Bladder Cancer by AJCC v8 Stage

description: A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas arising in the bladder. The typical carcinoma of the bladder is urothelial carcinoma. These carcinomas may include other histologic elements, including adenocarcinoma, squamous cell carcinoma, and small cell neuroendocrine carcinoma, but should be classified as urothelial unless the cancer is composed entirely of the alternative histology. All histologic cell types that are derived primarily from the urinary bladder epithelium should follow this staging system. It does not apply to prostatic urothelial carcinomas (are staged according to the classification for urethra), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Bronchial Fistula

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An abnormal communication between the bronchus and another organ or anatomic site.


name: Advanced Gastric Large Cell Neuroendocrine Carcinoma

description: A gastric large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Type IV Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the right and left pulmonary arteries drain into different sites.


name: Refractory Endometrial Mucinous Adenocarcinoma

description: Endometrial mucinous adenocarcinoma that is resistant to treatment.


Adenocarcinoma of the prostate stage I

description: Stage I includes: (T1a-c, N0, M0, PSA less than 10, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 10, Gleason equal or less than 6); (T1-2a, N0, M0, PSA X, Gleason X).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less. cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason X: Gleason score cannot be processed.  (AJCC 7th ed.)


Stage IA Bone Cancer AJCC v7

description: Stage IA includes: T1, N0, M0, G1, G2, GX.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


lymphomatoid papulosis, type A

description: A variant of lymphomatoid papulosis characterized by the presence of scattered anaplastic large lymphocytes, often resembling Reed-Sternberg cells, admixed with acute and chronic inflammatory cells.


Intra-Abdominal Paraganglioma

description: An extra-adrenal paraganglioma arising from the abdominal cavity.


name: Pancreatic Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a pancreatic neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system. This staging system applies to well-differentiated neuroendocrine tumors arising in the pancreas. Carcinomas of the pancreas, including high-grade (grade 3), poorly differentiated neuroendocrine carcinomas are not staged using this staging system. (from AJCC 8th Ed.)


name: Adult Dysembryoplastic Neuroepithelial Tumor

description: A dysembryoplastic neuroepithelial tumor that occurs during adulthood.


Stage III Gallbladder Cancer AJCC v7

description: Stage III includes: IIIA (T3, N0, M0); IIIB (T1-3, N1, M0). T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  T1: Tumor invades lamina propria or muscular layer.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver. N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Non-T Non-B CALLA Negative Adult Acute Lymphoblastic Leukemia

description: Non-T non-B, CALLA negative acute lymphoblastic leukemia that occurs during adulthood.


name: Metastatic Human Papillomavirus-Related Malignant Neoplasm

description: A malignant neoplasm that is associated with human papillomavirus infection and has spread from its original site of growth to another anatomic site.


Adult Ependymal Tumor

description: An ependymal tumor of the central nervous system occurring in adults.


Impatent structure

description: A congenital anatomic defect characterised by the absence of a normally present opening in an organ or tissue.


Stage IIIA Appendix Carcinoma AJCC v7

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N1: Metastasis in 1-3 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


P3 Hydronephrosis

description: Postnatal Hydronephrosis with the following clinical findings: 1) calyceal dilation and the ureter are the same as those in UTD P2, 2) the renal parenchymal is thinned, has increased echogenicity and/or has decreased corticomedullary differentiation, or 3) the bladder is abnormal (wall thickening, ureterocele, posterior urethral dilation). Cases in which there are parenchymal abnormalities but the APRPD is less than 15 mm, are classified as UTD P3. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)


name: Primary Intraosseous Squamous Cell Carcinoma-Solid Type

description: A non-keratinizing or keratinizing squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, infiltration of the marrow spaces, and osseous resorption.


Tumor associated fever

description: Non-infectious pyrexia secondary to malignancy; it may be attributable to cytokines elaborated by neoplasms, and is a diagnosis of exclusion.


Ureter Urothelial Carcinoma, High Grade

description: Ureter urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features.


name: Stage IIIC2 Uterine Corpus Cancer AJCC v8

description: Stage IIIC2 includes: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


Stage II Childhood Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


name: Familial Catecholamine-Induced QT Prolongation

description: A familial phenotype characterized by a normal QT interval at rest, but major QT lengthening during catecholergic stimulation.


name: Testicular Sex Cord-Gonadal Stromal Tumor, Incompletely Differentiated

description: A sex cord-stromal tumor of the testis in which the neoplastic cells do not show specific differentiation.


name: Refractory Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that is resistant to treatment.


Malignant lymphoma, diffuse

description: An antiquated term referring to non-Hodgkin lymphomas with a diffuse architectural pattern.


name: Retinopathy of Prematurity with Plus Disease

description: A stage of retinopathy of prematurity characterized by the presence of the following in at least two quadrants around the optic nerve: dilation and tortuosity of major retinal vasculature as a result of increased blood flow.


name: Ampulla of Vater Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

description: A rare variant of undifferentiated carcinoma that arises from the ampulla of Vater. It is characterized by the presence of non-neoplastic, histiocytic, osteoclast-like multinucleated giant cells.


name: High-Grade Squamous Intraepithelial Lesions

description: A precancerous neoplastic process characterized by the presence of moderate or severe dysplastic cytological changes which extend to the upper part of the squamous epithelium.  Maturation at the surface of the squamous epithelium may or may not be present.  Representative examples include the high grade esophageal squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar intraepithelial neoplasia.


name: Solar Radiation-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma arising in a skin site exposed to solar radiation.


name: Reactive attachment disorder of infancy or early childhood

description: A condition in which the failure to establish healthy bonds with caregivers in early childhood leads to lifelong impairment of social interactions.


name: Locally Advanced Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Sexually Transmitted Chlamydial Disease

description: A chlamydial infection that was sexually transmitted.


name: Recurrent Malignant Genitourinary System Neoplasm

description: The reemergence of a malignant genitourinary system neoplasm after a period of remission.


Unresectable Gastric Adenocarcinoma

description: A gastric adenocarcinoma that is not amenable to surgical resection.


Enteropathogenic E coli Infection

description: A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 9-12 hours and a duration of 12 days. Symptoms may include persistent severe acute diarrhea.


Biliary Fistula

description: An abnormal communication between the bile ducts and another organ or cavity.


Spindle Cell/Pleomorphic Lipoma

description: A benign lipomatous neoplasm characterized by the presence of an admixture of mature adipose tissue and bland spindle cells.  The pleomorphic variant contains in addition multinucleated giant cells.  It usually arises in the neck and upper trunk in older males.


name: Stage IIIC1 Uterine Corpus Cancer AJCC v7

description: Stage IIIC1 includes: T1-T3, N1, M0.  T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Stage II Skin Cancer

description: Stage II includes: T2, N0, M0.  T2: Tumor size greater than 2 cm in greatest dimension or tumor of any size with two or more high-risk features.  High-risk features for the primary tumor staging are defined as follows: depth/invasion of more than 2 mm thickness; Clark level equal or greater than IV; and perineural invasion.  Anatomic location: primary site ear and primary site non-hair-bearing lip.  Differentiation: poorly differentiated or undifferentiated.  N0: No regional lymph node metastasis.  M0: No clinical or radiographic evidence of distant metastasis.  (AJCC 7th ed.)


Refractory Pseudomyxoma Peritonei

description: Pseudomyxoma peritonei that is resistant to treatment.


Condylomatous carcinoma

description: A squamous cell carcinoma characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


Advanced Glioblastoma

description: Glioblastoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Corn of toe

description: A thickening of the skin due to friction or pressure which results in the formation of a small, painful, raised bump associated with a conical mass pointing down into the dermis.


name: K ATP Channel-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in genes (KNCJ11 and/or ABCC8) encoding either of the 2 proteins (Kir6.2 and/or SUR1) that make up the pancreatic beta cell adenosine triphosphate-sensitive potassium channel, which is crucial for the regulation of glucose-induced insulin secretion.


name: Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIIA includes: (T1, N2, M0, Any G); (T2, N1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Recurrent Malignant Choroid Plexus Neoplasm

description: The reemergence of a malignant choroid plexus neoplasm after a period of remission.


name: Extrahepatic Bile Duct Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the extrahepatic bile duct epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


Regressed germ cell tumor

description: A testicular germ cell tumor that has undergone either partial or complete regression, resulting in the creation of a fibrotic nodule in the testis.


