Metastatic Malignant Skin Neoplasm

description: A malignant neoplasm of the skin that has spread to other anatomic sites.


name: Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A rare acute myeloid leukemia that occurs in childhood and is characterized by deletion of chromosome 7.


Stage IB1 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma with equal or more than 5 mm depth of stromal invasion, and less than 2 cm in greatest dimension. (FIGO 2018)


Fibrinogen Deficiency

description: A usually inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


name: Ampulla of Vater Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Disseminated adenocarcinoma

description: Adenocarcinoma that is spread throughout the body.


name: Recurrent Endometrial Squamous Cell Carcinoma

description: The reemergence of endometrial squamous cell carcinoma after a period of remission.


Unresectable Carcinoma

description: Carcinoma that is not amenable to surgical resection.


name: Refractory Metastatic Pancreatic Adenocarcinoma

description: Metastatic pancreatic adenocarcinoma that is resistant to treatment.


name: POLE-Ultramutated Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene that result in an ultra-mutated tumor phenotype.


Cartilaginous hamartoma

description: A hamartoma characterized by the presence of cartilaginous elements.


name: Hodgkin's disease nodular sclerosis stage I supradiaphragmatic


Oligodendroblastoma

description: An obsolete term referring to neoplasms arising from oligodendrocytes.


Disorder of axilla

description: A non-neoplastic or neoplastic disorder that affects the structures of the axilla.  Representative examples include axillary lymphadenitis, axillary lipoma, and metastatic carcinoma to the axillary lymph nodes.


name: Recurrent Abdominal Neuroendocrine Neoplasm

description: The reemergence of an abdominal neuroendocrine neoplasm after a period of remission.


Advanced Sarcoma

description: A sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Recurrent Adenovirus Infection

description: An adenovirus infection that has recurred after a period of remission.


AIDS-Related Retinopathy

description: Retinopathy resulting from AIDS.


Bone marrow hyperplasia

description: Increase in the number of hematopoietic cells in the bone marrow. It may involve all or individual hematopoietic cell lines.


Vitreoretinal Disorder

description: A disorder affecting the vitreous fluid and retina.


Uterine Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the uterine corpus or the cervix. Representative examples include endometritis, uterine adenomyosis, and cervicitis.


name: Acute Myeloid Leukemia with ASXL1 Mutation

description: An acute myeloid leukemia associated with ASXL1 gene mutation.


Delusional disorder, erotomanic type

description: A subtype of delusional disorder characterized by the central delusional theme that another person (usually one of higher status) is in love with the individual.


Stage IV Esophageal Cancer AJCC v6

description: Stage IV includes: Any T, Any N, M1. IVA: Any T, Any N, M1a. IVB: Any T, Any N, M1b.  M1: Distant Metastasis. (AJCC 6th ed.) -2003


name: tubular adenoma of extrahepatic bile duct

description: An adenoma that arises from the extrahepatic bile ducts.  It is characterized by the presence of a tubular pattern.


EBV-Related Malignant Neoplasm

description: A malignant neoplasm that develops in a patient infected with Epstein-Barr virus (EBV) and in which there is a well-documented association between the malignancy and EBV. Representative examples include EBV-related lymphomas and carcinomas.


Uterine Ligament Papillary Cystadenoma

description: A cystadenoma that arises from the broad or other uterine ligaments. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Stage IV Uterine Corpus Cancer

description: Stage IV includes: IVA: (T4, Any N, M0); IVB: (Any T, Any N, M1). T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, or lung, liver, or bone.  It excludes metastasis to para-aortic lymph nodes, vagina, pelvic serosa, or adnexa). This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


neoplasm of optic tract

description: A benign or malignant neoplasm that affects the optic tract.


Sarcomatoid carcinoma of the prostate

description: A rare acinar adenocarcinoma of the prostate gland with unfavorable prognosis. It is composed of both malignant glandular and sarcomatous components. The sarcomatous component contains a malignant spindle cell proliferation or specific mesenchymal elements including osteosarcoma, chondrosarcoma, and leiomyosarcoma.


name: Malignant melanoma in giant pigmented nevus

description: A melanoma arising in a giant congenital melanocytic nevus. The risk of developing a melanoma in a giant congenital melanocytic nevus has been reported to be between 5% and 50%. The incidence of developing melanoma is higher before the age of 10 and in adult life.


Early Disseminated Lyme Disease

description: An early stage of Lyme disease that may present days to weeks after a tick bite with relapsing signs of a red, concentrically-expanding rash (erythema migrans), facial palsy, meningismus, neuralgia, heart palpitations, and dizziness.


Pancreatic Delta Cell Adenoma

description: An endocrine neoplasm arising from the delta cells of the pancreas which produce somatostatin. It does not show evidence of vascular invasion or metastasis to other anatomic sites.


Transfusion hemosiderosis

description: Accumulation of iron in internal organs that results from repeated blood transfusions.


Cervical Adenocarcinoma In Situ

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Microinvasive Malignant Neoplasm

description: A malignant neoplasm that has minimal stromal invasion.


Palsy of accessory nerve

description: Partial or complete paralysis of the spinal accessory nerve.


name: Advanced Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma invading into the bladder muscularis propria.


Neurasthenia

description: An episode of acute, severe anxiety or depression associated with an inability to function as normal.


Non-Neoplastic Retroperitoneal Disorder

description: A non-neoplastic disorder that affects the retroperitoneum.


Adenocarcinoma, metastatic

description: An adenocarcinoma that has spread from its original site of growth to another anatomic site.


Childhood Genitourinary System Neoplasm

description: A neoplasm that affects the genitourinary system during childhood.


Metastatic Glioblastoma

description: Glioblastoma that has spread from its original site of growth to another anatomic site.


Cystic fibrosis pulmonary exacerbation

description: An acute episode of worsening pulmonary symptoms related to cystic fibrosis.


name: Immunodeficiency-Related Central Nervous System Lymphoma

description: A lymphoma that arises from the central nervous system in patients with acquired immunodeficiency conditions or rarely, hereditary immunodeficiency syndromes.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, Tier 2, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the tier 2 Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol.


name: Stage IIA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Ampulla of Vater Gangliocytic Paraganglioma

description: An extra-adrenal paraganglioma that arises from the ampulla of Vater and the periampullary region.  It consists of a mixture of neuroendocrine cells, Schwann-like cells, and ganglion cells.


name: Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2

description: A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with CBFA2T3-GLIS2 chimeric oncogene and has an unfavorable prognosis.


Desmoplastic trichilemmoma

description: A variant of tricholemmoma that is characterized by extensive sclerotic stroma formation.


Localized Malignant Neoplasm

description: A malignant neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


name: Non-Neoplastic Genitourinary System Disorder

description: A non-neoplastic disorder that affects the genitourinary system.


name: Stage IIA Esophageal Adenocarcinoma AJCC v7

description: Stage IIA includes: T2, N0, M0, G3.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. G3: Poorly differentiated.  (AJCC 7th ed.)


Iodine deficiency

description: A deficiency of iodine in the diet.


Stage II Appendix Carcinoma AJCC v8

description: Stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4a: Tumor invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Adenosis

description: Any disease or disorder of a gland, characterized by abnormal development or enlargement of the gland.


name: Metastatic Primary Malignant Central Nervous System Neoplasm

description: A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to other sites.


Mild esophageal dysplasia

description: A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal epithelium.  (WHO, 2000)


name: Prostate Acinar Microcystic Adenocarcinoma

description: Acinar prostate adenocarcinoma characterized by the presence of microcystic foci in radical prostatectomy specimens.


Congenital stenosis of pulmonary artery

description: A congenital cardiovascular abnormality characterized by the narrowing of the lumen of the main pulmonary artery or its branches. It may be associated with other congenital heart malformations. Signs and symptoms include dyspnea, tachypnea, tachycardia, fatigue, and edema.


Radiation-Recall Dermatitis

description: Acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmacologic agent.


name: AIDS-Related Pelvic Inflammatory Disease

description: Pelvic inflammatory disease that develops in a patient with HIV/AIDS.


Stage I Merkel Cell Carcinoma AJCC v7

description: Stage I includes: IA: (T1, pN0, M0) and IB: (T1, cN0, M0).  T1: Primary tumor equal or less than 2 cm in size.  pN0: No regional lymph node metastasis by pathologic examination.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Hidroacanthoma simplex

description: A rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct.


