pseudophosphatase activity

description: Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.


name: cyclin-dependent protein kinase activating kinase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).


name: phosphatidylinositol 3-kinase activator activity

description: Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K).


peroxidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of peroxidase.


urease activator activity

description: Increases the activity of urease by promoting the incorporation of nickel into the active site.


name: phosphatidylinositol 3-kinase inhibitor activity

description: Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K).


melanin-concentrating hormone activity

description: The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.


digestive hormone activity

description: The action characteristic of a hormone that takes part in the digestion process.


name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


adenylate cyclase regulator activity

description: Binds to and modulates the activity of adenylate cyclase.


description: Binds to and increases the activity of an endodeoxyribonuclease.


name: tyrosine 3-monooxygenase activator activity

description: Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase).


mating pheromone activity

description: The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.


name: tryptophan hydroxylase activator activity

description: Increases the activity of the enzyme tryptophase hydroxylase.


name: glutamate-cysteine ligase regulator activity

description: Binds to and modulates the activity of glutamate-cysteine ligase.


ligase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a ligase.


melanocyte-stimulating hormone activity

description: The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates.


name: aldehyde dehydrogenase (NAD+) inhibitor activity

description: Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+).


name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity

description: Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase.


transporter inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of a transporter.


myoinhibitory hormone activity

description: The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction.


phospholipase D activator activity

description: Binds to and increases the activity of the enzyme phospholipase D.


name: polynucleotide adenylyltransferase activator activity

description: Increases the activity of the enzyme polynucleotide adenylyltransferase.


name: acetylcholine receptor inhibitor activity

description: Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.


phospholipase D inhibitor activity

description: Binds to and stops, prevents or reduces the activity of phospholipase D.


name: receptor signaling protein tyrosine kinase inhibitor activity

description: Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.


prothoracicotrophic hormone activity

description: The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects.


follicle-stimulating hormone activity

description: The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.


name: methionine adenosyltransferase regulator activity

description: Binds to and modulates the activity of methionine adenosyltransferase.


name: cyclin-dependent protein kinase activating kinase regulator activity

description: Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase.


deubiquitinase activator activity

description: Binds to and increases the activity of a deubiquitinase.


phospholipase C activator activity

description: Binds to and increases the activity of the enzyme phospholipase C.


name: pituitary adenylate cyclase activating polypeptide activity

description: The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.


adenylate cyclase inhibitor activity

description: Binds to and decreases the activity of adenylate cyclase.


name: cysteine-type endopeptidase activator activity

description: Binds to and increases the activity of a cysteine-type endopeptidase.


ubiquitin ligase activator activity

description: Binds to and increases the activity of a ubiquitin ligase.


name: guanyl nucleotide exchange factor inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.


competence pheromone activity

description: A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence.


phospholipase C inhibitor activity

description: Binds to and stops, prevents or reduces the activity of the enzyme phospholipase C.


death receptor agonist activity

description: Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.


DNA strand exchange activator activity

description: Binds to and increases a DNA strand exchange activity.


name: miRNA inhibitor activity via base-pairing

description: Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs).


L-dopa decarboxylase activator activity

description: Interacts with and increases L-dopa decarboxylase activity.


description: Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity.


growth hormone activity

description: The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth.


name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity

description: Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.


name: UTP:glucose-1-phosphate uridylyltransferase regulator activity

description: Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase.


molecular function activator activity

description: A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


name: receptor signaling protein tyrosine kinase activator activity

description: Binds to and increases the activity of a receptor signaling protein tyrosine kinase.


name: pathogen-derived receptor ligand activity

description: The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity.


name: cyclic nucleotide phosphodiesterase activator activity

description: Binds to and increases the activity of cyclic nucleotide phosphodiesterase.


name: cyclin-dependent protein serine/threonine kinase activator activity

description: Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.


name: acetylcholine receptor activator activity

description: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.


endoribonuclease inhibitor activity

description: Binds to and stops, prevents or reduces the activity of endoribonuclease.


RNA helicase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of an RNA helicase.


name: potassium channel activator activity involved in G protein-coupled receptor signaling pathway

description: Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.


name: ornithine carbamoyltransferase inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase.


pectinesterase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of pectinesterase.


name: eukaryotic elongation factor-2 kinase regulator activity

description: Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase.


ion channel regulator activity

description: Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


myosin phosphatase regulator activity

description: Binds to and modulates of the activity of myosin phosphatase.


exoribonuclease activator activity

description: Binds to and increases the activity of an exoribonuclease.


ecdysis-triggering hormone activity

description: The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.


