ARRB2_HUMAN Beta-arrestin-2 (sprot)

A beta-arrestin-2 that is encoded in the genome of human.


name: BMP3_HUMAN Bone morphogenetic protein 3 (sprot)

description: A bone morphogenetic protein 3 that is encoded in the genome of human.


name: CITE1_HUMAN Cbp/p300-interacting transactivator 1 (sprot)

description: A Cbp/p300-interacting transactivator 1 that is encoded in the genome of human.


CHRD_MOUSE Chordin (sprot)

A chordin that is encoded in the genome of mouse.


name: BMP5_HUMAN Bone morphogenetic protein 5 (sprot)

description: A bone morphogenetic protein 5 that is encoded in the genome of human.


DACT2_HUMAN Dapper homolog 2 (sprot)

A dapper homolog 2 that is encoded in the genome of human.


EGLN_MOUSE Endoglin (sprot)

An endoglin that is encoded in the genome of mouse.


name: BMP5_MOUSE Bone morphogenetic protein 5 (sprot)

description: A bone morphogenetic protein 5 that is encoded in the genome of mouse.


DAB2_RAT Disabled homolog 2 (sprot)

A disabled homolog 2 that is encoded in the genome of rat.


name: CITE2_SAGLB Cbp/p300-interacting transactivator 2 (sprot)


name: BMP6_HUMAN Bone morphogenetic protein 6 (sprot)

description: A bone morphogenetic protein 6 that is encoded in the genome of human.


name: BMP4_HUMAN Bone morphogenetic protein 4 (sprot)

description: A bone morphogenetic protein 4 that is encoded in the genome of human.


DAB2_HUMAN Disabled homolog 2 (sprot)

A disabled homolog 2 that is encoded in the genome of human.


DACH1_MOUSE Dachshund homolog 1 (sprot)

A dachshund homolog 1 that is encoded in the genome of mouse.


name: HS71A_HUMAN Heat shock 70 kDa protein 1A (sprot)

description: A heat shock 70 kDa protein 1A that is encoded in the genome of human.


name: HTRA1_HUMAN Serine protease HTRA1 (sprot)

description: A serine protease HTRA1 that is encoded in the genome of human.


name: HS90B_HUMAN Heat shock protein HSP 90-beta (sprot)

description: A heat shock protein HSP 90-beta that is encoded in the genome of human.


DACH1_HUMAN Dachshund homolog 1 (sprot)

A dachshund homolog 1 that is encoded in the genome of human.


DAB2_MOUSE Disabled homolog 2 (sprot)

A disabled homolog 2 that is encoded in the genome of mouse.


name: DTL_DANRE Denticleless protein homolog (sprot)

description: A denticleless protein that is encoded in the genome of zebrafish.


FOS_HUMAN Protein c-Fos (sprot)

A protein c-Fos that is encoded in the genome of human.


name: BMP8A_MOUSE Bone morphogenetic protein 8A (sprot)

description: A protein that is a translation product of the Bmp8a gene in mouse.


name: BAMBI_HUMAN BMP and activin membrane-bound inhibitor homolog (sprot)

description: A BMP and activin membrane-bound inhibitor that is encoded in the genome of human.


name: FOXH1_HUMAN Forkhead box protein H1 (sprot)

description: A forkhead box protein H1 that is encoded in the genome of human.


name: FBX11_HUMAN F-box only protein 11 (sprot)

description: An F-box only protein 11 that is encoded in the genome of human.


name: HS71B_HUMAN Heat shock 70 kDa protein 1B (sprot)

description: A heat shock 70 kDa protein 1B that is encoded in the genome of human.


name: HTRA3_HUMAN Serine protease HTRA3 (sprot)

description: A serine protease HTRA3 that is encoded in the genome of human.


name: MELT_HUMAN Ventricular zone-expressed PH domain-containing protein homolog 1 (sprot)

description: A ventricular zone-expressed PH domain-containing protein homolog 1 that is encoded in the genome of human.


EGLN_HUMAN Endoglin (sprot)

An endoglin that is encoded in the genome of human.


name: HTR1A_DANRE Serine protease HTRA1A (sprot)

description: A protein that is a translation product of the htra1a gene in zebrafish.


name: LRA25_HUMAN Leucine repeat adapter protein 25 (sprot)

description: A leucine repeat adapter protein 25 that is encoded in the genome of human.


name: HS90B_MOUSE Heat shock protein HSP 90-beta (sprot)

description: A heat shock protein HSP 90-beta that is encoded in the genome of mouse.


PMEPA_HUMAN Protein TMEPAI (sprot)

A protein TMEPAI that is encoded in the genome of human.


name: LTBP4_HUMAN Latent-transforming growth factor beta-binding protein 4 (sprot)

description: A latent-transforming growth factor beta-binding protein 4 that is encoded in the genome of human.


name: MECOM_HUMAN Histone-lysine N-methyltransferase MECOM (sprot)

description: A histone-lysine N-methyltransferase MECOM that is encoded in the genome of human.


name: HS90B_RABIT Heat shock protein HSP 90-beta (sprot)


name: MAN1_HUMAN Inner nuclear membrane protein Man1 (sprot)

description: An inner nuclear membrane protein Man1 that is encoded in the genome of human.


name: LRC32_HUMAN Transforming growth factor beta activator LRRC32 (sprot)

description: A transforming growth factor beta activator LRRC32 that is encoded in the genome of human.


name: GDF2_DANRE Growth/differentiation factor 2 (sprot)

description: A growth/differentiation factor 2 that is encoded in the genome of zebrafish.


name: HTR1B_DANRE Serine protease HTRA1B (sprot)

description: A serine protease HTRA1 that is encoded in the genome of zebrafish.


name: FERM1_HUMAN Fermitin family homolog 1 (sprot)

description: A fermitin family homolog 1 that is encoded in the genome of human.


name: TGBR3_PIG Transforming growth factor beta receptor type 3 (sprot)


name: TGBR3_HUMAN Transforming growth factor beta receptor type 3 (sprot)

description: A TGF-beta receptor type-3 that is encoded in the genome of human.


name: ZBT7A_MOUSE Zinc finger and BTB domain-containing protein 7A (sprot)

description: A zinc finger and BTB domain-containing protein 7A that is encoded in the genome of mouse.


name: LTBP1_HUMAN Latent-transforming growth factor beta-binding protein 1 (sprot)

description: A latent TGF-beta-binding protein 1 that is encoded in the genome of human.


name: TGFB1_HUMAN Transforming growth factor beta-1 proprotein (sprot)

description: A TGF-beta 1 that is encoded in the genome of human.


name: DTL_HUMAN Denticleless protein homolog (sprot)

description: A denticleless protein that is encoded in the genome of human.


name: HMCES_HUMAN Abasic site processing protein HMCES (sprot)

description: An abasic site processing protein HMCES that is encoded in the genome of human.


name: DLDH_MYCTU Dihydrolipoyl dehydrogenase (sprot)


TACY_STRPN Pneumolysin (sprot)

A protein that is a translation product of the ply gene in Streptococcus pneumoniae TIGR4.


name: LAP2B_HUMAN Lamina-associated polypeptide 2, isoforms beta/gamma (sprot)

description: A lamina-associated polypeptide 2 (human), isoforms beta, gamma, and zeta.


name: VSP48_BOTJR Thrombin-like enzyme BJ-48 (Fragment) (sprot)


name: S15A4_RAT Solute carrier family 15 member 4 (sprot)

description: A solute carrier family 15 member 4 that is encoded in the genome of rat.


name: S15A4_HUMAN Solute carrier family 15 member 4 (sprot)

description: A solute carrier family 15 member 4 that is encoded in the genome of human.


name: PEX5_HUMAN Peroxisomal targeting signal 1 receptor (sprot)

description: A peroxisomal targeting signal 1 receptor that is encoded in the genome of human.


name: TPP1_MOUSE Tripeptidyl-peptidase 1 (sprot)

description: A tripeptidyl-peptidase 1 that is encoded in the genome of mouse.


name: TPP1_HUMAN Tripeptidyl-peptidase 1 (sprot)

description: A tripeptidyl-peptidase 1 that is encoded in the genome of human.


name: TPP2_HUMAN Tripeptidyl-peptidase 2 (sprot)

description: A tripeptidyl-peptidase 2 that is encoded in the genome of human.


name: TPP1_DANRE Tripeptidyl-peptidase 1 (sprot)

description: A tripeptidyl-peptidase 1 that is encoded in the genome of zebrafish.


name: PA2AH_TRIST Acidic phospholipase A2 CTs-A2 (Fragment) (sprot)


name: PA2AC_TRIST Acidic phospholipase A2 Ts-A3 (sprot)


name: PA2AG_TRIST Acidic phospholipase A2 CTs-A1 (Fragment) (sprot)


name: PA2AE_TRIST Acidic phospholipase A2 Ts-A5 (Fragment) (sprot)


name: PA2A_TRIGS Acidic phospholipase A2 Tgc-E6 (sprot)


name: PA2BB_TRIST Basic phospholipase A2 Ts-G6D49 (sprot)


name: PA2A_OVOMO Acidic phospholipase A2 Omo-E6 (Fragment) (sprot)


name: PA2AF_TRIST Acidic phospholipase A2 Ts-A6 (sprot)


name: PA2AA_TRIST Acidic phospholipase A2 Ts-A1 (sprot)


name: PA2AI_TRIST Acidic phospholipase A2 CTs-A3 (sprot)


TROPOLONE

A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.