Radiation Fibrosis

description: The formation of scar tissue in the skin and subcutaneous tissues, lungs, genitourinary tract, gastrointestinal tract, and other organs, caused by radiation therapy.


name: Lugano Classification Limited Stage Childhood Hodgkin Lymphoma AJCC v8

description: Limited stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


HPV-related carcinoma

description: A carcinoma associated with the presence of human papillomavirus infection.


name: Gestational Trophoblastic Neoplasm by AJCC v8 Stage

description: A term that refers to the staging of a gestational trophoblastic neoplasm according to the American Joint Committee on Cancer, 8th edition. This classification applies to the following neoplasms: invasive hydatidiform mole, gestational choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Complete and partial hydatidiform moles are not included in this classification. The current FIGO classification includes an anatomic stage designated by Roman numeral I, II, III, or IV, followed by the risk factor score expressed in Arabic numerals (e.g., Stage II: 4, Stage IV: 9).  (from AJCC 8th Ed.)


name: Hodgkin's disease lymphocyte depletion type stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Stage I Gestational Trophoblastic Tumor AJCC v7

description: Stage I includes: (T1, M0, Risk factors: unknown); IA (T1, M0, Risk factors: low risk); IB (T1, M0, Risk factors: high risk).  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIIA Cervical Cancer FIGO 2009

description: Cervical carcinoma involving lower one-third of the vagina. (FIGO 2009)


Stage III Ureter Cancer AJCC v7

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Digestive System Hemangioma

description: A hemangioma arising from any part of the digestive system.


Xeroderma

description: A non-neoplastic disorder characterized by abnormally dry skin.  Causes include vitamin A deficiency, sunlight exposure, medications, metabolic disorders, autoimmune disorders, and hereditary genetic disorders.


name: Malignant Esophageal Neoplasm by Topographic Region

description: Esophageal segments used primarily in pathology, and distinct from the anatomic segments used for clinical purposes.


name: Colorectal Cancer by Astler-Coller Stage


name: Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage II includes: T3, N0, M0. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Acidophil carcinoma

description: A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic dyes.


name: Childhood Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Lymphocyte-depleted classic Hodgkin lymphoma occurring in childhood.


Leukemic infiltration of skin

description: Cutaneous involvement by an acute or chronic leukemia.


Transplant-Related Malignant Neoplasm

description: A malignant neoplasm that arises in a patient with a history of organ transplantation.


name: Clinical Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: (T2, N1, M0); (T3, N0-1, M0); (T4a, N0-1, M0). T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Reproductive System

description: The spread of a malignant neoplasm to the male or female reproductive system from an adjacent or distant anatomic site.


Childhood Hodgkin Lymphoma

description: Hodgkin lymphoma occurring in childhood.


Intracystic Papillary Breast Carcinoma

description: An intraductal breast carcinoma characterized by a papillary growth within a large cystic duct. There is no evidence of invasion of the breast parenchyma.


Metastatic Esophageal Carcinoma

description: A carcinoma that arises from the esophagus and has metastasized to another anatomic site.


Antepartum Obstetric Septic Embolism

description: Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the antepartum period.


name: Unresectable Large Cell Neuroendocrine Carcinoma

description: Large cell neuroendocrine carcinoma that is not amenable to surgical resection.


Extrahepatic Bile Duct Lymphoma

description: A lymphoma that arises from the extrahepatic bile ducts, with the bulk of the disease located at this site.


Stage I Testicular Cancer AJCC v8

description: Stage I includes: pT1-T4, N0, M0, SX. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. pT2: Testicular cancer which is limited to testis (including rete testis invasion) with lymphovascular invasion or invades hilar soft tissue or epididymis or penetrates visceral mesothelial layer covering the external surface of tunica albuginea with or without lymphovascular invasion. pT3: Testicular cancer in which the tumor invades spermatic cord with or without lymphovascular invasion. pT4: Testicular cancer in which the tumor invades scrotum with or without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


name: Myopathy Secondary to Fatty Acid Oxidation Disorder

description: A myopathy that was caused by a primary disorder of fatty acid oxidation.


name: NF1-Associated Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is associated with NF1 gene inactivation and a history of neurofibromatosis type 1.


name: Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Dentophobia

description: A persistent, irrational fear of treatment, whether preventative or therapeutic, by a dentist, coupled with compulsive desire to avoid any such situation.


Stage IIIC Vulvar Cancer AJCC v7

description: Stage IIIC includes: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


Perinatal disorder

description: A non-neoplastic or neoplastic disorder occurring during the period from about five months before birth to one month after birth.


Grade 1 Teratoma

description: A teratoma that contains mature tissue elements and a limited amount of immature tissue elements.


Vaginal Neuroendocrine Carcinoma

description: A rare neuroendocrine carcinoma that arises from the vagina. This category includes small cell and large cell neuroendocrine carcinoma.


name: Pathologic Stage IV Cutaneous Melanoma AJCC v8

description: Stage IV includes: Any T, Tis, Any N, M1. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. M1: Evidence of distant metastasis. (AJCC 8th ed.)


name: Hernia with Obstruction without Mention of Gangrene

description: The protrusion of an organ, or the fascia of an organ, through the wall of the cavity that normally contains it, which results in obstruction, without mention of necrosis of the herniated contents.


name: Stage IIB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of two or more lymph node regions on the same side (either above or below) of the diaphragm or localized involvement of a single extra-lymphatic organ or site in association with regional lymph node involvement (i.e., local extension from a lymph node area into a nearby organ), with or without involvement of other contiguous lymph node regions on the same side (either above or below) of the diaphragm. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Viral gastroenteritis due to Rotavirus

description: Enteritis attributed to the rotavirus.


Atypical adenomatous hyperplasia

description: Proliferation of glandular epithelial cells associated with the presence of cytologic atypia and architectural growth pattern changes.


Rare Non-Neoplastic Disorder

description: A non-neoplastic disorder that is uncommon.


Stage IVC Appendix Carcinoma AJCC v8

description: Stage IVC includes: Any T, Any N, M1c, Any G. M1c: Metastasis to sites other than peritoneum. (AJCC 8th ed.)


name: Recurrent Digestive System Neuroendocrine Neoplasm

description: The reemergence of a digestive system neuroendocrine neoplasm after a period of remission.


description: Rosai-Dorfman-Destombes disease affecting the skin. It manifests with multiple papules, nodules, or plaques.


name: Hypoxic ischemic encephalopathy neonatal

description: Injury to the central nervous system in the newborn period that occurs when there is insufficient delivery of oxygen to all or part of the brain.


Infection-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific infectious agent.


Vaso-Occlusive Crisis

description: An exacerbation of sickle cell disease.


name: Refractory T-Cell Prolymphocytic Leukemia

description: T-cell prolymphocytic leukemia that is resistant to treatment.


Locally Advanced Malignant Neoplasm

description: A malignant neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Mature T-Cell and NK-Cell Neoplasm

description: The reemergence of mature T-cell and NK-cell neoplasm after a period of remission.


Status Migrainosus

description: An episode of migraine that persists for more than 72 hours.


Malignant neoplasm aggravated

description: A malignant neoplasm that shows clinical and/or pathologic progression.


Atrophy of the Uterine Cervix

description: A condition characterized by the absence of squamous maturation in the cervical epithelium. It is associated with decreased estrogen production.


Eccrine Poroma

description: A poroma with eccrine differentiation.


Pelvic abscess

description: An abscess that is located in the pelvic cavity.


name: Endometrial Endometrioid Adenocarcinoma with Papillae


Stage IA1 Cervical Cancer AJCC v8

description: Stage IA1 includes: T1a1, Any N, M0. T1a1: Invasive cervical carcinoma with measured stromal invasion of 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. M0: No distant metastasis. (AJCC 8th Ed.)


Severe Chronic Active EBV Infection

description: A severe form of chronic Epstein-Barr virus infection characterized by continued intermittent fever, lymphadenopathy, thrombocytopenia, lymphocytopenia, neutropenia, polyclonal gammopathy, and greatly elevated titers for antibodies to EBV-related antigens.


name: Metastatic Malignant Genitourinary System Neoplasm

description: A malignant neoplasm that arises from the genitourinary system and has metastasized to other anatomic sites.


Renal pelvis fistula

description: An abnormal communication between the renal pelvis and another anatomic site.


Metastatic Gallbladder Carcinoma

description: A gallbladder carcinoma that has spread from the original site of growth to other anatomic sites.


name: Juvenile Myoclonic Epilepsy, Intractable, without Status Epilepticus

description: Intractable juvenile myoclonic epilepsy which is not associated with an acute, prolonged epileptic crisis.


