name: Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential

description: A premalignant neurofibromatous neoplasm characterized by the presence of at least two of the following features: cytologic atypia, hypercellularity, less than 3 mitotic figures per 10 HPFs, and loss of neurofibroma architecture. It is associated with an increased risk of progression to malignant peripheral nerve sheath tumor.


Leukemia, Radiation-Induced

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Leukemia that is caused by radiation.


Congenital anomaly of lens

description: Any anatomic abnormality or physiologic dysfunction of the lens of the eye that is present at the time of birth.


Stage IIIB Esophageal Cancer AJCC v7

description: Stage IIIB includes: For squamous cell carcinoma: T3, N2, M0, Any G, Tumor location: Any. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Brief depressive adjustment reaction

description: Temporary maladaptive depressive signs and symptoms associated with a life event.


Epithelioid glioblastoma

description: An IDH-wildtype glioblastoma characterized by the presence of large epithelioid cells with abundant eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli.


Non-Infectious Cystitis

description: An inflammation of the bladder which is not caused by an infection of the urinary tract. Representative examples include interstitial cystitis and radiation-induced cystitis.


Arsenical keratosis

description: A hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic.


name: Stage I Gestational Trophoblastic Neoplasm AJCC v8

description: Stage I includes: T1, M0. T1: Gestational trophoblastic neoplasm in which the tumor is confined to uterus. M0: No distant metastasis. (AJCC 8th Ed.)


Surfactant Protein C Deficiency

description: Deficiency of surfactant protein C. It leads to progressive lung fibrosis.


Hemorrhagic gastritis

description: Inflammation of the stomach resulting in bleeding.


Unresectable Neuroendocrine Carcinoma

description: Neuroendocrine carcinoma that is not amenable to surgical resection.


Uterine Ligament Ependymoma

description: A rare neoplasm that arises from the broad or other uterine ligaments and shows ependymal differentiation.


name: Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor

description: A usually indolent neuroendocrine neoplasm that almost exclusively arises in the second part of the duodenum. Rare sites of involvement include jejunum, pylorus, appendix, thymus, and lung. It is a triphasic tumor consisting of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.


name: Stage 0 Esophageal Adenocarcinoma AJCC v7

description: Stage 0 includes: Tis (HGD), N0, M0, G1,GX.  Tis: High-grade dysplasia.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1. (AJCC 7th ed.)


Squamous Hyperplasia

description: A hyperplasia of the squamous epithelial cells.


name: Malignant Neoplasm of Lung - Multiple Primary Sites

description: Lung cancer comprising malignant neoplasms from two or more sites, as determined by clinicoopathological assessment.


Epigastric hernia

description: Protrusion of abdominal cavity contents or pre-peritoneal fat through the abdominal wall between the umbilicus and the xiphoid process.


Lacrimal Gland Warthin Tumor

description: A rare benign tumor that arises from the lacrimal gland. It is characterized by an oncocytic epithelial component and dense lymphoid stroma.


Benign Dermal Neoplasm

description: A neoplasm that arises from the dermis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Localized Prostate Adenocarcinoma

description: An adenocarcinoma that arises from the prostate and has not spread to other anatomic sites.


Congenital musculoskeletal anomalies

description: An abnormality of the musculoskeletal system that is present at birth or detected in the neonatal period.


Cutaneous Melanoma by AJCC v7 Stage

description: A term that refers to the staging of cutaneous melanoma, following the rules of the TNM AJCC v7 classification system.


Advanced Favorable Hodgkin Lymphoma

description: An advanced Hodgkin lymphoma with favorable prognosis.


Non-Neoplastic Pleural Disorder

description: A non-neoplastic disorder that affects the pleura.  Representative examples include pleural infection and pneumothorax.


Childhood Compound Nevus

description: A compound nevus that occurs during childhood.


Trigeminal nerve palsy

description: Partial or complete paralysis of the trigeminal nerve.


Abnormal Cardiac Study

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A history of having had an abnormal cardiac study.


Overt Stroke

description: A cerebral infarction that is evident by new neurological symptoms lasting greater than 24 hours or having an area of diffusion restriction or a T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensity on an MRI of the brain that was consistent with the neurological findings.


name: Placental Site Nodule and Plaque Occurring in the Fallopian Tube

description: A rare non-neoplastic trophoblastic disorder characterized by the presence of remnants of intermediate trophoblasts in the fallopian tube from a previous pregnancy.


Locally Advanced Pancreatic Carcinoma

description: A pancreatic carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Childhood Acute Erythroid Leukemia

description: An acute erythroid leukemia occurring in children.


name: Verrucous carcinoma of the oral cavity stage I


name: Genetic Syndrome Associated with Congenital Heart Defect

description: Genetic anomalies and collections of malformations that are known to cluster together that can be associated with congenital heart defects. (ACC/AHA)


name: Refractory Endometrial Serous Adenocarcinoma

description: Endometrial serous adenocarcinoma that is resistant to treatment.


name: Lacrimal Drainage System Adenoid Cystic Carcinoma

description: A carcinoma that arises from the lacrimal sac. It is characterized by the presence of malignant epithelial cells that form cribriform, tubular, and solid patterns.


name: Recurrent Endometrial Dedifferentiated Carcinoma

description: The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


Adult Benign Brain Neoplasm

description: A benign neoplasm of the brain occurring in adults.


name: Metastatic Prostate Adenocarcinoma with Neuroendocrine Differentiation

description: Prostate adenocarcinoma with neuroendocrine differentiation that has spread from its original site of growth to another anatomic site.


name: Clear Cell Tumor with Melanocytic Differentiation and ACTIN-MITF Translocation

description: A MITF pathway-activated melanocytic tumor characterized by a cytogenetic translocation between ACTIN and MITF genes that results in ACTIN-MITF gene fusion. It presents as a single non-pigmented cutaneous nodule in the distal extremities or trunk. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis without an intraepidermal component. Extension in the subcutaneous tissue is frequently seen. Atypical nuclear features may be present. It has an indolent clinical course.


name: Metastatic Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that has spread from its original site of growth to another anatomic site.


name: Adnexal Adenocarcinoma, Not Otherwise Specified

description: An adnexal carcinoma with ductal/glandular differentiation lacking specific histological features that would allow further classification. (WHO 2018)


description: A hematologic malignancy that arises in a patient with a history of organ transplantation.


Childhood Benign Skin Neoplasm

description: A childhood neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Recurrent Endometrial Cancer

description: The reemergence of endometrial carcinoma after a period of remission.


name: Complex endometrial hyperplasia without atypia

description: A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures. Epithelial atypia is absent.


Chest Wall Disorder

description: A non-neoplastic or neoplastic disorder that affects the structures of the chest wall.  Representative examples include infection, chest wall lipoma, and chest wall lymphoma.


Metastatic adenoid cystic carcinoma

description: An adenoid cystic carcinoma that has spread from the original site of growth to other anatomic sites.


Epstein-Barr virus infection recurrent

description: An Epstein-Barr virus infection that has recurred after a period of remission.


Cervical myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the cervical region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


name: Metastatic Malignant Neoplasm in the Lacrimal System

description: A malignant neoplasm that has spread from its original site of growth to the lacrimal gland or lacrimal drainage system.


Nutritional Hypophosphatemic Rickets

description: Hypophosphatemic rickets due to insufficient dietary phosphate intake or absorption.


Adult Intracranial Germ Cell Tumor

description: A germ cell tumor that arises within the cranium and occurs during adulthood.


name: Stage I Childhood Retinoblastoma by Toronto Guidelines v2

description: Enucleation with negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Phlebitis of portal vein

description: Inflammation of the portal vein.


Basal-Like Prostate Carcinoma

description: Prostate carcinoma in which the CD49f signature is increased, the luminal markers and androgen receptor expression and signaling (androgen activity pathway) are not increased, and the proliferation score is higher than the luminal A prostate carcinoma.