Neuroendocrine Tumor G1

description: A well-differentiated, low-grade epithelial neoplasm with neuroendocrine differentiation. It arises from multiple sites, including the digestive system, lung, and head and neck.


name: AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease

description: Diffuse large B-cell lymphoma arising in HHV8-positive multicentric Castleman disease occurring in HIV-positive patients.


name: Vulvar Squamous Cell Carcinoma with Tumor Giant Cells

description: An aggressive squamous cell carcinoma that arises from the vulva and is characterized by the prominence of malignant giant cells.


Neoplasms, Therapy-Associated

description: The development of a neoplasm in response to medical or surgical treatment, induced by the treatment itself.


Prevertebral Abscess

description: An abscess that develops in the tissues within the prevertebral fascia.


Unresectable Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that is not amenable to surgical resection.


Stage II Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Non-Severe Aplastic Anemia

description: Aplastic anemia that is characterized by bone marrow cellularity less than 30% and does not meet criteria for severe aplastic anemia.


Acquired Bilateral Cataracts

description: Cataracts in both eyes that result from the aging process, an injury, or as a manifestation of a systemic disorder.


Gastric Fistula

description: An abnormal communication between the stomach and another organ or anatomic site.


Diabetes mellitus without complication

description: Diabetes mellitus that does not show any evidence of tissue or organ damage.


name: Stage IA Ampulla of Vater Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Advanced Sarcoma of the Extremity

description: A sarcoma of the soft tissues or bones of the upper or lower extremity that has spread extensively to other anatomic sites or is no longer responding to treatment.


Serous Tubal Intraepithelial Carcinoma

description: A non-invasive serous carcinoma arising from the fallopian tube.


Age-Related Clonal Hematopoiesis

description: The gradual, clonal expansion of hematopoietic stem and progenitor cells carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. It is associated with an increased risk of developing hematologic cancers.


Secondary Cerebral Hodgkin Lymphoma

description: A Hodgkin lymphoma that has spread to the cerebral hemisphere following the initial presentation in another nodal or extranodal site.


Lesion

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part.


Borderline Peritoneal Serous Tumor

description: A serous epithelial tumor that arises from the peritoneum and histologically resembles the serous borderline tumors that arise from the ovary.


name: Pathologic Stage IIC Cutaneous Melanoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Metastatic malignant neoplasm to urethra

description: A malignant neoplasm that has spread to the urethra from another anatomic site.


Broncho-esophageal fistula

description: An abnormal connection between a bronchus and the esophagus.


Inflammatory Hepatocellular Adenoma

description: A hepatocellular adenoma that occurs more often in women.  It is characterized by increased levels of inflammation-associated proteins.  It is usually associated with steatosis and obesity.


Non-Obstructed Megaureter

description: A megaureter in which there is no obstruction at the ureterovesical junction.


name: Refractory Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma that is resistant to treatment.


Stage III Uterine Corpus Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Unresectable Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that is not amenable to surgery.


Urinary System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the urinary system. Representative examples include kidney carcinoma and bladder carcinoma.


Recto-Vesico-Vaginal Fistula

description: An abnormal communication between the rectum, bladder, and vagina.


Broad Ligament Serous Adenofibroma

description: A rare serous adenofibroma arising from the broad ligament.


description: An adenocarcinoma associated with the presence of human papillomavirus infection.


Refractory T-Cell and NK-Cell Neoplasm

description: T-cell and NK-cell neoplasm that is resistant to treatment.


Recurrent Primary Cutaneous Lymphoma

description: The reemergence of primary cutaneous lymphoma after a period of remission.


Asymptomatic Infections

description: Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps.


name: Serum IgM Monoclonal Gammopathy of Less than 30g/L

description: An abnormal laboratory test result indicating that a serum IgM paraprotein concentration is less than 30g/L.


Stage IIB Bone Cancer AJCC v8

description: Stage IIB includes: T2, N0, M0, G2 or G3. T2: Tumor measuring more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Advanced Ocular Melanoma

description: Ocular melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Tectal Glioma

description: A glioma that arises from the tectum mesenchephali.


Monoplegia

description: Paralysis that affects one limb.


Epididymal Squamous Cell Carcinoma

description: An exceedingly rare carcinoma with squamous differentiation arising from the epididymis.


Adipsic Diabetes Insipidus

description: Diabetes insipidus complicated by a deficient or absent thirst response to hyperosmolality, usually as a result of hypothalamic damage or dysfunction.


name: WNT-Activated Deep Penetrating/Plexiform Melanocytoma (Nevus)

description: A benign melanocytic neoplasm composed of spindle and/or epithelioid melanocytes and melanophages. It is caused by the combined activation of the WNT signaling and MAP-kinase pathways. It occurs in the head and neck region, trunk, extremities, and conjunctiva. It presents with well-circumscribed, darkly pigmented papules. The neoplastic melanocytes form wedge-shaped, fascicular, or plexiform patterns. Lesions with a wedge-shaped pattern extend into the deep reticular dermis. In plexiform spindle cell lesions, the neoplastic melanocytes proliferate in the upper dermis. A junctional component is present in the majority of cases. It rarely progresses to melanoma.


Recurrent Schwannoma

description: The reemergence of schwannoma after a period of remission.


Infant Acute Biphenotypic Leukemia

description: An acute biphenotypic leukemia that occurs in infancy.


name: Stage IV Gastric Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor invading the lamina propria or submucosa and is less than or equal to 1 cm in size. T2: Tumor invading the muscularis propria or is greater than 1 cm in size. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading visceral peritoneum (serosa) or other organs or adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Non-IgM Monoclonal Gammopathy of Undetermined Significance

description: Monoclonal gammopathy of undetermined significance defined by the presence in the serum of an IgG, IgA, or (rarely) IgD paraprotein at a concentration of less than 30g/L; clonal bone marrow plasma cells less than 10%; and absence of end-organ damage such as hypercalcemia, renal insufficiency, anemia, bone marrow lesions, and amyloidosis attributable to the plasma cell proliferative disorder. The risk of progression to plasma cell myeloma, light-chain amyloidosis, or a related disorder is 1% per year. (WHO 2017)


name: Metastatic Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Meningeal Lymphoma

description: Involvement of the meninges by Hodgkin or non-Hodgkin lymphoma.


Xerostomia caused by ionizing radiation

description: Dryness of the oral mucosa secondary to radiation therapy.


name: Recurrent Acute Myeloid Leukemia with KMT2A Rearrangement

description: The reemergence of acute myeloid leukemia with KMT2A rearrangement after a period of remission.


Urinary System Paraganglioma

description: An extra-adrenal paraganglioma that arises from the urinary system.


Surgical Wound Infection

description: An infection that occurs at a surgical site within 30 days after an operation.


Refractory Lymphoproliferative Disorder

description: Lymphoproliferative disorder that is resistant to treatment.


Penile Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the penis. Representative examples include phimosis, balanitis, and hypospadias.


name: large cell neuroendocrine carcinoma of appendix

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix.  It is characterized by the presence of malignant large cells.


Childhood Bone Neoplasm

description: A bone neoplasm that occurs during childhood.


Stage IVB Uterine Corpus Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa). (from AJCC 8th Ed.)


Neoplasm of broad ligament

description: A benign, borderline, or malignant neoplasm that affects the broad ligament.


name: Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: Chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.


