Stage IIB Anal Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Tumor larger than 5 cm. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Mucosal Melanoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Mucosal melanoma that has spread from its primary site to another anatomic site.


name: Recurrent Childhood Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma in childhood after a period of remission.


name: Malignant neoplasm arising from pre-existing spiradenocylindroma

description: A carcinoma that arises in a spiradenocylindroma.


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with High Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of high grade dysplasia.


Lithium Induced Birth Defect

description: Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy.


name: Metastatic Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


name: Platinum-Refractory Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses during platinum therapy or within one month of completing platinum therapy.


Factor XII Inactivation

description: Presence of inactivating antibodies to factor XII in the blood.


name: Papillary cystadenoma, borderline malignancy

description: A serous or mucinous cystic glandular epithelial neoplasm of low malignant potential. It is characterized by the presence of atypical or malignant glandular epithelial cells forming papillary structures with an absence of stromal invasion.


name: Metastatic Unresectable Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection.


name: Benign Outer Hair Sheath and Infundibulum Neoplasm

description: A neoplasm that arises from the outer hair sheath and infundibulum. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Female Reproductive System Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle neoplasm that arises from any part of the female reproductive system and cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings.


Lymphoma, Intermediate-Grade

description: An antiquated term that refers to a non-Hodgkin lymphoma with intermediate grade histologic features.


Non-Neoplastic Splenic Disorder

description: A non-neoplastic disorder that affects the spleen.


SUR1-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the ABCC8 gene result in hyperinsulinism.


name: Stage II Adult Diffuse Large Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Acute Myeloid Leukemia with del(5q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 5 [del(5q)].


name: Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB-MYH11

description: An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of acute myeloid leukemia has a favorable prognosis.  (WHO, 2001)


name: Mucosal Melanoma of the Female Genital Tract

description: A malignant melanocytic neoplasm that arises from a mucosal site of the female genital tract.


name: immune effector cell-associated neurotoxicity syndrome, grade 1

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 7, 8, or 9 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken spontaneously.


name: Metastatic Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread from its original site of growth to another anatomic site.


name: Gestational Trophoblastic Tumor by FIGO Stage


name: IgG4-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG4.


name: Transitional Cell Intraepithelial Neoplasia


Abscess of axilla

description: A collection of pus that has formed in the axilla.


Atheroembolism of renal arteries

description: A cholesterol plaque embolus that has become lodged in the renal vasculature.


name: Malignant Lacrimal Drainage System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the lacrimal drainage system.


Parasite-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific parasite as the causative agent.


Spongioblastoma, Polar

description: A lesion characterized by the presence of neoplastic neuroepithelial cells with palisading nuclei. This lesion implies a morphologic growth pattern and it is not considered a clinicopathological entity.


name: Gastroesophageal Junction Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant small cells.


Atrophy of breast

description: Involution of the breast parenchyma.


name: Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Regional Childhood Retinoblastoma by Toronto Guidelines v2

description: Orbital extension or regional lymph nodes involvement. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Monoclonal B-Cell Lymphocytosis

description: A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma.


Recurrent Adenocarcinoma

description: An adenocarcinoma that has recurred after a period of remission.


name: intraepithelial glandular neoplasia of cervix

description: A neoplastic process that affects the glandular epithelial cells of the cervix.  There is no evidence of invasion.  It is classified as low or high grade.


name: Advanced Childhood Malignant Solid Neoplasm

description: A childhood malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Keratinizing Primary Intraosseous Squamous Cell Carcinoma-Solid Type

description: A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, keratin production, infiltration of the marrow spaces, and osseous resorption.


Advanced Squamous Cell Carcinoma

description: Squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Radiation-Related Angiosarcoma

description: A malignant vascular neoplasm arising in an anatomic site exposed to radiation therapy.


name: Nutritional Vitamin D Deficiency Rickets

description: Nutritional rickets due to dietary deficiency of vitamin D.


Ureteral Kinking

description: The folding of a ureter, which results in the impediment of urine flow.


Urethral caruncle

description: A benign, granulomatous lesion that results from the eversion of a portion of the distal urethra, most often at the posterior edge.


Pancreatic Precancerous Condition

description: A pathologic process that arises from the pancreas and has the potential to evolve into a malignant neoplasm.


Stage III Appendix Carcinoma AJCC v8

description: Stage III includes: IIIA: (T1, N1, M0); (T2, N1, M0); IIIB: (T3, N1, M0); (T4, N1, M0); IIIC: (Any T, N2, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4: Tumor invades the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or mesoappendix, and/or directly invades adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph node measuring 0.2 mm or more) or any number of tumor deposits is present, and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission.


Acute rheumatic endocarditis

description: Inflammation of the endocardium in acute rheumatic heart disease.


Refractory Spindle Cell Sarcoma

description: Spindle cell sarcoma that is resistant to treatment.


Stage I Vulvar Cancer AJCC v6

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.).


name: Hodgkin's Disease, Lymphocyte Depletion, Diffuse Fibrosis

description: A lymphocyte depleted Hodgkin lymphoma characterized by the presence of diffuse fibrosis and a few Hodgkin and Reed-Sternberg cells.


Refractory Ampulla of Vater Carcinoma

description: Ampulla of Vater carcinoma that is resistant to treatment.


name: Acute Myeloid Leukemia with EZH2 Mutation

description: An acute myeloid leukemia associated with EZH2 gene mutation.


name: Stage II Pancreatic Cancer AJCC v6 and v7

description: Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension. T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis. N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


Visual Pathway Melanocytoma

description: A benign neoplastic melanocytic proliferation affecting the optic disk and optic nerve.


name: Metastatic Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that has spread from its original site of growth to other anatomic sites.


name: Recurrent Childhood Acute Lymphoblastic Leukemia

description: The reemergence of acute lymphoblastic leukemia in childhood after a period of remission.


name: Childhood Diffuse Astrocytoma, MYBL1-Altered

description: A rare diffuse astrocytoma, MYBL1-altered that occurs during childhood.


Appendix Intraepithelial Neoplasia

description: A precancerous intraepithelial neoplastic lesion that affects the appendix. It is characterized by low or high grade dysplasia of the mucosal epithelium.  There is no evidence of invasion.