Adenocarcinoma gastric recurrent

description: The reemergence of gastric adenocarcinoma after a period of remission.


name: Peritoneal Dialysis Catheter-Associated Peritonitis

description: Infection of the peritoneum related to a peritoneal dialysis catheter.


name: Acute on chronic combined systolic and diastolic heart failure

description: Acute decompensation of chronic combined systolic and diastolic congestive heart failure.


Disseminated Listeriosis

description: A bacterial infection by Listeria monocytogenes in two or more non-contiguous sterile body compartments.


name: Superficial Epithelioma with Sebaceous Differentiation

description: A benign epithelial neoplasm occurring in the head, neck or back region. It is characterized by proliferation of basaloid cells in the upper dermis with broad attachments to the epidermis.


Refractory Anaplastic Ganglioglioma

description: Anaplastic ganglioglioma that is resistant to treatment.


name: Primary CD30-Positive T-Cell Lymphoproliferative Disorder

description: A spectrum of T-cell lymphoproliferative disorders that arise from skin, subcutaneous tissue, and head and neck mucosal sites. They are characterized by the presence of CD30-positive neoplastic lymphocytes. Cells that resemble the hallmark cells of anaplastic large cell lymphoma are often seen.


Vaginal Warty Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, hyperkeratosis, and koilocytosis.


name: Infection of peritoneal dialysis catheter

description: A local or systemic infection associated with the use of a peritoneal dialysis catheter.


Stage I Bone Cancer AJCC v8

description: Stage I includes: IA: (T1, N0, M0, G1 or GX); IB: (T2, N0, M0, G1 or GX); (T3, N0, M0, G1 or GX). T1: Tumor measuring 8 cm or less in greatest dimension. T2: Tumor measuring more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G1: Well differentiated, low grade. (AJCC 8th ed.)


name: Human Papillomavirus-Independent Cervical Squamous Cell Carcinoma

description: A cervical squamous cell carcinoma not associated with human papillomavirus infection.


name: p53-Mutant Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the presence of p53 gene mutations.


Tracheal web

description: A rare congenital or acquired abnormality characterized by the presence of a web-like thin layer of tissue that narrows the lumen of the trachea. It may result in wheezing, dyspnea, and respiratory failure.


name: Childhood Pancreatic Acinar Cell Carcinoma

description: An acinar cell carcinoma that arises from the pancreas during childhood.


Gastric hyperplastic polyp

description: A non-neoplastic polyp that arises from the stomach and is characterized by the presence of dilated gastric foveoli, edematous changes, and inflammation.


Metastatic Nested Urothelial Carcinoma

description: Nested urothelial carcinoma that has spread to another anatomic site.


Extrapulmonary Small Cell Carcinoma

description: A small cell neuroendocrine carcinoma that arises from an anatomic site other than the lung.


name: Refractory Male Reproductive System Carcinoma

description: Male reproductive system carcinoma that is resistant to treatment.


Proliferative Inflammatory Atrophy

description: A lesion in the prostate gland characterized by glandular atrophy, chronic inflammation, and epithelial hyperplasia. It has been suggested that it is a precancerous lesion and it may lead to the development of prostatic intraepithelial neoplasia and prostatic carcinoma.


External hemorrhoids (disorder)

description: A hemorrhoid which originates below the dentate line.


Stage III Vulvar Cancer AJCC v7

description: Stage III includes: IIIA: (T1/T2, N1a/N1b, M0); IIIB: (T1/T2, N2a/N2b, M0); IIIC: (T1/T2, N2c, M0).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less.  N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater.  N2c: Vulvar cancer with lymph node metastasis with extracapsular spread.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Gastroesophageal Junction Adenocarcinoma

description: The reemergence of gastroesophageal junction adenocarcinoma after a period of remission.


Hindgut Neuroendocrine Tumor G1

description: A neuroendocrine tumor grade 1 that arises from the sigmoid colon, descending colon, or rectum.


silent stroke

description: An asymptomatic cerebral infarction that was incidentally noted by T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensities on an MRI of the brain.


name: Refractory Acute Myelomonocytic Leukemia

description: Acute myelomonocytic leukemia that does not respond to treatment.


Postpartum Obstetric Septic Embolism

description: Presence of bacterially-infected tissue in the maternal vascular system which originated from a distant site during the postpartum period.


name: Human Papillomavirus-Related Verrucous Carcinoma

description: A verrucous carcinoma that is associated with human papillomavirus infection.


name: Stage IV Acral Lentiginous Melanoma AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


mCode Neoplastic Disease/Finding

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Terminology related to neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Uterine Corpus Cancer by AJCC v6 Stage

description: A term that refers to the staging of uterine corpus cancer according to the American Joint Committee on Cancer, 6th edition.


name: Non-Metastatic Gestational Trophoblastic Tumor

description: Gestational trophoblastic tumor that is confined to the site in which it initially manifested.


Non-Neoplastic Endocrine Disorder

description: A non-neoplastic disorder that affects the endocrine system.  Representative examples include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency.


Uterine Corpus Non-Neoplastic Disorder

description: A non-neoplastic disorder that affects the uterine corpus. Representative examples include endometritis and uterine adenomyosis.


name: Bone Tumor of Undefined Neoplastic Nature

description: A group of lesions that affect the bone and have the appearance and cytogenetic or molecular characteristics of neoplasms but the clinical behavior is suggestive of a non-neoplastic process.


Unresectable Neuroendocrine Tumor G1

description: Neuroendocrine tumor grade 1 that is not amenable to surgical resection.


name: Metastatic Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that has spread from its original site of growth to another anatomic site.


name: Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder

description: A CD30-positive T-cell lymphoproliferative disorder that arises from the skin and is characterized by overlapping morphological features between anaplastic large cell lymphoma and lymphomatoid papulosis.


name: Childhood Acute Promyelocytic Leukemia with PML-RARA

description: An acute promyelocytic leukemia with PML-RARA fusion occurring in children.


Metastatic osteosarcoma

description: An osteosarcoma which has spread to another anatomical site.


Stage IB Cutaneous Melanoma AJCC v7

description: Stage IB includes: (T1b, N0, M0); (T2a, N0, M0).  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Tissue or Organ Disruption

description: A loss of structural integrity within a tissue or organ.


Recurrent Childhood Hodgkin Lymphoma

description: The reemergence of Hodgkin lymphoma after a period of remission during childhood.


Factor V Leiden mutation

description: An abnormality that refers to mutation of factor V Leiden, which is a variant of human factor V. It results in thrombophilia, deep vein thrombosis, and a slightly increased risk of miscarriage.


Refractory Severe Aplastic Anemia

description: Severe aplastic anemia that is resistant to treatment.


name: Stage IIIA Fallopian Tube Cancer AJCC v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis outside the pelvis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Pancreatic Intraductal Tubulopapillary Neoplasm with an Associated Invasive Carcinoma

description: A pancreatic intraductal tubulopapillary neoplasm characterized by the presence of an invasive carcinomatous component.  The invasive carcinoma has a tubular pattern.


Non-Infectious Gastroenterocolitis

description: An inflammatory disease of the stomach and intestines due to a non-infectious cause.


Iris vascular disorder

description: A vascular disorder or the iris.


name: Smooth Muscle Tumor of Uncertain Malignant Potential

description: A neoplasm with smooth muscle differentiation that cannot be reliably diagnosed as benign or malignant because of the presence of ambiguous morphologic findings. The vast majority of cases arise from the female reproductive system. Malignant behavior has been reported in a minority of cases.


Adult Intracranial Meningioma

description: An intracranial meningioma that occurs during adulthood.


Non-Trisomic Autosomal Aneuploidy

description: Autosomal aneuploidy not associated with trisomy. It results in developmental malformations.


name: Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8

description: Stage III includes: IIIA: (T0-2, N1, M0); IIIB: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Non-Neoplastic Vascular Disorder

description: A term that includes all non-neoplastic vascular disorders.


mCode Disease/Finding

description: Terminology related to diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Stage III Childhood Large Cell Lymphoma

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)


name: Postneoadjuvant Therapy Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Pancreatic Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of exocrine and endocrine pancreatic cancer including well-differentiated neuroendocrine tumors according to the American Joint Committee on Cancer, 6th and 7th editions.


Recurrent Childhood Ependymoma

description: The reemergence of ependymoma in childhood after a period of remission.