ENTK_HUMAN Enteropeptidase (sprot)

An enteropeptidase that is encoded in the genome of human.


name: CARP1_CANAL Secreted aspartic protease 1 (sprot)

description: A protein that is a translation product of the SAP1 gene in Candida albicans SC5314.


name: CARP5_CANAL Secreted aspartic protease 5 (sprot)

description: A protein that is a translation product of the SAP5 gene in Candida albicans SC5314.


name: CUZD1_HUMAN CUB and zona pellucida-like domain-containing protein 1 (sprot)

description: A CUB and zona pellucida-like domain-containing protein 1 that is encoded in the genome of human.


name: CARP2_CANAL Secreted aspartic protease 2 (sprot)

description: A protein that is a translation product of the SAP2 gene in Candida albicans SC5314.


name: CARP6_CANAL Secreted aspartic protease 6 (sprot)

description: A protein that is a translation product of the SAP6 gene in Candida albicans SC5314.


name: CARP4_CANAL Secreted aspartic protease 4 (sprot)

description: A protein that is a translation product of the SAP4 gene in Candida albicans SC5314.


name: CARP8_CANAL Secreted aspartic protease 8 (sprot)

description: A protein that is a translation product of the SAP8 gene in Candida albicans SC5314.


name: CARP9_CANAL Secreted aspartic protease 9 (sprot)

description: A protein that is a translation product of the SAP9 gene in Candida albicans SC5314.


name: CARP3_CANAL Secreted aspartic protease 3 (sprot)

description: A protein that is a translation product of the SAP3 gene in Candida albicans SC5314.


RGMC_RAT Hemojuvelin (sprot)

A hemojuvelin that is encoded in the genome of rat.


ERFE_HUMAN Erythroferrone (sprot)

An erythroferrone that is encoded in the genome of human.


IL6_MOUSE Interleukin-6 (sprot)

An interleukin-6 that is encoded in the genome of mouse.


name: DDIT3_HUMAN DNA damage-inducible transcript 3 protein (sprot)

description: A DNA damage-inducible transcript 3 protein that is encoded in the genome of human.


GUC2D_RAT Guanylate cyclase 2D (sprot)

A protein that is a translation product of the Gucy2e gene in rat.


name: PDES1_HUMAN Plasmanylethanolamine desaturase 1 (sprot)

description: A plasmanylethanolamine desaturase 1 that is encoded in the genome of human.


name: CARF_MYXXA Plasmanylethanolamine desaturase (sprot)


name: UBIA1_HUMAN UbiA prenyltransferase domain-containing protein 1 (sprot)

description: A UbiA prenyltransferase domain-containing protein 1 that is encoded in the genome of human.


name: UBIA1_DANRE UbiA prenyltransferase domain-containing protein 1 (sprot)

description: A UbiA prenyltransferase domain-containing protein 1 that is encoded in the genome of zebrafish.


name: DNA-(apurinic or apyrimidinic site) endonuclease, initiator methionine removed form (human)

description: A DNA-(apurinic or apyrimidinic site) endonuclease (human) that has had the initiator methionine removed. UniProtKB:P27695, 2-318.


An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof.


Axin-1 isoform 1 (human)

An Axin-1 isoform 1 that is encoded in the genome of human.


Axin-1 ubiquitinated 1 (human)

An Axin-1 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-501 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Lys-501, MOD:01148.


Axin-1 sequence variant L396M (human)

An Axin-1 (human) that has a Met residue at the position equivalent to Leu-396 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, Leu-396, CHEBI:16044.


Axin-1 ADP-ribosylated form (human)

An Axin-1 (human) that includes at least one ADP-ribosylated residue. UniProtKB:O15169, MOD:00752.


Axin-1 isoform 2 (human)

An Axin-1 isoform 2 that is encoded in the genome of human.


Axin-1 phosphorylated 1 (human)

An Axin-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-481, and phosphoserine at positions 486 and 493 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046.


Axin-1 sequence variant Y346* (human)

An Axin-1 (human) that has has been truncated after the position equivalent to Pro-345 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, 1-345.


name: Axin-1 ADP-ribosylated and ubiquitinated form (human)

description: An Axin-1 (human) that includes at least one ADP-ribosylated residue and at least one ubiquitinated lysine. UniProtKB:O15169, MOD:00752|MOD:01148.


Axin-1 sequence variant R354L (human)

An Axin-1 (human) that has a Leu residue at the position equivalent to Arg-354 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, Arg-354, CHEBI:30006.


Axin-1 sequence variant W247* (human)

An Axin-1 (human) that has has been truncated after the position equivalent to Glu-246 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, 1-246.


Axin-1 sequence variant E255S (human)

An Axin-1 (human) that has a Ser residue at the position equivalent to Glu-255 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, Glu-255, CHEBI:29999.


Axin-1 sequence variant E406* (human)

An Axin-1 (human) that has has been truncated after the position equivalent to Ala-405 of the amino acid sequence represented by UniProtKB:O15169-1. Example: UniProtKB:O15169-1, 1-405.


name: circadian locomoter output cycles protein kaput cysteinylated 1 (human)

description: A circadian locomoter output cycles protein kaput (human) that has been cysteinylated on the residue at the position equivalent to Cys-337 of the amino acid sequence represented by UniProtKB:O15516. UniProtKB:O15516, Cys-337, MOD:00765.


name: zinc-alpha-2-glycoprotein N-glycosylated 33 (human)

description: A zinc-alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P25311-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P25311-1, Asn-128, MOD:00160~GNO:G60923RB.


name: serine/threonine-protein kinase VRK2 isoform h4 (human)

description: A serine/threonine-protein kinase VRK2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86Y07-4.


name: potassium voltage-gated channel subfamily H member 5 isoform 3 (human)

description: A voltage-gated potassium channel KCNH5 isoform 3 that is encoded in the genome of human.


14-3-3 protein gamma isoform 1 (human)

A 14-3-3 protein gamma isoform 1 that is encoded in the genome of human.


name: Ral guanine nucleotide dissociation stimulator-like 3 isoform h1 (human)

description: A Ral guanine nucleotide dissociation stimulator-like 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3MIN7-1.


adiponectin O-glycosylated 1 (human)

An adiponectin (human) that has been O-glycosylated at the residue equivalent to Thr-21 of the amino acid sequence represented by UniProtKB:Q15848-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q15848-1, Thr-21, MOD:00005~GNO:G53434XO.


name: alpha-N-acetylgalactosaminidase N-glycosylated 30 (human)

description: An alpha-N-acetylgalactosaminidase (human) that has been N-glycosylated at the residue equivalent to Asn-177 of the amino acid sequence represented by UniProtKB:P17050-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P17050-1, Asn-177, MOD:00160~GNO:G45359RY.


name: UDP-glucuronosyltransferase 2B15 N-glycosylated 1 (human)

description: A UDP-glucuronosyltransferase 2B15 (human) that has been N-glycosylated at the residue equivalent to Asn-316 of the amino acid sequence represented by UniProtKB:P54855-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P54855-1, Asn-316, MOD:00160~GNO:G06247RL.


