name: RARA_HUMAN Retinoic acid receptor alpha (sprot)

description: A retinoic acid receptor alpha that is encoded in the genome of human.


name: RARB_HUMAN Retinoic acid receptor beta (sprot)

description: A retinoic acid receptor beta that is encoded in the genome of human.


name: RXRB_HUMAN Retinoic acid receptor RXR-beta (sprot)

description: A retinoic acid receptor RXR-beta that is encoded in the genome of human.


name: RXRG_HUMAN Retinoic acid receptor RXR-gamma (sprot)

description: A retinoic acid receptor RXR-gamma that is encoded in the genome of human.


name: RABP1_HUMAN Cellular retinoic acid-binding protein 1 (sprot)

description: A cellular retinoic acid-binding protein 1 that is encoded in the genome of human.


name: RXRA_HUMAN Retinoic acid receptor RXR-alpha (sprot)

description: A retinoic acid receptor RXR-alpha that is encoded in the genome of human.


name: RABP2_HUMAN Cellular retinoic acid-binding protein 2 (sprot)

description: A cellular retinoic acid-binding protein 2 that is encoded in the genome of human.


name: NCOR2_HUMAN Nuclear receptor corepressor 2 (sprot)

description: A nuclear receptor corepressor 2 that is encoded in the genome of human.


tretinoin

A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.


PROTOCATECHUIC ACID

A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.


1,3-dimethyluric acid

An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trionesubstituted by methyl groups at N-1 and N-3.


p-CRESOL

A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.


paracetamol

A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.


PARAXANTHINE

A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals.


2-ethylacrylic acid

An alpha,beta-unsaturated monocarboxylic acid that is acrylic acid in which the hydrogen at position 2 is substituted by an ethyl group.


2-hydroxypentanoic acid

A 2-hydroxy monocarboxylic acid that is valeric (pentanoic) acid substituted at the alpha-position by a hydroxy group.


3,4-dihydroxymandelic acid

A catechol that is the 3,4-dihydroxy derivative of mandelic acid; a metabolite of L-dopa.


aminohippuric acid

An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.


benzoic acid

A compound comprising a benzene ring core carrying a carboxylic acid substituent.


(-)-Epicatechin

A catechin with (2R,3R)-configuration.


isobutyric acid

A branched fatty acid comprising propanoic acid carrying a methyl branch at C-2.


name: PPME1_HUMAN Protein phosphatase methylesterase 1 (sprot)

description: A protein phosphatase methylesterase 1 that is encoded in the genome of human.


METHYL ALCOHOL

The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.


valproic acid

A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.


thymol

A phenol that is a natural monoterpene derivative of cymene.


aspirin

A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.


DIHYDROXYACETONE

A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.


DIMETHYLFORMAMIDE

A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.


theophylline

A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.


acetylcysteine

An  N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.


name: PROS_HUMAN Vitamin K-dependent protein S (sprot)

description: A vitamin K-dependent protein S that is encoded in the genome of human.


name: PROZ_HUMAN Vitamin K-dependent protein Z (sprot)

description: A vitamin K-dependent protein Z that is encoded in the genome of human.


name: VKOR1_HUMAN Vitamin K epoxide reductase complex subunit 1 (sprot)

description: A vitamin K epoxide reductase complex subunit 1 that is encoded in the genome of human.


name: VKORL_HUMAN Vitamin K epoxide reductase complex subunit 1-like protein 1 (sprot)

description: A vitamin K epoxide reductase complex subunit 1-like protein 1 that is encoded in the genome of human.


menadione

A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.


name: familial isolated deficiency of vitamin E

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Ataxia with vitamin E deficiency (AVED) is a neurodegenerative disease belonging to the inherited cerebellar ataxias. It is mainly characterized by progressive spino-cerebellar ataxia, loss of proprioception, areflexia, and is associated with a marked deficiency in vitamin E.


name: TTPA_HUMAN Alpha-tocopherol transfer protein (sprot)

description: An alpha-tocopherol transfer protein that is encoded in the genome of human.


Vitamin E

An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.


name: TS1R3_HUMAN Taste receptor type 1 member 3 (sprot)

description: A taste receptor type 1 member 3 that is encoded in the genome of human.


name: TS1R2_HUMAN Taste receptor type 1 member 2 (sprot)

description: A taste receptor type 1 member 2 that is encoded in the genome of human.


ASPARTAME

A dipeptide zwitterion resulting from transfer of a proton from the carboxy to the amino group of aspartame; major species at pH 7.3.


salicylic acid

A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves.


name: migraine with or without aura, susceptibility to, 1


6-aminocaproic acid

An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.


1,25-dihydroxyvitamin D3

A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.


2-aminoisobutyric acid

A rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. With the exception of a few bacteria, it is non-metabolisable, and therefore used in bioassays.


omeprazole

A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.


alendronate

A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.


digoxin

A  cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.


LEVOMETHORPHAN

A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the stereocenters at positions 4a, 10 and 10a have R-configuration. It is a prodrug of levorphanol and a strong narcotic analgesic, and listed as a schedule II controlled substance.


metformin

A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.


name: ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 (sprot)

description: A disintegrin and metalloproteinase domain-containing protein 9 that is encoded in the genome of human.


name: AT5EL_HUMAN ATP synthase subunit epsilon-like protein, mitochondrial (sprot)

description: An ATP synthase subunit epsilon-like protein, mitochondrial that is encoded in the genome of human.


clotrimazole

A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.


naproxen

A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation  and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.


atenolol

An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.


ibuprofen

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.


ethinylestradiol

A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a  xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.


diphenhydramine

An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.


hydrochlorothiazide

A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.


name: TOP2A_HUMAN DNA topoisomerase 2-alpha (sprot)

description: A DNA topoisomerase 2-alpha that is encoded in the genome of human.


levofloxacin

An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.


ranitidine

A member of the class of  furans used to treat  peptic ulcer disease (PUD) and gastroesophageal reflux disease.


metoprolol

A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a  4-(2-methoxyethyl)phenoxy group at position 1.


furosemide

A  chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.


nicotine

A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.


warfarin

A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.


name: ACM1_HUMAN Muscarinic acetylcholine receptor M1 (sprot)

description: A muscarinic acetylcholine receptor M1 that is encoded in the genome of human.


IL8_HUMAN Interleukin-8 (sprot)

An interleukin-8 that is encoded in the genome of human.


salbutamol

A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).


ANGT_HUMAN Angiotensinogen (sprot)

An angiotensinogen that is encoded in the genome of human.


medroxyprogesterone

A 3-oxo Delta(4)-steroid that is pregn-4-ene-3,20-dione substituted by an alpha-hydroxy group at position 17 and a methyl group at position 6.


triamterene

Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.


brompheniramine

Pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.


An amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1S,2R-stereoisomer).


pseudoephedrine

A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group.


chlorpheniramine

A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.


3-hydroxyoctanoic acid

The (S)-enantiomer of 3-hydroxyoctanoic acid.


3-phenylbutyric acid

A monocarboxylic acid that is butanoic acid substituted by a phenyl group at position 3.


caffeic acid

The trans-isomer of caffeic acid.


name: DOPD_HUMAN D-dopachrome decarboxylase (sprot)

description: A D-dopachrome decarboxylase that is encoded in the genome of human.


carbon dioxide

A one-carbon compound with formula CO2 in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food.


name: AAAD_HUMAN Arylacetamide deacetylase (sprot)

description: An arylacetamide deacetylase that is encoded in the genome of human.


name: A4Z6T8_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6T9_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6U4_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6U6_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6U7_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6U9_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6V9_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6Y1_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6Y3_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z6Y5_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z737_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z787_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z7F6_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z7H3_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z7J7_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z7K4_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z7P9_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z7V0_HUMAN arylamine N-acetyltransferase (trembl)


name: A4Z867_HUMAN arylamine N-acetyltransferase (trembl)


name: Q400I7_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q400J6_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q6U7I7_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q9HAQ5_HUMAN arylamine N-acetyltransferase (trembl)


name: A9X868_HUMAN arylamine N-acetyltransferase (trembl)


name: A9X7X6_HUMAN arylamine N-acetyltransferase (trembl)


name: A9X7Q9_HUMAN arylamine N-acetyltransferase (trembl)


name: A9X854_HUMAN arylamine N-acetyltransferase (trembl)


name: A9X844_HUMAN arylamine N-acetyltransferase (trembl)


name: A9X7U6_HUMAN arylamine N-acetyltransferase (trembl)


name: A9X816_HUMAN arylamine N-acetyltransferase (trembl)


name: Q1HRY2_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q1HRY6_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q09LL5_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q5C8V2_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q1HRY5_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q1HRY3_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


name: Q1HRY4_HUMAN arylamine N-acetyltransferase (Fragment) (trembl)


The all-cis-isomer of a C22 polyunsaturated fatty acid having five double bonds in the 4-, 7-, 10-, 13- and 16-positions. It is a member of n-6 PUFA and a product of linoleic acid metabolism.


name: V2R_HUMAN Vasopressin V2 receptor (sprot)

description: A vasopressin V2 receptor that is encoded in the genome of human.