Vaginal intraepithelial neoplasia

description: A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue.  It is classified as low- or high-grade intraepithelial neoplasia.


Recurrent Sarcoma

description: The reemergence of sarcoma after a period of remission.


Locally Advanced Glioma

description: Glioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Infective conjunctivitis

description: An infectious process affecting the conjunctiva.


Acute Cerebrovascular Accidents

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system.


Childhood Grade III Meningioma

description: A grade III meningioma that occurs during childhood.


name: Refractory Juvenile Myelomonocytic Leukemia

description: Juvenile myelomonocytic leukemia that is resistant to treatment.


Benign Lymphoproliferative Disorder

description: A proliferation of lymphocytes without atypia seen in infections, hypersensitivity reactions or autoimmune diseases.


Bronchial Epithelial Hyperplasia

description: Hyperplasia of the bronchial epithelial cells.  It is often associated with squamous metaplasia.


Inverted Squamous Cell Papilloma

description: A benign epithelial neoplasm characterized by an endophytic growth, papillary pattern, and proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


name: Refractory Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that is resistant to treatment.


description: A non-neoplastic disorder arising in an anatomic site exposed to radiation.


Refractory Malignant Solid Neoplasm

description: A malignant solid neoplasm that does not respond to treatment.


Unresectable Bone Sarcoma

description: Bone sarcoma that is not amenable to surgical resection.


name: Childhood Nodular Sclerosis Classic Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in childhood.


name: Stage IIB Ampulla of Vater Cancer AJCC v8

description: Stage IIB includes: T3b, N0, M0. T3b: Tumor extending more than 0.5 cm into the pancreas, or extending into peripancreatic tissue or duodenal serosa without involvement of the celiac axis or superior mesenteric artery. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Advanced Malignant Testicular Germ Cell Tumor

description: A malignant testicular germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Phrenic nerve lesion

description: Intermittent, incomplete or complete paralysis with or without tremors to any of the organs or body parts innervated by the phrenic nerve.


name: Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Delusional disorder, jealous type

description: A subtype of delusional disorder characterized by the central delusional theme that the individual's spouse or lover is unfaithful.


name: Immune Effector Cell Associated Neurotoxicity Syndrome Grade 5

description: Death due to Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) where another cause is not the primary determinant.


Childhood Astrocytoma

description: An astrocytoma that occurs during childhood.


name: Advanced Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Gastroesophageal Junction Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


name: Stage 0 Low Grade Appendix Mucinous Neoplasm (LAMN) AJCC v8

description: Stage 0 includes: Tis(LAMN), N0, M0. Tis(LAMN): Low-grade appendiceal mucinous neoplasm confined by the muscularis propria. Acellular mucin or mucinous epithelium may invade into the muscularis propria. T1 and T2 are not applicable to LAMN. Acellular mucin or mucinous epithelium that extends into the subserosa or serosa should be classified as T3 or T4a, respectively. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Hodgkin's disease nodular sclerosis recurrent

description: The reemergence of nodular sclerosis classic Hodgkin lymphoma after a period of remission.


Metastatic Urachal Urothelial Carcinoma

description: Bladder urachal urothelial carcinoma that has spread to another anatomic site.


Stage IIIC Prostate Cancer AJCC v8

description: Stage IIIC includes: Any T, N0, M0, PSA: Any, Grade Group 5. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 5: Gleason Score 9 or 10, Gleason Pattern 4+5, or 5+4, or 5+5. (AJCC 8th ed.)


Stage III Prostate Cancer AJCC v6

description: Stage III includes: T3, N0, M0, Any G. T3: Tumor extends through the prostatic capsule.  T3a: Extracapsular extension (unilateral or bilateral).  T3b: Tumor invades seminal vesicle(s). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


name: Metastatic Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread from its original site of growth to another anatomic site.


name: Stage IV Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Hematogenous metastases or spread beyond abdomen at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Recurrent Childhood Large Cell Lymphoma

description: The reemergence of childhood large cell lymphoma after a period of remission.


Stage III Uterine Corpus Cancer

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1-T3, N1/N2, M0); IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. T3a: Tumor involves serosa and/or adnexa (direct extension or metastasis). T3b: Tumor involves vagina (direct extension or metastasis) or parametrial tissue. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Infantile Myofibroma

description: A benign, localized, nodular and well-circumscribed neoplasm seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma.


name: Vulvar Large Cell Neuroendocrine Carcinoma

description: A high grade neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant large cells.


BAP1-inactivated melanocytoma

description: A cutaneous melanocytoma caused by the inactivation of BAP1 tumor suppressor gene. It is characterized by the presence of a predominantly intradermal proliferation of large epithelioid melanocytes with a large amount of eosinophilic cytoplasm, and vesicular nuclei with prominent nucleoli. Progression to melanoma is infrequent.


name: Recurrent Malignant Female Reproductive System Neoplasm

description: The reemergence of a malignant female reproductive system neoplasm after a period of remission.


Bilateral Carcinoma

description: A carcinoma that affects both sides of an organ in a simultaneous or non-simultaneous manner.


Stage IVA Bone Cancer AJCC v8

description: Stage IVA includes: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Metastasis in the lung. (AJCC 8th ed.)


name: Squamous cell carcinoma, small cell, nonkeratinizing

description: A squamous cell carcinoma composed of small atypical cells, without morphologic evidence of keratin production.


Adipose Tissue Atrophy

description: Shrinking of adipose tissue.


Unresectable Biliary Tract Carcinoma

description: Biliary tract carcinoma that is not amenable to surgical resection.


Acute Myeloid Leukemia with FIP1L1-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of FIP1L1-RARA fusion protein.


Prostate Cystadenoma

description: A rare cystadenoma affecting the prostate gland. It is characterized by the presence of multilocular prostatic cysts.


Metastatic glioma

description: Glioma that has spread from its original site of growth to another anatomic site.


name: Poor Prognosis Metastatic Gestational Trophoblastic Tumor

description: Metastatic gestational trophoblastic tumor in which risk factors are present.