Stage II Gallbladder Cancer AJCC v7

description: Stage II includes: T2, N0, M0.  T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Gestational diabetes mellitus class A2

description: Carbohydrate intolerance first diagnosed during pregnancy. Diagnosis from abnormal oral glucose tolerance test (OGTT) and abnormal fasting or post-prandial glucose levels. Euglycemia achieved with medication.


name: Stage II Intermediate Grade Adult Non-Hodgkin's Lymphoma


name: Stage IIIA Uterine Corpus Cancer AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus carcinoma or carcinosarcoma with tumor involving the serosa and/or adnexa (direct extension or metastasis). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Unresectable Digestive System Carcinoma

description: Digestive system carcinoma that is not amenable to surgical resection.


Recurrent basal cell carcinoma

description: The reemergence of basal cell carcinoma after a period of remission.


Refractory Childhood Malignant Neoplasm

description: A childhood malignant neoplasm that does not respond to treatment.


NADH Dehydrogenase Deficiency

description: A rare metabolic disorder characterized by the deficiency of mitochondrial NADH dehydrogenase component of complex I. Signs and symptoms include cardiomyopathy, encephalopathy, enlarged head, and progressive leukodystrophy.


name: Cutaneous Melanoma by AJCC v8 Pathologic Stage

description: A term that refers to the pathologic staging of cutaneous melanoma, following the rules of the TNM AJCC v8 classification system.


Current EBV Infection

description: Epstein-Barr virus infection is evident at the time of testing.


Infection pyogenic

description: An infection caused by pus-producing organisms.


name: Childhood Ependymoma by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood ependymoma according to the tier 1 Toronto childhood cancer staging guidelines v2.


Pulmonary Embolism Related to COVID-19

description: Pulmonary embolism in a patient with probable or confirmed acute COVID-19.


Third degree uterine prolapse

description: The uterus has descended below the level of the hymen and protrudes through the opening of the vagina.


Non-Neoplastic Chest Wall Disorder

description: A non-neoplastic disorder that affects the structures of the chest wall.


name: Stage III Pancreatic Cancer AJCC v6 and v7

description: Stage III includes: T4, Any N, M0. T4: Tumor involves the celiac axis or the superior mesenteric artery.  M0: No distant metastasis.  (AJCC 6th and 7th Eds.)


name: Recurrent Acute Myeloid Leukemia with Multilineage Dysplasia

description: The reemergence of acute myeloid leukemia with multilineage dysplasia after a period of remission.


Stage IVB Appendix Carcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1b, G2, G3, or GX. M1b: Intraperitoneal metastasis only, including peritoneal mucinous deposits containing tumor cells. G2: Moderately differentiated. G3: Poorly differentiated. GX: Grade cannot be assessed.  (AJCC 8th ed.)


name: Metastatic Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread to another anatomic site.


name: Non-Neoplastic Trigeminal Nerve Disorder

description: A non-neoplastic disorder affecting the trigeminal nerve.


name: Stage II Childhood Malignant Kidney Neoplasm Excluding Renal Cell Carcinoma by Toronto Guidelines v2, Children's Oncology Group (COG) Protocol

description: Tumor extends beyond kidney but completely resected. Tumor penetrates renal capsule. Tumor in lymphatics or veins of renal sinus. Tumor in renal vein with margin not involved. No nodal or hematogenous metastases. Negative margins. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Unresectable Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that is not amenable to surgical resection.


Pelvic Floor Disorders

description: A disorder affecting the muscles of the pelvic floor.


name: FIGO Stage IV Gestational Trophoblastic Tumor

description: Gestational trophoblastic tumor in all other metastatic sites.


Focal KATP-Associated Hyperinsulinism

description: KATP-associated hyperinsulinism in which there is an area of adenomatous beta-cell hyperplasia. This condition results from paternal recessive mutation(s) in either the ABCC8 or the KCNJ11 gene and paternal uniparental isodisomy of chromosome region 11p15 with loss of tumor suppressor genes expressed from the maternally inherited chromosome.


Locally Advanced High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Benign Childhood Central Nervous System Neoplasm

description: A childhood neoplasm that arises from the central nervous system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Enteric campylobacteriosis

description: A gastrointestinal infection attributed to the bacteria campylobacter. It is usually contracted by consuming raw or undercooked poultry or consuming a food that has been in contact with raw poultry. It is characterized by abdominal pain, fever, and  diarrhea and usually resolves in two to five days.


name: FIGO Stage IIIB Gestational Trophoblastic Tumor


Rhinovirus infection

description: An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well.


Stage IVB Vulvar Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, M1.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 6th and 7th eds.)


Hemophilus influenza infection

description: An infection that is caused by the organism Hemophilus influenza.


name: Recurrent Adult Diffuse Mixed Cell Lymphoma

description: The reemergence of adult diffuse mixed cell lymphoma after a period of remission.


Refractory Carcinoma

description: A carcinoma that does not respond to treatment.


Multifocal Glioblastomas

description: The occurrence of multiple and independent glioblastomas that are unrelated to inherited neoplastic syndromes.


name: Metastatic Digestive System Neuroendocrine Tumor G3

description: Digestive system neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


Gastroenteritis enteroviral

description: Gastroenteritis resulting from an infection with enterovirus.


Accelerated Phase Primary Myelofibrosis

description: Rapid progression of primary myelofibrosis, characterized by the presence of myeloblasts accounting for 10-19% of the peripheral blood white cells or the nucleated cells in the bone marrow.


name: Resectable Platinum-Resistant Malignant Germ Cell Tumor

description: A platinum-resistant malignant germ cell tumor that is amenable to surgical resection.


name: Childhood Favorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with favorable prognosis that occurs during childhood.


Advanced Gallbladder Carcinoma

description: Gallbladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Prostate Carcinoma by Gene Expression Profile

description: A header term that includes the following prostate carcinoma subtypes determined by gene expression profiling: luminal A prostate carcinoma, luminal B prostate carcinoma, and basal-like prostate carcinoma.


Prostatic Basal Cell Hyperplasia

description: A type of prostatic hyperplasia.  It is characterized by the presence of nodules of dark basal cells around residual prostatic secretory cells.


name: Recurrent Acute Myeloid Leukemia Not Otherwise Specified

description: The reemergence of acute myeloid leukemia not otherwise specified after a period of remission.


Benign neoplasm of cranial nerves

description: A neoplasm that arises from a cranial nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Refractory Acute Leukemia of Ambiguous Lineage

description: Acute leukemia of ambiguous lineage that is resistant to treatment.


Childhood Giant Cell Glioblastoma

description: A giant cell glioblastoma that occurs during childhood.


Syphilitic endocarditis

description: Endocarditis secondary to syphilis.


Non-Neoplastic Retinal Disorder

description: A non-neoplastic disorder that affects the retina.


description: The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission.


name: Childhood Acute Myeloid Leukemia Not Otherwise Specified

description: Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related.  This category includes entities classified according to the French-American-British classification scheme.


Cervical Blue Nevus

description: A nevus that arises from the cervix. It is characterized by the presence of benign, heavily pigmented dendritic melanocytes.


description: Gastritis that is characterized by erosion of the mucosal surface.


Congenital Disruption

description: A morphologic defect of an organ, part of an organ, or a larger region of the body that results from the extrinsic breakdown of, or an interference with, an originally normal developmental process.


Transient Organic Mental Disorder

description: An organic mental disorder that is temporary in nature.


Atrial Septum Lipomatous Hypertrophy

description: A condition in which deposits of fat accumulate within the interatrial septum.


name: EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

description: A clonal lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection.


name: Shared Neoantigen-Positive Malignant Solid Neoplasm

description: A malignant solid neoplasm that expresses unique tumor-specific neoantigens across a subset of patients.


Radiation-Related Sarcoma

description: A sarcoma that arises in the bones or soft tissues following exposure to ionizing or non-ionizing radiation.


name: Recurrent Chronic Myelomonocytic Leukemia

description: The reemergence of chronic myelomonocytic leukemia after a period of remission.


