name: Clinical Stage IIB Cutaneous Melanoma AJCC v8

description: Stage IIB includes: (T3b, N0, M0); (T4a, N0, M0). T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Locally Advanced Basal Cell Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A basal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Brain Ependymoma

description: An ependymoma that arises from the brain.


name: T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

description: A T-cell prolymphocytic leukemia characterized by the presence of neoplastic prolymphocytes with irregular or cerebriform nuclear outline.


Gliomatosis Cerebri Type II

description: A classic form of gliomatosis cerebri. It is characterized by diffuse growth of neoplastic glial tissue without any focal mass.


Adnexal Secretory Carcinoma

description: A rare adnexal carcinoma that is histopathologically identical to homologous lesions in the salivary gland and breast. (WHO 2018)


description: Decreased or absent activity of the enzyme 17-alpha-hydroxylase/17,20 lyase due to loss-of-function mutation(s) in the CYP17A1 gene. The clinical manifestations of the deficiency are dependent on whether one or both activities of the enzyme are affected, and may include hypertension due to reduced 17-hydroxylase activity and incomplete genital masculinization in 46,XY infants due to reduced 17,20 lyase activity.


Malignant hepatobiliary neoplasms

description: A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder.  Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Stage III Bladder Cancer AJCC v8

description: Stage III includes: IIIA: (T3a, T3b, T4a, N0, M0); (T1-T4a, N1, M0); IIIB: (T1-T4a, N2, N3, M0). T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T3a: Tumor invades perivesical soft tissue, microscopically. T3b: Tumor invades perivesical soft tissue, macroscopically (extravesical mass). T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node). N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Temporal lobe sclerosis

description: A neurological condition caused by scarring and degeneration of the temporal lobe. It is characterized by cognitive and behavioral symptoms, and focal epilepsy.


Proliferative retinopathy

description: Retinopathy characterized by the formation of new vessels in the retina. The new vessels are abnormal and fragile. If hemorrhage occurs due to the vascular fragility, there is increased risk of vision loss or blindness.


Neonatal aspiration of amniotic fluid

description: Inhalation of fluid from the amniotic sac into the lungs by the neonate.


Childhood Perineurioma

description: A perineurioma that occurs during childhood.


Acquired postural kyphosis

description: Postural kyphosis, the cause of which is not present at birth.


name: Arterial Calcification due to Deficiency of CD73

description: An autosomal recessive condition caused by mutation(s) in the NT5E gene, encoding 5'-nucleotidase. Deficiency in this enzyme (also know as CD73 antigen) results in arterial calcification of the lower extremities, and the joints affecting the hands and feet.


squamous cell papilloma of anal canal

description: A benign epithelial neoplasm that arises from the anal canal.  It is characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy.


name: Refractory Fallopian Tube Undifferentiated Carcinoma

description: Fallopian tube undifferentiated carcinoma that is resistant to treatment.


name: Steroid Resistant Chronic Graft Versus Host Disease

description: Chronic graft versus host disease that is resistant to treatment with steroids.


name: Recurrent Epithelioid Malignant Peripheral Nerve Sheath Tumor

description: The reemergence of an epithelioid malignant peripheral nerve sheath tumor after a period of remission.


name: Stage II Gestational Trophoblastic Tumor AJCC v7

description: Stage II includes: (T2, M0, Risk factors: unknown); IIA (T2, M0, Risk factors: low risk); IIB (T2, M0, Risk factors: high risk).  T2: Tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension.  M0: No distant metastasis.  (AJCC 7th ed.)


Anemia (mild)

description: Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%.


name: clear cell adenocarcinoma of urinary tract

description: An adenocarcinoma that arises from the urinary tract and is characterized by the presence of malignant cells with clear and eosinophilic cytoplasm arranged in tubulo-cystic, papillary, or solid growth patterns. It usually arises from the urethra but can also occur in the bladder. It predominantly affects females and usually has an aggressive clinical course.


Stage I Childhood Large Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Intraocular Schwannoma

description: A benign schwannoma occurring in the eye.


Recurrent Childhood Lymphoma

description: The reemergence of a childhood Hodgkin or non-Hodgkin lymphoma after a period of remission.


Neurocysticercosis

description: A parasitic infection with tapeworms of the genus Taenia affecting the brain. It is manifested with seizures and headaches.


description: A pilomyxoid astrocytoma occurring in the hypothalamic-chiasmatic region.


Relapsing classical Hodgkin lymphoma

description: The reemergence of classic Hodgkin lymphoma after a period of remission.


Borderline Fallopian Tube Serous Tumor

description: A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion.


name: Refractory Mature T-Cell and NK-Cell Neoplasm

description: Mature T-cell and NK-cell neoplasm that is resistant to treatment.


name: Stage IVB Childhood Hodgkin Lymphoma by Toronto Guidelines v2

description: Diffuse or disseminated (multifocal) involvement of one or more extra-lymphatic organs with or without associated lymph node involvement or isolated (non-contiguous) extra-lymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s) or any involvement of liver, bone marrow, lungs (except by direct extension from another site) or CSF. The medical record states there are constitutional symptoms. This definition applies to both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Rhesus hemolytic disease of newborn

description: A disorder caused when there is a Rh-factor blood-type incompatibility between the mother and fetus, and the mother's immune system forms antibodies that attack the red blood cells of her unborn child. This disorder can only occur if the mother is Rh-negative and the fetus is Rh-positive.


name: Recurrent High Grade Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial high-grade endometrioid adenocarcinoma after a period of remission.


Old myocardial infarction

description: Documented history of previous myocardial infarction (MI), typically with objective evidence via positive biomarkers of myocardial necrosis.


Acquired macrocephaly

description: A non-congenital condition in which the head circumference is two standard deviations greater than the mean. Causes include infection, intraventricular hemorrhage, subdural hematoma, and arachnoid cysts.


Infective cervicitis

description: An infectious process affecting the uterine cervix. Causative agents include Neisseria gonorrhoeae, Chlamydia trachomatis, human papillomavirus, and herpes simplex virus. Physical examination reveals an erythematous, raised lesion in the cervix and mucopurulent discharge.


Crypt abscess (morphologic abnormality)

description: Accumulation of polymorphonuclear neutrophils in the mucosal crypts of the colon. It occurs in ulcerative colitis.


Intraductal Hyperplasia

description: A hyperplasia of the intraductal cells.


name: Invasive Sarcomatoid Urothelial Carcinoma

description: An invasive urothelial carcinoma that exhibits spindle cell sarcomatoid features.


pathologic fistula

description: Abnormal epithelial-lined communication between two anatomical structures.


Hypersexualism

description: Excessive sexual behavior.


Refractory Acute Leukemia

description: Acute leukemia that does not respond to treatment.


name: Alcohol Related Neurodevelopmental Disorder

description: A cognitive and neurological disorder due to fetal intrauterine exposure to maternal alcohol consumption. Typically, this presents without facies or other growth abnormalities.


High Grade Endometrial Carcinoma

description: A group of aggressive endometrial carcinomas with high-grade histological features. It includes high grade endometrial endometrioid adenocarcinoma, endometrial clear cell adenocarcinoma, endometrial serous adenocarcinoma, and endometrial undifferentiated carcinoma.


description: An epithelioid hemangioendothelioma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Genital leukoplakia

description: A clinical term used to describe hyperkeratotic epithelial white patches of the genital mucous membranes.--2004


name: Juvenile Myelomonocytic Leukemia-Like Neoplasm

description: A myeloid neoplasm that resembles juvenile myelomonocytic leukemia by clinical and hematologic criteria but lacks mutations of the RAS pathway. Secondary mutations may be present.


Liver Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the liver. The mitotic count is 2-20 per 10 HPF.


name: Invasive Poorly Differentiated Urothelial Carcinoma

description: Invasive urothelial carcinoma that lacks the morphological features indicating urothelial origin. Immunohistochemical studies are required to demonstrate the urothelial lineage in these tumors.


name: Diffuse malignant lymphoma - large cleaved cell

description: Antiquated term describing non-Hodgkin lymphomas that are usually diffuse and are composed of large cells with irregular nuclei, invisible nucleoli and a small amount of cytoplasm.  This morphologic category includes both mature B- and mature T-cell lymphomas.


Stage I Bladder Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Pseudomonas-Related Vasculitis

description: A necrotizing vasculitis caused by Pseudomonas aeruginosa.


Vaginal adenocarcinoma metastatic

description: An adenocarcinoma that arises from the vagina and has metastasized to other anatomic sites.