CUL5_HUMAN Cullin-5 (sprot)

A cullin-5 that is encoded in the genome of human.


name: NPSR1_HUMAN Neuropeptide S receptor (sprot)

description: A neuropeptide S receptor that is encoded in the genome of human.


name: Q9UEW6_HUMAN Vasopressin-neurophysin (Fragment) (trembl)


name: Q3S2J4_HUMAN Vasopressin V1a receptor (trembl)


name: Q9UH72_HUMAN V1-vascular vasopressin receptor AVPR1A (Fragment) (trembl)


name: Q16271_HUMAN Arginine vasopressin V2 receptor (Fragment) (trembl)


3,7-dimethyluric acid

An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by methyl groups at N-3 and N-7.


A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.


finasteride

An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.


2-hydroxy-2-methylbutyric acid

A branched-chain fatty acid that is 2-methylbutyric acid substituted at C-2 by a hydroxy group.


4-hydroxycyclohexanecarboxylic acid

A 4-hydroxy monocarboxylic acid that is cyclohexane substituted by a carboxy group at position 1 and a hydroxy group at position 4.


An oxopurine that is xanthine in which the hydrogen attached to the nitrogen at position 7 is replaced by a methyl group. It is an intermediate metabolite in the synthesis of caffeine.


A cholestanoid consisting of a cholesterol core having an oxo group at the 3-position, a C=C bond at the 4,5-position and an alpha-hydroxy group at the 7-position.


EPA

An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.


MYRISTOLEIC ACID

A tetradecenoic acid in which the double bond is at the 9-10 position and has Z configuration. Myristoleic acid has been isolated from Serenoa repens and has cytotoxic and apoptosis-inducing effects.


LIGNOCERIC ACID

A C24 straight-chain saturated fatty acid.


A tryptamine alkaloid that is N,N-dimethyltryptamine substituted by a methoxy group at position 5.


crotonoyl-CoA

The (E)-isomer of but-2-enoyl-CoA.


Coenzyme Q1

A compound composed of the standard 2,3-dimethoxy-5-methylbenzoquinone nucleus common to ubiquinones; and a side chain of a single isoprenoid unit.


O-butanoyl-L-carnitine

An optically active form of O-butanoylcarnitine having L-configuration.


An O-acylcarnitine having (5Z)-tetradecenoyl as the acyl substituent.


A phenylethylamine that is ethylamine substituted by a phenyl group at position 1.


TRANS-PHYTOL

A diterpenoid that is hexadec-2-en-1-ol substituted by methyl groups at positions 3, 7, 11 and 15.


IMIDAZOLE ACETIC ACID

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by an imidazol-4-yl group.


A fructosamine-3-kinase that is encoded in the genome of human.


KT3K_HUMAN Ketosamine-3-kinase (sprot)

A ketosamine-3-kinase that is encoded in the genome of human.


name: TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (sprot)

description: A G/T mismatch-specific thymine DNA glycosylase that is encoded in the genome of human.


An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.


para-coumaric acid

The trans-isomer of 4-coumaric acid.


ORTHOCRESOL

A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.


name: AMACR_HUMAN Alpha-methylacyl-CoA racemase (sprot)

description: An alpha-methylacyl-CoA racemase that is encoded in the genome of human.


pristanoyl-CoA

A multi-methyl-branched fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of pristanic acid.


CD44_HUMAN CD44 antigen (sprot)

A CD44 molecule that is encoded in the genome of human.


name: PGCA_HUMAN Aggrecan core protein (sprot)

description: An aggrecan core protein that is encoded in the genome of human.


name: TSG6_HUMAN Tumor necrosis factor-inducible gene 6 protein (sprot)

description: A tumor necrosis factor-inducible gene 6 protein that is encoded in the genome of human.


name: PGCB_HUMAN Brevican core protein (sprot)

description: A brevican core protein that is encoded in the genome of human.


name: CSPG2_HUMAN Versican core protein (sprot)

description: A versican core protein that is encoded in the genome of human.


name: U17LO_HUMAN Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 17-like protein 24 that is encoded in the genome of human.


name: HMMR_HUMAN Hyaluronan mediated motility receptor (sprot)

description: A hyaluronan mediated motility receptor that is encoded in the genome of human.


STAB2_HUMAN Stabilin-2 (sprot)

A stabilin-2 that is encoded in the genome of human.


name: IMPG2_HUMAN Interphotoreceptor matrix proteoglycan 2 (sprot)

description: An interphotoreceptor matrix proteoglycan 2 that is encoded in the genome of human.


name: LYVE1_HUMAN Lymphatic vessel endothelial hyaluronic acid receptor 1 (sprot)

description: A lymphatic vessel endothelial hyaluronic acid receptor 1 that is encoded in the genome of human.


name: HPLN1_HUMAN Hyaluronan and proteoglycan link protein 1 (sprot)

description: A hyaluronan and proteoglycan link protein 1 that is encoded in the genome of human.


name: HPLN2_HUMAN Hyaluronan and proteoglycan link protein 2 (sprot)

description: A hyaluronan and proteoglycan link protein 2 that is encoded in the genome of human.


name: HPLN3_HUMAN Hyaluronan and proteoglycan link protein 3 (sprot)

description: A hyaluronan and proteoglycan link protein 3 that is encoded in the genome of human.


name: HPLN4_HUMAN Hyaluronan and proteoglycan link protein 4 (sprot)

description: A hyaluronan and proteoglycan link protein 4 that is encoded in the genome of human.


STAB1_HUMAN Stabilin-1 (sprot)

A stabilin-1 that is encoded in the genome of human.


LAYN_HUMAN Layilin (sprot)

A layilin that is encoded in the genome of human.


name: SUSD5_HUMAN Sushi domain-containing protein 5 (sprot)

description: A sushi domain-containing protein 5 that is encoded in the genome of human.


name: HABP2_HUMAN Hyaluronan-binding protein 2 (sprot)

description: A hyaluronan-binding protein 2 that is encoded in the genome of human.


An amino disaccharide consisting of 2-acetamido-beta-D-glucopyranose and beta-D-glucopyranuronic acid residues joined in sequence by a (1->4)-glycosidic bond.


N-acetylputrescine

An N-monoacetylalkane-alpha,omega-diamine that is the N-monoacetyl derivative of putrescine.


ERUCIC ACID

A docosenoic acid having a cis- double bond at C-13. It is found particularly in brassicas - it is a major component of mustard and rapeseed oils and is produced by broccoli, Brussels sprouts, kale, and wallflowers.


4-hydroxy-2-oxoglutaric acid

An oxo dicarboxylic acid comprising glutaric acid having oxo- and hydroxy substituents at the 2- and 4-positions respectively.


bisnorcholic acid

A bile acid that is 24-dinor-5beta-cholan-22-oic acid bearing three hydroxy substituents at positions 3alpha, 7alpha and 12alpha.


cyanide

A pseudohalide anion that is the conjugate base of hydrogen cyanide.


SYRINGIC ACID

A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.


cobamamide

A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.


N-isovalerylsarcosine

An N-acyl-amino acid resulting from the formal condensation of carboxy group of isovaleric acid with the amino group of sarcosine.


N-oleoylethanolamide

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide.


ITACONATE

A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group.


O-malonyl-L-carnitine

An O-acyl-L-carnitine in which the acyl group is specified as malonyl.


B2MG_HUMAN Beta-2-microglobulin (sprot)

A beta-2-microglobulin that is encoded in the genome of human.


INDOLE-3-BUTYRIC ACID

A indol-3-yl carboxylic acid that is butanoic acid carrying a 1H-indol-3-yl substituent at position 1.


N-palmitoylethanolamine

An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.


A 26-hydroxycholesterol in which the 25-position has R-configuration.


L-glutamic 5-semialdehyde

A glutamic semialdehyde arising from formal reduction of the side-chain carboxy group of L-glutamic acid.


PHTHALIC ACID

A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.


name: PTH2_HUMAN Peptidyl-tRNA hydrolase 2, mitochondrial (sprot)

description: A peptidyl-tRNA hydrolase 2, mitochondrial that is encoded in the genome of human.


name: AOAH_HUMAN Acyloxyacyl hydrolase (sprot)

description: An acyloxyacyl hydrolase that is encoded in the genome of human.


HYEP_HUMAN Epoxide hydrolase 1 (sprot)

An epoxide hydrolase 1 that is encoded in the genome of human.


name: RPE65_HUMAN Retinoid isomerohydrolase (sprot)

description: A retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of human.


name: MOC2B_HUMAN Molybdopterin synthase catalytic subunit (sprot)

description: A molybdopterin synthase catalytic subunit that is encoded in the genome of human.


name: CN37_HUMAN 2',3'-cyclic-nucleotide 3'-phosphodiesterase (sprot)

description: A 2',3'-cyclic-nucleotide 3'-phosphodiesterase that is encoded in the genome of human.


name: CYLD_HUMAN Ubiquitin carboxyl-terminal hydrolase CYLD (sprot)

description: A ubiquitin carboxyl-terminal hydrolase CYLD that is encoded in the genome of human.


name: PRDX5_HUMAN Peroxiredoxin-5, mitochondrial (sprot)

description: A peroxiredoxin-5, mitochondrial that is encoded in the genome of human.


AQP3_HUMAN Aquaporin-3 (sprot)

An aquaporin-3 that is encoded in the genome of human.


name: PTH_HUMAN Peptidyl-tRNA hydrolase (sprot)

description: A probable peptidyl-tRNA hydrolase PTRH1 that is encoded in the genome of human.