GTP cyclohydrolase I regulator activity

description: Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.


methyltransferase regulator activity

description: Binds to and modulates the activity of a methyltransferase.


name: tRNA methyltransferase activator activity

description: Binds to and increases the activity of a methyltransferase.


mRNA phosphatase activator activity

description: Binds to and increases the activity of mRNA phosphatase.


name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity

description: Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


name: xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity

description: Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase.


name: interleukin-1 type II receptor antagonist activity

description: Blocks the binding of interleukin-1 to interleukin-1 type II receptors.


peptidyl-dipeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain.


name: nitric-oxide synthase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of nitric oxide synthase.


name: interleukin-1 type I receptor antagonist activity

description: Blocks the binding of interleukin-1 to interleukin-1 type I receptors.


name: small conductance calcium-activated potassium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel.


name: RNA lariat debranching enzyme activator activity

description: Binds to and increases the activity of an RNA lariat debranching enzyme.


name: 1-phosphatidylinositol 4-kinase activator activity

description: Binds to and increases the activity of 1-phosphatidylinositol 4-kinase.


tRNA ligase activator activity

description: Binds to and increases the activity of a tRNA ligase.


name: acetolactate synthase regulator activity

description: Binds to and modulates the activity of acetolactate synthase.


name: calcium-dependent cysteine-type endopeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner.


name: eukaryotic elongation factor-2 kinase activator activity

description: Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase.


activin receptor antagonist activity

description: Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.


sphingolipid activator protein activity

description: Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.


transporter regulator activity

description: Binds to and modulates the activity of a transporter.


name: outward rectifier potassium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.


name: dolichol-phosphate-mannose synthase regulator activity

description: Binds to and modulates the activity of dolichol-phosphate-mannose synthase.


name: ion channel regulator activity involved in G protein-coupled receptor signaling pathway

description: Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling.


nuclease inhibitor activity

description: Binds to and modulates the activity of a nuclease.


polygalacturonase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of polygalacturonase.


pheromone activity

description: The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant.


nuclease activator activity

description: Binds to and increases the activity of a nuclease.


name: ribonucleoside-diphosphate reductase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase.


recombinase activator activity

description: Binds to and increases the activity of a recombinase.


name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity

description: Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


name: inward rectifier potassium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.


name: guanyl nucleotide exchange factor activator activity

description: Binds to and increases the activity of a guanyl nucleotide exchange factor.


chemokine receptor antagonist activity

description: Interacts with chemokine receptors to reduce the action of a chemokine.


thyrotropin-releasing hormone activity

description: The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.


SUMO ligase regulator activity

description: Binds to and modulates the activity of a SUMO ligase.


name: fibroblast growth factor receptor antagonist activity

description: Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.


description: The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.


name: guiding stereospecific synthesis activity

description: The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis.


DNA strand exchange inhibitor activity

description: Binds to and stops, prevents or reduces a DNA strand exchange activity.


alpha-amylase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of alpha-amylase.


myostimulatory hormone activity

description: The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction.


cyclase inhibitor activity

description: Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction.


G protein activity

description: A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).


ubiquitin ligase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.


ecdysiostatic hormone activity

description: The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion.


adenylate cyclase activator activity

description: Binds to and increases the activity of adenylate cyclase.


ribonuclease activator activity

description: Binds to and increases the activity of a ribonuclease.


molecular function inhibitor activity

description: A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.


diuretic hormone activity

description: The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.


neuropeptide activity

description: The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron.


lysozyme inhibitor activity

description: Binds to and stops, prevents or reduces the activity of lysozyme.


deoxyribonuclease inhibitor activity

description: Binds to and stops, prevents or reduces the activity of deoxyribonuclease.


name: guanyl-nucleotide exchange factor adaptor activity

description: The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.


dUTP pyrophosphatase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase.


potassium channel activator activity

description: Binds to and increases the activity of a potassium channel, resulting in its opening.


name: Penile squamous cell carcinoma metastatic

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Squamous cell carcinoma of the penis that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Penile Squamous Cell Carcinoma

description: Penile squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Nuclear Expression of STAT6 Protein

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A finding indicating the presence of STAT6 nuclear signal in tumor cells by immunohistochemistry. It results from the fusion of the NAB2 and STAT6 genes.


2-butanone oxidase activity

description: Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate.


name: negative regulation of photomorphogenesis

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that stops, reduces or prevents photomorphogenesis.


Childhood Protoplasmic Astrocytoma

description: A protoplasmic astrocytoma that occurs during childhood.


name: Recurrent Childhood Protoplasmic Astrocytoma

description: The reemergence of protoplasmic astrocytoma in childhood after a period of remission.


name: Malignant fibrous histiocytoma recurrent

description: Reemergence of undifferentiated pleomorphic sarcoma after a period of remission.


