Machado-Joseph disease

description: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common subtype of type 1 autosomal dominant cerebellar ataxia (ADCA type 1), a neurodegenerative disorder, and is characterized by ataxia, external progressive ophthalmoplegia, and other neurological manifestations.


Machado-Joseph disease type 4

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A subtype of Machado-Joseph disease characterized by Parkinsonian symptoms that respond particularly well to levodopa treatment.


Machado-Joseph disease type 3

description: Machado-Joseph disease type 3 is a subtype of Machado-Joseph disease (SCA3/MJD) of milder severity characterized by late onset, slower progression, and peripheral amyotrophy.


Machado-Joseph disease type 5

description: A subtype of Machado-Joseph disease characterized by resemblance to Hereditary Spastic Paraplegia; however, more research is needed to conclude the relationship between Type V MJD and hereditary spastic paraplegia.


Machado-Joseph disease type 1

description: Machado-Joseph disease type 1 is a rare, usually severe subtype of Machado-Joseph disease (SCA3/MJD) characterized by the presence of marked pyramidal and extrapyramidal signs.


proximal superior pancreatic lymph node

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Superior pancreatic lymph node located along the proximal segment of splenic artery.


name: Steroid Resistant Gastrointestinal Tract Acute Graft Versus Host Disease

description: Acute graft versus host disease occurring in the gastrointestinal tract that is resistant to treatment with steroids.


CGG codon-amino acid adaptor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A triplet codon-amino acid adaptor activity that recognizes a CGG codon.


parotid disorder

description: A disease involving the parotid gland.


parotid gland neoplasm

description: A neoplasm (disease) that involves the parotid gland.


benign neoplasm of parotid gland

description: A benign neoplasm that involves the parotid gland.


inosine salvage

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis.


Shock From Lead

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Unintended electric shock from patient leads.


name: positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

description: Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.


name: positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis

description: Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron.


name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

description: Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros.


name: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

description: Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.


name: positive regulation of somatic stem cell population maintenance

description: Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance.


name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

description: Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.


name: positive regulation of single-species biofilm formation on inanimate substrate

description: Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate.


disseminated nephrocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


nephrocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


garland nephrocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


ectopic Cushing syndrome

description: Cushing syndrome due to ectopic (adrenocorticotropic hormone) ACTH secretion (EAS) is a form of ACTH-dependent Cushing syndrome caused by excess secretion of ACTH by a benign or, more often, malignant non-pituitary tumor.


name: ACTH-independent adrenal Cushing syndrome, somatic


name: ACTH-independent macronodular adrenal hyperplasia 1


name: Cushing syndrome due to macronodular adrenal hyperplasia

description: A rare type of Cushing syndrome (CS) characterized by nodular enlargement of both adrenal glands (multiple nodules above 1 cm in diameter) that produce excess cortisol and features of adrenocorticotropic hormone (ACTH) independent CS.


name: ACTH-independent macronodular adrenal hyperplasia 2

description: Any Cushing syndrome due to macronodular adrenal hyperplasia in which the cause of the disease is a mutation in the ARMC5 gene.


name: Cushing syndrome due to cortisol-producing adrenocortical adenoma


ACTH-dependent Cushing syndrome

description: Adrenocorticotropic hormone dependent Cushing syndrome (ACTH-dependent CS) is a form of endogenous CS caused by abnormal production of ACTH due, in 80% of cases, to ACTH oversecretion by a pituitary adenoma (Cushing disease, CD) and in 20% of cases to ectopic ACTH secretion (CS due to EAS) by an extrapituitary tumor (in 50% of cases originating in the lungs or less commonly in the thymus, pancreas, adrenal gland or thyroid) or very rarely due to a tumor secreting both ACTH and corticotrophin-releasing hormone (CRH).


