name: Small Lymphocytic Lymphoma with Plasmacytoid Differentiation

description: A small lymphocytic lymphoma characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


Intestinal T-Cell Lymphoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A group of mature T-cell and NK-cell non-Hodgkin lymphomas that includes enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, and intestinal T-cell lymphoma, not otherwise specified. Most of these lymphomas arise from the small intestine and a minority from the large intestine or stomach.


name: Head and Neck Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the head and neck region. It affects both lymph nodes and extranodal sites. The most frequently affected extranodal site is the Waldeyer ring, particularly the palatine tonsil.


Duodenal-type follicular lymphoma

description: A localized low-grade follicular lymphoma within the gastrointestinal tract, which is distinct from other gastrointestinal tract follicular lymphomas.  It has features that overlap with in situ follicular neoplasia as well as some features resembling an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. The prognosis is excellent.


name: Lymphoplasmacytoid lymphoma/immunocytoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Oropharyngeal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the oropharynx.


name: Stage I Indolent Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Mantle cell lymphoma recurrent

description: The reemergence of a mantle cell lymphoma after a period of remission.


name: Lugano Classification Stage II Bulky Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


name: Lymphomatous Adult T-Cell Leukemia/Lymphoma

description: An adult T-cell leukemia/lymphoma characterized by generalized lymphadenopathy without peripheral blood involvement.  Most patients have advanced disease, however hypercalcemia is not frequently present.


name: Pleomorphic Variant Mantle Cell Lymphoma

description: An aggressive mantle cell lymphoma characterized by the presence of pleomorphic neoplastic B-lymphocytes.


Burkitt's lymphoma of spleen

description: Burkitt lymphoma that involves the spleen.


name: Stage IV Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: Initial CNS and/or bone marrow involvement. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Major Salivary Gland Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the parotid gland, submandibular gland, or sublingual gland.  Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


name: Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Lymphoplasmacytoid lymphoma/immunocytoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Recurrent NK-Cell Lymphoma, Unclassifiable

description: The reemergence of NK-cell lymphoma, unclassifiable after a period of remission.


name: Diffuse large B-cell lymphoma, unclassifiable, NOS

description: A biologic subset of diffuse large B-cell lymphomas (DLBCL) that do not overexpress the genes whose overexpression characterizes the germinal center B-cell-like and activated B-cell-like DLBCL.  Morphologically, these lymphomas are either immunoblastic or centroblastic.  Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome, similar to those with an activated B-cell-like gene expression profile.


name: Recurrent Follicular Helper T-Cell Lymphoma, Follicular-Type

description: The reemergence of follicular helper T-cell lymphoma, follicular-type after a period of remission.


name: Stage IVA2 Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IVA2 includes: T1-4, N3, M0, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


mycosis fungoides variant

description: A header term that includes the rare following variants of mycosis fungoides: folliculotropic mycosis fungoides, granulomatous slack skin disease, and pagetoid reticulosis.


Primary Bone Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.  The femur, spine, and pelvic bones are the most frequently affected areas.  The majority of cases are diffuse large B-cell lymphomas.  Most patients present with pain in the affected area.  Systemic symptoms are rare.


name: Recurrent Primary Vitreoretinal Non-Hodgkin Lymphoma

description: The reemergence of primary vitreoretinal non-Hodgkin lymphoma after a period of remission.


name: Stage I Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage I includes: IA (T1, N0, M0, B0,1); IB (T2, N0, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Methotrexate-Associated Peripheral T-Cell Lymphoma

description: A peripheral T-cell lymphoma that develops in patients who are immunosuppressed with methotrexate.


intravascular large B-cell lymphoma

description: Intravascular large B-cell lymphoma (IVLBCL) is a very rare form of diffuse large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of small blood vessels (especially the capillaries) that most often presents with a wide range of clinical manifestations (as potentially any tissue can be involved), with patients from Western countries more frequently manifesting with neurological and cutaneous symptoms while patients from Asian countries more frequently displaying hepatosplenomegaly and thrombocytopenia. IVLBCL is characterized by an absence of lymphadenopathy, an aggressive clinical course and a poor prognosis.


name: Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: Diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


Refractory Lymphoblastic Lymphoma

description: Lymphoblastic lymphoma that is resistant to treatment.


name: Ann Arbor Stage II Grade 2 Non-Contiguous Follicular Lymphoma


Refractory Grade 3b Follicular Lymphoma

description: Grade 3b follicular lymphoma that is resistant to treatment.


Stage IV Adult Lymphoblastic Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Small Intestinal Monomorphic Epitheliotropic T-Cell Lymphoma

description: A monomorphic epitheliotropic intestinal T-cell lymphoma arising from the small intestine. It is characterized by the presence of a monomorphic cellular infiltrate of small to medium-sized T-lymphocytes that are cytotoxic and express CD56. It is not associated with celiac disease.


Methotrexate-Related Burkitt Lymphoma

description: A Burkitt lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage II includes: IIA (T1,2, N1,2, M0, B0,1); IIB (T3, N0-2, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Recurrent Extranodal Diffuse Large B-cell Lymphoma

description: The reemergence of extranodal diffuse large B-cell lymphoma after a period of remission.


name: Nodal marginal zone B-cell lymphoma stage IV


Cutaneous Burkitt Lymphoma

description: Burkitt lymphoma that affects the skin.


large B-cell diffuse lymphoma of heart

description: A diffuse large B-cell lymphoma that arises from the heart.


name: large B-cell diffuse lymphoma of accessory sinus

description: A non-Hodgkin lymphoma that arises from the paranasal sinus and is characterized by the presence of a diffuse malignant infiltrate composed of large B-lymphocytes.


name: Ann Arbor Stage III Grade 2 Follicular Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IIA includes:  T1-2, N1,2, M0, B0,1. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Digestive System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


name: Ann Arbor Stage II Contiguous Adult Lymphoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Non-Hodgkin's lymphoma transformed recurrent

description: The reemergence of non-Hodgkin lymphoma transformed after a period of remission.


name: Recurrent Anaplastic Large Cell Lymphoma

description: The reemergence of anaplastic large cell lymphoma after a period of remission.


Marginal zone lymphoma stage II

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ)


name: Esophageal Diffuse Large B-Cell Lymphoma

description: An extranodal diffuse large B-cell lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus.


name: Angioimmunoblastic T-cell lymphoma refractory

description: Follicular helper T-cell lymphoma, angioimmunoblastic-type that is resistant to treatment.


name: Refractory Indolent Adult Non-Hodgkin Lymphoma

description: Indolent adult non-Hodgkin lymphoma that is resistant to treatment.