Elevated HMGA2

description: A finding indicating elevated concentrations of HMGA2 in a sample.


name: positive regulation of brain-derived neurotrophic factor-activated receptor activity

description: Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


name: positive regulation of protein-pyridoxal-5-phosphate linkage

description: Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


positive regulation of kinin cascade

description: Any process that activates or increases the frequency, rate, or extent of the kinin cascade.


name: positive regulation of cap-dependent translational initiation

description: Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation.


name: regulation of hepatocyte growth factor production

description: Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production.


positive regulation of CD86 production

description: Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process.


regulation of translation at synapse

description: Any process that regulates translation occurring at the synapse.


regulation of protein phosphorylation

description: Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.


name: regulation of glucosylceramide catabolic process

description: Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process.


name: positive regulation of proteolysis associated with antigen processing and presentation

description: Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of CD24 production

description: Any process that modulates the frequency, rate or extent of CD24 biosynthetic process.


name: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division

description: Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division.


name: negative regulation of hepatocyte growth factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production.


name: regulation of gliotoxin biosynthetic process

description: Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process.


name: positive regulation of aspartic-type peptidase activity

description: Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity.


name: positive regulation of myosin light chain kinase activity

description: Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.


name: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity

description: Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate.


name: positive regulation of tubulin deacetylation

description: Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


name: positive regulation of protein histidine kinase activity

description: Any process that increases the frequency, rate or extent of protein histidine kinase activity.


name: regulation of lysosomal protein catabolic process

description: Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.


name: negative regulation of formation of translation initiation ternary complex

description: Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.


name: positive regulation of translation in response to oxidative stress

description: Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


name: regulation of glucosylceramide biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


name: regulation of protein histidine kinase activity

description: Any process that modulates the frequency, rate or extent of protein histidine kinase activity.


name: negative regulation of inhibitory G protein-coupled receptor phosphorylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


regulation of amyloid fibril formation

description: Any process that modulates the frequency, rate or extent of amyloid fibril formation.


name: negative regulation of ferricrocin biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process.


name: regulation of protein modification process

description: Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


name: regulation of sphingomyelin catabolic process

description: Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process.


name: positive regulation of translational frameshifting

description: Any process that activates or increases the frequency, rate or extent of translational frameshifting.


name: negative regulation of proteolysis associated with antigen processing and presentation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


name: regulation of PSII associated light-harvesting complex II catabolic process

description: Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II.


name: negative regulation of protein processing in phagocytic vesicle

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle.


name: positive regulation of tissue kallikrein-kinin cascade

description: Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


name: positive regulation of protein K63-linked deubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination.


name: regulation of elastin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


name: positive regulation of selenocysteine incorporation

description: Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation.


name: regulation of N-terminal peptidyl-lysine acetylation

description: Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


name: regulation of translational initiation in response to osmotic stress

description: Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: negative regulation of protein K48-linked ubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


name: positive regulation of protein modification process

description: Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


name: positive regulation of protein O-linked glycosylation

description: Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.


name: positive regulation of ubiquitin-specific protease activity

description: Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.


name: siRNA-mediated gene silencing by inhibition of translation

description: An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs.


name: positive regulation of peptidyl-L-cysteine S-palmitoylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


name: regulation of translation involved in cellular response to UV

description: Any regulation of translation that is involved in cellular response to UV.


name: negative regulation of gliotoxin biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process.


name: regulation of mitochondrial translational initiation

description: Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


name: regulation of Rho-dependent protein serine/threonine kinase activity

description: Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity.


name: negative regulation of blood coagulation, common pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway.


regulation of CD80 production

description: Any process that modulates the frequency, rate or extent of CD80 biosynthetic process.


name: regulation of blood coagulation, intrinsic pathway

description: Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway.


name: negative regulation of mitochondrial translation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


name: positive regulation of amide catabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


name: negative regulation of translation initiation in response to endoplasmic reticulum stress

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


regulation of urea catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea.


name: regulation of ferricrocin biosynthetic process

description: Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process.


name: negative regulation of protein neddylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation.


name: negative regulation of peptidyl-L-cysteine S-palmitoylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


name: negative regulation of peptidyl-serine phosphorylation of STAT protein

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


name: negative regulation of protein glutathionylation

description: Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


name: positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

description: Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


name: sucrose induced translational repression

description: Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level.


name: negative regulation of protein desumoylation

description: Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


name: negative regulation of I-kappaB phosphorylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation.


regulation of protein adenylylation

description: Any process that modulates the frequency, rate or extent of protein adenylylation.


name: negative regulation of protein lipidation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation.


regulation of protein desumoylation

description: Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


name: positive regulation of amyloid fibril formation

description: Any process that activates or increases the frequency, rate or extent of amyloid fibril formation.


name: positive regulation of translational fidelity

description: Any process that increases the ability of the translational apparatus to interpret the genetic code.


name: regulation of translational initiation by tRNA modification

description: A process in which translation initiation is regulated by post-translation modifications of a tRNA molecule.


name: positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

description: Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation.


name: negative regulation of non-membrane spanning protein tyrosine kinase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


name: negative regulation of brain-derived neurotrophic factor-activated receptor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


name: negative regulation of protein autoubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.


negative regulation of CD80 production

description: Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process.


name: positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process.


name: positive regulation of Toll receptor ligand protein activation cascade

description: Any process that activates or increases the frequency, rate or extent of Toll receptor ligand protein activation cascade.


name: regulation of cytoplasmic translational fidelity

description: Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.


name: negative regulation of protein tyrosine phosphatase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity.