Stage I Cervical Cancer FIGO 2009

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2009)


Refractory Gliosarcoma

description: A gliosarcoma that is resistant to treatment.


Spinal vascular disorder

description: A disorder that is caused by pathologic changes in the spinal vasculature.


Kidney Neuroendocrine Tumor

description: A well-differentiated neuroendocrine neoplasm arising from the kidney. It is characterized by the presence of uniform cells with stippled chromatin and inconspicuous nucleoli. Mitotic activity is low and tumor necrosis is absent.


Esophageal Schwannoma

description: A slowly growing, benign, usually encapsulated neoplasm arising from the esophagus.  Morphologically, it is composed of neoplastic differentiated Schwann cells.


name: Stage III Gestational Trophoblastic Tumor AJCC v7

description: Stage III includes: (Any T, M1a, Risk factors: unknown); IIIA (Any T, M1a, Risk factors: low risk); IIIB (Any T, M1a, Risk factors: high risk).  M1a: Lung metastasis.  (AJCC 7th ed.)


name: Diffuse Hyperplastic Perilobar Nephroblastomatosis


Posthemorrhagic hydrocephalus

description: An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a later sequela of an intraventricular or subarachnoid hemorrhage.


Delusional disorder, persecutory type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual is being malevolently treated (for example, maligned, harassed, conspired against, poisoned or drugged) by another person or group.


Mixed Phenotype Acute Leukemia, B/T

description: A very rare mixed phenotype acute leukemia in which the blasts show clear-cut evidence of both B-cell and T-cell lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Infrequent Neoplasm

description: A neoplasm that is uncommon.


Southern tick-associated rash illness

description: A putative Borrelia infection causing acute manifestations similar to Lyme disease, particularly erythema migrans, following the bite of the lone star tick, Amblyomma americanum.


name: Localized Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor confined to area of origin including abdominal lymph nodes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Refractory Osteosarcoma

description: Osteosarcoma that does not respond to treatment.


Cervical Mucoepidermoid Carcinoma

description: A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Soft Tissue Infection

description: A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin.


name: Gastric Neuroendocrine Tumor by AJCC v8 Stage

description: A term that refers to the staging of a gastric neuroendocrine tumor according to the American Joint Committee on Cancer, 8th edition. This staging system applies to gastric "carcinoid" tumors (NET G1 and G2, and rare well-differentiated G3). Gastric high-grade neuroendocrine carcinoma and gastric mixed adenoneuroendocrine carcinoma are not included in this staging system. (from AJCC 8th Ed.)


Refractory AL Amyloidosis

description: AL amyloidosis that does not respond to treatment.


Pure Cutaneous Mastocytosis

description: Mastocytosis that manifests with pure cutaneous involvement.


name: Gastrointestinal Tract Acute Graft Versus Host Disease

description: Acute graft versus host disease occurring in the gastrointestinal tract.


name: Stage III Ampulla of Vater Cancer AJCC v8

description: Stage III includes: IIIA: (T1a, N1, M0); (T1b, N1, M0); (T2, N1, M0); (T3a, N1, M0); (T3b, N1, M0); IIIB: (T4, Any N, M0); (Any T, N2, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. T3a: Tumor directly invading the pancreas (up to 0.5 cm). T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, irrespective of size. N1: Metastasis to one to three regional lymph nodes. N2: Metastasis to four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Hodgkin's disease lymphocyte predominance type stage III

description: Stage III adult Hodgkin disease means the involvement of lymph node regions on both sides of the diaphragm (III), which may also be accompanied by localized involvement of an associated extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or by involvement of both (IIIE + S). Stage III disease may be subdivided by anatomic distribution of abdominal involvement or by extent of splenic involvement. Stage III(1) indicates involvement that is limited to the upper abdomen above the renal vein. Stage III(2) indicates involvement of pelvic and/or para-aortic nodes. Five or more visible splenic nodules on a cut section constitutes extensive splenic involvement. Zero to four nodules is classified as minimal splenic disease. (from PDQ)


Zoonoses

description: Infection by an etiologic agent that can be passed between animals and humans.


Renal Pelvis and Ureter Carcinoma

description: Carcinoma that affects the renal pelvis and ureter.


Bacterial pericarditis

description: Pericarditis that is caused by an infection with a bacterial agent.


Paratesticular malignant neoplasm

description: A primary or metastatic malignant neoplasm that affects the paratesticular structures.


Resectable Malignant Neoplasm

description: Malignant neoplasm that is amenable to surgical resection.


Breast Nevus

description: A benign melanocytic nevus that arises from the breast skin.


Acute Myeloid Leukemia with NPM1-MLF1

description: Acute myeloid leukemia associated with NPM1-MLF1 gene fusion.


Adenocarcinoma in adenomatous polyp

description: A non-invasive or invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


name: Locally Advanced Bladder Squamous Cell Carcinoma

description: Bladder squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Congenital facial nerve palsy

description: Partial or complete paralysis of the facial muscles of one side of an individual's face that is present at birth. It is caused by damage to the seventh cranial nerve.


Low Grade Sarcoma

description: A sarcoma with the morphologic features of a low-grade tumor and presence of cellular differentiation.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 1, Children's Oncology Group (COG) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 1 Toronto childhood cancer staging guidelines v2, Children's Oncology Group (COG) protocol.


name: Vulvar Small Cell Neuroendocrine Carcinoma

description: A rare small cell neuroendocrine carcinoma that arises from the vulva.


Peritoneal Infection

description: An infectious process affecting the peritoneum.


Stage IVA Vaginal Cancer AJCC v6 and v7

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4).  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Advanced Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Work shift change (disorder)

description: A subtype of circadian rhythm sleep disorder in which the individual exhibits a normal endogenous pattern of sleep and wakefulness, but this pattern comes into conflict with the desired pattern of sleep and wakefulness required by shift work.


Stage IIB Cervical Cancer FIGO 2018

description: Cervical carcinoma with parametrial involvement but not up to the pelvic wall. (FIGO 2018)


Parapsoriasis en Plaques

description: A variant of parapsoriasis in which the plaques are large.


Unresectable Cutaneous Melanoma

description: A skin melanoma that is not amenable to surgical resection.


Cutaneous Perineurioma

description: A rare perineurioma arising from the skin.


Late Prosthetic Valve Endocarditis

description: Prosthetic valve endocarditis that occurs several months to years following valve replacement.


name: Recurrent Atypical Chronic Myeloid Leukemia

description: The reemergence of atypical chronic myeloid leukemia after a period of remission.


Radiation damage to artery

description: A damage to arteries caused by radiation therapy.


name: Postoperative Spindle Cell Nodule of the Cervix

description: A rare, benign, non-neoplastic reactive lesion that develops in the cervix at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


name: Metastatic Malignant Neoplasm in the Digestive System

description: A malignant neoplasm that has spread to the digestive system from another anatomic site.


Stage III Cutaneous Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Inflamed Juvenile Conjunctival Nevus

description: A compound nevus that arises from the conjunctiva in children and adolescents. It is characterized by the presence of chronic inflammatory features.


Unresectable Myxoid Liposarcoma

description: A myxoid liposarcoma that is not amenable to surgical resection.


name: Disseminated Intravascular Coagulation Related to COVID-19

description: Disseminated intravascular coagulation in a patient with probable or confirmed acute COVID-19.


name: Stage III Adult Diffuse Mixed Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Appendix Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas of the appendix, including high-grade neuroendocrine carcinomas, mixed adenoneuroendocrine carcinomas, and goblet cell carcinoids. Well-differentiated neuroendocrine tumors (carcinoids) are staged according to the classification for neuroendocrine tumors of the appendix. (from AJCC 8th Ed.)


