Biliary Tract Carcinoma

description: A carcinoma arising from the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, or gallbladder.


Pancreatic Teratoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A teratoma that arises from the pancreas.


Tobacco Induced Hyperparakeratosis

description: Hyperparakeratosis of the oral mucosa caused by chronic tobacco use.  It manifests as oral leukoplakia.


name: Locally Advanced Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: COL1A1 Associated Connective Tissue Disorder

description: A group of connective tissue disorder caused by mutations in the COL1A1 gene mapped to chromosome 17q21. It includes the Ehlers-Danlos syndrome, osteogenesis imperfecta, and osteoporosis.


Stage 0 Esophageal Cancer AJCC v6

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.)


Splenic Infection

description: An infectious process affecting the spleen. Predisposing factors include immunosuppression, diabetes mellitus, and sickle cell anemia. Infectious agents include bacteria (e.g., staphylococcus and streptococcus) and fungi.


name: High Grade Corneal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the corneal epithelium.


description: An endometrial carcinoma that has a documented response to platinum-based chemotherapy.


Skin Verrucous Carcinoma

description: A verrucous carcinoma that arises from the skin. It usually affects the palms, soles, and distal digits.


Glucose-6-Phosphatase 3 Deficiency

description: An autosomal recessive inherited disorder caused by mutations in the G6PC3 gene. It is characterized by the absence or presence of very low levels of glucose-6-phosphatase 3. Patients may develop severe congenital neutropenia.


name: Conventional Follicular Dendritic Cell Sarcoma

description: Follicular dendritic cell sarcoma that is not associated with Epstein-Barr virus.


Breast fibroadenolipoma

description: A benign, circumscribed and usually encapsulated lesion of the breast.  It contains all the components of the breast tissue.


name: Unresectable Primary Central Nervous System Neoplasm

description: A primary central nervous system neoplasm that is not amenable to surgical resection.


Prostate Intraductal Carcinoma

description: An intra-acinar and/or intraductal neoplastic epithelial proliferation in the prostate gland that has some features of high-grade prostatic intraepithelial neoplasia but exhibits much greater architectural and/or cytological atypia, typically associated with high-grade, high-stage prostate carcinoma. (WHO 2016)


Resectable Osteosarcoma

description: Osteosarcoma that is amenable to surgical resection.


name: Ionizing Radiation-Related Malignant Neoplasm

description: A malignant neoplasm arising in an anatomic site exposed to ionizing radiation.


Fascial fibrosarcoma

description: A malignant fibroblastic neoplasm arising from the fascial connective tissue.


name: Transplant-Related Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that arises in a patient with a history of organ transplantation.


Traumatic injury

description: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.


Vaginal Basaloid Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of nests of malignant basaloid squamous cells with scant amounts of cytoplasm.


name: Ventral Hernia with Obstruction without Mention of Gangrene

description: The protrusion of contents of the abdominal cavity through the abdominal wall, at the site of the linea alba, which results in obstruction, without mention of necrosis of the herniated contents.


name: Autosomal Dominant Neurohypophyseal Diabetes Insipidus

description: An autosomal dominant form of diabetes insipidus caused by mutation(s) in the AVP gene encoding arginine vasopressin.


Advanced Bone Sarcoma

description: A bone sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Lipid-Rich Urothelial Carcinoma

description: Lipid-rich urothelial carcinoma that has spread to another anatomic site.


Stage IV Fallopian Tube Cancer AJCC v8

description: Stage IV includes: Any T, Any N, M1: M1: Distant metastasis, including pleural effusion with positive cytology; liver or splenic parenchymal metastasis; metastasis to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); and transmural involvement of intestine. (from AJCC 8th Ed.)


name: Recurrent Vulvar Squamous Cell Carcinoma

description: The reemergence of vulvar squamous cell carcinoma after a period of remission.


Metastatic Anal Carcinoma

description: Anal carcinoma that has spread from its primary site to another anatomic site.


name: Undifferentiated Fallopian Tube Carcinoma

description: An invasive carcinoma arising from the fallopian tube. It is characterized by the presence of a diffuse malignant infiltrate that is composed of epithelial cells without evidence of glandular or squamous differentiation.


Transfusion dependent thalassaemia

description: Thalassemia that results in severe anemia and requires regular blood transfusions for patient survival.


name: Metastatic malignant neoplasm to nervous system

description: The spread of a malignant neoplasm to the nervous system.  This may be from a primary nervous system malignant neoplasm, or from a malignant neoplasm at a distant site.


name: Stage III Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: large cell neuroendocrine carcinoma of anal canal

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal.  It is characterized by the presence of malignant large cells.


Appendix Mucinous Neoplasm

description: An appendiceal neoplasm characterized by mucinous epithelial proliferation with extracellular mucin and pushing tumour margins. (WHO 2019)


Primary Immune Regulatory Disorder

description: A group of immune diseases characterized predominantly by immune dysregulation leading to organ-specific autoimmunity, excessive inflammation, and non-malignant lymphoproliferation. Unlike classical primary immunodeficiencies, susceptibility to infections is typically less prominent in these disorders.


name: acute myelomonocytic leukemia in relapse

description: The reemergence of acute myelomonocytic leukemia after a period of remission.


name: Bile Duct Intraductal Papillary Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of moderate epithelial atypia.


Stage IVA Fallopian Tube Cancer AJCC v8

description: Stage IVA includes: Any T, Any N, M1a. M1a: Fallopian tube cancer with pleural effusion with positive cytology. (from AJCC 8th Ed.)


Retinoma

description: A rare, unilateral or bilateral benign neoplasm that arises from the retina. There is an increased risk of malignant transformation to retinoblastoma; therefore, patients with a diagnosis of retinocytoma should be closely observed.


Intra-Abdominal Lymphangioma

description: A lymphangioma arising from the organs of the abdominal cavity.


name: Extrahepatic Bile Duct Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


name: Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Skin

description: An epithelioid malignant peripheral nerve sheath tumor that arises from the skin.


Refractory Brain Neoplasm

description: Brain neoplasm that is resistant to treatment.


Idiopathic Basal Ganglia Calcification

description: Basal ganglia calcification for which no underlying cause can be identified.


Extracutaneous Merkel Cell Carcinoma

description: A rare Merkel cell carcinoma that arises from extracutaneous sites, including the oral cavity, salivary glands, breast, vulva, and vaginal wall.


name: Stage I Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of a single lymph node region or involvement of a single extra-lymphatic organ or site, without lymph node involvement. This definition applies to both tiers (tier 1 and 2).  (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Lipomatous hamartoma

description: A benign hamartomatous lesion composed predominantly of adipose tissue.


Adenocarcinoma in situ in a polyp

description: An adenocarcinoma arising in a polyp.


Appendix Tubular Adenoma

description: An adenoma arising from the appendix.  It is characterized by the presence of tubular epithelial structures and it is associated with dysplasia.


name: Refractory Childhood Acute Myeloid Leukemia

description: Childhood acute myeloid leukemia that does not respond to treatment.


name: Acute Myeloid Leukemia with t(11;19)(q23.3;p13.3); KMT2A-MLLT1

description: An acute myeloid leukemia associated with t(11;19)(q23.3;p13.3) resulting in KMT2A-MLLT1 gene fusion. It usually affects infants and children.


Indolent T-Lymphoblastic Proliferation

description: A non-neoplastic T-cell lymphoproliferation that may mimic T-lymphoblastic lymphoma. It usually involves the lymphoid tissues of the upper aerodigestive tract. It recurs locally, but systemic dissemination is rare.


name: Stage IIB Esophageal Adenocarcinoma AJCC v7

description: Stage IIB includes: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Recurrent Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A

description: The reemergence of acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A after a period of remission.


Recurrent Lymphoproliferative Disorder

description: The reemergence of a lymphoproliferative disorder after a period of remission.


Recurrent Digestive System Carcinoma

description: The reemergence of carcinoma in any part of the digestive system after a period of remission.


Blennorrhagic arthritis

description: A form of reactive arthritis that is associated with lesions on both the palms of the hands and the soles of the feet.


name: Metastatic Distal Esophagus Adenocarcinoma

description: Distal esophagus adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Invasive Bladder Urothelial Carcinoma with Glandular Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits glandular differentiation.


Myelophthisis

description: A condition resulting from the destruction of bone marrow precursor cells and their stroma. Bone marrow is displaced by fibrosis, tumors, or granulomas.


Congenital Unilateral Cataract

description: Cataract in one eye that is present at birth.


Keratitis caused by infection

description: Inflammation of the cornea secondary to an infectious process.