Appendix Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the appendix. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


Stage IA1 Cervical Cancer AJCC v9

description: Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Acute Myeloid Leukemia with t(3;12)(q26.2;p13.2); ETV6-MECOM

description: An acute myeloid leukemia associated with t(3;12)(q26.2;p13.2) resulting in the expression of ETV6-MECOM fusion gene.


name: Advanced Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Connective and Soft Tissue Disorder

description: A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


name: Metastatic Proximal Gastric Adenocarcinoma

description: A proximal gastric adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Basal Cell Carcinoma with Adnexal Differentiation

description: A basal cell carcinoma of the skin that is characterized by adnexal differentiation.


name: Central Nervous System Histiocytic and Dendritic Cell Neoplasm

description: A neoplasm that originates from histiocytes and accessory cells and affects the central nervous system.  It is usually associated with the presence of identical tumors outside the central nervous system.  Representative examples include Langerhans cell histiocytosis, histiocytic sarcoma, and follicular dendritic cell sarcoma.


name: Metastatic Bladder Nested Urothelial Carcinoma

description: Bladder nested urothelial carcinoma that has spread to another anatomic site.


name: Perianal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process involving the squamous epithelium of the perianal skin. Clinically, it usually presents as a white or red area in the perianal skin. Morphologically, it is characterized by full thickness dysplasia of the squamous epithelium and sometimes of the pilosebaceous epithelium. Human papillomavirus DNA sometimes may be identified in the dysplastic epithelium. It may recur after treatment, however only a small percentage of cases progress to squamous cell carcinoma.


Infectious Mediastinitis

description: An acute or chronic infectious process affecting the mediastinum.


Placenta, Retained

description: After delivery of neonate, placental retention that requires clinical intervention such as manual extraction, curettage or uterotonic medications.


name: Merkel Cell Polyoma Virus-Positive Merkel Cell Carcinoma

description: A Merkel cell carcinoma that is associated with Merkel cell polyoma virus infection.


Infratentorial Glioblastoma

description: A glioblastoma that occurs in the infratentorial region.


name: Malignant Lymphoma Follicular, Large Cleaved Cell Type


name: Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

description: A trichoblastoma characterized by the presence of neoplastic epithelial cell forming nodules. There are palisaded basaloid cells present at the periphery and pale larger cells with vesicular nuclei, prominent nucleoli, and abundant cytoplasm present at the center of the nodules. The epithelial cells are admixed with numerous small lymphocytes and occasional large multinucleated cells that resemble Reed-Sternberg cells.


name: Congenital Abnormalities of Erythrocyte Differentiation or Function

description: Inherited disorders involving abnormalities of red blood cell function, structure, or production. Some diseases in this group may be associated with bone marrow failure, neutropenia, and/or thrombocytopenia.


name: Metastatic malignant neoplasm to bone marrow

description: The spread of a malignant neoplasm from its original site of growth to the bone marrow.


name: Utricle-Associated Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the area of the utricle.


Acquired Cytomegaloviral Infection

description: An infection with the Cytomegalovirus that is not present from birth.


Biliary System Disorder

description: A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Adrenal Gland Hyperplasia II

description: Decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD3B2 gene. The lack of activity of this enzyme produces a type of congenital adrenal hyperplasia.


Refractory Gastric Adenocarcinoma

description: Gastric adenocarcinoma that is resistant to treatment.


Stage IV Vaginal Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4).  M0: No distant metastasis.  M1: Distant metastasis.  (AJCC 6th and 7th eds.)


Early Stage Cervical Carcinoma

description: A stage term that refers to cervical carcinoma stages IA, IB, and IIA.


name: Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that is not amenable to surgical resection.


Terminal Hematuria

description: Gross hematuria that occurs at the end of, or immediately after voiding.


name: Unresectable Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is not amenable to surgical resection.


name: Prostatic Clear Cell Cribriform Hyperplasia

description: A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


Metastatic Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to another anatomic site.


Stage IA Fallopian Tube Cancer AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Fallopian tube cancer with tumor limited to fallopian tube surface; no malignant cells in ascites or peritoneal washings N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Digestive System Small Cell Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system.  It is characterized by the presence of malignant small cells.


Early Localized Lyme Disease

description: An early stage of Lyme disease that may present within 3-30 days after a tick bite with a red, concentrically-expanding rash (erythema migrans), fatigue, chills, fever, headache, muscle and joint aches, and swollen lymph nodes.


Deficiency of vitamin D3

description: Abnormally low concentration of vitamin D3 (cholecalciferol) in the blood.


Abdominal Abscess

description: An abscess within the abdomen.


Arteriovenous fistula thrombosis

description: Partial or complete occlusion of the lumen within an arteriovenous fistula by a thrombus.


Stage IIIA Anal Cancer AJCC v8

description: Stage IIIA includes: (T1, N1, M0); (T2, N1, M0). T1: Tumor 2 cm or smaller. T2: Tumor larger than 2 cm but equal to or smaller than 5 cm. N1: Metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Locally Advanced Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Benign Hair Follicle Neoplasm

description: A neoplasm that arises from the hair follicle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Childhood Breast Neoplasm

description: A neoplasm that affects the breast and occurs during childhood.


Nutritional Calcium Deficient Rickets

description: Nutritional rickets due to dietary deficiency of calcium.


name: Hypogonadotropic Hypogonadism with Adrenal Hypoplasia Congenita

description: Hypogonadotropic hypogonadism with congenital adrenal hypoplasia associated with mutation(s) in the NR0B1 gene (on the X chromosome).


Adult Atypical Meningioma

description: An atypical meningioma that occurs during adulthood.


Neurological ventriculitis

description: Inflammation of a cerebral ventricle.


IgM Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgM monoclonal immunoglobulin in the blood or urine.


name: Stage IIIB Esophageal Adenocarcinoma AJCC v7

description: Stage IIIB includes: T3, N2, M0, Any G. T3: Tumor invades adventitia. N2: Metastasis in 3-6 regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


Obstructed Megaureter

description: A megaureter in which there is obstruction to the flow of urine at the ureterovesical junction.


Hindgut Neuroendocrine Tumor G2

description: A neuroendocrine tumor grade 2 that arises from the sigmoid colon, descending colon, or rectum.


name: Locally Advanced Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage II Centroblastic Follicular Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Extrahepatic bile duct cancer stage II

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the liver, gallbladder, pancreas, and/or unilateral branches or the portal vein (right or left) or hepatic artery (right or left).  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Breast hyperplasia

description: A general term that refers to hyperplastic proliferations of the epithelial cells in the breast parenchyma.  Examples include atypical ductal hyperplasia, usual ductal hyperplasia, columnar cell hyperplasia, and atypical lobular hyperplasia.


Testicular Cystic Trophoblastic Tumor

description: A rare trophoblastic neoplasm that arises in metastatic sites of testicular mixed germ cell tumors following chemotherapy, or is part of treated or untreated testicular mixed germ cell tumors, or is secondary to either chemotherapy-induced or spontaneous regression of testicular choriocarcinoma. It is characterized by the presence of cysts lined by squamoid trophoblastic cells. The cysts are often compressed surrounded by other germ cell components.


Genitourinary Signs and Symptoms

description: Patient complaints (symptoms), physical or laboratory findings (signs) related to the genitourinary system.


Nickel Metabolic Disorder

description: A storage disorder that results from impaired metabolism of nickel.


name: Recurrent Polymorphous Low Grade Neuroepithelial Tumor of the Young

description: The reemergence of polymorphous low-grade neuroepithelial tumor of the young after a period of remission.


Malignant neoplasm of bladder recurrent

description: The reemergence of a malignant bladder neoplasm after a period of remission.


Gastrointestinal carcinoma in situ

description: An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion.


Urostomy Prolapse

description: Displacement of the urostomy.


Lumbar Meningocele

description: A congenital abnormality in the lumbar region of the spine in which the meninges protrude through a defect in the spinal column.


name: Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread to another anatomic site.


name: Clinical Stage 0 Cutaneous Melanoma AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. Thickness: Not applicable. Ulceration status: Not applicable. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Oropharyngeal candidiasis

description: Infection of the oropharynx with, or disease caused by, Candida, especially C. albicans. This disease usually results from debilitation (as in immunosuppression and especially AIDS), physiologic change, prolonged administration of antibiotics, and iatrogenic and barrier breakage. SYN candidosis, moniliasis.


name: Unresectable Genitourinary System Carcinoma

description: Genitourinary system carcinoma that is not amenable to surgical resection.


Primary Cutaneous Mucinous Carcinoma

description: A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology).


name: Unresectable Vulvar Squamous Cell Carcinoma

description: Vulvar squamous cell carcinoma that is not amenable to surgical resection.


Lupus encephalitis

description: Encephalitis that is associated with systemic lupus erythematosus.


Childhood depression

description: Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide.