name: negative regulation of emericellamide biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process.


name: negative regulation of translational frameshifting

description: Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting.


name: regulation of emericellamide A biosynthetic process

description: Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process.


name: positive regulation of peptide hormone processing

description: Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


name: regulation of N-terminal peptidyl-methionine acetylation

description: Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


negative regulation of kinin cascade

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.


name: negative regulation of plasma kallikrein-kinin cascade

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


positive regulation of CD24 production

description: Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process.


regulation of lymphotoxin A production

description: Any process that modulates the frequency, rate, or extent of lymphotoxin A production.


name: positive regulation of elastin biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


name: negative regulation of amyloid fibril formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.


name: negative regulation of glucosylceramide biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


name: positive regulation of protein metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.


name: regulation of peptidyl-L-cysteine S-palmitoylation

description: Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation.


name: negative regulation of protein geranylgeranylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation.


name: positive regulation of blood coagulation, intrinsic pathway

description: Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway.


name: positive regulation of protein polyglycylation

description: Any process that activates or increases the frequency, rate or extent of protein polyglycylation.


name: positive regulation of mitochondrial translation in response to stress

description: Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress.


name: positive regulation of translation, ncRNA-mediated

description: Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein.


regulation of SUMO transferase activity

description: Any process that modulates the frequency, rate or extent of SUMO ligase activity.


name: positive regulation of protein geranylgeranylation

description: Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation.


name: regulation of N-terminal protein palmitoylation

description: Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein.


name: regulation of proteolysis associated with antigen processing and presentation

description: Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.


regulation of amide catabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


name: regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

description: Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation.


name: negative regulation of elastin catabolic process

description: Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


name: regulation of translation at presynapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.


name: negative regulation of emericellamide A biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process.


name: negative regulation of cap-independent translational initiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation.


name: regulation of ferrichrome biosynthetic process

description: Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process.


regulation of oskar mRNA translation

description: Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.


name: negative regulation of hemoglobin biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


name: negative regulation of translational termination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.


name: regulation of protein K63-linked deubiquitination

description: Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination.


name: regulation of pseurotin A biosynthetic process

description: Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process.


name: regulation of brain-derived neurotrophic factor-activated receptor activity

description: Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


name: regulation of eIF2 alpha phosphorylation by dsRNA

description: Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA.


name: negative regulation of lipoprotein lipid oxidation

description: Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group.


name: regulation of cap-dependent translational initiation

description: Any process that modulates the frequency, rate or extent of cap-dependent translational initiation.


name: regulation of translation at postsynapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.


name: negative regulation of pentose-phosphate shunt

description: Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt.


name: positive regulation of sphingomyelin catabolic process

description: Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process.


regulation of protein neddylation

description: Any process that modulates the frequency, rate or extent of protein neddylation.


name: regulation of protein K48-linked ubiquitination

description: Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.


regulation of elastin catabolic process

description: Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


name: regulation of formation of translation preinitiation complex

description: Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex.


name: negative regulation of metallopeptidase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity.


name: positive regulation of Lys63-specific deubiquitinase activity

description: Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity.


name: positive regulation of anaphase-promoting complex-dependent catabolic process

description: Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


name: regulation of blood coagulation, extrinsic pathway

description: Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway.


negative regulation of FasL production

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


positive regulation of CD80 production

description: Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process.


name: negative regulation of myosin light chain kinase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.


name: positive regulation of lymphotoxin A production

description: Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production.


name: positive regulation of translational initiation in response to osmotic stress

description: Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: regulation of mitochondrial translational elongation

description: Any process that modulates the frequency, rate or extent of mitochondrial translational elongation.


name: positive regulation of urea catabolic process

description: Any process that activates or increases the frequency, rate or extent of urea catabolic process.


name: negative regulation of protein linear polyubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination.


name: negative regulation of Toll receptor ligand protein activation cascade

description: Any process that stops, prevents or reduces the frequency, rate or extent of Toll receptor ligand protein activation cascade.


name: negative regulation of peptide hormone processing

description: Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


name: regulation of cytoplasmic translational initiation in response to stress

description: Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


name: positive regulation of N-terminal peptidyl-methionine acetylation

description: Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


name: regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

description: Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


name: regulation of myosin light chain kinase activity

description: Any process that modulates the frequency, rate or extent of myosin light chain kinase activity.


name: negative regulation of ceramide biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.


name: negative regulation of protein catabolic process in the vacuole

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole.


name: negative regulation of cytoplasmic translational initiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation.


name: positive regulation of formation of translation preinitiation complex

description: Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex.


name: positive regulation of N-terminal peptidyl-serine acetylation

description: Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation.


name: negative regulation of cap-dependent translational initiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation.


name: negative regulation of protein histidine kinase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity.


name: negative regulation of tubulin deacetylase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity.


name: positive regulation of SUMO transferase activity

description: Any process that activates or increases the frequency, rate or extent of SUMO transferase activity.


name: negative regulation of translational initiation in response to starvation

description: Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment.