Hodgkin Lymphoma During Pregnancy

description: Hodgkin lymphoma that occurs during pregnancy.


name: Vaginal Adenocarcinoma of Skene Gland Origin

description: A rare vaginal adenocarcinoma arising from the Skene gland. It is characterized by morphological and immunohistochemical features similar to prostate adenocarcinoma.


Thoracic meningomyelocele

description: A congenital abnormality in the thoracic region of the spine, in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


Adenocarcinoma of the prostate stage IV

description: Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


Central Nervous System Hamartoma

description: A hamartoma that occurs in the central nervous system.


Advanced Malignant Solid Neoplasm

description: A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Dermatitis due to unspecified substance taken internally

description: Dermatitis caused by an allergic reaction to an unspecified ingested substance.


Advanced Fibrosarcoma

description: Fibrosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Necrotic tumor

description: A neoplasm characterized by focal or diffuse tumor cell necrosis.


Cutaneous Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the skin.


Conventional Alveolar Rhabdomyosarcoma

description: An alveolar rhabdomyosarcoma characterized by the presence of large striated muscle cells with clear cytoplasm, giant cells with myoblastic differentiation, and fibrovascular septa.


name: Stage IIIC Fallopian Tube Cancer AJCC v7

description: Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0).  T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Congenital Varicella Zoster Infection

description: An infection, characterized by the rash of chickenpox or shingles, that is caused by the varicella-zoster virus transmitted directly from the mother to the fetus or neonate during late pregnancy or childbirth.


name: Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder

description: An early post-transplant lymphoproliferative lesion characterized by plasmacytic proliferation and architectural preservation of the involved tissues.  It often regresses either spontaneously or after reduction in immunosuppression.  The immunoglobulin genes are not rearranged.  In some cases, a polymorphic or monomorphic post-transplant lymphoproliferative disorder may follow this early lesion.


name: Hodgkin's disease nodular sclerosis stage II

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Retroperitoneal abscess

description: An abscess that is located in the abdominal cavity posterior to the peritoneum.


name: Stage II Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Unresectable Transitional Cell Carcinoma

description: A transitional cell carcinoma which is not amenable to surgical resection.


Congenital Intrahepatic Biliary Atresia

description: A congenital disorder characterized by blockage or absence of the intrahepatic bile ducts.


Recurrent Cytomegalovirus Infection

description: A cytomegalovirus infection that has recurred after a period of remission.


name: Childhood Benign Digestive System Neoplasm

description: A childhood neoplasm that arises from the digestive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Recurrent Extrapulmonary Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary neuroendocrine carcinoma after a period of remission.


Unresectable Angiosarcoma

description: An angiosarcoma that is not amenable to surgical resection.


description: An autosomal dominant condition caused by mutation(s) in the PIK3R2 gene, encoding phosphatidylinositol 3-kinase regulatory subunit beta. It is characterized by mild to severe intellectual disability, megencephaly, polymicrogyria, and postaxial polydactyly.


name: Reactive Epithelial Hyperplasia of the Ciliary Body

description: An increase in cell number and volume of the ciliary epithelium, usually in response to injury. (WHO 2018)


Lacrimal Drainage System Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal sac or nasolacrimal duct.


name: Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor

description: An epithelioid malignant peripheral nerve sheath tumor that does not respond to treatment.


No Cardiac Valve Regurgitation

description: No evidence of any retrograde blood flow through the valve(s) in the heart. (ACC)


name: Lacrimal Drainage System Inverted Papilloma

description: A benign neoplasm of the lacrimal drainage system characterized by an inverted/endophytic or mixed growth pattern. It is the most common epithelial neoplasm of the lacrimal drainage system. (WHO 2018)


Locally Recurrent Endometrial Carcinoma

description: The reemergence of endometrial carcinoma after a period of remission, at or adjacent to the site of the original tumor.


description: A hepatocellular adenoma caused by activating mutations of beta-catenin.  It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis.  There is an increased risk of malignant transformation.


name: Ancylostomiasis due to Ancylostoma duodenale

description: Ancylostomiasis that is caused by infection by Ancylostoma Duodenale.


Stage IV Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Stage IB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Acute Myeloid Leukemia with RAM Immunophenotype

description: A high risk pediatric acute myeloid leukemia with an extremely poor prognosis. The blasts show bright CD56 expression, dim-to-negative expression of CD45 and CD38, and lack of HLA-DR expression. This immunophenotype was named after one of the pediatric patient's initials (RAM), from Children's Oncology Group (COG) clinical trial AAML0531.


Vaginal Endometrioid Adenocarcinoma

description: A rare adenocarcinoma that arises from the vagina with histologic features resembling the endometrioid adenocarcinoma of the endometrium.


Late Disseminated Lyme Disease

description: A late stage of Lyme disease that may present in untreated patients months to years after a tick bite manifested with intermittent bouts of arthralgia, arthritis and neurologic complaints.


name: Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Stage IIB Prostate Cancer AJCC v7

description: Stage IIB includes: (T2c, N0, M0, Any PSA, Any Gleason); (T1-2, N0, M0, PSA equal or more than 20, Any Gleason); (T1-2, N0, M0, Any PSA, Gleason equal or more than 8).  T2c: Tumor involves both lobes.  T1a: Tumor incidental histologic finding in 5% or less of tissue resected.  T1b: Tumor incidental histologic finding in more than 5% of tissue resected.  T1c: Tumor identified by needle biopsy (e.g., because of elevated PSA).  T2a: Tumor involves one-half of one lobe or less.  T2b: Tumor involves more than one-half of one lobe, but not both lobes.  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  Gleason equal or more than 8: Poorly differentiated/undifferentiated (marked anaplasia).  (AJCC 7th ed.)


Dialysis Catheter Infection

description: A local or systemic infection associated with the use of a dialysis catheter.


name: Recurrent Pancreatic Ductal Adenocarcinoma

description: The reemergence of pancreatic ductal adenocarcinoma after a period of remission.


Vaginal Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the vagina. Representative examples include vaginal infection and vaginal fibroepithelial polyp.


Malignant neoplasm of stomach stage II

description: Stage II includes: IIA (T3, N0, M0); (T2, N1, M0); (T1, N2, M0); IIB (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


Nasal Chondromesenchymal Hamartoma

description: A very rare benign lesion that arises from the sinonasal tract. It usually affects infants and children. It presents as a polypoid mass and is composed of cartilage, myxoid stroma, and other mesenchymal elements.