Physical addiction

description: The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered.


name: Stage III Cervical Cancer AJCC v6 and v7

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T1, N1, M0), (T2, N1, M0), (T3a, N1, M0), (T3b, Any N, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non functioning kidney.  N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Mixed Phenotype Acute Leukemia, Rare Types

description: A very rare mixed phenotype acute leukemia in which the blasts express combinations of B, T, myeloid, and megakaryocytic lineage markers but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation. The prognosis is usually unfavorable.


description: A lymphoproliferative disorder caused by the human herpesvirus 8 (HHV8). This category includes the following: HHV8-positive multicentric Castleman disease; HHV8-positive diffuse large B-cell lymphoma, not otherwise specified; primary effusion lymphoma; and germinotropic lymphoproliferative disorders.


Diverticulum

description: A pouch formed at a weakened area of wall in a hollow organ structure.


name: Unresectable Ureter Urothelial Carcinoma

description: Ureter urothelial carcinoma that is not amenable to surgical resection.


Fredrickson Type III lipidaemia

description: A laboratory test result indicating an inheritable form of dysbetalipoproteinemia, in which there are excess intermediate-density lipoproteins in the blood.


description: A subtype of myelodysplastic syndrome which initially lacks findings appropriate for classification into any other myelodysplastic category.  There are no specific morphologic findings.  The diagnosis can be made in the following instances: 1. in cases of refractory cytopenia with unilineage dysplasia or refractory cytopenia with multilineage dysplasia but with 1% blasts in the peripheral blood; 2: in cases of myelodysplastic syndrome with unilineage dysplasia which are associated with pancytopenia; 3: in cases with persistent cytopenia (s) with 1% or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10% of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome. (WHO, 2008)


Stage IVA Prostate Cancer AJCC v8

description: Stage IVA includes: Any T, N1, M0, PSA: Any, Grade Group: Any. N1: Prostate cancer with metastases in regional node(s). M0: Prostate cancer without evidence of distant metastasis. (AJCC 8th ed.)


name: Stage 0 Digestive System Neuroendocrine Tumor AJCC v7

description: Stage 0 includes: Tis, N0, M0.  Tis (applies only to stomach): Carcinoma in situ/dysplasia (tumor size less than 0.5 mm), confined to mucosa. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Juvenile Dermatomyositis Sine Myositis

description: A rare form of juvenile dermatomyositis that manifests with characteristic cutaneous findings for at least six months in the absence of any detectable muscle involvement.


Advanced Cutaneous Melanoma

description: Cutaneous melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Metastatic malignant neoplasm to brain

description: A malignant neoplasm that has spread to the brain from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


Hallucinogen dependence, episodic

description: Physical and psychological dependence on hallucinogenics, which is associated with a pattern of episodic use.


name: Stage IIA Ampulla of Vater Cancer AJCC v7

description: Stage IIA includes: T3, N0, M0.  T3: Tumor invades the pancreas.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Refractory Myelofibrosis

description: Myelofibrosis that is resistant to treatment.


name: Childhood Acute Lymphoblastic Leukemia Toronto Guidelines v2, Tier 1

description: A term that refers to the staging of childhood acute lymphoblastic leukemia according to the tier 1 Toronto childhood cancer staging guidelines v2.


Metastatic Fallopian Tube Carcinoma

description: A carcinoma that arises from the fallopian tube and has metastasized to another anatomic site.


Proliferative Actinic Keratosis

description: Actinic keratosis characterized by the presence of dermal projections of nested atypical keratinocytes and dense dermal inflammation.


name: Monoclonal Gammopathy of Renal Significance

description: A condition caused by a B-cell or plasma cell clone resulting in the deposition of the secreted monoclonal immunoglobulin, without evidence for overt lymphoma or myeloma. This category includes a wide spectrum of renal pathology and include such lesions as immunoglobulin-associated amyloidosis, the monoclonal immunoglobulin deposition diseases (MIDDs; light chain deposition disease, heavy chain deposition disease, and light and heavy chain deposition disease), proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID), C3 glomerulopathy with monoclonal gammopathy, light chain proximal tubulopathy (Fanconi syndrome), and several others.


name: Unresectable Malignant Digestive System Neoplasm

description: A malignant digestive system neoplasm that is not amenable to surgical resection.


name: Melanoma in Chronically Sun-Exposed Skin

description: A melanoma that arises from a chronically sun-exposed skin area. It is associated with severe actinic keratosis.


Exaggerated placental site

description: A non-neoplastic trophoblastic disorder characterized by the presence of an increased number of implantation-site intermediate trophoblasts infiltrating the endometrium and myometrium extensively. It is associated with pregnancy or abortion.


Stage III Esophageal Cancer

description: Stage III includes: T3, N1, M0 and T4, Any N, M0) T3: Tumor invades adventitia. T4: Tumor invades adjacent structures. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) -2003


name: Stage IV Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis.  (AJCC 7th ed.)


name: Stage I Digestive System Neuroendocrine Tumor AJCC v7

description: Stage I includes: T1, N0, M0.  T1: Stomach: tumor invades lamina propria or submucosa and is 1 cm or less in size; duodenum /jejunum/ileum: tumor invades lamina propria or submucosa and is 1 cm or less in size; ampulla: tumor 1 cm or less; colon or rectum: tumor invades lamina propria or submucosa and is 2 cm or less.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Neonatal encephalopathy

description: Abnormal functioning of the central nervous system in the newborn period that may be due to a variety of etiologies including hypoxia/ischemia, metabolic disturbance, or infection.


Pre-Pre-B Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia of early B-lineage.


name: Advanced Pancreatic Neuroendocrine Neoplasm

description: A pancreatic neuroendocrine neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Common blue nevus of skin

description: A blue nevus that is not associated with increased cellularity.


Neuromuscular hamartoma

description: A very rare intraneural mass in a large nerve characterized by the interposition of mature skeletal muscle fibers and nerve fibers.


Metastatic Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that has spread to another anatomical site.


name: Metastatic Malignant Peripheral Nerve Sheath Tumor

description: The presence of malignant Schwann cell growth (benign variant is known as neurofibroma) at a site removed from the primary site of tumor growth.


undifferentiated carcinoma of cervix

description: A rare carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation.


name: Refractory Non-Muscle Invasive Bladder Urothelial Carcinoma

description: Non-muscle invasive bladder urothelial carcinoma that is resistant to treatment.


name: Adult Mixed Cellularity Classical Hodgkin Lymphoma

description: Mixed cellularity classic Hodgkin lymphoma occurring in adults.


Prostate Neuroendocrine Tumor

description: An extremely rare, slow-growing well-differentiated neuroendocrine neoplasm that affects the prostate gland.


name: Acute Myelomonocytic Leukemia without Abnormal Eosinophils

description: Acute myelomonocytic leukemia without an abnormal eosinophilic component in the bone marrow.


Acquired Factor XII Deficiency

description: An acquired coagulation disorder characterized by the partial or complete absence of factor XII activity in the blood.


name: Diffuse Laminar Endocervical Hyperplasia

description: A benign band-like proliferation of tightly-packed, small to medium sized endocervical glands below the surface of the endocervical canal.


Mesenteric abscess

description: An abscess that is located in any part of the tissue composing the mesentery, and that generally arises from an infection in an adjacent area of the intestine.


name: Acute Myeloid Leukemia with U2AF1 Mutation

description: An acute myeloid leukemia associated with U2AF1 gene mutation.


Subungual Melanoma

description: A melanoma that arises from the area underneath a fingernail or toenail. It affects the fingernails more often than the toenails.


Refractory Erdheim-Chester Disease

description: Erdheim-Chester disease that does not respond to treatment.


Stage IV Cervical Cancer AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Stage IIIB Vulvar Cancer AJCC v8

description: Stage IIIB includes: T1-T2, N2a, N2b, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N2a: Three or more lymph node metastases each less than 5 mm. It includes micrometastasis, N2mi. N2b: Two or more lymph node metastases equal to 5 mm. M0: No distant metastasis. (AJCC 8th Ed.)


Benzene-Related Acute Myeloid Leukemia

description: Acute myeloid leukemia caused by benzene.


Stage IV Gastric Cancer with Metastasis

description: T4,N2,MO (from PDQ)


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 6

description: Dyskeratosis congenita caused by autosomal recessive mutation(s) in the PARN gene, encoding poly(A)-specific ribonuclease PARN.


name: Acute on chronic diastolic heart failure

description: Acute decompensation of chronic diastolic congestive heart failure.


Benign Paratesticular Neoplasm

description: A neoplasm that arises from the paratesticular structures and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Neonatal respiratory system disorder

description: A respiratory system disorder that occurs during the neonatal period. A representative example is the respiratory distress syndrome.


Penile Infection

description: An infectious process affecting the penis.


Oral Multifocal Epithelial Hyperplasia

description: Benign multifocal squamous epithelial proliferation affecting the oral mucosa. It is associated with human papilloma virus infection.