ACTH-independent Cushing syndrome

description: Adrenocorticotropic hormone (ACTH) independent Cushing syndrome is a form of endogenous Cushing syndrome (CS) that may result from excess secretion of cortisol by either a unilateral and benign (adrenocortical adenoma: 55-60%) or malignant (adrenocortical carcinoma: 35-40 %) adrenocortical tumor or by bilateral adrenal secretion by macronodular adrenal hyperplasia (AIMAH), as an isolated disease or as part of McCune-Albright syndrome (MAS), or by primary pigmented nodular adrenocortical disease (PPNAD), as an isolated disease or as part of Carney complex (CNC).


name: intracellular sodium-activated potassium channel activity

description: Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification.


name: mechanosensitive potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress.


name: chloride-activated potassium channel activity

description: Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.


name: G-protein gated potassium channel activity

description: A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer.


name: mitochondrial ATP-gated potassium channel activity

description: Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane.


name: voltage-gated potassium channel activity involved in SA node cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: voltage-gated potassium channel activity involved in SA node cell action potential depolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: intermediate conductance calcium-activated potassium channel activity

description: Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


name: open rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration.


name: voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential

description: Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential.


name: voltage-gated potassium channel activity involved in AV node cell action potential repolarization

description: Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: aldehyde dehydrogenase (quinone) activity

description: Catalysis of the reaction: a quinone + an aldehyde + H2O = a carboxylate + a quinol + H+.


extrahepatic bile duct

description: Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct.


Hilar Portion of the Left Hepatic Duct

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The segment of the left hepatic duct located in the hilum of the liver.


Distal Common Bile Duct

description: The section of the tube-like structure carrying bile that is closest to the intestine and furthest from the hepatic and cystic ducts.


cystic duct

description: The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct.


hilar portion of hepatic duct

description: The segment of either hepatic duct located in the hilum of the liver.


Hilar Portion of the Right Hepatic Duct

description: The segment of the right hepatic duct located in the hilum of the liver.


Distal 1/3 of the Common Bile Duct

description: One third of the tube-like structure carrying bile that is closest to the intestine and furthest from the hepatic and cystic ducts.


name: microphthalmia, isolated, with coloboma 4


description: Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP.


Hemoglobin SE disease

description: A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin E mutations. Patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin SS disease.


name: Stage IV Colorectal Neuroendocrine Tumor AJCC v8

description: Stage IV includes: (T1, Any N, M1); (T2, Any N, M1); (T3, Any N, M1); (T4, Any N, M1). T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. M1: Distant metastasis. (AJCC 8th ed.)


name: Stage IV Colon Neuroendocrine Tumor AJCC v8


name: Stage IV Rectal Neuroendocrine Tumor AJCC v8


detection of endogenous biotic stimulus

description: The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal.


Pyogenic granuloma of oral mucosa

description: A lobular hemangioma arising from the oral mucosa.


Airway Infantile Hemangioma

description: A rare infantile hemangioma in the airway, usually in the subglottic area or trachea. It may or may not be associated with cutaneous lesions. It is a potentially life-threatening condition and the infant should be closely monitored for signs of airway disease.


Senile hemangioma of lip

description: A capillary hemangioma arising from the lip and presenting as a papular lesion.


name: Pyogenic granuloma of skin and subcutaneous tissue

description: A lobular hemangioma arising from the skin and attached subcutaneous tissues.


Anastomosing hemangioma

description: An unusual variant of capillary hemangioma. It is characterized by a unique anastomosing sinusoidal-like architecture which may mimic angiosarcoma. It was originally described in the kidney but rare cases have been reported in other sites.


Infantile hemangioma of liver

description: A capillary hemangioma that arises from the liver. It occurs in infants and children.


Infantile hemangioma

description: A capillary hemangioma that may regress spontaneously.  It occurs in infants and children.


Multiple Lobular Capillary Hemangiomas

description: A lobular hemangioma present in multiple anatomic sites.


Capillary hemangioma of orbit

description: A capillary hemangioma arising from the orbit.


Cardiac Capillary Hemangioma

description: A capillary hemangioma arising from the heart.


secondary neoplasm

description: A neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment.


name: metastatic malignant neoplasm in the colon

description: The spread of a malignant neoplasm to the colon. This may be from a primary large intestine malignant neoplasm, or from a malignant neoplasm at a distant site.


neoplastic meningitis

description: Metastatic neoplasm in which the tumor cells spread to leptomeninges (pia and arachnoid) and subarachnoid space. The most common primary tumors metastasizing to the leptomeninges are breast and lung carcinomas, melanoma, aggressive non-Hodgkin lymphoma, and acute lymphocytic leukemia.


name: metastatic malignant neoplasm in the eye

description: A malignant neoplasm that has spread to the eye from another anatomic site.


metastatic malignant neoplasm

description: A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site.