Childhood Osteoblastoma

description: An osteoblastoma that occurs during childhood.


Refractory Angiosarcoma

description: Angiosarcoma that is resistant to treatment.


Cardiac Mesenchymal Hamartoma

description: A benign soft tissue mass that involves the endocardium, myocardium, or epicardium. It is characterized by the presence of an admixture of mature mesenchymal tissues normally found within the heart.


Resectable Malignant Bone Neoplasm

description: Malignant bone neoplasm that is amenable to surgical resection.


Stage IA Gastric Carcinoma

description: Stage IA includes: T1, N0, M0.  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Biliary Adenofibroma

description: A rare benign neoplasm that arises from the intrahepatic bile ducts.  It is characterized by the presence of biliary epithelial tissue and fibroblastic stroma.


name: Recurrent Acute Leukemia of Ambiguous Lineage

description: The reemergence of acute leukemia of ambiguous lineage after a period of remission.


name: Metastatic Intracranial Malignant Neoplasm

description: An intracranial malignant neoplasm that has spread from its original site of growth to another anatomic site.


Distantly Metastatic Malignant Neoplasm

description: A malignant tumor that has spread from its original (primary) site of growth to another site distant from the primary site.


Iatrogenic Obesity

description: Obesity resulting from medical treatment or intervention.


Immunosuppressive Disorder

description: A disorder in which immune function is suppressed.


Rare Childhood Malignant Neoplasm

description: An infrequent malignant neoplasm that occurs during childhood.


Advanced Biliary Tract Carcinoma

description: Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread extensively to other anatomic sites or is no longer responding to treatment.


FNCLCC Sarcoma Grade 2

description: A sarcoma with a total score of 4 or 5 according to the FNCLCC guidelines.


name: Malignant melanoma in precancerous melanosis

description: A melanoma arising from an atypical intraepithelial melanocytic hyperplasia.


Stage I Esophageal Cancer AJCC v7

description: Stage I includes: For squamous cell carcinoma: IA (T1, N0, M0, G1, GX, Tumor location: Any); IB (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X).  For adenocarcinoma: IA (T1, N0, M0, G1-2, X); IB (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


name: Skin Squamous Cell Carcinoma with Osteoclast-Like Giant Cells

description: A rare squamous cell carcinoma of the skin characterized by the presence of multinucleated non-neoplastic giant cells that resemble osteoclasts.


Stage IA Uterine Corpus Cancer AJCC v7

description: Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to the endometrium or invades less than one-half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


name: Hodgkin's disease mixed cellularity stage IV

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Cronkhite-Canada syndrome

description: Non-neoplastic polyps that arise from the stomach and are often indistinguishable from hyperplastic polyps.  They may be associated with the presence of polyps in other parts of the gastrointestinal tract.  Associated clinical signs and symptoms are nail atrophy, alopecia, and hyperpigmentation.


Early Rheumatoid Arthritis

description: Recent diagnosis of rheumatoid arthritis (usually within one to two years of onset) during which treatment may be more effective and possibly improve the disease course.


Conjunctival Balloon Cell Nevus

description: A balloon cell nevus that arises from the conjunctiva.


name: Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Astler-Coller A Rectal Carcinoma

description: Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.)


Condyloma acuminata of cervix

description: A benign neoplasm that arises from the cervix. It is associated with human papillomavirus infection and is characterized by the presence of papillary structures with fibrovascular cores. The papillary structures are covered with stratified squamous epithelium. Koilocytosis is usually present.


name: Locally Advanced Urethral Urothelial Carcinoma

description: A urethral urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Stage I Bone Sarcoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Bacterial prostatitis

description: An acute or chronic bacterial infection that affects the prostate gland.


name: Stage IIIA2 Fallopian Tube Cancer AJCC v8

description: Stage IIIA2 includes: T3a, N0/N1, M0. T3a: T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Generalized morphea

description: A type of morphea characterized by four or more plaques found in two or more anatomic locations. The plaques are indurated, generally well-delineated, and may include muscle atrophy in affected areas; there is no visceral involvement.


name: T-Cell Proliferation of Uncertain Malignant Potential

description: A T-cell lymphoproliferative disorder with uncertain malignant potential. A representative example is lymphomatoid papulosis.


Sclerosing peritonitis

description: A rare peritoneal cavity disorder that is characterized by the development of dense fibrous tissue in the peritoneum and the creation of severe adhesions in the abdomen that result in partial or complete small bowel obstruction. It may be idiopathic or develop in patients who receive peritoneal dialysis treatment. Patients present with abdominal distention and pain.


Dermal Duct Tumor

description: A poroma characterized by the presence of small nodules of neoplastic cells in the superficial dermis without connection to the epidermis.


Substance-induced psychotic disorder

description: A psychotic disorder characterized by prominent hallucinations or delusions that have been determined to be etiologically linked to substance use, intoxication or withdrawal.


B-Cell Lymphoproliferative Disorder

description: A non-neoplastic or neoplastic proliferation of B-lymphocytes.


Gallbladder Cancer by AJCC v6 Stage

description: A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 6th edition.


Stage IV Gallbladder Cancer AJCC v7

description: Stage IV includes: IVA (T4, N0-1, M0); IVB (Any T, N2, M0); (Any T, Any N, M1).  T4: Tumor invades the main portal vein or hepatic artery, or invades two or more extrahepatic organs or structures.  N0: No regional lymph node metastasis.  N1: Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein. N2: Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.  M0: No distant metastasis.  M1: Distant metastasis. (from AJCC 7th Ed.)


Monogenic Obesity

description: Obesity associated with an identifiable mutation in a single gene.


Fibrocartilaginous mesenchymoma

description: A very rare, locally aggressive neoplasm arising from the bones, usually from the metaphysis of long tubular bones. It is composed of spindle cells, hyaline cartilage nodules, and trabeculae of bone. It may recur locally, but no metastases have been reported.


Stage II Cervical Cancer FIGO 2009

description: Cervical carcinoma invading beyond the uterus but not extending onto the lower third of the vagina or to the pelvic wall. (FIGO 2009)


name: Metastatic Midgut Neuroendocrine Tumor G2

description: A midgut neuroendocrine tumor G2 that has spread from its original site of growth to another anatomic site.


name: Human Papillomavirus-Independent Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma not associated with human papillomavirus infection.


Stage III Gastric Cancer AJCC v6

description: Stage III includes: IIIA (T2a/b, N2, M0); (T3, N1, M0); (T4, N0, M0).  IIIB: (T3, N2, M0).  N0: No regional lymph node metastasis. N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes. T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa. T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. T4: Tumor invades adjacent structures.  M0: No distant metastasis. (AJCC 6th ed.)


Refractory Anal Carcinoma

description: Anal carcinoma that does not respond to treatment.


name: Refractory Malignant Female Reproductive System Neoplasm

description: Malignant female reproductive system neoplasm that is resistant to treatment.


Stage II Gallbladder Cancer AJCC v8

description: Stage II includes: IIA: T2a, N0, M0; IIB: T2b, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Ampullary Noninvasive Papillary Neoplasm, Pancreatobiliary Type

description: An exophytic, preinvasive, papillary epithelial neoplasm that arises from the ampulla of Vater.  Histologically it resembles the papillary neoplasms of the biliary tree.  This category includes neoplasms with low grade dysplasia and high grade dysplasia.


Stage IVA Uterine Corpus Cancer AJCC v7

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invades bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4).  M0: No distant metastasis.  This staging applies to carcinomas and carcinosarcomas. (AJCC 7th ed.)


Drug Resistant Bacterial Infection

description: A bacterial infection that is resistant to antibiotics and antimicrobials.


name: Metastatic Pancreatic Neuroendocrine Carcinoma

description: Pancreatic neuroendocrine carcinoma that has spread from the original site of growth to another anatomic site.


Infective Phlebitis

description: Infection at the site of needle puncture or intravenous catheter placement due to poor aseptic techniques. It is characterized by erythema, pain, swelling, and induration at the catheter insertion site.