Syringomyelia and Hydromyelia

description: Syringomyelia associated with accumulation of cerebrospinal fluid in the spinal cord.


Palsy of vagus nerve

description: Partial or complete paralysis of the vagus nerve.


Facial Nerve Palsy Related to Birth

description: A condition characterized by reduced or absent movement of the ipsilateral face as a consequence of an injury to the seventh cranial nerve sustained during the birthing process.


name: FIGO Stage IIIC Gestational Trophoblastic Tumor


name: Squamous cell carcinoma, clear cell type

description: A squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm.


name: Transitional cell cancer of renal pelvis and ureter metastatic

description: A urothelial carcinoma of the renal pelvis and ureter that has spread from its original site of growth to another anatomic site.


Broad Ligament Ependymoma

description: A rare neoplasm that arises from the broad ligament and shows ependymal differentiation.


Appendix Serrated Lesions and Polyps

description: Polyps that arises from the appendix. They are characterized by the presence of serrated glands and the absence of generalized dysplasia.


Recurrent Neuroendocrine Carcinoma

description: The reemergence of neuroendocrine carcinoma after a period of remission.


COVID-19-Associated Ataxia

description: Ataxia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Spitz Tumor

description: A term that refers to a group of melanocytic neoplasms that are composed of epithelioid and/or spindle cells and extend from the epidermis into the reticular dermis, often in a wedge-shaped configuration. They are usually associated with oncogenic mutations that activate the MAP-kinase pathway. This category includes Spitz nevus, Spitz melanocytoma, and Spitz melanoma.


Childhood Granular Cell Tumor

description: A granular cell tumor that occurs during childhood.


Atypical meningioma

description: A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis.


Stage IVA Osteosarcoma AJCC v7

description: Stage IVA includes: Any T, N0, M1a, Any G.  N0: No regional lymph node metastasis.  M1a: Distant metastasis to lung. (AJCC 7th ed.)


Resectable Astrocytoma

description: An astrocytoma that is amenable to surgical resection.


name: Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm

description: An acute myeloid leukemia developing in patients with a prior history of myeloproliferative neoplasm.


Cardiac tuberculosis

description: Tuberculosis affecting the heart.


Post-Mastectomy Pain Syndrome

description: Chronic pain following mastectomy or lumpectomy that usually affects the anterior thorax, axilla, and/or medial upper arm.


name: Myxoid Glioneuronal Tumor of the Septum Pellucidum

description: A myxoid glioneuronal tumor that arises from the septum pellucidum.


Refractory Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that does not respond to treatment.


Childhood Fibrous Dysplasia

description: Fibrous dysplasia that occurs during childhood.


Hypertrophic Actinic Keratosis

description: Actinic keratosis characterized by the presence of epidermal hyperplasia, parakeratosis, and orthokeratosis.


name: Refractory Anaplastic Pleomorphic Xanthoastrocytoma

description: Anaplastic pleomorphic xanthoastrocytoma that is resistant to treatment.


name: Idiopathic Cytopenias of Undetermined Significance

description: Cytopenia in one or more hematopoietic cell lineages that remains unexplained following thorough evaluation. The hematopoietic cell dysplasia is mild and does not fulfill the criteria for myelodysplastic syndrome, but the cytopenia may be severe. There is no evidence of clonal hematopoiesis or the variant allele frequency (VAF) is less that 2 percent. There is no other evidence of hematologic malignancy. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder.


name: Hodgkin's disease mixed cellularity stage III

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


name: Recurrent Appendix Mucinous Adenocarcinoma

description: The reemergence of appendix mucinous adenocarcinoma after a period of remission.


Lipoprotein(a) Quantitative Trait Locus

description: A metabolic disorder caused by polymorphisms in the LPA gene that affect the number of kringle-4 repeats in the encoded protein, apolipoprotein(a) (apo(a)). The number of kringle-4 repeats are inversely correlated with apo(a) expression in the blood. Thus, forms of apo(a) with fewer repeats are expressed at elevated levels, which leads to increased concentrations of apo(a)-containing lipoprotein particles and an elevated risk for atherosclerosis, cardiovascular disease, and coronary artery disease.


Benign squamous cell tumor

description: A non-metastasizing neoplasm composed of squamous cells. The neoplastic cells do not display malignant features.


Surface Osteoma

description: An osteoma that arises from the surface of the bone.


Endometriosis of thorax

description: A condition characterized by the presence of functioning endometrial tissue in the lung, pleura, chest wall, and/or diaphragm.


Micronodular adrenal hyperplasia

description: Adrenal hyperfunction associated with multiple bilateral adrenal nodules, usually less than one centimeter in diameter.


name: Stage I Acral Lentiginous Melanoma AJCC v7

description: Stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2a, N0, M0).  T1a: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, without ulceration and mitosis less than 1/mm2.  T1b: Cutaneous melanoma with a tumor measuring 1.0 mm or less in thickness, with ulceration or mitoses equal to or more than 1/mm2. T2a: Cutaneous melanoma with a tumor measuring 1.01-2.0 mm in thickness, without ulceration.  N0: No regional lymph node metastases.  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


JC virus infection

description: An infection that is caused by JC virus.


name: Intestinal Metaplasia of Bladder Urothelium


Resectable Malignant Mesothelioma

description: Malignant mesothelioma that is amenable to surgical resection.


name: Fistula of intestine, excluding rectum and anus

description: An abnormal connection between the intestine and another epithelial-lined structure, but that does not include the rectum or anus.


name: Pancreatic Undifferentiated Carcinoma with Rhabdoid Cells

description: An undifferentiated carcinoma that arises from the pancreas. It is characterized by the presence of rhabdoid cells.


name: Stage III Appendix Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N0, M0); (T4, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q

description: A rare acute myeloid leukemia that occurs in childhood and is characterized primarily by deletions of 5q.


name: Locally Advanced Skin Squamous Cell Carcinoma

description: A squamous cell carcinoma of the skin that has spread from its original site of growth to nearby tissues or lymph nodes.


endometritis following abortion

description: Endometritis that develops following an abortion.


name: Conjunctival Reactive Lymphoid Hyperplasia

description: A polyclonal proliferation of lymphoid tissue in the conjunctiva that typically occurs in young adults. It usually presents as a unilateral, red or orange, painless swelling and is probably caused by chronic antigen stimulation. (WHO 2018)


Supratentorial Glioblastoma

description: A glioblastoma that occurs in the supratentorial region.


Metastatic Malignant Germ Cell Tumor

description: A malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


Benign vascular neoplasm

description: A mesenchymal neoplasm that arises from vascular tissue usually of the skin. It is characterized by the presence of vascular channel formation and endothelial cells. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases.


name: Refractory Mixed Phenotype Acute Leukemia

description: Mixed phenotype acute leukemia that does not respond to treatment.


REVESZ SYNDROME (disorder)

description: An autosomal dominant form of dyskeratosis congenita, caused by mutation(s) in the TINF2 gene, encoding TERF1-interacting nuclear factor 2. It is a fatal disease associated with exudative retinopathy and bone marrow failure.


name: Anaemias due to disorders of glutathione metabolism

description: Anemia resulting from an abnormality of glutathione deficiency.


Stage IIB Merkel Cell Carcinoma AJCC v7

description: Stage IIB includes: T2/T3, cN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  cN0: No regional lymph node metastasis by clinical examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


Substance-Induced Sexual Dysfunction

description: A disorder characterized by clinically significant sexual dysfunction (including impaired desire, impaired arousal, impaired orgasm, or sexual pain) that is fully explained by substance use.


Pelvic Cancer

description: A primary or metastatic malignant neoplasm that affects the organs and structures of the pelvis.


name: Adult TdT Positive Acute Lymphoblastic Leukemia

description: TdT positive acute lymphoblastic leukemia that occurs during adulthood.


KATP-Associated Hyperinsulinism

description: Hyperinsulinism caused by non-functional beta-cell ATP-sensitive potassium channels due to inactivating mutation(s) in either the ABCC8 or KCNJ11 gene.


Third Ventricle Germinoma

description: A germinoma that arises from the third ventricle.


name: Stage IIA Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Liposarcoma recurrent

description: The reemergence of liposarcoma after a period of remission.


Neoplasm of Uncertain Histogenesis

description: A benign or malignant, primary or metastatic neoplasm with uncertain histogenesis.


name: Merkel Cell Polyoma Virus-Negative Merkel Cell Carcinoma

description: A Merkel cell carcinoma that is not associated with Merkel cell polyoma virus infection.


name: Refractory Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that is resistant to treatment.


Paratesticular Squamous Cell Carcinoma

description: An extremely rare squamous cell carcinoma that arises from the paratesticular structures.