Foreign body in penis

description: Extraneous material located within the penis.


Postoperative shock

description: A state of shock following a surgical operation.


name: Stage II Appendix Neuroendocrine Tumor AJCC v7

description: Stage II includes: T2, T3, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm or with extension to the cecum. T3: Tumor more than 4 cm or with extension to the ileum.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


Adult Ependymoma

description: An ependymoma occurring in adults.


name: Adult Supratentorial Ependymoma ZFTA Fusion-Positive

description: A supratentorial ependymoma ZFTA fusion-positive that occurs in adults.


Adult Posterior Fossa Ependymoma

description: A posterior fossa ependymoma that occurs in adults.


name: hereditary continuous muscle fiber activity

description: Hereditary continuous muscle fiber activity is a rare, non-dystrophic myopathy characterized by generalized myokymia and increased muscle tone associated with delayed motor milestones, leg stiffness, spastic gait, hyperreflexia and Babinski sign. Symptoms may be worsened by febrile illness or anesthesia.


Advanced Genitourinary System Carcinoma

description: A genitourinary system carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Bladder Urothelial Carcinoma

description: Bladder urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Urethral Urothelial Carcinoma

description: A urethral urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Vaginal Adenosquamous Carcinoma

description: Vaginal adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Endometrial Carcinoma

description: An endometrial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment.


Advanced Ureter Urothelial Carcinoma

description: Ureter urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Penile Carcinoma

description: Penile carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Cervical Carcinoma

description: A cervical carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Platinum-Refractory Ovarian Carcinoma

description: Platinum-refractory ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Bladder Carcinoma

description: A bladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Platinum-Resistant Ovarian Carcinoma

description: Platinum-resistant ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Ovarian Carcinoma

description: An ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Urothelial Carcinoma

description: Urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Renal Pelvis and Ureter Urothelial Carcinoma

description: Renal pelvis and ureter urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Microsatellite Stable Ovarian Carcinoma

description: Microsatellite stable ovarian carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Microsatellite Stable Endometrial Carcinoma

description: Microsatellite stable endometrial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vaginal Carcinoma

description: Vaginal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Endometrial Undifferentiated Carcinoma

description: Endometrial undifferentiated carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Vulvar Carcinoma

description: Vulvar carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Advanced Prostate Carcinoma

description: A prostatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Vaginal Squamous Cell Carcinoma, Not Otherwise Specified

description: Vaginal squamous cell carcinoma, not otherwise specified that that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Advanced Cervical Adenosquamous Carcinoma

description: Cervical adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: posterior lateral line system development

description: The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance.


name: basal ganglia calcification, idiopathic, 1

description: An autosomal dominant condition caused by mutation(s) in the SLC20A2 gene, encoding sodium-dependent phosphate transporter 2. It is characterized by calcification of the basal ganglia.


tert-butanol 2-monooxygenase activity

description: Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol.


Recurrent Lymphomatoid Granulomatosis

description: The reemergence of lymphomatoid granulomatosis after a period of remission.


name: Recurrent Grade II Lymphomatoid Granulomatosis

description: The reemergence of grade II lymphomatoid granulomatosis after a period of remission.


name: Recurrent Grade I Lymphomatoid Granulomatosis

description: The reemergence of grade I lymphomatoid granulomatosis after a period of remission.


name: Recurrent Childhood Lymphomatoid Granulomatosis

description: The reemergence of lymphomatoid granulomatosis in childhood after a period of remission.


retinitis pigmentosa 2

description: Any retinitis pigmentosa in which the cause of the disease is a mutation in the RP2 gene.


RP2-related retinopathy

description: A retinopathy caused by variants in the X-linked gene, RP2.


name: Extraocular Cutaneous Sebaceous Carcinoma

description: A rare variant of sebaceous carcinoma that does not affect the ocular region.


Conjunctival Sebaceous Carcinoma

description: A rare sebaceous carcinoma that arises from the conjunctiva.


Metastatic Sebaceous Carcinoma

description: Sebaceous carcinoma that has spread from the original site of growth to other anatomic sites.


Recurrent Sebaceous Carcinoma

description: The reemergence of sebaceous carcinoma after a period of remission.


sebaceous carcinoma of salivary gland

description: A rare sebaceous carcinoma that arises from the salivary glands.