Craniopharyngioma malignant

description: A rare condition characterized by the development of a carcinoma in a pre-existing craniopharyngioma.


Stage III Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Localized Carcinoma

description: A carcinoma that is confined to a specific site without evidence of spread to other anatomic sites.


Childhood Malignant Glioma

description: A malignant glioma that occurs during childhood.


name: Stage I Adult Diffuse Large Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


name: Gastric Pylorus Carcinoma In Situ AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Hodgkin's disease, nodular sclerosis - mixed cellularity

description: Nodular sclerosis Hodgkin lymphoma in which at least 75% of the tumor nodules contain scattered Reed-Sternberg cells. The background cellular infiltrate is lymphocytic, mixed, or fibrohistiocytic.


name: Recurrent T-Cell Prolymphocytic Leukemia

description: The reemergence of T-cell prolymphocytic leukemia after a period of remission.


Cheilognathouranoschisis

description: A congenital abnormality consisting of a fissure in the midline of the lip, hard and/or soft palate and upper jaw.


name: Lymphocyte Predominant Type Hodgkin's Disease

description: An antiquated term that refers either to nodular lymphocyte predominant Hodgkin lymphoma or to lymphocyte-rich classical Hodgkin lymphoma.


Cerebellar Peduncle Neoplasm

description: A benign or malignant neoplasm that affects the cerebellar peduncle.


Anal Hidradenoma Papilliferum

description: A benign neoplasm arising from the perianal sweat glands. It presents as a cystic nodular lesion and is characterized by the presence of cystic and papillary structures. The papillary structures contain connective tissue and are covered by two layers of epithelium.


Metastatic Low Grade Astrocytoma

description: Low grade astrocytoma that has spread from its primary site to another anatomic site.


name: Clonal Monocytosis of Undetermined Significance

description: A myelodysplastic/myeloproliferative neoplasm characterized by the presence of persistent monocytosis, presence of at least one myeloid neoplasm-associated mutation, absence of significant dysplasia or increased blasts in the bone marrow, absence of morphologic findings suggestive of chronic myelomonocytic leukemia in the bone marrow, and absence of history of a reactive condition that would explain the persistent monocytosis.


Recurrent Vulvar Carcinoma

description: The reemergence of vulvar carcinoma after a period of remission.


Malignant neoplasm of stomach stage IV

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 7th ed.)


name: Pathologic Stage 0 Merkel Cell Carcinoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: In situ primary tumor. N0: No regional lymph node metastasis detected on pathologic examination. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Hodgkin's disease lymphocyte depletion type recurrent

description: The reemergence of lymphocyte-depleted classic Hodgkin lymphoma after a period of remission.


Stage IB1 Cervical Cancer AJCC v9

description: Stage IB1 includes: T1b1, N0, M0. T1b1: Tumor measuring more than 5 mm in depth and equal or less than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Gemistocytic Astrocytoma, IDH-Mutant

description: Gemistocytic astrocytoma carrying IDH mutations.


name: Pathologic Stage IV Merkel Cell Carcinoma AJCC v8

description: Stage IV includes: T0-4, Any N, M1. T0: No evidence of primary tumor. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. M1: Distant metastasis microscopically confirmed. (AJCC 8th ed.)


Vaginal Papillary Carcinoma

description: A rare squamous cell carcinoma that arises from the vagina resembling transitional cell carcinoma of the urinary tract.


name: Refractory Fallopian Tube Transitional Cell Carcinoma

description: Fallopian tube transitional cell carcinoma that is resistant to treatment.


Esophageal Infection

description: An infectious process affecting the esophagus.


Localized Malignant Solid Neoplasm

description: A malignant solid neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


Leukoplakia of anus

description: The presence of a painless whitish patch on the anal mucosa.  Histologic examination reveals hyperkeratosis and acanthosis.


Mixed Hyperlipidemia

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Stage II Bladder Cancer AJCC v8

description: Stage II includes: (T2a, N0, M0); (T2b, N0, M0). T2a: Tumor invades superficial muscularis propria (inner half). T2b: Tumor invades deep muscularis propria (outer half). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage IIIA Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Involvement of lymph node regions on both sides (above and below) of the diaphragm. This may be accompanied by extra-lymphatic extension in association with adjacent lymph node involvement (i.e., local extension from a lymph node area into a nearby organ) and/or involvement of spleen. No constitutional symptoms are recorded. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Tubular Neoplasm

description: A benign or malignant neoplasm characterized by the presence of a tubular architecture. This category includes tubular adenomas and tubular carcinomas.


name: Lacrimal Drainage System Exophytic Papilloma

description: A benign exophytic papillary neoplasm that arises from the lacrimal drainage system. It consists of fibrovascular cores lined by epithelial cells.


name: Abnormal Blood Chemistry and Hematology Test Result

description: A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values.


name: Hodgkin's disease mixed cellularity stage I subdiaphragmatic


Anal infection

description: An infectious process affecting the anal area.


Reserve Cell Hyperplasia

description: Hyperplasia of the immature cells located between the surface columnar epithelium and the basal layer.


name: Hodgkin's Disease, Lymphocyte Depletion, Reticular

description: A lymphocyte depleted Hodgkin lymphoma characterized by the presence of reticular fibrosis.


name: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

description: Limited stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


Lacrimal Gland Acinic Cell Carcinoma

description: An extremely rare, low-grade, salivary gland-type carcinoma that arises from the lacrimal gland. It exhibits acinar differentiation.


Urethral Infection

description: A bacterial, viral, or fungal infectious process affecting the urethra.


Biliary Intraepithelial Neoplasia-2

description: Biliary intraepithelial neoplasia characterized by the presence of moderate epithelial atypia.


Recurrent Malignant Brain Neoplasm

description: The reemergence of a malignant brain neoplasm after a period of remission.


Abdominal Rhabdomyosarcoma

description: Rhabdomyosarcoma involving the organs and structures in the abdomen.


Injection site thrombophlebitis

description: Thrombophlebitis in the veins surrounding an injection site.


name: Refractory Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Accelerated phase chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment.


Rare Diseases

description: A non-neoplastic or neoplastic disorder that is uncommon.


name: Microvascular Thrombosis Related to COVID-19

description: Blood clot formation in the small blood vessels of the body in a patient with probable or confirmed acute COVID-19.


name: Ann Arbor Stage II Lymphocyte-Depleted Classic Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Prosthetic Valve Thrombosis

description: The formation of a blood clot that is attached to or near an artificial heart valve; this can cause dysfunction of the valve, and possibly lead to an embolic event should the thrombus become dislodged.


Vulvar Dysplastic Melanocytic Nevus

description: A rare, elevated and pigmented, compound or junctional nevus that arises from the vulva. It affects women in their reproductive years and may be associated with the presence of dysplastic nevi in other anatomic areas. It is characterized by the presence of epithelioid or spindle-shaped melanocytes exhibiting nuclear pleomorphism and prominent nucleoli.


name: Borderline Ovarian Serous Papillary Cystic Tumor

description: A neoplasm of low malignant potential arising from the ovary. It is characterized by the presence of papillary proliferations of atypical serous epithelial cells and a cystic component.  There is no evidence of stromal invasion.


Unresectable Malignant Gastric Neoplasm

description: A malignant gastric neoplasm that is not amenable to surgical resection.


name: Invasive Bladder Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive bladder urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Metastatic NUT Carcinoma

description: NUT carcinoma that has spread from its original site of growth to another anatomic site.


Peritoneal Sarcomatosis

description: A condition in which a sarcoma has spread extensively throughout the peritoneum.


Dehiscence

description: A splitting open of an anatomical structure, zone, or organ with the exposure or discharge of its content.


Infective cystitis

description: An infectious process affecting the urinary bladder.


Diffuse Midline Glioma, H3 K27-Altered

description: A diffuse midline glioma characterized by H3 K27 alteration and usually either a histone H3 K27M mutation, an EGFR mutation, or aberrant overexpression of EZHIP. The prognosis is poor.


Refractory WHO Grade 2 Glioma

description: WHO grade 2 glioma that is resistant to treatment.


name: Metastatic Bladder Plasmacytoid Urothelial Carcinoma

description: Bladder plasmacytoid urothelial carcinoma that has spread to another anatomic site.


name: IgM Monoclonal Gammopathy of Undetermined Significance, Plasma Cell Type

description: A subtype of IgM monoclonal gammopathy of undetermined significance characterized by the presence of clonal plasma cells, absence of clonal B-lymphocytes, and absence of MYD88 gene mutation. The t(11;14)(q13;q32) is present in some cases. This subtype is considered a precursor of multiple myeloma.


name: Unresectable Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and is not amenable to surgical resection.