A member of the class of thiophenes that is thiophene substituted by a carbonyl-L-arginine and (2,1,3-benzothiadiazole-4-sulfonyl)amino groups at positions 2 and 3. It is an inhibitor of the neuropilin-1 and VEGF-A interaction and a potential anti-cancer agent.


name: Ras-related GTP-binding protein A deaminated 1 (human)

description: A Ras-related GTP-binding protein A (human) that has been deaminated on the residue at the position equivalent to Asn-30 of the amino acid sequence represented by UniProtKB:Q7L523. UniProtKB:Q7L523, Asn-30, MOD:00684.


name: excitatory amino acid transporter 4 isoform h1 (human)

description: An excitatory amino acid transporter 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48664-1.


fibrosarcoma of ovary

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A usually aggressive malignant neoplasm arising from the ovary.  It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern.


lung disorder

description: A disease involving the lung.


name: primary pulmonary diffuse large B-cell lymphoma

description: A diffuse large B-cell lymphoma that is localized to the lungs at the time of presentation. Signs and symptoms include cough, dyspnea, and hemoptysis.


non-small cell squamous lung carcinoma

description: A squamous cell carcinoma that arises from the lung. It is characterized by the presence of large malignant cells. It includes the clear cell and papillary variants of squamous cell carcinoma.


lung large cell carcinoma

description: A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection.


name: mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma

description: A rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized by the presence of both mucin and non-mucin producing cells.


pleuropulmonary blastoma type 2

description: A pleuropulmonary blastoma composed of malignant small cells and characterized by the presence of a sarcomatous component. It usually follows an aggressive clinical course.


name: large cell carcinoma with rhabdoid phenotype

description: A rare poorly differentiated morphologic variant of large cell lung carcinoma characterized by the presence of rhabdoid cells.


combined small cell lung carcinoma

description: A morphologic variant of small cell lung carcinoma in combination with a non-small cell carcinoma.


description: A bronchiolo-alveolar adenocarcinoma that is characterized by cells with cuboidal or columnar morphology with eosinophilic or clear cytoplasm and shows Clara cell or type 2 pneumocyte differentiation.


name: epithelial predominant pulmonary blastoma

description: A non-encapsulated, well defined pulmonary blastoma, composed of irregular tubular structures. It affects mostly middle-aged adults and it is rare in children. The prognosis is better compared to the biphasic pulmonary blastoma.


acinar lung adenocarcinoma

description: A morphologic variant of lung adenocarcinoma characterized by the presence of acinar structures composed of columnar or cuboidal cells. (NCI05)


lung hilum carcinoma

description: A lung carcinoma arising from the hilum of the lung.


lung adenocarcinoma

description: A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.


basaloid large cell lung carcinoma

description: A morphologic variant of large cell lung carcinoma characterized by the presence of a solid nodular or anastomotic trabecular growth pattern, peripheral palisading, and comedo type necrosis.


pleuropulmonary blastoma type 3

description: A pleuropulmonary blastoma characterized by a solid pattern and sarcomatous features. It usually follows an aggressive clinical course.


classic pulmonary blastoma

description: A pulmonary blastoma composed of a mixture of irregular tubular structures and mesenchymal elements.


malignant superior sulcus neoplasm

description: A malignant neoplasm originating from the apical lung. Most malignant superior sulcus neoplasms are bronchogenic carcinomas. This tumor may be associated with Pancoast syndrome. It is also known as Pancoast tumor.


name: pulmonary large cell neuroendocrine carcinoma

description: A large cell neuroendocrine carcinoma that involves the lung(s).


pulmonary mucoepidermoid carcinoma

description: A lung carcinoma characterized by the presence of malignant non-keratinizing squamoid cells, mucin-producing cells and intermediate type cells.


asbestos-related lung carcinoma

description: A carcinoma arising in the lung due to exposure to asbestos.


name: lung mixed small cell and squamous cell carcinoma

description: A lung carcinoma characterized by a combination of small cell carcinoma and squamous cell carcinoma.


bronchogenic carcinoma

description: A lung carcinoma arising from the bronchial epithelium.


occult small cell lung carcinoma

description: A small cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed.


lung colloid adenocarcinoma

description: A morphologic variant of lung adenocarcinoma characterized by the presence of mucin pools containing islands of well differentiated adenocarcinoma cells.


lung carcinoma

description: A carcinoma that arises from epithelial cells of the lung


lung occult squamous cell carcinoma

description: A squamous cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed.


lung lymphoma

description: A rare non-Hodgkin or Hodgkin lymphoma that arises in and is confined to the lung at the time of diagnosis.


lung inflammatory myofibroblastic tumor

description: An intermediate fibroblastic neoplasm arising from the lung. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells.


lung non-Hodgkin lymphoma

description: A rare non-Hodgkin lymphoma that arises in and is confined to the lung at the time of diagnosis. Representative examples include bronchial mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma.


description: A bronchiolo-alveolar adenocarcinoma that is characterized by a tumor cells containing abundant mucin in their cytoplasm and composed of tall columnar cells growing along alveolar walls without stromal invasion.


lymphoepithelioma-like lung carcinoma

description: A morphologic variant of large cell lung carcinoma characterized by the presence of a syncytial growth pattern, large vesicular nuclei with esophnophilic nucleoi, and dense lymphoplasmacytic infiltration.


lung occult large cell carcinoma

description: A large cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed.


minimally invasive lung adenocarcinoma

description: A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is characterized by a predominantly lepidic pattern and 5 mm or less invasion in greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely may be mucinous.


lung adenocarcinoma in situ

description: A localized non-invasive adenocarcinoma of the lung measuring 3 cm or less. It is characterized by a pure lepidic growth pattern and the lack of stromal, vascular, or pleural invasion.


lung neoplasm

description: A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma.


name: large cell lung carcinoma, clear cell variant

description: A morphologic variant of large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen.


small cell lung carcinoma

description: Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure.


adenosquamous lung carcinoma

description: An aggressive carcinoma with a poor prognosis characterized by a presence of both malignant squamous cells and glandular cells.


name: lung combined large cell neuroendocrine carcinoma

description: A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma.


lung signet ring cell carcinoma

description: A morphologic variant of lung adenocarcinoma characterized by the presence of signet ring cells.


pleuropulmonary blastoma

description: A malignant neoplasm affecting the lungs and/or the pleura. Pleuropulmonary blastoma is seen in children. Microscopically, the tumor may show features of chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated sarcoma. In approximately 25% of patients with pleuropulmonary blastoma, there are other lesions or neoplasms that may affect patients or their families, including lung or kidney cysts, and ovarian or testicular neoplasms. Heterozygous germline mutations in DICER1 gene have been identified in families harboring pleuropulmonary blastomas.


non-small cell lung carcinoma

description: A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.


squamous cell lung carcinoma

description: A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma.


name: lung combined type small cell adenocarcinoma

description: A lung combined type small cell carcinoma that has material basis in epithelial tissue of glandular origin.


bronchus mucoepidermoid carcinoma

description: A mucoepidermoid carcinoma that involves the bronchus.


name: well-differentiated fetal adenocarcinoma of the lung

description: Well-differentiated fetal adenocarcinoma (WDFA) of the lung is a rare, primary, low-grade, bronchopulmonary neoplasm characterized by a well-circumscribed, usually large, pulmonary mass that is histologically composed of glycogen-rich neoplastic glands and tubules that resemble fetal lungs at 10 to 16 weeks of gestation and benign adjacent stroma. It typically presents with chest pain, cough, dyspnea, hemoptysis and/or generalized, non-specific symptoms, such as night sweats, lethargy, poor appetite and weight loss.


lung epithelial-myoepithelial carcinoma

description: A lung carcinoma arising within the bronchi or bronchial tubes. It is characterized by the presence of myoepithelial cells, spindle cells, clear cells, and duct-forming epithelial cells. Surgical resection may be curative.


lung occult adenocarcinoma

description: A lung adenocarcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed.


papillary lung adenocarcinoma

description: A morphologic variant of lung adenocarcinoma characterized by the presence of papillary structures.


lung leiomyosarcoma

description: An aggressive malignant smooth muscle neoplasm, arising from the lung. It is characterized by a proliferation of neoplastic spindle cells.


pulmonary blastoma

description: A malignant neoplasm of the lung composed of tubular structures and immature mesenchymal elements, which may differentiate towards skeletal and smooth muscle, cartilage or a combination of muscle and cartilage. This is a nodular tumor found in the periphery of the lung. It can occur at any age. The prognosis is related to the stage of the disease at the time of resection. Pulmonary blastoma is divided into two subtypes: epithelial predominant and biphasic.


lung sarcomatoid carcinoma

description: A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor.


pleuropulmonary blastoma type 1

description: A pleuropulmonary blastoma composed of malignant small cells. Sarcomatous features are absent.


lung pleomorphic carcinoma

description: A pleomorphic carcinoma that is characterized by the presence of malignant glandular or squamous cells associated with malignant giant and spindle cells and that is located in the lung.


lung giant cell carcinoma

description: A morphologic variant of lung sarcomatoid carcinoma characterized by the presence of mononuclear and multinucleated pleomorphic neoplastic giant cells that lack cohesion.


lung adenoid cystic carcinoma

description: A rare usually indolent lung carcinoma characterized by a cribiform and tubular pattern and the presence of glandular epithelial cells. Clinical symptoms include shortness of breath, cough, wheeze, hemopytsis and chest pain.


name: solid adenocarcinoma with mucin production


combined lung carcinoma

description: A lung carcinoma characterized by the presence of large or small neuroendocrine carcinoma cells in combination with malignant glandular or squamous epithelial cells.


lung meningioma

description: A primary or metastatic meningioma that is present in the lung. The lung is the most frequent site of metastasis of meningiomas.


lung hilum cancer

description: A malignant neoplasm involving the lung hilus.


lung sarcoma

description: A malignant mesenchymal neoplasm that arises from the lung. Representative examples include Kaposi sarcoma, leiomyosarcoma, and synovial sarcoma.


lung carcinoma in situ

description: A carcinoma in situ involving a lung.


bronchus carcinoma in situ

description: A carcinoma in situ involving a bronchus.


lung superior sulcus carcinoma

description: A carcinoma originating from the apical lung. Most superior sulcus lung carcinomas are bronchogenic carcinomas. This carcinoma may be associated with Pancoast syndrome. lt is also known as Pancoast tumor.