Bacterial tracheitis

description: Bacterial infectious process with formation of mucopurulent membranes affecting the trachea. Causative agents include Staphylococcus, Streptococcus, Haemophilus influenzae, Pseudomonas, and Klebsiella.


name: Intermediate Grade Adult Non-Hodgkin's Lymphoma


Atypical Endometriosis

description: A precancerous lesion characterized by the presence of atypical glandular epithelial features in foci of endometriosis. Atypical endometriosis has been observed in contiguity with carcinomas.


name: Stage III Pancreatic Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading adjacent organs (stomach, spleen, colon, adrenal gland) or the wall of large vessels (celiac axis or the superior mesenteric artery). N0: No regional lymph node involvement. N1: Regional lymph node involvement. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Low-CSD Melanoma AJCC v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (from AJCC 6th and 7th Eds.)


name: Microsatellite Stable Endometrial Carcinoma

description: Endometrial carcinoma characterized by the absence of microsatellite instability.


name: Human Papillomavirus-Related Vulvar Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vulva and is caused by human papillomavirus infection.


Non-Neoplastic Eyelid Disorder

description: A non-neoplastic disorder that affects the eyelid.


carcinoma of lacrimal apparatus

description: A carcinoma that arises from the lacrimal gland or the lacrimal drainage system.


name: Acute Myocardial Injury with Right Ventricular Dysfunction Related to COVID-19

description: Acute myocardial injury with evidence of newly reduced right ventricular function in a patient with probable or confirmed acute COVID-19.


name: Prostate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

description: A prostate adenocarcinoma characterized by the presence of cells with eosinophilic cytoplasmic granules that are positive for neuroendocrine markers by immunohistochemistry.


Stage IV Hodgkin Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


Osteolytic Neoplasm

description: A neoplasm that involves bone destruction.


name: Clinical Stage IB Cutaneous Melanoma AJCC v8

description: Stage IB includes: (T1b, N0, M0); (T2a, N0, M0). T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Recurrent Malignant Neoplasm

description: The reemergence of a malignant neoplasm after a period of remission.


name: Childhood Low Grade Myofibroblastic Sarcoma

description: A low-grade myofibroblastic sarcoma that occurs during childhood.


Umbilical Vasculitis

description: A neutrophilic infiltrate arising from fetal vessels of the umbilical cord into the umbilical vessel wall and oriented towards the amniotic cavity.


stage IV pancreatic cancer

description: A carcinoma that arises from the pancreas and has metastasized to another anatomic site.


Deficiency of sulfatase

description: An inherited, progressive neurodegenerative disorder caused by the lack of functional sulfatase leading to the accumulation and deposition of glycosaminoglycans in tissue.


name: Unresectable Paratesticular Malignant Mesothelioma

description: Paratesticular malignant mesothelioma that is not amenable to surgical resection.


Abnormal Laboratory Test Result

description: A laboratory test result that falls outside of the normal, acceptable range.


Dialysis Catheter Exit Site Infection

description: Local infection at the dialysis catheter exit site.


Central Nervous System Carcinoma

description: A malignant tumor arising in the epithelial cells of the brain or spinal cord.


name: Plasma Cell Neoplasm with Associated Paraneoplastic Syndrome

description: A term that refers to rare paraneoplastic syndromes associated with plasma cell neoplasms. This category includes the following: POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes); TEMPI syndrome (telangiectasia, elevated erythropoietin and erythrocytosis, monoclonal gammopathy, perinephric fluid collection, and intrapulmonary shunting); and AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma).


Vaginal cancer recurrent

description: The reemergence of vaginal carcinoma after a period of remission.


signet ring cell carcinoma of appendix

description: An adenocarcinoma arising from the appendix, characterized by the presence of signet-ring, mucin-producing malignant cells.  The signet-ring cells constitute more than fifty-percent of the malignant cells.


Refractory Acute Biphenotypic Leukemia

description: Acute biphenotypic leukemia that is resistant to treatment.


Genital Tract Fistula

description: An abnormal communication between the genital tract and another organ or anatomic structure.


name: Localized Childhood Ependymoma by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Recurrent Primary Myelofibrosis

description: The reemergence of primary myelofibrosis after a period of remission.


name: Borderline Fallopian Tube Mucinous Tumor

description: A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion.


Hyperacute allograft rejection

description: An immediate rejection of transplanted tissue caused by the presence of preformed antibodies to donor human leukocyte antigens.


Mucous Membrane Hemangioma

description: A hemangioma arising from the mucous membranes.


Adenocarcinoma with apocrine metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive transformation of the malignant glandular cells to cells with abundant, usually granular eosinophilic cytoplasm.


name: Stage IB Esophageal Adenocarcinoma AJCC v7

description: Stage IB includes: (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Locally Advanced Paraganglioma

description: A paraganglioma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Childhood Solid Pseudopapillary Neoplasm of the Pancreas

description: A solid pseudopapillary neoplasm of the pancreas occurring during childhood. It is the most frequent pediatric pancreatic tumor. It usually affects adolescent females.


name: Early Stage Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that has not spread beyond the pancreas.


Recurrent Primary Malignant Neoplasm

description: The reemergence of a primary malignant neoplasm after a period of remission.


regressing melanoma of skin

description: Cutaneous melanoma characterized by the disappearance of the melanoma cells from the primary tumor.


name: Refractory Metastatic Digestive System Carcinoma

description: A digestive system carcinoma that has metastasized to another anatomic site and is resistant to treatment.


Lymphoepithelial tumor of skin

description: A rare, poorly differentiated squamous cell carcinoma of the skin. It is characterized by the presence of tumor cells islands surrounded and infiltrated by lymphocytes and plasma cells.


name: Advanced Primary Malignant Central Nervous System Neoplasm

description: A malignant neoplasm that arises from the central nervous system and has spread extensively to other anatomic sites or is no longer responding to treatment.


Sternal Disorder

description: A non-neoplastic or neoplastic disorder that affects the sternum.


Stage II Bone Cancer AJCC v8

description: Stage II includes: IIA: (T1, N0, M0, G2 or G3); IIB: (T2, N0, M0, G2 or G3). T1: Tumor measuring 8 cm or less in greatest dimension. T2: Tumor measuring more than 8 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G2: Moderately differentiated, high grade. G3: Poorly differentiated, high grade. (AJCC 8th ed.)


name: Pathologic Stage II Merkel Cell Carcinoma AJCC v8

description: Stage II includes: IIA: (T2-3, N0, M0); IIB: (T4, N0, M0). T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Refractory Human Papillomavirus-Related Malignant Neoplasm

description: Human papillomavirus-related malignant neoplasm that does not respond to treatment.


description: Inflammation of the stomach that is associated with Helicobacter Pylori.


Uterine Corpus Cancer by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to uterine corpus sarcomas: leiomyosarcomas, endometrial stromal sarcomas, and adenosarcomas. These sarcomas are staged according to the classification for uterine corpus sarcomas. (from AJCC 8th Ed.)


Adult Pure Erythroid Leukemia

description: A pure erythroid leukemia occurring in adults.


Endometrioid carcinoma of prostate

description: A usually aggressive invasive adenocarcinoma of the prostate gland composed of large glands containing tall columnar cells.  The columnar cells have abundant cytoplasm and are reminiscent of endometrial carcinoma.  This type of adenocarcinoma has a tendency to metastasize to the lung and penis.


Stage IVA Bladder Cancer AJCC v8

description: Stage IVA includes: (T4b, N0, M0); (Any T, Any N, M1a). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. (AJCC 8th ed.)


Uterine Fistula

description: An abnormal communication between the uterus and another organ.


name: Metastatic malignant neoplasm to urinary system

description: The spread of a malignant neoplasm to the urinary system from an adjacent or distant anatomic site.


Nevus spider congenital

description: A type of telangiectasia, comprised of a central red spot with radiating, red extensions, that is present at the time of birth.


Fetal Diseases

description: A non-neoplastic or neoplastic disorder which occurs in the fetus.


name: Lugano Classification Adult Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for adult Hodgkin lymphomas based on the Lugano classification criteria. Staging for adult Hodgkin lymphoma is the same as for the childhood counterpart. (from AJCC 8th Ed.)


Osteoclast-Rich Osteopetrosis

description: A form of osteopetrosis in which osteoclasts are abundant but have severely impaired resorptive function.


name: Stage II Renal Pelvis and Ureter Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic malignant neoplasm to pancreas

description: A malignant neoplasm that has spread to the pancreas from another anatomic site.  Representative examples include metastatic carcinomas from the gastrointestinal tract, metastatic melanomas, and renal cell carcinomas.


Recurrent Fallopian Tube Adenocarcinoma

description: The reemergence of fallopian tube adenocarcinoma after a period of remission.


Neuroendocrine Tumor G3

description: A well-differentiated, high-grade epithelial neoplasm with neuroendocrine differentiation. It usually arises from the digestive system.