Non-Neoplastic Mediastinal Disorder

description: A non-neoplastic disorder that affects the structures of the mediastinum.  Representative examples include mediastinitis and thymic hyperplasia.


Cytomegalovirus gastroenteritis

description: Gastroenteritis resulting from an infection with cytomegalovirus.


Childhood Digestive System Neoplasm

description: A neoplasm that affects any part of the digestive system and occurs during childhood.


Mixed Trophoblastic Tumor

description: A gestational trophoblastic tumor characterized by the presence of two or three histological types of gestational trophoblastic tumor, including choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor.


Stage 0 Gallbladder Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Neuropathy, Recurrent, with Pressure Palsies

description: An autosomal dominant condition caused by mutation(s) in the PMP22 gene, encoding peripheral myelin protein 22. Neuropathy is precipitated by mechanical compression on a nerve, typically with onset in the first and second decades.


Stage III Merkel Cell Carcinoma AJCC v7

description: Stage III includes: IIIA: (Any T, N1a, M0) and IIIB: (Any T, N1b/N2, M0).  N1a: Micrometastasis in regional lymph nodes.  N1b: Macrometastasis in regional lymph nodes.  N2: In transit metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Stage IIA Gallbladder Cancer AJCC v8

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Fibrohistiocytic Neoplasm

description: A benign, intermediate, or malignant mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern.


Stage IIB Cervical Cancer AJCC v9

description: Stage IIB includes: T2b, N0, M0. T2b: Tumor with parametrial invasion but not up to the pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Unresectable Sarcoma

description: A sarcoma which is not amenable to surgical resection.


name: Stage II Gestational Trophoblastic Neoplasm AJCC v8

description: Stage II includes: T2, M0. T2: Gestational trophoblastic neoplasm in which the tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Smoldering Systemic Mastocytosis with an Associated Myeloid Neoplasm

description: Smoldering systemic mastocytosis associated with the presence of a clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome,  myeloproliferative neoplasm, and acute myeloid leukemia).


name: Human papillomavirus negative squamous cell carcinoma

description: A squamous cell carcinoma not associated with human papilloma virus infection.


Stage II Cervical Cancer AJCC v6

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0). T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Recurrent Anal Mucinous Adenocarcinoma

description: The reemergence of anal mucinous adenocarcinoma after a period of remission.


Prostate Cancer by AJCC v7 Stage

description: A term that refers to the staging of prostate carcinoma according to the American Joint Committee on Cancer, 7th edition.


PALB2-Associated Malignant Neoplasm

description: A malignant neoplasm caused by deleterious germline mutation in the PALB2 gene. This mutation is associated with the development of breast carcinoma and pancreatic carcinoma.


Maternal Proteinuria

description: The presence of excessive protein, chiefly albumin but also globulin, in the urine of a pregnant woman.


Liver Neuroendocrine Tumor G1

description: A well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is less than 2 per 10 HPF.


Rare Malignant Solid Neoplasm

description: A malignant solid neoplasm with an annual incidence of less than 6 per 100,000 people.


name: Pancreatic Moderately Differentiated Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures.


name: Steroid-Dependent Gastrointestinal Tract Acute Graft Versus Host Disease

description: Gastrointestinal tract acute graft versus host disease that is responsive to treatment with steroids but relapses during attempts at tapering or discontinuing steroid therapy.


Surfactant Protein D Deficiency

description: Deficiency of surfactant protein D. When present in normal amounts, this protein offers protection against pulmonary infection and inflammation.


Esophageal Cancer by AJCC v7 Stage

description: A term that refers to the staging of esophageal carcinoma according to the American Joint Committee on Cancer, 7th edition.


Type I Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to endometrioid adenocarcinoma and mucinous adenocarcinoma.


Stage 0 Vulvar Cancer AJCC v6

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Low Grade Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


name: Hemolytic disease of fetus OR newborn due to ABO immunization

description: A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of anti-A or anti-B antibodies from a mother to the child via the placenta against A or B antigens of the newborn's blood.


name: Prostate Carcinoma Metastatic in the Soft Tissue

description: A carcinoma that arises from the prostate gland and has spread to the soft tissues.


name: Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIIA includes: T0-2, N1, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic malignant neoplasm to viscera

description: A malignant neoplasm which has spread from its original site of growth to any visceral site.


name: Cytogenetically normal acute myeloid leukemia

description: Acute myeloid leukemia not associated with cytogenetic abnormalities.


Adenocarcinoma in tubulovillous adenoma

description: A non-invasive or invasive adenocarcinoma arising from a tubulovillous adenoma.


Breast Solid Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the breast.  It is characterized by the presence of cellular solid nests and trabeculae that contain spindle-shaped, plasmacytoid, and large neuroendocrine cells.


Food Poisoning

description: Any disorder that results from the consumption of food contaminated with an infectious agent or toxin.


Primary Meningeal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the leptomeninges. This category includes diffuse proliferative processes (melanocytosis and melanomatosis) and circumscribed processes (melanocytoma and melanoma).


name: Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8

description: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the CSF, bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


Gastric infection

description: An acute or chronic infectious process affecting the stomach.


Anal Inflammatory Cloacogenic Polyp

description: A non-neoplastic polypoid lesion that arises from the anal transitional zone.  It is characterized by the presence of hyperplastic rectal mucosa that is partially covered by squamous or transitional epithelium.


name: Peritoneal and retroperitoneal disorders

description: A non-neoplastic or neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Stage IIB Cervical Cancer AJCC v8

description: Stage IIB includes: T2b, Any N, M0. T2b: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina with parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Single Ventricle Defect

description: A diverse group of congenital cardiovascular abnormalities that share one characteristic, the presence of a single functional cardiac ventricle.


name: Non-Neoplastic Digestive System Disorder

description: A non-neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. Representative examples include infections, ulcers, cirrhosis, and diverticulosis.


Second Primary Tumor

description: A new primary neoplasm that occurs in a person who was previously diagnosed with another primary neoplasm.


name: Infiltrating Ureter Urothelial Carcinoma with Mixed Differentiation


Metastatic non-small cell carcinoma

description: Non-small cell carcinoma that has spread from its original site of growth to another anatomic site.


Malignant Visual Pathway Neoplasm

description: A primary or metastatic malignant neoplasm that affects the visual pathway.


Metastatic Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread to another anatomic site.


Sternotomy Scar

description: Replacement of destroyed tissue by fibrous tissue due to a surgical procedure where a vertical inline incision is made along the sternum, after which the sternum itself is divided. (ACC/AHA)


name: Refractory Histiocytic and Dendritic Cell Neoplasm

description: A histiocytic and dendritic cell neoplasm that does not respond to treatment.


Stage IIC Merkel Cell Carcinoma AJCC v7

description: Stage IIC includes: T4, N0, M0.  T4: Primary tumor invades bone, muscle, fascia, or cartilage.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th Ed.)


Nail Matrix Nevus

description: An acral nevus that arises from the nail matrix.


Myeloid Neoplasm with Mutated TP53

description: Myeloid neoplasm characterized by the presence of TP53 gene mutations. This category includes myelodysplastic syndrome, myelodysplastic syndrome/acute myeloid leukemia, and acute myeloid leukemia with mutated TP53.


name: Lugano Classification Stage II Childhood Hodgkin Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Cutaneous Juvenile Xanthogranuloma

description: A benign histiocytic tumor that arises from the skin and occurs during childhood; it is distinct from Langerhans cell histiocytosis. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells in the dermis. The lesions usually develop during infancy. They consist of cutaneous papules and nodules (most often in the head and neck).


name: Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Epilepsy congenital

description: A seizure disorder that is present at the time of birth.


name: Stage IIIA Cervical Cancer AJCC v6 and v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Appendix Tubulovillous Adenoma

description: An adenoma arising from the appendix.  It is characterized by the presence of tubular and villous epithelial structures and it is associated with dysplasia.


Favorable Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis.


Unspecified dermatitis due to sun

description: Inflammation of the skin resulting from exposure to the sun.


Stage III Testicular Cancer AJCC v8

description: Stage III includes: Any pT/TX, Any N, M1, SX. TX: Testicular cancer in which the primary tumor cannot be assessed. M1: Testicular cancer with distant metastasis. SX: Marker studies not available or not performed. (AJCC 8th ed.)


