name: Extramedullary Disease in Multiple Myeloma Involving the Skin

description: Infiltration of the skin by malignant (clonal) plasma cells in patients with history of multiple myeloma.


DS Stage III Plasma Cell Myeloma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Multiple myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)


DS Stage I Plasma Cell Myeloma

description: Multiple myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)


DS Stage IIIA Multiple Myeloma

description: Durie/Salmon stage III multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


RISS Stage III Multiple Myeloma

description: Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


ISS Stage III Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)


DS Stage IB Multiple Myeloma

description: Durie/Salmon stage I multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: Extramedullary Disease in Multiple Myeloma Involving the Kidney

description: Infiltration of the kidney by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Multiple Myeloma with Hyperdiploidy

description: Multiple myeloma characterized by the presence of plasma cells in which the chromosomal number is greater than the normal diploid number.


ISS Stage I Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)


Multiple Myeloma Myeloma by DS Stage

description: A header term that refers to the staging of multiple myeloma according to the Durie/Salmon staging system.


victoria blue R

An iminium salt composed of 4-{[4-(dimethylamino)phenyl][4-(ethylamino)naphthalen-1-yl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio.


Finding by Site or System

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A term that refers to the classification of a clinical or laboratory finding according to the anatomic site or system that is involved.


Testosterone Excess

description: Abnormally high level of testosterone.


Melanocortin Pathway Defect

description: An abnormality in the biochemical pathway involving the melanocortins, a group of peptide hormones associated with anorexogenic signaling in the brain and hypothalamus.


Hormone Imbalance

description: An abnormal finding indicating that the level of a particular hormone is not within the expected normal values.


name: Congenital isolated adrenocorticotropic hormone deficiency

description: Adrenocorticotropic hormone (ACTH) deficiency due to mutation(s) in the TBX19 gene.


Adrenal Androgen Excess

description: Excessive secretion of the androgen hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Clinical manifestations may include virilization.


Endocrine System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the endocrine system.


name: Acquired Adrenocorticotropic Hormone Deficiency

description: Adrenocorticotropic hormone (ACTH) deficiency, the cause of which is not present at birth.


Ovarian Hyperandrogenism

description: Increased production of androgens by the ovaries.


Blood Pressure Finding

description: A test result that reports the diastolic and systolic pressure of the blood.


Cardiovascular System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the cardiovascular system.


COCARBOXYLASE

An organic chloride salt of thiamine(1+) diphosphate.


glucotriose

Any trisaccharide composed of 3 glucose moieties.


D-threonine

An optically active form of threonine having D-configuration.


An amido thiophene-2-carboxylic acid derivative used as an inhibitor of HCV (Hepatitis C Virus) RNA polymerase.


diphenyleneiodonium chloride

An organic chloride salt having dibenziodolium as the counterion.


name: Metastatic Endometrial Adenosquamous Carcinoma

description: Endometrial adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Metastatic Cervical Adenosquamous Carcinoma

description: A cervical adenosquamous carcinoma that has spread to another anatomic site.


name: Recurrent Cervical Adenosquamous Carcinoma

description: The reemergence of cervical adenosquamous carcinoma after a period of remission.


name: Recurrent Endometrial Adenosquamous Carcinoma

description: The reemergence of endometrial adenosquamous carcinoma after a period of remission.


biotins

Compounds containing a biotin (5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid) skeleton.


A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.


GDP-beta-L-fucose

A GDP-L-fucose in which the anomeric oxygen is on the same side of the fucose ring as the methyl substituent.


Cervical Squamotransitional Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures with fibrovascular cores. It is covered with multiple layers of atypical cells that resemble cervical intraepithelial neoplasia 3.


hydrocortisone phosphate

A steroid phosphate that is the 21-O-phospho derivative of cortisol.


prednisolone sodium phosphate

A synthetic glucocorticoid resulting from the formal condensation of the 21-hydroxy group of prednisolone with one of the hydroxy groups of phosphoric acid. It is a prodrug for prednisolone that is activated in vivo by phosphatases.


betamethasone phosphate

A steroid phosphate that is the 21-O-phospho derivative of betamethasone.


dexamethasone phosphate

A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.


name: Recurrent Endometrial Undifferentiated Carcinoma

description: The reemergence of endometrial undifferentiated carcinoma after a period of remission.


name: Metastatic Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that has spread from its original site of growth to another anatomic site.


name: Refractory Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that is resistant to treatment.


name: 6,6-dimethyl-4-oxo-3-(phenylmethylthio)-5,7-dihydro-2-benzothiophene-1-carboxylic acid ethyl ester


LURASIDONE HYDROCHLORIDE

A hydrochloride obtained by reaction of lurasidone with one equivalent of hydrochloric acid. An atypical antipsychotic agent used for the treatment of schizophrenia.


phenosafranine

An organic chloride salt having 3,7-diamino-5-phenylphenazin-5-ium as the counterion. It is commonly used for staining Gram negative bacteria red in smears to contrast with the blue Gram positive organisms.


Tyr-Tyr

Tyrosyltyrosine in which each tyrosine residue has L-configuration.


PENTAERYTHRITYL DINITRATE

A pentaerythritol nitrate in which two of the hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester.


inorganic peroxide

Compounds of structure ROOR' in which R and R' are inorganic groups.


iminium ion

Cations of structure R2C=N(+)R2.


name: Stage IVA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Cervical Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant neoplasm with nerve sheath differentiation arising from the cervix.


name: Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IIIC Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Uterine Corpus Low Grade Endometrial Stromal Sarcoma

description: A rare, indolent, invasive mesenchymal tumor that arises from the endometrial stroma. It is characterized by the presence of a plexiform vasculature, infrequent mitoses, and insignificant cytologic atypia. Late recurrences may occur.


name: Stage IIIA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage IVB Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Uterine Corpus Endometrial Stromal Sarcoma by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus endometrial stroma sarcoma according to the American Joint Committee on Cancer, 8th edition.


Cervical Angiosarcoma

description: A highly aggressive malignant vascular neoplasm that arises from the cervix and shows endothelial cell differentiation.


name: Stage II Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Endocervical Undifferentiated Sarcoma

description: A high grade undifferentiated sarcoma that arises from the endocervix.


name: Stage IV Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Uterine corpus endometrial stroma sarcoma with tumor invading bladder or rectum. M0: No distant metastasis. M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


Malignant Cervical Soft Tissue Neoplasm

description: A rare malignant mesenchymal neoplasm that arises from the cervix.


AIDS-Related Cervical Kaposi Sarcoma

description: A Kaposi sarcoma arising from the cervix in patients who are infected with the human immunodeficiency virus.


name: Stage IA Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus, measuring 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Stage III Uterine Corpus Endometrial Stromal Sarcoma AJCC v8

description: Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus endometrial stroma sarcoma with tumor limited to the uterus. T2: Uterine corpus endometrial stroma sarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus endometrial stroma sarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Cervical Low Grade Endometrioid Stromal Sarcoma

description: A very rare sarcoma that arises from the cervix and is characterized by the presence of cells that resemble endometrial stromal cells.


glucose

An aldohexose used as a source of energy and metabolic intermediate.


alkane

An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms.


octadecane

A straight-chain alkane carrying 18 carbon atoms.


long-chain alkane

Any alkane having a chain length of at least 13 carbon atoms.


DULOXETINE HYDROCHLORIDE

A duloxetine hydrochloride in which the duloxetine moiety has S configuration.


ROPIVACAINE HYDROCHLORIDE

The anhydrous form of (S)-ropivacaine hydrochloride.


(R)-bromazine

The (R)-enantiomer of bromazine.


straight-chain fatty acid

Any fatty acid whose skeletal carbon atoms form an unbranched open chain.


hydroxypalmitic acid

A hydroxy fatty acid that is palmitic (hexadecanoic) acid substituted with one hydroxy group.


linolenic acid

A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.


vaccenic acid

An octadecenoic acid having a double bond at position 11; and which can occur in cis- or trans- configurations.


octadecadienoic acid

Any straight-chain, C18 polyunsaturated fatty acid having two C=C double bonds.


conjugated linoleic acid

An octadecadienoic acid having a system of two conjugated double bonds at any position.


docosapentaenoic acid

Any straight-chain, C22 fatty acid having five C=C double bonds.