Recurrent Myeloid Sarcoma

description: The reemergence of myeloid sarcoma after a period of remission.


name: Diffuse Glioneuronal Tumor with Oligodendroglioma-Like Features and Nuclear Clusters

description: A provisional tumor entity described in the supratentorial brain and characterized by a distinct DNA methylation profile and monosomy of chromosome 14. It is composed of small to medium-sized cells showing perinuclear oligodendroglioma-like haloes, scattered multinucleated cells, and nuclear clusters composed of large pleomorphic nuclei. Most cases have been reported in pediatric patients.


name: Treatment related acute myeloid leukaemia

description: An acute myeloid leukemia arising as a result of the mutagenic effect of chemotherapy agents and/or ionizing radiation.  (WHO, 2001)


Transitional cell carcinoma in situ

description: A lesion in which the surface epithelium of the bladder or the renal pelvis and ureter contains transitional cells which display malignant cytologic characteristics.  There is no evidence of stromal invasion.


name: Ann Arbor Stage IV AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.


name: Stage III Ampulla of Vater Neuroendocrine Tumor AJCC v8

description: Stage III includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor invading the visceral peritoneum (serosa) or other organs. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Aggressive Systemic Mastocytosis with an Associated Germ Cell Tumor

description: Aggressive systemic mastocytosis associated with a germ cell tumor.


Stage IIIC Appendix Carcinoma AJCC v7

description: Stage IIIC includes: Any T, N2, M0. N2: Metastasis in four or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Gallbladder Cancer AJCC v6

description: Stage III includes: (T4, Any N, M0).  T4: Tumor invades main portal vein or hepatic artery or invades multiple extrahepatic organs or structures. (AJCC 6th ed.)


name: Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIB includes: (T1, N1, M0, Any G); (T3, N0, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T3: Tumor invades adventitia. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Bartholin Gland Hyperplasia

description: Nodular/lobular proliferation of normal Bartholin gland tissue and ducts.


Acquired arteriovenous aneurysm

description: An arteriovenous fistula, the cause of which is not present at birth.


Bronchopleural Fistula

description: An abnormal communication between a bronchus and the pleural cavity.


Refractory Biliary Tract Carcinoma

description: Biliary tract carcinoma that is resistant to treatment.


Primary Raynaud Phenomenon

description: Raynaud phenomenon without a known underlying autoimmune disorder.


Gallbladder Mucinous Cystic Neoplasm

description: An epithelial, usually multiloculated neoplasm arising from the gallbladder. It occurs predominantly in females. Signs and symptoms include abdominal mass, abdominal pain, and jaundice. Morphologically, the cystic spaces are lined by columnar epithelium and contain mucinous or serous fluid.


Advanced Melanoma

description: Melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Finding by Cause

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: Prostate Adenocarcinoma without Neuroendocrine Differentiation

description: A prostate adenocarcinoma characterized by the absence of focal or diffuse neuroendocrine differentiation.


name: Metastatic Digestive System Neuroendocrine Tumor G1

description: Digestive system neuroendocrine tumor G1 that has spread to other anatomic sites.


Adenocarcinoma, Oxyphilic

description: An adenocarcinoma characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm (oncocytes). Representative examples include thyroid gland oncocytic follicular carcinoma, oncocytic breast carcinoma, and salivary gland oncocytic carcinoma.


Non-Neoplastic Uveal Disorder

description: A non-neoplastic disorder that affects the uvea.


name: Hodgkin's disease mixed cellularity recurrent

description: The reemergence of mixed cellularity classic Hodgkin lymphoma after a period of remission.


Pancreatic Acinar Cell Neoplasm

description: An epithelial neoplasm that arises from the exocrine pancreas.  It is characterized by the presence of neoplastic cells that resemble acinar cells and produce pancreatic exocrine enzymes.  The vast majority are carcinomas.


Lymphangiomatosis

description: A lymphangioma affecting several anatomic sites.


name: Metastatic Bladder Giant Cell Urothelial Carcinoma

description: Bladder giant cell urothelial carcinoma that has spread to another anatomic site.


Uveal prolapse

description: The protrusion of uveal tissue through an opening in the sclera.


Unresectable Melanoma

description: Melanoma which is not amenable to surgical resection.


Alcohol-Related Carcinoma

description: A carcinoma that is caused by alcohol abuse.


name: Retinoblastoma by AJCC v8 Clinical Stage

description: A term that refers to the clinical staging of retinoblastoma according to the American Joint Committee on Cancer, 8th edition.


Chronic pulmonary embolism

description: Persistent and long-standing pulmonary embolism.


name: Intermediate Grade B-Cell Non-Hodgkin's Lymphoma


Liver Non-Epithelial Neoplasm

description: A benign or malignant non-epithelial neoplasm that affects the liver.


name: undifferentiated carcinoma of anal canal

description: A usually aggressive malignant epithelial neoplasm that arises from the anal canal.  It is composed of malignant cells which do not display evidence of glandular or squamous differentiation.


Female Reproductive System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the female reproductive system. Representative examples include ovarian carcinoma, cervical carcinoma, and endometrial carcinoma.


name: Bile Duct Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts.  It is characterized by the presence of moderate atypia.


name: Invasive Bladder Poorly Differentiated Urothelial Carcinoma

description: Invasive bladder urothelial carcinoma that lacks the morphological features indicating urothelial origin. Immunohistochemical studies are required to demonstrate the urothelial lineage in these tumors.


Stage IIA Merkel Cell Carcinoma AJCC v7

description: Stage IIA includes: T2/T3, pN0, M0.  T2: Primary tumor greater than 2 cm but not more than 5 cm in maximum dimension.  T3: Primary tumor over 5 cm in maximum dimension.  pN0: No regional lymph node metastasis by pathologic examination.  M0: No distant metastasis.  (AJCC 7th Ed.)


name: Pathologic Stage IA Cutaneous Melanoma AJCC v8

description: Stage IA includes: (T1a, N0, M0); (T1b, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Stage IIB Gallbladder Cancer AJCC v8

description: Stage IIB includes: T2b, N0, M0. T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Metastatic Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: Clear cell (glycogen-rich) urothelial carcinoma that has spread to another anatomic site.


name: Recurrent Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

description: The reemergence of accelerated phase chronic myeloid leukemia, BCR-ABL1 positive after a period of remission.


Neonatal infectious disorder

description: An infectious disorder that occurs during the neonatal period. Representative examples include streptococcal infection, E.coli infection, and bacterial meningitis.


Resectable Glioblastoma

description: A glioblastoma that is amenable to surgical resection.


name: New Onset Atrial Flutter Related to COVID-19

description: Newly occurring atrial flutter in a patient with probable or confirmed acute COVID-19.


Locally Advanced Non-Cutaneous Melanoma

description: Non-cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Endometrial Mucinous Adenocarcinoma, Intestinal-Type

description: A rare mucinous adenocarcinoma arising from intestinal metaplasia of the endometrium.


Lichen planus-like keratosis

description: A benign intraepidermal squamoproliferative neoplasm characterized by irregular acanthosis, hyperkeratosis, parakeratosis, and prominent chronic inflammation.


Secondary malignant neoplasm of skin

description: The spread of a malignant neoplasm to the skin.  This may be from a primary skin malignant neoplasm, or from a malignant neoplasm at a distant site.


name: Stage I Centroblastic Follicular Lymphoma

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE).


name: Female Reproductive System Precancerous Condition

description: A precancerous lesion that arises from the female reproductive system. Representative examples include atypical endometrial hyperplasia, endometrial intraepithelial neoplasia, and cervical intraepithelial neoplasia.


Primary Bone Hodgkin Lymphoma

description: An exceedingly rare Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement.


Arthritis NOS aggravated

description: Exacerbation of an arthritic condition.


name: Localized Pancreatic Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma that has not spread to other anatomic sites.


Fusion-Positive Rhabdomyosarcoma

description: A rhabdomyosarcoma characterized by the presence of chromosomal translocation t(1;13)(p36;q14) that results in PAX7-FOXO1 gene fusion; or translocation t(2;13)(q35;q14) that results in PAX3-FOXO1 gene fusion.


Adult Anaplastic Astrocytoma

description: An astrocytoma occurring in adults that is characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


name: Developmental and Epileptic Encephalopathy 85 with or without Midline Brain Defects

description: An X-linked dominant subtype of developmental and epileptic encephalopathy caused by mutation(s) in the SMC1A gene,  encoding structural maintenance of chromosomes protein 1A.


name: Locally Advanced Digestive System Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from any part of the digestive system and has spread to nearby tissues or lymph nodes.