Benign Musculoskeletal Neoplasm

description: A mesenchymal neoplasm that arises from muscle or bone and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Acute Myeloid Leukemia with t(5;17)(q35;q21); NPM1-RARA

description: Acute myeloid leukemia with the variant RARA t(5;17)(q35;q21) and the expression of NPM1-RARA fusion protein.


name: Vaginal intraepithelial neoplasia grade 1

description: Vaginal intraepithelial neoplasia characterized by the presence of koilocytosis and disorganization and thickening of the basal layer.


name: Localized Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that is restricted to the site of origin without evidence of metastasis.


Fine motor delay

description: Delayed acquisition of age appropriate motor milestones that produce small and precise movements.


name: Recurrent Malignant Endocervical Neoplasm

description: The reemergence of a malignant neoplasm of the endocervix after a period of remission.


name: Stage IA Gestational Trophoblastic Tumor AJCC v7

description: Stage IA includes: T1, M0, Risk factors: low risk.  T1: Tumor confined to uterus.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Sclerodermatous Graft Versus Host Disease

description: A rare form of chronic graft-versus-host disease characterized by cutaneous features and/or mucocutaneous features including sclerosis, atrophy, and contractures. It may manifest as localized or generalized disease.


Chronic Myelomonocytic Leukemia-1

description: A chronic myelomonocytic leukemia characterized by the presence of less than 10 percent blasts in the bone marrow and less than 5 percent blasts in the peripheral blood.


name: Stage 0 Gallbladder Cancer AJCC v6 and v7

description: Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Differentiated Granulocytic Sarcoma

description: A granulocytic sarcoma composed of promyelocytes and more mature neutrophils (WHO 2001).


name: Malignant mesothelioma of tunica vaginalis

description: A rare malignant mesothelioma that arises from the tunica vaginalis.


Celosomy

description: A developmental abnormality characterized by the complex protrusion of viscera outside the abdominal wall.


Phobia, School

description: An overwhelming, irrational, and persistent fear of attending school.


name: squamous cell carcinoma of urinary tract

description: A rare squamous cell carcinoma that arises from the urinary tract. Almost all cases have been reported in the bladder. Causes include urinary stasis, recurrent chronic inflammation, and smoking. In regions where schistosomiasis is endemic, it is the major etiologic factor of bladder squamous cell carcinoma.


Diffuse Mixed-Cell Lymphoma

description: An antiquated term referring to non-Hodgkin lymphomas with a mixed cellular composition. This term applies to both B- and T- cell non-Hodgkin lymphomas.


name: Recurrent Cervical Squamous Cell Carcinoma

description: The reemergence of cervical squamous cell carcinoma after a period of remission.


name: Intrahepatic Bile Duct Microcystic Adenoma

description: An adenoma that arises from the intrahepatic bile ducts and it is characterized by the presence of microcystic changes.


Refractory WHO Grade 3 Glioma

description: A WHO grade 3 glioma that is resistant to treatment.


Non-Hematologic Malignancy

description: A malignant neoplasm that arises from a site other than the bone marrow and lymphoid tissue.


name: Metastatic Micropapillary Urothelial Carcinoma

description: Micropapillary urothelial carcinoma that has spread to another anatomic site.


Brain Diseases, Metabolic

description: A group of neurologic disorders caused by alterations to the biochemical functioning of the brain. They are characterized by an altered level of consciousness and depressed cerebral functioning.


name: Pathologic Stage II Cutaneous Melanoma AJCC v8

description: Stage II includes: IIA: (T2b, N0, M0); (T3a, N0, M0); IIB: (T3b, N0, M0); (T4a, N0, M0); IIC: (T4b, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage IC Fallopian Tube Cancer AJCC v8

description: Stage IC includes: T1c, N0, M0. T1c: Fallopian tube cancer with tumor limited to fallopian tubes, with any of the following: surgical spill, capsule ruptured before surgery or tumor on fallopian tube surface, or malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Metastatic gastric adenocarcinoma

description: A gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Endometrial Endometrioid Adenocarcinoma with Small Glands, Tubules or Cords


Unresectable Vulvar Carcinoma

description: Vulvar carcinoma that is not amenable to surgical resection.


Stage I Gastric Cancer AJCC v6

description: Stage I includes: IA: (T1, N0, M0) and IB: (T1, N1, M0); (Ta/b, N0, M0).  T1: Tumor invades lamina propria or submucosa.  T2: Tumor invades the muscularis propria or the subserosa.  T2a: Tumor invades muscularis propria. T2b: Tumor invades subserosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


name: Stage I Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 1 cm or less and is confined within the sphincter of Oddi. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Neuronevus

description: An intradermal nevus characterized by the presence of nests of atrophic nevus cells which are hyalinized and resemble nerve bundles.


MGMT-Unmethylated Glioblastoma

description: A glioblastoma characterized by the absence of DNA methylation in the promoter region of the MGMT gene. It is associated with a poor outcome.


Shunt thrombosis

description: The presence of a thrombus within a vascular shunt.


name: Benign Peritoneal and Retroperitoneal Neoplasm

description: A neoplasm that arises from the peritoneum and/or retroperitoneum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Metastatic Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


name: Localized Childhood Astrocytoma by Toronto Guidelines v2

description: Localized disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Stage IIIA Bladder Cancer AJCC v8

description: Stage IIIA includes: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). M0: No distant metastasis. (AJCC 8th ed.)


Moderate Grade Fever

description: Body temperature ranging between 102.1 degrees Fahrenheit (39 degrees Celsius) and 103.9 degrees Fahrenheit (39.9 degrees Celsius).


name: Agoraphobia without history of panic disorder

description: An anxiety disorder characterized by agoraphobia in the absence of a history of panic attacks; the individual fears incapacitation or humiliation in open, public places or situations due to panic-like symptoms rather than a full-blown panic attack.


name: Stage II Childhood Retinoblastoma by Toronto Guidelines v2

description: Enucleation with microscopic residual disease. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal glandular epithelium.


Cervical Yolk Sac Tumor

description: A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina.


Enterovesical Fistula

description: An abnormal communication between the urinary bladder and the intestine.


Verruca Palmaris

description: A wart on the palmar surface of the hand. It is caused by human papillomavirus.


name: Pathologic Stage II Retinoblastoma AJCC v8

description: Stage II includes: pT4, pN0, cM0, Any H. pT4: Evidence of extraocular tumor: tumor at the transected end of the optic nerve, tumor in the meningeal spaces around the optic nerve, full-thickness invasion of the sclera with invasion of the episclera, adjacent adipose tissue, extraocular muscle, bone, conjunctiva, or eyelids. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Recurrent Urethral Cancer

description: The reemergence of urethral carcinoma after a period of remission


name: Developmental and Epileptic Encephalopathy 44

description: An autosomal recessive subtype of developmental and epileptic encephalopathy caused by mutation(s) in the UBA5 gene, encoding ubiquitin-like modifier-activating enzyme 5.


Neuroendocrine carcinoma, metastatic

description: A neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


Mental disorder in childhood

description: A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence.


name: Myelodysplastic Syndrome, Unclassifiable, with Single Lineage Dysplasia

description: Myelodysplastic syndrome, unclassifiable characterized by unilineage dysplasia and associated pancytopenia.


Stage I Urethral Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: For male penile urethra and female urethra: Tumor invades subepithelial connective tissue. For prostatic urethra: Tumor invades urethral subepithelial connective tissue immediately underlying the urothelium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: malignant neoplasm of lacrimal apparatus

description: A primary or metastatic malignant neoplasm affecting the lacrimal gland or the lacrimal drainage system.


Recurrent Tectal Glioma

description: The reemergence of tectal glioma after a period of remission.


name: Supratentorial Ependymoma, Not Elsewhere Classified

description: A circumscribed ependymoma that arises from the supratentorial region of the brain, characterized by the absence of a fusion gene involving ZFTA or YAP1 genes.


Ossification of the Ligamentum Flavum

description: A condition in which the ligamentum flavum is progressively ossified which may cause compression of elements inside the spinal canal, resulting in various neurological symptoms.


name: Secondary Supratentorial Anaplastic Astrocytoma

description: An anaplastic astrocytoma occurring in the supratentorial area secondary to a preexisting tumor.


neoplasm of corpus callosum

description: A benign or malignant neoplasm that affects the corpus callosum.


name: Steroid Refractory Graft Versus Host Disease

description: Graft versus host disease that does not respond to steroid treatment.


name: Lugano Classification Stage II Adult Hodgkin Lymphoma AJCC v8

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


Desmoplastic trichoepithelioma

description: A benign adnexal tumor occurring in the face of young female subjects. It is characterized by the presence of epithelial neoplastic cells and keratinous cysts in a desmoplastic stroma.


name: Ampulla of Vater Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region.  It is characterized by the presence of malignant large cells.