2-tetradecenoic acid

A tetradecenoic acid having its double bond in the 2-position.


2-hydroxyhexadecanoic acid

A 2-hydroxy fatty acid comprising a C16 straight chain carrying a hydroxy substituent at position 2.


octadecatrienoic acid

Any trienoic fatty acid having eighteen carbons.


fatty acid 20:3

Any trienoic fatty acid with twenty carbons.


hexadecadienoic acid

Any straight-chain, C16 polyunsaturated fatty acid containing two C=C double bonds (position and geometry not specified).


3-hydroxypalmitic acid

A long-chain fatty acid that is the 3-hydroxy derivative of palmitic acid.


2-decenoic acid

A decenoic acid having its double bond in position 2.


butenoic acid

Any C4, straight-chain fatty acid containing one double bond.


(5Z,7E,9E,14Z,17Z)-icosapentaenoic acid

The (5Z,7E,9E,14Z,17Z)-isomer of icosapentaenoic acid.


hexadec-9-enoic acid

A hexadecenoic acid in which the double bond is located at position 9.


pentenoic acid

Any C5, straight-chain, monounsaturated fatty acid.


tetracosenoic acid

Any C24 monounsaturated fatty acid containing one double bond.


The (9Z,11E,13E,15Z)-isomer of parinaric acid.


docosenoic acid

A C22, monounsaturated fatty acid carrying a C=C double bond at any position.


tetradecenoic acid

Any C14 straight-chain monounsaturated fatty acid having one C=C double bond.


hexadecenoic acid

A C16 straight-chain monounsaturated fatty acid having one C=C double bond.


octadecatetraenoic acid

A polyunsaturated fatty acid whose structure contains double bonds at any four positions of an 18-carbon straight chain.


5,8,11-eicosatrienoic acid

An icosatrienoic acid with three bonds at positions 5, 8 and 11.


decenoic acid

Any C10 monounsaturated fatty acid having a double bond in the carbon backbone.


trans-parinaric acid

The all-trans- isomer of parinaric acid.


2-butenoic acid

A butenoic acid having the double bond at position C-2.


docosatetraenoic acid

Any straight-chain, C22 fatty acid having four C=C double bonds.


Head and Neck Disorder

description: A non-neoplastic or neoplastic disorder that affects the anatomic structures of the head and neck region.  This category includes inflammatory disorders, benign neoplasms, precancerous conditions, and malignant neoplasms.


Congenital thyroid disorder

description: A thyroid gland disorder present at birth. It includes thyroid gland aplasia and thyroid gland hypoplasia, both result in hypothyroidism.


Disorder of neck

description: A non-neoplastic or neoplastic disorder that affects the anatomic structures of the neck region.  This category includes disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


Non-Neoplastic Thyroid Gland Disorder

description: A non-neoplastic disorder that affects the thyroid gland.  Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, and thyroid gland abscess.


Non-Neoplastic Neck Disorder

description: A non-neoplastic disorder that affects the anatomic structures of the neck region.  This category includes non-neoplastic disorders of the pharynx, larynx, thyroid gland, and parathyroid gland.


Non-Neoplastic Head and Neck Disorder

description: A non-neoplastic disorder that affects the anatomic structures of the head and neck region.


nabiximols

A diverse group of pharmacologically active secondary metabolite characteristic to Cannabis plant as well as produced naturally in the body by humans and animals. Cannabinoids contain oxygen as a part of the heterocyclic ring or in the form of various functional groups. They are subdivided on the basis of their origin.


phytocannabinoid

A class of cannabinoid which are C21 terpenophenolic compounds isolated primarily from Cannabis sativa.


endocannabinoid

A class of cannabinoids present in mammalian biological fluids and tissues that activate cannabinoid receptors.


oxooctadecadienoic acid

An oxo fatty acid that is obtained by oxidation of the allylic hydroxy group of any hydroxyoctadecadienoic acid during its metabolism.


13-oxo-9,11-octadecadienoic acid

An oxooctadecadienoic acid that is 9,11-octadecadienoic acid in which the oxo group is located at position 13.


D-lysine hydrochloride

The hydrochloride salt of D-lysine.


A quinolin-4-one having methyl and hydroxy substituents at the 2- and 3-positions respectively.


2-methylbutanedioic acid

A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group.


gamma-lactone

A lactone having a five-membered lactone ring.


butenolide

A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.


A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one in which all or the hydrogens attached to the benzene ring are replaced by chlorines. A fungicide used for the control of rice blast, it is not approved for use within the European Union.


The 2-chloro derivative of cis-4-carboxymethylenebut-2-en-1,4-olide.


decatromicin A

A carbohydrate-containing antibiotic isolated from Actinomadura sp. MK73-NF4. It specifically inhibits the growth of gram-positive bacteria including multi-drug resistant strains such as Staphylococcus aureus MS9610 and menthicilin-resistant S.aureus (MRSA).


The trans-isomer of 2-chloro-4-carboxymethylenebut-2-en-1,4-olide.


teniposide

A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.


vitamin C

Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.


sarmentologenin

A steroid lactone that is card-20(22)-enolide substituted by hydroxy groups at positions 3, 5, 11, 14 and 19.


Any gamma-lactone having the lactone moiety derived from 4-hydroxybutanoic acid.


TRIPROLIDINE HYDROCHLORIDE

A hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. Its monohydrate is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.


Halogenated cyanine compound that binds nucleic acids.


A C21-steroid that is cortisone in which the 21-hydroxy group has been oxidised to the corresponding aldehyde.


A C21-steroid that is cortisol in which the 21-hydroxy group has been oxidised to the corresponding aldehyde.


MEPERIDINE HYDROCHLORIDE

The hydrochloride salt of pethidine. An analgesic used for the treatment of postoperative and labour pain.


quercetin O-glucoside

A quercetin O-glycoside that is an O-glucosylated derivative of quercetin.


N-tetracosenoylsphingosine

An acylsphingosine in which the acyl moiety contains 24 carbons and 1 double bond.


diarylmethane

Any compound containing two aryl groups connected by a single C atom.


A diarylmethane in which the two aryl groups are specified as 5-methylfuran-2-yl and pyrrol-3-yl.


ESMETHADONE

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder.


(-)-methadone

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine.


multi-methyl-branched fatty acyl-CoA

A branched-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any multi-methyl-branched fatty acid.


Pristanoyl-CoA in which C-2 of the pristanoyl group has R-configuration.


Pristanoyl-CoA in which C-2 of the pristanoyl group has S-configuration.


AMANTADINE HYDROCHLORIDE

A hydrochloride obtained by combining amantadine and hydrochloric acid in equimolar amounts.


bromomethanes

A halomethane that is methane in which one or more hydrogens has been replaced by bromine.


FLUOROBENZENE

Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.


copper(I) chloride

An inorganic chloride of copper in which the metal is in the +1 oxidation state.


cupric chloride

An inorganic chloride of copper in which the metal is in the +2 oxidation state.


Stage IIIB Cervical Cancer AJCC v9

description: Stage IIIB includes: T3b, N0, M0. T3b: Tumor extending to pelvic wall and/or causing hydronephrosis or nonfunctioning kidney (unless known to be due to another cause). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Refractory Endometrial Mucinous Adenocarcinoma

description: Endometrial mucinous adenocarcinoma that is resistant to treatment.


name: Refractory Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that is resistant to treatment.


name: Refractory Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma that is resistant to treatment.


name: Metastatic Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


Stage I Cervical Cancer FIGO 2009

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2009)


Infrequent Neoplasm

description: A neoplasm that is uncommon.


Cervical Mucoepidermoid Carcinoma

description: A rare carcinoma that arises from the cervix. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type.