Gum Infection

description: An acute or chronic infectious process affecting the gums.


name: Inflammatory fibroepithelial hyperplasia of oral mucous membrane caused by denture

description: A benign fibrous hyperplasia in the oral mucosa caused by the prolonged wear of ill-fitting denture.


Amegakaryocytosis

description: A non-neoplastic, congenital or non-congenital disorder charcaterized by marked reduction or absence of megakaryocytes and thrombocytopenia.


name: Metastatic Plasmacytoid Urothelial Carcinoma

description: Plasmacytoid urothelial carcinoma that has spread to another anatomic site.


name: Lugano Classification Stage II Adult Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: Lacrimal Gland Epithelial-Myoepithelial Carcinoma

description: A rare, slow-growing carcinoma that arises from the lacrimal gland. It is characterized by the presence of duct-like structures lined by two layers of cells, an inner layer composed of epithelial-type cells and an outer layer composed of clear, myoepithelial-type cells.


name: FIGO Stage IA Gestational Trophoblastic Tumor


name: Testicular Neuroendocrine Tumor, Prepubertal-Type

description: A rare, usually well-differentiated neuroendocrine neoplasm that arises from the testis. It usually affects adults, and a minority of patients have carcinoid syndrome. It may occur in isolation or, less frequently, be associated with testicular teratoma. The majority of cases are not associated with isochromosome 12p or germ cell neoplasia in situ. The clinical course is usually benign.


name: Adult Pre-B Acute Lymphoblastic Leukemia

description: Pre-B acute lymphoblastic leukemia that occurs during adulthood.


description: Dedifferentiated liposarcoma that is not amenable to surgical resection.


Stage IVA Vulvar Cancer AJCC v6

description: Stage IVA includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0).  N2: Bilateral regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage IV Cervical Cancer FIGO 2009

description: Cervical carcinoma involving adjacent and distant organs. (FIGO 2009)


Secondary hemochromatosis

description: Hemochromatosis that is not inherited and is caused by iron overload from excessive consumption, multiple transfusions, or disorders of erythropoiesis.


Astler-Coller C1 Rectal Carcinoma

description: Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


name: Stage IIIA Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIIA includes: T4, N0, M0.  T4: Stomach/duodenum/ampulla/jejunum/ileum: tumor invades visceral peritoneum (serosa) or invades other organs or adjacent structures; colon or rectum: tumor invades peritoneum or other organs.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Cataract associated with radiation

description: A cataract resulting from exposure to radiation.


Intermediary Metabolism Disorder

description: An inborn metabolic disorder affecting the intermediary metabolism process. It results in accumulation of substances in the body that can cause acute or chronic intoxication.


Dyskinesia with Orofacial Involvement

description: A genetic condition associated with mutation(s) in the ADCY5 gene, encoding adenylate cyclase 5. It is characterized by abnormal involuntary movements with orofacial involvement.


Childhood Pilomyxoid Astrocytoma

description: A pilomyxoid astrocytoma that occurs during childhood.


Advanced Hodgkin Lymphoma

description: Hodgkin lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Non-Neoplastic Peritoneal and Retroperitoneal Disorder

description: A non-neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Fetal Chorionic Vasculitis

description: A neutrophilic infiltrate arising from fetal vessels in the chorionic plate and oriented towards the amniotic cavity.


Zinc deficiency

description: A genetic or acquired metabolic disorder that is associated with zinc deficiency in the tissues.


Merkel Cell Carcinoma by AJCC v8 Stage

description: A term that refers to the staging of Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma), following the rules of the TNM AJCC v8 classification system.


name: Refractory Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that does not respond to treatment.


Gallbladder Infection

description: An acute or chronic infectious process affecting the gallbladder.


name: Hereditary Malignant Urinary System Neoplasm

description: A malignant urinary system neoplasm that has developed in relatives of patients with a history of malignant urinary system neoplasm.


Neoplasm of musculoskeletal system

description: A benign, intermediate, or malignant neoplasm that affects muscles and bones.


name: Low Grade Broad Ligament Serous Adenocarcinoma

description: A slow-growing serous adenocarcinoma that arises from the broad ligament. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


Syringocystadenocarcinoma papilliferum

description: A sweat gland carcinoma usually arising from a pre-existing syringocystadenoma papilliferum.


name: Acute Myeloid Leukemia with Monoallelic CEBPA Mutation

description: An acute myeloid leukemia with single mutations of the CEBPA gene.


Stage IB Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth. (FIGO 2009)


name: Locally Advanced Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to nearby tissues or lymph nodes.


name: Locally Advanced Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma that has spread to nearby tissues or lymph nodes.


name: Adenocarcinoma with neuroendocrine differentiation

description: An invasive adenocarcinoma characterized by the presence of focal or extensive neuroendocrine differentiation.


Cutaneous Langerhans cell histiocytosis

description: Langerhans cell histiocytosis that affects the skin. It manifests with skin papules and plaques.


Hutchinson's Melanotic Freckle

description: An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, without infiltration of the papillary or reticular dermis. The melanocytic proliferation is associated with actinic damage and epidermal atrophy.  It usually occurs in the sun-exposed skin of elderly people.  It is a form of melanoma in situ.


Malignant neoplasm of stomach stage I

description: Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0); (T1, N1, M0).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes. M0: No distant metastasis. (AJCC 7th ed.)


Stage I Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


Breast Adenolipoma

description: A breast hamartoma characterized by the presence of adipose tissue that contains entrapped glands.


name: Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1, Any G. M1: Distant metastasis. (AJCC 8th ed.)


name: Adult Acute Myeloid Leukemia with Maturation

description: An acute myeloid leukemia with maturation occurring in adults.


Tertiary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that results from progression of secondary hyperparathyroidism in which the parathyroid glands secrete parathyroid hormone autonomously, despite the presence of elevated parathyroid hormone and calcium levels in the serum.


Adult Oligodendroglial Tumor

description: An oligodendroglial tumor of the central nervous system occurring in adults.


Recurrent Myelofibrosis

description: The reemergence of myelofibrosis after a period of remission.


Metastatic Mesonephric Adenocarcinoma

description: Mesonephric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Genitourinary System Carcinoma

description: A genitourinary system carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Post-kala-azar dermal leishmaniasis

description: A cutaneous form of leishmaniasis which sometimes occurs after visceral leishmaniasis treatment.  It is characterized by hypo-pigmented macules, papules, plaques, nodules, or facial erythema; and is considered to be a durable infection reservoir for visceral leishmaniasis.


Vulvar Cancer by AJCC v8 Stage

description: A term that refers to the staging of vulvar cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all carcinomas of the vulva. Melanoma of the vulva is staged according to the classification for melanoma of the skin. (AJCC 8th Ed.)


IgA Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgA monoclonal immunoglobulin in the blood or urine.


name: Digestive System Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The Ki-67 index is higher than 20%.


Foregut Neuroendocrine Tumor G1

description: A neuroendocrine tumor grade 1 that arises from the esophagus, stomach, or duodenum.


Low lying placenta

description: A condition in which the placental edge is within 2 cm of but not covering the cervical os.


Refractory Prostate Adenocarcinoma

description: Prostate adenocarcinoma that is resistant to treatment.


Childhood Mullerian Papilloma

description: Mullerian papilloma that occurs during childhood.


name: Metastatic Gastroesophageal Junction Adenocarcinoma

description: Gastroesophageal junction adenocarcinoma which has spread from its original site of growth to another anatomic site.


Non dystrophic myotonia

description: A group of rare skeletal muscle ion-channel disorders caused by genetic mutations in the sodium and chloride channel genes. It is characterized by altered membrane excitability resulting in skeletal muscle stiffness. This group of myotonias is distinct from myotonic dystrophy because of the absence of systemic features or progressive weakness.


Traditional Serrated Adenoma

description: An adenoma that arises from the large intestine and the appendix.  It is characterized by prominent serration of the glands.


name: Acute on chronic graft-versus-host disease

description: Sudden decompensation of chronic graft versus host disease.


Gallbladder Neuroendocrine Tumor G1

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the gallbladder. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Secondary malignant neoplasm of vulva

description: A malignant neoplasm that has spread to the vulva from another anatomic site.