Refractory Sebaceous Carcinoma

description: Sebaceous carcinoma that is resistant to treatment.


Head and Neck Sebaceous Carcinoma

description: A sebaceous carcinoma that arises from the head and neck region.


distal early tubule

description: Portion of the renal tubule which is just posterior to the proximal straight tubule.


Tropical Disease

description: Infectious and parasitic diseases endemic in tropical and subtropical zones, including Chagas' disease, leishmaniasis, leprosy, malaria, onchocerciasis, schistosomiasis, sleeping sickness, yellow fever, and others; often water- or insect-borne.


infection by Trypanosoma gambiense

description: Trypanosomiasis caused by infection by Trypanosoma brucei gambiense.


early yaws

description: Early yaws includes primary and secondary stages of yaws, endemic tropical treponemal nonvenereal infection: development of initial lesion at inoculation site followed by widespread dissemination of treponemes and generalized secondary granulomatous lesions that may relapse repeatedly.


infection by Trypanosoma rhodesiense

description: An infection with Trypanosoma brucei rhodesiense.


late yaws

description: Late yaws is the tertiary, non-contagious stage of yaws, endemic tropical treponemal nonvenereal infection. Late yaws is characterized by destructive and deforming lesions of the skin, bones, and joints.


yaws

description: An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease.


peripheral lymph node

description: The lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes.


pectoral axillary lymph node

description: An axiallary lymph node along the lower border of the Pectoralis minor, in relation with the lateral thoracic artery. Their afferents drain the skin and muscles of the anterior and lateral thoracic walls, and the central and lateral parts of the mamma; their efferents pass partly to the central and partly to the subclavicular groups of axillary glands.


apical axillary lymph node

description: An axillary lymph node that is situated partly posterior to the upper portion of the Pectoralis minor and partly above the upper border of this muscle.


submandibular lymph node

description: The submandibular lymph nodes (submaxillary glands in older texts), three to six in number, are placed beneath the body of the mandible in the submaxillary triangle, and rest on the superficial surface of the submaxillary salivary gland. One gland, the middle gland of Stahr, which lies on the external maxillary artery as it turns over the mandible, is the most constant of the series; small lymph glands are sometimes found on the deep surface of the submaxillary salivary glands. The afferents of the submaxillary glands drain the medial palpebral commissure, the cheek, the side of the nose, the upper lip, the lateral part of the lower lip, the gums, and the anterior part of the margin of the tongue. Efferent vessels from the facial and submental glands also enter the submaxillary glands. Their efferent vessels pass to the superior deep cervical glands. [WP,unvetted].


description: The superficial anterior cervical lymph nodes are found in proximity to the anterior jugular vein.


superficial inguinal lymph node

description: A group of 12-20 lymph nodes that lie in the subcutaneous tissue below the inguinal ligament and along the terminal part of the great saphenous vein; they drain the skin and subcutaneous tissue of the lower abdominal wall, perineum, buttocks, external genitalia, and lower limbs.


superficial cervical lymph node

description: A group of nodes lying along the external jugular vein; they drain the skin and superficial structures over the region of the sternocleidomastoid muscle and anterior cervical regions. Efferent vessels drain to the deep cervical lymph nodes. Lymph nodes can be further subdivided into anterior and lateral groupings.


proximal deep inguinal lymph node

description: One of the deep inguinal lymph nodes located in or adjacent to the femoral canal; sometimes mistaken for a femoral hernia when enlarged.


superficial lateral cervical lymph node

description: The superficial lateral cervical lymph nodes are found in proximity to the external jugular vein.


popliteal lymph node

description: The lymph nodes which drain the legs; contained in the popliteal fossa.


subscapular axillary lymph node

description: An axillary lymph node that is placed along the lower margin of the posterior wall of the axilla in the course of the subscapular artery.


axillary lymph node

description: The lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region.


deep inguinal lymph node

description: One of several small inconstant lymph nodes, proximal, intermediate and distal deep to the fascia lata and medial to the femoral vein; they receive lymph from the deep structures of the lower limb, from the glans penis and from superficial inguinal nodes; efferents pass to the external iliac nodes.


central axillary lymph node

description: An axillary lymph node that is imbedded in the adipose tissue near the base of the axilla.


inguinal lymph node

description: The lymph nodes located in the groin area.


olivetolic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of olivetolic acid.


description: The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate.


name: pyruvate biosynthetic process from acetate

description: The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate.


description: The chemical reactions and pathways resulting in the formation of 3-(3-hydroxyphenyl)propanoate.


pantothenate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.


coenzyme B biosynthetic process

description: The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.