Graham-Boyle-Troxell syndrome

description: Cystic hamartoma of lung and kidney is a rare developmental malformation reported in 3 patients characterized by the presence of benign hamartomatous cysts in kidney and lung, clinically presenting as abdominal mass. Others associated features include hyperplastic nephromegaly, medullary dysplasia and mesoblastic nephroma. There have been no further descriptions in the literature since 1987.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A deaminated 1 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (human) that has been deaminated on the residue at the position equivalent to Asn-545 of the amino acid sequence represented by UniProtKB:P46977-1. Example: UniProtKB:P46977-1, Asn-545, MOD:00684.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h2 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-2.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3 that is encoded in the genome of human.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h1 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-1.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform h4 (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99640-4.


name: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase phosphorylated form (human)

description: A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) that includes at least one phosphorylated residue. UniProtKB:Q99640, MOD:00696.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 methylated 1 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has been methylated on the residue at the position equivalent to Cys-477 of the amino acid sequence represented by UniProtKB:P04843. UniProtKB:P04843, Cys-477, MOD:00660.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

description: A protein that is a translation product of the human RPN1 gene or a 1:1 ortholog thereof.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 deaminated 2 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has been deaminated on the residue at the position equivalent to Gln-269 of the amino acid sequence represented by UniProtKB:P04843. UniProtKB:P04843, Gln-269, MOD:00685.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, signal peptide removed form (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has had the signal peptide removed. UniProtKB:P04843, 24-607.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 deaminated 1 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has been deaminated on the residue at the position equivalent to Gln-211 of the amino acid sequence represented by UniProtKB:P04843. UniProtKB:P04843, Gln-211, MOD:00685.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 cysteinylated 1 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-545 of the amino acid sequence represented by UniProtKB:P04843. UniProtKB:P04843, Cys-545, MOD:00765.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 deaminated 3 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (human) that has been deaminated on the residue at the position equivalent to Asn-299 of the amino acid sequence represented by UniProtKB:P04843. UniProtKB:P04843, Asn-299, MOD:00684.


name: all-trans-retinol 13,14-reductase methylated 1 (human)

description: An all-trans-retinol 13,14-reductase (human) that has been methylated on the residue at the position equivalent to Cys-347 of the amino acid sequence represented by UniProtKB:Q6NUM9-1. Example: UniProtKB:Q6NUM9-1, Cys-347, MOD:00660.


name: Ras-specific guanine nucleotide-releasing factor RalGPS2 isoform h3 (human)

description: A Ras-specific guanine nucleotide-releasing factor RalGPS2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86X27-3.


name: testis-specific serine/threonine-protein kinase 3 isoform 1 (human)

description: A testis-specific serine/threonine-protein kinase 3 isoform 1 that is encoded in the genome of human.


name: serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 (human)

description: A serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1 that is encoded in the genome of human.


name: ADP-ribosylation factor GTPase-activating protein 1 isoform h2 (human)

description: An ADP-ribosylation factor GTPase-activating protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N6T3-2.


name: ubiquitin carboxyl-terminal hydrolase 51 cysteinylated 1 (human)

description: A ubiquitin carboxyl-terminal hydrolase 51 (human) that has been cysteinylated on the residue at the position equivalent to Cys-593 of the amino acid sequence represented by UniProtKB:Q70EK9. UniProtKB:Q70EK9, Cys-593, MOD:00765.


arginine derivative

An amino acid derivative resulting from reaction of arginine at the amino group, the carboxy group, or the guanidyl group, or from the replacement of any hydrogen of arginine by a heteroatom. The definition normally excludes peptides containing arginine residues.


L-arginine derivative

A proteinogenic amino acid derivative resulting from reaction of L-arginine at the amino group, the carboxy group, or the guanidyl group, or from the replacement of any hydrogen of L-arginine by a heteroatom.


dimethylarginine

An arginine derivative that is arginine substituted by two methyl groups. A "closed" class.


name: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform h2 (human)

description: A dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04844-2.


name: zinc finger FYVE domain-containing protein 9 isoform 2 (human)

description: A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of human.


name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h1 (human)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-1.


name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

description: A protein that is a translation product of the human NDUFS7 gene or a 1:1 ortholog thereof.


name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, transit peptide removed form (human)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that has had the transit peptide removed. UniProtKB:O75251, 39-213.


name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform h2 (human)

description: An NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75251-2.


hypothyroidism

description: Abnormally low levels of thyroid hormone.


congenital hypothyroidism

description: A thyroid hormone deficiency present from birth.


ceramide synthase 5 isoform h2 (human)

A ceramide synthase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8N5B7-2.


(R)-diethylpropion

The (R)-enantiomer of amfepramone.


name: histone-lysine N-methyltransferase MECOM isoform 7 (human)

description: A histone-lysine N-methyltransferase MECOM isoform 7 that is encoded in the genome of human.


name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h1 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-1.


name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h3 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-3.


name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h4 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-4.


name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h2 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-2.


name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h7 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-7.


name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h6 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-6.


name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform h5 (human)

description: A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6XPS3-5.


name: Platinum-Sensitive Endometrial Serous Adenocarcinoma

description: An endometrial serous adenocarcinoma that has a documented response to platinum-based chemotherapy.


name: FERM, ARHGEF and pleckstrin domain-containing protein 1 phosphorylated 2 (human)

description: A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-185 of the amino acid sequence represented by UniProtKB:Q9Y4F1-1. Example: UniProtKB:Q9Y4F1-1, Tyr-185, MOD:00048.


name: FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h1 (human)

description: A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-1.


name: FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h2 (human)

description: A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-2.


name: FERM, ARHGEF and pleckstrin domain-containing protein 1 phosphorylated 1 (human)

description: A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-36 of the amino acid sequence represented by UniProtKB:Q9Y4F1-1. Example: UniProtKB:Q9Y4F1-1, Ser-36, MOD:00046.


name: FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform h3 (human)

description: A FERM, ARHGEF and pleckstrin domain-containing protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4F1-3.


name: tyrosine-protein kinase SYK isoform Long (human)

description: A tyrosine-protein kinase SYK isoform 1 that is encoded in the genome of human.


name: ubiquitin carboxyl-terminal hydrolase 11 cysteinylated 2 (human)

description: A ubiquitin carboxyl-terminal hydrolase 11 (human) that has been cysteinylated on the residue at the position equivalent to Cys-482 of the amino acid sequence represented by UniProtKB:P51784. UniProtKB:P51784, Cys-482, MOD:00765.


name: GRB2-associated-binding protein 1 phosphorylated 1 (human)

description: A GRB2-associated-binding protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 447, 472, 589, 627 and 659 of the amino acid sequence represented by UniProtKB:Q13480. UniProtKB:Q13480, Tyr-447/Tyr-472/Tyr-589/Tyr-627/Tyr-659, MOD:00048.


name: GRB2-associated-binding protein 1 isoform h1 (human)

description: A GRB2-associated-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13480-1.


name: GRB2-associated-binding protein 1 phosphorylated 2 (human)

description: A GRB2-associated-binding protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 627 and 659 of the amino acid sequence represented by UniProtKB:Q13480. UniProtKB:Q13480, Tyr-627/Tyr-659, MOD:00048.


name: GRB2-associated-binding protein 1 isoform h2 (human)

description: A GRB2-associated-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13480-2.


name: GRB2-associated-binding protein 1 phosphotyrosine form (human)

description: A GRB2-associated-binding protein 1 (human) that includes at least 1 phosphorylated tyrosine. UniProtKB:Q13480, MOD:00048.


name: elongation factor 1-delta, initiator methionine removed form (human)

description: An elongation factor 1-delta (human) that has had the initiator methionine removed. UniProtKB:P29692, 2-281.


name: alpha-2A adrenergic receptor phosphorylated 1 (human)

description: An alpha-2A adrenergic receptor (human) that has been phosphorylated on the residue at the position equivalent to Tyr-156 of the amino acid sequence represented by UniProtKB:P08913. UniProtKB:P08913, Tyr-156, MOD:00048.


name: nuclear factor of activated T-cells, cytoplasmic 4 isoform h16 (human)

description: A nuclear factor of activated T-cells, cytoplasmic 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14934-16.


name: serine protease 1, signal peptide removed form (human)

description: A serine protease 1 (human) that has had the signal peptide removed. UniProtKB:P07477, 16-247.


name: Pulmonary myxoid sarcoma with EWSR1-CREB1 translocation

description: A sarcoma that arises from the lung. It is related to a bronchus and is often predominantly endobronchial. It is characterized by the proliferation of round and spindle cells within a myxoid stroma. It is associated with the presence of an EWSR1::CREB1 fusion gene.


name: N-acetylneuraminate lyase isoform h2 (human)

description: An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-2.