regulation of metallopeptidase activity

description: Any process that modulates the frequency, rate or extent of metallopeptidase activity.


name: regulation of protein geranylgeranylation

description: Any process that modulates the frequency, rate or extent of protein geranylgeranylation.


viral translational readthrough

description: The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.


regulation of protein metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.


name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.


regulation of protein glutathionylation

description: Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


name: positive regulation of myosin-light-chain-phosphatase activity

description: Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.


name: negative regulation of oskar mRNA translation

description: Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein.


name: positive regulation of glucosylceramide biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide.


name: negative regulation of SUMO transferase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity.


regulation of protein deneddylation

description: Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein.


name: positive regulation of cytoplasmic translational elongation

description: Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation.


name: negative regulation of protein oxidation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation.


name: positive regulation of oskar mRNA translation

description: Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.


pyrrolysine incorporation

description: The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases.


name: positive regulation of pentose-phosphate shunt

description: Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt.


name: positive regulation of blood coagulation, extrinsic pathway

description: Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway.


regulation of actin phosphorylation

description: Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.


name: eIF2alpha dephosphorylation in response to endoplasmic reticulum stress

description: The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.


name: negative regulation of translation in response to oxidative stress

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


name: negative regulation of anaphase-promoting complex-dependent catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


name: positive regulation of protein serine/threonine phosphatase activity

description: Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity.


name: negative regulation of translational initiation by iron

description: Any process involving iron that stops, prevents or reduces the rate of translational initiation.


name: negative regulation of mitochondrial translational initiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


name: negative regulation of amide catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.


name: positive regulation of N-terminal peptidyl-lysine acetylation

description: Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


name: regulation of translation by machinery localization

description: Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.


name: positive regulation of protein tyrosine phosphatase activity

description: Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity.


name: regulation of cytoplasmic translation in response to stress

description: Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


name: regulation of aspartic-type peptidase activity

description: Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity.


name: positive regulation of lysosomal protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.


name: regulation of protein serine/threonine phosphatase activity

description: Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.


name: regulation of translation at postsynapse

description: Any process that regulates translation occurring at the postsynapse.


name: positive regulation of inhibitory G protein-coupled receptor phosphorylation

description: Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


name: regulation of translation involved in anterior/posterior axis specification

description: Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis.


name: negative regulation of elastin biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.


name: regulation of protein-pyridoxal-5-phosphate linkage

description: Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


name: positive regulation of post-translational protein modification

description: Any process that activates or increases the frequency, rate or extent of post-translational protein modification.


name: positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

description: Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation.


name: negative regulation of tubulin deacetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.


name: negative regulation of formation of translation preinitiation complex

description: Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex.


name: positive regulation of blood coagulation, common pathway

description: Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway.


name: positive regulation of pseurotin A biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process.


name: negative regulation of protein polyglycylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation.


name: regulation of non-membrane spanning protein tyrosine kinase activity

description: Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


name: positive regulation of mitochondrial translational elongation

description: Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation.


name: negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

description: Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


regulation of translation at presynapse

description: Any process that regulates translation occurring at the presynapse.


name: negative regulation of protein-pyridoxal-5-phosphate linkage

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage.


name: positive regulation of translation initiation in response to endoplasmic reticulum stress

description: Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


name: positive regulation of protein adenylylation

description: Any process that activates or increases the frequency, rate or extent of protein adenylylation.


name: positive regulation of plasma kallikrein-kinin cascade

description: Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


name: negative regulation of N-terminal peptidyl-methionine acetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation.


name: regulation of translation in response to oxidative stress

description: Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


name: negative regulation of pseurotin A biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process.


regulation of kinin cascade

description: Any process that modulates the frequency, rate, or extent of the kinin cascade.


name: positive regulation of glucosylceramide catabolic process

description: Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process.


name: negative regulation of protein adenylylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation.


name: regulation of emericellamide biosynthetic process

description: Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process.


name: negative regulation of translational initiation in response to osmotic stress

description: Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: regulation of protein tyrosine phosphatase activity

description: Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity.


name: positive regulation of hepatocyte growth factor production

description: Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production.


name: negative regulation of Rho-dependent protein serine/threonine kinase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity.


name: regulation of inhibitory G protein-coupled receptor phosphorylation

description: Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation.


name: regulation of selenocysteine incorporation

description: Any process that modulates the frequency, rate or extent of selenocysteine incorporation.


name: negative regulation of granulocyte macrophage colony-stimulating factor production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


name: positive regulation of elastin catabolic process

description: Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.


name: positive regulation of non-membrane spanning protein tyrosine kinase activity

description: Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.


name: positive regulation of metallopeptidase activity

description: Any process that activates or increases the frequency, rate or extent of metallopeptidase activity.


positive regulation of FasL production

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


name: regulation of cytoplasmic translational termination

description: Any process that modulates the frequency, rate or extent of cytoplasmic translational termination.


name: negative regulation of ferrichrome biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process.