Childhood Lymphoblastic Lymphoma

description: A lymphoblastic lymphoma occurring in children.


description: A follicular lymphoma that develops in patients who are immunosuppressed with methotrexate.


name: Mantle Cell Lymphoma with CCND2 Rearrangement

description: Mantle cell lymphoma characterized by the presence of CCND2 gene rearrangement. A small number of cases express this gene rearrangement and not CCND1 gene rearrangement.


name: Recurrent High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements

description: The reemergence of high-grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements after a period of remission.


name: Stage IVB Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


name: Advanced Unfavorable Non-Hodgkin Lymphoma

description: A clinical stage II or IV non-Hodgkin lymphoma with at least four of the following risk factors: albumin level less than 4.0 g/dl, hemoglobin level of less than 10.5 g/dl, male sex, forty-five years of age or older, stage IV disease, white cell count of at least 15,000 per cubic millimeter, absolute lymphocytic count of less than 600 per cubic millimeter or a lymphocytic count of less than 8% of the total white cell count.


name: Recurrent High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

description: The reemergence of high-grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements after a period of remission.


name: Cutaneous Adult T-Cell Leukemia/Lymphoma

description: Adult T-cell leukemia/lymphoma affecting the skin.


Recurrent Plasmablastic Lymphoma

description: The reemergence of plasmablastic lymphoma after a period of remission.


name: primary mediastinal large B-cell lymphoma

description: A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis. Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001)


name: Stage I Childhood Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Endometrial Mucosa-Associated Lymphoid Tissue Lymphoma

description: A rare extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue affecting the endometrium.


NK-Cell Lymphoma, Unclassifiable

description: A very rare NK-cell lymphoma with pathologic and clinical features posing difficulty in its exact diagnosis and classification.


name: Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive

description: An anaplastic large cell lymphoma, ALK-positive, arising from the central nervous system.


name: large B-cell diffuse lymphoma of nasal cavity

description: A non-Hodgkin lymphoma that arises from the nasal cavity and is characterized by the presence of a diffuse malignant infiltrate composed of large B-lymphocytes.


name: St. Jude Stage IV Childhood Non-Hodgkin Lymphoma AJCC v8

description: Stage IV: Any tumor, with initial CNS and/or bone marrow involvement. (from AJCC 8th Ed.)


name: St. Jude Childhood Non-Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for childhood non-Hodgkin Lymphomas based on the St. Jude Children's Research Hospital staging system. The Ann Arbor staging system has been found to be inappropriate for staging of the non-Hodgkin lymphomas of childhood. The St. Jude staging system has been widely accepted for more than three decades and remains the recommended staging system for childhood non-Hodgkin lymphomas. (from AJCC 8th Ed.)


Marginal zone lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Recurrent Adult Grade III Lymphomatoid Granulomatosis

description: The reemergence of grade III lymphomatoid granulomatosis in adulthood after a period of remission.


mediastinal gray zone lymphoma

description: A mediastinal lymphoma with molecular, morphologic, immunophenotypic, and clinical features of both mediastinal (thymic) large B-cell lymphoma and classical Hodgkin lymphoma. The identification of this group of lymphomas, along with recent gene expression profiling results (PDL2 gene expression in both mediastinal (thymic) large B-cell lymphoma tissues and Hodgkin lymphoma cell lines), further supports the hypothesis that mediastinal (thymic) large B-cell lymphomas and classical Hodgkin lymphomas are related entities.


name: Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: The reemergence of diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma, after a period of remission.


name: Ann Arbor Stage III Nodular Lymphocyte Predominant B-Cell Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Refractory Extranodal Diffuse Large B-cell Lymphoma

description: Extranodal diffuse large B-cell lymphoma that is resistant to treatment.


name: Ann Arbor Stage II Childhood Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Diffuse large B-cell lymphoma that resulted from the transformation of indolent B-cell non-Hodgkin lymphoma and is resistant to treatment.


angioimmunoblastic T-cell lymphoma

description: A mature T-cell non-Hodgkin lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes and extranodal sites. The clinical course is typically aggressive.


name: Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

description: Monomorphic epitheliotropic intestinal T-cell lymphoma that is resistant to treatment.


name: Adult Grade III Lymphomatoid Granulomatosis

description: Grade III lymphomatoid granulomatosis that occurs in adulthood.


Cyclin D1-Negative Mantle Cell Lymphoma

description: A molecular subtype of mantle cell lymphoma characterized by the absence of cyclin D1 expression and CCND1 rearrangement.


name: Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma

description: The reemergence of an aggressive B-cell non-Hodgkin lymphoma after a period of remission.


Peritoneal Primary Effusion Lymphoma

description: Primary effusion lymphoma that affects the peritoneal cavity. The majority of patients are HIV-positive men.


name: T-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for T-cell non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Sezary syndrome

description: Sezary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sezary cells).


Non-Hodgkin's lymphoma of prostate

description: A rare non-Hodgkin lymphoma that arises from the prostate gland.


name: Lymphoma, Small Cleaved-Cell, Follicular

description: A follicular lymphoma which contains up to 5 centroblasts per 40X high-power microscopic field.


name: Noncutaneous Childhood Anaplastic Large Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for noncutaneous childhood anaplastic large cell lymphoma based on the Ann Arbor classification criteria.


Advanced Favorable Non-Hodgkin Lymphoma

description: A clinical stage II or IV non-Hodgkin lymphoma with up to three of the following risk factors: albumin level less than 4.0 g/dl, hemoglobin level of less than 10.5 g/dl, male sex, forty-five years of age or older, stage IV disease, white cell count of at least 15,000 per cubic millimeter, absolute lymphocytic count of less than 600 per cubic millimeter or a lymphocytic count of less than 8% of the total white cell count.


name: Large B-cell lymphoma with IRF4 rearrangement

description: A large B-cell lymphoma that usually affects the Waldeyer ring and/or cervical lymph nodes and less often the gastrointestinal tract. It occurs most commonly in children and young adults and is low stage. It is characterized by a follicular, follicular and diffuse, or pure diffuse growth pattern resembling follicular lymphoma grade 3B or a diffuse large B-cell lymphoma. Most cases have IG/IRF4 rearrangements. BCL2 rearrangements are not present. Some cases that belong in this category lack an IRF4 rearrangement but have strong IRF4/MUM1 expression. This lymphoma is more aggressive than pediatric-type follicular lymphomas.


Angiocentric lymphoma recurrent

description: The reemergence of nasal type extranodal NK/T-cell lymphoma after a period of remission.


Stage IV Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Refractory Immunoblastic Lymphoma

description: Immunoblastic lymphoma that is resistant to treatment.


name: Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a follicular lymphoma to an aggressive diffuse large B-cell lymphoma.


Classical Burkitt Lymphoma

description: A Burkitt lymphoma characterized by the presence of a uniform malignant lymphocytic infiltrate that is composed of medium-sized cells with round nuclei and multiple basophilic nucleoli, abundant mitotic figures, and a starry-sky pattern due to the presence of multiple tangible body macrophages.


name: Precursor B-lymphoblastic lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Splenic marginal zone lymphoma refractory

description: Splenic marginal zone lymphoma that is resistant to treatment.


N1 diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is categorized as N1 with high probability by the LymphGen algorithm. This is based on a combination of genetic features. Although N1 DLBCLs always have an activating mutation affecting NOTCH1, LymphGen can assign cases with this mutation to other classes, depending on the presence of other genetic features.


name: Immunoblastic lymphoma associated with AIDS

description: A morphologic variant of diffuse large B-cell lymphoma occurring in HIV-positive patients.