N-acetylneuraminate lyase

A protein that is a translation product of the human NPL gene or a 1:1 ortholog thereof.


name: N-acetylneuraminate lyase isoform h4 (human)

description: An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-4.


name: N-acetylneuraminate lyase isoform h3 (human)

description: An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-3.


name: N-acetylneuraminate lyase isoform 1 (mouse)

description: An N-acetylneuraminate lyase isoform 1 that is encoded in the genome of mouse.


name: N-acetylneuraminate lyase isoform h5 (human)

description: An N-acetylneuraminate lyase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BXD5-5.


name: N-acetylneuraminate lyase isoform 1 (human)

description: An N-acetylneuraminate lyase isoform 1 that is encoded in the genome of human.


name: calcium/calmodulin-dependent protein kinase type II subunit gamma isoform h2 (human)

description: A calcium/calmodulin-dependent protein kinase type II subunit gamma (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13555-2.


name: myotubularin-related protein 4 methylated 1 (human)

description: A myotubularin-related protein 4 (human) that has been methylated on the residue at the position equivalent to Cys-486 of the amino acid sequence represented by UniProtKB:Q9NYA4. UniProtKB:Q9NYA4, Cys-486, MOD:00660.


name: Locally Advanced Lung Small Cell Carcinoma

description: Lung small cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


avicholic acid

A trihydroxy-5beta-cholanic acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3, 7 and 16 (the 3alpha,7alpha,16alpha stereoisomer). It is a major constituent of the bile of several avian species.


16alpha-hydroxy steroid

A 16-hydroxy steroid in which the hydroxy group at position 16 has alpha-configuration.


homoavicholic acid

A 3alpha-hydroxy steroid that is avicholic acid that contains an extra methylene (CH2) group at position 24.


estetrol

A 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver.


estriol 3-O-(beta-D-glucuronide)

A  steroid glucosiduronic acid that is the 3-beta-D-glucuronide of estriol; a steroid hormone ligand recognised by the monoclonal antibody 4155.


A 3-hydroxy steroid that is estriol carrying an oxo group at position 6.


A C19-steroid that is testosterone in which the hydrogen at the 16alpha position has been replaced by a hydroxy group.


A pregnane sterol that is pregnenolone substituted by two hydroxy groups at positions 16 and 17 (16alpha,17alpha-stereoisomer).


An androstanoid that is dehydroepiandrosterone 3-sulfate substituted by a hydroxy group at the 16alpha-position.


A 16alpha-hydroxy steroid that is estriol in which the hydroxy group at position 17 has been epimersied from beta- to alpha- configuration. It is a metabolite of estradiol and a selective estrogen receptor beta (ER-beta) agonist.


A steroid glucosiduronic acid that is 16alpha-hydroxyestrone in which the phenolic hydrogen has been replaced by a beta-D-glucuronyl residue.


A 3-oxo-Delta(4) steroid that is progesterone substituted by hydroxy groups at positions 6, 16 and 17 (6beta,16alpha,17alpha-stereoisomer).


A 16alpha-hydroxy steroid that is  estriol in which the hydroxy group at position 3 is replaced by an allyloxy group.


algestone

A C21-steroid that is pregn-4-ene substituted by oxo groups at position 3 and 20 and hydroxy groups at positions 16 and 17.


triamcinolone

A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections.


name: Rho GTPase-activating protein 45 isoform h2 (human)

description: A Rho GTPase-activating protein 45 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92619-2.


name: Rho GTPase-activating protein 45 isoform h1 (human)

description: A Rho GTPase-activating protein 45 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92619-1.


(+)-sulpiride

An optically active form of sulpiride having (R)-configuration. The active enantiomer of the racemic drug sulpiride.


(-)-sulpiride

An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, D1 and D5 receptors respectively).


organic anion

Any organic ion with a net negative charge.


A 1-alkyl-2-acyl-sn-glycero-3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of 1-(9Z-octadecenyl)-2-arachidonoyl-sn-glycero-3-phosphate; major species at pH 7.3.


A 1-(Z)-alk-1-enyl-2-acyl-sn-glycero-3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of 1-[(1Z)-octadecenyl]-2-oleoyl-sn-glycero-3-phosphate; major species at pH 7.3.


dicarboxylic acid dianion

A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid.


pyridoxal 5'-phosphate(2-)

The dianion resulting from the removal of two protons from the phosphate group of pyridoxal 5'-phosphate.


organophosphate oxoanion

An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated.


salicylates

Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.


carboxylic acid dianion

Any dianion containing at least one carboxy group.


An androstane sulfate that is 5alpha-androstan-3alpha,17beta-diol in which the hydroxy hydrogen at position 3 has been replaced by a sulfo group.


pyridoxamine 5'-phosphate(1-)

An organophosphate oxoanion that is the conjugate base of pyridoxamine 5'-phosphate.


oxo carboxylic acid anion

Any carboxylic acid anion containing at least one oxo group.


A 1-alkyl-2-acyl-sn-glycero-3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of 1-palmityl-2-acetyl-sn-glycero-3-phosphate; major species at pH 7.3.


hexuronate

A uronate obtained via deprotonation of the carboxy group of any hexuronic acid.


A 1-alkyl-2-acyl-sn-glycero-3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of 1-palmityl-2-oleoyl-sn-glycero-3-phosphate; major species at pH 7.3.


oxo dicarboxylic acid dianion

A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of any oxo dicarboxylic acid.


carbamate

Any ester of carbamic acid or its N-substituted derivatives.


A 1-alkyl-2-acyl-sn-glycero-3-phosphate(2-) in which the 1-alkyl substituent can be any alk-1-enyl group. Major species at pH 7.3.


A 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of any 1-(Z)-alk-1-enyl-2-acyl-sn-glycero-3-phosphate; major species at pH 7.3.


monocarboxylic acid anion

A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated.


carboxylic acid anion

The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated.


UDP-L-iduronic acid

A UDP-sugar in which the sugar component is L-iduronic acid.


thiamine(1+) triphosphate(4-)

Trianion of thiamine(1+) diphosphate arising from deprotonation of the four OH groups of the triphosphate.


A 1-alkyl-2-acyl-sn-glycero-3-phosphate(2-) obtained by deprotonation of the phosphate OH groups of 1-palmityl-2-arachidonoyl-sn-glycero-3-phosphate; major species at pH 7.3.


pyridoxine 5'-phosphate(2-)

Dianion of pyridoxine 5'-phosphate.


thiamine(1+) diphosphate(3-)

Dianion of thiamine(1+) diphosphate arising from deprotonation of the three OH groups of the diphosphate.


A pyridoxate that is the conjugate base of 4-pyridoxic acid, obtained by deprotonation of the carboxy group.


thiamine(1+) monophosphate(2-)

An organophosphate oxoanion that is the conjugate base of thiamine(1+) monophosphate(1-), arising from the deprotonation of the phosphate group. Major microspecies at pH 7.3.


A phenolate anion that is the conjugate base of 2',4,4',6'-tetrahydroxychalcone, obtained by deprotonation of the phenolic hydroxy group at position 2'; major species at pH 7.3.


An anionic phospholipid obtained by deprotonation of the phosphate OH groups of any 1-alkyl-2-acyl-sn-glycero-3-phosphate.


A cyclic tetrapyrrole anion obtained by deprotonation of the carboxy groups of siroheme; major species at pH 7.3.


name: transcriptional regulator ATRX sequence variant Q176* (human)

description: A transcriptional regulator ATRX (human) that has has been truncated after the position equivalent to Gly-175 of the amino acid sequence represented by UniProtKB:P46100-1. Example: UniProtKB:P46100-1, 1-175.


name: fibrinogen gamma chain, signal peptide removed form (human)

description: A fibrinogen gamma chain (human) that has had the signal peptide removed. UniProtKB:P02679, 27-453.


name: inositol 1,4,5-triphosphate receptor associated 1 isoform 1 phosphorylated 1 (human)

description: An inositol 1,4,5-triphosphate receptor associated 1 isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6F6-1, Ser-657/Ser-670, MOD:00046.


name: inositol 1,4,5-triphosphate receptor associated 1 isoform 1 (human)

description: An inositol 1,4,5-triphosphate receptor associated 1 isoform 1 that is encoded in the genome of human.


bone marrow disorder

description: Any disease of the bone marrow.