D-gluconate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose.


name: para-aminobenzoic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.


ketogluconate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.


leukotriene B4 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


galacturonate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid.


description: The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate.


nicotinate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nicotinate.


name: (R)-mandelate catabolic process to benzoate

description: The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate.


pentalenolactone biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pentalenolactone.


name: (R)-2-hydroxy-alpha-linolenic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of (R)-2-hydroxy-alpha-linolenic acid.


keto-D-gluconate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose.


fumagillin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of fumagillin.


benzylpenicillin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of benzylpenicillin.


name: indoleacetic acid biosynthetic process via tryptophan

description: The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan.


name: D(-)-lactate biosynthetic process from pyruvate

description: The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate.


picolinic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of picolinic acid.


sinapate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate.


mycophenolic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of mycophenolic acid (MPA). MPA is the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893.


name: regulation of fever generation by prostaglandin biosynthetic process

description: Any prostaglandin biosynthetic process process that regulates fever generation.


description: The chemical reactions and pathways resulting in the formation of 4-hydroxyphenylacetate.


L-idonate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose.


indoleacetic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants.


cinnamic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid.


phaseic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA).


jasmonic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative.


penicillin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.


(R)-mevalonic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of (R)-mevalonic acid.


lipoxin B4 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds.


name: cyclic 2,3-bisphospho-D-glycerate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid.


D-glucuronate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate.


biotin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.


salicylic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid.


mandelate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic.


ferulate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate.


name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde

description: The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde.


clavulanic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.


leukotriene A4 biosynthetic process

description: The chemical reactions and pathways resulting in the formation of leukotriene A4.


glycolate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid).


name: butyryl-CoA catabolic process to butyrate

description: The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate.


protein deglycation, glyoxal removal

description: The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein.


name: tryptophan-independent indoleacetic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan.


acetoacetic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.


glucuronate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid.


kynurenic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid.


abscisic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid.


quinate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid.


formate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.


name: methionine catabolic process to 3-methylthiopropanoate

description: The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.


name: acetate biosynthetic process from carbon monoxide

description: The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide.


name: protein deglycation, methylglyoxal removal

description: The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein.


name: 2-dehydro-3-deoxy-D-gluconic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid.


p-cumate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of p-cumate.


name: L(+)-lactate biosynthetic process from pyruvate

description: The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate.


dethiobiotin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms.


methylgallate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid.


mycolic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain.


name: positive regulation of fever generation by prostaglandin biosynthetic process

description: Any prostaglandin biosynthetic process process that positively_regulates fever generation.


aldonic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group.


2-oxobutyrate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2.


butyrate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid.


o-orsellinic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of o-orsellinic acid.


palmitic acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of palmitic acid.


ochratoxin A biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ochratoxin A.


glycyrrhetinate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycyrrhetinate.


early stripe melanocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development).


late stripe melanocyte differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development).


name: chronic lymphoproliferative disorder of NK-cells

description: An Epstein-Barr virus negative disorder with a chronic clinical course affecting predominantly adults and characterized by the proliferation of large granular lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes are not rearranged.


name: autosomal recessive early-onset Parkinson disease 23

description: Any young-onset Parkinson disease in which the cause of the disease is a mutation in the VPS13C gene.


Parkinson disease 17

description: Any Parkinson disease in which the cause of the disease is a mutation in the VPS35 gene.


juvenile onset Parkinson disease 19A

description: Any Parkinson disease in which the cause of the disease is a mutation in the DNAJC6 gene.


Parkinson disease 21

description: Any hereditary late onset Parkinson disease in which the cause of the disease is a mutation in the DNAJC13 gene.