Peripheral T-Cell Lymphoma-TBX21

description: A molecular subtype of peripheral T-cell lymphoma, not otherwise specified, characterized by high expression of T-box 21 (TBX21). It is composed of a polymorphic lymphocytic infiltrate admixed with abundant inflammatory cells and is associated with a better prognosis compared to peripheral T-cell lymphoma-GATA3.


name: Secondary Choroidal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that has spread to the choroid following the initial presentation in another nodal or extranodal site.


name: Refractory ALK-Positive Large B-Cell Lymphoma

description: ALK-positive large B-cell lymphoma that is resistant to treatment.


Stage III Burkitt Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Follicular lymphoma refractory

description: Follicular lymphoma grade I, II, III that is resistant to treatment.


Follicular lymphoma recurrent

description: The reemergence of follicular lymphoma after a period of remission.


name: Limited Stage Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: No involvement of CNS and no involvement of bone marrow. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


lymphoplasmacytic lymphoma

description: A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein.


T-cell lymphoma recurrent

description: The reemergence of T-cell non-Hodgkin lymphoma after a period of remission.


name: Lugano Classification Adult Non-Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for adult non-Hodgkin lymphomas based on the Lugano classification criteria. This staging system does not apply to ocular adnexal lymphomas (are staged according to the classification for ocular adnexal lymphoma), pediatric non-Hodgkin lymphomas (are staged according to the St. Jude Children's Research Hospital staging system), primary cutaneous lymphomas (are staged according to the classification for primary cutaneous lymphoma), and multiple myelomas (are staged according to the classification for plasma cell myeloma). (from AJCC 8th Ed.)


name: Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified

description: High-grade B-cell lymphoma, not otherwise specified, that is resistant to treatment.


name: Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1,000 per microliter or more Sezary cells with positive clone. (AJCC 8th ed.)


name: Lacrimal Drainage System Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the lacrimal sac.


aggressive B-cell non-Hodgkin lymphoma

description: A B-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes B lymphoblastic lymphoma, subtypes of diffuse large B-cell lymphoma, Burkitt lymphoma, grade 3 follicular lymphoma, and mantle cell lymphoma.


name: Recurrent Intravascular Large B-Cell Lymphoma

description: The reemergence of intravascular large B-cell lymphoma after a period of remission.


name: Mycosis fungoides/Sezary syndrome stage IV

description: Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.  M0: No visceral organ involvement.  M1: Visceral involvement (must have pathology confirmation and organ involved should be specified).  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.  (AJCC 7th ed.)


name: Primary Large B-Cell Lymphoma of Immune-Privileged Site

description: A term that refers to diffuse large B-cell lymphomas that arise as primary tumors in the central nervous system, vitreoretina, and testis in immunocompetent patients.


name: Parotid Gland Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that manifests initially in the parotid gland.


Gastric T-Cell Non-Hodgkin Lymphoma

description: A rare, extranodal T-cell non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


B-cell lymphoma recurrent

description: The reemergence of B-cell non-Hodgkin lymphoma after a period of remission.


Advanced Marginal Zone Lymphoma

description: Marginal zone lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: childhood nasal type extranodal NK/T-cell lymphoma

description: A nasal type extranodal NK/T-cell lymphoma occurring in childhood.


name: Advanced Transformed Non-Hodgkin Lymphoma

description: Transformed non-Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Primary Cutaneous Intravascular Large B-Cell Lymphoma

description: Intravascular large B-cell lymphoma that arises from the skin.


B-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of peripheral T-cell lymphoma, not otherwise specified after a period of remission.


name: Nodal marginal zone B-cell lymphoma recurrent

description: The reemergence of nodal marginal zone lymphoma after a period of remission.


name: Campylobacter Jejuni-Associated Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the small intestine and it is associated with Campylobacter jejuni infection.


Centroblastic lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the esophagus with the bulk of the mass located in the esophagus.


Recurrent Grade 3a Follicular Lymphoma

description: The reemergence of grade 3a follicular lymphoma after a period of remission.


Sporadic Burkitt's lymphoma

description: A clinical variant of Burkitt lymphoma that occurs throughout the world.  It affects both children and adults and is more frequently seen in males.


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage I

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage I disease.


name: Lugano Classification Stage I Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


Head and Neck Follicular Lymphoma

description: A follicular lymphoma that arises from the head and neck region. It usually affects older individuals, and the most common sites of involvement are the cervical lymph nodes and Waldeyer ring.


Adult T-cell lymphoma/leukemia stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Primary Pituitary Gland Diffuse Large B-Cell Lymphoma

description: A rare diffuse large B-cell lymphoma that arises from the pituitary gland.


name: Recurrent Childhood Anaplastic Large Cell Lymphoma

description: The reemergence of anaplastic large cell lymphoma in childhood after a period of remission.


name: Precursor B-lymphoblastic lymphoma refractory

description: B-lymphoblastic lymphoma that does not respond to treatment.


name: Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the ocular adnexa. It is the most common type of primary ocular adnexal lymphoma.


Anaplastic large B-cell lymphoma

description: A diffuse large B-cell lymphoma variant characterized by the presence of large round, oval, or polygonal cells with bizarre pleomorphic nuclei resembling Hodgkin or Reed-Sternberg cells. It is unrelated to anaplastic large cell lymphoma which is a T-cell non-Hodgkin lymphoma.


name: Stage III Childhood Lymphoblastic Lymphoma

description: Stage III: Tumors or involved lymph node areas occur on both sides of the diaphragm. Stage III also includes any primary intrathoracic (mediastinal, pleural, or thymic) disease, extensive primary intra-abdominal disease, or any paraspinal or epidural tumors (from PDQ).


Diffuse large B-cell lymphoma recurrent

description: The reemergence of diffuse large B-cell lymphoma after a period of remission.


name: Ann Arbor Stage IV Nodular Lymphocyte Predominant B-Cell Lymphoma


name: Dural Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

description: A rare, primary marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the meningeal dura.  The majority of cases have been described in middle aged women.  Radiologically, the lymphomatous dural infiltration mimics meningioma.


Recurrent Indolent Non-Hodgkin Lymphoma

description: The reemergence of indolent non-Hodgkin lymphoma after a period of remission.


Adult Immunoblastic Lymphoma

description: A morphologic variant of diffuse large B-cell lymphoma occurring in adults.  It is characterized by the presence of large lymphoid cells with abundant cytoplasm and prominent nucleoli.


Stage II Adult Lymphoblastic Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Transformed Small Lymphocytic Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a small lymphocytic lymphoma to an aggressive diffuse large B-cell lymphoma.


name: B Lymphoblastic Lymphoma by Ann Arbor Stage

description: An anatomic stage for B-lymphoblastic lymphoma based on the Ann Arbor classification criteria.


