cartilage.  Subglottis: Tumor limited to larynx with vocal cord fixation.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3cm or less in greatest dimension.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Alcohol-Related Laryngeal Carcinoma

description: A carcinoma that arises from the larynx and is caused by alcohol abuse.


name: Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)


name: Stage II Differentiated Thyroid Gland Carcinoma AJCC v8

description: Stage II includes: Under 55 years: Any T, Any N, M1; 55 years and older: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Stage 0 Laryngeal Verrucous Carcinoma AJCC v6, v7, and v8

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


Pharyngeal cancer stage I

description: Stage I carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions.


name: Stage I Thyroid Gland Papillary Carcinoma 55 Years and Older AJCC v8

description: Stage I includes: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage IV Nasopharyngeal Carcinoma

description: A carcinoma that arises from the nasopharynx and has metastasized to another anatomic site.


name: Advanced Nasopharyngeal Squamous Cell Carcinoma

description: A squamous cell carcinoma of the nasopharynx that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Tonsillar Squamous Cell Carcinoma

description: Tonsillar squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of HPV-mediated (p16-positive) oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Locally Advanced Parathyroid Gland Carcinoma

description: A parathyroid gland carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Nasopharyngeal Carcinoma

description: Nasopharyngeal carcinoma that is not amenable to surgical resection.


name: Unresectable Hypopharyngeal Squamous Cell Carcinoma

description: Hypopharyngeal squamous cell carcinoma that is not amenable to surgical resection.


name: Stage III Hypopharyngeal Carcinoma AJCC v8

description: Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor larger than 4 cm in greatest dimension or with fixation of hemilarynx or extension to esophagus. T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or smaller in greatest dimension. T2: Tumor invading more than one subsite of hypopharynx or an adjacent site, or measuring more than 2 cm but not more than 4 cm in greatest dimension without fixation of hemilarynx. N0: No regional lymph node metastasis. N1: Tumor with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (-). M0: No distant metastasis. (AJCC 8th ed.)


name: Unresectable Thyroid Gland Anaplastic Carcinoma

description: Thyroid gland anaplastic carcinoma that is not amenable to surgical resection.


name: Stage II Nasopharyngeal Carcinoma AJCC v8

description: Stage II includes: (T1, N1, M0); (T0, N1, M0); (T2, N0, M0); (T2, N1, M0). T1: Tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal involvement. T0: No tumor identified, but EBV-positive cervical node(s) involvement is present. T2: Tumor with extension to parapharyngeal space, and/or adjacent soft tissue involvement (medial pterygoid, lateral pterygoid, prevertebral muscles). N0: No regional lymph node metastasis. N1: Tumor with unilateral metastasis in cervical lymph node(s), and/or unilateral or bilateral metastasis in retropharyngeal lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IVC Differentiated Thyroid Gland Carcinoma AJCC v7


name: Hypopharyngeal Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of hypopharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.


name: Nasopharyngeal Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the nasopharynx and is characterized by prominent production of keratin.


Laryngeal Basaloid Carcinoma

description: An aggressive variant of squamous cell carcinoma that arises from the pyriform sinus or supraglottic area.  It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.  Comedonecrosis may be present.  An in situ or invasive keratinizing squamous cell carcinoma component is always present.  Signs and symptoms include hoarseness, dysphagia, pain, and neck mass.


Pharyngeal Carcinoma by AJCC v6 Stage

description: A term that refers to the staging of pharyngeal carcinoma according to the American Joint Committee on Cancer, 6th edition.


thyroid gland adenocarcinoma

description: An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation).


Stage IVA Laryngeal Cancer AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); T4a: Supraglottis: Moderately advanced local disease.  Tumor invades through the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Glottis: Moderately advanced local disease. Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). Subglottis: Moderately advanced local disease.  Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus).  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.  N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 7th ed.)


name: Stage II Differentiated Thyroid Gland Carcinoma Under 45 Years AJCC v7

description: Stage II includes: Any T, Any N, M1.  M1: Distant metastasis.  (from AJCC 7th Ed.)


name: Stage II Laryngeal Cancer AJCC v6 and v7

description: Stage II includes: T2, N0, M0. T2: (Supraglottis) Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of base of tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx.  (Glottis) Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility.  (Subglottis) Tumor extends to vocal cord(s) with normal or impaired mobility. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Classic Thyroid Gland Papillary Carcinoma

description: A thyroid gland papillary carcinoma characterized by the presence of thin cores of fibrovascular tissue lined by one or occasionally several layers of malignant cells with distinct nuclear features that include nuclear pseudoinclusions, nuclear grooves, and ground glass nuclear inclusions.


supraglottis squamous cell carcinoma

description: A squamous cell carcinoma of the larynx that arises from the supraglottic area. Signs and symptoms include dysphagia, a sensation of foreign body in the throat, and hemoptysis. It spreads to the space anterior to the epiglottis, pyriform sinus, and base of the tongue.