Kufor-Rakeb syndrome

description: Kufor-Rakeb syndrome (KRS) is a rare genetic neurodegenerative disorder characterized by juvenile Parkinsonism, pyramidal degeneration (dystonia), supranuclear palsy, and cognitive impairment.


name: autosomal recessive juvenile Parkinson disease 2

description: A group of disorders which feature impaired motor control characterized by bradykinesia, muscle rigidity; tremor; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see parkinson disease), secondary parkinsonism (see parkinson disease, secondary) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the basal ganglia.


early-onset Parkinson disease 20

description: Any Parkinson disease in which the cause of the disease is a mutation in the SYNJ1 gene.


name: parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development


parkinsonian-pyramidal syndrome

description: A Parkinson's disease that has material basis in mutation in the FBXO7 gene on chromosome 22q12.3.


late-onset Parkinson disease

description: A Parkinson disease that begins after around the age of 50.


autosomal dominant Parkinson disease 8

description: Any Parkinson disease in which the cause of the disease is a mutation in the LRRK2 gene.


name: autosomal recessive early-onset Parkinson disease 7

description: Any Parkinson disease in which the cause of the disease is a mutation in the PARK7 gene.


young-onset Parkinson disease

description: A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.


autosomal dominant Parkinson disease 4

description: A late onset Parkinson disease that has material basis in heterozygous triplication of the alpha-synuclein gene (SNCA) on chromosome 4q22.


autosomal dominant Parkinson disease 1

description: An autosomal dominant subtype of Parkinson disease, caused by mutation(s) in the SNCA gene, encoding alpha-synuclein. Mutation(s) in the SNCA gene are responsible for PARK4 and Lewy body dementia, and have overlapping phenotypes.


name: Parkinson disease 22, autosomal dominant

description: Any Parkinson disease in which the cause of the disease is a mutation in the CHCHD2 gene.


name: autosomal recessive early-onset Parkinson disease 6

description: Any Parkinson disease in which the cause of the disease is a mutation in the PINK1 gene.


name: autosomal recessive Parkinson disease 14

description: A rare neurodegenerative disease usually presenting before the age of 30 and which is characterized by dystonia, L-dopa-responsive parkinsonism, pyramidal signs and rapid cognitive decline.


name: UDP-N-acetylgalactosamine transmembrane transporter activity

description: Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


hymenolepiasis

description: A parasitic infection caused by tapeworms. Most infected individuals do not have symptoms. When symptoms appear, they include diarrhea, abdominal pain, restlessness, and irritability.


cavum principale

description: The largest part of the nasal cavity, containing the olfactory epithelium.


congenital aortic valve insufficiency

description: Dysfunction of the aortic valve characterized by incomplete valve closure that is present at birth.


Heart valve regurgitation

description: Dysfunction of one of the cardiac valves characterized by incomplete valve closure.


Rheumatic tricuspid valve regurgitation

description: Tricuspid valve insufficiency secondary to rheumatic fever.


name: Congenital insufficiency of pulmonary valve

description: Dysfunction of the pulmonary valve characterized by incomplete valve closure that is present at birth.


pyrazolylalanine synthase activity

description: Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O.


name: negative regulation of sorocarp stalk cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


name: positive regulation of sorocarp stalk cell differentiation

description: Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


lateral sinus thrombosis

description: Formation or presence of a blood clot (thrombus) in the lateral sinuses. This condition is often associated with ear infections (otitis media or mastoiditis) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from craniocerebral trauma; brain neoplasms; neurosurgical procedures; thrombophilia; and other conditions. Clinical features include headache; vertigo; and increased intracranial pressure.


intracranial sinus thrombosis

description: Formation or presence of a blood clot (thrombus) in the cranial sinuses, large endothelium-lined venous channels situated within the skull. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe headache; seizure; and other neurological defects.


cavernous sinus thrombosis

description: Formation or presence of a blood clot (thrombus) in the cavernous sinus of the brain. Infections of the paranasal sinuses and adjacent structures, craniocerebral trauma, and thrombophilia are associated conditions. Clinical manifestations include dysfunction of cranial nerves iii, iv, V, and vi, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)


anterior auricular lymph node

description: The preauricular deep parotid lymph nodes (anterior auricular glands or preauricular glands), from one to three in number, lie immediately in front of the tragus. Their afferents drain the lateral surface of the auricula and the skin of the adjacent part of the temporal region; their efferents pass to the superior deep cervical glands.