Abnormal granulocyte morphology

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Any structural abnormality or abnormal count of granulocytes.


normocytic anemia

description: Anemia in which the red blood cell volume is normal.


agranulocytosis

description: A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood.


hemolytic anemia

description: Anemia resulting from the premature destruction of the peripheral blood red cells. It may be congenital or it may be caused by infections, medications, or malignancies.


megaloblastic anemia

description: Anemia characterized by the presence of unusually large erythroblasts in the bone marrow called megaloblasts. It is usually caused by vitamin B12 or folic acid deficiency. Other causes include toxins and drugs.


Abnormal myeloid cell morphology

description: Any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.


sideroblastic anemia

description: A group of rare heterogeneous inherited or acquired bone marrow disorders, isolated or part of a syndrome, characterized by decreased hemoglobin synthesis, because of defective use of iron (although plasmatic iron levels may be normal or elevated) and the presence of ringed sideroblasts in the bone marrow due to the pathologic iron overload in mitochondria as visualized by Perls' staining. The group encompasses (idiopathic) acquired sideroblastic anemia and constitutional sideroblastic anemias. The latter include syndromic sideroblastic anemias such as Pearson syndrome, mitochondrial mypathy and sideroblastic anemias, x-linked sideroblastic anemia-ataxia, thiamine responsive megaloblastic anemia syndrome and nonsyndromic sideroblastic anemias comprising x-linked and autosomal recessive sideroblastic anemias.


anemia

description: A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.


Abnormal mast cell morphology

description: Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation.


Abnormal myeloid leukocyte morphology

description: An abnormality of myeloid leukocytes.


mastocytosis

description: A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival.


macrocytic anemia

description: Anemia that is characterized by increased red blood cell volume.


familial hemolytic anemia

description: A congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies.


neutropenia

description: A decrease in the number of neutrophils found in the blood.


name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 (human)

description: A 5'-AMP-activated protein kinase catalytic subunit alpha-2 unphosphorylated 1 in human. UniProtKB:P54646, Thr-172, PR:000026291.


name: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform h2 (human)

description: A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15118-2.


(S)-imazapyr

A 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinic acid that has S configuration.


name: S-adenosylhomocysteine hydrolase-like protein 1 phosphorylated 1 (human)

description: An S-adenosylhomocysteine hydrolase-like protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-103 of the amino acid sequence represented by UniProtKB:O43865-1. Example: UniProtKB:O43865-1, Ser-103, MOD:00046.


protocadherin-15 isoform h3 (human)

A protocadherin-15 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96QU1-3.


protein tyrosine phosphatase type IVA 3

A protein that is a translation product of the human PTP4A3 gene or a 1:1 ortholog thereof.


name: protein tyrosine phosphatase type IVA 3 cysteinylated 1 (human)

description: A protein tyrosine phosphatase type IVA 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-49 of the amino acid sequence represented by UniProtKB:O75365-1. Example: UniProtKB:O75365-1, Cys-49, MOD:00765.


name: protein tyrosine phosphatase type IVA 3 isoform 1 (human)

description: A protein tyrosine phosphatase type IVA 3 isoform 1 that is encoded in the genome of human.


name: protein tyrosine phosphatase type IVA 3 isoform h2 (human)

description: A protein tyrosine phosphatase type IVA 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75365-2.


name: protein tyrosine phosphatase type IVA 3 isoform h3 (human)

description: A protein tyrosine phosphatase type IVA 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75365-3.


sterol biosynthesis disorder

description: An inherited metabolic disease that is has its basis in the disruption of sterol biosynthetic process.


X-linked chondrodysplasia punctata

description: X-linked form of chondrodysplasia punctata.


name: cholesterol biosynthetic process disease

description: A disease that has its basis in the disruption of cholesterol biosynthetic process.


name: mitochondrial 10-formyltetrahydrofolate dehydrogenase isoform 1 (human)

description: A mitochondrial 10-formyltetrahydrofolate dehydrogenase isoform 1 that is encoded in the genome of human.


name: NADPH:adrenodoxin oxidoreductase, mitochondrial isoform Long (human)

description: An NADPH:adrenodoxin oxidoreductase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22570-2.


name: glucosidase 2 subunit beta O-glycosylated 6 (human)

description: A glucosidase 2 subunit beta (human) that has been O-glycosylated at the residue equivalent to Thr-287 of the amino acid sequence represented by UniProtKB:P14314-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P14314-1, Thr-287, MOD:00005~GNO:G43417UB.


name: prolyl 3-hydroxylase 3, signal peptide removed form (human)

description: A prolyl 3-hydroxylase 3 (human) that has had the signal peptide removed. Example: UniProtKB:Q8IVL6-1, 21-736.


name: inorganic pyrophosphatase 2, mitochondrial, transit peptide removed form (human)

description: An inorganic pyrophosphatase 2, mitochondrial (human) that has had the transit peptide removed. UniProtKB:Q9H2U2, 33-334.


name: solute carrier family 13 member 2 isoform h1 (human)

description: A solute carrier family 13 member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13183-1.


name: trifunctional purine biosynthetic protein adenosine-3 isoform Short (human)

description: A trifunctional purine biosynthetic protein adenosine-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22102-2.


name: zinc finger protein 638 isoform h2 (human)

description: A zinc finger protein 638 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14966-2.


name: Rho-related GTP-binding protein RhoU phosphorylated 1 (human)

description: A Rho-related GTP-binding protein RhoU (human) that has been phosphorylated on the residue at the position equivalent to Tyr-254 of the amino acid sequence represented by UniProtKB:Q7L0Q8-1. Example: UniProtKB:Q7L0Q8-1, Tyr-254, MOD:00048.


name: Rho-related GTP-binding protein RhoU isoform h1 (human)

description: A Rho-related GTP-binding protein RhoU (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7L0Q8-1.


name: Rho-related GTP-binding protein RhoU isoform h2 (human)

description: A Rho-related GTP-binding protein RhoU (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7L0Q8-2.


(S)-orciprenaline

A 5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol that is the (S)-enantiomer of orciprenaline.


(R)-orciprenaline

A 5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol that is the (R)-enantiomer of orciprenaline.


lysophosphatidic acid receptor 1

A lysophospholipid (LPA) receptor that is a translation product of the human LPAR1 gene or a 1:1 ortholog thereof. It is expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testis, spleen, skeletal muscle, and kidney. There is little or no expression in liver, lung, thymus, or peripheral blood leukocytes.


name: lysophosphatidic acid receptor 1 isoform 1 (human)

description: A lysophosphatidic acid receptor 1 isoform 1 that is encoded in the genome of human.


name: lysophosphatidic acid receptor 1 isoform h2 (human)

description: A lysophosphatidic acid receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92633-2.


name: cation-independent mannose-6-phosphate receptor deaminated 4 (human)

description: A cation-independent mannose-6-phosphate receptor (human) that has been deaminated on the residue at the position equivalent to Gln-777 of the amino acid sequence represented by UniProtKB:P11717. UniProtKB:P11717, Gln-777, MOD:00685.


name: PALM2-AKAP2 fusion protein cysteinylated 1 (human)

description: A PALM2-AKAP2 fusion protein (human) that has been cysteinylated on the residue at the position equivalent to Cys-436 of the amino acid sequence represented by UniProtKB:Q9Y2D5-4. Example: UniProtKB:Q9Y2D5-4, Cys-436, MOD:00765.


malignant struma ovarii

description: An ovarian mature teratoma characterized by the presence of aberrant thyroid tissue with morphologic changes identical to thyroid carcinoma. Patients may present with abdominal mass and unusual symptoms due to thyrotoxicosis, or with Meigs syndrome (ascites and pleural effusion).


name: NADH dehydrogenase [ubiquinone] 1 subunit C2 methylated 1 (human)

description: An NADH dehydrogenase [ubiquinone] 1 subunit C2 (human) that has been methylated on the residue at the position equivalent to Phe-115 of the amino acid sequence represented by UniProtKB:O95298-1. Example: UniProtKB:O95298-1, Phe-115, MOD:00717.


name: NADH dehydrogenase [ubiquinone] 1 subunit C2

description: A protein that is a translation product of the human NDUFC2 gene or a 1:1 ortholog thereof.


name: NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform 3 (human)

description: An NADH dehydrogenase [ubiquinone] 1 subunit C2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95298-1.


name: NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform 5 (human)

description: An NADH dehydrogenase [ubiquinone] 1 subunit C2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95298-3.


name: NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform 4 (human)

description: An NADH dehydrogenase [ubiquinone] 1 subunit C2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95298-2.