Stage IA Vulvar Carcinoma AJCC v6

description: Stage IA includes: Tia, N0, M0.  T1a: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion no greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Adenocarcinoma of the prostate stage II

description: Stage II includes: IIA (T1a-c, N0, M0, PSA less than 20, Gleason 7); (T1a-c, N0, M0, PSA equal or more than 10 and less than 20, Gleason equal or less than 6); (T2a, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA less than 20, Gleason equal or less than 7); (T2b, N0, M0, PSA X, Gleason X); IIB (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  T2c: Tumor involves both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason 7: Moderately differentiated (moderate anaplasia).  Gleason Equal or Less than 6: Well differentiated (slight anaplasia).  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


name: Advanced Malignant Digestive System Neoplasm

description: A malignant digestive system neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Localized Gastric Adenocarcinoma

description: An adenocarcinoma that arises from the stomach and has not spread to other anatomic sites.


Subjective Fever

description: A symptom report of fever without an objective temperature measurement.


name: FIGO Stage III Gestational Trophoblastic Tumor

description: Lesion affects the lungs, with or without known genital structures invasion.


name: Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: A chronic myeloid leukemia, BCR-ABL1 positive occurring during childhood.


Mucosal nodular melanoma

description: Nodular melanoma that arises from a mucosal site.


Stage IIB Cervical Cancer FIGO 2009

description: Cervical carcinoma with parametrial invasion. (FIGO 2009)


name: Stage IVB Gestational Trophoblastic Tumor AJCC v7

description: Stage IVB includes: Any T, M1b, Risk factors: high risk.  M1b: All other distant metastasis.  (AJCC 7th ed.)


ALK-Positive Histiocytosis

description: A rare histiocytic neoplasm associated with ALK gene rearrangement leading to activation of signaling pathways. The neoplastic cells have a mature histiocytic phenotype, and usually have a foamy cytoplasm. It is characterized by frequent neurologic involvement and responds to ALK inhibition treatments.


Astler-Coller B3 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: FIGO Stage IIA Gestational Trophoblastic Tumor


Liquid Tumor

description: A malignant tumor that originates from myeloid or lymphoid cells i.e., leukemias and lymphomas.


Benign fibrohistiocytic neoplasm

description: A mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases.


name: Bone Malignant Peripheral Nerve Sheath Tumor

description: An exceedingly rare malignant peripheral nerve sheath tumor that arises from the bone.


name: Lung Adenocarcinoma with Mixed Bronchioloalveolar and Invasive Components

description: A lung adenocarcinoma consisting of a bronchioloalveolar component and an invasive adenocarcinomatous component.


Stage II Bone Cancer AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Sarcoma of pelvis

description: Sarcoma involving the organs and structures of the pelvis.


Refractory Anaplastic Astrocytoma

description: An anaplastic astrocytoma that is resistant to treatment.


name: Old Burn Scar-Related Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma of the skin that arises from burn scars. It usually manifests between 20 and 40 years after the original burn.


name: Cervical Invasive Stratified Mucinous Adenocarcinoma

description: A rare, distinct form of invasive cervical mucinous adenocarcinoma associated with human papillomavirus infection. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin.


Stage IVB Appendix Carcinoma AJCC v7

description: Stage IVB includes: (Any T, N0, M1a, G2, G3); (Any T, N1, M1a, Any G); (Any T, N2, M1a, Any G).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-3 regional lymph nodes.  N2: Metastasis in four or more regional lymph nodes.  M1a: Intraperitoneal metastasis beyond the right lower quadrant, including pseudomyxoma peritonei.  G2: Moderately differentiated tumor. G3: Poorly differentiated tumor.  (AJCC 7th ed.)


Neoplasm of uncertain behavior

description: A neoplasm displaying morphologic, phenotypic, or genotypic characteristics that are clearly not benign but do not permit the establishment of a definitive diagnosis of malignancy.  Such neoplasms may or may not eventually have a more aggressive clinical course.  Representative examples include lymphoproliferations of uncertain malignant potential (e.g., lymphomatoid granulomatosis and lymphomatoid papulosis), borderline ovarian epithelial neoplasms (e.g., borderline ovarian endometrioid tumor and borderline ovarian mucinous tumor), borderline exocrine pancreatic neoplasm (e.g., pancreatic borderline intraductal papillary-mucinous neoplasm), and primary borderline peritoneal epithelial neoplasm.


Hernia, Diaphragmatic, Traumatic

description: The protrusion of abdominal cavity contents into the thoracic cavity via a hole in the diaphragm, which was acquired via a traumatic etiology.


Unresectable Urothelial Carcinoma

description: Urothelial carcinoma that is not amenable to surgical resection.


name: Recurrent Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in adulthood after a period of remission.


Metastatic Sarcoma in the Peritoneum

description: A sarcoma that has spread to the peritoneum from an adjacent or distal anatomic site.


Refractory Pancreatobiliary Carcinoma

description: Pancreatobiliary carcinoma that is resistant to treatment.


Acquired phimosis

description: Phimosis that develops in an uncircumcised male with a previously loose foreskin.


name: Platinum-Resistant Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that progresses between one and six months of completing platinum therapy.


Recurrent Langerhans Cell Histiocytosis

description: The reemergence of Langerhans cell histiocytosis after a period of remission.


Disorder of ejaculation

description: A disorder referring to problems related to ejaculation. This category includes premature, delayed, retrograde, and painful ejaculation.


Undifferentiated schizophrenia

description: A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia.


Stent thrombosis

description: The formation of a blood clot of a vessel or heart chamber after and due to the placement of a stent.


name: Stage IIB Nasopharyngeal Keratinizing Squamous Cell Carcinoma


Hairy Polyp

description: A benign polypoid lesion that usually arises from the nasopharynx. It may also occur in the oropharynx, palate, tonsil, tongue, lip, and middle ear. It usually affects neonates and older infants and is composed of ectoderm and mesoderm.


Chronic Bacterial Prostatitis

description: A chronic infection of the prostate gland caused by bacteria.  It is manifested with recurring urinary tract infections.  The culture of the prostatic fluid, semen, or post-massage urine specimen reveals the presence of bacteria.


Stage I Cervical Cancer AJCC v9

description: Stage I includes: T1, N0, M0. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


MAC lymphadenitis

description: Lymph node infection by Mycobacterium avium or Mycobacterium intracellulare. It most often affects children and usually presents with cervical lymph node enlargement. It generally follows a benign clinical course.


Malignant fibrohistiocytic neoplasm

description: A fibrohistiocytic neoplasm that metastasizes to other anatomic sites.


Oligometastatic Prostate Carcinoma

description: Prostate carcinoma that has metastasized to a limited number of sites.


Mixed Morphea

description: The presence of more than one variant of morphea in a single patient.


Stage III Vaginal Cancer AJCC v6 and v7

description: Stage III includes: (T1-3, N1, M0) and (T3, N0, M0). T1: Tumor confined to vagina.  T2: Tumor invades paravaginal tissues but not to pelvic wall.  T3: Tumor extends to pelvic wall.  N0: No regional lymph node metastasis.  N1: Pelvic or inguinal lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: FIGO Grade 1 Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Psammocarcinoma

description: An extremely rare variant of serous carcinoma arising from the ovary or peritoneum. It is characterized by extensive formation of psammoma bodies, low-grade cytological features, and invasion of surrounding structures.


Refractory Adenoid Cystic Carcinoma

description: Adenoid cystic carcinoma that is resistant to treatment.


Recurrent Skin Carcinoma

description: A carcinoma of the skin that has recurred after a period of remission.


name: Locally Advanced Malignant Digestive System Neoplasm

description: A malignant digestive system neoplasm that has spread to nearby tissues or lymph nodes.


name: Stage III Esophageal Adenocarcinoma AJCC v7

description: Stage III includes: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: High-Grade Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia characterized by the presence of high grade epithelial dysplasia.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 1

description: Dyskeratosis congenita caused by autosomal dominant mutation(s) in the TERC gene, encoding telomerase RNA component.