T-lymphoblastic lymphoma

description: The most frequent type of lymphoblastic lymphoma. It comprises approximately 85-90% of cases. It is more frequently seen in adolescent males. It frequently presents with a mass lesion in the mediastinum. Pleural effusions are common. (WHO, 2001)


intraocular lymphoma

description: A lymphoma that arises within the eye. Signs and symptoms include decreased vision, uveitis, and vitreous floaters.


name: Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IIIB includes: T4, N0-2, M0, B1. T4: Confluence of erythema covering 80% or more of body surface area.  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

description: The reemergence of primary diffuse large B-cell lymphoma of the central nervous system after a period of remission.


name: Ann Arbor Stage II Non-Contiguous Aggressive Adult Non-Hodgkin Lymphoma


Childhood Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that occurs during childhood.


Parotid Gland Mantle Cell Lymphoma

description: A mantle cell lymphoma that manifests initially in the parotid gland.


name: Recurrent Childhood Non-Hodgkin Lymphoma

description: The reemergence of non-Hodgkin lymphoma in childhood after a period of remission.


name: Refractory Central Nervous System Non-Hodgkin Lymphoma

description: A central nervous system non-Hodgkin lymphoma which does not respond to treatment.


Stage II Burkitt Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Childhood Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: Peripheral T-cell lymphoma, not otherwise specified, that occurs during childhood.


name: Stage II Childhood Anaplastic Large Cell Lymphoma


Head and Neck Burkitt Lymphoma

description: A Burkitt lymphoma that arises from the head and neck region. In patients with endemic Burkitt lymphoma, the jaws and other facial bones are usually affected. In patients with sporadic Burkitt lymphoma, the gingiva, orbit, and Waldeyer ring are usually affected. In patients with immunodeficiency-related Burkitt lymphoma, the lymph nodes are usually affected.


name: Refractory Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

description: Primary vitreoretinal diffuse large B-cell lymphoma that does not respond to treatment.


name: Refractory Hepatosplenic T-Cell Lymphoma

description: Hepatosplenic T-cell lymphoma that is resistant to treatment.


name: HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: A large B-cell lymphoma characterized by the presence of a diffuse proliferation of large, atypical HHV8-positive neoplastic lymphocytes. It usually arises in association with HHV8-positive multicentric Castleman disease.


name: Transformed Small Lymphocytic Lymphoma to Hodgkin Lymphoma

description: Histologic transformation of small lymphocytic lymphoma to Hodgkin lymphoma.


Childhood Burkitt Lymphoma

description: A Burkitt lymphoma occurring in children.


name: Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Burkitt Lymphoma by Ann Arbor Stage

description: An anatomic stage for Burkitt lymphoma based on the Ann Arbor classification criteria.


name: Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

description: The reemergence of primary cutaneous diffuse large B-cell lymphoma, leg type after a period of remission.


name: Breast implant-associated anaplastic large cell lymphoma

description: A rare anaplastic large cell lymphoma that develops in individuals with breast implants. It usually presents as an accumulation of seroma fluid between the implant and the surrounding fibrous capsule. The median interval from the time of the implant to the development of lymphoma is approximately 10 years.


Colorectal Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the colon or rectum.  The majority are B-cell non-Hodgkin lymphomas.


Esophageal Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus.  Dysphagia may be the presenting symptom.  The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue.


name: Childhood Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

description: An extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that occurs during childhood.


name: Extranodal marginal zone B-cell lymphoma (MALT type) recurrent

description: The reemergence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue after a period of remission.


Intestinal Follicular Lymphoma

description: A follicular lymphoma arising from the intestine.  The majority of cases occur in the small intestine, particularly the duodenum.  Usually the patients have localized disease and a favorable clinical outcome.


name: Burkitt Lymphoma with Plasmacytoid Differentiation

description: Burkitt lymphoma characterized by the presence of malignant cells with eccentric basophilic cytoplasm. The nucleoli of these cells are often single and central. This morphologic variant of Burkitt lymphoma is more often seen in patients with immunodeficiency.


adult T-cell leukemia/lymphoma

description: A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1), adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa.


Angiocentric lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: non-Hodgkin's lymphoma of lacrimal gland

description: A non-Hodgkin lymphoma that arises from the lacrimal gland. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma.


Burkitt's lymphoma of breast

description: A Burkitt lymphoma that arises from the breast.  It usually affects pregnant or lactating women and presents with bilateral breast involvement and breast swelling.


name: B-cell small lymphocytic lymphoma refractory

description: B-cell small lymphocytic lymphoma that is resistant to treatment.


name: Ann Arbor Stage III Mature T- and NK-Cell Lymphoma


AIDS-Related Anal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma arising from the anus and occurring in HIV-positive patients.  Homosexual HIV-positive men have an increased risk of developing anal non-Hodgkin lymphoma in comparison to the general male population.  The majority of the cases are large cell lymphomas of B-cell phenotype.


name: Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

description: T-cell/histiocyte-rich large B-cell lymphoma that is resistant to treatment.


Prostate Small Lymphocytic Lymphoma

description: A rare small lymphocytic lymphoma that arises from the prostate gland.


Recurrent Childhood Burkitt Lymphoma

description: The reemergence of Burkitt lymphoma in childhood after a period of remission.


name: Nasal Cavity Extranodal NK/T-Cell Lymphoma

description: An extranodal NK/T-cell lymphoma that arises from the nasal cavity.


Pyothorax-Associated Lymphoma

description: An aggressive diffuse large B-cell lymphoma arising in the pleural cavity of patients with a history of long standing pyothorax.  Patients present with chest and back pain, fever, productive cough, dyspnea, and hemoptysis.


name: Ann Arbor Stage I Grade 1 Follicular Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Aggressive Non-Hodgkin Lymphoma

description: An aggressive non-Hodgkin lymphoma that has recurred after a period of remission.


name: thyroid gland mucosa-associated lymphoid tissue lymphoma

description: An extranodal marginal zone B-cell lymphoma arising from mucosa-associated lymphoid tissue in the thyroid gland. The vast majority of cases are associated with chronic lymphocytic thyroiditis.


non-Hodgkin's lymphoma of nasal cavity

description: A primary non-Hodgkin lymphoma that affects the nasal cavity and the bulk of the tumor is in this anatomic area.  The majority of the cases are nasal type extranodal NK/T-cell lymphomas and diffuse large B-cell lymphomas.