Adult Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during adulthood.


Stage IIB Esophageal Carcinoma

description: Stage IIB includes: For squamous cell carcinoma: (T2-3, N0, M0, G2-3, Tumor location: Upper, middle); (T1-2, N1, M0, Any G, Tumor location: Any).  For adenocarcinoma: (T3, N0, M0, Any G); (T1-2, N1, M0, Any G).  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  M0: No distant metastasis.  G1: Well differentiated.  GX: Grade cannot be assessed-stage grouping as G1.  G2: Moderately differentiated.  G3: Poorly differentiated.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Congenital spondylolysis

description: Spondylolysis, the cause of which is present from birth.


name: Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified

description: Acute leukemia of ambiguous lineage, expressing combinations of markers that do not allow for its classification as either acute undifferentiated leukemia or mixed phenotype acute leukemia, and definitive classification along a single lineage is difficult. (WHO 2017)


Unresectable Esophageal Carcinoma

description: A carcinoma that arises from the esophagus and is not amenable to surgical resection.


Papillary mucinous cystadenocarcinoma

description: An invasive adenocarcinoma characterized by cystic changes, papillary growth pattern, and the presence of malignant glandular cells which contain intracytoplasmic mucin.


name: Metastatic Primary Malignant Brain Neoplasm

description: A malignant neoplasm that arises from the brain and has spread from its original site of growth to other sites.


Gastric Hepatoid Adenocarcinoma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of large polygonal malignant cells with eosinophilic cytoplasm resembling hepatocytes.


Anal squamous cell carcinoma metastatic

description: Anal squamous cell carcinoma that has spread from its primary site to another anatomic site.


name: Recurrent Endometrial Clear Cell Adenocarcinoma

description: The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


Bone Sarcoma by AJCC v7 Stage

description: A term that refers to the staging of bone sarcoma, following the rules of the TNM AJCC v7 classification system.


CTRP Clinical Finding

description: A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


Fever of Unknown Origin

description: A febrile process with an etiology that is not apparent or yet determined.


name: Recurrent Large Cell Neuroendocrine Carcinoma

description: The reemergence of large cell neuroendocrine carcinoma after a period of remission.


Diffuse neurofibroma

description: A rare neurofibroma with an infiltrative growth pattern.  It involves the skin and subcutaneous tissue and grows in a plaque-like fashion.  Malignant transformation is rare.


Gastric Carcinoma with Lymphoid Stroma

description: A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures.


name: Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified

description: A myelodysplastic/myeloproliferative neoplasm that does not meet the criteria of other myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes, and myeloproliferative neoplasms. It is associated with cytopenia, blasts less than 20% in bone marrow and peripheral blood, thrombocytosis, and absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.


Naevus spider acquired

description: A non-congenital, benign vascular lesion with a central punctum (arteriole) that is surrounded by thin-walled capillaries in a radial pattern. It occurs as the result of the dilatation of pre-existing vessels and is most often an incidental finding. The lesion may also be found in association with hypermetabolic states or chronic disease.


name: Metastatic Malignant Neoplasm in the Pelvic Cavity

description: The spread of a malignant neoplasm from a primary site to the pelvic cavity.


name: Childhood Acute Lymphoblastic Leukemia CNS-Negative Toronto Guidelines v2

description: No clinical signs of CNS involvement and no blasts in CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Refractory Acute Undifferentiated Leukemia

description: Acute undifferentiated leukemia that does not respond to treatment.


Stage IV Urethral Cancer AJCC v8

description: Stage IV includes: (T4, N0, M0); (T4, N1, M0); (Any T, N2, M0); (Any T, Any N, M1). T4: For male penile urethra and female urethra: Tumor invades other adjacent organs (e.g., invasion of the bladder wall). For prostatic urethra: Tumor invades other adjacent organs (e.g., extraprostatic invasion of the bladder wall, rectal wall). N0: No regional lymph node metastasis. N1: Single regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. N2: Multiple regional lymph node metastasis in the inguinal region or true pelvis [perivesical, obturator, internal (hypogastric) and external iliac], or presacral lymph node. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Parainfluenza Virus Infections

description: A viral infection caused by a parainfluenza virus, typically resulting in infections of the lower respiratory tract.


name: Skin disorder arising from mental factors

description: A skin disorder for which mental factors play a causative role.


Aleukemic myeloid leukemia

description: Myeloid leukemia presenting with leukemic infiltration of tissues and normal or decreased leukocyte count in the peripheral blood.


Virus-Related Carcinoma

description: Carcinoma that develops in the context of an individual infected with a virus.


Vulvar Melanocytic Nevus

description: A benign, atypical, or dysplastic melanocytic nevus that arises from the vulva.


Enterotoxigenic E coli Infection

description: A pathotype of Escherichia coli, which is a gram-negative bacteria that is transmitted through the fecal-oral route. It has an incubation period of 10-72 hours and a duration of 1-5 days. Symptoms may include acute, occasionally severe diarrhea without fever.


name: Intestinal Metaplasia of Bladder Urachal Epithelium


name: Complete Atrioventricular Canal Defect Balanced

description: Atrioventricular septal defect in which the atrioventricular junction is shared evenly between the left ventricle and right ventricle.


Benign Liver Non-Epithelial Neoplasm

description: A non-epithelial neoplasm that arises from the liver and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hemangioma, angiomyolipoma, and solitary fibrous tumor.


Endometrioid intraepithelial neoplasia

description: A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations.


name: AIDS-Related Malignant Cervical Neoplasm

description: A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Pericarditis secondary to uremia

description: Inflammation of the pericardium associated with chronic kidney failure.


Refractory Chronic Leukemia

description: Chronic leukemia that is resistant to treatment.


Testicular cancer metastatic

description: A malignant germ cell tumor that arises from the testis and has spread to another anatomic site.


name: Non-Functioning Pancreatic Neuroendocrine Tumor G1

description: A low grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome.


name: Childhood Connective and Soft Tissue Neoplasm

description: A soft tissue or bone neoplasm that occurs during childhood.


name: Arterial Thrombosis Related to Vascular Access Complication

description: The formation of a thrombus in the artery as a direct result of an activity associated with vascular access.


name: Lugano Classification Stage I Hodgkin Lymphoma AJCC v8

description: Stage I: Involvement of a single lymphatic site (i.e., nodal region, Waldeyer's ring, thymus, or spleen). (from AJCC 8th Ed.)


name: Malignant Osteoclastic Giant Cell-Rich Tumor of Bone

description: A giant cell tumor that arises from the bone and is characterized by the presence of a malignant cellular component.


name: Refractory Sclerodermatous Graft Versus Host Disease

description: Sclerodermatous Graft Versus Host Disease that is resistant to treatment.


Infectious Encephalomyelitis

description: An infectious process that affects the brain and spinal cord tissues. It is usually caused by viruses.


Acral nevus

description: A melanocytic nevus that arises from the palms, soles, and nails.


name: Early T Precursor Acute Lymphoblastic Leukemia with BCL11B Rearrangement

description: An early T precursor acute lymphoblastic leukemia associated with the presence of BCL11B gene rearrangement.


Stage IIA2 Cervical Cancer AJCC v8

description: Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Acute Myeloid Leukemia with STAG2 Mutation

description: An acute myeloid leukemia associated with STAG2 gene mutation.


Liver Germ Cell Tumor

description: A benign or malignant extragonadal germ cell tumor that arises from the liver. Representative examples include teratoma and yolk sac tumor.


name: Refractory Fallopian Tube Mucinous Adenocarcinoma

description: Fallopian tube mucinous adenocarcinoma that is resistant to treatment.


name: Borrelia Burgdoferi-Associated Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

description: Primary cutaneous marginal zone lymphoproliferative disorder that arises from chronically stimulated lymphoid tissue in the skin in response to Borrelia burgdoferi infection.


Indirect Contact Transmission Infection

description: Infection transmitted by water, food or other means of conveyance.


Interstitial Disease

description: A disease occurring chiefly in the connective-tissue framework of an organ.