Locally Advanced Melanoma

description: Melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Hereditary Paraganglioma

description: A hereditary neoplasm arising from paraganglia. The majority of cases (up to 80%) are multifocal. It is caused by mutations in SDHA, SDHB, SDHC, SDHD, and SDHAF2 genes.


Malignant Intracranial Germ Cell Tumor

description: A malignant germ cell tumor that affects the structures within the cranium.


Secondary Plasma Cell Leukemia

description: Transformation of plasma cell myeloma to plasma cell leukemia.


name: Invasive Bladder Urothelial Carcinoma Associated with Urethral Carcinoma

description: Invasive urothelial carcinoma of the bladder which is associated with the presence of in situ or infiltrating urethral carcinoma.


name: Borderline Paratesticular Mucinous Tumor

description: A rare, non-invasive, mucinous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical mucinous epithelial cells. Metastases have not been reported.


name: Acute Myocardial Injury with Heart Failure Related to COVID-19

description: Acute myocardial injury with evidence of new or worsening signs and symptoms of heart failure in a patient with probable or confirmed acute COVID-19.


name: Recurrent Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: The reemergence of extrapulmonary large cell neuroendocrine carcinoma after a period of remission.


Flexural Skin Nevus

description: A benign nevus occurring in the flexural skin.


name: FIGO Grade 2 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains 6-50% non-squamous solid areas.


Malignant mastocytosis

description: A group of malignant mast cell disorders including aggressive systemic mastocytosis, mast cell leukemia, mast cell sarcoma, and systemic mastocytosis with an associated myeloid neoplasm. Individuals with advanced systemic mastocytosis have a reduced life expectancy, with median survival measured in months to years.


Acute Placental Infarction

description: A focus of necrotic placental parenchyma with clearly visible outlines of necrotic villous structures and absence of any hyalinization and fibrosis, which is frequently 1-2 days of duration.


name: Recurrent Vaginal Squamous Cell Carcinoma

description: The reemergence of vaginal squamous cell carcinoma after a period of remission.


High Grade Endometrioid Adenocarcinoma

description: Endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


name: Cerebellar Glioneuronal and Neuronal Tumors

description: Glioneuronal and neuronal tumors occurring in the cerebellum.


name: Temporal Lobe Pleomorphic Xanthoastrocytoma

description: A pleomorphic xanthoastrocytoma that arises from the temporal lobe of the brain.


name: Refractory Fallopian Tube Endometrioid Adenocarcinoma

description: Fallopian tube endometrioid adenocarcinoma that is resistant to treatment.


name: Intermediate Osteoclastic Giant Cell-Rich Tumor of Bone

description: A benign but locally aggressive giant cell tumor that arises from the bone.


Stage IB Esophageal Cancer AJCC v7

description: Stage IB includes: For squamous cell carcinoma: (T1, N0, M0, G2-3, Tumor location: Any); (T2-3, N0, M0, G1, GX, Tumor location: Lower, X). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1, N0, M0, G3); (T2, N0, M0, G1-2, GX).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated.  G3: Poorly differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Stage IV Esophageal Cancer AJCC v7

description: Stage IV includes: For squamous cell carcinoma: Any T, Any N, M1, Any G, Tumor location: Any.  For adenocarcinoma: Any T, Any N, M1, Any G. M1: Distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Tracheal Verrucous Carcinoma

description: An exophytic, warty, well differentiated, slow growing and non-metastasizing squamous cell carcinoma arising from the trachea.


name: Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood ependymoma according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Sleep Disorder due to General Medical Condition

description: A sleep disorder (insomnia, hypersomnia, or parasomnia) for which there is strong physiological evidence that the disorder is etiologically linked to a general medical condition.


name: Other Genetic Syndrome Associated with Congenital Heart Defect

description: An indication that the patient has a history of a genetic syndrome associated with a congenital heart defect other than those listed.


Advanced Uterine Corpus Cancer

description: Uterine corpus cancer that has spread extensively to other anatomic sites or is no longer responding to treatment.


Localized Pancreatic Adenocarcinoma

description: An adenocarcinoma that arises from the pancreas and has not spread to other anatomic sites.


Recurrent Malignant Lymphoid Neoplasm

description: The reemergence of a malignant lymphoid neoplasm after a period of remission.


name: Langerhans Cell Histiocytosis, Disseminated

description: Langerhans cell histiocytosis presenting with disseminated disease.


Cutaneous Melanoma of the Extremity

description: A cutaneous melanoma that arises from the upper or lower extremity.


Surfactant Protein Deficiency

description: A congenital deficiency of one of the surfactant proteins.


name: acute diastolic congestive heart failure

description: Acute congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


name: Myelodysplastic Syndrome, Unclassifiable, with 1 Percent Blasts

description: Myelodysplastic syndrome, unclassifiable characterized by refractory cytopenia with unilineage dysplasia or refractory cytopenia with multilineage dysplasia but with 1 percent blasts in the peripheral blood.


Device related infection

description: An infectious disorder caused by the use of a medical device.


name: Fallopian Tube High Grade Serous Adenocarcinoma

description: A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.


Medullary carcinoma

description: A term referring to medullary carcinomas which can develop in various anatomic sites such as the thyroid gland, breast, colon, rectum, and small intestine.


Refractory Basal Cell Carcinoma

description: Basal cell carcinoma that is resistant to treatment.


name: Childhood Malignant Nervous System Neoplasm

description: A primary or metastatic malignant neoplasm that affects the nervous system and occurs during childhood.


Adrenocortical hyperplasia

description: Congenital or acquired hyperplasia of the cells of the adrenal cortex.


Vaginal abscess

description: An abscess that is located in the vagina.


Malignant tumor of optic nerve

description: A primary or metastatic malignant neoplasm that affects the optic nerve.


Bacillary Peliosis

description: An infection that is caused by Bartonella henselae, which occurs primarily in immunocompromised persons; it is characterized by blood-filled cysts in the liver and spleen.


name: Multifocal nodular oncocytic hyperplasia of salivary gland

description: A rare lesion characterized by multiple non-neoplastic nodular proliferations composed of cells with abundant granular eosinophilic cytoplasm (oncocytes) and/or clear cytoplasm (clear cells) in one or both parotid glands. (WHO 2017)


COVID-19-Associated Myalgia

description: Myalgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Stage IIB Bone Cancer AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Placental Malformation

description: A non-neoplastic abnormality that affects the placenta. Representative examples include multi-lobed and bilobed placenta.


Childhood Infectious Disorder

description: An infectious disorder that occurs in childhood.


name: Acute gonococcal infection, of upper genitourinary tract

description: A gonococcal infection of the upper urinary tract that is rapid in onset.


Lipidized Glioblastoma

description: A rare glioblastoma characterized by the presence of a predominant population of neoplastic cells with foamy cytoplasm.


Maternal Sepsis

description: A pathologic response to infection in a mother or pregnant woman.


name: Lugano Classification Advanced Stage Childhood Hodgkin Lymphoma AJCC v8

description: Advanced stage childhood Hodgkin lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


name: Stage IV Esophageal Adenocarcinoma AJCC v7

description: Stage IV includes: Any T, Any N, M1, Any G.  M1: Distant metastasis.  (AJCC 7th ed.)


name: Endometrial Mucinous Adenocarcinoma, Gastric-Type

description: A rare mucinous adenocarcinoma arising from gastric metaplasia of the endometrium.


Adult Anaplastic (Malignant) Meningioma

description: An anaplastic (malignant) meningioma occurring in adults.


Neonatal Listeriosis

description: A bacterial infection by Listeria monocytogenes in a newborn infant up to 28 days old.


name: Serous papillary cystic tumor of borderline malignancy

description: A low malignant potential cystic serous epithelial neoplasm arising from the ovary. Cases with identical morphology have been described arising from the peritoneum as well. It is characterized by an atypical epithelial proliferation and a papillary growth pattern. There is no evidence of destructive stromal invasion.


name: Stage I Appendix Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor measuring 2 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Executive dysfunction

description: Cognitive, emotional, and behavioral difficulties that often occur in conjunction with frontal lobe disorders, including traumatic injury and dementia. It is also a feature of attention deficit disorder and other non-trauma-induced conditions.


Virus-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific virus as the causative agent.


name: Oligometastatic Pancreatic Ductal Adenocarcinoma

description: Pancreatic ductal adenocarcinoma that has metastasized to a limited number of sites.


Postpartum Obstetric Air Embolism

description: Presence of a large air bubble in the maternal vascular system which originated from a distant site during the postpartum period.