name: DNA-directed RNA polymerase II subunit RPB7 cysteinylated 2 (human)

description: A DNA-directed RNA polymerase II subunit RPB7 (human) that has been cysteinylated on the residue at the position equivalent to Cys-106 of the amino acid sequence represented by UniProtKB:P62487. UniProtKB:P62487, Cys-106, MOD:00765.


name: ATP-binding cassette sub-family B member 10, mitochondrial methylated 1 (human)

description: An ATP-binding cassette sub-family B member 10, mitochondrial (human) that has been methylated on the residue at the position equivalent to Cys-100 of the amino acid sequence represented by UniProtKB:Q9NRK6. UniProtKB:Q9NRK6, Cys-100, MOD:00660.


name: serotransferrin N-glycosylated 35 (human)

description: A serotransferrin (human) that has been N-glycosylated at the residue equivalent to Asn-630 of the amino acid sequence represented by UniProtKB:P02787-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P02787-1, Asn-630, MOD:00160~GNO:G36191CD.


name: aryl hydrocarbon receptor deaminated 1 (human)

description: An aryl hydrocarbon receptor (human) that has been deaminated on the residue at the position equivalent to Asn-105 of the amino acid sequence represented by UniProtKB:P35869. UniProtKB:P35869, Asn-105, MOD:00684.


name: eIF-2-alpha kinase GCN2 isoform h1 (human)

description: An eIF-2-alpha kinase GCN2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P2K8-1.


name: bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 (human)

description: A bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform 1 that is encoded in the genome of human.


A cadherin that is a translation product of the human CDH15 gene or a 1:1 ortholog thereof.


name: serine/threonine-protein kinase Nek2 isoform h3 (human)

description: A serine/threonine-protein kinase Nek2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51955-3.


name: vitamin K-dependent protein C N-glycosylated 25 (human)

description: A vitamin K-dependent protein C (human) that has been N-glycosylated at the residue equivalent to Asn-355 of the amino acid sequence represented by UniProtKB:P04070-1, in which the glycan structure is represented by GlyTouCan:G42440OJ. Example: UniProtKB:P04070-1, Asn-355, MOD:00160~GNO:G42440OJ.


rhotekin phosphorylated 1 (human)

A rhotekin (human) that has been phosphorylated on the residue at the position equivalent to Thr-465 of the amino acid sequence represented by UniProtKB:Q9BST9-1. Example: UniProtKB:Q9BST9-1, Thr-465, MOD:00047.


EPIESTRIOL

A 3-hydroxy steroid that is 17beta-estradiol substituted by a beta-hydroxy group at position 16.


name: aggrecan core protein O-glycosylated 84 (human)

description: An aggrecan core protein (human) that has been O-glycosylated at the residue equivalent to Thr-2223 of the amino acid sequence represented by UniProtKB:P16112-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P16112-1, Thr-2223, MOD:00005~GNO:G53434XO.


name: alpha-fetoprotein N-glycosylated 13 (human)

description: An alpha-fetoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-251 of the amino acid sequence represented by UniProtKB:P02771-1, in which the glycan structure is represented by GlyTouCan:G43694RQ. Example: UniProtKB:P02771-1, Asn-251, MOD:00160~GNO:G43694RQ.


name: E3 ubiquitin-protein ligase NEDD4-like isoform h2 (human)

description: An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-2.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 9 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-182 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q96PD5-1, Thr-182, MOD:00005~GNO:G43417UB.


name: N-acetylmuramoyl-L-alanine amidase N-glycosylated 3 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been N-glycosylated at the residue equivalent to Asn-485 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:Q96PD5-1, Asn-485, MOD:00160~GNO:G42358LZ.


name: N-acetylmuramoyl-L-alanine amidase isoform h2 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PD5-2.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 3 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-168 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q96PD5-1, Thr-168, MOD:00005~GNO:G29068FM.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 8 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-182 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q96PD5-1, Thr-182, MOD:00005~GNO:G29068FM.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 6 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-181 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q96PD5-1, Thr-181, MOD:00005~GNO:G43417UB.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 1 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Ser-177 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q96PD5-1, Ser-177, MOD:00002~GNO:G43417UB.


name: N-acetylmuramoyl-L-alanine amidase isoform h1 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PD5-1.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 5 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-181 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q96PD5-1, Thr-181, MOD:00005~GNO:G29068FM.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 2 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-151 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q96PD5-1, Thr-151, MOD:00005~GNO:G43417UB.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 10 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-193 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q96PD5-1, Thr-193, MOD:00005~GNO:G29068FM.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 7 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-181 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:Q96PD5-1, Thr-181, MOD:00005~GNO:G53434XO.


name: N-acetylmuramoyl-L-alanine amidase, signal peptide removed form (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has had the signal peptide removed. Example: UniProtKB:Q96PD5-1, 22-576.


name: N-acetylmuramoyl-L-alanine amidase N-glycosylated 1 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been N-glycosylated at the residue equivalent to Asn-367 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:Q96PD5-1, Asn-367, MOD:00160~GNO:G00912UN.


name: N-acetylmuramoyl-L-alanine amidase N-glycosylated 2 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been N-glycosylated at the residue equivalent to Asn-367 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:Q96PD5-1, Asn-367, MOD:00160~GNO:G42358LZ.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 4 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-168 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q96PD5-1, Thr-168, MOD:00005~GNO:G43417UB.


name: N-acetylmuramoyl-L-alanine amidase O-glycosylated 11 (human)

description: An N-acetylmuramoyl-L-alanine amidase (human) that has been O-glycosylated at the residue equivalent to Thr-193 of the amino acid sequence represented by UniProtKB:Q96PD5-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q96PD5-1, Thr-193, MOD:00005~GNO:G43417UB.


A steroid compound with a structure based on a 27-carbon (cholestane) skeleton.


A C27-steroid that is cholesterol carrying a hydroxy group at position 16S and 22S.


A 3beta-hydroxy-Delta(5)-steroid that is furostan carrying a double bond between positions 5-6 and hydroxy groups at positions 3beta and 22R.


A brassinosteroid that is 6-deoxo-28-norteasterone carrying an oxo group at position 6.


A cholestanoid that is cholest-4-en-3-one which has been substituted by hydroxy groups at the 7alpha, 12alpha, and 26 positions. It is an intermediate in bile acid metabolism.


An  oxysterol that is  cholesterol substituted by hydroxy groups at positions 17 and 20 (the 20R-stereoisomer).


A C27-steroid that is cholesterol carrying a hydroxy group at position 16S and an oxo group at position 22.


A deuterated compound that is cholesterol in which the hydrogens at positions 2, 2, 3, 4, 4 and 6 are replaced by deuterium.


A cholestanoid that is 7-dehydrocholesterol carrying an additional hydroxy substituent at position 24 (24S-stereoisomer).


A cholestanoid that is 7-dehydrocholesterol carrying an additional hydroxy substituent at position 25.


An oxysterol that is cholesterol substituted by hydroxy groups at positions 17 and 20 (the 20S-stereoisomer).


A cholestanoid that is desmosterol carrying an additional hydroxy susbstituent at position 26.


name: N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1 (human)

description: An N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1 that is encoded in the genome of human.


name: microtubule-associated serine/threonine-protein kinase 2 isoform h1 (human)

description: A microtubule-associated serine/threonine-protein kinase 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6P0Q8-1.


name: solute carrier family 2, facilitated glucose transporter member 2 isoform h2 (human)

description: A solute carrier family 2, facilitated glucose transporter member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11168-2.


name: pseudouridylate synthase TRUB2, mitochondrial isoform 1 (human)

description: A pseudouridylate synthase TRUB2, mitochondrial isoform 1 that is encoded in the genome of human.


name: cyclin-dependent kinase 8 isoform 1 (human)

description: A cyclin-dependent kinase 8 isoform 1 that is encoded in the genome of human.


name: serine/threonine-protein kinase tousled-like 1 isoform 1 (human)

description: A serine/threonine-protein kinase tousled-like 1 isoform 1 that is encoded in the genome of human.


fructosamine-3-kinase isoform 1 (human)

A fructosamine-3-kinase isoform 1 that is encoded in the genome of human.


protein PML sumoylated 1 (human)

A protein PML (human) that has been sumoylated on the residues at the positions equivalent to Lys-65, Lys-160, and Lys-490 of the amino acid sequence represented by UniProtKB:P29590-1. Example: UniProtKB:P29590-1, Lys-65/Lys-160/Lys-490, MOD:01149.


kininogen-1 O-glycosylated 16 (human)

A kininogen-1 (human) that has been O-glycosylated at the residue equivalent to Thr-137 of the amino acid sequence represented by UniProtKB:P01042-1, in which the glycan composition is represented by GlyTouCan:G17015OC. Example: UniProtKB:P01042-1, Thr-137, MOD:00005~GNO:G17015OC.


name: guided entry of tail-anchored proteins factor CAMLG methylated 1 (human)

description: A guided entry of tail-anchored proteins factor CAMLG (human) that has been methylated on the residue at the position equivalent to Cys-284 of the amino acid sequence represented by UniProtKB:P49069. UniProtKB:P49069, Cys-284, MOD:00660.