Arteriovenous fistula stenosis

description: Narrowing of the lumen of an arteriovenous fistula.


name: Triple-Class Refractory Multiple Myeloma

description: Multiple myeloma that is resistant to three classes of therapeutic agents, including proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies.


name: heme B transmembrane transporter activity

description: Enables the transfer of heme B from one side of a membrane to the other.


apocrine sweat gland disorder

description: A disease that involves the apocrine sweat gland.


familial acne inversa

description: An instance of hidradenitis suppurativa that is caused by an inherited modification of the individual's genome.


acne inversa, familial, 3

description: Any familial acne inversa in which the cause of the disease is a mutation in the PSEN1 gene.


acne inversa, familial, 2

description: Any familial acne inversa in which the cause of the disease is a mutation in the PSENEN gene.


apocrine adenoma

description: A benign epithelial neoplasm arising from the apocrine sweat glands. Representative examples include tubular apocrine adenoma and external auditory canal ceruminous adenoma.


apocrine sweat gland cancer

description: A malignant neoplasm involving the apocrine sweat gland.


acne inversa, familial, 1

description: Any familial acne inversa in which the cause of the disease is a mutation in the NCSTN gene.


apocrine sweat gland neoplasm

description: A benign or malignant sweat gland neoplasm with apocrine differentiation. Representative examples include apocrine adenoma, ceruminous adenocarcinoma, and apocrine breast carcinoma.


name: negative regulation of cholangiocyte proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation.


name: regulation of cholangiocyte proliferation

description: Any process that modulates the frequency, rate or extent of cholangiocyte proliferation.


name: negative regulation of nucleoside transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of adenosine transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of purine nucleoside transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of inosine transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Dextrocardia Situs Solitus

description: A congenital heart defect in which the heart is located in the right side and the other organs are in their normal position.


name: negative regulation of octopamine signaling pathway involved in response to food

description: Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food.


name: negative regulation of octopamine signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway.


Recurrent Childhood Pineoblastoma

description: The reemergence of pineoblastoma in childhood after a period of remission.


Trichomonas prostatitis

description: Infection of the prostate gland caused by Trichomonas vaginalis.


name: detection of light stimulus involved in magnetoreception

description: The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field.


name: Blasts 9 Percent or Less of Peripheral Blood White Cells

description: A semi-quantitative microscopic finding indicating that 9 percent or less of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.


name: Renal Tubular Acidosis Associated With Deafness

description: Renal tubular acidosis associated with sensorineural hearing loss, and which is typically associated with recessive mutations.


name: renal tubular acidosis, distal, 4, with hemolytic anemia

description: Distal renal tubular acidosis (dRTA) with anemia is a very rare form of distal renal tubular acidosis (dRTA) characterized by a defect in renal acidification and hereditary hemolytic anemia.


extracellular sequestering of iron ion

description: The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system.


name: Refractory Chronic Myelomonocytic Leukemia

description: Chronic myelomonocytic leukemia that is resistant to treatment.


tRNA-dihydrouridine47 synthase activity

description: Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H.


myosin II light chain binding

description: Binding to a light chain of a myosin II complex.


Wilson-Turner syndrome

description: A very rare genetic disease characterized by intellectual disability, truncal obesity, gynecomastia, hypogonadism, dysmorphic facial features, and short stature.


osteogenesis imperfecta type 12

description: Any osteogenesis imperfecta in which the cause of the disease is a mutation in the SP7 gene.


name: combined immunodeficiency due to DOCK8 deficiency

description: Combined immunodeficiency due to dedicator of cytokinesis 8 protein (DOCK8) deficiency is a form of T and B cell immunodeficiency characterized by recurrent cutaneous viral infections, susceptibility to cancer and elevated serum levels of immunoglobulin E (IgE).


name: caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule.


name: ATP:ATP adenylyltransferase activity

description: Catalysis of the reaction: 2 ATP + H+ = diphosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate.


mediastinum rhabdomyosarcoma

description: A malignant mesenchymal tumor with skeletal muscle differentiation affecting the mediastinum.


name: Acrodysostosis 1 with or without hormone resistance

description: An autosomal dominant skeletal dysplasia caused by mutation(s) in the PRKAR1A gene, encoding cAMP-dependent protein kinase type I-alpha regulatory subunit. It is characterized by short stature, brachydactyly, and characteristic facial features. Resistance to multiple hormones is a common finding.