Bone Cancer by AJCC v7 Stage

description: A term that refers to the staging of bone cancer, following the rules of the TNM AJCC v7 classification system.


Non-Neoplastic Heart Disorder

description: A non-neoplastic disorder that affects the heart and/or the pericardium.  Representative examples include congestive heart disease, endocarditis, and constrictive pericarditis.


Stage IB1 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and equal or less than 4 cm in maximum diameter. (FIGO 2009)


name: Precursor T-lymphoblastic lymphoma/leukemia stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Low Grade Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic process characterized by the presence of mild dysplastic cytological changes which are usually present in the lower part of the squamous epithelium.  Representative examples include the low grade esophageal squamous intraepithelial neoplasia, low grade cervical squamous intraepithelial neoplasia, low grade vaginal intraepithelial neoplasia, and low grade vulvar intraepithelial neoplasia.


name: intestinal type adenocarcinoma of gallbladder

description: An adenocarcinoma that arises from the gallbladder.  It is characterized by the presence of neoplastic tubular glands lined by columnar cells or neoplastic glands lined by goblet cells.


Disorder of Androgen Synthesis

description: An enzyme deficiency in the androgen biosynthesis pathway, resulting in the underproduction of one or more androgens by the adrenal glands and/or gonads.


name: Diverticular Carcinoma of the Urinary Tract

description: A carcinoma that arises from a diverticulum in the urinary tract. Most histological subtypes of urinary tract carcinomas have been reported in urinary tract diverticula.


Stage IA Vulvar Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Lesion measuring 2 cm or less, confined to the vulva and/or perineum, and with stromal invasion of 1.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Osteosarcoma AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Stage I Prostate Cancer AJCC v6

description: Stage I includes: T1, N0, M0, G1.  T1: Tumor invades subepithelial connective tissue.  N0: No regional metastasis.  M0: No distant metastasis. G1: Well differentiated (slight anaplasia) (Gleason 2-4).  (AJCC 6th ed.)


name: Recurrent Sclerodermatous Graft Versus Host Disease

description: The reemergence of sclerodermatous graft versus host disease after a period of remission.


Malignant Solitary Fibrous Tumor

description: A malignant neoplasm of probable fibroblastic derivation. It is characterized by the presence of atypical round to spindle-shaped cells, increased cellularity, necrotic change and high mitotic activity.


Recurrent Dedifferentiated Liposarcoma

description: The reemergence of dedifferentiated liposarcoma after a period of remission.


name: Locally Advanced Primary Malignant Central Nervous System Neoplasm

description: A malignant neoplasm that arises from the central nervous system and has spread from its original site of growth to nearby tissues or lymph nodes.


Prostate Basal Cell Carcinoma

description: An invasive prostate carcinoma composed of prostatic basal cells.


Childhood Bone Hemangioma

description: A bone hemangioma that occurs during childhood.


Recurrent Diffuse Glioma

description: The reemergence of a diffuse glioma after a period of remission.


name: Myeloproliferative Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia characterized by the presence of a markedly elevated white blood cell count in the peripheral blood.


Immune-Mediated Coagulopathy

description: Disorders of coagulation caused by autoantibodies generated against native coagulation factors or therapeutically-administered hemostatic agents.


Mesenteric thrombosis

description: Formation of a blood clot (thrombus) in the lumen of a mesenteric vein or mesenteric artery.


Stage IVB Cervical Cancer AJCC v9

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


name: Stage I Low Grade Adult Non-Hodgkin's Lymphoma


Breast Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the breast.


name: Lugano Classification Stage IE Adult Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Diffuse Astrocytoma, IDH-Wildtype

description: Diffuse astrocytoma lacking mutations in IDH1 or IDH2 genes.


Childhood Bone Sarcoma

description: A sarcoma that arises from the bone and occurs during childhood.


Infectious Meningoencephalitis

description: Inflammation of the meninges and brain caused by an infectious agent.


name: Gelatinous transformation of the bone marrow

description: A rare condition characterized by bone marrow fat cell atrophy, loss of hematopoietic cells, and bone marrow deposition of extracellular gelatinous substances containing mucopolysaccharides rich in hyaluronic acid. The pathogenesis is unknown. It presents with weight loss and anemia. It has been associated with infections, alcoholism, anorexia nervosa, cachexia, end stage renal disease, and cancers.


name: Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant


Breast Ductal Hyperplasia

description: Hyperplasia of the epithelial cells in the breast ducts. It includes the atypical ductal hyperplasia, papillary intraductal hyperplasia, intraductal myoepitheliosis, and ductal hyperplasia of the usual type.


Secondary Parathyroid Gland Hyperplasia

description: Parathyroid gland hyperplasia that occurs in response to physiological stimuli (e.g., vitamin D deficiency, hyperphosphatemia, and hypocalcemia).


name: Metastatic Malignant Female Reproductive System Neoplasm

description: A malignant neoplasm that arises in the female reproductive system and has spread from its original site of growth to other anatomic sites.


Gastric Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the stomach. The Ki-67 index is higher than 20%.


Locally Advanced Esophageal Carcinoma

description: Esophageal carcinoma that has spread to nearby tissues or lymph nodes.


Childhood Anaplastic Ependymoma

description: An anaplastic ependymoma that occurs during childhood.


Tumor of the Thecoma/Fibroma Group

description: A sex cord-stromal tumor that arises from the ovary or the testis. Representative examples include fibroma, fibrosarcoma, and thecoma.


Listerial endocarditis

description: Endocarditis caused by bacterial infection with Listeria species.


Fat adherence syndrome

description: Violation of Tenon's capsule with prolapse of orbital fat into the sub-Tenon's space.


Stage I Cutaneous Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


name: Locally Advanced Digestive System Neuroendocrine Neoplasm

description: A digestive system neuroendocrine neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Advanced Non-Functioning Neuroendocrine Tumor

description: A non-functioning neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


Urethrotrigonitis

description: Inflammation of both the urethra and the trigone of the urinary bladder.


name: Lugano Classification Stage III Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


Stage III Ureter Cancer AJCC v8

description: Stage III includes: T3, N0, M0. T3: Tumor invades beyond muscularis into periureteric fat. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Meningioangiomatosis

description: A rare vascular malformation in the cerebral cortex and overlying leptomeninges.  It can occur sporadically or in association with neurofibromatosis type 2.


Unresectable Lymphoma

description: Lymphoma that is not amenable to surgical resection.


Refractory Solitary Fibrous Tumor

description: Solitary fibrous tumor that is resistant to treatment.


Central Osteoma

description: An osteoma that arises from the endosteum.


name: EBV-Positive Polymorphic B-Cell Lymphoproliferative Disorder, Not Otherwise Specified

description: An EBV-positive B-cell lymphoproliferative disorder characterized by altered tissue architecture and a polymorphic infiltrate that does not fulfill the criteria for the diagnosis of lymphoma and cannot be precisely categorized.


name: Deletion of the Short Arm of Chromosome 1 (1p) Associated Meningioma

description: A meningioma that is associated with deletion of chromosomal arm 1p.


Cockade nevus

description: A rare speckled nevus with concentric pattern of pigmentation and central papule surrounded by clear zone.


Localized Malignant Brain Neoplasm

description: A malignant brain neoplasm that is confined to a specific site without evidence of spread to other anatomic sites.


DDIT4L Acute Lymphoblastic Leukemia

description: A gene expression subtype of acute lymphoblastic leukemia characterized by its expression level of the DDIT4L gene.


name: Childhood Peripheral Nervous System Neoplasm

description: A neoplasm that affects the peripheral nervous system during childhood.


Drug/Toxin-Induced Aplastic Anemia

description: Bone marrow failure defined as pancytopenia, due to exposure to a known toxin or drug.


name: Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8

description: A monotypic HHV8-positive lymphoproliferative disorder that usually occurs in HIV-negative individuals. It is characterized by the presence of HHV8-positive plasmablasts partially or completely replacing germinal centers. Coinfection with EBV is characteristic. In most cases, there is a favorable response to chemotherapy or radiation. (WHO 2017)


Unresectable Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is not amenable to surgical resection.


Childhood Spitz Nevus

description: A Spitz nevus that occurs during childhood.


description: An alveolar rhabdomyosarcoma characterized by the presence of chromosomal translocation t(1;13)(p36;q14) that results in PAX7-FOXO1 gene fusion; or translocation t(2;13)(q35;q14) that results in PAX3-FOXO1 gene fusion.  Approximately 80% of alveolar rhabdomyosarcomas are fusion-positive.


name: AIDS-Related Diffuse Mixed Cell Lymphoma

description: A non-Hodgkin lymphoma occurring in HIV-positive patients.  It is composed of a mixture of lymphocytes of various sizes.


name: Vaginal Small Cell Neuroendocrine Carcinoma

description: A rare small cell neuroendocrine carcinoma that arises from the vagina.