Stage IA Merkel Cell Carcinoma AJCC v7

description: Stage IA includes: T1, pN0, M0.  T1: Primary tumor equal or less than 2 cm in size.  pN0: No regional lymph node metastasis by pathologic examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Borderline Exocrine Pancreatic Neoplasm

description: A group of epithelial neoplasms that arise from the exocrine pancreatic tissue and have the potential to evolve into invasive malignant neoplasms.  This group includes the pancreatic intraepithelial neoplasias, non-invasive pancreatic mucinous-cystic neoplasms, pancreatic intraductal papillary-mucinous neoplasms, and pancreatic intraductal tubulopapillary neoplasms.


name: Metastatic Anal Canal Squamous Cell Carcinoma

description: Anal canal squamous cell carcinoma that has spread from its original site of growth to another anatomic site.


S-Beta Thalassemia

description: A disorder characterized by the body's inability to synthesize beta-globin chains, leading to the formation of abnormal hemoglobin and anemia. This inherited autosomal recessive blood disorder is caused by germline mutation of the HBB gene.


name: Adult Acute Myeloid Leukemia with t(16;16)(p13.1;q22); CBFB-MYH11

description: An acute myeloid leukemia with t(16;16)(p13.1;q22); CBFB-MYH11 occurring in adults.


Stage IV Bone Cancer AJCC v8

description: Stage IV includes: IVA: (Any T, N0, M1a, Any G); IVB: (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1a: Metastasis in the lung. M1b: Metastasis in the bone or other distant sites. (AJCC 8th ed.)


name: Stage IA Pancreatic Cancer AJCC v6 and v7

description: Stage IA includes: T1, N0, M0. T1: Tumor limited to the pancreas, 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Recurrent Endometrial Mixed Cell Adenocarcinoma

description: The reemergence of endometrial mixed cell adenocarcinoma after a period of remission.


name: Refractory Malignant Nongerminomatous Germ Cell Tumor

description: Malignant nongerminomatous germ cell tumor that is resistant to treatment.


Carcinoma in situ of ampulla of Vater

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Poorly Differentiated Fibrosarcoma

description: A usually aggressive malignant neoplasm arising from the deep soft tissue.  It is characterized by the presence of poorly-differentiated spindle-shaped fibroblasts, collagenous stroma formation and increased mitotic activity.


Urethral Condyloma Acuminatum

description: A sexually transmitted papillary neoplasm that arises from the epithelial surface of the urethra, and caused by the human papillomavirus.


Acquired Factor I Deficiency

description: An acquired coagulation disorder characterized by the partial or complete absence of fibrinogen (factor I) activity in the blood.


Musculoskeletal Deformity

description: Congenital or acquired deformity of the musculoskeletal system.


Compound Spitz Nevus

description: A Spitz nevus characterized by the presence of both junctional and dermal melanocytic components.


Esophageal Cancer by AJCC v6 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 6th edition.


Well Differentiated Fibrosarcoma

description: A well-differentiated malignant neoplasm arising from the deep soft tissues.  It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern.


Diplegia

description: Paralysis affecting corresponding parts on both sides of the body.


Refractory Endometrial Adenocarcinoma

description: Endometrial adenocarcinoma that is resistant to treatment.


Luminal B Prostate Carcinoma

description: Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a higher proliferation score than the luminal A prostate carcinoma. Patients with luminal B prostate carcinoma have the poorest prognosis but respond better to postoperative androgen deprivation therapy compared to patients with non-luminal B prostate carcinoma.


Toxic methemoglobinemia with cyanosis

description: Blue skin coloration due to elevated blood levels of methemoglobin. The degree of cyanosis is directly correlated to the concentration of methemoglobin in the blood. As methemoglobin is not suitable for carrying oxygen, hypoxemia becomes a serious sequela.


name: Metastatic Malignant Pancreatic Neoplasm

description: A malignant neoplasm that arises from the pancreas and has metastasized to another anatomic site.


Pancreatic adenocarcinoma recurrent

description: The reemergence of pancreatic adenocarcinoma after a period of remission.


Peritoneal and Retroperitoneal Neoplasm

description: A benign or malignant, primary or metastatic neoplasm that affects the peritoneum and/or retroperitoneum.


name: Hodgkin's disease nodular sclerosis stage I subdiaphragmatic


name: acute myeloid leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2)

description: An acute myeloid leukemia associated with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) resulting in the reposition of a distal GATA2 enhancer to activate MECOM expression. It may present de novo or follow a myelodysplastic syndrome. The clinical course is aggressive.


name: Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Psoriatic Juvenile Idiopathic Arthritis

description: A category of juvenile idiopathic arthritis defined by the presence of arthritis with a personal or family history of psoriasis, and features such as dactylitis and nail dystrophy.


Hepatic Thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the veins in the liver or hepatic artery.


Non-Neoplastic Soft Tissue Disorder

description: A non-neoplastic disorder that affects the soft tissue.


Hyperplasia of pituitary gland

description: A rare condition characterized by hyperplasia and hypertrophy of the pituitary gland. It is caused by hypersecretion of hypothalamic stimulating hormones.


Recurrent Malignant Skin Neoplasm

description: Reemergence of a malignant skin neoplasm after a period of remission.


Recurrent Malignant Scrotal Neoplasm

description: The reemergence of a malignant scrotal neoplasm after a period of remission.


name: Metastatic malignant neoplasm to esophagus

description: A malignant neoplasm that has spread to the esophagus from another organ or system, or from another primary esophageal tumor. The primary esophageal tumor is not in continuity with the metastatic lesion. Representative examples of metastatic cancers to the esophagus include breast and lung metastatic carcinomas and melanomas.


Adenomatosis, Pulmonary

description: This is a non-human neoplastic process described in sheep.


cell-associated neurotoxicity

description: Neurotoxicity associated with immune effector cell therapy. It may be characterized by aphasia, altered level of consciousness, motor weakness, seizures, and cerebral edema.


Recurrent Visual Pathway Glioma

description: The reemergence of visual pathway glioma after a period of remission.


name: Acute Myeloid Leukemia with ZRSR2 Mutation

description: An acute myeloid leukemia associated with ZRSR2 gene mutation.


Stage IIIB Prostate Cancer AJCC v8

description: Stage IIIB includes: T3-4, N0, M0, PSA: Any, Grade Group 1-4; T3: Prostate cancer with extraprostatic tumor that is not fixed or does not invade adjacent structures. T4: Prostate cancer in which the tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Locally Advanced Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Cutaneous T Lymphoblastic Leukemia/Lymphoma

description: T-lymphoblastic leukemia/lymphoma that affects the skin.


name: Recurrent Endometrial Mucinous Adenocarcinoma

description: The reemergence of endometrial mucinous adenocarcinoma after a period of remission.


name: Invasive Pancreatic Micropapillary Adenocarcinoma

description: An invasive pancreatic ductal adenocarcinoma characterized by the presence of clusters of malignant cells located within artifactual clear stromal spaces.


Subphrenic Abscess

description: An abscess that is located in the anatomical space between the diaphragm and the liver and/or spleen.


name: Acute Myeloid Leukemia with MECOM Rearrangement

description: Acute myeloid leukemia characterized by rearrangement of the MECOM gene with various genes.


Stage III Cervical Cancer FIGO 2009

description: Cervical carcinoma involving lower vagina, pelvic sidewall, and ureters. (FIGO 2009)


Insomnia exacerbated

description: Insomnia that is made worse by other factors, including pain, physiological or psychological disorders, external causes, or pharmacologic interventions.


name: Recurrent Digestive System Neuroendocrine Carcinoma

description: The reemergence of a neuroendocrine carcinoma in any part of the digestive system after a period of remission.


name: Clonal Cytopenia of Undetermined Significance

description: Clinically meaningful cytopenia in one or more hematopoietic cell lineages. Clonal hematopoiesis is present with the variant allele frequency (VAF) equal or more that 2 percent. There is no other evidence of hematologic malignancy.


Stage IB2 Cervical Cancer AJCC v9

description: Stage IB2 includes: T1b2, N0, M0. T1b2: Tumor measuring more than 2 cm and equal or less than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Chronic combined systolic and diastolic heart failure

description: Chronic heart failure due to reduced contractility of the left ventricle and which does not fill properly due to decreased compliance.


name: Locally Advanced Appendix Adenocarcinoma

description: Appendix adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Refractory HIV-Related Lymphoproliferative Disorder

description: HIV-associated lymphoproliferative disorder that is resistant to treatment.


Refractory Barrett Esophagus

description: Dysplasia in Barrett esophagus that is resistant to treatment.


Advanced Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has metastasized from its original site of growth to distal anatomic sites or is no longer responding to treatment.


Intermediate Osteogenic Neoplasm

description: A non-metastasizing, locally aggressive, bone-forming neoplasm.