Factor XI Inactivation

description: Presence of inactivating antibodies to factor XI in the blood.


name: Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2 Stage, International Society of Pediatric Oncology (SIOP) Protocol

description: A term that refers to the staging of childhood malignant kidney neoplasms excluding renal cell carcinoma, according to the Toronto childhood cancer staging guidelines v2, International Society of Pediatric Oncology (SIOP) protocol. It is based on findings at surgery for patients who have received chemotherapy prior to surgery. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Extrahepatic Bile Duct Carcinoid Tumor

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the extrahepatic bile ducts. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


Vaginal Cancer by AJCC v7 Stage

description: A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 7th edition.


Pure Erythroid Leukemia

description: Acute erythroid leukemia characterized by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present.


Paratesticular Mucinous Cystadenoma

description: A rare mucinous cystadenoma that arises from the paratesticular structures.


Benign neoplasm of liver

description: A neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


H influenze type B Meningitis

description: Meningitis that is attributed to the bacteria H influenze type B.


Urothelial carcinoma ureter recurrent

description: The reemergence of ureter urothelial carcinoma after a period of remission.


Stage IA Testicular Cancer AJCC v8

description: Stage IA includes: pT1, N0, M0, S0. pT1: Testicular cancer which is limited to testis (including rete testis invasion) without lymphovascular invasion. N0: Testicular cancer with no regional lymph node metastasis. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. (AJCC 8th ed.)


Stage II Cervical Cancer AJCC v8

description: Stage II includes: T2, Any N, M0. T2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina. M0: No distant metastasis. (AJCC 8th Ed.)


Rhinocephaly

description: A congenital anatomic defect characterised by the presence of a proboscis-like nose located above the eyes, which are partially or completely fused.


name: Stage IV Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)


Condyloma acuminata of vulva

description: A benign human papillomavirus-related neoplasm that arises from the vulva. It is characterized by the presence of papillary structures with fibrovascular cores covered by stratified squamous epithelium showing koilocytotic changes.


name: Lugano Classification Stage IIE Adult Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: High Grade Anal Intraepithelial Neoplasia

description: Anal canal or perianal skin intraepithelial neoplasia with moderate or severe dysplasia.


Stage 0 Merkel Cell Carcinoma AJCC v7

description: Stage 0 includes: Tis, N0, M0.  Tis: In situ primary tumor.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Childhood Lymphocyte-Rich Classic Hodgkin Lymphoma

description: Lymphocyte-rich classic Hodgkin lymphoma occurring in childhood.


Recurrent Biliary Tract Carcinoma

description: The reemergence of a carcinoma arising from any part of the biliary tract after a period of remission.


name: Gallbladder Flat Biliary Intraepithelial Neoplasia

description: Biliary intraepithelial neoplasia that affects the gallbladder epithelium.  It is characterized by the absence of intraluminal micropapillary projections.


Midgut Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the jejunum, ileum, proximal colon, or appendix.


Chronic Bullous Disease of Childhood

description: A blistering disorder characterized by linear deposition of IgA at the dermoepidermal junction.


name: Myelodysplastic and myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis

description: A myelodysplastic/myeloproliferative neoplasm characterized by thrombocytosis, anemia, blasts less than 5% in bone marrow and less than 1% in peripheral blood, presence of SF3B1 gene mutation, absence of BCR/ABL fusion, absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions, and no history of other myelodysplastic/myeloproliferative neoplasms or myeloproliferative neoplasms and myelodysplastic syndromes.


Vaginal Cancer by AJCC v6 Stage

description: A term that refers to the staging of vaginal cancer according to the American Joint Committee on Cancer, 6th edition.


name: Cytogenetically Normal Acute Myeloid Leukemia Post Cytotoxic Therapy

description: Acute myeloid leukemia not associated with cytogenetic abnormalities and arising as a result of the mutagenic effect of chemotherapy and/or ionizing radiation.


name: Unresectable Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that is not amenable to surgical resection.


Childhood Grade II Meningioma

description: A grade II meningioma that occurs during childhood.


Periosteal Desmoid Tumor

description: A reactive, benign fibrous lesion that develops in the periosteum of the femur.  It usually affects boys and there is a history of trauma.  It is characterized by the formation of dense collagen tissue and reactive bone.


Stage IIB Testicular Cancer AJCC v8

description: Stage IIB includes: (Any pT/TX, N2, M0, S0); (Any pT/TX, N2, M0, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. M0: Testicular cancer without evidence of distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Bacterial Zoonoses

description: A bacterial infection that is transmitted from animals to people.


name: Mucosal Melanoma of the Genitourinary System

description: A malignant melanocytic neoplasm that arises from a mucosal site of the genitourinary system.


Bone Tuberculosis

description: Tuberculosis of the bone.


name: Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

description: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome.


Refractory Malignant Mastocytosis

description: Malignant mastocytosis that is resistant to treatment.


Recurrent Ependymoma

description: The reemergence of ependymoma after a period of remission.


Malposition of Ureter

description: Orientation of a ureter in an unusual anatomic location.


name: Glioblastoma with Primitive Neuronal Component

description: A glioblastoma characterized by the presence of well-demarcated nodules which contain primitive cells exhibiting neuronal differentiation.


Congenital Phrenic Nerve Palsy

description: Damage to the phrenic nerve that results in paralysis of the hemidiaphragm at birth.


Stage III Prostate Cancer AJCC v7

description: Stage III includes: T3a-b, N0, M0, Any PSA, Any Gleason.  cT3a: Tumor with extracapsular extension (unilateral or bilateral).  pT3a: Tumor with extraprostatic extension or microscopic invasion of bladder neck.  T3b: Tumor invades seminal vesicle(s).  cN0: No regional lymph node metastasis.  pN0: No positive regional nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Small Cell Glioblastoma

description: A small cell glioblastoma that is resistant to treatment.


name: FIGO Stage IC Gestational Trophoblastic Tumor


Stage IA Cervical Cancer AJCC v8

description: Stage IA includes: T1a, Any N, M0. T1a: Tumor diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IVB Bladder Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1b. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


Genetic anomaly of leukocyte

description: An abnormality of leukocytes, the cause of which is present from birth.


Squamous cell papilloma of eyelid

description: A papilloma that arises from the eyelid. It is composed of squamous cells and is characterized by the presence of an acanthotic epithelium with hyperkeratosis and papillary projections with an inner fibrovascular core. It is the most common benign epithelial tumor of eyelid. It usually affects middle-aged or older adults.


Ureter Cancer by AJCC v8 Stage

description: A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to ureter urothelial (transitional cell) carcinoma, including histologic variants micropapillary and nested subtypes. (from AJCC 8th Ed.)


Late-Onset Retinal Degeneration

description: An autosomal dominant condition caused by mutation in the C1QTNF5 gene, encoding complement C1q tumor necrosis factor-related protein 5. It is characterized by dark adaptation abnormalities, sub-retinal pigment epithelium lipid-rich material deposits, choroidal neovascularization, and chorioretinal atrophy. The typical onset is in the fifth or sixth decade of life.


Malignant neoplasm of stomach stage III

description: Stage III includes: IIIA (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0); IIIB (T4b, N0, M0); (T4b, N1, M0); (T4a, N2, M0); (T3, N3, M0); IIIC (T4b, N2, M0); (T4b, N3, M0); (T4a, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  T4b: Tumor invades adjacent structures. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


name: Lymphoma by Working Formulation (Antiquated)


Childhood Acute Leukemia

description: An acute leukemia that occurs during childhood.


Gastric Poorly Cohesive Adenocarcinoma

description: An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates.  This category includes signet ring cell adenocarcinomas, adenocarcinomas that are composed of malignant cells resembling lymphocytes and histiocytes, and adenocarcinomas that are composed of malignant cells with deeply eosinophilic cytoplasm.


Stage IIIA Gastric Carcinoma

description: Stage IIIA includes: (T4a, N1, M0); (T3, N2, M0); (T2, N3, M0).  T2: Tumor invades the muscularis propria. T3: Tumor penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures.  T4a: Tumor invades serosa (visceral peritoneum).  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.  (AJCC 7th ed.)


Stage III Bone Sarcoma AJCC v7

description: Stage III includes: T3, N0, M0, G3, G4. T3: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


Mitochondrial enzyme deficiency

description: A constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.


Stage IIIC1 Cervical Cancer AJCC v9

description: Stage IIIC1 includes: TX, T0, T1-3, N1, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. M0: No distant metastasis. (from AJCC 9th Ed.)


Lymphoma, Low-Grade

description: An antiquated term that refers to a non-Hodgkin lymphoma with low grade histologic features.


name: Radiation-Induced Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is the result of exposure to ionizing radiation.