AQP2_HUMAN Aquaporin-2 (sprot)

An aquaporin-2 that is encoded in the genome of human.


PRDX1_HUMAN Peroxiredoxin-1 (sprot)

A peroxiredoxin-1 that is encoded in the genome of human.


name: PRDX3_HUMAN Thioredoxin-dependent peroxide reductase, mitochondrial (sprot)

description: A thioredoxin-dependent peroxide reductase, mitochondrial that is encoded in the genome of human.


PRDX4_HUMAN Peroxiredoxin-4 (sprot)

A peroxiredoxin-4 that is encoded in the genome of human.


name: UBP16_HUMAN Ubiquitin carboxyl-terminal hydrolase 16 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 16 that is encoded in the genome of human.


name: STABP_HUMAN STAM-binding protein (sprot)

description: A STAM-binding protein that is encoded in the genome of human.


name: UBP51_HUMAN Ubiquitin carboxyl-terminal hydrolase 51 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 51 that is encoded in the genome of human.


name: UBP33_HUMAN Ubiquitin carboxyl-terminal hydrolase 33 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 33 that is encoded in the genome of human.


name: UBP22_HUMAN Ubiquitin carboxyl-terminal hydrolase 22 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 22 that is encoded in the genome of human.


name: UBP47_HUMAN Ubiquitin carboxyl-terminal hydrolase 47 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 47 that is encoded in the genome of human.


name: UBP40_HUMAN Ubiquitin carboxyl-terminal hydrolase 40 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 40 that is encoded in the genome of human.


name: UBP35_HUMAN Ubiquitin carboxyl-terminal hydrolase 35 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 35 that is encoded in the genome of human.


name: UBP36_HUMAN Ubiquitin carboxyl-terminal hydrolase 36 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 36 that is encoded in the genome of human.


name: UBP29_HUMAN Ubiquitin carboxyl-terminal hydrolase 29 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 29 that is encoded in the genome of human.


name: UBP46_HUMAN Ubiquitin carboxyl-terminal hydrolase 46 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 46 that is encoded in the genome of human.


name: Q08AK7_HUMAN Ubiquitin carboxyl-terminal hydrolase (trembl)


name: UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 1 that is encoded in the genome of human.


name: UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 7 that is encoded in the genome of human.


name: UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 5 that is encoded in the genome of human.


name: USP9X_HUMAN Ubiquitin carboxyl-terminal hydrolase 9X (sprot)

description: A probable ubiquitin carboxyl-terminal hydrolase FAF-X that is encoded in the genome of human.


name: USP9Y_HUMAN Ubiquitin carboxyl-terminal hydrolase 9Y (sprot)

description: A probable ubiquitin carboxyl-terminal hydrolase FAF-Y that is encoded in the genome of human.


name: UBP26_HUMAN Ubiquitin carboxyl-terminal hydrolase 26 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 26 that is encoded in the genome of human.


name: UBP42_HUMAN Ubiquitin carboxyl-terminal hydrolase 42 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 42 that is encoded in the genome of human.


name: UBP32_HUMAN Ubiquitin carboxyl-terminal hydrolase 32 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 32 that is encoded in the genome of human.


name: UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 30 that is encoded in the genome of human.


name: UBP13_HUMAN Ubiquitin carboxyl-terminal hydrolase 13 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 13 that is encoded in the genome of human.


name: A6NJA2_HUMAN Ubiquitin carboxyl-terminal hydrolase (trembl)


name: UBP6_HUMAN Ubiquitin carboxyl-terminal hydrolase 6 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 6 that is encoded in the genome of human.


name: UBP10_HUMAN Ubiquitin carboxyl-terminal hydrolase 10 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 10 that is encoded in the genome of human.


name: UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 8 that is encoded in the genome of human.


name: UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 15 that is encoded in the genome of human.


name: UBP3_HUMAN Ubiquitin carboxyl-terminal hydrolase 3 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 3 that is encoded in the genome of human.


AQP1_HUMAN Aquaporin-1 (sprot)

An aquaporin-1 that is encoded in the genome of human.


AQP4_HUMAN Aquaporin-4 (sprot)

An aquaporin-4 that is encoded in the genome of human.


AQP10_HUMAN Aquaporin-10 (sprot)

An aquaporin-10 that is encoded in the genome of human.


name: UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 11 that is encoded in the genome of human.


name: UBP38_HUMAN Ubiquitin carboxyl-terminal hydrolase 38 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 38 that is encoded in the genome of human.


name: UBP21_HUMAN Ubiquitin carboxyl-terminal hydrolase 21 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 21 that is encoded in the genome of human.


name: UBP37_HUMAN Ubiquitin carboxyl-terminal hydrolase 37 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 37 that is encoded in the genome of human.


name: UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase 2 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 2 that is encoded in the genome of human.


name: UBP28_HUMAN Ubiquitin carboxyl-terminal hydrolase 28 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 28 that is encoded in the genome of human.


name: UBP20_HUMAN Ubiquitin carboxyl-terminal hydrolase 20 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 20 that is encoded in the genome of human.


name: UBP25_HUMAN Ubiquitin carboxyl-terminal hydrolase 25 (sprot)

description: A ubiquitin carboxyl-terminal hydrolase 25 that is encoded in the genome of human.


name: HACD1_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (sprot)

description: A very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 that is encoded in the genome of human.


name: HACD2_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (sprot)

description: A very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 that is encoded in the genome of human.


name: HACD4_HUMAN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (sprot)

description: A very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 that is encoded in the genome of human.


name: HPSE2_HUMAN Inactive heparanase-2 (sprot)

description: A heparanase-2 that is encoded in the genome of human.


name: HTD2_HUMAN Hydroxyacyl-thioester dehydratase type 2, mitochondrial (sprot)

description: A hydroxyacyl-thioester dehydratase type 2, mitochondrial that is encoded in the genome of human.


name: ICT1_HUMAN Large ribosomal subunit protein mL62 (sprot)

description: An immature colon carcinoma transcript 1 protein that is encoded in the genome of human.


name: PTRD1_HUMAN Putative peptidyl-tRNA hydrolase PTRHD1 (sprot)

description: A putative peptidyl-tRNA hydrolase PTRHD1 that is encoded in the genome of human.


WATER

An oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms


oleamide

A fatty amide derived from oleic acid.


1,3,7-trimethyluric acid

An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8, and the nitrogens at positions 1, 3, and 7 are substituted by methyl groups. It is a metabolite of caffeine.


apigenin

A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7.  It induces autophagy in leukaemia cells.


aminoacetone

A propanone consisting of acetone having an amino group at the 1-position.


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of trans-dec-3-enoic acid.


dimethyl sulfoxide

A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.


A retinal having 2E,4Z,6E,8E-double bond geometry.


Imerslund-Grasbeck syndrome type 1

description: An autosomal recessive disorder characterized by onset of megaloblastic anemia associated with decreased serum vitamin B12 (cobalamin, Cbl) in infancy or early childhood. Low molecular weight (LMW) proteinuria is frequently present, but sometimes occurs later and is usually mild or subclinical. Patients often present with vague symptoms, including failure to thrive, loss of appetite, fatigue, lethargy, and/or recurrent infections. Some patients may present later in childhood with neurologic abnormalities related to B12 deficiency, such as sensorimotor neuropathy and/or cognitive disturbances.


CD320_HUMAN CD320 antigen (sprot)

A CD320 molecule that is encoded in the genome of human.


cob(III)alamin

A cobalamin in which the central cobalt atom has an oxidation state of +3.


2-methylbutyric acid

A methylbutyric acid comprising a butyric acid core carrying a 2-methyl substituent. Produced from amino acid leucine during nutrient starvation in bacteria.


A cholestanoyl-CoA formed by thioester linkage between 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid and coenzyme A.


phenylephrine

A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.


docosahexaenoic acid

A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.


name: ECH1_HUMAN Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (sprot)

description: A Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial that is encoded in the genome of human.


name: ECI1_HUMAN Enoyl-CoA delta isomerase 1, mitochondrial (sprot)

description: An enoyl-CoA Delta isomerase 1, mitochondrial that is encoded in the genome of human.


(Z)-hexadec-7-enoic acid

A C16 fatty acid having a (Z)-double bond at the 7-position; marker of early life stage mortality in trout and of physiologically active autotrophic bacteria in complex microbial communities.


5,6-epoxyeicosatrienoic acid

An EET obtained by formal epoxidation of the 5,6-double bond of arachidonic acid.


A bismuth cation having a net electric charge of +3.


HYDROXYPHENYL PROPIONIC ACID

A hydroxy monocarboxylic acid consisting of propionic acid having a 4-hydroxyphenyl group at the 3-position.


DPEP2_HUMAN Dipeptidase 2 (sprot)

A dipeptidase 2 that is encoded in the genome of human.


LEUKOTRIEN E4

A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and an L-cystein-S-yl group at position 6 (6R).


ARACHIDIC ACID

A C20 striaght-chain saturated fatty acid which forms a minor constituent of peanut (L. arachis) and corn oils. Used as an organic thin film in the production of liquid crystals for a wide variety of technical applications.


A 6,7-dihydrobiopterin that has R configuration at position 6 and in which the 1,2-dihydroxypropyl substituent has 1R,2S configuration.


(S)-methylmalonaldehydic acid

A 2-methyl-3-oxopropanoic acid that has S-configuration.