Adult T-cell lymphoma/leukemia stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Primary Choroidal Non-Hodgkin Lymphoma

description: An indolent, low-grade B-cell non-Hodgkin lymphoma that arises from the choroid. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Lymphoid follicles with germinal centers may be present. In the past these tumors were termed 'reactive lymphoid hyperplasia'. Now they are considered low-grade B-cell lymphomas, most commonly extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


name: Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

description: The reemergence of T-cell/histiocyte-rich large B-cell lymphoma after a period of remission.


name: Stage II Childhood Non-Hodgkin Lymphoma by Toronto Guidelines v2

description: A single tumor (extranodal) with regional node involvement or two or more nodal areas on the same side (either above or below) of the diaphragm or two or more single (extranodal) tumors, with or without regional node involvement, on the same side (either above or below) of the diaphragm or a completely resected primary gastrointestinal tract tumor with or without involvement of associated mesenteric nodes only. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Secondary Central Nervous System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


name: Intestinal T-Cell Lymphoma, Not Otherwise Specified

description: A T-cell lymphoma arising in the intestines, or sometimes other sites in the gastrointestinal tract, that does not conform to either classic enteropathy-associated T-cell lymphoma or monomorphic epitheliotropic intestinal T-cell lymphoma. (WHO 2017)


name: Ann Arbor Stage II Mature T- and NK-Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


name: Primary Cutaneous Peripheral T-Cell Lymphoma, Not Otherwise Specified

description: An exceedingly rare peripheral T-cell lymphoma that arises from the skin and does not meet the criteria that define the other well characterized primary cutaneous peripheral T-cell lymphomas, i.e., it is a diagnosis of exclusion.


name: Primary Cerebral Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises in the cerebrum.


name: diffuse large B-cell lymphoma activated B-cell type

description: A diffuse large B-cell lymphoma that is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes.


Marginal zone lymphoma refractory

description: Marginal zone lymphoma which does not respond to treatment.


Cerebral Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises in the cerebral hemispheres as a primary lesion.


name: Ann Arbor Stage II Contiguous Adult Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: primary cutaneous gamma-delta t-cell lymphoma

description: A primary cutaneous T-cell non-Hodgkin lymphoma that is characterized by the clonal cutaneous proliferation of activated mature gamma-delta T cells with a cytotoxic phenotype.


primary effusion lymphoma

description: Primary effusion lymphoma (PEL) is a large B-cell lymphoma located in the body cavities, characterized by pleural, peritoneal, and pericardial fluid lymphomatous effusions and that is always associated with human herpes virus-8 (HHV-8).


Adult Anaplastic Large Cell Lymphoma

description: An anaplastic large cell lymphoma occurring in adults.


Refractory Primary Effusion Lymphoma

description: Primary effusion lymphoma that is resistant to treatment.


name: Helicobacter Pylori-Related Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma that is caused by Helicobacter Pylori.


Refractory Grade 3 Follicular Lymphoma

description: Grade 3 follicular lymphoma that is resistant to treatment.


Early Unfavorable Non-Hodgkin Lymphoma

description: A clinical stage I or II non-Hodgkin lymphoma with at least one of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Thyroid Non-Hodgkin's Lymphoma

description: A non-Hodgkin lymphoma primarily involving the thyroid gland.  The vast majority of cases are either diffuse large B-cell lymphomas or extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue. Hashimoto (chronic lymphocytic) thyroiditis is almost always present.


Grade 2 Cutaneous Follicular Lymphoma

description: A cutaneous lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field.


name: Refractory HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: HHV8-positive diffuse large B-cell lymphoma, not otherwise specified that is resistant to treatment.


name: Refractory Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

description: Diffuse large B-cell lymphoma associated with chronic inflammation that is resistant to treatment.


name: Ann Arbor Stage III Grade 1 Follicular Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Fibrin-Associated Diffuse Large B-Cell Lymphoma

description: An unusual form of diffuse large B-cell lymphoma. It is not mass-forming and does not directly produce symptoms, but it is discovered incidentally on histological examination of surgical pathology specimens, excised for various pathologies other than lymphoma. The specimens typically contain fibrinous materials. Single and small aggregates of large lymphoma cells are found in only small foci within the fibrinous or amorphous material. EBV is positive, with type III latency. The clinical outcome is highly favorable, even with surgical excision alone. (WHO 2017)


Mycosis fungoides recurrent

description: The reemergence of mycosis fungoides after a period of remission.


name: Transformed B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of a B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


name: Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype

description: A are variant of anaplastic large cell lymphoma. It is characterized by presence of large spindle shaped cells resembling a soft tissue sarcoma.


name: Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage IIB includes: T3, N0-2, M0, B0,1. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


Childhood B Lymphoblastic Lymphoma

description: A B-lymphoblastic lymphoma that occurs during childhood.


Head and Neck Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that affects the head and neck region. It usually arises from the ocular adnexa, salivary glands, larynx, and thyroid gland.


name: Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8

description: Stage III includes: (T4, N0-2, M0, B0,1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 8th ed.)


name: Primary mediastinal large B-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Colon Non-Hodgkin Lymphoma

description: An extranodal non-Hodgkin lymphoma that arises from the colon.  The majority are B-cell non-Hodgkin lymphomas.


name: Ann Arbor Stage II Contiguous Adult Burkitt Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Angioimmunoblastic T-cell lymphoma recurrent

description: The reemergence of follicular helper T-cell lymphoma, angioimmunoblastic-type after a period of remission


name: Thymic Mucosa-Associated Lymphoid Tissue Lymphoma

description: A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that affects the thymus.  It is characterized by the presence of centrocyte-like or monocytoid lymphocytes that surround reactive lymphoid follicles.  There is infiltration of the thymic epithelium by lymphocytes and formation of lymphoepithelial lesions.  It is associated with the presence of autoimmune disease, most frequently Sjogren syndrome. Patients are usually asymptomatic and the tumor is detected incidentally as a mediastinal mass on chest x-ray.  A minority of patients present with dyspnea, hemoptysis, and chest pain.  The prognosis is excellent.


name: Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

description: The reemergence of primary vitreoretinal diffuse large B-cell lymphoma after a period of remission.


name: mature T-cell and NK-cell non-Hodgkin lymphoma

description: This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma.


name: non-Hodgkin's lymphoma of small intestine

description: A B-cell or T-cell non-Hodgkin lymphoma that arises from the small intestine.  Representative examples of B-cell non-Hodgkin lymphoma include diffuse large B-cell lymphoma, MALT lymphoma, alpha heavy chain disease/immunoproliferative small intestinal disease, Burkitt lymphoma, follicular lymphoma, and mantle cell lymphoma.  The T-cell non-Hodgkin lymphomas are the enteropathy-associated T-cell lymphoma and the monomorphic CD56 positive intestinal T-cell lymphoma.


name: Childhood Grade III Lymphomatoid Granulomatosis

description: Grade III lymphomatoid granulomatosis that occurs during childhood.


Stage II Childhood Burkitt Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Primary Cutaneous Plasmablastic Lymphoma

description: Plasmablastic lymphoma that arises from the skin.


name: Primary Bone Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the bone, without lymph node or other extranodal involvement.


name: Refractory Mature B-Cell Non-Hodgkin Lymphoma

description: Mature B-cell non-Hodgkin lymphoma that does not respond to treatment.


Angiocentric lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Centroblastic Lymphoma by Ann Arbor Stage

description: An anatomic stage for centroblastic lymphoma based on the Ann Arbor classification criteria.