Stage IV Oropharyngeal Carcinoma

description: Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: Tumor invades the larynx, deep/extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible. T4b: Tumor invades lateral pterygoid muscle, pterygoid plates lateral nasopharynx, or skull base or encases carotid artery. M1: Distant Metastasis. (AJCC 6th ed.)


laryngeal adenoid cystic carcinoma

description: A rare adenoid cystic carcinoma of the larynx. It usually arises from the supraglottic or subglottic area. It is characterized by slow progression and late distant metastases.


Hypopharyngeal Verrucous Carcinoma

description: An exophytic, warty, well differentiated, slow growing and non-metastasizing squamous cell carcinoma arising from the hypopharynx.


name: Stage 0 Hypopharyngeal Squamous Cell Carcinoma AJCC v6, v7, and v8

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


differentiated thyroid carcinoma

description: Differentiated thyroid carcinoma (DTC), also known as papillary or follicular thyroid carcinoma, is a slow-growing malignancy usually presenting in adults as an asymptomatic thyroid mass.


name: Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7

description: Stage IVC includes: Any T, Any N, M1.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Laryngeal Acantholytic Squamous Cell Carcinoma

description: A rare variant of squamous cell carcinoma that arises from the larynx.  It is characterized by acantholysis of the tumor cells that results in the formation of pseudolumina that resemble glandular structures.


description: A nasopharyngeal carcinoma characterized by the lack of keratinization and the presence of a dense lymphoplasmacytic infiltrate.  It is subdivided into undifferentiated and differentiated types, based on the cytologic features of the malignant cells.  The undifferentiated type is characterized by the presence of cells with large vesicular nuclei with prominent nucleoli and a syncytial pattern of growth.  The differentiated type is characterized by the presence of smaller cells and cellular stratification reminiscent of transitional cell carcinoma.  While morphologically distinct, both types have similar clinical presentation and prognosis.


larynx carcinoma in situ

description: A in situ carcinoma that involves the larynx.


Nasopharyngeal Basaloid Carcinoma

description: An aggressive variant of squamous cell carcinoma that arises from the nasopharynx.  It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.  Comedonecrosis may be present.


name: Stage IVA Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7

description: Stage IVA includes: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)


name: Sporadic Thyroid Gland Micromedullary Carcinoma

description: A sporadic thyroid gland medullary carcinoma measuring less than 10mm in diameter.


name: Stage IV Nasopharyngeal Carcinoma AJCC v7

description: Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3, M0); IVC (Any T, Any N, M1). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space.  N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension.  Midline nodes are considered ipsilateral nodes.  N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  Midline nodes are considered ipsilateral nodes. N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa.  Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho.  It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder.  This would include caudal portions of levels IV and VB.  All cases with lymph nodes (whole or part) in the fossa are considered N3b.  M0: No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.)


name: Recurrent Differentiated Thyroid Gland Carcinoma

description: The reemergence of differentiated thyroid gland carcinoma after a period of remission.


name: Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7

description: Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB: (T4b, Any N, M0); (Any T, N3, M0); IVC: (Any T, Any N, M1).  T4a: Tumor with moderately advanced local disease.  Tumor invades the thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue.  Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  T3: Tumor measuring more than 4 cm in greatest dimension or tumor with fixation of hemilarynx or extension to esophagus.  T4b: Tumor with very advanced local disease.  Tumor invades prevertebral fascia, encases carotid artery, or involves mediastinal structures.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 7th ed.)


name: Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v8

description: Stage IVB includes: 55 years and older: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


name: Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

description: Stage II includes: (T0, N2, M0); (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis. T4: Moderately advanced local disease. Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible or beyond. Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of the larynx. N0: No regional lymph node metastasis. N1: Tumor with metastasis in four or fewer lymph nodes.  N2: Tumor with metastasis in more than four lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage I Thyroid Gland Papillary Carcinoma AJCC v8

description: Stage I includes: Under 55 years: Any T, Any N, M0. 55 years and older: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8

description: Stage IVA includes: (T4a, Any N, M0); (T1-3, N1b, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but less than 4 cm in greatest dimension limited to the thyroid. T3: Tumor measuring 4 cm or more in greatest dimension or with extrathyroidal extension. T4a: Moderately advanced disease; tumor of any size with gross extrathyroidal extension into the nearby tissues of the neck, including subcutaneous soft tissue, larynx, trachea, esophagus, or recurrent laryngeal nerve. N1b: Metastasis to unilateral, bilateral, or contralateral lateral neck lymph nodes levels I, II, III, IV, or V or retropharyngeal lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Stage IVC Hypopharyngeal Carcinoma AJCC v8

description: Stage IVC includes: Any T, Any N, M1. M1: distant metastasis. (AJCC 8th ed.)