Puerperal endometritis

description: Infection of the endometrium, decidua and/or myometrium occurring at any time between birth and 42 days postpartum.


Superficial spreading adenocarcinoma

description: An adenocarcinoma which has spread within the mucosa without further invasion of the underlying tissues.


name: Stage IV Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Biliary Intraepithelial Neoplasia

description: A neoplastic, non-invasive lesion that affects the biliary epithelium.  It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity.


name: Large B-cell lymphoma arising in HHV8 associated multicentric Castleman disease

description: An aggressive diffuse large B-cell lymphoma occurring in patients with HHV8-positive multicentric Castleman disease. It is characterized by the presence of human herpesvirus 8-infected large B-lymphocytes that resemble plasmablasts. It is usually seen in patients with HIV infection.


Hypertensive Urgency

description: Hypertensive crisis without end-organ damage.


name: Verrucous carcinoma of the oral cavity stage II


Recurrent Anaplastic Ganglioglioma

description: The reemergence of anaplastic ganglioglioma after a period of remission.


Adrenoleukodystrophy, Neonatal

description: A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma.


Wound dehiscence

description: Splitting of the sutured margins of a surgical wound. Risk factors include diabetes mellitus, obesity, and advanced age.


Cribriform comedo-type adenocarcinoma

description: An adenocarcinoma characterized by the presence of malignant cribriform glands with central necrotic changes.


name: Pancreatic Intraductal Tubulopapillary Neoplasm

description: An epithelial neoplasm that arises from the exocrine pancreas characterized by the formation of tubular structures, high grade dysplasia, and ductal differentiation. Grossly, it is characterized by the presence of intraductal nodular masses. Morphologically, there are nodules of tubular glands and occasional papillary structures growing in dilated ducts.  There is no significant mucin production. Signs and symptoms include epigastric pain, weight loss, vomiting, steatorrhea, and diabetes mellitus.


description: Cancer that is not dependent upon the presence of estrogen for metastasis or growth. 2005


Maternal Obesity

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Obesity in a female who has a child.


Atrophy of vagina

description: A condition characterized by the absence of squamous maturation in the vaginal epithelium. It is associated with decreased estrogen production.


Stage IIIA Cervical Cancer AJCC v8

description: Stage IIIA includes: T3a, Any N, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IB2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and more than 4 cm in maximum diameter. (FIGO 2009)


Anal Mucositis

description: An inflammatory process affecting the mucous membrane of the anus.


name: Stage I Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Recurrent Anaplastic Oligodendroglioma

description: The reemergence of anaplastic oligodendroglioma after a period of remission.


Prolonged grief disorder

description: A psychiatric disorder characterized by the personal experience of intense and prolonged yearning for, or preoccupation with the circumstances surrounding, a loss that leads to significant impairment in social or occupational functioning. Associated symptoms may include: identity disruption, disbelief, avoidance of reminders, difficulty moving on, emotional pain or numbness, feeling that life is meaningless, and loneliness.


BK virus infection

description: An infection caused by the BK virus. It usually causes an asymptomatic infection, except in immunocompromised individuals where it may cause nephropathy or hemorrhagic cystitis.


Metastatic Cutaneous Melanoma

description: A melanoma that arises from the skin and has metastasized to another anatomic site.


name: IgG-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by the presence of class-switched immunoglobulin heavy chain expressing IgG.


name: Recurrent Moderate-Severe Chronic Graft Versus Host Disease

description: The reemergence of moderate-severe chronic graft versus host disease after a period of remission.


Locally Advanced Bone Sarcoma

description: Bone sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Factor X Inactivation

description: Presence of inactivating antibodies to factor X in the blood.


Dendritic Blue Nevus

description: A blue nevus characterized by the proliferation of dendritic melanocytes in sclerotic stromal collagen.


Megaureter

description: Enlargement of the diameter of the ureter, which can be partial or complete.


name: Refractory Malignant Peripheral Nerve Sheath Tumor

description: Malignant peripheral nerve sheath tumor that is resistant to treatment.


Cutaneous lymphoma

description: A lymphoma involving the skin.


Seminoma, anaplastic

description: A seminoma of the testis characterized by increased cellular pleomorphism, high mitotic activity, and a non-prominent stromal lymphocytic infiltrate.


NK-lymphoblastic leukemia/lymphoma

description: A precursor lymphoid neoplasm that expresses CD56 and immature T-cell markers, lacks B-lymphoid and myeloid markers, and has immunoglobulin and T-cell receptor genes in the germline configuration.


Cervical Cancer by AJCC v6 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 6th edition.


name: Borderline Ovarian Serous Surface Papillary Tumor

description: A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations that contain atypical serous epithelial cells in the outer surface of the ovary.  There is no evidence of stromal invasion.


Classical Low Grade Fibromyxoid Sarcoma

description: A low grade fibromyxoid sarcoma that may have poorly formed collagen rosettes, but lacks prominent, well formed collagen rosettes.


name: Male Non-Neoplastic Reproductive System Disorder

description: A non-neoplastic disorder that affects the male reproductive system. Representative examples include prostatitis, balanitis, and phimosis.


name: Refractory Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase

description: Polycythemia vera, post-polycythemic myelofibrosis phase that is resistant to treatment.


name: Localized Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that has focally invaded into the bladder muscularis propria.


Progressive Pseudorheumatoid Dysplasia

description: An autosomal recessive condition caused by mutation(s) in the CCN6 gene, encoding cellular communication network factor 6. It is a progressive arthropathy that clinically resembles rheumatoid arthritis but differs in its radiological appearance.


Antepartum Obstetric Thromboembolism

description: Presence of a blood clot in the maternal vascular system which originated from a distant site during the antepartum period.


name: Squamous intraepithelial neoplasia grade 2


name: Good Prognosis Metastatic Gestational Trophoblastic Tumor

description: Metastatic gestational trophoblastic tumor in which risk factors are absent.