Stage IVA Bone Sarcoma AJCC v7

description: Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Metastatic Neoplasm to the Gallbladder

description: A malignant neoplasm that has spread to the gallbladder from another anatomic site.  Representative examples include metastatic melanoma, and metastatic carcinomas from the breast and the stomach.


name: Appendix Low Grade Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix.  It is characterized by the presence of mild dysplasia and mild architectural alterations of the mucosal epithelium.  There is no evidence of invasion.


name: Neuroendocrine Carcinoma, Excluding Head and Neck

description: A rare aggressive neuroendocrine carcinoma that arises from the skin and most often affects older individuals. It is usually located in the head, neck, and extremities. The tumor is composed of small round cells with scanty cytoplasm. Merkel cell polyomavirus is implicated in the majority of cases.


Thrombosis of blood vessel

description: The formation of a blood clot in the lumen of a vessel; causes include coagulation disorders, and vascular endothelial injury.


Trichoadenoma

description: A rare, benign, slowly growing tumor of the hair follicle occurring usually in the face or buttocks.  Morphologically, it is a well-defined dermal tumor that contains numerous cysts and epithelial islands. The cysts are lined by infundibulum-like squamous epithelial cells.


name: Pathologic Stage III Cutaneous Melanoma AJCC v8

description: Stage III includes: IIIA: (T1a/b-T2a, N1a or N2a, M0); IIIB: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0); IIIC: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0); IIID: (T4b, N3a/b/c, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage I Anal Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or smaller. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


description: A hepatocellular adenoma caused by inactivating mutations of the HNF1A gene.  It is characterized by the presence of lobulated contours, steatosis, and absence of inflammation or nuclear atypia.


name: Simple Endometrial Hyperplasia with Atypia

description: A proliferation of endometrial cells resulting in glandular enlargement and budding without changes in the basic structure of the endometrium. Epithelial atypia is present.


Stage II Cervical Cancer AJCC v7

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood Malignant Central Nervous System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the central nervous system and occurs during childhood.


Juvenile systemic scleroderma

description: Systemic sclerosis that is diagnosed in children. Juvenile systemic sclerosis is more likely to be of the overlap variant and presents with musculoskeletal involvement.


Cancer Fatigue

description: A debilitating tiredness or total lack of energy, often reported as the most common symptom in individuals with cancer.  Cancer fatigue can result from chemotherapy, radiation therapy, surgery, and other treatments; chemotherapy-induced anemia is a very frequent cause. -- 2004


name: Precursor T-lymphoblastic lymphoma/leukemia stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, or nodular involvement of the lungs(s).


name: Clinical Stage III Retinoblastoma AJCC v8

description: Stage III includes: (cT4b, cN0, cM0, Any H); (Any cT, cN1, cM0, Any H). cT4b: Extraocular tumor clinically evident with proptosis and/or an orbital mass. cN0: No regional lymph node involvement. cN1: Evidence of preauricular, submandibular, and cervical lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Metastatic Melanoma in the Viscera

description: A melanoma that has spread to visceral organs from a cutaneous or extracutaneous primary site.


Stage II Testicular Cancer AJCC v8

description: Stage II includes: Any pT/TX, N1-3, M0, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Congenital ankyloblepharon

description: A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue.


Spiradenocylindroma

description: A benign adnexal neoplasm with histological features of both spiradenoma and cylindroma in a single nodular lesion.


Midgut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the jejunum, ileum, proximal colon, or appendix.


Cutaneous Fistula

description: An abnormal communication between the skin and another organ or cavity.


name: Metastatic Genitourinary System Carcinoma

description: A carcinoma that arises from the genitourinary system and has metastasized to other anatomic sites.


name: Unresectable Anal Squamous Cell Carcinoma

description: Anal squamous cell carcinoma that is not amenable to surgical resection.


Malignant cylindroma of skin

description: A carcinoma that arises in a cylindroma.


name: Unresectable Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that is not amenable to surgical resection.


Non-Neoplastic Hair Disorder

description: A non-neoplastic disorder that affects the hair. Representative examples may include alopecia, male pattern baldness, hirsutism, and hair shaft disorders.


name: High Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


name: Acute Myocardial Injury Related to Acute COVID-19

description: Acute myocardial injury in an individual with probable or confirmed COVID-19 infection and no alternative explanation for acute myocardial injury.


name: Lugano Classification Stage IE Adult Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


name: Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent

description: Acute myeloid leukemias and myelodysplastic syndromes arising as a result of the mutagenic effect of alkylating agents that are used for the treatment of malignant tumors. Patients usually develop a myelodysplastic syndrome which may evolve to a higher grade myelodysplastic syndrome or acute myeloid leukemia. A minority of patients present with an acute myeloid leukemia. Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7. Patients with acute myeloid leukemia usually do not respond to treatment and have an unfavorable clinical outcome.


Seminal Vesicle Squamous Cell Carcinoma

description: An extremely rare squamous cell carcinoma that arises from the seminal vesicle. Glandular formation and mucin secretion are absent.


name: Childhood Diffuse Astrocytoma, MYB-Altered

description: A rare diffuse astrocytoma, MYB-altered that occurs during childhood.


Infection by human herpesvirus 6

description: An infection that is caused by human herpesvirus-6.


name: Intermediate Grade Lung Neuroendocrine Neoplasm

description: An intermediate grade malignant neoplasm with neuroendocrine differentiation that arises from the lung.  This category includes atypical carcinoid tumor.


Disorder of AMH Receptor

description: A defect in the Anti-Muellerian hormone receptor.


name: Childhood L2 Acute Lymphoblastic Leukemia

description: L2 acute lymphoblastic leukemia that occurs during childhood.


Sinonasal Chondromesenchymal Hamartoma

description: A benign, locally destructive, sinonasal tumor-like growth containing mixed mesenchymal elements. (WHO 2017)


name: Mitochondrial Hydroxyacyl-Coenzyme A Dehydrogenase Hyperinsulinism

description: Hyperinsulinism due to inactivating mutation(s) in the gene HADH, encoding mitochondrial (short-chain) hydroxyacyl-coenzyme A dehydrogenase, resulting in loss of inhibition of glutamate dehydrogenase (GDH). This condition is also characterized by protein-induced hypoglycemia, but in contrast to GLUD1-associated hyperinsulinism, hyperammonemia is absent.


name: Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

description: A cervical squamous cell carcinoma associated with human papillomavirus infection.


Circumferential Endothelial Hyperplasia

description: Intraluminal hyperplasia of endothelial cells, encircling the entire lumen.


name: Refractory Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that is resistant to treatment.


Clostridium difficile infection

description: A bacterial infection caused by Clostridium difficile (Clostridioides difficile), which is a spore-forming, toxin-producing Gram-positive anaerobic bacillus that is transmitted by the fecal-oral route. Infection may cause symptoms ranging from diarrhea to life-threatening inflammation of the colon, and risk factors include use of antibiotic medication, advanced age, and hospital or long-term care facility admission.


Stage I Uterine Corpus Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


acute systolic congestive heart failure

description: Acute congestive heart failure due to reduced contractility of the left ventricle.


Second degree uterine prolapse

description: The uterus has descended to the level of the hymen.


Atrophic Actinic Keratosis

description: Actinic keratosis characterized by the presence of marked epidermal atrophy.


name: High grade glandular intraepithelial neoplasia

description: A high grade intraepithelial neoplasia in which there is marked architectural distortion and crowding of the glands, associated with severe cellular atypia. The neoplastic cells display pleomorphic and hyperchromatic nuclei.


Malignant tumor of epidermal appendage

description: A malignant neoplasm that arises from the skin appendages.


name: Stage III Adult Diffuse Large Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


Lipomatosis of Nerve

description: A tumor composed of mature adipocytes and fibrous tissue infiltrating the epineurium and peripheral nerves.  It is often seen at birth or during childhood and may be associated with macrodactyly.


name: Human Papillomavirus-Related Anal Squamous Cell Carcinoma

description: An anal squamous cell carcinoma related to infection with sexually transmittable human papillomavirus.