Pure Cutaneous Mastocytosis

description: Mastocytosis that manifests with pure cutaneous involvement.


Stage IIB Cervical Cancer FIGO 2018

description: Cervical carcinoma with parametrial involvement but not up to the pelvic wall. (FIGO 2018)


Stage IIB Cervical Cancer FIGO 2009

description: Cervical carcinoma with parametrial invasion. (FIGO 2009)


name: Cervical Invasive Stratified Mucinous Adenocarcinoma

description: A rare, distinct form of invasive cervical mucinous adenocarcinoma associated with human papillomavirus infection. It is characterized by the presence of stratiﬁed, immature epithelial cells containing varying quantities of intracytoplasmic mucin.


Undifferentiated schizophrenia

description: A subtype of schizophrenia in which the individual exhibits the characteristic symptoms of schizophrenia but the overall picture is not one of catatonic type, paranoid type, or disorganized type schizophrenia.


Stage I Cervical Cancer AJCC v9

description: Stage I includes: T1, N0, M0. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage II Cervical Cancer AJCC v7

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: High Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting more than 50% solid non-glandular, non-squamous growth.


name: Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

description: A cervical squamous cell carcinoma associated with human papillomavirus infection.


Stage III Cervical Cancer FIGO 2018

description: Cervical carcinoma that involves the lower third of the vagina and/or extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney and/or involves pelvic and/or para-aortic lymph nodes. (FIGO 2018)


Stage IB2 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma equal or more than 2 cm and less than 4 cm in greatest dimension. (FIGO 2018)


Stage IVA Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to adjacent pelvic organs. (FIGO 2018)


name: Metastatic Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Human Papillomavirus-Related Cervical Adenocarcinoma In Situ

description: Cervical adenocarcinoma in situ associated with human papillomavirus infection.


Stage IIIC2 Cervical Cancer FIGO 2018

description: Cervical carcinoma with para-aortic lymph node metastasis. (FIGO 2018)


Malignant hepatobiliary neoplasms

description: A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder.  Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


name: Recurrent High Grade Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial high-grade endometrioid adenocarcinoma after a period of remission.


High Grade Endometrial Carcinoma

description: A group of aggressive endometrial carcinomas with high-grade histological features. It includes high grade endometrial endometrioid adenocarcinoma, endometrial clear cell adenocarcinoma, endometrial serous adenocarcinoma, and endometrial undifferentiated carcinoma.


name: Stage III Cervical Cancer AJCC v6 and v7

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T1, N1, M0), (T2, N1, M0), (T3a, N1, M0), (T3b, Any N, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non functioning kidney.  N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


undifferentiated carcinoma of cervix

description: A rare carcinoma that arises from the cervix and is characterized by the lack of specific cellular differentiation.


Stage IV Cervical Cancer AJCC v8

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


name: Endometrial Mucinous Adenocarcinoma, Intestinal-Type

description: A rare mucinous adenocarcinoma arising from intestinal metaplasia of the endometrium.


Stage II Cervical Cancer AJCC v8

description: Stage II includes: T2, Any N, M0. T2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IA Cervical Cancer AJCC v8

description: Stage IA includes: T1a, Any N, M0. T1a: Tumor diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. M0: No distant metastasis. (AJCC 8th Ed.)


Mitochondrial enzyme deficiency

description: A constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.


Stage IIIC1 Cervical Cancer AJCC v9

description: Stage IIIC1 includes: TX, T0, T1-3, N1, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIA Cervical Cancer AJCC v7

description: Stage IIA includes: IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0).  T2a: Tumor without parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)


Stage IB Cervical Cancer AJCC v8

description: Stage IB includes: T1b, Any N, M0. T1b: Tumor with clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. It includes all macroscopically visible lesions, even those with superficial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


Cervical Cancer by FIGO Stage 2009

description: A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2009.


name: Non-Neoplastic Central Nervous System Disorder


Stage IB2 Cervical Cancer AJCC v8

description: Stage IB2 includes: T1b2, Any N, M0. T1b2: Tumor with clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Cervical Cancer AJCC v6

description: Tumor without parametrial invasion.


name: Metastatic Malignant Neoplasm to the Cervix

description: A malignant neoplasm that has spread to the cervix from another anatomic site.


Stage IB1 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma with equal or more than 5 mm depth of stromal invasion, and less than 2 cm in greatest dimension. (FIGO 2018)


name: Recurrent Endometrial Squamous Cell Carcinoma

description: The reemergence of endometrial squamous cell carcinoma after a period of remission.


name: POLE-Ultramutated Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene that result in an ultra-mutated tumor phenotype.


Cervical Adenocarcinoma In Situ

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Non-Neoplastic Retroperitoneal Disorder

description: A non-neoplastic disorder that affects the retroperitoneum.


Cystic fibrosis pulmonary exacerbation

description: An acute episode of worsening pulmonary symptoms related to cystic fibrosis.


name: Non-Neoplastic Genitourinary System Disorder

description: A non-neoplastic disorder that affects the genitourinary system.


Stage IIIA Cervical Cancer FIGO 2009

description: Cervical carcinoma involving lower one-third of the vagina. (FIGO 2009)


Rare Non-Neoplastic Disorder

description: A non-neoplastic disorder that is uncommon.


Stage IA1 Cervical Cancer AJCC v8

description: Stage IA1 includes: T1a1, Any N, M0. T1a1: Invasive cervical carcinoma with measured stromal invasion of 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. M0: No distant metastasis. (AJCC 8th Ed.)


name: Human Papillomavirus-Independent Cervical Squamous Cell Carcinoma

description: A cervical squamous cell carcinoma not associated with human papillomavirus infection.


name: p53-Mutant Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the presence of p53 gene mutations.


mCode Neoplastic Disease/Finding

description: Terminology related to neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Non-Neoplastic Endocrine Disorder

description: A non-neoplastic disorder that affects the endocrine system.  Representative examples include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency.


name: Metastatic Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that has spread from its original site of growth to another anatomic site.


Non-Neoplastic Vascular Disorder

description: A term that includes all non-neoplastic vascular disorders.


mCode Disease/Finding

description: Terminology related to diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


Early Rheumatoid Arthritis

description: Recent diagnosis of rheumatoid arthritis (usually within one to two years of onset) during which treatment may be more effective and possibly improve the disease course.


B-Cell Lymphoproliferative Disorder

description: A non-neoplastic or neoplastic proliferation of B-lymphocytes.


Stage II Cervical Cancer FIGO 2009

description: Cervical carcinoma invading beyond the uterus but not extending onto the lower third of the vagina or to the pelvic wall. (FIGO 2009)


name: Microsatellite Stable Endometrial Carcinoma

description: Endometrial carcinoma characterized by the absence of microsatellite instability.


Abnormal Laboratory Test Result

description: A laboratory test result that falls outside of the normal, acceptable range.


Enzyme Deficiency

description: A finding in which there is a subnormal amount of an enzyme. Enzymes are proteins that are necessary in certain catabolic processes.


Stage IV Cervical Cancer FIGO 2009

description: Cervical carcinoma involving adjacent and distant organs. (FIGO 2009)


name: Non-Neoplastic Peritoneal and Retroperitoneal Disorder

description: A non-neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Stage IB Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth. (FIGO 2009)


name: Recurrent Endometrial Mixed Cell Adenocarcinoma

description: The reemergence of endometrial mixed cell adenocarcinoma after a period of remission.


Refractory Endometrial Adenocarcinoma

description: Endometrial adenocarcinoma that is resistant to treatment.


Non-Neoplastic Soft Tissue Disorder

description: A non-neoplastic disorder that affects the soft tissue.


name: Locally Advanced Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Recurrent Endometrial Mucinous Adenocarcinoma

description: The reemergence of endometrial mucinous adenocarcinoma after a period of remission.