CD40 ligand N-glycosylated 12 (human)

A CD40 ligand (human) that has been N-glycosylated at the residue equivalent to Asn-240 of the amino acid sequence represented by UniProtKB:P29965-1, in which the glycan structure is represented by GlyTouCan:G55220VL. Example: UniProtKB:P29965-1, Asn-240, MOD:00160~GNO:G55220VL.


name: linker for activation of T-cells family member 1 isoform h3 (human)

description: A linker for activation of T-cells family member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43561-3.


name: linker for activation of T-cells family member 1

description: A protein that is a translation product of the human LAT gene or a 1:1 ortholog thereof.


name: linker for activation of T-cells family member 1 isoform h2 (human)

description: A linker for activation of T-cells family member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43561-2.


name: linker for activation of T-cells family member 1 isoform h4 (human)

description: A linker for activation of T-cells family member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43561-4.


name: linker for activation of T-cells family member 1 phosphorylated 2 (human)

description: A linker for activation of T-cells family member 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 200 and 220 of the amino acid sequence represented by UniProtKB:O43561. UniProtKB:O43561, Tyr-200/Tyr-220, MOD:00048.


name: linker for activation of T-cells family member 1 isoform h5 (human)

description: A linker for activation of T-cells family member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43561-5.


name: linker for activation of T-cells family member 1 phosphorylated 1 (human)

description: A linker for activation of T-cells family member 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 156, 161, 200, 220 and 255 of the amino acid sequence represented by UniProtKB:O43561. UniProtKB:O43561, Tyr-156/Tyr-161/Tyr-200/Tyr-220/Tyr-255, MOD:00048.


name: linker for activation of T-cells family member 1 isoform h1 (human)

description: A linker for activation of T-cells family member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43561-1.


name: linker for activation of T-cells family member 1 isoform h2 phosphorylated 1 (human)

description: A linker for activation of T-cells family member 1 isoform h2 (human) that has been phosphorylated on the residues at the positions equivalent to Tyr-127, Tyr-132, Tyr-171, Tyr-191, and Tyr-226 of the amino acid sequence represented by UniProtKB:O43561-2. UniProtKB:O43561-2, Tyr-127/Tyr-132/Tyr-171/Tyr-191/Tyr-226, MOD:00048.


name: serum paraoxonase/arylesterase 1 isoform 1 (human)

description: A serum paraoxonase/arylesterase 1 isoform 1 that is encoded in the genome of human.


name: diphthamide biosynthesis protein 3 isoform 1 (human)

description: A DPH3 isoform 1 that is encoded in the genome of human.


icosanoid

Any member of the group of signalling molecules arising from oxidation of the three C20 essential fatty acids (EFAs) icosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA).


18-hydroxythromboxane A2

A thromboxane A that is thromboxane A2 carrying an additional hydroxy substituent at position 18.


A (5Z,8Z,11Z)-14,15-dihydroxyicosatrienoic acid in which the two stereocentres at positions 14 and 15 both have R-configuration.


2,3,4,5-tetranor-thromboxane B1

A monocarboxylic acid that is thromboxane B1 which is lacking four methylenes in the carboxyalkyl chain. It is a urinary metabolite of thromboxane B2.


nonclassic icosanoid

Any biologically active signalling molecule made by oxygenation of C20 fatty acids other than the classic icosanoids (the leukotrienes and the prostanoids).


DHET

An icosanoid obtained by formal dihydroxylation across one of the double bonds of arachidonic acid.


11-dehydro-thromboxane B2

A thromboxane obtained by formal oxidation of the hemiacetal hydroxy function of thromboxane B2.


A HPETE that consists of (5Z,8Z,11Z,13E)-icosatetraenoic acid in which the hydroperoxy group is located at position 15.


An 8,9-EET in which the epoxy moiety has 8S,9R-configuration.


A (5Z,8Z,11Z)-14,15-dihydroxyicosatrienoic acid in which the two stereocentres at positions 14 and 15 both have S-configuration.


A HETE that is icosa-5,8,10,14-tetraenoic acid substituted by a hydroxy group at position 12. It is a metabolite of arachidonic acid.


trihydroxyicosatrienoic acid

A nonclassic icosanoid that consists of any icosatrienoic acid carrying three hydroxy substituents.


carbocyclic thromboxane A2

A member of the class of thromboxanes that is thromboxane A2 in which the bridging oxygen has been replaced by a methylene group.


thromboxane B3

A member of the class of thromboxanes B that is (5Z,13E,17Z)-thromboxa-5,13,17-trien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15.


A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 18.


An 8,9-EET in which the epoxy moiety has 8R,9S-configuration.


prostaglandin

Naturally occurring compounds derived from the parent C20 acid, prostanoic acid.


A 13-HETE in which the stereocentre at position 13 has S-configuration.


A 14,15-EET in which the epoxy moiety has 14R,15S-configuration.


EET

An icosanoid obtained by formal epoxidation of one of the double bonds of arachidonic acid.


HETE

Any monohydroxylated icosanoid having four double bonds.


icosenoic acid

An icosanoid comprising icosanoic acid having one C=C bond at any position.


The (5Z,8Z,10E,14Z)-stereoisomer of 12-HETE.


prostanoid

The family of natural prostaglandins and prostaglandin-like compounds including prostacyclins and thromboxanes.


thromboxane B1

A thromboxane B that is thromboxane B2 in which the double bond at position 5-6 has been reduced to a single bond.


A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 16.


An EET obtained by formal epoxidation of the 11,12-double bond of arachidonic acid.


A (5Z,8Z,14Z)-11,12-dihydroxyicosatrienoic acid in which the two stereocentres at positions 11 and 12 both have R-configuration.


A (5Z,11Z,14Z)-8,9-dihydroxyicosatrienoic acid in which the two stereocentres at positions 8 and 9 both have R-configuration.


A (5Z,11Z,14Z)-8,9-dihydroxyicosatrienoic acid in which the two stereocentres at positions 8 and 9 both have S-configuration.


18-hydroxycarbocyclic thromboxane A2

A member of the class of thromboxanes that is carbocyclic thromboxane A2 carrying an additional hydroxy substituent at position 18.


19-hydroxycarbocyclic thromboxane A2

A member of the class of thromboxanes that is carbocyclic thromboxane A2 carrying an additional hydroxy substituent at position 19.


leukotriene

Any icosanoid from that family of C20 polyunsaturated fatty acids and their derivatives generated by leukocytes from arachidonic acid, each member having four double bonds of which three are conjugated.


A 14,15-EET in which the epoxy moiety has 14S,15R-configuration.


HPETE

Mono-hydroperoxy (e)icosatetraenoic acids (HPETEs) are the primary products of lipoxygenase-catalysed oxygenation of arachidonic acid.


19-hydroxythromboxane A2

A thromboxane A that is thromboxane A2 carrying an additional hydroxy substituent at position 19.


A HETE that is (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid bearing a hydroxy substituent at position 15.


A (5Z,8Z,14Z)-11,12-dihydroxyicosatrienoic acid in which the two stereocentres at positions 11 and 12 both have S-configuration.


name: dual specificity protein phosphatase 13B isoform h5 (human)

description: A dual specificity protein phosphatase 13B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UII6-5.


Cervical Micropapillary Adenocarcinoma

description: A rare, invasive adenocarcinoma that arises from the cervix and is characterized by a micropapillary architecture.


calcitriol 25-O-(beta-D-glucuronide)

A steroid glucosiduronic acid that is calcitriol in which the hydroxy hydrogen at position 25 has been replaced by a beta-D-glucuronyl residue.


name: sodium/nucleoside cotransporter 1 isoform h2 (human)

description: A sodium/nucleoside cotransporter 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00337-2.


name: lactotransferrin, signal peptide removed form (human)

description: A lactotransferrin (human) that has had the signal peptide removed. UniProtKB:P02788, 20-710.


name: 1alpha,25-dihydroxy-2beta-(2-hydroxyethoxy)vitamin D3 / 1alpha,25-dihydroxy-2beta-(2-hydroxyethoxy)cholecalciferol


name: ATP-dependent RNA helicase DHX15 isoform 1 (human)

description: An ATP-dependent RNA helicase DHX15 isoform 1 that is encoded in the genome of human.


name: short transient receptor potential channel 6 isoform h1 (human)

description: A short transient receptor potential channel 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y210-1.


name: short transient receptor potential channel 6

description: A transient receptor potential cation channel TRPC3/6/7 that is a translation product of the human TRPC6 gene or a 1:1 ortholog thereof.