Urothelial carcinoma urethra recurrent

description: The reemergence of urethral urothelial carcinoma after a period of remission.


Stage 0 Testicular Cancer AJCC v8

description: Stage 0 includes: pTis, N0, M0, S0. pTis: Testicular cancer with a finding of germ cell neoplasia in situ. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


name: Localized Childhood Retinoblastoma by Toronto Guidelines v2

description: Intraocular tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Cervical meningomyelocele

description: A congenital abnormality in the cervical region of the spine in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface.


name: Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder

description: A monomorphic post-transplant lymphoproliferative disorder that does not respond to treatment.


Encephalopathy Related to COVID-19

description: Encephalopathy in a patient with probable or confirmed acute COVID-19.


name: Stage IIA Pancreatic Cancer AJCC v6 and v7

description: Stage IIA includes: T3, N0, M0.  T3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Hepatobiliary Disorder

description: A non-neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples include hepatitis, cirrhosis, cholangitis, and cholecystitis.


name: Locally Advanced Digestive System Neuroendocrine Tumor G2

description: Digestive system neuroendocrine tumor G2 that has spread from its original site of growth to nearby tissues or lymph nodes.


Induced cataract

description: A cataract that has been produced artificially or by induction, e.g. as a result of device use, medication, trauma, tears, falls, accidental injury, etc.


Stage IA Vulvar Cancer AJCC v7

description: Stage IA includes: T1a, N0, M0. T1a: Tumor confined to the vulva and perineum, 2 cm or less in greatest dimension, and with stromal invasion no greater than 1 mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Metastatic Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread to another anatomic site.


name: Recurrent Digestive System Neuroendocrine Tumor G1

description: The reemergence of digestive system neuroendocrine tumor G1 after a period of remission.


name: Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIB includes: T2, N0, M0. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Esophageal Neuroendocrine Tumor G1

description: A rare, well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The majority of cases have a polypoid appearance, are small lesions, and found incidentally.


name: Transcription Factor-Associated Monogenic Diabetes

description: Monogenic diabetes caused by inactivating mutation(s) in transcription factors regulating expression of pancreatic beta cell genes.


name: Bradyarrhythmia Related to COVID-19 Requiring Temporary or Permanent Pacing

description: Bradycardia (ventricular rate less than 60 bpm) showing signs of hypoperfusion and that requires temporary or permanent pacemaker intervention in a patient with probable or confirmed acute COVID-19.


name: Vaginal intraepithelial neoplasia grade 2

description: Vaginal intraepithelial neoplasia characterized by the presence of nuclear intraepithelial neoplastic changes in the lower two-thirds of the epithelium and parakeratosis.


Anemia due to Increased Destruction

description: Anemia that results from an increased rate of erythrocyte destruction.


Acute pericarditis

description: Acute inflammation of the pericardium.


Skin squamous cell carcinoma recurrent

description: The reemergence of squamous cell carcinoma of the skin after a period of remission.


name: Platinum-Refractory Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that progresses during platinum therapy or within one month of completing platinum therapy.


Stage IVA Cervical Cancer FIGO 2009

description: Cervical carcinoma with rectal or bladder involvement. (FIGO 2009)


Viral gastroenteritis

description: Gastroenteritis resulting from a viral infection.


name: Human Papillomavirus-Related Malignant Neoplasm

description: A malignant neoplasm associated with the presence of human papillomavirus infection.


Metaplastic carcinoma

description: A general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation.


Foveolar-Type Adenoma

description: A rare neoplastic polyp that arises from the stomach.  It is characterized by the presence of foveolar-type epithelium.  It may be seen in patients with familial adenomatous polyposis.


Avascular joint necrosis

description: Death of bone tissue in a joint due to temporary or permanent interruption of blood flow.


Endogenous Infection

description: An infection caused by an infectious agent that is present on or in the host prior to the start of the infection.


Unresectable Malignant Mesothelioma

description: Malignant mesothelioma that is not amenable to surgical resection.


Classic Type Trichilemmoma

description: Trichilemmoma in which there is no evidence of sclerotic stroma formation.


Small Cell Adenocarcinoma

description: An adenocarcinoma composed of small malignant cells.


Non-Congenital Amegakaryocytosis

description: An acquired non-neoplastic disorder characterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


Imperforate Vagina

description: A congenital birth defect characterized by the absence of a normal vaginal opening.


name: Stage IIIC Uterine Corpus Cancer AJCC v7

description: Stage IIIC includes: IIIC1 (T1-T3, N1, M0); IIIC2 (T1-T3, N2, M0). T1: Tumor confined to corpus uteri.  T2: Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus.  Endocervical glandular involvement only should be considered as Stage I and not as Stage II. T3: Tumor involves serosa and/or adnexa, vagina, or parametrial tissue. N1: Regional lymph node metastasis to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes.  M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Central Nervous System Erdheim-Chester Disease

description: Erdheim-Chester disease that affects the central nervous system.


Stage I Appendix Carcinoma AJCC v8

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Malignant Vipoma

description: An aggressive neuroendocrine tumor located in the pancreas or small intestine. It is composed of cells containing vasoactive intestinal peptide.  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria. It displays vascular invasion and metastasizes to other anatomic sites.


Squamoid eccrine ductal carcinoma

description: A variant of ductal eccrine carcinoma with squamoid metaplasia.


name: T Acute Lymphoblastic Leukemia with Recurrent Genetic Abnormalities

description: T-acute lymphoblastic leukemias characterized by the presence of recurring cytogenetic and/or molecular abnormalities.


name: Diffuse Pediatric-Type High Grade Glioma RTK1

description: An aggressive, WHO grade 4 diffuse glioma usually affecting children, adolescents, or young adults. It is characterized by receptor tyrosine kinase type 1 (RTK1) alterations.


Stage IVA Vulvar Cancer AJCC v7

description: Stage IVA includes: (T1/T2, N3, M0); (T3, Any N, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Primary Myelofibrosis

description: Primary myelofibrosis that is resistant to treatment.