name: negative regulation of cytoplasmic translational initiation in response to stress

description: Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.


name: negative regulation of ferrichrome biosynthetic process in response to iron

description: Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus.


name: negative regulation of protein metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.


name: negative regulation of protein K63-linked deubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination.


name: regulation of peptidyl-lysine crotonylation

description: Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein.


name: regulation of tissue kallikrein-kinin cascade

description: Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


regulation of FasL production

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.


name: regulation of protein catabolic process at presynapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.


name: negative regulation of tissue kallikrein-kinin cascade

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade.


regulation of protein polyglycylation

description: Any process that modulates the frequency, rate or extent of protein polyglycylation.


name: positive regulation of tubulin deacetylase activity

description: Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity.


name: positive regulation of protein glutathionylation

description: Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.


name: positive regulation of mitochondrial translational initiation

description: Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


name: regulation of plasma kallikrein-kinin cascade

description: Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade.


name: negative regulation of blood coagulation, extrinsic pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway.


name: negative regulation of mitochondrial translational elongation

description: Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation.


name: negative regulation of translation in response to endoplasmic reticulum stress

description: Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


name: positive regulation of protein neddylation

description: Any process that activates or increases the frequency, rate or extent of protein neddylation.


name: negative regulation of lymphotoxin A production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production.


regulation of CD86 production

description: Any process that modulates the frequency, rate or extent of CD86 biosynthetic process.


name: negative regulation of selenocysteine incorporation

description: Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation.


name: negative regulation of translation in response to osmotic stress

description: Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: regulation of N-terminal peptidyl-serine acetylation

description: Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation.


name: regulation of translational frameshifting

description: Any process that modulates the frequency, rate or extent of translational frameshifting.


name: positive regulation of translation in response to osmotic stress

description: Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: regulation of Toll receptor ligand protein activation cascade

description: Any process that modulates the frequency, rate or extent of the Toll receptor ligand protein activation cascade.


ribosome hibernation

description: A cellular process that results in the silencing of ribosomes in quiescent cells. Quiescence takes place when cells encounter unfavorable conditions and cease to grow in bacteria and yeast. It also takes place in some specialized cells in higher eukaryotes, such as eggs. Ribosomes in a hibernation state are kept silent via association with proteins with inhibitory and protective functions.


name: negative regulation of protein serine/threonine phosphatase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein serine/threonine phosphatase activity.


name: regulation of blood coagulation, common pathway

description: Any process that modulates the frequency, rate or extent of blood coagulation, common pathway.


name: regulation of protein O-linked glycosylation

description: Any process that modulates the frequency, rate or extent of protein O-linked glycosylation.


name: regulation of tubulin deacetylase activity

description: Any process that modulates the frequency, rate or extent of tubulin deacetylase activity.


name: negative regulation of blood coagulation, intrinsic pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway.


name: negative regulation of peptidyl-lysine crotonylation

description: Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein.


name: positive regulation of chaperone-mediated autophagy

description: Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy.


name: positive regulation of metalloendopeptidase activity

description: Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity.


name: regulation of translation at synapse, modulating synaptic transmission

description: Any process that modulates synaptic transmission by regulating translation occurring at the synapse.


name: negative regulation of protein monoubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination.


name: regulation of translation in response to osmotic stress

description: Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


name: negative regulation of N-terminal peptidyl-lysine acetylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation.


name: positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.


name: negative regulation of N-terminal protein palmitoylation

description: Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein.


name: positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

description: Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


name: regulation of anaphase-promoting complex-dependent catabolic process

description: Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.


name: positive regulation of protein desumoylation

description: Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


name: negative regulation of lysosomal protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.


name: negative regulation of aspartic-type peptidase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity.


regulation of urea metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea.


name: negative regulation of proteoglycan biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


name: negative regulation of urea catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process.


negative regulation of CD86 production

description: Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process.


name: negative regulation of peptidyl-tyrosine autophosphorylation

description: Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


name: negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.


name: regulation of peptide hormone processing

description: Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone.


name: male pseudohermaphroditism due to defective lh molecule


sodium ion uniporter activity

description: Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


name: membrane potential driven uniporter activity

description: Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


phosphate ion uniporter activity

description: Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


L-glutamate uniporter activity

description: Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


potassium ion uniporter activity

description: Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


purine nucleotide uniporter activity

description: Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


name: envenomation resulting in myocyte killing in another organism

description: A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism.


Hard Palate Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the hard palate.  It usually presents as a papillary or exophytic mass.


Squamous cell carcinoma of palate

description: A squamous cell carcinoma that arises from the hard or soft palate.


name: sodium:iodide symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).


sebaceous gland neoplasm

description: A benign or malignant neoplasm that arises from the sebaceous glands. Representative examples include sebaceous adenoma and sebaceous carcinoma.


sebaceous gland cancer

description: A cancer that involves the sebaceous gland.


benign neoplasm of sebaceous gland

description: A benign neoplasm that involves the sebaceous gland.


description: Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate.