Adolescent Gynecomastia

description: Gynecomastia that occurs during puberty and is not due to exogenous substances or disease processes.


name: Anal Canal Cancer by AJCC v6 and v7 Stage

description: A term that refers to the staging of anal canal cancer according to the American Joint Committee on Cancer, 6th and 7th editions. This staging system applies to carcinomas arising in the anal canal only; melanomas, carcinoid tumors, sarcomas, and perianal tumors are not included. (from AJCC 6th and 7th Eds.)


name: Refractory T Acute Lymphoblastic Leukemia

description: T-acute lymphoblastic leukemia that does not respond to treatment.


Metastatic Acral Lentiginous Melanoma

description: Acral lentiginous melanoma that has spread from its original site of growth to another anatomic site.


Unresectable Solid Neoplasm

description: A solid neoplasm that is not amenable to surgical resection.


name: Human Papillomavirus-Related Vaginal Adenocarcinoma

description: An adenocarcinoma that arises from the vagina and is caused by human papillomavirus infection.


name: Recurrent HIV-Related Lymphoproliferative Disorder

description: The reemergence of HIV-associated lymphoproliferative disorder after a period of remission.


name: Testicular Spermatocytic Tumor with Sarcoma

description: A malignant germ cell tumor that arises from the testis and is characterized by the presence of a spermatocytic tumor component that is contiguous with an undifferentiated or differentiated sarcomatous component.  It usually presents as a slowly growing mass that enlarges very rapidly soon after the initial diagnosis.


name: Metastatic Gastric Neuroendocrine Carcinoma

description: A gastric neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site.


name: Progesterone Receptor-Positive Malignant Neoplasm

description: A malignant neoplasm that is positive for progesterone receptors.


description: Myelofibrosis that develops in a patient with history of essential thrombocythemia.


name: Locally Advanced Digestive System Carcinoma

description: Digestive system carcinoma that has spread to nearby tissues or lymph nodes.


Metastatic Benign Neoplasm

description: A very rare benign neoplasm that metastasizes inexplicably. This category includes metastasizing pleomorphic adenoma of the salivary gland and uterine corpus metastasizing leiomyoma.


name: Refractory Low Grade Fallopian Tube Serous Adenocarcinoma

description: Low grade fallopian tube serous adenocarcinoma that is resistant to treatment.


name: Refractory Malignant Urinary System Neoplasm

description: Malignant urinary system neoplasm that is resistant to treatment.


Signet Ring Melanoma

description: A rare variant of cutaneous melanoma, characterized by the presence of malignant cells with signet-ring morphology.


Junctional melanocytic nevus of skin

description: A nevus characterized by the presence of an intraepidermal proliferation of nevus cells. The nevus cells form multiple nests in the dermal-epidermal junction. It presents as a small, slightly raised, pigmented skin lesion.


Mucosal lentiginous melanoma

description: An acral lentiginous melanoma affecting mucosal surfaces.


Childhood Junctional Nevus

description: A junctional nevus that occurs during childhood.


Hypoxic-Ischemic Encephalopathy

description: Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.


Adult Grade III Meningioma

description: A grade III meningioma that occurs during adulthood.


Grade I Meningioma

description: A benign meningioma which may recur in approximately 7-20% of the cases.  This category includes the angiomatous meningioma, fibrous meningioma, lymphoplasmacyte-rich meningioma, meningothelial meningioma, metaplastic meningioma, microcystic meningioma, psammomatous meningioma, secretory meningioma, and transitional meningioma.


Stage II Vulvar Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Phantom Limb Syndrome

description: Paresthesia or discomfort experienced post-amputation.


Recurrent Laryngeal Nerve Paralysis

description: Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis.


name: Recurrent Central Nervous System Lymphoma

description: The reemergence of central nervous system lymphoma after a period of remission.


Kidney Paraganglioma

description: An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category.


name: Digestive System Neuroendocrine Tumor G2

description: A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.


name: High Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of masses of mucin within the affected distended glands.


name: Stage M0 Childhood Ependymoma by Toronto Guidelines v2

description: No visible disease on imaging (MRI brain and spine) beyond primary site of disease and no tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Malignant neoplasm of stomach recurrent

description: The reemergence of a malignant neoplasm of the stomach after a period of remission.


Stage I Cervical Cancer AJCC v8

description: Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


Blastic Granulocytic Sarcoma

description: A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001).


Childhood NUT Carcinoma

description: A NUT carcinoma that occurs during childhood.


name: Lobular Endocervical Glandular Hyperplasia

description: Lobular proliferations of benign-appearing small to moderate sized endocervical glands in the inner half of the cervical stroma. The glands are lined by columnar epithelial cells which contain pyloric gland-type mucin. There is minimal atypia and mitotic figures are rare. Some cases have been associated with adenocarcinoma in situ/high grade cervical glandular intraepithelial neoplasia and gastric-type adenocarcinomas.


Paratesticular Serous Cystadenoma

description: A rare serous cystadenoma that arises from the paratesticular structures.


name: Clonal Cytopenia with Monocytosis of Undetermined Significance

description: A myelodysplastic/myeloproliferative neoplasm that fulfills the diagnostic criteria of clonal monocytosis of undetermined significance and is associated with cytopenia.


Stage II Pancreatic Cancer AJCC v8

description: Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor measuring 2 cm or less in greatest dimension. T2: Tumor measuring more than 2 cm and 4 cm or less in greatest dimension. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in one to three regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Radiation-Related Osteosarcoma

description: A high grade osteosarcoma arising in an irradiated bone.


recurrent adult acute myeloid leukemia

description: The reemergence of acute myeloid leukemia in adults after a period of remission.


name: No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Pancreatic Intraductal Neoplasms

description: A group of cystic or mass-forming epithelial neoplasms that arise from the exocrine pancreas, exhibit ductal differentiation, and grow mostly within the pancreatic ducts.  This group includes the pancreatic intraductal papillary mucinous neoplasms and the pancreatic intraductal tubulopapillary neoplasms.


Great vessel abnormalities

description: A congenital vascular abnormality that affects the great vessels and/or aortic arch. Representative examples include double aortic arch, aortic coarctation, and absence of a pulmonary artery.


Stage I Appendix Carcinoma AJCC v7

description: Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Radiation-Induced Vascular Disease

description: A vascular disease caused by radiation.


name: Metastatic Sarcomatoid Urothelial Carcinoma

description: Sarcomatoid urothelial carcinoma that has spread to another anatomical site.


name: Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8

description: Stage IIIB includes: (T3, N1, M0); (T0-3, N2, M0); (T4a, N0, M0). T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Gangliocytoma

description: The reemergence of gangliocytoma after a period of remission.


Gallbladder Neuroendocrine Tumor G3

description: A well differentiated, high grade neoplasm with neuroendocrine differentiation that arises from the gallbladder. The Ki-67 index is higher than 20%.


name: Blood coagulation disorder due to liver disease

description: A disorder of blood clotting that is attributable to a deficiency in liver function.


Pathological Gynecomastia

description: Gynecomastia that is due to exogenous substances or disease processes.


Pedunculated conjunctival papilloma

description: A papilloma that arises from the conjunctival squamous epithelium. It is associated with human papillomavirus infection.


Benign Intracranial Neoplasm

description: A neoplasm that involves the intracranial area and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)


Chronic Insomnia

description: Insomnia that has persisted at least one month.


New Onset Diabetes After Transplant

description: Development of diabetes after transplant, usually associated with calcineurin inhibitor use.


Localized Prostate Carcinoma

description: A carcinoma that arises from the prostate and has not spread to other anatomic sites.


name: Benign Ovarian Partly Luteinized Thecoma


name: Metastatic Malignant Nongerminomatous Germ Cell Tumor

description: A malignant nongerminomatous germ cell tumor that has spread from its original site of growth to another anatomic site.


Recurrent Meningioma

description: The reemergence of a meningioma after a period of remission.


Well Differentiated Malignant Neoplasm

description: A malignant neoplasm with morphological features reminiscent of the tissue from which it arose.


name: Ampulla of Vater Neuroendocrine Neoplasm

description: A neoplasm with neuroendocrine differentiation that arises from the ampulla of Vater and periampullary region. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms).


Ovarian Leydig Cell Hyperplasia

description: An increased number of Leydig cells in the hilar region of the ovary. (WHO 2020)


Stage IV Merkel Cell Carcinoma AJCC v7

description: Stage IV includes: Any T, Any N, M1.  M1: Metastasis beyond regional lymph nodes. (AJCC 7th Ed.)