Congenital absence of uterus

description: A congenital abnormality characterized by the complete absence of the uterus.


name: Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease

description: Sickle cell-hemoglobin C disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.


name: Dyskeratosis Congenita, Autosomal Dominant 3

description: Dyskeratosis congenita caused by autosomal dominant mutation(s) in the TINF2 gene, encoding TERF1-interacting nuclear factor 2. Mutations in TINF2 may also lead to another phenotype known as Revesz syndrome (Dyskeratosis Congenita, Autosomal Dominant 5).


Refractory Digestive System Carcinoma

description: A carcinoma hat arises from any part of the digestive system and is resistant to treatment.


name: Hematologic Neoplasm with Germline RUNX1 Mutation

description: An autosomal dominant syndrome characterized by abnormalities in platelet number and function and enhanced risk of developing myelodysplastic syndrome/acute myeloid leukemia at a young age. Patients have germline monoallelic mutations in RUNX1 gene. The clinical presentation is variable, even within the same family. Most affected individuals have a mild to moderate bleeding tendency. Platelet counts are normal or mildly reduced, with normal platelet morphology and variable degrees of platelet dysfunction. Distinct families with germline RUNX1 mutations exhibit varying risks of development of myeloid neoplasms with 11-100% (median: 44%) of family members affected. (WHO 2017)


Parietal cell carcinoma

description: An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with eosinophilic, finely granular cytoplasm.


name: Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Refractory Childhood Central Nervous System Neoplasm

description: A central nervous system neoplasm in childhood that is resistant to treatment.


Pancreatobiliary-type carcinoma

description: An invasive adenocarcinoma that arises from the ampulla of Vater. It is characterized by the presence of malignant cells that resemble the malignant cells of the pancreatic ductal or extrahepatic bile duct carcinomas.


name: Bile Duct Mucinous Cystic Neoplasm, High Grade

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of severe atypia.


hepatoid adenocarcinoma of gallbladder

description: A rare variant of gallbladder adenocarcinoma.  It is characterized by the presence of a malignant glandular epithelial infiltrate that resembles hepatocellular carcinoma.


Crystal-Storing Histiocytosis

description: A condition characterized by histiocytes containing intra-lysosomal accumulation of immunoglobulin light chains. Crystal-storing histiocytosis is often associated with plasma cell dyscrasias and lymphoproliferative disorders.


name: Clinical Stage II Esophageal Adenocarcinoma AJCC v8

description: Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Ventilation or Perfusion Signs and Symptoms


name: Neuroendocrine Carcinoma of Unknown Primary

description: A neuroendocrine carcinoma that has metastasized from an  unknown primary site.


name: Preinvasive Neoplasm of the Ampullary Region

description: A premalignant neoplastic and dysplastic lesion that arises from the ampulla of Vater.  It is characterized by the absence of invasion.  This category includes intestinal-type adenomas, noninvasive papillary neoplasms of pancreatobiliary type, and flat intraepithelial neoplasia.


Anal Canal Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the anal canal. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Cyst

description: A sac-like closed membranous structure that may be empty or contain fluid or amorphous material.


Stage IA Esophageal Cancer AJCC v7

description: Stage IA includes: For squamous cell carcinoma: T1, N0, M0, G1, GX, Tumor location: Any. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  For adenocarcinoma: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Metastatic Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has metastasized to another anatomic site.


undifferentiated carcinoma of appendix

description: A high grade carcinoma arising from the appendix, characterized by the absence of glandular or squamous differentiation.


Childhood Esophageal Carcinoma

description: A rare carcinoma of the esophagus that occurs during childhood.


name: Localized Malignant Supratentorial Neoplasm

description: A malignant supratentorial neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Distal Urethral Carcinoma

description: A carcinoma that arises from the distal part of the urethra.


Tuberculosis of adrenal glands

description: Tuberculosis of the adrenal gland.


name: Testicular Sex Cord-Gonadal Stromal Tumor, Mixed Forms

description: A sex cord-stromal tumor of the testis which may contain any combination of cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms include testicular swelling and gynecomastia.


name: Lugano Classification Stage II Bulky Adult Lymphoma AJCC v8

description: Stage II Bulky: Stage II with disease bulk. (from AJCC 8th Ed.)


Schizoaffective disorder, bipolar type

description: Schizoaffective disorder with episodes of mania and depression.


name: Digestive System Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant large cells.


name: Clinical Stage IV Cutaneous Melanoma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Evidence of distant metastasis. (AJCC 8th ed.)


Gastrointestinal Carcinoid Tumor

description: A well differentiated neuroendocrine neoplasm of low grade arising from the digestive system. It is composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with small vesicular nuclei. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The tumor can occur anywhere in the digestive system; approximately 90% arise in the appendix.


Refractory Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that is resistant to treatment.


name: Stage II Adult Diffuse Mixed Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Chemical Gastritis

description: Gastritis caused by injury to the gastric mucosa by chemicals. The injury occurs due to reflux of bile and pancreatic enzymes.


name: Diffuse malignant lymphoma - centroblastic-centrocytic


Stage IIB Gastric Cancer AJCC v7

description: Stage IIB includes: (T4a, N0, M0); (T3, N1, M0); (T2, N2, M0); (T1, N3, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood Ependymoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood ependymoma according to the Toronto childhood cancer staging guidelines v2.


Atrophic arthritis

description: An antiquated term indicating arthritis and bone loss.


Carcinoma in situ of fallopian tube

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (limited to tubal mucosa). N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: MITF Pathway-Activated Melanocytic Tumor

description: A cutaneous neoplasm associated with MITF gene rearrangement and either ACTIN-MITF translocation or MITF-CREM translocation. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis. It presents as a single non-pigmented cutaneous nodule.


small cell carcinoma of appendix

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the wall of the appendix. It is characterized by the presence of malignant small cells.


name: Childhood Pre-B Acute Lymphoblastic Leukemia

description: Pre-B acute lymphoblastic leukemia that occurs during childhood.


In situ follicular neoplasia

description: A follicular neoplasia confined to the germinal centers of the lymph nodes, without evidence of disseminated disease. It is characterized by the replacement of a germinal center by neoplastic centrocytes with uniformly intense positivity for BCL2. The surrounding mantle cuff and lymphoid architecture are intact. It has a low rate of progression to follicular lymphoma, but is often associated with prior or synchronous overt lymphoma.