Gastric Granular Cell Tumor

description: A benign or malignant granular cell tumor that arises from the stomach.


Benign Gastric Granular Cell Tumor

description: A granular cell tumor that arises from the stomach and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


TARP syndrome

description: A rare developmental defect during embryogenesis syndrome characterized by Robin sequence (micrognathia, glossoptosis, and cleft palate), atrial septal defect, persistence of the left superior vena cava, and talipes equinovarus. The phenotype is variable, some patients present with further dysmorphic characteristics (e.g. hypertelorism, ear abnormalities) while others do not have any key findings. Additional features, such as syndactyly, polydactyly, or brain anomalies (e.g. cerebellar hypoplasia), have also been reported. The syndrome is almost invariably lethal with affected males either dying prenatally or living just a few months.


protein-phytochromobilin linkage

description: The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin.


name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine

description: The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine.


tRNA-dihydrouridine16 synthase activity

description: Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H.


Stage IV Penile Cancer AJCC v6

description: Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades other adjacent structures.  N3: Metastasis in deep inguinal or pelvic lymph node(s) unilateral or bilateral.  M1: Distant metastasis.  (AJCC 6th ed.)


Penile Cancer by AJCC v6 Stage

description: A term that refers to the staging of penile carcinoma according to the American Joint Committee on Cancer, 6th edition.


Stage III Penile Cancer AJCC v6

description: Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0).  T1: Tumor invades subepithelial connective tissue.  T2: Tumor invades corpus spongiosum or cavernosum.  T3: Tumor invades urethra or prostate.  N0: No regional lymph node metastasis.  N1: Metastasis in single superficial, inguinal lymph node. N2: Metastasis in multiple or bilateral superficial inguinal lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.)


Stage I Penile Cancer AJCC v6

description: Stage I includes: (T1, N0, M0).  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


Stage II Penile Cancer AJCC v6

description: Stage II includes: (T1, N1, M0); (T2, N0, M0); (T2, N1, M0).  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  N1: Metastasis in a single superficial, inguinal lymph node.  M0: No distant metastasis. (AJCC 6th ed.)


Stage 0 Penile Cancer AJCC v6

description: Stage 0 includes: (Tis, N0, M0) and (Ta, N0, M0).  Tis: Carcinoma in situ.  Ta: Non-invasive verrucous carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)


beta-heterochromatin

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization.


name: spindle pole body-nuclear membrane anchor activity

description: The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body.


antebrachial lymph node

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


acute cholinergic dysautonomia

description: A primary dysautonomia characterized by hypohidrosis and selective parasympathetic peripheral autonomic nerve disturbances of acute onset.


primary dysautonomia

description: Disorders of the autonomic nervous system occurring as a primary condition. Manifestations can involve any or all body systems but commonly affect the blood pressure and heart rate.


name: selenite:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).


cellular response to vitamin B6

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


response to vitamin B6

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity

description: Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP.


chromosome 17p deletion

description: A cytogenetic abnormality that refers to the allelic loss of all or part of the short arm of chromosome 17.


distal 17p13.3 microdeletion syndrome

description: Distal 17p13.3 microdeletion syndrome is a rare partial monosomy of the short arm of chromosome 17 with a variable phenotype characterized by prenatal and postnatal growth retardation, developmental delay, mild intellectual disability, macrocephaly, mild facial dysmorphisms including prominent forehead, hypertelorism, thick upper and/or lower lip vermillion, and structural abnormalities of the brain variably including white matter abnormalities, prominent Virchow-Robin spaces, Chiari I malformation, corpus callosum hypoplasia, but no lissencephaly.


chromosome 17q12 deletion syndrome

description: 17q12 microdeletion syndrome is a rare chromosomal anomaly syndrome resulting from the partial deletion of the long arm of chromosome 17 characterized by renal cystic disease, maturity onset diabetes of the young type 5, and neurodevelopmental disorders, such as cognitive impairment, developmental delay (particularly of speech), autistic traits and autism spectrum disorder. Mullerian aplasia in females, macrocephaly, mild facial dysmorphism (high forehead, deep set eyes and chubby cheeks) and transcient hypercalcaemia have also been reported.


distal 17p13.1 microdeletion syndrome

description: Distal 17p13.1 microdeletion syndrome is a rare chromosomal anomaly syndrome characterized by mild global developmental delay/intellectual disability with poor to absent speech, dysmorphic features (long midface, retrognathia with overbite, protruding ears), microcephaly, failure to thrive, wide-based gait and a body posture with knee and elbow flexion and hands held in a midline.


name: chromosome 17q23.1-q23.2 deletion syndrome

description: 17q23.1q23.2 microdeletion syndrome is a recently described syndrome characterized by developmental delay, microcephaly, short stature, heart defects and limb abnormalities.


name: Koolen-de Vries syndrome due to 17q21.31 microdeletion syndrome


name: chromosome 17q11.2 deletion syndrome, 1.4Mb

description: A rare severe form of neurofibromatosis type 1 (NF1) characterized by mild facial dysmorphism, developmental delay, intellectual disability, increased risk of malignancies, and a large number of neurofibromas.