Stage IIA Cervical Cancer AJCC v7

description: Stage IIA includes: IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0).  T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Childhood Benign Liver Neoplasm

description: A childhood neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Acantholytic Actinic Keratosis

description: Actinic keratosis characterized by the presence of acantholysis of the dysplastic keratinocytes.


name: Treatment-Related Prostate Neuroendocrine Carcinoma

description: A prostate carcinoma with partial or complete neuroendocrine differentiation that results from the transformation of castration-resistant prostate adenocarcinoma following potent androgen-deprivation therapy. The prognosis is poor.


name: Pathologic Stage I Cutaneous Melanoma AJCC v8

description: Stage I includes: IA: (T1a, N0, M0); (T1b, N0, M0); IB: (T2a, N0, M0). T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Acute rheumatic pericarditis

description: Inflammation of the pericardium in acute rheumatic heart disease.


name: Squamous Cell Carcinoma of Unknown Primary

description: A squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified.


Malignant Abdominal Neoplasm

description: A primary or metastatic malignant neoplasm that affects the organs and structures of the abdomen.


Localized Gallbladder Carcinoma

description: A carcinoma that arises from the gallbladder and it has not spread to other anatomic sites.


Bacterium-Related Malignant Neoplasm

description: A malignancy in which there is a well-documented association between a neoplastic process and a specific bacterium as the causative agent.


name: Stage I Pancreatic Cancer AJCC v6 and v7

description: Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0).  T1: Tumor limited to the pancreas 2 cm or less in greatest dimension.  T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Transitional cell cancer of the renal pelvis and ureter localized

description: Urothelial carcinoma of the renal pelvis or ureter that has not spread to adjacent tissues, regional lymph nodes, or distant anatomic sites.


name: Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

description: A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular or squamous differentiation and giant cells resembling osteoclasts.


Non-Neoplastic Ureter Disorder

description: A non-neoplastic disorder affecting the ureter.


Tumor contained within organ capsule

description: A neoplasm surrounded by a fibrous capsule.


name: Childhood Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for childhood Hodgkin lymphoma based on the Ann Arbor classification criteria.


name: histiocytic sarcoma of central nervous system

description: Rare involvement of the central nervous system by histiocytic sarcoma.


Pancreatic carcinoma non-resectable

description: Carcinoma of the pancreas that is not amenable to surgical removal.


name: Metastatic Malignant Neoplasm in the Lacrimal Drainage System

description: A malignant neoplasm that has spread from its original site of growth to the lacrimal drainage system.


Metachronous Malignant Neoplasm

description: A malignant tumor that arises at a site separate from another, primary malignant tumor in the same anatomic system.  It is not clear if metachronous malignant neoplasms represent new primary tumors or metastatic disease.  Examples include metachronous osteosarcoma of the bones that develops in patients with known primary bone osteosarcoma, and metachronous Wilms' tumor that affects the opposite kidney in patients with a history of Wilms' tumor.


Peritoneal Diseases

description: A non-neoplastic or neoplastic disorder that affects the peritoneum.  Representative examples of non-neoplastic disorders include peritonitis and panniculitis.  Representative examples of neoplastic disorders include adenomatoid tumor, primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma.


name: Childhood Benign Connective and Soft Tissue Neoplasm

description: A childhood neoplasm that arises from connective and soft tissue and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Locally Advanced Vulvar Carcinoma

description: Vulvar carcinoma that has spread to nearby tissues or lymph nodes.


Resectable Glioma

description: A glioma that is amenable to surgical resection.


Vulvar Germ Cell Tumor

description: A rare germ cell tumor that arises from the vulva.


High Grade Fever

description: Body temperature of 104 degrees Fahrenheit (40 degrees Celsius) or higher.


Neuroendocrine breast tumor

description: A well-differentiated neuroendocrine neoplasm that arises from the breast. It may be classified as G1 (low grade) or G2 (intermediate grade) neuroendocrine tumor.


Atypical Gastric Lymphoid Hyperplasia

description: An atypical lymphoid hyperplasia involving the gastric mucosa.


Childhood Low Grade Glioma

description: A low-grade glioma that occurs during childhood.


Unilateral Anophthalmos

description: A rare congenital abnormality characterized by the complete absence of ocular tissue in one orbit.


name: Stage IA Esophageal Adenocarcinoma AJCC v7

description: Stage IA includes: T1, N0, M0, G1-2, X. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  G2: Moderately differentiated. GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


name: Stage IV Appendix Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, N0, N1, M1); (T2, N0, N1, M1); (T3, N0, N1, M1); (T4, N0, N1, M1). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm but less than or equal to 4 cm. T3: Tumor measuring more than 4 cm or with subserosal invasion or involvement of the mesoappendix. T4: Tumor perforating the peritoneum or directly invading other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), e.g., abdominal wall and skeletal muscle. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Metastatic small cell carcinoma

description: A small cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site.


Granulosa cell-theca cell tumor

description: A general term used to describe sex cord-stromal tumors characterized by the presence of granulosa cells in a thecomatous/fibrothecomatous background.


name: Platinum-Resistant Fallopian Tube High Grade Serous Adenocarcinoma

description: Fallopian tube high-grade serous adenocarcinoma that progresses between one and six months of completing platinum therapy.


Dermal Melanoma

description: A melanoma that is confined to the dermis and subcutaneous tissue without involvement of the epidermis.


name: Gastroesophageal Junction Large Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gastroesophageal junction.  It is characterized by the presence of malignant large cells.


name: Pancreatic Poorly Differentiated Ductal Adenocarcinoma

description: A pancreatic ductal adenocarcinoma characterized by the presence of small and irregular malignant glandular structures, solid sheets of malignant cells, and single malignant cells.


name: T-Cell Large Granular Lymphocyte Leukemia, Common Variant

description: T-cell large granular lymphocyte leukemia defined by the presence of CD3-positive, CD8-positive, and T-cell receptor alpha-beta-positive cytotoxic T-cells.


Gastric Cancer by AJCC v7 Stage

description: A term that refers to the staging of gastric carcinoma according to the American Joint Committee on Cancer, 7th edition.


Radiculoneuropathy

description: Spontaneous degeneration of the spinal cord and peripheral nerves characterized by myelin sheath vacuolation, Wallerian degeneration and intramyelinic space infiltration by macrophages.


name: Unspecified deformity of forearm, excluding fingers

description: Any anatomic abnormality of the arm located between the elbow and the wrist.


Acute Myeloid Leukemia with del(7q)

description: Acute myeloid leukemia associated with deletion of the long arm of chromosome 7 [del(7q)].


name: Muscular Dystrophy Secondary to Mitochondrial Disorder

description: A muscular dystrophy that was caused by a primary mitochondrial disorder.


Locally Advanced Adenocarcinoma

description: Adenocarcinoma that has spread to nearby tissues or lymph nodes.


Gallbladder Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Intermediate Bone Neoplasm

description: A locally aggressive or rarely metastasizing neoplasm that arises from the bone.


name: Unresectable Peritoneal Malignant Mesothelioma

description: Peritoneal malignant mesothelioma that is not amenable to surgical resection.


Fuchs' adenoma

description: A benign proliferation of the pars plicata epithelium of the ciliary body. It is associated with aging..


Embolism, Amniotic Fluid

description: Acute hypotension or cardiac arrest, acute hypoxia or coagulopathy in the absence of any other potential explanation related to the presence of amniotic fluid or the fetal debris within the maternal vascular system during the antepartum or intrapartum period.


name: Hematologic Neoplasm with Germline Predisposition

description: A term that refers to myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, and acute myeloid leukemias that are associated with germline mutations and are familial.


Stage IIIA Vulvar Cancer AJCC v7

description: Stage IIIA includes: (T1/T2, N1a/N1b, M0); T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  N1a: Vulvar cancer with one or two lymph node metastasis each measuring 5 mm or less.  N1b: Vulvar cancer with one lymph node metastasis measuring 5 mm or greater.  M0: No distant metastasis.  (AJCC 7th ed.)


Malignant Testicular Sertoli Cell Tumor

description: A Sertoli cell tumor that arises from the testis and is characterized by nuclear pleomorphism, increased mitotic activity and necrotic changes.  Metastases may be present at diagnosis.


Recurrent Malignant Germ Cell Tumor

description: The reemergence of a malignant germ cell tumor after a period of remission.


Congenital Platelets Abnormality

description: A group of rare inherited platelet disorders that involve abnormalities of platelet function or platelet production and that usually cause moderate to severe bleeding problems.


name: Lugano Classification Childhood Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for childhood Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Adult Angiosarcoma

description: An angiosarcoma occurring in the adult population.


neoplasm of optic chiasm

description: A benign or malignant neoplasm that affects the optic chiasm.


Abscess of pituitary

description: An inflammatory or infectious process in the pituitary gland characterized by a circumscribed, walled collection of purulent material.