Helicobacter Pylori-Related Carcinoma

description: A carcinoma that is caused by Helicobacter pylori.


Unresectable Neuroendocrine Tumor

description: A neuroendocrine tumor that is not amenable to surgical resection.


Local infection skin/subcut tissue NOS

description: An infection involving the surface of the skin and subcutaneous tissues in a defined area of the body.


name: Stage IIIB Uterine Corpus Cancer AJCC v7

description: Stage IIIB includes: T3b, N0, M0.  T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Metastatic Non-Functioning Neuroendocrine Tumor

description: A non-functioning, well-differentiated neuroendocrine neoplasm that has spread from the original site of growth to another anatomic site.


name: High Grade Prostatic Intraepithelial Neoplasia, Foamy Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of large glands with papillary infoldings that contain cells with xanthomatous cytoplasm.


Childhood Fibrous Histiocytoma

description: A fibrous histiocytoma that occurs during childhood.


name: Monoclonal B-cell lymphocytosis non-chronic lymphocytic leukemia type

description: Monoclonal B-cell lymphocytosis characterized by the presence of fewer than 5 x 10^9/L abnormal B-lymphocytes in peripheral blood and absence of the characteristic immunophenotype of chronic lymphocytic leukemia. This type of monoclonal B-cell lymphocytosis does not progress to chronic lymphocytic leukemia.


Lacrimal Drainage System Carcinoma

description: A carcinoma that arises from the lacrimal sac, canaliculi, or nasolacrimal duct.


Chronic Intestinal Cryptosporidiosis

description: A chronic infection caused by Cryptosporidium parvum or hominis that manifests as enteritis. It usually occurs in immunocompromised patients including persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies.


Cortical Cataract Grade 2

description: A stage of cortical cataract characterized by 10-50% of the intrapupillary space obscured by opacity. (Modified LOCS II)


name: Vaccine associated paralytic poliomyelitis

description: A rare, paralytic poliomyelitis associated with the orally administered live attenuated strain of the poliovirus, OPV.


name: Esophageal Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage

description: A term that refers to the postneoadjuvant therapy staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Stage III Cervical Cancer FIGO 2018

description: Cervical carcinoma that involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para-aortic lymph nodes. (FIGO 2018)


name: Metastatic Malignant Digestive System Neoplasm

description: A malignant neoplasm that arises in the digestive system and has spread from its original site of growth to other anatomic sites.


name: Stage IV Pancreatic Cancer AJCC v6 and v7

description: Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


name: Recurrent Fallopian Tube Mucinous Adenocarcinoma

description: The reemergence of fallopian tube mucinous adenocarcinoma after a period of remission.


Bladder Granular Cell Tumor

description: A rare granular cell tumor arising from the bladder. Most tumors are benign.


Epididymal Cystadenoma

description: A benign cystadenoma that arises from the epididymis.


Venous lake

description: A condition that is characterized by venous dilation, which presents as soft, compressible lesions.


name: Central Nervous System Neoplasms, Primary

description: A benign or malignant neoplasm that arises from the brain or the spinal cord.


Cystic urethritis

description: A reactive inflammatory disorder affecting the urethra.  It is characterized by the development of small cysts in the urethral wall.  The cysts are lined by urothelial cells.


Substance Withdrawal Delirium

description: A disorder characterized by the acute and sudden development of changes in attention, memory, language and/or perception that can be etiologically linked to the direct physiological consequences of substance withdrawal.


Venous Angioleiomyoma

description: A morphologic variant of angioleiomyoma characterized by the presence of thick-walled veins.


Malignant neoplasm musculoskeletal

description: A primary or metastatic malignant neoplasm that affects muscles and bones.


Childhood Benign Bone Neoplasm

description: A childhood neoplasm that arises from bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Direct Contact Transmission Infection

description: Infection produced by direct contact with another person.


Congenital hydroureter

description: Dilatation of the ureter caused by obstruction of urine flow that is present at birth.


Vulval Infection

description: An infectious process affecting the vulva. Causative agents include human papillomavirus, herpes virus, Trichomonas, and Candida. Symptoms include itching and pain in the genital area and discharge.


name: Adult Lymphocyte-Rich Classical Hodgkin Lymphoma

description: Lymphocyte-rich classic Hodgkin lymphoma that occurs in adults.


Conjunctival Compound Nevus

description: A compound nevus that arises from the conjunctiva. It usually occurs in the bulbar conjunctiva, caruncle, and plica semilunaris. It is characterized by the presence of nevus cells within the epithelium and in the substantia propria. Type A nevus cells are present in the junctional nests and superficial substantia propria, and type B nevus cells are present in the deeper layers of the subepithelial compartment.


Childhood Acute Myelomonocytic Leukemia

description: An acute myelomonocytic leukemia occurring in children.


name: Pneumococcal arthritis and polyarthritis


Aggressive osteoblastoma

description: An osteoblastoma characterized by the presence of prominent epithelioid osteoblasts and recurrences.


name: Advanced Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Childhood Benign Neoplasm

description: A neoplasm that occurs during childhood and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Periventricular Nodular Heterotopia

description: A genetically heterogenous condition characterized by round, nodular masses of normal neurons and glial cells with no laminar organization near the ventricles. Patients often develop drug-resistant epilepsy.


Refractory Malignant Brain Neoplasm

description: A malignant brain neoplasm that is resistant to treatment.


Stage IB Bone Sarcoma AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Invasive Ureter Urothelial Carcinoma with Glandular Differentiation

description: An invasive urothelial carcinoma of the ureter that exhibits glandular differentiation.


name: Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement

description: An acute lymphoblastic leukemia with rearrangement of the KMT2A gene that occurs in infancy.


Multicystic mesothelioma, benign

description: A mesothelial neoplasm that arises from the peritoneum and rarely the pleura. It is characterized by the presence of multiple cysts lined by flattened or cuboidal mesothelial cells. There is no evidence of significant cytologic atypia or increased mitotic activity. It may reoccur. Rare cases of transformation to malignant mesothelioma have been reported.


name: Hematologic Neoplasm with Germline ETV6 Mutation

description: Autosomal dominant familial thrombocytopenia associated with germline ETV6 mutation and hematologic malignancies. The hematologic malignancies reported are diverse, including myelodysplastic syndrome, acute myeloid leukemia, chronic myelomonocytic leukemia, B lymphoblastic leukemia, and plasma cell myeloma. Non-hematological neoplasms, including colorectal adenocarcinoma, have been also reported in affected families. (WHO 2017)


supravesical fissure of urinary bladder

description: A urogenital anomaly characterized by infraumbilical exstrophy of a bladder open only in its upper portion and pubic diastasis.  It has been described in both males and females and may be associated with trisomy 18, omphalocele, and urethral duplication.


Lymphangitis carcinomatosa

description: Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination.  The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma.


name: Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8

description: Stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Intratubular large cell hyalinizing Sertoli cell neoplasia

description: A clinically benign intratubular neoplastic proliferation of large Sertoli cells in the testis. It is associated with prominent basement membrane deposits. It occurs almost exclusively in patients with Peutz-Jeghers syndrome.


Voiding Disorders

description: A group of conditions comprising dysfunction of the storage and elimination of urine.


HIV-Related Thrombocytopenia

description: Thrombocytopenia that occurs in patients with acquired immunodeficiency syndrome.


Spongioneuroblastoma

description: A neuroectodermal tumor composed of neoplastic neural elements.


Hypertensive emergency

description: Hypertensive crisis with acute or ongoing end-organ damage.


name: Stage IV Gestational Trophoblastic Tumor AJCC v7

description: Stage IV includes: (Any T, M1b, Risk factors: unknown); IVA (Any T, M1b, Risk factors: low risk); IVB (Any T, M1b, Risk factors: high risk).  M1b: All other distant metastasis.  (AJCC 7th ed.)


name: Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8

description: Stage IA includes: (T1a, N0, M0, G1); (T1a, N0, M0, GX). T1a: Tumor invades the lamina propria or muscularis mucosae. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well-differentiated. GX: Grade cannot be assessed. (AJCC 8th ed.)