Stage III Cervical Cancer FIGO 2009

description: Cervical carcinoma involving lower vagina, pelvic sidewall, and ureters. (FIGO 2009)


Stage IB2 Cervical Cancer AJCC v9

description: Stage IB2 includes: T1b2, N0, M0. T1b2: Tumor measuring more than 2 cm and equal or less than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIIA Cervical Cancer AJCC v9

description: Stage IIIA includes: T3a, N0, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring equal or less than 3 mm in depth. (FIGO 2009)


Stage IB Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma with measured deepest invasion equal or more than 5 mm (greater than Stage IA), lesion limited to the cervix uteri. (FIGO 2018)


Polyarticular Still Disease

description: Juvenile rheumatoid arthritis affecting multiple joints, usually symmetrically. It may be associated with low grade fever, anemia, and weight loss. Patients usually test negative for rheumatoid factor.


Stage IIA2 Cervical Cancer AJCC v7

description: Stage IIA2 includes: T2a2, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Endometrial Large Cell Neuroendocrine Carcinoma

description: A high grade neuroendocrine carcinoma that arises from the endometrium. It is composed of large polygonal cells arranged in well-demarcated nests, trabeculae or cords with peripheral palisading.


name: Cervical Squamous Cell Carcinoma In Situ

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


Nerve palsy

description: Paralysis that is caused by damage to a nerve.


Stage IV Cervical Cancer AJCC v9

description: Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


name: Human Papillomavirus-Independent Cervical Adenocarcinoma

description: Cervical adenocarcinoma not associated with human papillomavirus infection.


Stage IA Cervical Cancer AJCC v9

description: Stage IA includes: T1a, N0, M0. T1a: Tumor that can be diagnosed only by microscopy with maximum depth of invasion equal or less than 5 mm. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIA2 Cervical Cancer AJCC v9

description: Stage IIA2 includes: T2a2, N0, M0. T2a2: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Respiratory, thoracic and mediastinal disorders

description: A non-neoplastic or neoplastic disorder that affects the respiratory system or the thoracic organs.


Stage IIA1 Cervical Cancer AJCC v7

description: Stage IIA1 includes: T2a1, N0, M0.  Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion.  T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Cerebral Adrenoleukodystrophy

description: A subtype of adrenoleukodystrophy (ALD) occurring in approximately 40 percent of boys with ALD, primarily affecting the cerebrum, resulting in rapidly declining neurocognitive function and in most patients, premature death.


Congenital Systemic Disorder

description: An inherited disorder that presents with systemic manifestations.


name: Refractory Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma, not otherwise specified, that is resistant to treatment.


Congenital Adrenal Gland Disorder

description: A genetic disorder that affects the adrenal gland.  It includes adrenal gland hyperplasia and adrenal gland hypoplasia.


Schizophrenia, Childhood

description: Schizophrenia occurring in childhood.


Retroperitoneal disorder

description: A non-neoplastic or neoplastic disorder that affects the retroperitoneum.


Schizophrenia, Disorganized

description: A subtype of schizophrenia characterized by disorganized speech, disorganized behavior, and a flat or inappropriate affect; associated features include grimacing, mannerisms, and other oddities of behavior. Criteria for the catatonic type of schizophrenia are not met.


name: Cervical Adenocarcinoma, Not Otherwise Specified

description: A cervical adenocarcinoma that cannot be classified by WHO criteria or International Endocervical Adenocarcinoma Criteria and Classification (IECC).


Thoracic Diseases

description: A non-neoplastic or neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity.  Representative examples include pleural infection, mediastinitis, thymoma, mediastinal lymphoma, and pleural mesothelioma.


Infiltrating Cervical Carcinoma

description: A carcinoma that arises from the cervix and invades into the stromal tissue.


Stage IB3 Cervical Cancer AJCC v9

description: Stage IB3 includes: T1b3, N0, M0. T1b3: Tumor measuring more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Metastatic Endometrial Serous Adenocarcinoma

description: An endometrial serous adenocarcinoma that has spread to other anatomic sites.


Male Reproductive System Carcinoma

description: A malignant neoplasm that arises from the epithelium of any part of the male reproductive system. Representative examples include prostate carcinoma and penile carcinoma.


Stage III Cervical Cancer AJCC v8

description: Stage III includes: T3, Any N, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIIC2 Cervical Cancer AJCC v9

description: Stage IIIC2 includes: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Human Papillomavirus-Related Cervical Adenocarcinoma

description: A cervical adenocarcinoma associated with the presence of human papillomavirus infection.


description: An endometrial carcinoma that has a documented response to platinum-based chemotherapy.


Stage IB1 Cervical Cancer AJCC v9

description: Stage IB1 includes: T1b1, N0, M0. T1b1: Tumor measuring more than 5 mm in depth and equal or less than 2 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Abnormal Blood Chemistry and Hematology Test Result

description: A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values.


Rare Diseases

description: A non-neoplastic or neoplastic disorder that is uncommon.


Vulvar Dysplastic Melanocytic Nevus

description: A rare, elevated and pigmented, compound or junctional nevus that arises from the vulva. It affects women in their reproductive years and may be associated with the presence of dysplastic nevi in other anatomic areas. It is characterized by the presence of epithelioid or spindle-shaped melanocytes exhibiting nuclear pleomorphism and prominent nucleoli.


Stage IIB Cervical Cancer AJCC v9

description: Stage IIB includes: T2b, N0, M0. T2b: Tumor with parametrial invasion but not up to the pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage II Cervical Cancer AJCC v6

description: Stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIB (T2b, N0, M0). T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Type I Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to endometrioid adenocarcinoma and mucinous adenocarcinoma.


name: Peritoneal and retroperitoneal disorders

description: A non-neoplastic or neoplastic disorder that affects the peritoneum and/or retroperitoneum.


Stage IIB Cervical Cancer AJCC v8

description: Stage IIB includes: T2b, Any N, M0. T2b: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina with parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


name: Non-Neoplastic Digestive System Disorder

description: A non-neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. Representative examples include infections, ulcers, cirrhosis, and diverticulosis.


name: Stage IIIA Cervical Cancer AJCC v6 and v7

description: Stage IIIA includes: T3a, N0, M0.  T3a: Tumor involves lower third of vagina, no extension to pelvic wall.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


name: Recurrent Malignant Endocervical Neoplasm

description: The reemergence of a malignant neoplasm of the endocervix after a period of remission.


name: Recurrent Cervical Squamous Cell Carcinoma

description: The reemergence of cervical squamous cell carcinoma after a period of remission.


Cervical Yolk Sac Tumor

description: A yolk sac tumor that arises from the cervix. Patients present with abnormal vaginal bleeding and a polypoid, friable mass, protruding into the vagina.


Mental disorder in childhood

description: A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence.


name: FIGO Grade 2 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains 6-50% non-squamous solid areas.


name: Endometrial Mucinous Adenocarcinoma, Gastric-Type

description: A rare mucinous adenocarcinoma arising from gastric metaplasia of the endometrium.


Stage IB1 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and equal or less than 4 cm in maximum diameter. (FIGO 2009)


Stage IVB Cervical Cancer AJCC v9

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis including inguinal lymph nodes, lung, liver, bone, or intraperitoneal metastases. Metastases to pelvic or paraaortic lymph nodes, or vagina are excluded. (from AJCC 9th Ed.)


Unresectable Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is not amenable to surgical resection.


name: Recurrent Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial endometrioid adenocarcinoma after a period of remission.


Stage IB1 Cervical Cancer

description: Stage IB1 includes: T1b1, N0, M0.  T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Cervical Cancer by AJCC v8 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 8th edition.


Stage IIIC Cervical Cancer AJCC v9

description: Stage IIIC includes: IIIC1: TX, T0, T1-3, N1, M0; IIIC2: TX, T0, T1-3, N2, M0. TX: Primary tumor cannot be assessed. T0: No evidence of primary tumor. T1: Tumor strictly confined to the cervix (extension to corpus should be disregarded). T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N1: Tumor with regional lymph node metastasis to pelvic lymph nodes only. N2: Tumor with regional lymph node metastasis to para-aortic lymph nodes with or without positive pelvic lymph nodes.  M0: No distant metastasis. (from AJCC 9th Ed.)