B Lymphoblastic Lymphoma

description: An uncommon type of lymphoma.  It constitutes approximately 10% of cases of lymphoblastic lymphoma.  Approximately 75% of cases reported in a literature review involved patients who were less than 18 years of age.  The most commonly affected sites are the skin, bone, soft tissue, and lymph nodes.  It has a high remission rate with a median survival of approximately 60 months.  (WHO, 2001)


name: Central Nervous System B-Cell Non-Hodgkin Lymphoma

description: A B-cell non-Hodgkin lymphoma that arises from the brain, meninges, or spinal cord.


name: Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

description: The reemergence of diffuse large B-cell lymphoma germinal center B-cell type after a period of remission.


name: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Involving the Digestive System

description: An extranodal low-grade B-cell non-Hodgkin lymphoma arising in mucosal or glandular tissues of the digestive system. It recapitulates the cytoarchitectural features of mucosa-associated lymphoid tissue (MALT). It is composed of small lymphoid cells, often including marginal zone cells. (WHO 2019)


name: Precursor B-lymphoblastic lymphoma recurrent

description: The reemergence of B-lymphoblastic lymphoma after a period of remission.


name: Digestive System Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma that arises from the digestive system.


name: Nodal Marginal Zone Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodal marginal zone lymphoma based on the Ann Arbor classification criteria.


name: St. Jude Stage II Childhood Non-Hodgkin Lymphoma AJCC v8

description: Stage II: A single tumor (extranodal) with regional node involvement. Two or more nodal areas on the same side of the diaphragm. Two single (extranodal) tumors with or without regional node involvement on the same side of the diaphragm. A primary gastrointestinal tract tumor, usually in the ileocecal area, with or without involvement of associated mesenteric nodes only. (from AJCC 8th Ed.)


name: Marginal Zone Lymphoma by Ann Arbor Stage

description: An anatomic stage for marginal zone lymphoma based on the Ann Arbor classification criteria.


name: Mycosis fungoides/Sezary syndrome refractory

description: Mycosis fungoides and Sezary syndrome that is resistant to treatment.


name: AIDS-Related Burkitt Lymphoma with Plasmacytoid Differentiation

description: A Burkitt lymphoma with plasmacytoid differentiation occurring in HIV-positive patients.


name: High Grade B-Cell Lymphoma with Blastoid Morphologic Features

description: A high-grade B-cell lymphoma characterized by the presence of medium-size neoplastic lymphocytes with a scant amount of cytoplasm and inconspicuous nucleoli, resembling lymphoblasts.


name: Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

description: The reemergence of primary cutaneous T-cell non-Hodgkin lymphoma after a period of remission.


name: Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

description: Diffuse large B-cell lymphoma germinal center B-cell type that is resistant to treatment.


Intestinal T-cell lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Burkitt-like lymphoma with 11q aberration

description: A molecularly distinct large B-cell lymphoma reminiscent of Burkitt lymphoma. It is characterized by the absence of MYC translocation and the presence of chromosome 11q aberrations.


Adult Non-Hodgkin Lymphoma

description: Non-Hodgkin lymphoma occurring in adults.


name: Lymphohistiocytic Variant Anaplastic Large Cell Lymphoma

description: A histologic variant of anaplastic large cell lymphoma characterized by the presence of a large number of histiocytes admixed with the anaplastic lymphoma cells.


Thyroid Immunoblastic Lymphoma

description: A diffuse large B-cell lymphoma variant, primarily involving the thyroid gland.  It is composed predominantly of immunoblasts.


Head and Neck Plasmablastic Lymphoma

description: A plasmablastic lymphoma that arises from the head and neck region. The most frequently affected site is the oral cavity.


name: Recurrent Transformed T-cell Non-Hodgkin Lymphoma

description: The reemergence of T-cell non-Hodgkin lymphoma transformed after a period of remission.


description: Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly is a rare form of diffuse large B-cell lymphoma occurring most commonly in patients over the age of 50 (usually between 70-75 years of age), without overt immunodeficiency, and presenting with nodal and extranodal involvement (in sites such as the stomach, lung, skin and pancreas) and B symptoms (fever, night sweats, weight loss). The tumor is characterized by an aggressive course and a short survival rate.


name: Childhood Anaplastic Large Cell Lymphoma, ALK-Positive

description: An anaplastic large cell lymphoma, ALK-positive that occurs during childhood.


Lymphoma, Large-Cell, Follicular

description: A follicular lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


name: Recurrent High Grade B-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of high-grade B-cell lymphoma, not otherwise specified, after a period of remission.


name: Adult T-cell lymphoma/leukemia refractory

description: Adult T-cell leukemia/lymphoma that is resistant to treatment.


name: Refractory High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements

description: High-grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements that is resistant to treatment.


name: B-cell small lymphocytic lymphoma recurrent

description: The reemergence of small lymphocytic lymphoma after a period of remission.


Extracavitary Primary Effusion Lymphoma

description: A rare HHV8-positive B-cell lymphoma indistinguishable from primary effusion lymphoma presenting as solid tumor mass. (WHO 2017)


name: Stage II Indolent Adult Non-Hodgkin Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Stage IV Adult Immunoblastic Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Aggressive Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma with an aggressive clinical course.  Representative examples include Burkitt lymphoma, mantle cell lymphoma, and angioimmunoblastic T-cell lymphoma.


name: Parotid Gland Mucosa-Associated Lymphoid Tissue Lymphoma

description: A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue arising from the parotid gland. It is the most common type of non-Hodgkin lymphoma in the parotid gland and is often associated with Sjogren syndrome. The prognosis is favorable.


follicular lymphoma of salivary gland

description: A follicular lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland.


ST2 Diffuse Large B-Cell Lymphoma

description: A genetic subtype of diffuse large B-cell lymphoma characterized by SGK1 and TET2 gene mutations.


name: non-Hodgkin's lymphoma of salivary gland

description: A non-Hodgkin lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. Mucosa-associated lymphoid tissue lymphoma is the most common primary salivary gland non-Hodgkin lymphoma.


name: Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of EBV-positive diffuse large B-cell lymphoma, not otherwise specified after a period of remission.


name: Ann Arbor Stage II Grade 1 Non-Contiguous Follicular Lymphoma


name: Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IIA includes: T1-2, N1-2, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Non-Hodgkin's lymphoma refractory

description: A non-Hodgkin lymphoma which does not respond to treatment.


follicular lymphoma of lacrimal gland

description: A follicular lymphoma that arises from the lacrimal gland.


name: Stage IA Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IA includes: T1, N0, M0, B0-1.  T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


Sinonasal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the sinonasal tract.


name: Ann Arbor Stage II Adult Non-Contiguous Immunoblastic Lymphoma


Angiocentric lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

description: An immunoblastic lymphoma that arises in a patient with a history of organ transplantation.


name: Lugano Classification Stage III Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


name: Recurrent Indolent T-Cell Non-Hodgkin Lymphoma

description: The reemergence of indolent T-cell non-Hodgkin lymphoma after a period of remission.


name: Stage III Anaplastic Large Cell Lymphoma

description: Ann Arbor Classification. Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Stage II Adult Non-Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3).


name: Nodal marginal zone B-cell lymphoma refractory

description: Nodal marginal zone B-cell lymphoma resistant to treatment.