Childhood Giant Cell Tumor of Bone

description: A giant cell tumor of bone that occurs during childhood.


name: Differentiated vulvar intraepithelial neoplasia

description: HPV-negative vulvar squamous intraepithelial proliferation characterized by atypia of the basal and parabasal keratinocytes in an otherwise well-differentiated epithelium. Despite its subtle appearance, it has a high risk of malignant transformation. (WHO 2020)


name: Stage II Contiguous Adult Diffuse Large Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Gallbladder Hyperplastic Polyp

description: A polypoid tumor that arises from the gallbladder.  It is characterized by the presence of elongated, serrated crypts lined by proliferative epithelium.


name: Hernia of unspecified site without mention of obstruction or gangrene

description: The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, without mention of obstruction or necrosis of the herniated contents.


Stage IB2 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma equal or more than 2 cm and less than 4 cm in greatest dimension. (FIGO 2018)


Combined Nevus

description: A nevus that contains two or more melanocytic nevus components in the same lesion. The cellular components can be any combination of any nevus variants, but most frequently, a common nevus component is combined with a blue nevus, deep penetrating nevus, or Spitz nevus component. (WHO 2018)


Luminal A Prostate Carcinoma

description: Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a lower proliferation score than the luminal B and basal-like prostate carcinomas.


Pancreatic Medullary Carcinoma

description: A pancreatic ductal adenocarcinoma characterized by poor differentiation and a prominent syncytial growth pattern.  The prognosis is more favorable compared to conventional pancreatic ductal adenocarcinoma.


name: Refractory Urethral Urothelial Carcinoma

description: Urethral urothelial carcinoma that is resistant to treatment.


Acute perforated appendicitis

description: Acute appendicitis with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.


name: Childhood Hematopoietic and Lymphoid Cell Neoplasm

description: A neoplasm of hematopoietic and lymphoid cell origin that occurs during childhood. Representative examples include acute leukemias and lymphomas.


name: Refractory Acute Graft Versus Host Disease

description: Acute graft versus host disease that is resistant to treatment.


Childhood Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma that arises from the central nervous system and occurs during childhood.


CNS metastases

description: A malignant neoplasm that has spread to the central nervous system from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


Refractory Uterine Corpus Cancer

description: Uterine corpus cancer that is resistant to treatment.


Stage IVA Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to adjacent pelvic organs. (FIGO 2018)


name: Unresectable Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that is not amenable to surgical resection.


Dystonia 11, Myoclonic

description: An autosomal dominant condition caused by mutation(s) in the SGCE gene, encoding epsilon-sarcoglycan. It is characterized by myoclonus of the proximal muscles and dystonia.


Incontinent Epispadias

description: Epispadias with urinary incontinence.


name: Acute Myeloid Leukemia with a Variant KMT2A Rearrangement

description: A term referring to acute myeloid leukemias with rearrangement of the KMT2A gene that results in translocations with various genes other than the MLLT3 (AF9) gene.


name: Gestational Trophoblastic Tumor by AJCC v7 Stage

description: A term that refers to the staging of gestational trophoblastic tumor according to the American Joint Committee on Cancer, 7th edition.


Metastatic malignant neoplasm to kidney

description: The spread of a malignant neoplasm to the kidney.  This may be from a primary kidney malignant neoplasm involving the opposite kidney, or from a malignant neoplasm at a distant site.


Gastrointestinal Carcinomatosis

description: Carcinoma that has spread diffusely to the gastrointestinal system.


name: Allergic contact dermatitis caused by Arnica

description: Dermatitis caused by an allergic reaction to arnica.


name: Indolent T-cell lymphoproliferative disorder of gastrointestinal tract

description: A clonal T-cell lymphoproliferative disorder that can involve the mucosa in all sites of the gastrointestinal tract, but is most common in the small intestine and colon. The lymphoid cells infiltrate the lamina propria but usually do not show invasion of the epithelium. The clinical course is indolent, but most patients do not respond to conventional chemotherapy. A subset of cases progress to a higher-grade T-cell lymphoma with spread beyond the gastrointestinal tract. (WHO 2017)


Brain Low Grade Glioma

description: A low-grade glioma that arises from the brain.


name: Acute Myeloid Leukemia with BCOR Mutation

description: An acute myeloid leukemia associated with BCOR gene mutation.


name: Advanced Malignant Genitourinary System Neoplasm

description: A malignant genitourinary neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refluxing Obstructed Megaureter

description: A megaureter in which there is retrograde flow of urine and a concomitant, episodic obstruction resulting from ureteral folding.


Uterine Corpus Germ Cell Tumor

description: A benign or malignant germ cell tumor that arises from the uterine corpus. Representative examples include teratoma and yolk sac tumor.


name: Postneoadjuvant Therapy Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Prostate Adenocarcinoma by AJCC v7 Stage

description: A term that refers to the staging of prostate adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Non-Neoplastic Appendix Disorder

description: A non-neoplastic disorder that affects the appendix.


name: Lymphoproliferative Disorder of the Skin

description: A lymphoproliferative disorder that affects the skin.


CARBONIC ANHYDRASE I DEFICIENCY

description: Decreased or absent activity of the enzyme carbonic anhydrase 1, due to loss-of-function mutation(s) in the gene CA1.


Diffuse Astrocytoma, MYB-Altered

description: A rare IDH-and H3-wildtype diffuse astrocytoma characterized by the presence of a monomorphic population of neoplastic cells that exhibit alteration in the MYB gene. This alteration is associated with fusion between MYB gene and a partner gene, usually PCDHGA1, MMP16, and MAML2 genes.


Benign Intracranial Meningioma

description: A grade I, slowly growing meningioma within the cranial cavity.


name: Isolated Non-Pigmented Micronodular Adrenal Hyperplasia

description: A subtype of micronodular adrenal hyperplasia, characterized by multiple non-pigmented nodules.


name: Metastatic Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Fallopian Tube Cancer by AJCC v7 Stage

description: A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 7th edition.


Type E Lymphomatoid Papulosis

description: A variant of lymphomatoid papulosis characterized by the presence of atypical lymphocytes which exhibited distinct angioinvasion.


Upper aerodigestive tract infection

description: An infectious process affecting the oral cavity, pharynx, and/or larynx.


Benign neoplasm of lymph vessels

description: A benign neoplasm arising from the lymphatic vessels.


Coup de sabre scleroderma

description: A type of linear scleroderma characterized by a linear, colorless, atrophied band across the forehead or scalp. This disorder can affect the tissues under or near the lesion including brain, bone and eyes.


Vulvar Merkel Cell Carcinoma

description: A Merkel cell carcinoma that arises from the vulva. It usually presents as a cutaneous nodular lesion. Most small cell neuroendocrine carcinomas of the vulva are Merkel cell carcinomas.


Leukemia, Eosinophilic, Acute

description: A poorly defined concept which at best is described as an extremely rare entity, possibly related to various subtypes of acute myeloid leukemia with abnormal eosinophils.  (WHO, 2001)


Stage IA Bone Cancer AJCC v8

description: Stage IA includes: T1, N0, M0, G1 or GX. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


Chondroblastoma, malignant

description: A rare chondroblastoma that has metastasized to another anatomic site.


name: Human Papillomavirus-Related Cervical Adenocarcinoma In Situ

description: Cervical adenocarcinoma in situ associated with human papillomavirus infection.


Condyloma acuminata of vagina

description: A human papillomavirus-related neoplasm that arises from the vagina. It is characterized by papillomatosis, acanthotic changes, and hyperkeratosis. Koilocytosis is usually present.