Metastatic Conjunctival Melanoma

description: Conjunctival melanoma that has spread from its original site of growth to another anatomic site.


name: Localized Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: An undifferentiated high grade pleomorphic sarcoma of bone that occurs in adulthood and has not spread to other anatomic sites.


Refractory Melanoma

description: Melanoma that does not respond to treatment.


name: Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage

description: A staging system for Hodgkin lymphomas based on the Lugano classification criteria. Staging for childhood Hodgkin lymphoma is the same as for the adult counterpart. (from AJCC 8th Ed.)


Central Nervous System Paraganglioma

description: An extra-adrenal paraganglioma arising from the central nervous system.


Nuclear Cataract Grade 4

description: A stage of nuclear sclerotic cataract marked by severe yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Tuberculous abscess

description: An abscess resulting from infection by Mycobacterium tuberculosis.


description: An epithelioid hemangioendothelioma that has spread from its original site of growth to another anatomic site.


Papillary carcinoma in situ

description: An epithelial neoplasm with a papillary growth pattern in which the malignant cells are confined to the epithelium, without evidence of invasion.


Unresectable Prostate Carcinoma

description: Prostate carcinoma that is not amenable to surgical resection.


Olfactory neurogenic tumor

description: A rare, benign (olfactory neurocytoma) or malignant (olfactory neuroblastoma) neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity.


name: Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma

description: Nodular sclerosis Hodgkin lymphoma in which at least 25% of the tumor nodules contain increased numbers of Reed-Sternberg cells.


name: Metastatic malignant neoplasm to lacrimal gland

description: A malignant neoplasm that has spread from its original site of growth to the lacrimal gland.


Malignant Fundus Neoplasm

description: A primary or metastatic malignant neoplasm that affects the gastric fundus.


name: Stage I Extragonadal Non-Seminomatous Germ Cell Tumor


name: Stage IIB Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIB includes: T2b, N0, M0.  T2b: Extension to other pelvic structures.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


name: Polyostotic Langerhans cell histiocytosis

description: Langerhans cell histiocytosis presenting with multiple sites of involvement.


name: Stage III Acral Lentiginous Melanoma AJCC v7

description: Stage III includes: Any T, N1-3, M0.  Stage III is divided into three pathologic subgroups: IIIA, IIIB, and IIIC.  There are no clinical subgroups for stage III.  N1: Cutaneous melanoma with metastasis in one regional lymph node.  N2: Cutaneous melanoma with metastases in 2-3 regional lymph nodes or in transit met(s)/satellite(s) without metastatic nodes.  N3: Cutaneous melanoma with 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s).  M0: No detectable evidence of distant metastases. (from AJCC 7th Ed.)


Diencephalic Glioblastoma

description: A glioblastoma that occurs in the diencephalon.


Nightmare Disorder

description: A sleep disorder characterized by the repeated occurrence of frightening dreams which precipitate awakenings from sleep; on awakening, the individual becomes fully alert and oriented and has detailed recall of the nightmare, which usually involves imminent danger or extreme embarrassment to the individual.


Retinoblastoma, spontaneously regressed

description: An archaic term that refers to benign, non-progressive retinal lesions in patients with mutation of the RB1 gene.


name: Atypical Melanocytic Nevus of Genital Type

description: A small, well circumscribed melanocytic neoplasm that arises from the vulva and affects women in their reproductive years. It is characterized by the presence of junctional nests of melanocytes. Some of the superficial melanocytes show atypia. During pregnancy the atypical melanocytic changes may appear more prominent. This neoplasm is not associated with the presence of dysplastic nevi in other anatomic areas.


Refractory Prostate Carcinoma

description: Prostate carcinoma that is resistant to treatment.


name: Recurrent Female Reproductive System Carcinoma

description: The reemergence of female reproductive system carcinoma after a period of remission.


name: Lugano Classification Stage III Childhood Hodgkin Lymphoma AJCC v8

description: Stage III: Involvement of lymph node regions on both sides of the diaphragm; nodes above the diaphragm with spleen involvement. (from AJCC 8th Ed.)


name: Stage III Childhood Retinoblastoma by Toronto Guidelines v2

description: Regional extension: involvement of the orbit and/or preauricular or cervical lymph node extension. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Tracheal fistula

description: An abnormal communication between the trachea and another organ or anatomic site.


Septic arthritis staphylococcal

description: Arthritis due to staphylococcal sepsis.


Eating disorder symptom

description: Abnormal eating behaviors, including binge eating, compulsive eating, emotional eating, night eating, and self-induced vomiting, though not at a level that rises to the diagnosis of eating disorder.


Transthyretin amyloid cardiomyopathy

description: Cardiomyopathy resulting from the deposition of misfolded transthyretin. The condition can be classified by the presence (hereditary transthyretin amyloid) or absence (wild-type transthyretin amyloid) of mutation(s) in the TTR gene, encoding transthyretin.


name: Adenocarcinoma of the prostate metastatic

description: An adenocarcinoma that arises from the prostate gland and has spread to other anatomic sites.


Bladder Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the bladder.


Stage IB Cervical Cancer AJCC v8

description: Stage IB includes: T1b, Any N, M0. T1b: Tumor with clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. It includes all macroscopically visible lesions, even those with superficial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Intermediate Grade Adult Non-Hodgkin's Lymphoma


Venous Stroke

description: Ischemic or hemorrhagic stroke resulting from cerebral venous thrombosis.


name: Fetus Small for Gestational Age with Oligohydraminos

description: A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age and shows evidence of oligohydramnios.


Cervical Cancer by FIGO Stage 2009

description: A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2009.


name: Non-Neoplastic Central Nervous System Disorder


Stenosis

description: Narrowing or stricture of a vessel, duct or canal.


Vascular disorder of intestine

description: A non-neoplastic or neoplastic vascular disorder that affects the intestines.


Cerebellar sarcoma

description: An obsolete term referring to desmoplastic medulloblastoma.


Gastric Non-Neoplastic Polyp

description: A non-neoplastic polyp that arises from the stomach.  This category includes hyperplastic polyps and hamartomatous polyps.


Squamous Papilloma of the Urinary Tract

description: A rare papillary neoplastic growth that arises from the urothelial mucosa. It is characterized by the presence of fibrovascular cores lined by benign keratinizing squamous epithelium. There is no evidence of architectural or cytologic atypia. It usually occurs in elderly people and is found in the bladder and urethra.


Stage IIIA Esophageal Cancer AJCC v7

description: Stage IIIA includes: For squamous cell carcinoma: (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G). T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IB2 Cervical Cancer AJCC v8

description: Stage IB2 includes: T1b2, Any N, M0. T1b2: Tumor with clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Radiation anemia

description: Anemia arising due to radiation therapy.


name: Melanoma in Intermittently Sun-Exposed Skin

description: A melanoma that arises from the skin in the absence of severe actinic keratosis. It can arise from a pre-existing nevus or de novo.


Invasive listeriosis

description: A bacterial infection by Listeria monocytogenes in a sterile body compartment.


Stage 0 Pancreatic Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. This includes high-grade pancreatic intraepithelial neoplasia (PanIn-3), intraductal papillary mucinous neoplasm with high-grade dysplasia, intraductal tubulopapillary neoplasm with high-grade dysplasia, and mucinous cystic neoplasm with high-grade dysplasia.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Defects in Intrinsic and Innate Immunity

description: A group of diseases or disorders caused by genetic defects within the immune system, comprised by: Mendelian susceptibility to mycobacterial disease (MSMD); Epidermodysplasia verruciformis (HPV); Predisposition to severe viral infection; Herpes simplex encephalitis (HSE); Predisposition to invasive fungal diseases; Predisposition to mucocutaneous candidiasis; TLR signaling pathway deficiencies with bacterial susceptibility; and other inborn errors of immunity related to nonhematopoietic tissues.


name: Lymphocyte-Depleted Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for lymphocyte-depleted classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Metastatic Unresectable Sarcoma

description: A metastatic sarcoma that is not amenable to surgical resection.


name: Locally Advanced Esophageal Adenocarcinoma

description: Esophageal adenocarcinoma that has spread to nearby tissues or lymph nodes.


name: Stage IIA Digestive System Neuroendocrine Tumor AJCC v7

description: Stage IIA includes: T2, N0, M0.  T2: Stomach/ duodenum /jejunum/ileum: tumor invades muscularis propria or is more than 1 cm in size; ampulla: tumor is more than 1 cm in size; colon or rectum: tumor invades muscularis propria or is more than 2 cm in size with invasion of lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis

description: A myelodysplastic/myeloproliferative neoplasm characterized by marked thrombocytosis, anemia, erythroid lineage dysplasia, presence or absence of multilineage dysplasia, 15% or more ring sideroblasts, blasts less than 5% in bone marrow and less than 1% in peripheral blood, absence of BCR/ABL fusion, absence of SF3B1 mutation, absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions, and no history of other myelodysplastic/myeloproliferative neoplasms or myeloproliferative neoplasms and myelodysplastic syndromes.