Paratesticular Epithelial Neoplasm

description: A benign, borderline, or malignant epithelial neoplasm that arises from the paratesticular structures.


Dialysis dementia

description: A severe, often fatal encephalopathy which has been attributed to accumulation in the brain of aluminum from dialysate prepared with inadequately purified water.


name: Malignant Lymphoma, Large Cell, Cleaved and Non-Cleaved

description: Antiquated term describing follicular (nodular) or diffuse non-Hodgkin lymphomas that are composed of a mixture of large cells: large cleaved cells, with irregular nuclei without visible nucleoli; and large non-cleaved cells (centroblasts), having a rounder nucleus with two to three small, peripherally placed nucleoli and a small amount of basophilic cytoplasm.  The follicular variants represent mature B-cell lymphomas, whereas the diffuse variants can be either mature B- or mature T-cell lymphomas.


Acute hemorrhagic edema of infancy

description: A self-limiting cutaneous vasculitis that typically presents as a clinical triad of purpura, edema, and fever in children between the ages of four months and two years old. It is usually associated with a recent history of upper respiratory infection and/or antibiotic therapy.


description: A reactive cutaneous proliferation of macrophages associated with local trauma. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents as a single, asymptomatic, cutaneous or mucosal, firm xanthomatous to dark-red papule or nodule. (WHO 2018)


Low grade myofibroblastic sarcoma

description: A low-grade malignant neoplasm arising from the soft tissue and rarely bone. It is characterized by the presence of spindle-shaped myofibroblasts and collagenous stroma formation in a storiform growth pattern. Metastasis is very rare.


Cutaneous Precursor Lymphoid Neoplasm

description: A precursor lymphoid neoplasm that affects the skin.


Stage IIIA Cervical Cancer AJCC v9

description: Stage IIIA includes: T3a, N0, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Adult Erythroleukemia

description: An erythroleukemia occurring in adults.


Lymphangioma of liver

description: A rare lymphangioma that arises from the liver.  It usually occurs in children and adolescents.


name: Metastatic Childhood Astrocytoma by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage y-II Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, International Society of Pediatric Oncology (SIOP) Protocol

description: Tumor extends beyond kidney but completely resected. Tumor penetrates renal capsule into perirenal fat. Tumor infiltrates the renal sinus and/or invades blood and lymphatic vessels outside renal parenchyma but is completely resected. Tumor infiltrates adjacent organs or vena cava but is completely resected. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Metastatic sarcoma

description: A sarcoma that has spread from its original site of growth to another anatomic site.


name: Stage IIIB Ampulla of Vater Cancer AJCC v8

description: Stage IIIB includes: (T4, Any N, M0); (Any T, N2, M0). T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, irrespective of size. N2: Metastasis to four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring equal or less than 3 mm in depth. (FIGO 2009)


Unresectable Liposarcoma

description: A liposarcoma which is not amenable to surgical resection.


name: Stage II Ampulla of Vater Cancer AJCC v7

description: Stage II includes: IIA (T3, N0, M0); IIB (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the pancreas.  T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades the duodenal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Teratoma with Endocrine Differentiation

description: A teratoma that arises outside an endocrine organ and shows endocrine differentiation. The endocrine component ranges from benign endocrine tissue to malignant endocrine neoplasms. This category includes struma ovarii, thyroid carcinoma arising in struma ovarii, and carcinoid tumor arising in ovarian teratoma.


name: T-Cell Prolymphocytic Leukemia, Small Cell Variant

description: A T-cell prolymphocytic leukemia characterized by the presence of small neoplastic prolymphocytes often with invisible nucleolus by light microscopy.


Advanced Anal Carcinoma

description: Anal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Refractory Myeloproliferative Neoplasm

description: A myeloproliferative neoplasm that does not respond to treatment.


name: IgM-Positive Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: A primary cutaneous marginal zone lymphoproliferative disorder characterized by expression of IgM and absence of class-switched immunoglobulin heavy chain expression.


Immune Dysregulation Disorder

description: A group of autoimmune disorders characterized by defects in self-tolerance (central or peripheral) resulting in autoimmune disease with or without recurrent infections, comprised by: Familial hemophagocytic lymphohistiocytosis (FHL) syndromes; FHL syndromes with hypopigmentation; Regulatory T cell (Treg) defects (eg, IPEX); Autoimmunity with or without lymphoproliferation (eg, autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy [APECED]); Autoimmune lymphoproliferative syndrome (ALPS); Immune dysregulation with colitis; and Susceptibility to Epstein-Barr virus (EBV) and lymphoproliferative conditions.


Stage III Pancreatic Cancer AJCC v8

description: Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. T4: Tumor involving the celiac axis, superior mesenteric artery, and/or common hepatic artery, regardless of size. N2: Metastasis in four or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage I Childhood Hodgkin Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Frontal Lobe Anaplastic Oligodendroglioma

description: An anaplastic oligodendroglioma occurring in the frontal lobe.


name: Ann Arbor Stage II Supradiaphragmatic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the superior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript.


description: A non-invasive neoplastic process that affects the epithelium of any part of the digestive system.  It is characterized by the presence of morphologic features of dysplasia (e.g., architectural and cytological epithelial alterations) or, in a minority of cases, lack of such morphologic features, as in colonic sessile serrated adenomas/polyps.


name: Prostatic Atypical Adenomatous Hyperplasia

description: A prostatic hyperplasia characterized by the presence of crowded adenomatous epithelial nodules.


name: Genitourinary malfunction arising from mental factors

description: A dysfunction in genitourinary function that is due to a psychological process.


Mixed acinar-ductal carcinoma

description: A carcinoma that arises from the pancreas showing either extensive mucin accumulation and acinar neoplastic cells or a mixture of columnar or signet-ring cells and acinar neoplastic cells.


Erythema toxicum neonatorum

description: A benign, self-limited eruption of vesicles, pustules, papules and macules seen in newborns. An eosinophilic infiltrate can be isolated suggesting an immune-mediated reaction in the skin.


Gastric Adenoma, Gastric-Type

description: A neoplastic polyp that arises from the stomach.  It is characterized by the presence of gastric epithelial differentiation.  It includes pyloric gland adenomas and foveolar-type adenomas.


Tourettism

description: Tics that are secondary to an identifiable cause.


Periorbital Infection

description: An infectious process affecting the tissues around the orbit.


Gallbladder Cancer by AJCC v7 Stage

description: A term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 7th edition.


Pulmonary Fistula

description: An abnormal communication between the lung and another organ or anatomic site.


Stage IV Uterine Corpus Cancer AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus carcinoma or carcinosarcoma with tumor invading the bladder mucosa and/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (includes metastasis to inguinal lymph nodes, intraperitoneal disease, lung, liver, or bone. It excludes metastasis to pelvic or para-aortic lymph nodes, vagina, uterine serosa, or adnexa). (from AJCC 8th Ed.)


Localized Sarcoma

description: A sarcoma that is confined to a specific site without evidence of spread to other anatomic sites.


name: Recurrent Human Papillomavirus-Related Malignant Neoplasm

description: The reemergence of human papillomavirus-related malignant neoplasm after a period of remission.


name: Acute Myeloid Leukemia with TBL1XR1-RARA

description: Acute myeloid leukemia with variant RARA rearrangement and expression of TBL1XR1-RARA fusion protein.


name: Stage IIB Gestational Trophoblastic Tumor AJCC v7

description: Stage IIB includes: T2, M0, Risk factors: high risk.  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Drug-induced gingival hyperplasia

description: Overgrowth of the gingival tissue caused by phenytoin, cyclosporine A, and calcium channel blockers.


Stage IB Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma with measured deepest invasion equal or more than 5 mm (greater than Stage IA), lesion limited to the cervix uteri. (FIGO 2018)


name: Acute Myocardial Injury with Cardiogenic Shock Related to COVID-19

description: Acute myocardial injury with evidence of cardiogenic shock defined as clinical evidence of low cardiac index (e.g., less than 2.2 L/min/m2) accompanied by impaired tissue perfusion in a patient with probable or confirmed acute COVID-19.


Recurrent Lymphoma

description: The reemergence of a lymphoma after a period of remission.


name: Stage IV Fallopian Tube Cancer AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes metastasis within the peritoneal cavity). (AJCC 6th and 7th eds.)


Stage IVA Bone Cancer AJCC v7

description: Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Neoplasms, Unknown Primary

description: The spread of a malignant neoplasm from an unknown primary to another region remote from the primary site.