Disease due to Papovaviridae

description: An infection caused by any papovavirus.


name: Lugano Classification Stage IIE Childhood Hodgkin Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Melanoma Metastatic in the Brain

description: A melanoma that has spread to the brain from its original site of growth, through the hematogenous route.


name: T Acute Lymphoblastic Leukemia with TLX1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of TLX1 gene rearrangement.


name: Vaginal high grade squamous intraepithelial lesion

description: Vaginal intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes.


name: Stage II Low Grade Adult Non-Hodgkin's Lymphoma


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 2

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the NHP2 gene, encoding H/ACA ribonucleoprotein complex subunit 2.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2.


name: AIDS-Related Human Papillomavirus Infection

description: An opportunistic infection caused by the human papillomavirus in a patient with AIDS.


Stage III Fallopian Tube Cancer AJCC v7

description: Stage III includes: (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c, N0, M0); (Any T, N1, M0).  T3: Tumor involves one or both fallopian tubes, with peritoneal implants outside the pelvis.  T3a: Microscopic peritoneal metastasis outside the pelvis.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


small cell carcinoma of anal canal

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal.  It is characterized by the presence of malignant small cells.


Recurrent Mesonephric Adenocarcinoma

description: The reemergence of mesonephric adenocarcinoma after a period of remission.


Mixed cell adenocarcinoma

description: An adenocarcinoma characterized by the presence of a mixed malignant glandular cell population.


name: Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma

description: Renal pelvis and ureter urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage III Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Common Carotid Trunk

description: Common origin for left subclavian and left carotid arteries.


name: Central Nervous System Rosai-Dorfman-Destombes Disease

description: Rosai-Dorfman-Destombes disease affecting the central nervous system. It presents with localized or multiple dural masses, parenchymal, and/or intrasellar lesions.


Malignant tumor of seminal vesicle

description: A primary or metastatic malignant neoplasm that affects the seminal vesicle.


Stage IIIC2 Cervical Cancer FIGO 2018

description: Cervical carcinoma with para-aortic lymph node metastasis. (FIGO 2018)


Gallbladder Cancer by AJCC v8 Stage

description: A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to gallbladder carcinomas. Well-differentiated neuroendocrine tumors and sarcomas are not staged using this staging system. (from AJCC 8th Ed.)


name: T Acute Lymphoblastic Leukemia with LMO1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of LMO1 gene rearrangement.


Stage I Vaginal Cancer AJCC v6 and v7

description: Stage I includes: (T1, N0, M0).  T1: Tumor confined to vagina.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


High Grade Mucinous Carcinoma Peritonei

description: A high-grade mucinous adenocarcinoma that has spread to the peritoneum.


Stage 0 Uterine Corpus Cancer AJCC v6

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Neonatal disorder

description: A non-neoplastic or neoplastic disorder which occurs during the neonatal period.


Leptomeningeal Neoplasms

description: A malignant neoplasm that has spread from its original site to the two innermost layers of tissue that cover the brain and spinal cord.


Secondary Osteosarcoma

description: An osteosarcoma arising from a pre-existing lesion of the bone, usually Paget disease, or due to radiation therapy.


name: Refractory Primary Malignant Central Nervous System Neoplasm

description: A primary malignant central nervous system neoplasm that is resistant to treatment.


name: Metastatic Pancreatic Squamous Cell Carcinoma

description: Pancreatic squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Clear Cell Tumor with Melanocytic Differentiation and ACTB-MITF Translocation

description: A clear cell tumor with melanocytic differentiation characterized by a cytogenetic translocation between ACTB and MITF genes that results in ACTB-MITF gene fusion.


name: Stage M4 Childhood Ependymoma by Toronto Guidelines v2

description: Metastasis outside of the central nervous system. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Hypertensive episode

description: An episode of elevated blood pressure.


FGFR3 Chondrodysplasia

description: A constellation of disorders involving mutations of the FGFR3 gene, which result in abnormal growth of bone and cartilage; this includes achondroplasia and hypochondroplasia.


name: Conjunctival Reactive Epithelial Hyperplasia

description: A non-neoplastic proliferation of the conjunctival epithelium in response to irritating stimuli.


Muscle Invasive Bladder Carcinoma

description: A carcinoma that arises from the bladder mucosa and invades the muscle of the bladder wall.


Stage IIA Appendix Carcinoma AJCC v8

description: Stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Childhood Non-T Non-B Acute Lymphoblastic Leukemia

description: Non-T non-B acute lymphoblastic leukemia that occurs during childhood.


name: Acute Myeloid Leukemia with Myelodysplasia-Related Cytogenetic Abnormalities

description: A group of acute myeloid leukemias classified based on specific karyotype findings.


Non-organic enuresis

description: Involuntary urine release that cannot be attributed to an anatomic or physiologic etiology.


Malignant Trophoblastic Teratoma

description: A malignant germ cell tumor which metastasizes widely and produces high levels of human chorionic gonadotropin.


Disturbance of Temperature Regulation

description: Any condition characterized by an inability to regulate body temperature.


Puerperal sepsis

description: A sustained temperature of 38C (100.4F) or greater beyond the first 24 hours following birth, or a temperature of 39C (102.2F) within the first 24 hours following birth. (adapted from ACOG)


name: Non-Destructive Post-Transplant Lymphoproliferative Disorder

description: A lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by the lack of tissue destruction and the architectural preservation of the involved tissues.  It includes two morphologic variants: plasmacytic hyperplasia and infectious mononucleosis-like lymphoproliferative disorders.


name: Non-T Non-B CALLA Positive Childhood Acute Lymphoblastic Leukemia

description: A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in children.


Fibrosarcoma metastatic

description: Fibrosarcoma that has spread from its original site of growth to another anatomic site.


name: Gallbladder Papillary Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia that affects the gallbladder epithelium.  It is characterized by the presence of intraluminal micropapillary projections.


Stage III Cutaneous Melanoma AJCC v6

description: Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases.  N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s).


Neuroendocrine carcinoma of prostate

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the prostate gland. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


name: Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter

description: The reemergence of renal pelvis and ureter urothelial carcinoma after a period of remission.


Malignant sex-cord stromal tumor

description: A gonadal sex cord-stromal tumor with malignant characteristics.  It includes the poorly differentiated ovarian Sertoli-Leydig cell tumor, malignant ovarian granulosa cell tumor, malignant ovarian steroid cell tumor, and malignant ovarian thecoma.


Functional encopresis

description: An elimination disorder characterized by fecal incontinence, whether involuntary or intentional, which is not due to a medical condition and which occurs in someone who is toilet trained.


Polygonal cell carcinoma

description: A malignant epithelial neoplasm composed of atypical polygonal cells with a large amount of eosinophilic cytoplasm. A representative example is the fibrolamellar hepatocellular carcinoma.


IgG Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgG monoclonal immunoglobulin in the blood or urine.


name: Recurrent Pancreatic Acinar Cell Carcinoma

description: The reemergence of pancreatic acinar cell carcinoma after a period of remission.


Perceptual disturbance

description: A misperception of sensory stimuli.


Infestation

description: Invasion of the body by complex organisms that are typically non-microscopic such as worms and arthropods.


name: Recurrent Malignant Peripheral Nerve Sheath Tumor

description: The reemergence of malignant peripheral nerve sheath tumor after a period of remission.


name: Retinal Pigment Epithelium Adenocarcinoma

description: An adenocarcinoma that arises from the retinal pigment epithelium. The prognosis is good if the tumor has not extended extraocularly.


name: Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

description: An acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A occurring in adults.


name: Lugano Classification Stage II Hodgkin Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Apocrine Cystadenoma

description: A rare, benign cystic neoplasm that arises from the apocrine gland. It is characterized by the presence of papillary-like epithelial projections and more complex architectural patterns compared to apocrine hidrocystoma.


Refractory Pancreatic Carcinoma

description: Pancreatic carcinoma that does not respond to treatment.


Lymphoma stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.