The all-cis-isomer of a C22 polyunsaturated fatty acid having four double bonds in the 7-, 10-, 13- and 16-positions. One of the most abundant fatty acids in the early human brain.


(11Z)-icos-11-enoic acid

An icosenoic acid having a cis- double bond at position 11.


An EET obtained by formal epoxidation of the 8,9-double bond of arachidonic acid.


4-hydroxy-1-pyrroline-2-carboxylic acid

A 1-pyrrolinecarboxylic acid having a hydroxy substituent at the 4-position.


2-PICOLINIC ACID

A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.


O-lauroyl-L-carnitine

An O-acyl-L-carnitine in which the acyl group is specified as lauroyl (dodecanoyl).


benzoyl-CoA

The simplest member of the class of  benzoyl-CoAs that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of benzoic acid.


HEPTADECANOIC ACID

A C17 saturated fatty acid and trace component of fats in ruminants.


2-hydroxymyristic acid

A  long-chain fatty acid that is a derivative of myristic acid having a hydroxy substituent at C-2.


A DHET obtained by formal dihydroxylation across the 14,15-double bond of arachidonic acid.


curcumin

A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.


dihydrourocanic acid

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 3 has been replaced by an imidazol-4-yl group.


A neopterin where positions C-7 and C-8 have been hydrogenated.


A 4a-hydroxytetrahydrobiopterin which has R configuration at position 6 and in which the dihydroxypropyl substituent has L-erythro configuration.


N-acetylcadaverine

An N-substituted cadaverine that is cadaverine in which one of the amino groups has been converted to the corresponding acetamide.


GET3_HUMAN ATPase GET3 (sprot)

An ATPase GET3 that is encoded in the genome of human.


(R)-3-aminoisobutyric acid

The (R)-enantiomer of 3-aminoisobutyric acid.


indole-3-propionic acid

An  indol-3-yl carboxylic acid that is  propionic acid substituted by a 1H-indol-3-yl group at position 3.


METHYLSULFANYLMETHANE

A methyl sulfide in which the sulfur atom is substituted by two methyl groups. It is produced naturally by some marine algae.


hydrochloric acid

A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.


acryloyl-CoA

The S-acryloyl derivative of coenzyme A.


A DHET obtained by formal dihydroxylation across the 8,9-double bond of arachidonic acid.


A DHET obtained by formal dihydroxylation across the 11,12-double bond of arachidonic acid.


3-(imidazol-1-yl)lactic acid

An imidazolyl carboxylic acid that is lactic acid in which one of the methyl hydrogens is substituted by an imidazol-1-yl group.


cadaverine

An alkane-alpha,omega-diamine comprising a straight-chain pentane core with amino substitutents at positions 1 and 5. A colourless syrupy liquid diamine with a distinctive unpleasant odour, it is a homologue of putresceine and is formed by the bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. It is also found in plants such as soyabean.


coumestrol

A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.


tridecanedioic acid

An alpha,omega-dicarboxylic acid that is undecane substituted by carboxylic acid groups at positions C-1 and C-11.


OXALIC ACID

An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.


biochanin A

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.


A DHET obtained by formal dihydroxylation across the 5,6-double bond of arachidonic acid.


CETOSTEARYL ALCOHOL

A long-chain primary fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of 18 carbon atoms.


hawkinsin

A cysteine derivative that is cysteine in which the thiol group is substituted by a [2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]sulfanediyl group. Hawkinsinuria is an inherited disorder which is characterized by the inability to break down the amino acid tyrosine. This results in the finding of certain metabolites in the urine, such as hawkinsin.


HEXACOSANOIC ACID

A 26-carbon, straight-chain, saturated fatty acid.


oleanolic acid

A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.


O-tiglyl-L-carnitine

An O-acyl-L-carnitine compound having trans-2-methyl-2-butenoyl (tiglyl) as the acyl substituent.


NERVONIC ACID

A tetracosenoic acid having a cis-double bond at position 15.


alitretinoin

A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.


ISOFUCOSTEROL

A 3beta-sterol consisting of stigmastan-3beta-ol with double bonds at positions 5 and 24(28). The double bond at postion 24(28) adopts a Z-configuration.


name: S4A11_HUMAN Solute carrier family 4 member 11 (sprot)

description: A solute carrier family 4 member 11 that is encoded in the genome of human.


name: AKAP9_HUMAN A-kinase anchor protein 9 (sprot)

description: An A-kinase anchor protein 9 that is encoded in the genome of human.


NMDA

An aspartic acid derivative having an N-methyl substituent and D-configuration.


URSOLIC ACID

A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.


SUMIKI'S ACID

A member of the class of furoic acids that is 2-furoic acid substituted at position 5 by a hydroxymethyl group.


hydroquinone

A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.


4-deoxythreonic acid

The (2S,3R)-stereoisomer of 2,3-dihydroxybutanoic acid.


A nickel cation in which the nickel carries a double positive charge.


3-HYDROXYBENZOIC ACID

A monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3. It has been isolated from Taxus baccata. It is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc.


3-deoxychenodeoxycholic acid

A monohydroxy-5beta-cholanic acid in which the hydroxy group is located at the 7alpha-position. A structural derivative of the bile acid, chenodeoxycholic acid.


sulfoglycochenodeoxycholic acid

A steroid sulfate that is the 3-O-sulfo derivative of glycochenodeoxycholic acid.


GLYCERYLPHOSPHATE

A glycerol monophosphate having the phosphate group at the 2-position.


taurolithocholic acid sulfate

The steroid sulfate of taurolithocholic acid.


sulfoglycolithocholic acid

The 3-O-sulfo derivative of glycolithocholic acid.


A dihydroxy monocarboxylic acid that is 3-hydroxypropanoic acid substituted by a 3-hydroxyphenyl group at position 3.


ISORHAMNETIN

A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.


6-hydroxynicotinic acid

A monohydroxypyridine that is the 6-hydroxy derivative of nicotinic acid.


thiamine monophosphate

A thiamine phosphate that is thiamin(1+) in which the hydroxy group is replaced by a phosphate group.


NARINGENIN

The (S)-enantiomer of naringenin.


CANAVANINE

L-Canavanine in zwitterionic form.


CYANIDIN

An anthocyanidin cation that is flavylium substituted at positions 3, 3', 4', 5 and 7 by hydroxy groups.


A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).


An anhydro sugar of D-glucitol.


METHANE

A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).


desmosterol

A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.


nandrolone

A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.


myricetin

A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 3', 4', 5, 5' and 7. It has been isolated from the leaves of Myrica rubra and other plants.


cysteic acid

An amino sulfonic acid that is the sulfonic acid analogue of cysteine.


androsterone sulfate

A steroid sulfate that is the 3-sulfate of androsterone.


13,14-dihydro-15-oxo-prostaglandin E2

The 13,14-dihydro derivative of 15-oxo-prostaglandin E2.


catechin

The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.


name: DHRS2_HUMAN Dehydrogenase/reductase SDR family member 2, mitochondrial (sprot)

description: A dehydrogenase/reductase SDR family member 2, mitochondrial that is encoded in the genome of human.


cortisone

A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.


oleoyl-lysophosphatidylcholine

An oleoyl-sn-glycero-3-phosphocholine in which the acyl group at position 1 is (9Z)-octadecenoyl (oleoyl) and the hydroxy group at position 2 is unsubstituted.


1-methyl-4-imidazoleacetic acid

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1-methyl-1H-imidazol-4-yl group.


(13Z,16Z,19Z)-docosatrienoic acid

A long-chain omega-3 fatty acid that is docosanoic acid having three double bonds located at positions 13, 16 and 19 (the (13Z,16Z,19Z-geoisomer).


theobromine

A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.


androsterone 3-glucosiduronic acid

A steroid glucosiduronic acid having androsterone as the steroid component.


testosterone sulfate

A steroid sulfate that is testosterone substituted by a sulfoxy group at position 17.


name: CCL2_HUMAN C-C motif chemokine 2 (sprot)

description: A C-C motif chemokine 2 that is encoded in the genome of human.


name: NALDL_HUMAN Aminopeptidase NAALADL1 (sprot)

description: An aminopeptidase NAALADL1 that is encoded in the genome of human.


hexanoyl-CoA

A medium-chain fatty acyl-CoA having hexanoyl as the S-acyl group.


name: NEU1_HUMAN Oxytocin-neurophysin 1 (sprot)

description: An oxytocin-neurophysin 1 that is encoded in the genome of human.


PPCE_HUMAN Prolyl endopeptidase (sprot)

A prolyl endopeptidase that is encoded in the genome of human.


name: MAFF_HUMAN Transcription factor MafF (sprot)

description: A transcription factor MafF that is encoded in the genome of human.


name: A0T1J2_HUMAN Oxytocin receptor (Fragment) (trembl)


nitrate

A nitrogen oxoanion formed by loss of a proton from nitric acid. Principal species present at pH 7.3.


6-oxoprostaglandin F1alpha

A prostaglandin Falpha that is prostaglandin F1alpha bearing a keto substituent at the 6-position.


name: Q59FP7_HUMAN DNA (cytosine-5)-methyltransferase 1 (Fragment) (trembl)


A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.


ellagic acid

An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.


A tocopherol in which the chroman-6-ol core is substituted by a methyl group at position 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.


A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.


xylitol

A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group.


diroleuton

An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.