Stage 0 Anal Cancer AJCC v8

description: Stage 0 includes: Tis, N0, M0. Tis: High-grade squamous intraepithelial lesion (previously termed carcinoma in situ, Bowen disease, anal intraepithelial neoplasia II-III, high-grade anal intraepithelial neoplasia). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Metastatic Endometrial Carcinoma

description: A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


name: Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma


Digestive System Hodgkin Lymphoma

description: A Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site.


Refractory Skin Squamous Cell Carcinoma

description: Skin squamous cell carcinoma that does not respond to treatment.


name: Simple Hamartoma of the Retinal Pigment Epithelium

description: A retinal hamartoma that involves only the retinal pigment epithelium. (WHO 2018)


Acute Myeloid Leukemia with del(17p)

description: Acute myeloid leukemia associated with deletion of the short arm of chromosome 17 [del(17p)].


mCode Non-Neoplastic Disease/Finding

description: Terminology related to non-neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


name: Extragonadal primary germ cell tumor mixed stage II


Refractory Myxoid Liposarcoma

description: Myxoid liposarcoma that does not respond to treatment.


name: Esophageal Adenocarcinoma by AJCC v7 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 7th edition.


Subcutaneous Disorder

description: A disorder of the subcutaneous tissue.


name: Undersocialized conduct disorder, aggressive type


name: Locally Advanced Biliary Tract Carcinoma

description: Carcinoma that arises from the intrahepatic, hilar, extrahepatic bile ducts, cystic duct, or gallbladder and has spread to nearby tissues or lymph nodes.


name: Refractory Endometrial Transitional Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


Recurrent Appendix Carcinoma

description: The reemergence of appendix carcinoma after a period of remission.


Kidney Schwannoma

description: A rare schwannoma arising from the kidney.


Childhood Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that occurs during childhood.


Congenital complete heart block

description: A disorder characterized by an electrocardiographic finding of a complete atrioventricular block that manifests during fetal life or soon after birth. It may be isolated or associated with other congenital heart defects. Isolated congenital complete atrioventricular block may be associated with maternal connective tissue disorders.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 2

description: Dyskeratosis congenita caused by mutation(s) in the TERT gene, encoding telomerase reverse transcriptase.


name: Appendix Neuroendocrine Tumor by AJCC v7 Stage

description: A term that refers to the staging of an appendiceal neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system.


name: Lugano Classification Stage IE Childhood Hodgkin Lymphoma AJCC v8

description: Stage IE: Single extralymphatic site in the absence of nodal involvement (rare in Hodgkin lymphoma). (from AJCC 8th Ed.)


Metaplastic meningioma

description: A WHO grade I meningioma characterized by the presence of a prominent mesenchymal component. The mesenchymal component may be osseous, cartilaginous, myxoid, lipomatous, or a mixture of mesenchymal elements.


name: Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8

description: Stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Stage IV Bone Cancer AJCC v7

description: Stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G).  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M1a: Distant metastasis to lung.  M1b: Metastasis to other distant sites. (AJCC 7th ed.)


Childhood Blue Nevus

description: A blue nevus that occurs during childhood.


Joint Tuberculosis

description: Tuberculosis affecting a joint.


Ureter Cancer by AJCC v7 Stage

description: A term that refers to the staging of ureter cancer according to the American Joint Committee on Cancer, 7th edition.


Foregut Neuroendocrine Tumor G1

description: A neuroendocrine tumor that arises from the esophagus, stomach, or duodenum.


Stage IIIA Gallbladder Cancer AJCC v7

description: Stage IIIA includes: T3, N0, M0. T3: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


Polycythaemia (excl rubra vera)

description: An increase in the concentration of red blood cells (hemoglobin) that is not caused by polycythemia vera.


name: Stage IIIC Uterine Corpus Cancer AJCC v8

description: Stage IIIC includes: IIIC1: T1-T3, N1/N1mi/N1a, M0; IIIC2: T1-T3, N2/N2mi/N2a, M0. T1: Uterine corpus carcinoma or carcinosarcoma with tumor confined to the corpus uteri, including endocervical glandular involvement. T2: Uterine corpus carcinoma or carcinosarcoma with tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus. Does not include endocervical glandular involvement. T3: Uterine corpus carcinoma or carcinosarcoma with tumor involving serosa, adnexa, vagina, or parametrium. N1: Regional lymph node metastasis to pelvic lymph nodes. N1mi: Regional lymph node metastasis (greater than 0.2 mm but nor greater than 2.0 mm in diameter) to pelvic lymph nodes. N1a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to pelvic lymph nodes. N2: Regional lymph node metastasis to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2mi: Regional lymph node metastasis (greater than 0.2 mm but not greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. N2a: Regional lymph node metastasis (greater than 2.0 mm in diameter) to para-aortic lymph nodes, with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 8th Ed.)


description: Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections.


Corneal dellen

description: Corneal thinning just anterior to the limbus secondary to abnormal and/or irregular bulbar conjunctival contour.


Spindle cell melanoma, type B

description: A melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli. Representative example is the type B spindle cell uveal melanoma.


name: Esophageal Adenocarcinoma by AJCC v8 Stage

description: A term that refers to the staging of esophageal adenocarcinoma according to the American Joint Committee on Cancer, 8th edition.


Naevus Lipomatosus Superficialis

description: A rare developmental anomaly characterized by the presence of ectopic adipose tissue within the upper half of the dermis. (WHO 2018)


name: asymptomatic carrier of alpha-thalassemia

description: A condition in which a person has reduced protein production from one of the four alpha-globin alleles.


Stage IIIC Cervical Cancer FIGO 2018

description: Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


Recurrent Severe Aplastic Anemia

description: The reemergence of severe aplastic anemia after a period of remission.


name: Recurrent Pancreatic Neuroendocrine Carcinoma

description: The reemergence of pancreatic neuroendocrine carcinoma after a period of remission.


Stage II Cervical Cancer FIGO 2018

description: The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Low Grade Osteosarcoma

description: An osteosarcoma with low-grade morphological features. This category includes parosteal osteosarcoma and low-grade central osteosarcoma.


Obstructed femoral hernia

description: The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis.


description: Tuberculosis disease that is caused by a pre-extensively drug-resistant strain of Mycobacterium tuberculosis.


Non-Neoplastic Pancreatic Disorder

description: A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


name: Platelet Disorder, Familial, with Associated Myeloid Malignancy

description: An autosomal dominant condition caused by mutation(s) in the RUNX1 gene, encoding runt-related transcription factor 1. It is characterized by thrombocytopenia, abnormal platelet function, and a propensity to develop acute myeloid leukemia.


Sporadic Gastric Diffuse Adenocarcinoma

description: A sporadic adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations.


Cesarean Scar Pregnancy

description: An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.


Geleophysic Dysplasia 1

description: An autosomal recessive condition caused by mutation(s) in the ADAMTSL2 gene, encoding ADAMTS-like protein 2. It is characterized by severe short stature, short hands and feet, skin thickening, and variable cardiorespiratory abnormalities.


Kir6.2-Associated Diabetes Mellitus

description: Diabetes mellitus caused by activating mutation(s) in the KCNJ11 gene, encoding the inwardly rectifying Kir6.2 subunit of the pancreatic beta cell adenosine triphosphate-sensitive potassium channel. Note: Inactivating mutation(s) in the KCNJ11 gene result in hyperinsulinism.


Congenital neuropathy

description: Neuropathy, the cause of which is present at birth.


Recurrent Ureter Carcinoma

description: The reemergence of ureter carcinoma after a period of remission


Cystitis Cystica and Glandularis

description: A reactive inflammatory disorder affecting the bladder.  It is characterized by the development of small cysts in the bladder wall.  The cysts are lined by urothelial cells and metaplastic glandular cells.