name: Primary Nodal EBV-Positive T-Cell/NK-Cell Lymphoma

description: An EBV-positive T-cell/NK-cell lymphoma that arises from the lymph nodes. It is characterized by a monomorphic pattern of infiltration and abscence of the angiodestruction and necrosis seen in extranodal NK/T-cell lymphomas. These lymphomas are more common in elderly patient, or in the setting of immune deficiency. (WHO 2017)


name: Diffuse malignant lymphoma - centroblastic

description: A B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a subtype of diffuse large B-cell non-Hodgkin lymphoma.


name: Recurrent Indolent B-Cell Non-Hodgkin Lymphoma

description: The reemergence of indolent B-cell non-Hodgkin lymphoma after a period of remission.


name: B-cell small lymphocytic lymphoma stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

description: The reemergence of mature T-cell and NK-cell non-Hodgkin lymphoma after a period of remission.


name: Refractory Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma

description: Diffuse large B-cell lymphoma that resulted from the transformation of marginal zone lymphoma and is resistant to treatment.


name: Angioimmunoblastic T-cell lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Early Favorable Non-Hodgkin Lymphoma

description: A clinical stage I or II non-Hodgkin lymphoma without any of the following risk factors: large mediastinal mass, extranodal spread, elevated erythrocyte sedimentation rate, involvement of at least three lymph node areas, and B symptoms.


Mycosis fungoides stage II

description: Stage II includes: IIA (T1-2, N1-2, M0, B0-1); IIB (T3, N0-2, M0, B0-1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface.  May further stratify into T1a (patch only) vs. T1b (plaque +/- patch).  T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  T3: One or more tumors (equal or greater than 1 cm diameter).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2.  N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Ann Arbor Stage I Subdiaphragmatic Nodular Lymphocyte Predominant B-Cell Lymphoma


Refractory Grade 2 Follicular Lymphoma

description: Grade 2 follicular lymphoma that is resistant to treatment.


name: Leukemic Phase of Non-Hodgkin's Lymphoma

description: A usually terminal event in the clinical course of lymphomas.  The term indicates the presence of atypical, clonal (malignant) lymphocytes (lymphoma cells) in the peripheral blood.


name: Refractory Aggressive Non-Hodgkin Lymphoma

description: An aggressive non-Hodgkin lymphoma that is resistant to treatment.


name: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes

description: Molecular subtyping of diffuse large B-cell lymphomas (DLBCL) based on structural genomic abnormalities and gene expression data obtained from biopsy samples. The molecular analysis revealed four subtypes of DLBCL (MCD, BN2, N1, and EZB) which have distinct genotypic, epigenetic, and clinical characteristics. (NEJM 2018; 378: 1396-407)


name: Lugano Classification Limited Stage Adult Non-Hodgkin Lymphoma AJCC v8

description: Limited stage adult non-Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Adult T-cell lymphoma/leukemia stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


Splenic Small Lymphocytic Lymphoma

description: Small lymphocytic lymphoma occurring in the spleen.


name: diffuse large B-cell lymphoma of the central nervous system

description: A diffuse large B-cell lymphoma arising from the central nervous system.


Follicular T-cell lymphoma

description: Follicular helper T-cell lymphoma with a predominantly follicular growth pattern.


Pharyngeal Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the pharynx.


Splenic Lymphoplasmacytic Lymphoma

description: A lymphoplasmacytic lymphoma  occurring in the spleen.


name: Refractory Breast Implant-Associated Anaplastic Large Cell Lymphoma

description: Breast implant-associated anaplastic large cell lymphoma that is resistant to treatment.


non-Hodgkin's lymphoma of liver

description: A rare non-Hodgkin lymphoma that arises from the liver and the bulk of the tumor is located in the liver.  The most frequent types of non-Hodgkin lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma.


Mantle cell lymphoma refractory

description: Mantle cell lymphoma resistant to treatment.


AIDS-Related Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that develops in a patient with AIDS.


name: Primary Mediastinal Large B-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for primary mediastinal large B-cell lymphoma based on the Ann Arbor classification criteria.


Stage II Diffuse Large B-Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Adult Diffuse Large B-Cell Lymphoma

description: A diffuse large B-cell lymphoma occurring in adults.


Classic Follicular Lymphoma

description: A term that refers to follicular lymphoma grade 1, 2, and 3A.


name: Childhood Large B-Cell Lymphoma with IRF4 Rearrangement

description: A large B-cell lymphoma with IRF4 rearrangement that occurs during childhood.


ALK-positive large B-cell lymphoma

description: Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.


name: Lugano Classification Stage IE Adult Non-Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement. (from AJCC 8th Ed.)


name: peripheral T-cell lymphoma, not otherwise specified

description: Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas. This category includes the following variants: lymphoepithelioid cell variant (Lennert's lymphoma), follicular variant, and T-zone variant.


Recurrent Grade 1 Follicular Lymphoma

description: The reemergence of grade 1 follicular lymphoma after a period of remission.


name: Stage I Childhood Lymphoblastic Lymphoma

description: Stage I: A single tumor or nodal area is involved, excluding the abdomen and mediastinum (from PDQ).


name: Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v7

description: Stage IB includes: T2, N0, M0, B0-1. T2: Patches, papules, or plaques covering 10% or more of the skin surface.  May further stratify into T2a (patch only) vs. T2b (plaque +/- patch).  N0: No clinically abnormal peripheral lymph nodes; biopsy not required.  M0: No visceral organ involvement.  B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).  B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.  (AJCC 7th ed.)


name: Anaplastic Large Cell Lymphoma, Signet Ring-Like Subtype

description: An anaplastic large cell lymphoma, characterized by lymphoid cells with signet ring nuclei.


name: Extranodal marginal zone B-cell lymphoma (MALT type) stage III

description: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue presenting as stage III disease.


name: Recurrent Central Nervous System Non-Hodgkin Lymphoma

description: The reemergence of central nervous system non-Hodgkin lymphoma after a period of remission.


description: ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) is a type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK).


name: Mycosis fungoides/Sezary syndrome recurrent

description: The reemergence of mycosis fungoides/Sezary syndrome after a period of remission.


Recurrent Adult Lymphoblastic Lymphoma

description: The reemergence of adult lymphoblastic lymphoma after a period of remission.


name: Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of an indolent B-cell non-Hodgkin lymphoma to an aggressive diffuse large B-cell lymphoma.


name: Adult Primary Cutaneous Anaplastic Large Cell Lymphoma

description: Primary cutaneous anaplastic large cell lymphoma that occurs in adults.