Benign Familial Infantile Seizures

description: A genetically heterogenous afebrile seizure disorder of infancy, typically occurring between the third and eight month of life, that is characterized by brief partial seizures occurring in clusters over a day or several days. Psychomotor and neurologic development before and after seizures are normal.


name: Refractory Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that is resistant to treatment.


Chronic candidiasis

description: Candidiasis that is persistent or long-standing in nature.


Clear cell adenocarcinoma of lung

description: A well differentiated morphologic variant of lung adenocarcinoma characterized by the predominance of clear cells.


name: Benign Germinative Follicular Epithelium Neoplasm

description: A neoplasm that arises from the germinative follicular epithelium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Benign neoplasm of extrahepatic bile ducts

description: A neoplasm that arises from the extrahepatic bile ducts and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Resectable Oligodendroglioma

description: An oligodendroglioma that is amenable to surgical resection.


name: Localized Gastroesophageal Junction Adenocarcinoma

description: An adenocarcinoma that arises from the gastroesophageal junction and has not spread to other anatomic sites.


Congenital non-progressive ataxia

description: A clinically and genetically heterogenous group of rare, predominantly non-progressive neurological disorders present at birth and characterized by hypotonia, developmental delays, and ataxia. Cognitive and motor impairments may improve over time.


Cervical Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the cervix. Representative examples include endometriosis and cervicitis.


name: Malignant Lymphoma, Non-Cleaved Cell Type


Stage II Vulvar Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Carcinoma Arising in Bladder Diverticulum

description: A carcinoma arising in a bladder diverticulum. Approximately one-third to half of the cases represent non-invasive, low-grade or high-grade urothelial carcinomas. Approximately half of the invasive carcinomas are urothelial. The rest include adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.


Grade 1 Diffuse Follicular Lymphoma

description: A follicular lymphoma with diffuse pattern characterized by the presence of 5 or less centroblasts per 40 high-power fields.


name: Stage IV Low Grade Adult Non-Hodgkin's Lymphoma


Unresectable Osteosarcoma

description: An osteosarcoma which is not amenable to surgical resection.


Giant cell and spindle cell carcinoma

description: A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle cells.


name: Gallbladder Benign Non-Epithelial Neoplasm

description: A non-epithelial neoplasm that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include leiomyoma, lipoma, and neurofibroma.


name: Borderline Fallopian Tube Endometrioid Tumor

description: A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells.  There is no evidence of stromal invasion.


name: Non-T Non-B CALLA Positive Adult Acute Lymphoblastic Leukemia

description: A non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in adults.


name: Pathologic Stage IIA Merkel Cell Carcinoma AJCC v8

description: Stage IIA includes: T2-3, N0, M0. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


Non-Neoplastic Corneal Disorder

description: A non-neoplastic disorder that affects the cornea.


name: Hodgkin's disease mixed cellularity stage I site unspecified

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Vulvar Warty Carcinoma

description: A squamous cell carcinoma that arises from the vulva and is characterized by the presence of a warty surface and cellular changes that are caused by human papillomavirus infection.


name: Appendix Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor arising from the wall of the appendix.  It is characterized by the presence of neoplastic cells forming round solid nests and occasionally glandular structures.  The majority of the cases are asymptomatic, and they are found incidentally in appendectomy specimens.  The majority of the tumors are located in the distal end of the appendix and they are enterochromaffin-cell carcinoid tumors producing serotonin.  Most cases show morphologic evidence of appendiceal wall and lymphatic vessel invasion by tumor cells.  Despite the morphologic evidence of invasion, appendiceal carcinoid tumors only infrequently produce lymph node or distant metastases.


Solid Neoplasm

description: A benign or malignant neoplasm arising from tissues that do not include fluid areas.  Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma).  Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors.


Laboratory Test Result

description: The outcome of a laboratory test.


Intimal dissection

description: A dissection of an artery that occurs though a tear in the inner lining of the blood vessel.


Advanced Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Testicular Yolk Sac Tumor, Postpubertal-Type

description: Testicular yolk sac tumor that is associated with germ cell neoplasia in situ and usually occurs as a component of mixed germ cell tumor. Pure postpubertal-type testicular yolk sac tumor is exceedingly rare.


Paratesticular Mesothelial Neoplasm

description: A mesothelial neoplasm that arises from the paratesticular structures. It includes adenomatoid tumor, well differentiated papillary mesothelial tumor, and malignant mesothelioma.


Tissue Kallikrein Deficiency

description: A disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present.


Cutaneous Melanoma by AJCC v6 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v6 classification system.


Alpha trait thalassemia

description: A condition in which a person has reduced protein production from two of the four alpha-globin alleles.


name: Glandular Cell Intraepithelial Neoplasia


Virus-Related Lymphoma

description: Lymphoma that is caused by a virus infection.


Atypical hyperplasia of breast

description: A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia.


name: Endocrine mucin-producing sweat gland carcinoma

description: A rare, low-grade sweat gland carcinoma with neuroendocrine differentiation. It usually arises on the eyelids and periorbital skin. It affects mostly older individuals. Women are affected more frequently than men. Morphologically, it is characterized by well-demarcated nodules with cystic, papillary, or cribriform architectural patterns. The neoplastic cells are small to intermediate polygonal to round cells. Small amounts of intracellular or extracellular mucin are present. In some cases, this carcinoma is a precursor of mucinous carcinoma.


Refractory Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that is resistant to treatment.


benign fibrous histiocytoma of bone

description: A rare, benign neoplasm usually arising from the non-metaphyseal regions of long bones or pelvis. It is characterized by the presence of fibroblastic spindle cells arranged in a whorled storiform pattern, osteoclast-like giant cells, foam cells, inflammatory cells, hemosiderin deposition and stromal hemorrhage.


Female sexual arousal disorder

description: A disorder characterized by a recurrent or persistent inability to attain or maintain until completion of sexual activity an adequate physical response of sexual excitement, consisting of vasocongestion in the pelvis, vaginal lubrication and expansion, and swelling of the external genitalia.


Solid Alveolar Rhabdomyosarcoma

description: A morphologic variant of alveolar rhabdomyosarcoma.  It is characterized by the presence of a solid growth pattern and the absence of fibrovascular stroma.