Locally Advanced Cervical Carcinoma

description: A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Stage IIB Cervical Cancer AJCC v6 and v7

description: Stage IIB includes: T2b, N0, M0.  T2b: Tumor with parametrial invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Stage IIA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and measuring more than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Brain Disorder

description: A non-neoplastic disorder that affects the brain. Representative examples include cerebrovascular disorder, hydrocephalus, and encephalitis.


name: Refractory Endometrial Serous Adenocarcinoma

description: Endometrial serous adenocarcinoma that is resistant to treatment.


name: Recurrent Endometrial Dedifferentiated Carcinoma

description: The reemergence of endometrial dedifferentiated carcinoma after a period of remission.


Recurrent Endometrial Cancer

description: The reemergence of endometrial carcinoma after a period of remission.


name: Metastatic Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread to another anatomic site.


Prostatic Basal Cell Hyperplasia

description: A type of prostatic hyperplasia.  It is characterized by the presence of nodules of dark basal cells around residual prostatic secretory cells.


Stage IA1 Cervical Cancer AJCC v9

description: Stage IA1 includes: T1a1, N0, M0. T1a1: Tumor with measured stromal invasion equal or less than 3 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Connective and Soft Tissue Disorder

description: A non-neoplastic or neoplastic disorder that affects the connective and soft tissue.


name: Utricle-Associated Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the area of the utricle.


Biliary System Disorder

description: A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.


Early Stage Cervical Carcinoma

description: A stage term that refers to cervical carcinoma stages IA, IB, and IIA.


name: Unresectable Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is not amenable to surgical resection.


name: Prostatic Clear Cell Cribriform Hyperplasia

description: A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm.


name: Recurrent Endometrial Clear Cell Adenocarcinoma

description: The reemergence of endometrial clear cell adenocarcinoma after a period of remission.


CTRP Clinical Finding

description: A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials.


name: AIDS-Related Malignant Cervical Neoplasm

description: A malignant neoplasm that arises from the cervix in a patient with acquired immunodeficiency syndrome. This category includes cervical carcinoma, Kaposi sarcoma, and non-Hodgkin lymphoma.


Stage IIA2 Cervical Cancer AJCC v8

description: Stage IIA2 includes: T2a2, Any N, M0. T2a2: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion more than 4.0 cm in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Cervical Cancer AJCC v8

description: Stage I includes: T1, Any N, M0. T1: Tumor confined to uterus (extension to corpus should be disregarded). M0: No distant metastasis. (AJCC 8th Ed.)


name: No Specific Molecular Profile Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma characterized by the absence of POLE gene mutations, mismatch repair (MMR) deficiency, and p53 gene mutations.


Metastatic Endometrial Carcinoma

description: A carcinoma that arises from the endometrium and has metastasized to another anatomic site.


mCode Non-Neoplastic Disease/Finding

description: Terminology related to non-neoplastic diseases and findings that was developed to support the efforts of Minimal Common Oncology Data Elements (mCode), a data standard designed to increase high-quality data for all cancer types.


name: Refractory Endometrial Transitional Cell Carcinoma

description: Endometrial transitional cell carcinoma that is resistant to treatment.


Stage IIIC Cervical Cancer FIGO 2018

description: Cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations). (FIGO 2018)


Stage II Cervical Cancer FIGO 2018

description: The cervical carcinoma invades beyond the uterus, but has not extended onto the lower third of the vagina or to the pelvic wall. (FIGO 2018)


Non-Neoplastic Pancreatic Disorder

description: A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency.


name: Refractory Endometrial Squamous Cell Carcinoma


Sign or Symptom

description: Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom).


Paraphrenia

description: A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner.


name: 21-hydroxylase deficiency - simple virilizing

description: A classic form of congenital adrenal hyperplasia that is characterized by severe 21-hydroxylase deficiency, resulting in glucocorticoid and mineralocorticoid deficiency, but without clinically significant salt wasting, and with androgen excess, which causes virilization in female infants.


Recurrent Cervical Adenocarcinoma

description: The reemergence of cervical adenocarcinoma after a period of remission.


Stage IIIB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving the pelvic sidewall. (FIGO 2009)


Non-Neoplastic Eye Disorder

description: A non-neoplastic disorder that affects the eye.


Blood and lymphatic system disorders

description: A non-neoplastic or neoplastic disorder that affects the hematopoietic and lymphatic system.


Metastatic Cervical Carcinoma

description: A carcinoma of the cervix that has spread to another anatomic site.


Non-Neoplastic Bone Disorder

description: A non-neoplastic disorder that affects the bone or articular cartilage.


name: Non-Neoplastic Endocrine Pancreas Disorder

description: A non-neoplastic disorder that affects the endocrine pancreas.


name: Non-Neoplastic Disorder by Special Category


Hereditary Malignant Neoplasm

description: Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Monogenic Hyperinsulinism

description: A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Cervix carcinoma recurrent

description: The reemergence of cervical carcinoma after a period of remission.


name: Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

description: A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


Neuroendocrine cervical carcinoma

description: A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Genitourinary System Neoplasm

description: A benign or malignant neoplasm that affects the genitourinary system.


Stage IB Cervical Cancer AJCC v6 and v7

description: Stage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Metastatic Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread to another anatomic site.


Gastrointestinal disorder congenital

description: An abnormality of the digestive system that is present at birth or detected in the neonatal period.


name: Refractory Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is resistant to treatment.


Other Finding

description: An additional finding not previously noted.


Stage IVA Cervical Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


name: Human Papillomavirus-Independent Cervical Adenocarcinoma In Situ

description: Cervical adenocarcinoma in situ not associated with human papillomavirus infection.


name: Endometrioid adenocarcinoma, ciliated cell variant

description: An endometrioid adenocarcinoma arising from the endometrium, in which ciliated cells line the majority of the malignant glands.


Cervical Cancer by AJCC v7 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 7th edition.


Stage IIA1 Cervical Cancer AJCC v9

description: Stage IIA1 includes: T2a1, N0, M0. T2a1: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IV Cervical Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0); IVB (Any T, Any N, MI). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M1: Distant metastasis. (AJCC 6th and 7th eds.)


Endometrial Neuroendocrine Carcinoma

description: A small cell or large cell neuroendocrine carcinoma arising from the endometrium.


name: Refractory Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that is resistant to treatment.


name: FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


Stage IA2 Cervical Cancer AJCC v9

description: Stage IA2 includes: T1a2, N0, M0. T1a2: Tumor with measured stromal invasion of more than 3.0 mm and equal or less than 5.0 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Mental and Behavioral Signs and Symptoms

description: Clinical evidence of disease resulting from mental and/or behavioral dysfunction.


Stage II Cervical Cancer AJCC v9

description: Stage II includes: T2, N0, M0. T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage IIA Cervical Cancer AJCC v9

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Stage IVA Cervical Cancer AJCC v6 and v7

description: Stage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)


Immune System and Related Disorders

description: A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


name: Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

description: A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component.


Stage IIA Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina. (FIGO 2009)


Non-Neoplastic Disorder

description: Any disorder other than abnormal tissue growth resulting from uncontrolled cell proliferation.


Stage IA2 Cervical Cancer AJCC v8

description: Stage IA2 includes: T1a2, Any N, M0. T1a2: Invasive cervical carcinoma with measured stromal invasion of more than 3.0 mm and not more than 5.0 mm, with a horizontal spread of 7.0 mm or less. M0: No distant metastasis. (AJCC 8th Ed.)


name: Metastatic Endometrial Endometrioid Adenocarcinoma

description: An endometrial endometrioid adenocarcinoma that has spread to other anatomic sites.