Metastatic Appendix Adenocarcinoma

description: Appendix adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Hodgkin's disease nodular sclerosis stage I

description: Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).


name: Ann Arbor Stage III AIDS-Related Lymphoma

description: Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).


Pancreatic Neuroendocrine Microtumor

description: A non-functioning pancreatic neuroendocrine tumor measuring less than 0.5 cm in diameter.


Refractory Neoplasm

description: A neoplasm that does not respond to treatment.


Posterior Subcapsular Cataract Grade 3

description: A stage of posterior subcapsular cataract characterized by 50% of the posterior capsule obscured by opacity. (Modified LOCS II)


Prostate cancer stage B

description: Tumor is clinically palpable but confined to the prostate.


Metastatic Anal Canal Carcinoma

description: An anal canal carcinoma which has spread to another anatomic site.


name: Malignant Peritoneal and Retroperitoneal Neoplasm

description: A primary or metastatic malignant neoplasm that affects the peritoneum and/or retroperitoneum.


Stage IIA Cervical Cancer AJCC v6

description: Tumor without parametrial invasion.


Stage IVB Fallopian Tube Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1b. M1b: Fallopian tube cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine. (from AJCC 8th Ed.)


name: Stage IIIB Gestational Trophoblastic Tumor AJCC v7

description: Stage IIIB includes: Any T, M1a, Risk factors: high risk.  M1a: Lung metastasis.  (AJCC 7th ed.)


Recurrent Myxoid Glioneuronal Tumor

description: The reemergence of myxoid glioneuronal tumor after a period of remission.


name: Chronic total occlusion of coronary artery

description: Prolonged complete obstruction of the coronary artery. (ACC)


Fibrinolysis Shutdown

description: Acute impairment of breaking down fibrin clots leading to venous thromboembolism, stroke, and renal failure.


Metastatic Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to another anatomic site.


Lymphoma by AJCC v8 Stage

description: A term that refers to the staging of Hodgkin lymphoma and non-Hodgkin lymphoma according to the AJCC v8 classification guidelines.


Incarcerated inguinal hernia

description: The trapping of bowel or omentum inside the inguinal canal that cannot be reduced, resulting in inflammation, pain, nausea, and possible bowel obstruction.


Glycogen storage disease, type IX

description: Glycogen storage disease usually inherited in an X-linked recessive pattern.  It is characterized by a deficiency of hepatic phosphorylase kinase.


Pinhole meatus

description: A narrowing of the opening of the urethra at the external meatus.


Hemoglobin Level Finding

description: A finding that indicates the amount of hemoglobin in a sample.


AIDS-Related Carcinoma

description: Carcinoma occurring in HIV-positive patients.


Paratesticular Carcinoma

description: A carcinoma that arises from the paratesticular structures.


Granuloma annulare aggravated

description: A chronic, inflammatory skin condition characterized by raised, ring shaped eruptions occurring singly or in groups; often on the tops of the hands, feet, elbows, and knees. It is commonly seen in children and young adults, and in women twice as much as men.


Bladder Cancer by AJCC v6 Stage

description: A term that refers to the staging of bladder cancer according to the American Joint Committee on Cancer, 6th edition.


Stage I Ampulla of Vater Cancer AJCC v7

description: Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0). T1: Tumor limited to ampulla of Vater or sphincter of Oddi.  T2: Tumor invades duodenal wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Metastatic Malignant Neoplasm to the Cervix

description: A malignant neoplasm that has spread to the cervix from another anatomic site.


Anal Canal Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process involving the anal canal.  When it is clinically noticeable, it may appear as an eczematous or papillary lesion, plaques, or papules.  Morphologically, it is characterized by loss of epithelial stratification and nuclear polarity, cytologic atypia, and the presence of mitotic figures.  It may be classified as low or high grade.


name: immune effector cell-associated neurotoxicity syndrome, grade 2

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 3, 4, 5, or 6 (for adults and children over 12), or a Cornell Assessment of Pediatric Delirium (CAPD) score of less than 9 (for children 12 and under), and the ability of the affected individual to awaken to voice commands.


Laryngeal nerve palsy

description: Damage to the laryngeal nerve that results in paralysis of the layrnx.


Acinar cell tumor

description: A benign or malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. It includes the acinar cell adenoma and acinar cell carcinoma.


Primary Ciliary Dyskinesia 42

description: An autosomal recessive primary ciliary motility defect caused by mutation(s) in the MCIDAS gene, encoding multicilin.


name: Helicobacter Pylori-Related Malignant Neoplasm


description: A pleomorphic xanthoastrocytoma that arises from the supratentorial region of the brain.


Spinal nerves paralysis permanent

description: Spinal nerve paralysis that is irreversible.


name: Low grade cervical glandular intraepithelial neoplasia

description: Cervical glandular intraepithelial neoplasia characterized by the presence of mild dysplastic changes.


Malignant Pancreatic Vipoma

description: A pancreatic neuroendocrine tumor producing vasoactive intestinal peptide (VIP).  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria.  It displays vascular invasion and metastasizes to other anatomic sites.  One third of cases are metastatic at the time of diagnosis.


Locally Recurrent Gastric Carcinoma

description: The reemergence of gastric carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Recurrent Primary Central Nervous System Neoplasm

description: The reemergence of a primary central nervous system neoplasm after a period of remission.


Angiosarcoma Associated with Lymphedema

description: An angiosarcoma that develops in association with long standing lymphedema.


T/NK-Cell Lymphoproliferative Disorder

description: A non-neoplastic or neoplastic proliferation of T-lymphocytes and/or NK-cells.


name: Central Nervous System Langerhans Cell Histiocytosis

description: Rare involvement of the central nervous system by Langerhans cell histiocytosis.


Acute Heart Failure Related to COVID-19

description: New or worsening signs of heart failure in a patient with probable or confirmed acute COVID-19. This can be the first presentation or it can reflect an acute decompensation in a patient with history of chronic heart failure.


name: Mucinous cystic neoplasm with low-grade intraepithelial neoplasia of gallbladder

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of mild atypia.


Stage IIIA Testicular Cancer AJCC v8

description: Stage IIIA includes: (Any pT/TX, Any N, M1a, S0); (Any pT/TX, Any N, M1a, S1). TX: Testicular cancer in which the primary tumor cannot be assessed. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N and hCG (mlU/mL) less than 5,000 and AFP (ng/mL) less than 1,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Sacral Fistula

description: A pathologic communication between the skin and the dural space that is located 5-25 mm from the anal verge.


name: Extrahepatic Bile Duct Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: Locally Advanced Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain that has spread from its original site of growth to nearby tissues or lymph nodes.


Retinoblastoma, differentiated

description: A retinoblastoma with well differentiated features. It often produces Flexner-Wintersteiner rosettes or Homer-Wright rosettes. In some cases the tumor cells form fleurettes.


Metastatic Gastric Carcinoma

description: A gastric carcinoma that has spread from its original site of growth to another anatomic site.


Mesothelioma malignant localised

description: A malignant mesothelioma with the gross appearance of a circumscribed serosal lesion and the microscopic appearance of diffuse malignant mesothelioma, without evidence of diffuse spread.


name: Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

description: The reemergence of a blastic plasmacytoid dendritic cell neoplasm after a period of remission.


Dactylomegaly

description: A condition in which the fingers or toes are abnormally enlarged.


Non-Communicable Disorder

description: A disorder that is not transmissible from one person to another.


Salmonella sepsis

description: Sepsis due to the presence of Salmonella bacteria in the bloodstream.


Meningococcal endocarditis

description: Endocarditis caused by bacterial infection with Meningococcus species.


Childhood Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that occurs during childhood.


Cervical Germ Cell Tumor

description: A rare germ cell tumor that arises from the cervix. Examples include mature cystic teratoma, yolk sac tumor, and choriocarcinoma.


Hereditary factor I deficiency disease

description: An inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding.


Childhood Malignant Endocrine Neoplasm

description: A malignant neoplasm arising from the epithelial cells of an endocrine organ during childhood.


Stage IIC Appendix Carcinoma AJCC v8

description: Stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Stage 0 Pancreatic Cancer AJCC v6 and v7

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th Eds.)


name: Cutaneous Histiocytic and Dendritic Cell Neoplasm

description: A histiocytic and dendritic cell neoplasm that affects the skin.


name: Childhood Astrocytoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood astrocytoma according to the Toronto childhood cancer staging guidelines v2. This staging system is the same for both tiers (tier 1 and 2). (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)