Stage IVB Vaginal Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th and 7th eds.)


Spinal Cord Infarct During Birth

description: Ischemic necrosis of the spinal cord due to spinal artery occlusion during the birthing process.


Ptosis

description: A condition in which an organ or body tissue drops or bulges out of place.


Metastatic Meningioma

description: A meningioma that has spread from its original site of growth to another anatomic site.


Residual schizophrenia

description: A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs).


Panniculitis, Peritoneal

description: A disorder characterized by chronic inflammation and fibrosis of the adipose tissues in the peritoneal cavity.


name: Stage III Ampulla of Vater Cancer AJCC v7

description: Stage III includes: T4, Any N, M0. T4: Tumor invades peripancreatic soft tissues or other adjacent organs or structures other than the pancreas.  M0: No distant metastasis. (from AJCC 7th Ed.)


HIV Encephalopathy

description: Encephalopathy that is associated with human immunodeficiency virus (HIV) infection.


Chemical conjunctivitis

description: Inflammation of the conjunctiva in a newborn due to chemical irritation which was acquired postnatally from iatrogenic causes.


Pancreatic Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the pancreas. The Ki-67 index is higher than 20%.


Polygenic Obesity

description: Obesity associated with variations in multiple genes.


Port Site Infection

description: An infection at an anatomic location used for vascular access.


name: Stage III Appendix Neuroendocrine Tumor AJCC v7

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor directly invades other adjacent organs or structures, e.g., abdominal wall and skeletal muscle.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Chronic Myelomonocytic Leukemia-2

description: A chronic myelomonocytic leukemia characterized by the presence of 10-19 percent blasts in the bone marrow and 5-19 percent blasts in the peripheral blood or by the presence of Auer rods regardless of the blasts count.


Grade 2 Diffuse Follicular Lymphoma

description: A follicular lymphoma with diffuse pattern characterized by the presence of 6-15 centroblasts per 40 high-power fields.


Presyncope Related to COVID-19

description: Presyncope in a patient with probable or confirmed acute COVID-19.


name: Ann Arbor Stage II AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Unresectable Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that is not amenable to surgical resection.


Dissociative Hysteria

description: A disorder characterized by sudden, unexpected travel away from one's home or place of work accompanied by an inability to recall one's past; the individual is confused about his or her personal identity and may assume a new identity.


Stage IIA Bone Cancer AJCC v8

description: Stage IIA includes: T1, N0, M0, G2 or G3. T1: Tumor measuring 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


Proximal Gastric Adenocarcinoma

description: A gastric adenocarcinoma that arises from the proximal part of the stomach.


Aplastic anemia due to drugs

description: A state of bone marrow suppression and failure that is caused by a cytotoxic or adverse immunologic response to a drug treatment, leading to a failure of production of red blood cells, white cells and platelets.


Fallopian Tube Cancer by AJCC v6 Stage

description: A term that refers to the staging of fallopian tube carcinoma according to the American Joint Committee on Cancer, 6th edition.


Fistula of gallbladder

description: An abnormal communication between the gallbladder and another organ or cavity.


Aorticopulmonary Septal Defect

description: A congenital heart malformation characterised by incomplete separation of the truncus arteriosus and the aorticopulmonary trunk, resulting in communication between the aorta and pulmonary trunk.


name: High Grade Gastric Intraepithelial Neoplasia

description: A gastric intraepithelial lesion characterized by the presence of neoplastic cells that are cuboidal with a high nucleus to cytoplasmic ratio, prominent nucleoli, significant architectural changes, and increased number of mitotic figures.


Early Inflammatory Arthritis

description: Early stages of inflammatory arthritis, when the underlying diagnosis is uncertain, usually little or no joint damage has occurred. Treatment may alter the disease course (e.g., potentially avert progression to full RA or other diagnosis).


name: FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Acute on chronic systolic heart failure

description: Acute decompensation of chronic systolic congestive heart failure.


Diffuse Meningeal Melanocytic Neoplasm

description: A diffuse proliferation of melanocytes that affects the leptomeninges. This category includes melanocytosis and melanomatosis.


name: Adult Acute Myeloid Leukemia with Minimal Differentiation

description: An acute myeloid leukemia with minimal differentiation occurring in adults.


name: Non-Neoplastic Respiratory System Disorder

description: A non-neoplastic disorder that affects the respiratory system.  Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis.


name: Metastatic Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Distant metastases present at diagnosis. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Prostate Ductal Adenocarcinoma, Cribriform Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of neoplastic large back-to-back glands with slit-like lumens.


Adult Pineocytoma

description: A pineocytoma occurring in adults.


name: Recurrent Neoplastic Post-Transplant Lymphoproliferative Disorder

description: The reemergence of neoplastic post-transplant lymphoproliferative disorder after a period of remission.


name: Unresectable Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that is not amenable to surgical resection.


name: Unresectable Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that is not amenable to surgical resection.


description: An epithelioid hemangioendothelioma that is not amenable to surgical resection.


Fallopian Tube Cancer by AJCC v8 Stage

description: A term that refers to the staging of fallopian tube cancer according to the American Joint Committee on Cancer, 8th edition.


name: Adenocarcinoma with spindle cell metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to spindle-shaped cells.


Unresectable Cervical Carcinoma

description: Cervical carcinoma that is not amenable to surgical resection.


name: Squamous cell carcinoma in situ with questionable stromal invasion

description: A malignant epithelial neoplasm involving all the layers of the squamous epithelium, but it is not certain if it is confined to the squamous epithelium or it has invaded the basement membrane and the underlying stroma.


Stage II Uterine Corpus Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Cancer-related Cognitive Dysfunction

description: The effects of cancer and its treatments on cognitive processes.


Prostate cancer stage D

description: Metastatic disease.


Polyp of esophagus

description: A benign intraluminal polypoid neoplasm of the esophagus.  It includes the squamous papilloma and the giant fibrovascular polyp.


name: migraine with or without aura, susceptibility to

description: An inherited susceptibility or predisposition to developing migraines with or without aura.


inherited disease susceptibility

description: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.


disease susceptibility

description: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.