Genitourinary Cancer

description: A primary or metastatic malignant neoplasm that affects the genitourinary system.


name: Serous Endometrial Intraepithelial Carcinoma

description: A precursor of endometrial serous adenocarcinoma characterized by the replacement of the normal endometrial cells by malignant glandular cells that resemble the malignant cells of invasive serous adenocarcinoma. The endometrial neoplastic process is non-invasive. It may coexist with invasive endometrial adenocarcinoma or can be associated with metastases outside the uterus, in the absence of invasive endometrial carcinoma.


name: Recurrent Endocervical Adenocarcinoma, Usual-Type

description: The reemergence of endocervical adenocarcinoma, usual-type after a period of remission.


Non-Neoplastic Cardiovascular Disorder

description: A non-neoplastic disorder that affects the heart and/or vessels.  Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema.


Endometrial Dedifferentiated Carcinoma

description: A carcinoma that arises from the endometrium and is characterized by the presence of an undifferentiated carcinomatous component and a second component of either FIGO grade 1 or 2 endometrioid carcinoma.


Stage IA2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 3 mm and not more than 5 mm in depth. (FIGO 2009)


Sickle Cell-SS Disease

description: A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.


Refractory Cervical Carcinoma

description: Cervical carcinoma that is resistant to treatment.


name: Human Papillomavirus-Related Cervical Carcinoma

description: A carcinoma that arises from the cervix and is caused by human papillomavirus infection.


name: Endometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with poorly differentiated carcinoma cells.


name: Stage IIIB Cervical Cancer AJCC v6 and v7

description: Stage IIIB includes: (T3b, Any N, M0); (T1-3, N1, M0).  T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Disorder of soft tissue

description: A non-neoplastic or neoplastic disorder that affects the soft tissue.


name: Female Non-Neoplastic Reproductive System Disorder

description: A non-neoplastic disorder that affects the female reproductive system. Representative examples include endometriosis, pelvic inflammatory disease, and endometritis.


name: Non-Neoplastic Connective and Soft Tissue Disorder

description: A non-neoplastic disorder that affects the connective and soft tissue.


Neoplasm by Morphology

description: A classification system grouping neoplasms according to their cellular characteristics.


Cervical Cancer by FIGO Stage 2018

description: A term that refers to the staging of cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging, 2018.


Repeat Expansion Disease

description: A class of genetic diseases that occur when microsatellite repeats expand beyond a threshold length.


Verumontanum Mucosal Gland Hyperplasia

description: A benign microacinar proliferation occurring exclusively in the verumontanum and adjacent posterior urethra where the ejaculatory ducts and utricle empty into the urethra. Crystalloids and intraluminal mucin are usually absent, but; intraluminal corpora amylacea are often present. The lining epithelium typically consists of bland cuboidal to columnar luminal cells with underlying basal cells.


Unresectable Endometrial Carcinoma

description: Endometrial carcinoma that is not amenable to surgical resection.


Neoplasm by Special Category

description: A neoplasm defined by its unique characteristic as they apply to clinical presentation and course, morphologic patterns, frequency, and/or age distribution.


Stage IB Cervical Cancer AJCC v9

description: Stage IB includes: T1b, N0, M0. T1b: Tumor with measured deepest invasion more than 5 mm (greater than FIGO stage IA); lesion limited to the cervix uteri with size measured by maximum tumor diameter. Note: The involvement of vascular/lymphatic spaces should not change the staging. The lateral extent of the lesion is no longer considered. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Stage IVB Cervical Cancer AJCC v6 and v7

description: Stage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)


name: Metastatic Carcinoma to the Uterine Cervix

description: A carcinoma that has spread to the cervix from another anatomic site.


name: Low Grade Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth.


Stage IIIA Cervical Cancer FIGO 2018

description: Cervical carcinoma that involves the lower third of the vagina, with no extension to the pelvic wall. (FIGO 2018)


Non-Neoplastic Musculoskeletal Disorder

description: A non-neoplastic disorder that affects muscles and bones.


Adenocarcinoma endometrial metastatic

description: An adenocarcinoma which originated in the endometrium and has spread to another anatomic site.


description: An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage.


name: FIGO Grade 1 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains equal to or less than 5% non-squamous solid areas.


Stage IB3 Cervical Cancer FIGO 2018

description: Invasive cervical carcinoma equal or more than 4 cm in greatest dimension. (FIGO 2018)


Stage IA Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring equal or less than 5 mm in depth and equal or less than 7 mm in width. (FIGO 2009)


AIDS-Related Cervical Carcinoma

description: A carcinoma that arises from the cervix in a patient with acquired immunodeficiency syndrome.


name: Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

description: A neoplasm of hematopoietic and lymphoid cell origin that affects the skin.


name: Cervix Intraepithelial Neoplasia Grade 3 AJCC v7

description: Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: Locally Advanced Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Schizophrenia and other psychotic disorders

description: A category of psychiatric disorders characterized by the presence of psychotic symptoms such as delusions or hallucinations or negative symptoms such as affective flattening.


Abnormal Finding

description: A decision that an observation or result is outside the parameters considered normal.


name: Recurrent Low Grade Endometrial Endometrioid Adenocarcinoma

description: The reemergence of endometrial low-grade endometrioid adenocarcinoma after a period of remission.


Stage IIIC1 Cervical Cancer FIGO 2018

description: Cervical carcinoma with pelvic lymph node metastasis only. (FIGO 2018)


Stage IVA Cervical Cancer AJCC v9

description: Stage IVA includes: T4, Any N, M0. T4: Tumor has involved (biopsy-proven) the mucosa of the bladder or rectum, or has spread to adjacent organs. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Recurrent Endometrial Transitional Cell Carcinoma

description: The reemergence of endometrial transitional cell carcinoma after a period of remission.


name: Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

description: A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of a component with undifferentiated malignant cells.


Stage IB2 Cervical Cancer

description: Stage IB2 includes: T1b2, N0, M0.  T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Pancreatobiliary Carcinoma

description: A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater.


Refractory Endometrial Carcinoma

description: Endometrial carcinoma that is resistant to treatment


Disorder by Site

description: A term that refers to the classification of a disorder according to the anatomic site that is involved in the pathologic process.


Stage III Cervical Cancer AJCC v9

description: Stage III includes: T3, N0, M0. T3: Tumor extending to pelvic sidewall and/or involving the lower third of vagina, and/or causing hydronephrosis or nonfunctioning kidney. The pelvic sidewall is defined as the muscle, fascia, neurovascular structures, and skeletal portions of the bony pelvis. Cases with no cancer-free space between the tumor and pelvic wall by rectal examination are FIGO III. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Stage I Cervical Cancer FIGO 2018

description: The carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded). (FIGO 2018)


Deformity

description: An anatomic abnormality that is either present at birth or appears later in life.


name: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 5% or less solid non-glandular, non-squamous growth.


Clinical Test Result

description: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition.


Stage IVB Cervical Cancer AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.)


Stage IIA1 Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement, less than 4 cm in greatest dimension. (FIGO 2018)


Genitourinary System Carcinoma

description: A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma.


Stage I Cervical Cancer AJCC v6 and v7

description: Stage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread.  T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Cervical Cancer by AJCC v9 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 9th edition. This staging system applies to carcinomas and carcinosarcomas. It does not apply to sarcomas, lymphomas, and melanomas. Sarcomas are staged according to the corpus uteri classification for sarcomas. Lymphomas are staged according to Hodgkin and non-Hodgkin lymphoma classification. Melanomas are not staged. (from AJCC 9th Ed.)


Stage IIA1 Cervical Cancer AJCC v8

description: Stage IIA1 includes: T2a1, Any N, M0. T2a1: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. Clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


name: Non-Neoplastic Hematologic and Lymphocytic Disorder

description: A non-neoplastic disorder that arises from hematopoietic and lymphoid cells. It is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm.


name: Recurrent Platinum-Sensitive Endometrial Carcinoma

description: The reemergence of platinum-sensitive endometrial carcinoma after a period of remission.