Non-Neoplastic Gallbladder Disorder

description: A non-neoplastic disorder that affects the gallbladder. Representative examples include cholecystitis and adenomyomatosis.


name: Stage III Low Grade Adult Non-Hodgkin's Lymphoma


True Thymic Hyperplasia

description: An increase in gross volume and weight of the thymus gland, with maintenance of normal lobular architecture, and preservation of corticomedullary differentiation.


name: Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type

description: An X-linked recessive condition caused by mutation(s) in the UBE2A gene, encoding ubiquitin-conjugating enzyme E2 A. It is characterized by facial dysmorphisms and intellectual impairment.


name: Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

description: A malignant peripheral nerve sheath tumor characterized by the presence of mesenchymal differentiation.  Representative example is the malignant Triton tumor which contains a rhabdomyosarcomatous component.


name: Non-Inflammatory Female Reproductive System Disorder

description: A non-inflammatory disorder that affects the female reproductive system.


Bisphosphonate-associated osteonecrosis

description: Necrosis of the mandible or maxilla in patients receiving intravenous or oral bisphosphonate therapy.  It usually manifests with slow healing or failure to heal of a jaw bone following oral surgery.  In a minority of cases, the necrosis appears spontaneously.  Signs and symptoms include pain, swelling and infection of the affected area.


Benign Extragonadal Germ Cell Tumor

description: A germ cell tumor that arises from an anatomic site other than the testis or ovary. There is no evidence of atypia or metastases.


name: Unspecified nonpsychotic mental disorder following organic brain damage

description: Any mental disorder that occurs secondary to organic brain damage, and that is not associated with psychosis.


name: Refractory Endometrial Squamous Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


name: Kidney Mixed Epithelial and Stromal Tumor Family

description: A family of tumors ranging from predominantly cystic tumors (adult cystic nephromas) to tumors that are variably solid (mixed epithelial and stromal tumors) and contain biphasic epithelial and stromal components with spindle stroma, glands, and cysts. Most of these tumors are benign. (WHO 2016).


description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the skin.


Refractory Pancreatic Adenocarcinoma

description: Pancreatic adenocarcinoma that is resistant to treatment.


name: Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for nodular sclerosis classic Hodgkin lymphoma based on the Ann Arbor classification criteria.


Cervical Meningocele

description: A congenital abnormality in the cervical region of the spine in which the meninges protrude through a defect in the spinal column.


Primary Cold Agglutinin Disease

description: A clonal B-cell lymphoproliferative disease of the bone marrow that results in autoimmune hemolytic anemia. It is distinct from lymphoplasmacytic lymphoma and IgM monoclonal gammopathy of undetermined significance. It lacks MYD88 gene mutation and is associated with trisomies of chromosomes 3, 12, and 18, and mutations in KMT2D and CARD11 genes.


name: Recurrent High Grade Endometrioid Adenocarcinoma

description: The reemergence of high-grade endometrioid adenocarcinoma after a period of remission.


name: Acute Myeloid Leukemia with t(11;17)(q23;q21); ZBTB16-RARA

description: Acute myeloid leukemia with the variant RARA t(11;17)(q23;q21) and the expression of ZBTB16-RARA fusion protein.  It lacks differentiation response to retinoids treatment.


Advanced cancer

description: A malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


Dermal Spitz Nevus

description: A Spitz nevus characterized by the presence of an intradermal melanocytic component without junctional melanocytic activity.


Borderline Paratesticular Serous Tumor

description: A rare, non-invasive, serous cystic tumor that arises from the paratesticular structures. It is characterized by the presence of irregular papillary formations with irregular branching. The papillae are lined by atypical columnar epithelial cells with eosinophilic cytoplasm. Mitoses are rare. Metastases have not been reported.


name: Adult Nodular Sclerosis Classical Hodgkin Lymphoma

description: Nodular sclerosis classic Hodgkin lymphoma occurring in adults.


Chronic Myelomonocytic Leukemia-0

description: A chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood.


name: Diffuse malignant lymphoma - large non-cleaved cell

description: Antiquated term for diffuse non-Hodgkin lymphomas composed of non-cleaved cells.  The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas).


Trichoblastic carcinoma

description: A rare biphasic malignant neoplasm with dual differentiation towards the specialized follicular stroma and germinative follicular cells, which can be strikingly atypical. (WHO 2018)


name: Acute Myeloid Leukemia with t(11;19)(q23.3;p13.1); KMT2A-ELL

description: An acute myeloid leukemia associated with t(11;19)(q23.3;p13.1) resulting in KMT2A-ELL gene fusion.


name: Stage IB Pancreatic Cancer AJCC v6 and v7

description: Stage IB includes: T2, N0, M0. T2: Tumor limited to the pancreas, more than 2 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (from AJCC 7th Ed.)


name: Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A

description: An acute myeloid leukemia associated with t(10;11)(q21.3;q23.3) resulting in TET1-KMT2A gene fusion.


Pre-Malignant Skin Epithelial Lesion

description: A term that refers to precancerous epithelial pathologic processes that affect the skin.


name: Reactive lymphoid hyperplasia of lacrimal gland

description: A polyclonal proliferation of lymphoid tissue in the lacrimal gland. It usually presents as painless palpable masses leading to globe displacement, decreased motility, diplopia, and ptosis. It has a tendency to involve bilateral lacrimal glands. There is a higher incidence in females and in the setting of autoimmune disease. (WHO 2018)


Sign or Symptom

description: Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

description: A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


name: Asymptomatic human immunodeficiency virus infection

description: An infection caused by human immunodeficiency virus (HIV) that is asymptomatic at the time of testing.


name: 21-hydroxylase deficiency - simple virilizing

description: A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


name: PERSISTENT MULLERIAN DUCT SYNDROME, TYPE I

description: Persistent Mullerian duct syndrome due to deficiency of anti-Mullerian hormone.


Recurrent Cervical Adenocarcinoma

description: The reemergence of cervical adenocarcinoma after a period of remission.


Chronic diastolic heart failure

description: Chronic congestive heart failure due to a left ventricle which does not fill properly due to decreased compliance though the ejection fraction may be preserved.


name: Non-Invasive Pancreatic Mucinous-Cystic Neoplasm

description: A cystic epithelial neoplasm that arises from the pancreas and is characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component.


Refractory Malignant Lymphoid Neoplasm

description: A malignant lymphoid neoplasm that does not respond to treatment.


Splenic thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the splenic vein or splenic artery.


Stage I Osteosarcoma AJCC v7

description: Stage I includes: IA (T1, N0, M0, G1, G2, GX); IB (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


Combined BAP1-inactivated melanocytoma

description: A BAP1-inactivated melanocytoma that is combined with a smaller area of melanocytic proliferation in the basal layer of the epidermis.


Acne aggravated

description: A flare of acne which may be precipitated by variety of factors, including hormonal activity, stress, oils and oily cosmetics, sweat, overwashing, and certain foods and drugs.


Malignant glioma of brain

description: A grade 3 or 4 glioma that arises from the brain. This category includes anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma (all grade 3 gliomas), and glioblastoma (grade 4 glioma).


name: Adenocarcinoma in situ in adenomatous polyp

description: A non-invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp.


Pseudoepitheliomatous hyperplasia

description: A benign lesion characterized by epidermal and adnexal epithelial hyperplasia.  It is caused by chronic inflammation and infection.  It may be associated with cutaneous neoplasms as well.


name: Cervical Squamous Intraepithelial Neoplasia 1

description: Cervical squamous intraepithelial neoplasia characterized by the presence of maturation in the upper two-thirds of the squamous epithelium and mild nuclear atypia which is present in all epithelial layers.  Mitotic figures are present in the basal third of the epithelium.


Cerebral Hemangioblastoma

description: A hemangioblastoma that arises from the cerebrum.


name: Hodgkin's disease lymphocyte predominance type stage IV

description: Stage IV adult Hodgkin disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)


Recurrent Intracranial Neoplasm

description: The reemergence of an intracranial neoplasm after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

description: A non-neoplastic disorder that affects the eye.


description: Esophageal adenocarcinoma that has metastasized to a limited number of sites.


name: New Onset Atrial Fibrillation Related to COVID-19

description: Newly occurring atrial fibrillation (AF) in a patient with probable or confirmed acute COVID-19. It is further categorized as first detected AF, paroxysmal AF (self-terminating within seven days of recognized onset), or persistent AF (not self-terminating within seven days).


Blood and lymphatic system disorders

description: A non-neoplastic or neoplastic disorder that affects the hematopoietic and lymphatic system.


Metastatic Cervical Carcinoma

description: A carcinoma of the cervix that has spread to another anatomic site.