Vulvar Cancer by AJCC v6 Stage

description: A term that refers to the staging of vulvar carcinoma according to the American Joint Committee on Cancer, 6th edition.


Adnexal Cribriform Carcinoma

description: A rare indolent adnexal carcinoma with a cribriform pattern.


name: Pancreatic Poorly Cohesive Adenocarcinoma

description: An adenocarcinoma that arises from the pancreas and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 7

description: Dyskeratosis congenita caused by mutation(s) in the ACD gene, encoding adrenocortical dysplasia protein homolog.


Columnar Cell Change of the Breast

description: A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini.  The acini are lined by one or two layers of columnar epithelial cells.  Apical cytoplasmic snouts may be present, but they are not prominent.  Secretions may be present in the lumina of the dilated acini.


name: Locally Advanced Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial endometrioid adenocarcinoma after a period of remission.


Appendix Carcinoma by AJCC v7 Stage

description: A term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 7th edition. Carcinoid tumors are staged separately. (from AJCC 7th Ed.)


Premenstrual Dysphoric Disorder

description: A more severe form of premenstrual syndrome (PMS) with more extreme mood and physical symptoms. As with PMS, symptoms begin prior to an individual's menstrual cycle and typically taper off as menstruation begins.


Extra Lumbar Vertebra

description: A congenital anomaly of the spine, where an extra or supernumerary lumbar vertebra arises from below the 5th lumbar vertebra.


Stage IB1 Cervical Cancer

description: Stage IB1 includes: T1b1, N0, M0.  T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage III Bone Cancer AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor


description: Transient hyperinsulinism that occurs in response to neonatal stress resulting in prolonged neonatal hypoglycemia, which is distinct from transitional hypoglycemia of typical infants.


name: Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

description: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic/myeloproliferative neoplasm.


Lacrimal Drainage System Melanoma

description: An extremely rare melanoma that arises from the lacrimal drainage system.


AIDS-Related Malignant Neoplasm

description: Malignant neoplasms that develop in HIV infected patients.  The most common AIDS-related malignant neoplasms are Kaposi sarcoma, non-Hodgkin lymphoma, anal carcinoma, cervical carcinoma, and Hodgkin lymphoma.


Unresectable Acral Lentiginous Melanoma

description: Acral lentiginous melanoma that is not amenable to surgical resection.


Locally Advanced Vaginal Carcinoma

description: Vaginal carcinoma that has spread to nearby tissues or lymph nodes.


name: Metastatic Pancreatic Acinar Cell Carcinoma

description: Pancreatic acinar cell carcinoma that has spread from its original site of growth to another anatomic site.


Cervical Cancer by AJCC v8 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 8th edition.


Disseminated Juvenile Xanthogranuloma

description: Juvenile xanthogranuloma disseminated to extracutaneous sites including mucosal surfaces, lung, central nervous system, pituitary, lymph nodes, eye, liver, and bone marrow. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells forming nodules in the affected anatomic sites.


name: Stage II Anal Canal Cancer AJCC v6 and v7

description: Stage II includes: (T2, N0, M0); (T3,N0, M0).  T2: Tumor more than 2 cm but not more than 5 cm in greatest dimension.  T3: Tumor more than 5 cm in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


Recurrent Myeloid Leukemia

description: The reemergence of myeloid leukemia after a period of remission.


name: Metastatic malignant neoplasm to stomach

description: A malignant neoplasm that has spread to the stomach from another organ or system, or from another primary gastric tumor. The primary gastric tumor is not in continuity with the metastatic lesion.  Representative examples of metastatic malignant neoplasms to the stomach include breast, lung, and esophageal metastatic carcinomas and melanomas.


Small cell glioblastoma

description: A morphologic variant of glioblastoma characterized by the presence of a highly proliferative and monotonous population of malignant small glial cells.


Acquired Hypogonadotropic Hypogonadism

description: Hypogonadotropic hypogonadism, the cause of which is not present from birth.


name: Metastatic Urethral Urothelial Carcinoma

description: A urethral urothelial carcinoma that has spread to another anatomical site.


Childhood Appendix Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the appendix during childhood. It is usually located in the tip of the appendix. The vast majority of cases are grade 1 neuroendocrine tumors.


Childhood Lymphoma by AJCC v8 Stage

description: Staging systems for Hodgkin and non-Hodgkin lymphomas of childhood. Different systems are used for Hodgkin lymphoma and non-Hodgkin lymphoma of childhood. Staging of childhood Hodgkin lymphoma is the same as for the adult counterpart and is based on the Lugano classification criteria. The Ann Arbor staging system has been found to be inappropriate for staging of the non-Hodgkin lymphomas of childhood. The St. Jude staging system has been widely accepted and remains the recommended staging system for non-Hodgkin lymphomas of childhood. (from AJCC 8th Ed.)


Hypoglossal Nerve Palsy

description: Partial or complete paralysis of the hypoglossal nerve.


name: Metastatic malignant neoplasm to extrahepatic bile ducts

description: A malignant neoplasm that has spread to the extrahepatic bile ducts from another anatomic site.  Representative examples include metastatic melanoma and metastatic breast and gastric carcinomas.


name: Cutaneous epithelioid angiomatoid nodule

description: A distinctive benign cutaneous vascular proliferation with prominent epithelioid morphology. It appears to be reactive. (WHO 2018)


Stage IIIC Cervical Cancer AJCC v9

description: Stage IIIC includes: IIIC1: TX, T0, T1-3, N1, M0; IIIC2: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes.  M0: No distant metastasis. (from AJCC 9th Ed.)


Cervical Microglandular Hyperplasia

description: A benign endocervical gland proliferation characterized by the presence of closely packed glands composed of columnar to cuboidal cells with subnuclear mucin vacuoles. It is associated with progestins or pregnancy.


name: immune effector cell-associated neurotoxicity syndrome, grade 3

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0, 1, or 2 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of greater than or equal to 9 (for children 12 and under), the ability of the affected individual to awaken only to tactile stimulus, clinical focal or generalized seizures that resolve rapidly, or non-convulsive seizures detected by electroencephalography (EEG) that resolve with intervention, and local cerebral edema evident on neuroimaging.


name: Extrahepatic Bile Duct Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The Ki-67 index is higher than 20%.


name: Ampulla of Vater Somatostatin-Producing Neuroendocrine Tumor

description: A well differentiated neuroendocrine tumor that arises from the ampulla of Vater and the periampullary region.  It produces somatostatin.


Recurrent Adenoid Cystic Carcinoma

description: The reemergence of adenoid cystic carcinoma after a period of remission.


Catheter related infection

description: An infection that arises secondary to catheter use.


Locally Advanced Cervical Carcinoma

description: A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Unresectable Plexiform Neurofibroma

description: Plexiform neurofibroma that is not amenable to surgical resection.


Prostate Cancer by AJCC v8 Stage

description: A term that refers to the staging of prostate cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to adenocarcinomas and squamous cell carcinomas of the prostate gland. It does not apply to sarcomas, urothelial cell carcinomas, and urothelial carcinoma of bladder involving prostate. (from AJCC 8th Ed.)


Abnormal Finding on Diagnostic Imaging

description: An observation made during diagnostic imaging that is outside the parameters considered normal.


Locally Recurrent Carcinoma

description: The reemergence of carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Advanced Transitional Cell Carcinoma

description: Transitional cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Refractory Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that is resistant to treatment.


name: Immune Checkpoint Inhibitor-Induced Dermatitis

description: Dermatitis associated with the therapeutic use of an immune checkpoint inhibitor.


Benign Supratentorial Neoplasms

description: A neoplasm that arises from above the cerebellar tentorium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Desmoplastic Myxoid Tumor of the Pineal Region, SMARCB1-Mutant

description: A SMARCB1-deficient tumor of the brain arising in the pineal region. It is characterized by the presence of spindled and epithelioid cells with low-grade morphology that are embedded in a desmoplastic stroma alternating with various extents of loose myxoid matrix.


name: Platinum-Resistant Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that progresses between one and six months of completing platinum therapy.


name: Lymphomatoid Papulosis with DUSP22-IRF4 Gene Rearrangement

description: A variant of lymphomatoid papulosis associated with chromosomal rearrangements involving the DUSP22-IRF4 locus at 6p25.3.


name: Stage IIB Cervical Cancer AJCC v6 and v7

description: Stage IIB includes: T2b, N0, M0.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive

description: The reemergence of chronic myeloid leukemia, BCR-ABL1 positive after a period of remission.