Stage IVB Cervical Cancer FIGO 2018

description: The cervical carcinoma has spread to distant organs. (FIGO 2018)


name: Cervical Papillary Squamous Cell Carcinoma

description: A human papillomavirus-related cervical squamous cell carcinoma characterized by the presence of papillary structures covered with epithelial cells which show features of cervical intraepithelial neoplasia. The malignant cellular component below the papillary structures is a squamous cell carcinoma.


Refractory Cervical Adenocarcinoma

description: Cervical adenocarcinoma that is resistant to treatment.


Salt-Wasting 21-Hydroxylase Deficiency

description: A classic form of congenital adrenal hyperplasia characterized by complete absence of 21-hydroxylase activity resulting in deficiency of glucocorticoids and mineralocorticoids accompanied by androgen excess causing virilization in female infants. Mineralocorticoid deficiency results in renal salt-wasting, and if untreated, hyponatremia, hyperkalemia, and shock.


Adenocarcinoma endometrial recurrent

description: The reemergence of endometrioid adenocarcinoma after a period of remission.


name: Recurrent Endometrial Serous Adenocarcinoma

description: The reemergence of endometrial serous adenocarcinoma after a period of remission.


Stage IVB Cervical Cancer FIGO 2009

description: Cervical carcinoma involving distal organs outside the pelvis. (FIGO 2009)


Stage IV Cervical Cancer FIGO 2018

description: The cervical carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. (A bullous edema, as such, does not permit a case to be allotted to Stage IV). (FIGO 2018)


Early Stage Endometrial Carcinoma

description: A stage term referring to endometrial carcinoma that is confined to the uterus.


Seropositive rheumatoid arthritis

description: Rheumatoid arthritis in which a patient's serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease.


Type II Endometrial Adenocarcinoma

description: A classification of primary endometrial adenocarcinomas that refers to clear cell adenocarcinoma, serous adenocarcinoma, and serous endometrial intraepithelial carcinoma.


Finding

description: Clinical, laboratory or molecular evidence, or absence of evidence of disease.


Stage IIA1 Cervical Cancer FIGO 2009

description: Cervical carcinoma limited to the upper two-thirds of the vagina and is equal or less than 4 cm in diameter. (FIGO 2009)


Non-Neoplastic Muscle Disorder

description: A non-neoplastic disorder that affects the smooth, skeletal, or cardiac muscles.


Stage IIA Cervical Cancer FIGO 2018

description: Cervical carcinoma limited to the upper two-thirds of the vagina without parametrial involvement. (FIGO 2018)


Stage IB1 Cervical Cancer AJCC v8

description: Stage IB1 includes: T1b1, Any N, M0. T1b1: Tumor with clinically visible lesion 4.0 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Cervical Cancer AJCC v8

description: Stage IIA includes: T2a, Any N, M0. T2a: Cervical carcinoma invading beyond the uterus but not to the pelvic wall or to lower third of vagina without parametrial invasion. M0: No distant metastasis. (AJCC 8th Ed.)


name: Refractory Endometrial Mixed Cell Adenocarcinoma

description: Endometrial mixed cell adenocarcinoma that is resistant to treatment.


Locally Recurrent Endometrial Carcinoma

description: The reemergence of endometrial carcinoma after a period of remission, at or adjacent to the site of the original tumor.


name: Cervical Squamous Cell Carcinoma, Not Otherwise Specified

description: Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available.


Stage IIIA Cervical Cancer AJCC v8

description: Stage IIIA includes: T3a, Any N, M0. T3a: Tumor involving the lower third of vagina but not extending to pelvic wall. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IB2 Cervical Cancer FIGO 2009

description: Cervical carcinoma measuring more than 5 mm in depth and more than 4 cm in maximum diameter. (FIGO 2009)


Cervical Cancer by AJCC v6 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 6th edition.


Non-Neoplastic Hepatobiliary Disorder

description: A non-neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples include hepatitis, cirrhosis, cholangitis, and cholecystitis.


Stage IVA Cervical Cancer FIGO 2009

description: Cervical carcinoma with rectal or bladder involvement. (FIGO 2009)


Laboratory Test Result

description: The outcome of a laboratory test.


Residual schizophrenia

description: A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs).


name: FIGO Grade 3 Endometrial Mucinous Adenocarcinoma

description: A primary mucinous adenocarcinoma of the endometrium that contains more than 50% non-squamous solid areas.


Unresectable Cervical Carcinoma

description: Cervical carcinoma that is not amenable to surgical resection.


thiosulfate

An ester of thiosulfuric acid.


organic thiosulfate

The organic ester of thiosulfuric acid.


A trans-1,2-dihydronaphthalene-1,2-diol with a (1R,2R)-configuration.


The (1S,2S)-isomer of trans-1,2-dihydronaphthalene-1,2-diol.


METHAMPHETAMINE HYDROCHLORIDE

A hydrochloride having methamphetamine as the base component.


zuranolone

A 3-hydroxy steroid that is 5beta-19-norpregnane substituted by hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20 and 21, respectively. It is a positive allosteric modulator of GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults.


A 3beta-sterol that consists of 24-methylcholest-6-en-3beta-ol with a peroxy group between positions 5 and 8 and a methylene group between positions 22 and 23. An antineoplastic agent isolated from  Sinularia sp.


A hydrobromide salt prepared from N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.


A D-proline derivative that is D-proline monohydroxylated at position 3 (the cis-3-hydroxy-diastereomer).


hydroxyproline

A proline derivative that is proline substituted by at least one hydroxy group.


The (3R)-trans--diastereomer of 3-hydroxy-D-proline.


The D-stereoisomer of 4-hydroxyproline.


The L-stereoisomer of 3-hydroxyproline.


monohydroxyproline

A hydroxy-amino acid in which the amino acid specified is proline. A "closed" class.


pyroglutamic acid

An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.


oxoproline

A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent.


The (3R)-cis-diastereomer of 3-hydroxy-L-proline.


The L-stereoisomer of 4-hydroxyproline.


L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).


(R)-clenbuterol hydrochloride

The monohydrochoride salt of (R)-clenbuterol.


(+)-dihydroisorhamnetin

A dihydroisorhamnetin that has 2R,3R-configuration.


The (25R)-diastereomer of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al.


colchicine

A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.


(R)-colchicine

A colchicine that has (R)-configuration.


haloindole

A compound based on an indole skeleton, containing one or more halogen atoms


spongotine A

A member of the class of imidazolines that is 4,5-dihydro-1H-imidazole which is substituted by a 1H-indole-3-carbonyl group at position 2 and a 6-bromo-1H-indol-3-yl group at position 4S. It is a bisindole alkaloid isolated from the marine sponge, Spongosorites sp.


dichlorochromopyrrolic acid

A pyrrole-2,5-dicarboxylic acid having 7-chloroindol-3-yl groups at the 3- and 4-positions.


chloroindole

A compound based on an indole skeleton, containing one or more chlorine atoms


ISOXAZOLE

A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of  isoxazoles.


lotilaner

A member of the class of isoxazoles that is 4,5-dihydro-1,2-oxazole substituted by 4-methyl-5-({2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}carbamoyl)thiophen-2-yl, trifluoromethyl, and 3,4,5-trichlorophenyl groups at positions 3, 5 and 5, respectively (the 5S-stereoisomer). It is a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor selective for mites, approved for the treatment of Demodex blepharitis.


methyl propenyl ketone

An enone that is pent-2-ene in which the two methylene hydrogens have been replaced by an oxo group.


magnesium dichloride monohydrate

A hydrate that is the monohydrate form of magnesium dichloride.


magnesium chloride

A magnesium salt comprising of two chlorine atoms bound to a magnesium atom.


magnesium dichloride dihydrate

A hydrate that is the dihydrate form of magnesium dichloride.


UDP-rhamnose

A UDP-sugar in which the sugar component is rhamnose.