N-acetyl-L-serine

An N-acetyl-L-amino acid in which the amino acid specified is L-serine. Metabolite observed in cancer metabolism.


dihydrotestosterone

A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.


1D-myo-inositol 6-phosphate

A myo-inositol monophosphate in which the phosphate group is located at position 6.


SMS_HUMAN Somatostatin (sprot)

A somatostatin that is encoded in the genome of human.


mercaptamine

An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.


The meso-diastereomer of butane-1,2,3,4-tetrol.


lycopene

An acyclic carotene commonly obtained from tomatoes and other red fruits.


ANILINE

A primary arylamine in which an amino functional group is substituted for one of the benzene hydrogens.


ergothioneine

A L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine synthesized by bacteria and fungi with antioxidant properties. It is found ubiquitously in plants and animals and is present in many human foodstuffs.


SHIKIMIC ACID

A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.


QUINIC ACID

The (-)-enantiomer of quinic acid.


γ-linolenic acid

A C18, omega-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.


DELPHINIDIN

An anthocyanidin cation consisting of benzopyrylium with hydroxy substituents at the 3-, 5- and 7-positions and a 3,4,5-trihydroxyphenyl group at the 2-position. It is a plant pigment responsible for the colours of the plants of the genera Viola and Delphinium.


LEUKOTRIENE D4

A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).


1-methyluric acid

An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine.


benzyl alcohol

An aromatic alcohol that consists of benzene bearing a single hydroxymethyl substituent.


name: NOXO1_HUMAN NADPH oxidase organizer 1 (sprot)

description: An NADPH oxidase organizer 1 that is encoded in the genome of human.


hydrogen peroxide

An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.


A retinoid that is retinoic acid in which the carboxy proton has been replaced by a beta-D-glucuronyl residue.


nicotinyl methylamide

A pyridinecarboxamide that is nicotinamide in which one of the amide hydrogens is substituted by a methyl group.


A butanediol in which hydroxylation is at C-2 and C-3.


PETUNIDIN

An anthocyanidin cation that is flavylium bearing five hydroxy substituents at positions 3, 3', 4', 5 and 7 as well as a methoxy substituent at position 5'.


Prednisone Action Pathway,Drug Action

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: Prednisone Metabolism Pathway,Drug Metabolism


CYB_HUMAN Cytochrome b (sprot)

A cytochrome b that is encoded in the genome of human.


name: HBG1_HUMAN Hemoglobin subunit gamma-1 (sprot)

description: A hemoglobin subunit gamma-1 that is encoded in the genome of human.


name: C56D2_HUMAN Transmembrane reductase CYB561D2 (sprot)

description: A transmembrane reductase CYB561D2 that is encoded in the genome of human.


name: CY561_HUMAN Transmembrane ascorbate-dependent reductase CYB561 (sprot)

description: A eukaryotic cytochrome b561 that is encoded in the genome of human.


name: CCHL_HUMAN Holocytochrome c-type synthase (sprot)

description: A holocytochrome c-type synthase that is encoded in the genome of human.


name: CP26A_HUMAN Cytochrome P450 26A1 (sprot)

description: A cytochrome P450 26A1 that is encoded in the genome of human.


name: FLVC1_HUMAN Heme transporter FLVCR1 (sprot)

description: A heme transporter FLVCR1 that is encoded in the genome of human.


name: HRG_HUMAN Histidine-rich glycoprotein (sprot)

description: A histidine-rich glycoprotein that is encoded in the genome of human.


CYB5_HUMAN Cytochrome b5 (sprot)

A cytochrome b5 that is encoded in the genome of human.


name: ABCB6_HUMAN ATP-binding cassette sub-family B member 6 (sprot)

description: An ATP-binding cassette sub-family B member 6 that is encoded in the genome of human.


name: ABCBA_HUMAN ATP-binding cassette sub-family B member 10, mitochondrial (sprot)

description: An ATP-binding cassette sub-family B member 10, mitochondrial that is encoded in the genome of human.


name: C27C1_HUMAN Cytochrome P450 27C1 (sprot)

description: A cytochrome P450 27C1 that is encoded in the genome of human.


name: C56D1_HUMAN Probable transmembrane reductase CYB561D1 (sprot)

description: A probable transmembrane reductase CYB561D1 that is encoded in the genome of human.


name: CB5D1_HUMAN Cytochrome b5 domain-containing protein 1 (sprot)

description: A cytochrome b5 domain-containing protein 1 that is encoded in the genome of human.


NEUFC_HUMAN Neuferricin (sprot)

A neuferricin that is encoded in the genome of human.


name: CDC37_HUMAN Hsp90 co-chaperone Cdc37 (sprot)

description: An Hsp90 co-chaperone Cdc37 that is encoded in the genome of human.


name: CP26B_HUMAN Cytochrome P450 26B1 (sprot)

description: A cytochrome P450 26B1 that is encoded in the genome of human.


name: CP26C_HUMAN Cytochrome P450 26C1 (sprot)

description: A cytochrome P450 26C1 that is encoded in the genome of human.


CP2W1_HUMAN Cytochrome P450 2W1 (sprot)

A cytochrome P450 2W1 that is encoded in the genome of human.


CP4V2_HUMAN Cytochrome P450 4V2 (sprot)

A cytochrome P450 4V2 that is encoded in the genome of human.


name: FS2P1_HUMAN Putative fatty acid desaturase 2-like protein FADS2B (sprot)


name: FADS3_HUMAN Fatty acid desaturase 3 (sprot)

description: A fatty acid desaturase 3 that is encoded in the genome of human.


name: FRRS1_HUMAN Ferric-chelate reductase 1 (sprot)

description: A ferric-chelate reductase 1 that is encoded in the genome of human.


name: HBAT_HUMAN Hemoglobin subunit theta-1 (sprot)

description: A hemoglobin subunit theta-1 that is encoded in the genome of human.


name: HBAZ_HUMAN Hemoglobin subunit zeta (sprot)

description: A hemoglobin subunit zeta that is encoded in the genome of human.


name: HBE_HUMAN Hemoglobin subunit epsilon (sprot)

description: A hemoglobin subunit epsilon that is encoded in the genome of human.


HBM_HUMAN Hemoglobin subunit mu (sprot)

A hemoglobin subunit mu that is encoded in the genome of human.


name: HEBP1_HUMAN Heme-binding protein 1 (sprot)

description: A heme-binding protein 1 that is encoded in the genome of human.


name: HEBP2_HUMAN Heme-binding protein 2 (sprot)

description: A heme-binding protein 2 that is encoded in the genome of human.


name: HRG1_HUMAN Heme transporter HRG1 (sprot)

description: A heme transporter HRG1 that is encoded in the genome of human.


name: NF2L1_HUMAN Endoplasmic reticulum membrane sensor NFE2L1 (sprot)

description: An endoplasmic reticulum membrane sensor NFE2L1 that is encoded in the genome of human.


heme

A heme is any tetrapyrrolic chelate of iron.


neutrophil actin dysfunction

description: Solitary or multiple, slightly raised, pigmented lesions with irregular borders, usually measuring more than 0.6cm in greatest dimension. Morphologically, there is melanocytic atypia and the differential diagnosis from melanoma may be difficult. Patients are at an increased risk for the development of melanoma.


orazamide

An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.


testosterone 17-glucosiduronic acid

A steroid glucosiduronic that is testosterone carrying a glucosiduronic acid residue at position 17.


thromboxane

A class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels.


RAFFINOSE

A trisaccharide composed of alpha-D-galactopyranose, alpha-D-glucopyranose and beta-D-fructofuranose joined in sequence by 1->6 and 1<->2 glycosidic linkages, respectively.


genistein

A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.


palmitoleic acid

A hexadec-9-enoic acid in which the double bond at position C-9 has cis configuration.


trans-vaccenic acid

The trans- isomer of vaccenic acid.


acetoin

A methyl ketone that is butan-2-one substituted by a hydroxy group at position 3.


rutoside

A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.


THROMBOXANE B2

A member of the class of thromboxanes B that is (5Z,13E)-thromboxa-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15.


A 17alpha-hydroxy-C21-steroid that is cortisol in which the 4-5 double bond has undergone formal hydrogenation to give the corresponding 5beta- steroid.


PELARGONIDIN

An anthocyanidin cation that is flavylium substituted by a hydroxy groups at positions 3, 5, 7 and 4'.


NICOTINURIC ACID

An N-acylglycine having nicotinoyl as the acyl substituent.


osteoarthritis susceptibility 1

description: Any osteoarthritis in which the cause of the disease is a mutation in the FRZB gene.


HYDROGEN SULFIDE

A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.


name: SELT_HUMAN Thioredoxin reductase-like selenoprotein T (sprot)

description: A thioredoxin reductase-like selenoprotein T that is encoded in the genome of human.


SELENOCYSTEINE

The L-enantiomer of selenocysteine.


D-gulonic acid

A gulonic acid having D-configuration.


phloretin

A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.


daidzein

A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'.


CYCLOHEXANONE

A cyclic ketone that consists of cyclohexane bearing a single oxo substituent.


indole-3-carboxylic acid

An indole-3-carboxylic acid carrying a carboxy group at position 3.


cervical cancer

description: A primary or metastatic malignant neoplasm involving the cervix.


A methyladenosine carrying a methyl substituent at position 1.