Symptom

description: Subjective evidence of disease perceived by the patient.


name: MYOD1-Mutant Spindle Cell/Sclerosing Rhabdomyosarcoma

description: Spindle cell/sclerosing rhabdomyosarcoma characterized by the presence of MYOD1 p.Leu122Arg substitution mutation. This subtype includes most spindle cell/sclerosing rhabdomyosarcomas in adolescents and young adults, as well as some cases in older adults. It follows an aggressive clinical course.


name: Metastatic Bladder Lipid-Rich Urothelial Carcinoma

description: Bladder lipid-rich urothelial carcinoma that has spread to another anatomic site.


name: Hodgkin's disease nodular sclerosis stage II supradiaphragmatic


Refractory Adnexal Carcinoma

description: Adnexal carcinoma that is resistant to treatment.


name: 46,XX/46,XY Ovotesticular Differences of Sex Development

description: Ovotesticular differences of sex development in individuals with 46,XY/46,XX mosaic karyotype.


Acute Pericarditis Related to COVID-19

description: Acute pericarditis in a patient with probable or confirmed acute COVID-19.


name: Low Grade Esophageal Glandular Intraepithelial Neoplasia

description: A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal glandular epithelium.


Cryptococcal gastroenteritis

description: Gastroenteritis resulting from an infection with cryptosporidium.


Unresectable Gastric Carcinoma

description: A gastric carcinoma that is not amenable to surgical resection.


name: Recurrent Fallopian Tube Endometrioid Adenocarcinoma

description: The reemergence of fallopian tube endometrioid adenocarcinoma after a period of remission.


Gnathoschisis

description: A congenital abnormality consisting of clefting in the jaw, which results from incomplete fusion of the embryonic mandibular prominence.


Non-Neoplastic Bone Disorder

description: A non-neoplastic disorder that affects the bone or articular cartilage.


Adult Ganglioneuroma

description: A ganglioneuroma that occurs in adults.


Nonerosive Arthritis

description: An inflammation of one or more joints, without loss of articular cartilage or destruction of subchondral bone.


name: Complete Atrioventricular Septal Defect with Tetralogy of Fallot

description: A rare congenital heart anomaly in which there is coexistence of tetralogy of Fallot and complete atrioventricular septal defect. The latter is characterized by defects in the atrial and ventricular septa and a common atrioventricular valve.


name: Gallbladder Adenocarcinoma, Biliary Type

description: A well or moderately differentiated adenocarcinoma that arises from the gallbladder.  It is the most common type of gallbladder carcinoma and is characterized by the presence of malignant tubular glands.  Intestinal differentiation may be present.


Locally Advanced Unresectable Sarcoma

description: A sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Recurrent Low Grade Glioma

description: The reemergence of low grade glioma after a period of remission.


name: Non-Neoplastic Endocrine Pancreas Disorder

description: A non-neoplastic disorder that affects the endocrine pancreas.


name: Invasive Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma that exhibits squamous differentiation.


Chronic Lymphoblastic Lymphoma

description: This is an invalid term; lymphoblastic lymphomas are not chronic processes, but counterparts of acute lymphoblastic leukemias.


Lip Infection

description: An acute or chronic infectious process affecting the lips.


name: Endometrioid Adenocarcinoma of the Urinary Tract

description: An exceptionally rare endometrioid adenocarcinoma that arises from the urinary tract. It occurs in middle-aged and elderly females. It is associated with genitourinary endometriosis and has been described in the bladder and ureter.


Brain Development Abnormality

description: A group of congenital or acquired disorders that affect the normal development of the brain.


name: Invasive Micropapillary Urothelial Carcinoma

description: Invasive urothelial carcinoma exhibiting micropapillary growth pattern.


Allergic arthritis

description: Arthritis occurring after the ingestion of allergenic substance(s).


Congenital deformity of hip joint

description: Any anatomic abnormality of the hip that is present at the time of birth.


name: Severe Gastrointestinal Tract Acute Graft Versus Host Disease

description: Graft versus host disease occurring in the gastrointestinal tract and is characterized by complications that may be life-threatening.


name: Pathologic Stage I Retinoblastoma AJCC v8

description: Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


Refractory Urinary System Carcinoma

description: Urinary system carcinoma that does not respond to treatment.


name: Recurrent Malignant Male Reproductive System Neoplasm

description: The reemergence of a malignant male reproductive system neoplasm after a period of remission.


name: Invasive Bladder Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits squamous differentiation.


name: Mixed Phenotype Acute Leukemia, T/Megakaryocytic

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of T-cell and megakaryocytic lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Conjunctival Melanoma In Situ

description: A term that refers to conjunctival melanocytic intraepithelial lesions with severe atypia involving close to full thickness of the epithelium or lesions with histologic characteristics of melanoma that lack documented evidence of subepithelial invasion.


Clinical Stage I Retinoblastoma AJCC v8

description: Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

description: A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.


name: Steroid Resistant Acute Graft Versus Host Disease

description: Acute graft versus host disease that is resistant to treatment with steroids.


name: Fallopian Tube Metaplastic Papillary Tumor

description: A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


Malignant Solid Neoplasm

description: A malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include carcinomas and sarcomas. Hematopoietic and lymphoid tissue malignancies are not considered solid neoplasms.


Recurrent Fallopian Tube Carcinoma

description: The reemergence of fallopian tube carcinoma after a period of remission.


Premalignant Neoplasm

description: A neoplasm that is composed of dysplastic cells and there is no morphologic evidence of infiltration of the surrounding tissues.


name: Non-Neoplastic Disorder by Special Category


ROSE Cluster 1

description: Gene expression cluster 1 as determined by Recognition of Outliers by Sampling Ends (ROSE) in high-risk B-precursor acute lymphoblastic leukemia.


Recurrent Nervous System Neoplasm

description: The reemergence of a nervous system neoplasm after a period of remission.


Astler-Coller C1 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: Refractory T-Cell Large Granular Lymphocyte Leukemia

description: T-cell large granular lymphocyte leukemia that is resistant to treatment.


Hereditary Malignant Neoplasm

description: Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Occlusion of inferior vena cava

description: Blockage of the lumen of the inferior vena cava.


name: Lugano Classification Advanced Stage Adult Lymphoma AJCC v8

description: Advanced stage adult lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Monogenic Hyperinsulinism

description: A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Cervix carcinoma recurrent

description: The reemergence of cervical carcinoma after a period of remission.


Cancer of Urinary Tract

description: A primary or metastatic malignant neoplasm involving the urinary tract.


Ectopic ureter

description: A congenital anomaly in which the ureteral orifice drains into an abnormal location.


Advanced Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

description: A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


name: Extended Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that eventually involves more than four separate joints.


name: Staphylococcal arthritis and polyarthritis


name: Intellectual Disability, Autosomal Dominant 4

description: An autosomal dominant condition caused by mutation(s) in the CHAMP1 gene, encoding chromosome alignment-maintaining phosphoprotein 1. It is characterized by moderate to severe intellectual disability with poor speech acquisition. Variable dysmorphic features may be present as well.


Neoplasm of lacrimal drainage system

description: A benign or malignant neoplasm that affects the lacrimal drainage system.


Ovarian Infection

description: An infectious process affecting the ovary.


name: Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Invasive Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Occupational Malignant Neoplasm

description: Malignant neoplasm secondary to occupational exposure to carcinogens.


Neuroendocrine cervical carcinoma

description: A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Acute Stroke Related to COVID-19

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system in a patient with probable or confirmed acute COVID-19.


name: Verrucous carcinoma of the oral cavity stage IV


Supratentorial Meningioma

description: A meningioma that affects the supratentorial brain.


Glassy cell carcinoma

description: A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm.


name: Stage IIC Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Low grade appendiceal mucinous neoplasm

description: A well differentiated mucinous neoplasm that arises from the appendix.  It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei.


Genitourinary System Neoplasm

description: A benign or malignant neoplasm that affects the genitourinary system.


Urethral Cancer by AJCC v8 Stage

description: A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Diffuse Non-Pontine Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system, other than the pons.


name: Cerebral Venous Thrombosis Related to COVID-19


Perihepatic abscess

description: An abscess that is located in the anatomical space surrounding the liver, but which is outside of the liver capsule itself.