Aggressive T-Cell Non-Hodgkin Lymphoma

description: A T-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes T lymphoblastic lymphoma, anaplastic large cell lymphoma, ALK-negative, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, intestinal T-cell lymphoma, nasal type extranodal NK/T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified, and subtypes of primary cutaneous T-cell non-Hodgkin lymphoma.


name: Follicular Lymphoma with Unusual Cytological Features

description: An uncommon morphologic variant of follicular lymphoma characterized by the presence of predominantly medium-sized neoplastic lymphocytes with blastoid features or large neoplastic lymphocytes with cleaved nuclei.


name: Recurrent Systemic Anaplastic Large Cell Lymphoma, ALK-Positive

description: The reemergence of systemic anaplastic large cell lymphoma, ALK-positive after a period of remission.


name: Recurrent Mature B-Cell Non-Hodgkin Lymphoma

description: The reemergence of mature B-cell non-Hodgkin lymphoma after a period of remission.


name: Lacrimal System Mucosa-Associated Lymphoid Tissue Lymphoma

description: A mucosa-associated lymphoid tissue lymphoma that arises from the lacrimal gland or the lacrimal drainage system.


name: Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

description: Primary cutaneous diffuse large B-cell lymphoma, leg type that is resistant to treatment.


Grade 3 Cutaneous Follicular Lymphoma

description: A cutaneous lymphoma which contains more than 15 centroblasts per 40X high-power microscopic field.


Gastric Burkitt Lymphoma

description: An extranodal Burkitt lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Recurrent Non-Hodgkin Lymphoma

description: The reemergence of non-Hodgkin lymphoma after a period of remission.


name: Small Lymphocytic Lymphoma by Ann Arbor Stage

description: An anatomic stage for small lymphocytic lymphoma based on the Ann Arbor classification criteria.


name: High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

description: High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and/or BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.


name: Diffuse large B-cell lymphoma associated with chronic inflammation

description: A diffuse large B-cell lymphoma arising in body cavities or narrow spaces of long standing chronic inflammation.  The classic example is the pyothorax-associated lymphoma that arises in the pleural cavity of patients with a history of long standing pyothorax.


name: Primary mediastinal large B-cell lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


gastric diffuse large B-cell lymphoma

description: An extranodal diffuse large B-cell lymphoma that arises from the stomach with the bulk of the mass located in the stomach.


Non-Hodgkin Lymphoma During Pregnancy

description: Non-Hodgkin lymphoma that occurs during pregnancy.


Recurrent Primary Effusion Lymphoma

description: The reemergence of primary effusion lymphoma after a period of remission.


name: Enteropathy-Associated T-Cell Lymphoma by Ann Arbor Stage

description: An anatomic stage for enteropathy-associated T-cell lymphoma based on the Ann Arbor classification criteria.


name: Childhood Non-Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for childhood non-Hodgkin lymphoma based on the Ann Arbor classification criteria.


Tonsillar Mantle Cell Lymphoma

description: A rare mantle cell lymphoma that affects the tonsil and the bulk of the tumor is in this anatomic area.


name: DUSP22-R Anaplastic Large Cell Lymphoma, ALK-Negative

description: A genetic subtype of systemic anaplastic large cell lymphoma, ALK-negative characterized by rearrangement of DUSP22 gene. It tends to have a favorable prognosis.


name: Ann Arbor Stage IV Grade 3 Follicular Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

description: The reemergence of monomorphic epitheliotropic intestinal T-cell lymphoma after a period of remission.


name: Small Intestinal Atypical Burkitt/Burkitt-Like Lymphoma

description: A morphologic variant of Burkitt lymphoma that arises from the small intestine.  It is characterized by marked nuclear pleomorphism, abundant apoptotic debris, and the presence of tangible body macrophages.


Transformed Non-Hodgkin Lymphoma

description: Histologic transformation of a usually indolent non-Hodgkin lymphoma to an aggressive non-Hodgkin lymphoma.


Prostate Follicular Lymphoma

description: A rare follicular lymphoma that arises from the prostate gland.


Burkitt's lymphoma of kidney

description: A rare Burkitt lymphoma arising from the kidney.


name: Adult T-cell lymphoma/leukemia recurrent

description: The reemergence of adult T-cell leukemia/lymphoma after a period of remission


name: Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

description: Small lymphocytic lymphoma characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Unfavorable Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma with unfavorable prognosis.


name: Nodal marginal zone B-cell lymphoma stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Nodal marginal zone B-cell lymphoma stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Recurrent Transformed B-Cell Non-Hodgkin Lymphoma

description: The reemergence of B-cell non-Hodgkin lymphoma transformed after a period of remission.


Refractory Grade 3a Follicular Lymphoma

description: Grade 3a follicular lymphoma that is resistant to treatment.


name: Refractory Nodular Lymphocyte Predominant B-Cell Lymphoma

description: Nodular lymphocyte predominant B-cell lymphoma that is resistant to treatment.


Primary Iris Non-Hodgkin Lymphoma

description: An extremely rare low-grade B-cell non-Hodgkin lymphoma that arises from the iris. It is characterized by the presence of a diffuse infiltrate of small, round lymphocytes. Most cases represent extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.


follicular lymphoma of lung

description: An exceedingly rare follicular lymphoma that arises in and is confined to the lung at the time of diagnosis.


breast diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that arises from the breast. It is the most common type of primary breast lymphoma.


name: Lymphoplasmacytic Lymphoma by Ann Arbor Stage

description: An anatomic stage for lymphoplasmacytic lymphoma based on the Ann Arbor classification criteria.


name: Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

description: Primary diffuse large B-cell lymphoma of the central nervous system that does not respond to treatment.


name: Lacrimal Drainage System Non-Hodgkin Lymphoma

description: A non-Hodgkin lymphoma that arises from the lacrimal sac. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


name: Diffuse large B-cell lymphoma refractory

description: Diffuse large B-cell lymphoma that is resistant to treatment.


indolent B-cell non-Hodgkin lymphoma

description: A B-cell non-Hodgkin lymphoma with an indolent clinical course. Representative examples include grade 1 and grade 2 follicular lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma.


name: Recurrent HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

description: The reemergence of HHV8-positive diffuse large B-cell lymphoma, not otherwise specified, after a period of remission.


Mycosis Fungoides by AJCC v7 Stage

description: A term that refers to the staging of mycosis fungoides, following the rules of the TNM AJCC v7 classification system.


name: Cardiac Fibrin-Associated Diffuse Large B-Cell Lymphoma

description: A rare fibrin-associated diffuse large B-cell lymphoma that affects the heart.


name: Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma

description: A nodular lymphocyte predominant B-cell lymphoma occurring in children.


Recurrent Grade 3 Follicular Lymphoma

description: The reemergence of grade 3 follicular lymphoma after a period of remission.


name: Central Nervous System Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

description: A primary central nervous system non-Hodgkin lymphoma derived from mature or post-thymic T-cells or NK-cells.


name: Recurrent Primary Cutaneous Gamma-Delta T-Cell Lymphoma

description: The reemergence of primary cutaneous gamma-delta T-cell lymphoma after a period of remission


name: Transformed Waldenstrom Macroglobulinemia to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of Waldenstrom macroglobulinemia to an aggressive diffuse large B-cell lymphoma.


name: diffuse large B-cell lymphoma germinal center B-cell type

description: A diffuse large B-cell lymphoma that is characterized by the expression of CD10, BCL-6, A-myb, and LMO2 genes, BCL-2 translocation, and c-REL amplification.