Laryngeal Giant Cell Carcinoma

description: A rare undifferentiated carcinoma that arises from the larynx.  It is characterized by the presence of multiple bizarre multinucleated giant cells.  The prognosis is poor.


name: Stage 0 Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v6, v7, and v8

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th, 7th, and 8th eds.)


name: HPV positive oropharyngeal squamous cell carcinoma

description: A squamous cell carcinoma that arises from the oropharynx and is associated with human papillomavirus type 16 infection.


name: Refractory Laryngeal Squamous Cell Carcinoma

description: Laryngeal squamous cell carcinoma that does not respond to treatment.


name: Stage I Thyroid Gland Follicular Carcinoma 55 Years and Older AJCC v8

description: Stage I includes: (T1, N0/NX, M0); (T2, N0/NX, M0).  T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. N0: No evidence of locoregional lymph node metastasis. NX: Regional lymph nodes cannot be assessed. M0: No distant metastasis. (from AJCC 8th Ed.)


Unresectable Thyroid Gland Carcinoma

description: A carcinoma that arises from the thyroid gland and is not amenable to surgical resection.


laryngeal small cell carcinoma

description: A rare carcinoma that arises from the larynx. It is characterized by the presence of small neuroendocrine cells. It metastasizes early and has an aggressive clinical course.


Nasopharyngeal cancer recurrent

description: The reemergence of nasopharyngeal carcinoma after a period of remission.


name: Stage IV Thyroid Gland Medullary Carcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, Any N, M0); (T1-3, N1b, M0); IVB: (T4b, Any N, M0); IVC: (Any T, Any N, M1). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but less than 4 cm in greatest dimension limited to the thyroid. T3: Tumor measuring 4 cm or more in greatest dimension or with extrathyroidal extension. T4a: Moderately advanced disease; tumor of any size with gross extrathyroidal extension into the nearby tissues of the neck, including subcutaneous soft tissue, larynx, trachea, esophagus, or recurrent laryngeal nerve. T4b: Very advanced disease; tumor of any size with extension towards the spine or into nearby large blood vessels, invading the prevertebral fascia, or encasing the carotid artery or mediastinal vessels. N1b: Metastasis to unilateral, bilateral, or contralateral lateral neck lymph nodes levels I, II, III, IV, or V or retropharyngeal lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (from AJCC 8th Ed.)


name: thyroid gland diffuse sclerosing papillary carcinoma

description: A morphologic variant of papillary carcinoma of the thyroid gland that more often affects young patients and commonly metastasizing to the lungs. It is characterized by a diffuse infiltration of the thyroid gland by malignant follicular cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration.


name: Refractory Thyroid Gland Follicular Carcinoma

description: Thyroid gland follicular carcinoma that is resistant to treatment.


name: Oropharyngeal Human Papillomavirus-Negative Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the oropharynx and lacks association with human papillomavirus type 16 infection.


name: Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7

description: Stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Tumor with moderately advanced local disease.  Tumor invades the thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue.  Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat.  T1: Tumor limited to one subsite of hypopharynx and/or 2 cm or less in greatest dimension.  T2: Tumor invades more than one subsite of the hypopharynx or an adjacent site, or measures more than 2 cm but not more than 4 cm in greatest diameter without fixation of hemilarynx.  T3: Tumor measuring more than 4 cm in greatest dimension or tumor with fixation of hemilarynx or extension to esophagus.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IVB Nasopharyngeal Carcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


name: Oropharyngeal Keratinizing Squamous Cell Carcinoma

description: An oropharyngeal squamous cell carcinoma characterized by the presence of keratinization and intercellular bridges.


Posterior Pharyngeal Wall Carcinoma

description: A carcinoma that arises from the posterior wall of the pharynx.


name: Nasopharyngeal squamous cell carcinoma stage I

description: Stage I includes: T1, N0, M0. T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension.  Parapharyngeal extension denotes posterolateral infiltration of tumor. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)