SDMA

A  L-arginine derivative having two methyl groups at the N(omega)- and N'(omega)-positions


D-glutamic acid

An optically active form of glutamic acid having D-configuration.


glycolaldehyde

The glycolaldehyde derived from ethylene glycol. The parent of the class of glycolaldehydes.


alpha-D-glucose

D-Glucopyranose having alpha-configuration at the anomeric centre.


(S)-dihydroorotic acid

The (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine.


GDP-alpha-D-glucose

A GDP-D-glucose having alpha-configuration at the anomeric centre.


name: TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 (sprot)

description: A transient receptor potential cation channel TRPA1 that is encoded in the genome of human.


(-)-menthol

A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer.


5-AMINOVALERIC ACID

A delta-amino acid comprising pentanoic acid with an amino substituent at C-5; a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist.


name: DDB2_HUMAN DNA damage-binding protein 2 (sprot)

description: A DNA damage-binding protein 2 that is encoded in the genome of human.


name: DDB1_HUMAN DNA damage-binding protein 1 (sprot)

description: A DNA damage-binding protein 1 that is encoded in the genome of human.


name: PUF60_HUMAN Poly(U)-binding-splicing factor PUF60 (sprot)

description: A poly(U)-binding-splicing factor PUF60 that is encoded in the genome of human.


PYRIMIDINE

The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.


name: Q2VT96_HUMAN chitinase (Fragment) (trembl)


name: A5D6V7_HUMAN chitinase (Fragment) (trembl)


name: Q5VUV5_HUMAN chitinase (Fragment) (trembl)


TRIACETYLCHITOTRIOSE

A linear amino trisaccharide consisting of three N-acetyl-beta-D-glucosamine residues linked (1->4).


alpha-D-galacturonic acid

The alpha-anomer of D-galacturonic acid.


benzoquinone

The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.


PROPIONALDEHYDE

An aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals.


D-ornithine

The D-enantiomer of ornithine. It is an intermediate metabolite produced in the urea cycle.


D-LIMONENE

An optically active form of limonene having (4R)-configuration.


EDN1_HUMAN Endothelin-1 (sprot)

An endothelin-1 that is encoded in the genome of human.


name: DYL1_HUMAN Dynein light chain 1, cytoplasmic (sprot)

description: A dynein light chain 1, cytoplasmic that is encoded in the genome of human.


nitric oxide

A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.


2-phospho-D-glyceric acid

A 2-phosphoglyceric acid in which the glyceric acid moiety has D (R) configuration.


beta-D-galacturonic acid

A D-galactopyranuronic acid with a beta-configuration at the anomeric center.


D-lysine

The D-enantiomer of the alpha-amino acid lysine.


D-serine

The R-enantiomer of serine.


BUTANEDIONE

An alpha-diketone that is butane substituted by oxo groups at positions 2 and 3. It is a metabolite produced during the malolactic fermentation.


D-proline

The D-enantiomer of proline.


D-arginine

A D-alpha-amino acid that is the D-isomer of arginine.


D-glutamine

The D-enantiomer of glutamine.


cetyl alcohol

A long-chain primary fatty alcohol that is hexadecane substituted by a hydroxy group at position 1.


cob(I)alamin

A cobalamin in which the central cobalt atom has an oxidation state of +1.


HISTIDINOL

An amino alcohol that is propanol substituted by 1H-imidazol-4-yl group at position 3 and an amino group at position 2 (the 2S stereoisomer).


name: Q53H18_HUMAN Beta-galactosidase (Fragment) (trembl)


name: Q53G40_HUMAN Beta-galactosidase (Fragment) (trembl)


b-D-GALACTOSE

A D-galactopyranose having beta configuration at the anomeric centre.


4-guanidinobutanoic acid

The 4-guanidino derivative of butanoic acid.


The furanose form of gulonolactone having L-configuration.


A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.


beta-D-glucose 6-phosphate

A D-glucopyranose 6-phosphate in which the anomeric centre has beta-configuration.


cis-caffeic acid

The cis-isomer of caffeic acid.


fytic acid

A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.


alpha-D-glucose 1,6-bisphosphate

A D-glucose 1,6-bisphosphate in which both phosphate groups are monophosphates.


(2R)-homocitric acid

The (R)-enantiomer of homocitric acid.


A cholestanoid that is 5beta-cholestan-26-al substituted by hydroxy groups at positions 3, 7 and 12 respectively.


A deoxyinosine phosphate compound having a diphosphate group at the 5'-position.


dITP

A deoxyinosine phosphate compound having a triphosphate group at the 5'-position.


An adenosine 3'-phosphate with a monophosphate group at the 3'-position.


BUTANAL

A member of the class of  butanals that consists of propane bearing a formyl substituent at the 1-position. The parent of the class of butanals.


calcifediol

A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.


stachyose

A tetrasaccharide consisting of sucrose having an alpha-D-galactosyl-(1->6)-alpha-D-galactosyl moiety attached at the 6-position of the glucose.


phytomenadione

A member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones.


lauroyl-CoA

A medium-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of lauric (dodecanoic) acid.


scopolamine

A tropane alkaloid that is the (S)-tropic acid ester of 6beta,7beta-epoxy-1alphaH,5alphaH-tropan-3alpha-ol.


pseudotumor cerebri

description: Idiopathic intracranial hypertension is a neurological disorder characterized by isolated increased intracranial pressure manifesting with recurrent and persistent headaches, nausea, vomiting, progressive and transient obstruction of the visual field, papilledema. Visual loss can be irreversible.


2-aminoacrylic acid

A 2,3-dehydroamino acid that is alanine which has been dehydrogenated to introduce a double bond between positions 2 and 3.


perillyl alcohol

A limonene monoterpenoid consists of a cyclohexene ring substituted by a hydroxymethyl  and a prop-1-en-2-yl group at positions 1 and 4 respectively. It is a constituent of a variety of essential oils including lavender.


MT1E_HUMAN Metallothionein-1E (sprot)

A metallothionein-1E that is encoded in the genome of human.


MT1F_HUMAN Metallothionein-1F (sprot)

A metallothionein-1F that is encoded in the genome of human.


MT1G_HUMAN Metallothionein-1G (sprot)

A metallothionein-1G that is encoded in the genome of human.


MT1H_HUMAN Metallothionein-1H (sprot)

A metallothionein-1H that is encoded in the genome of human.


MT1X_HUMAN Metallothionein-1X (sprot)

A metallothionein-1X that is encoded in the genome of human.


MT1L_HUMAN Metallothionein-1L (sprot)

A metallothionein-1L that is encoded in the genome of human.


MT1M_HUMAN Metallothionein-1M (sprot)

A metallothionein-1M that is encoded in the genome of human.


MT1A_HUMAN Metallothionein-1A (sprot)

A metallothionein-1A that is encoded in the genome of human.


MT1B_HUMAN Metallothionein-1B (sprot)

A metallothionein-1B that is encoded in the genome of human.


N-methylhydantoin

A imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin.


PERILLALDEHYDE

An aldehyde that is cyclohex-1-ene-1-carbaldehyde substituted by a prop-1-en-2-yl group at position 4.


vitamin A palmitate

An all-trans-retinyl ester obtained by formal condensation of the carboxy group of palmitic (hexadecanoic acid) with the hydroxy group of all-trans-retinol. It is used in cosmetic products to treat various skin disorders such as acne, skin aging, wrinkles, dark spots, and also protect against psoriasis.


trans-p-coumaryl alcohol

4-Hydroxycinnamyl alcohol with E-configuration of the propenyl double bond. It is one of the main monolignols.


N-methylputrescine

An N-monosubstituted putrescine where the N-substituent is methyl.


A 1-(5-phospho-D-ribosyl)-ATP in which the 5-phospho-D-ribosyl residue has beta-configuration at the anomeric centre.


A dialkyl ketone with methyl and pentyl as the alkyl groups.


4-acetamidobutanoic acid

An N-acyl-gamma-aminobutyric acid resulting from the monoacetylation of the nitrogen of GABA.


DIMEDAZOL

A dimethylbenzimidazole carrying methyl substituents at positions 5 and 6.


resveratrol

A resveratrol in which the double bond has E configuration.


A 1-O-acyl-sn-glycero-3-phosphocholine in which the acyl group is specified as capryl (decanoyl).


A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.


An androstane-3,17-dione with a 5beta-configuration.


A phenylacetaldehyde in which the 3 and 4 positions of the phenyl group are substituted by hydroxy groups.


androstenediol

A 3beta-hydroxy-Delta(5)-steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.


cholesteryl acetate

A cholesterol ester obtained by formal acylation of the hydroxy group of cholesterol by acetic acid.


The pteridine that is lumazine substituted with methyl groups at C-6 and -7 and with a 1-D-ribityl group on N-8.


A purine ribonucleoside 5'-tetraphosphate compound having 5'-xanthosyl residues at the P(1)- and P(4)-positions.


5-O-Phosphono-D-ribitol in which the hydroxy group at position 1 is substituted by the 6-amino group of 5,6-diaminopyrimidine-2,4(1H,3H)-dione.


A myo-inositol tetrakisphosphate having the four phosphate groups placed at the 3-, 4-, 5- and 6-positions.


Huntington disease

description: Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia.


The (S)-enantiomer of 13-HPODE


An optically active form of 15-HETE having 15(S)-configuration..