Disorder of AMH

description: Abnormally high or low anti-Müllerian hormone levels.


Childhood Gastroblastoma

description: A gastroblastoma that occurs during childhood.


name: Drug and toxin-induced pulmonary arterial hypertension

description: A rare, progressive disorder characterized by abnormally high blood pressure in the pulmonary artery caused by obstruction and obliteration of the small pulmonary arteries due to drugs or toxins. The stimulant appetite suppressant aminorex fumarate and other stimulant anorectics such as the serotonin reuptake inhibitor dexfenfluramine, as well as other agents, including illegal substances have been reported as causative agents.


name: Squamous cell carcinoma with horn formation

description: A keratinizing squamous cell carcinoma characterized by the presence of horn pearls. Representative examples include squamous cell carcinomas of the face presenting as a cutaneous horn.


Hamartoma of brain

description: A hamartoma that occurs in the brain.


name: Congenital Reproductive System Abnormality

description: A disorder that affects the female or male reproductive system and is present at birth. Representative examples include ovarian agenesis, vaginal agenesis, and penile agenesis.


name: Secondary Central Nervous System Hodgkin Lymphoma

description: A Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site.


name: Refractory Primary Central Nervous System Neoplasm

description: A primary central nervous system neoplasm that is resistant to treatment.


name: Prostate Ductal Adenocarcinoma, Solid Pattern

description: A prostate ductal adenocarcinoma characterized by the presence of cribriform and/or papillary patterns and areas of solid nests of malignant cells.


Parapharyngeal abscess

description: An abscess that develops in the soft tissues of the lateral pharyngeal space.


Chemical peritonitis

description: A non-infectious inflammation of the peritoneum.


Locally Advanced Ocular Melanoma

description: Ocular melanoma that has spread from its original site of growth to nearby tissues.


name: Refractory Malignant Leptomeningeal Neoplasm

description: Malignant leptomeningeal neoplasm that is resistant to treatment.


Bone Cancer by AJCC v8 Stage

description: A term that refers to the staging of appendicular skeleton, trunk, skull, and facial bones cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to osteosarcoma, chondrosarcoma, Ewing sarcoma, spindle cell sarcoma, hemangioendothelioma, angiosarcoma, fibrosarcoma/myofibroid sarcoma, chordoma, adamantinoma, and other cancers arising in the bone. It does not apply to primary malignant lymphoma of the bone and multiple myeloma. There are no AJCC prognostic stage groupings for spine and pelvis. (from AJCC 8th Ed.)


name: Lugano Classification Stage IV Childhood Hodgkin Lymphoma AJCC v8

description: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or noncontiguous extralymphatic organ involvement in conjunction with nodal stage II disease; or any extralymphatic organ involvement in nodal stage III disease. Stage IV includes any involvement of the bone marrow, liver, or lungs (other than by direct extension in stage IIE disease). (from AJCC 8th Ed.)


name: Low Grade Fallopian Tube Serous Adenocarcinoma

description: A slow-growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.


name: Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma

description: The reemergence of low grade fallopian tube serous adenocarcinoma after a period of remission.


name: Mitochondrial Pyruvate Carrier Deficiency

description: An autosomal recessive condition caused by mutation(s) in the MPC1 gene, encoding mitochondrial pyruvate carrier 1. it is characterized by lactic acidosis with a normal lactate/pyruvate ratio, and global developmentally.


Minimal Deviation Melanoma

description: A melanocytic neoplasm displaying morphologic features that are intermediate between those of benign nevus and melanoma.  It is characterized by a nodular architectural growth resembling a melanoma, and a loss of nevus cell maturation.  The melanocytic cells forming the nodular growth are uniform, and they may display a high mitotic rate, but they do not show cytologic atypia.


Adult Benign Cerebral Neoplasm

description: A benign neoplasm of the cerebrum occurring in adults.


Stage IIA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and measuring more than 4 cm in diameter. (FIGO 2009)


name: Prostate Acinar Pleomorphic Giant Cell Adenocarcinoma

description: An extremely rare prostate acinar adenocarcinoma characterized by the presence of giant, bizarre anaplastic cells with pleomorphic nuclei and lack of a spindle cell component.


name: FIGO Stage IVA Gestational Trophoblastic Tumor


Cusp tear

description: A split located on a leaflet of a heart valve that prevents its complete closing, which can result in valvular dysfunction.


Disturbance in mood

description: A change in disposition or state of mind.


name: Papillary squamous cell carcinoma, non-invasive

description: A well differentiated squamous cell carcinoma characterized by a papillary, exophytic growth pattern, hyperkeratosis, and absence of invasion of adjacent tissues.


name: Ampullary Noninvasive Pancreatobiliary Papillary Neoplasm with Low Grade Dysplasia

description: An ampullary noninvasive papillary neoplasm of the pancreatobiliary type characterized by the presence of low grade dysplasia.


Viral endocarditis

description: Endocarditis caused by a viral infection.


name: Refractory Neoplastic Post-Transplant Lymphoproliferative Disorder

description: Neoplastic post-transplant lymphoproliferative disorder that is resistant to treatment.


AHL Amyloidosis

description: An extremely rare type of amyloidosis characterized by the monoclonal deposition of immunoglobulin heavy chain and light chain fragments in organs and tissues.


Bone Rosai-Dorfman-Destombes Disease

description: Rosai-Dorfman-Destombes disease affecting the bone.


name: Subarachnoid Hemorrhage Related to Birth

description: Bleeding within the subarachnoid space occurring during labor and/or delivery.


name: Unresectable Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that is not amenable to surgical resection.


name: Neoplasm, malignant, uncertain whether primary or metastatic

description: A malignant neoplasm in which the examined tissue can not be determined with certainty if it represents the primary site of tumor growth or tumor spread from another anatomic site.


Non-Neoplastic Brain Disorder

description: A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis.


Stage II Bone Sarcoma AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Unresectable Urethral Urothelial Carcinoma

description: Urethral urothelial carcinoma that is not amenable to surgical resection.


name: Stage I Appendix Neuroendocrine Tumor AJCC v7

description: Stage I includes: T1, N0, M0. T1: Tumor 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder

description: An early lesion of post-transplant lymphoproliferative disorder with the morphologic appearance of florid follicular hyperplasia.


Malignant Hair Follicle Neoplasm

description: A neoplasm that arises from the hair follicle and metastasizes to other anatomic sites.


name: Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8

description: Stage IIIB includes: T1-4, N1b-3, M0. T1: Maximum clinical tumor diameter equal to or less than 2 cm. T2: Maximum clinical tumor diameter more than 2 cm but equal to or less than 5 cm. T3: Maximum clinical tumor diameter more than 5 cm. T4: Primary tumor invades fascia, muscle, cartilage, or bone. N1b: Clinically and/or radiologically detected regional lymph node metastasis, microscopically confirmed. N2: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis. N3: In-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) with lymph node metastasis. M0: No distant metastasis detected on clinical and/or radiologic examination. (AJCC 8th ed.)


name: Acute promyelocytic leukemia - hypogranular variant

description: Acute promyelocytic leukemia in which the promyelocytes in the peripheral blood have paucity or absence of cytoplasmic granules and characteristic bilobed nuclei.


name: Locally Advanced Digestive System Neuroendocrine Tumor

description: A digestive system neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Infarction of brain due to migraine

description: Migraine associated with an ischemic brain lesion.


name: Prostate Acinar Oncocytic Adenocarcinoma

description: An exceptionally rare acinar prostate adenocarcinoma characterized by the presence of malignant large cells with granular eosinophilic cytoplasm.


name: Meningeal Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: Infiltration of the meninges by chronic myeloid leukemia, BCR-ABL1 positive.


name: Stage IV Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Congenital listeriosis

description: A bacterial infection by Listeria monocytogenes that is present at birth.


Mullerian Papilloma

description: A benign papillary neoplasm that arises from the cervix or vagina. It mostly occurs in prepubertal girls and rarely in adolescents or young adults. It is characterized by the presence of a fibrovascular core covered by cuboidal or columnar epithelial cells. Squamous metaplasia may be present. Cytologic atypia is absent.


Contact dermatitis caused by alkali

description: Contact dermatitis caused by exposure to alkalis.


Adult Diffuse Large Cell Lymphoma

description: A B-or T-cell non-Hodgkin lymphoma composed of a diffuse large cell lymphocytic infiltrate occurring in adults.


Aplastic anemia due to radiation

description: Aplastic anemia caused by excessive absorption of radiation by the bone marrow.