name: partial deletion of the long arm of chromosome 17


name: hereditary neuropathy with liability to pressure palsies

description: Hereditary neuropathy with liability to pressure palsies (HNPP) is an inherited peripheral nerve disorder characterized by recurrent mononeuropathy usually triggered by minor physical activities.


distal monosomy 17q

description: Distal monosomy 17q is a very rare chromosomal disorder of unknown prevalence characterized by multiple craniofacial (microcephaly and eye, ear, and nose deformities), limb and other multiple organ abnormalities, growth and motor retardation and intellectual deficit. The syndrome is frequently lethal. The deletions include 17(q21.3q23), 17(q21.3q24.2), 17(q23.q24.3) and 17(q23.1q24.2).


17q24.2 microdeletion syndrome

description: A rare, genetic, multiple congenital anomalies/dysmorphic features-intellectual disability syndrome characterized by developmental and speech delay, intellectual disability, feeding difficulties, failure to thrive, growth retardation, and associated malformations such as abnormality of fingers and toes (i.e. clinodactyly of the 5th finger, 2-3 toe syndactyly), microcephaly, heart defects, and upper airways anomalies. Observed facial dysmorphism includes hypertelorism, small, narrow or downslanting palpebral fissures, ptosis, epicanthus, ear malformations, broad nasal bridge, bulbous/prominent nose, short philtrum, thin lips, retrognathia/micrognathia, arched/cleft palate, and dental anomalies. Additional variable manifestations include hearing and visual impairment, seizures, joint anomalies, obesity, and behavioral/psychiatric disorders.


inherited cutis laxa

description: An instance of cutis laxa that is inherited.


cutis laxa, autosomal dominant 1

description: Any autosomal dominant cutis laxa in which the cause of the disease is a mutation in the ELN gene.


autosomal recessive cutis laxa type 2

description: A spectrum of connective tissue disorders characterized by the association of wrinkled, redundant and sagging inelastic skin with growth and developmental delay, and skeletal anomalies. The spectrum ranges from patients with classic ARCL2 (ARCL, Debre) type) to patients with a milder form of the disease, wrinkled skin syndrome (WSS).


ALDH18A1-related de Barsy syndrome

description: ALDH18A1-related De Barsy syndrome combines intellectual deficit, bilateral cataracts, and skin and joint hyperlaxity.


cutis laxa, autosomal dominant 3

description: An autosomal dominant cutis laxa characterized by thin skin with visible veins and wrinkles, cataract or corneal clouding, clenched fingers, pre- and postnatal growth retardation, moderate intellectual disability, and a combination of muscle hypotonia with brisk muscle reflexes that has material basis in heterozygous mutation in the ALDH18A1 gene on chromosome 10q24.


occipital horn syndrome

description: Occipital horn syndrome (OHS) is a mild form of Menkes disease (MD), a syndrome characterized by progressive neurodegeneration and connective tissue disorders due to a copper transport defect.


name: cutis laxa, autosomal recessive, type 2E


wrinkly skin syndrome

description: A type of cutis laxa that is characterized by wrinkling of the skin of the dorsum of the hands and feet, an increased number of palmar and plantar creases, wrinkled abdominal skin, multiple skeletal abnormalities (joint laxity and congenital hip dislocation), late closing of the anterior fontanel, microcephaly, pre- and postnatal growth retardation, developmental delay and facial dysmorphism (a broad nasal bridge, downslanting palpebral fissures and hypertelorism).


acquired cutis laxa

description: An instance of cutis laxa that is acquired during the lifetime of the individual.


name: cutis laxa, autosomal recessive, type 1B

description: An autosomal recessive cutis laxa type I characterized by disturbed elastic fiber formation resulting in severe systemic connective tissue abnormalities that has material basis in homozygous or compound heterozygous mutation in the EFEMP2 gene on chromosome 11q13.


geroderma osteodysplastica

description: Geroderma osteodysplastica (GO) is characterized by lax and wrinkled skin (especially on the dorsum of the hands and feet and abdomen), progeroid features, hip dislocation, joint laxity, severe short stature/dwarfism, severe osteoporosis, vertebral abnormalities and spontaneous fractures, and developmental delay and mild intellectual deficit.


name: cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies

description: A autosomal recessive cutis laxa type I that has material basis in homozygous or compound heterozygous mutation in the LTBP4 gene on chromosome 19q13


craniofaciofrontodigital syndrome

description: Craniofaciofrontodigital is a rare multiple congenital anomalies syndrome characterized by mild intellectual disability, short stature, cardiac anomalies, mild dysmorphic features (macrocephaly, prominent forehead, hypertelorism, exophthalmos), cutis laxa, joint hyperlaxity, wrinkled palms and soles and skeletal anomalies (sella turcica, wide ribs and small vertebral bodies).