A 3beta-sterol having the structure of desmosterol with an extra double bond at C-7--C-8.


2-(1-hydroxyethyl)thiamine diphosphate

A thiamine phosphate having a 1-hydroxyethyl substituent at the 2-position on the thiazolium ring and an O-diphosphate moiety.


3-aminoisobutyric acid

A beta-amino-acid that is isobutyric acid in which one of the methyl hydrogens is substituted by an amino group.


pentosidine

An imidazopyridine having norleucine and ornithine residues attached via their side-chains at the 4- and 2-positions respectively.


A hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (S)-3-hydroxyhexanoyl-CoA.


An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of all-cis-icosa-8,11,14-trienoic acid.


An androstanoid that is  testosterone with an oxo group at position 19.


selenomethionine

The L-enantiomer of selenomethionine.


name: NAA80_HUMAN N-alpha-acetyltransferase 80 (sprot)

description: An N-alpha-acetyltransferase 80 that is encoded in the genome of human.


beta-D-fructofuranose 6-phosphate

A D-fructofuranose 6-phosphate with a beta-configuration at the anomeric position.


1-phospho-alpha-D-glucuronic acid

The 1-O-phospho derivative of alpha-D-glucuronic acid.


A hydroxypregnenolone that is pregnenolone which has been substituted by a hydroxy group at position 21.


A 11beta-hydroxy steroid that is  progesterone substituted by a beta-hydroxy group at position 11.


An oxysterol that is the 22R-hydroxy derivative of cholesterol.


L-allothreonine

The L-enantiomer of allothreonine.


A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.


3-sulfopyruvic acid

A carboxyalkanesulfonic acid comprising pyruvic acid with a sulfo group attached at the C-3 position.


A member of the class of glycolaldehydes that is 3,4-dihydroxymandelaldehyde in which the hydroxy group at position 4 is replaced by a methoxy group.


A dihydroxybenzaldehyde carrying hydroxy groups at positions 2 and 5.


leucodopachrome

Indoline substituted with hydroxy groups at C-5 and -6 and a carboxy group at C-2, and with S stereochemistry at C-2.


P_HUMAN P protein (sprot)

A P protein that is encoded in the genome of human.


A member of the class of  phenols that is  styrene carrying a hydroxy substituent at position 4.


5-hydroxyindole acetaldehyde

An aldehyde that is acetaldehyde substituted by a 5-hydroxyindol-3-yl group.


A hydroxykynurenamine where the hydroxy group is located at the 5-position.


Quinoline substituted by hydroxy groups at the 4- and 6-positions. It is the product of 5-hydroxytryptophan metabolism, via monoamine oxidase catalysed conversion of 5-hydroxykynurenamine.


name: ABHD4_HUMAN (Lyso)-N-acylphosphatidylethanolamine lipase (sprot)

description: A (lyso)-N-acylphosphatidylethanolamine lipase that is encoded in the genome of human.


name: CNR1_HUMAN Cannabinoid receptor 1 (sprot)

description: A cannabinoid receptor 1 that is encoded in the genome of human.


anandamide

An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.


A member of the class of  tryptamines  that is melatonin with a hydroxy group substituent at position 6.


A dioxo monocarboxylic acid that is benzene in which the hydrogens at position 1, 2 and 3 are replaced by 3-carboxy-3-oxopropanoyl, amino and hydroxy groups, respectively. It is a by-product of tryptophan metabolism.


A non-proteinogenic alpha-amino acid that is 5-hydroxykynurenine bearing an N-formyl substituent.


N-formylanthranilic acid

An amidobenzoic acid consisting of anthranilic acid carrying an N-formyl group.


A member of the class of tryptamines that is the methyl ether derivative of serotonin.


5-methoxyindole-3-acetic acid

A member of the class of indole-3-acetic acids in which the hydrogen at position 5 of indole-3-acetic acid has been replaced by a methoxy group.


beta-aminopropionitrile

An aminopropionitrile carrying an amino group at the beta-position.


adenylyl selenate

The 5'-selenonooxyphosphate ester of adenosine.


METHYLSELENOCYSTEINE

An L-alpha-amino acid compound having methylselanylmethyl as the side-chain.


L-selenohomocysteine

A selenoamino acid that is the selenium analogue of L-homocysteine.


D-threitol

The D-enantiomer of threitol.


A pyridone that is 2-pyridone substituted with a carboxamide group at C-5 and a methyl group at N-1.


A member of the class of 4-pyridones that is 4-pyridone substituted with a carboxamide group at C-3 and a methyl group at N-1.


GLUTAURINE

A dipeptide resulting from the formal condensation of the amino group of taurine with the gamma-carboxy group of L-glutamic acid. It was initially found in the parathyroid in 1980 and later in the brain of mammals.


Glu-Lys

A dipeptide composed of L-glutamic acid and L-lysine joined by a peptide linkage.


PICEATANNOL

A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.


dexpanthenol

A monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen.


12-dehydro-leukotriene B4

A long-chain fatty acid consisting of leukotriene B4 having a 12-keto group in place of the 12-hydroxy group.


A member of the class of prostaglandins J that is prosta-5,9,12-trien-1-oic acid carrying oxo and hydsroxy substituents at positions 11 and 15 respectively (the 5Z,12E,15S-stereoisomer).


15-oxoprostaglandin F2alpha

A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group of prostaglandin F2alpha.


6-oxoprostaglandin E1

A prostaglandin E that is prostaglandin E1 bearing a keto substituent at the 6-position.


The (S)-enantiomer of 12-HPETE.


The (S)-enantiomer of 15-HPETE.


name: FA12_HUMAN Coagulation factor XII (sprot)

description: A coagulation factor XII that is encoded in the genome of human.


KNG1_HUMAN Kininogen-1 (sprot)

A kininogen-1 that is encoded in the genome of human.


KLKB1_HUMAN Plasma kallikrein (sprot)

A plasma kallikrein that is encoded in the genome of human.


name: ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 (sprot)

description: An endoplasmic reticulum aminopeptidase 1 that is encoded in the genome of human.


name: NEUL_HUMAN Neurolysin, mitochondrial (sprot)

description: A neurolysin, mitochondrial that is encoded in the genome of human.


name: BKRB1_HUMAN B1 bradykinin receptor (sprot)

description: A B1 bradykinin receptor that is encoded in the genome of human.


name: Q71U72_HUMAN Bradykinin B1 receptor (Fragment) (trembl)


name: Q13833_HUMAN B2 bradykinin receptor basal promoter, allele BP-58-T (Fragment) (trembl)


name: Q13832_HUMAN B2 bradykinin receptor basal promoter, allele BP-58-C (Fragment) (trembl)


name: Q68DM8_HUMAN B2 bradykinin receptor (trembl)


BRADYKININ

A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.


name: PLCX2_HUMAN PI-PLC X domain-containing protein 2 (sprot)

description: A PI-PLC X domain-containing protein 2 that is encoded in the genome of human.


name: PITC1_HUMAN Cytoplasmic phosphatidylinositol transfer protein 1 (sprot)

description: A cytoplasmic phosphatidylinositol transfer protein 1 that is encoded in the genome of human.


name: PLCX1_HUMAN PI-PLC X domain-containing protein 1 (sprot)

description: A PI-PLC X domain-containing protein 1 that is encoded in the genome of human.


name: PLCX3_HUMAN PI-PLC X domain-containing protein 3 (sprot)

description: A PI-PLC X domain-containing protein 3 that is encoded in the genome of human.


name: ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (sprot)

description: An Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 that is encoded in the genome of human.


The pteridine that is lumazine substituted with a methyl group at C-6, a hydroxy group at C-7 and a 1-D-ribityl group at N-8.


icosanoyl-CoA

A very long-chain fatty acyl-CoA that is the S-icosanoyl derivative of coenzyme A.


An EET obtained by formal epoxidation of the 14,15-double bond of arachidonic acid.


TYROSOL

A phenol substituted at position 4 by a 2-hydroxyethyl group.


FARNESOL

The (2-trans,6-trans)-stereoisomer of  farnesol.


(-)-LIMONENE

An optically active form of limonene having (4S)-configuration.


BUTYL ALCOHOL

A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.


The E (trans) stereoisomer of 4-hydroxynon-2-enal; it is the primary alpha,beta-unsaturated hydroxyalkenal produced by lipid peroxidation in cells.


N-methylserotonin

A member of the class of tryptamines that is serotonin in which one of the hydrogens attached to the primary amino group is replaced by a methyl group.


A steroid glucosiduronic acid that is 2-methoxyestrone having a single beta-D-glucuronic acid residue attached at position 3.


estrone 3-O-(beta-D-glucuronide)

The 3-beta-D-glucuronide of estrone.


geranylgeranyl diphosphate

The all-trans-isomer of geranylgeranyl diphosphate.


A myo-inositol tetrakisphosphate having the four phosphate groups at the 1-, 4-, 5- and 6-positions.


An androstanoid that is dehydroepiandrosterone carrying an additional hydroxy substituent at the 7alpha-position.


N(alpha)-acetyl-L-arginine

An N-acetyl-L-amino acid that is L-arginine in which one of the hydrogens attached to the nitrogen is replaced by an acetyl group.


S-(hydroxymethyl)glutathione

An S-substituted glutathione that is glutathione in which the mercapto hydrogen has been replaced by a hydroxymethyl group.


An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.