UDP-L-rhamnose

A UDP-rhamnose in which the rhamnose component has L-configuration.


amorolfine hydrochloride

A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used for the topical treatment of fungal nail and skin infections.


nutrient

A nutrient is a food component that an organism uses to survive and grow.


D-glyceraldehyde

The D-enantiomer of glyceraldehyde.


The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.


The dihydrate of a tris(1,10-phenanthroline)ruthenium(2+) dichloride salt.


(24S)-24-hydroxycholesterol 3-hexanoate

A sterol ester that is the 3-hexanoyl derivative of (24S)-24-hydroxycholesterol.


hexanoate ester

Any fatty acid ester where the carboxylic acid component is hexanoic (also known as caproic) acid.


hydrocortisone caproate

The 21-O-hexanoyl derivative of hydrocortisone.


3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al with S-configuration at C-24.


OXAZOLE

A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.


A methyl-branched fatty acyl-CoA in which the unspecified acyl group carries a methyl substituent at position 2.


dihydroconiferyl alcohol

A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.


A hydrochloride salt resulting from the reaction of (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane with 2 mol eq. of hydrogen chloride. An ATP-competitive inhibitor of Rho kinase (ROCK).


indole

Either of two isomeric forms comprising a benzene ring fused to a pyrrole ring.


BENZO[D]OXAZOLE

A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.


long-chain primary fatty alcohol

A long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.


An  oxysterol that is cholesterol substituted  by hydroxy groups at positions 20 and 22 (the 20R,22R-stereoisomer).


(R)-cyclopentolate

The (R)-enantiomer of cyclopentolate.


(S)-cyclopentolate

The (S)-enantiomer of cyclopentolate.


deoxyviolacein

A member of the class of oxindoles resulting from formal oxidative coupling between the 3-position of 1,3-dihydro-2H-indol-2-one and the 3-position of 1,3-dihydro-2H-pyrrol-2-one, which is substituted at the 5 position by a 1H-indol-3-yl group, where the newly-formed double bond has E configuration.


fatty acid 16:2

Any polyunsaturated fatty acid containing 16 carbons and 2 double bonds.


tetramine

Any polyamine that contains four amino groups.


acrovestone

A polyphenol that is isolated from Acronychia pedunculata and exhibits moderate antioxidant and antityrosinase activities.


nucleobase analogue

A molecule that can substitute for a normal nucleobase in nucleic acids.


methylthymine

A pyrimidone that is thymine bearing a single methyl substituent.


A member of the class of pyrrolecarboxamides that is 1H-pyrrole substituted by [1-(3a,7a-dihydro-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl, (4-methylpiperazin-1-yl)carbonyl, and naphthalen-1-yl groups at positions 1, 3 and 4, respectively. It is a potent inhibitor of Ras farnesyltransferase (IC50= 0.9nM against H-Ras and 2.4nM against K-Ras) with potential anticancer activity.


(S)-bambuterol hydrochloride

The hydrochloride salt of (S)-bambuterol.


L-cysteine thioether

Any L-cysteine derivative obtained by conversion of the thiol group into a sulfide.


oxoicosatetraenoic acid

Any C20 polyunsaturated fatty acid having four double bonds and at least one oxo group.


cinnamic acid

A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.


A member of the class of  pyrroles that is 2,3-dihydro-1H-pyrrole substituted by a 9-methyl-8,10-dioxodec-2-en-10-yl group at the nitrogen atom. Isolated from Penicillium citrinum and Penicillium brevicompactum, it exhibits antifungal activity.


zinc cation

Any zinc ion that is positively charged.


thiencarbazone-methyl

An N-sulfonylurea in which the sulfur atom is attached to a 4-(methoxycarbonyl)-2-methylthiophen-3-yl group and in which the non-sulfonated nitrogen is substituted by a 3-methoxy-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl group. It is a herbicide used for the selective control of grasses and broadleaf weeds primarily in corn.


cellobiose

A glycosylglucose consisting of two glucose units linked via a beta(1->4) bond.


lactose

A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.


D-glucose

A glucopyranose having D-configuration.


A glucose with D-configuration.


2,3-saturated fatty aldehyde

Any fatty aldehyde that is saturated at positions 2 and 3.


mefloquine

A racemate composed of (+)-(11R,2'S)- and (-)-(11S,2'R)-enantiomers of mefloquine. An antimalarial agent which acts as a blood schizonticide; its mechanism of action is unknown.


decarboxytiaprofenic acid

A thiophene substituted at C-2 by benzoyl and at C-4 by an ethyl group.


D-mannose

D-Mannose in its six-membered ring form.


A 3beta-sterol that is 5alpha-ergosta-7,24(28)-diene which is substituted at the  3beta and 4alpha positions by hydroxy and formyl groups, respectively.


A 3-hydroxy steroid that is 24-methylene-19-norcholesta-1,3,5(10)-triene substituted by a hydroxy group at position 3. It is isolated from Hainan soft coral Dendronephthya studeri.


An androstanoid that is androstane substituted by oxo groups at positions 3 and 17.


cadaverine dihydrochloride

A hydrochloride resulting from the reaction of cadaverine with 2 mol eq. of hydrogen chloride.


phosphorus-33 atom

The radioactive isotope of phosphorus with relative atomic mass 32.971725, half-life of 25.34 days and nuclear spin (1)/2.


A steroid glucosiduronic acid that is 4-hydroxyestrone having a single beta-D-glucuronic acid residue attached at position 3.


saturated fatty aldehyde

A fatty aldehyde in which there is no carbon-carbon unsaturation.


MIANSERIN HYDROCHLORIDE

The hydrochloride salt of mianserin, a tetracyclic compound with antidepressant effects.


quinone

Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).


menaquinone

Any member of the class of menaquinones that is 2-methyl-1,4-naphthoquinone with an unsaturated isoprenoid chain at the 3-position.


vitamin K

Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.


polyprenylbenzoquinone

Any member of the class of 1,4-benzoquinones substituted by a polyprenyl-derived side-chain.


Any 1,4-benzoquinone carrying a single hydroxy substituent.


A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.


hydroxyanthraquinones

An anthraquinone substituted with one or more hydroxy groups.


prenylquinone

A quinone substituted by a polyprenyl-derived side-chain. Prenylquinones occur in all living cells. Due to their amphiphilic character, they are mainly located in biological membranes where they function as electron and proton carriers in the photosynthetic and respiratory electron transport chains. Some prenylquinones also perform more specialised roles sucy as antioxidants and enzyme cofactors. Prenylquinones are classified according to ring structure: the main classes are menaquinones, phylloquinones, ubiquinones and plastoquinones.


Any member of the class of benzoquinones that is 1,4-benzoquinone or its C-substituted derivatives.


hydroxybenzoquinone

Benzoquinones with at least one hydroxy substituent.


acenoquinone

Quinones containing an acene fused ring system.


orthoquinones

Any quinone in which the carbons of the two carbonyl groups in the quinone system are joined to each other by a single bond.


Coenzyme Q6

A ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2.


menaquinones

Any prenylnaphthoquinone having a prenyl or polyprenyl group at position 3 and a methyl group at position 2 on the naphthoquinone ring.


prenylnaphthoquinone

Any napthoquinone that is substituted at position 2 by a prenyl or polyprenyl group. The term also includes compounds that are functionalised on the prenyl or polyprenyl chain (e.g. by a hydroxy group).


Any napthoquinone in which the oxo groups of the quinone moiety are at the 1 and 2 positions of the naphthalene ring.


p-quinones

A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring.


A compound whose structure comprises a 2,3-dimethoxy-5-methylbenzoquinone nucleus, common to ubiquinones; and a side chain of seven isoprenoid units.


A geometric isomer of ubiquinone-10 in which the double bonds at positions 2, 10 and 26 are in the Z conformation.


naphthoquinone

A polycyclic aromatic ketone metabolite of naphthalene.


A ubiquinone whose structure comprises a 2,3-dimethoxy-5-methylbenzoquinone nucleus (common to all ubiquinones) and a side chain of eight isoprenoid units.