An HODE (hydroxyoctadecadienoic acid) in which the double bonds are at positions 9 and 11 (E and Z geometry, respectively) and the hydroxy group is at position 13 (with S-configuration).


An oxooctadecadienoic acid that consists of 9Z,11E-octadecadienoic acid bearing an additional 13-keto substituent. In addtion it has been found as a natural product found in Carthamus oxyacantha.


9-hydroxyoctadecadienoic acid

A 9-HODE in which the 9-hydroxy group has S-stereochemistry.


An 11,12-EET in which the epoxy moiety has 11S,12R-configuration.


A HETE having an (8S)-hydroxy group and (5Z)-, (9E)-, (11Z)- and (14Z)-double bonds.


A 16-HETE in which the chiral centre at position 16 has R-configuration.


A HPETE that is (5Z,8Z,10E,12R,14Z)-icosa-5,8,10,14-tetraenoic acid with the hydroperoxy group located at position 12 (the R-enantiomer).


A trihydroxyicosatrienoic acid that is (5Z,8Z,12E)-icosatrienoic acid in which the three hydroxy groups are located at positions 11, 14 and 15.


A HPETE in which the hydroperoxy group is located at position 8S and the four double bonds at position 5, 9, 11 and 14 (the 5Z,9E,11Z,14Z-geoisomer).


An EpOME obtained by formal epoxidation of the 9,10-double bond of octadeca-9,12-dienoic acid (the 12Z-geoisomer).


vernolic acid

A monounsaturated epoxy fatty acid composed of cis-9-octadecenoic acid having a 12,13-epoxy group.


A dialkyl ketone that is heptane in which the two methylene protons at position 4 have been replaced by an oxo group.


oxedrine

A  phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen.


L-proline betaine

An amino acid betaine that is L-proline zwitterion in which both of the hydrogens attached to the nitrogen are replaced by methyl groups.


A beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine in which the acyl group specified is (15Z)-tetracosenoyl.


A beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine in which the acyl group specified is (17Z)-hexacosenoyl.


A beta-D-galactosyl-(1->4)-beta-D-glucosylceramide where the ceramide N-acyl group is specified as hexacosanoyl.


name: hemolytic uremic syndrome, atypical, susceptibility to, 1


N-dodecanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as dodecanoyl (lauroyl).


Fabry disease

description: Fabry disease (FD) is a progressive, inherited, multisystemic lysosomal storage disease characterized by specific neurological, cutaneous, renal, cardiovascular, cochleo-vestibular and cerebrovascular manifestations.


N-oleoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as oleoyl.


N-hexadecanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as hexadecanoyl (palmitoyl).


N-octadecanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as octadecanoyl (stearoyl).


N-icosanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as eicosanoyl.


N-docosanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as docosanoyl.


An N-tetracosenoylsphingosine in which the double bond in the ceramide acyl group is located at position 15 (the Z-geoisomer.


N-hexacosanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as hexacosanoyl.


N-tetracosanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as tetracosanoyl.


N-pentacosanoylsphingosine

A N-acylsphingosine in which the ceramide N-acyl group is specified as pentacosanoyl.


A D-glucosyl-N-acylsphingosine in which the ceramide N-acyl group is dodecanoyl.


beta-D-glucosyl-N-(oleoyl)sphingosine

An N-acyl-beta-D-galactosylsphingosine where the ceramide N-acyl group is specified as oleoyl.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as hexadecanoyl.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as octadecanoyl.


beta-D-glucosyl-N-eicosanoylsphingosine

A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as eicosanoyl.


A beta-D-glucosylceramide where the ceramide N-acyl group is specified as docosanoyl.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as (15Z)-tetracosenoyl.


A beta-D-glucosyl-N-acylsphingosine in which the acyl group is specified as (17Z)-hexacosenoyl.


A beta-D-glucosylceramide where the ceramide N-acyl group is specified as hexacosanoyl.


m-tyramine

A primary amino compound that is 2-phenylethanamine substituted by a hydroxy group at position 3.


benzocaine

A benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina.


codeine

A  morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.


loperamide

A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.


loratadine

A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.


name: PAI1_HUMAN Plasminogen activator inhibitor 1 (sprot)

description: A plasminogen activator inhibitor 1 that is encoded in the genome of human.


CD40L_HUMAN CD40 ligand (sprot)

A tumor necrosis factor ligand superfamily member 5 that is encoded in the genome of human.


name: CODA1_HUMAN Collagen alpha-1(XIII) chain (sprot)

description: A collagen alpha-1(XIII) chain that is encoded in the genome of human.


atorvastatin

A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.


IFNG_HUMAN Interferon gamma (sprot)

An interferon gamma that is encoded in the genome of human.


ITB2_HUMAN Integrin beta-2 (sprot)

An integrin beta-2 that is encoded in the genome of human.


IL6_HUMAN Interleukin-6 (sprot)

An interleukin-6 that is encoded in the genome of human.


name: ICAM1_HUMAN Intercellular adhesion molecule 1 (sprot)

description: An intercellular adhesion molecule 1 that is encoded in the genome of human.


name: BMP2_HUMAN Bone morphogenetic protein 2 (sprot)

description: A bone morphogenetic protein 2 that is encoded in the genome of human.


name: TNR5_HUMAN Tumor necrosis factor receptor superfamily member 5 (sprot)

description: A tumor necrosis factor receptor superfamily member 5 that is encoded in the genome of human.


TNFC_HUMAN Lymphotoxin-beta (sprot)

A lymphotoxin-beta that is encoded in the genome of human.


simvastatin

A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.


name: Lansoprazole Metabolism Pathway,Drug Metabolism


name: Esomeprazole Metabolism Pathway,Drug Metabolism


esomeprazole

A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium salt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.


sertraline

A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.


clopidogrel

A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a  methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.


name: ACM3_HUMAN Muscarinic acetylcholine receptor M3 (sprot)

description: A muscarinic acetylcholine receptor M3 that is encoded in the genome of human.


name: ACM2_HUMAN Muscarinic acetylcholine receptor M2 (sprot)

description: A muscarinic acetylcholine receptor M2 that is encoded in the genome of human.


name: ACM4_HUMAN Muscarinic acetylcholine receptor M4 (sprot)

description: A muscarinic acetylcholine receptor M4 that is encoded in the genome of human.


name: ACM5_HUMAN Muscarinic acetylcholine receptor M5 (sprot)

description: A muscarinic acetylcholine receptor M5 that is encoded in the genome of human.


olanzapine

A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.


celecoxib

A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.


gabapentin

A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.


venlafaxine

A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group.


pantoprazole

A member of the class of  benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2.


amlodipine

A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.


risperidone

A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.


name: ENK11_HUMAN Putative endogenous retrovirus group K member 11-1 Env polyprotein (sprot)


pravastatin

A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.


zolpidem

An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.


escitalopram

A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.


fexofenadine

A piperidine-based anti-histamine compound.


cetirizine

A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.


valdecoxib

A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke.


topiramate

A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.


name: 5HT6R_HUMAN 5-hydroxytryptamine receptor 6 (sprot)

description: A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human.


fluticasone propionate

A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity.


name: AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (sprot)

description: A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human.


sumatriptan

A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.


citalopram

A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer,  escitalopram. It is used as an antidepressant, although only escitalopram is active.


sildenafil

A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.


donepezil

A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.


aripiprazole

An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.


(9E,11E)-octadecadienoic acid

An octadeca-9,11-dienoic acid having 9-trans,11-trans-stereochemistry.


(11Z,14Z)-icosadienoic acid

An icosadienoic acid with double bonds at positions 11 and 14 (both Z).


(R)-oleoylcarnitine

An O-acyl-L-carnitine in which the acyl group is specified as oleoyl.


O-tetradecanoyl-L-carnitine

An O-acyl-L-carnitine in which the acyl group is specified as myristoyl (tetradecanoyl).


15-deoxy-Δ-12,14-prostaglandin J2

A prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions.


12-epi LTB4

A leukotriene that is the 12S-isomer of leukotriene B4.


N-arachidonoylglycine

Biologically active derivative of anandamide


An isoquinolinol that is 1,2,3,4-tetrahydroisoquinoline substituted by a methyl group at position 1 and by hydroxy groups at positions 6 and 7.


TRIPALMITIN

A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by palmitic (hexadecanoic) acid.


The S-enantiomer of 1,2-dioleoyl-3-palmitoylglycerol.


name: CETP_HUMAN Cholesteryl ester transfer protein (sprot)

description: A cholesteryl ester transfer protein that is encoded in the genome of human.


name: APOC3_HUMAN Apolipoprotein C-III (sprot)

description: An apolipoprotein C-III that is encoded in the genome of human.


APOA4_HUMAN Apolipoprotein A-IV (sprot)

An apolipoprotein A-IV that is encoded in the genome of human.


name: CD36_HUMAN Platelet glycoprotein 4 (sprot)

description: A platelet glycoprotein 4 that is encoded in the genome of human.


tristearoylglycerol

A triglyceride that is glycerol in which all three hydroxy groups have been formally esterified with stearic acid.


A triacyl-sn-glycerol in which the acyl groups at positions 1 and 2 are specified as oleoyl while that at position 3 is specifed as stearoyl.


A triglyceride formed by acylation of the three hydroxy groups of glycerol with palmitoleic acid.