acrodysostosis

description: Acrodysostosis (ACRDYS) is a rare primary bone dysplasia characterized by severe brachydactyly, peripheral dysostosis with facial dysostosis, nasal hypoplasia, and developmental delay.


name: acrodysostosis 2 with or without hormone resistance

description: Any acrodysostosis in which the cause of the disease is a mutation in the PDE4D gene.


name: positive regulation of branchiomeric skeletal muscle development

description: Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure.


name: positive regulation of extraocular skeletal muscle development

description: Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle.


name: positive regulation of somitomeric trunk muscle development

description: Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle.


cystic artery

description: An artery that supplies oxygenated blood to the cystic duct.


ethmoidal sinus neoplasm

description: A benign or malignant neoplasm that affects the ethmoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of sphenoidal sinus

description: A non-metastasizing neoplasm that arises from the sphenoid sinus.


sphenoidal sinus neoplasm

description: A benign or malignant neoplasm that affects the sphenoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


maxillary sinus neoplasm

description: A benign or malignant neoplasm that affects the maxillary sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of ethmoidal sinus

description: A benign neoplasm that involves the ethmoid sinus.


benign neoplasm of maxillary sinus

description: A benign neoplasm that involves the maxillary sinus.


paranasal sinus cancer

description: A primary or metastatic malignant neoplasm involving the paranasal sinuses.


ethmoid sinus ectopic meningioma

description: An extremely rare meningioma that arises as a primary ectopic tumor in the ethmoid sinus.


frontal sinus neoplasm

description: A benign or malignant neoplasm that affects the frontal sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.


benign neoplasm of frontal sinus

description: A benign neoplasm that involves the frontal sinus.


paranasal sinus lymphoma

description: A lymphoma that arises from the paranasal sinus. Representative examples include diffuse large B-cell lymphoma and extranodal NK/T-cell lymphoma, nasal type.


Carcinoid tumor of the duodenum

description: A well differentiated, low grade neuroendocrine neoplasm that arises from the duodenum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent.


name: RNA polymerase II C-terminal domain phosphoserine binding

description: Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II.


adult germ cell tumor

description: A germ cell tumor that occurs during adulthood.


adult teratoma

description: A teratoma that occurs in an adult.


adult cystic teratoma

description: A cystic teratoma that occurs in an adult.


Paranasal Sinus Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm that arises from the paranasal sinuses.


D-ornithine metabolic process

description: The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.


amyotrophic lateral sclerosis type 11

description: Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the FIG4 gene.


name: RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0).


name: RNA polymerase II CTD heptapeptide repeat P3 isomerase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3).


name: RNA polymerase II CTD heptapeptide repeat P6 isomerase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6).


name: NADH dehydrogenase complex (plastoquinone) assembly

description: The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I.


plus-end directed microtubule sliding

description: The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules.


name: FAD-dependent H3K4me/H3K4me3 demethylase activity

description: Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.


name: histone H3K4me/H3K4me2/H3K4me3 demethylase activity

description: Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


name: positive regulation of NAD+ ADP-ribosyltransferase activity

description: Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


name: negative regulation of NAD+ ADP-ribosyltransferase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity.


ribosylnicotinate kinase activity

description: Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide.


paraflagellar rod assembly

description: The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme.


sperm flagellum assembly

description: The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium).


non-motile cilium assembly

description: The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.


cytosolic ciliogenesis

description: The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm.


name: facioscapulohumeral muscular dystrophy 1

description: Any facioscapulohumeral muscular dystrophy in which the cause of the disease is a mutation in the FRG1 gene.


cellular response to glyceraldehyde

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus.


response to D-galactose

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus.


response to mannose

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus.


response to glyceraldehyde

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus.


cellular response to D-galactose

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus.


cellular response to mannose

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus.


response to rhamnose

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.


cellular response to rhamnose stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.


Gollop-Wolfgang complex

description: Gollop-Wolfgang complex is a very rare malformation characterized by ectrodactyly of the hand and ipsilateral bifurcation of the femur.


Metastatic Salivary Duct Carcinoma

description: Salivary duct carcinoma that has spread from its original site of growth to another anatomic site.


Recurrent Salivary Duct Carcinoma

description: The reemergence of salivary duct carcinoma after a period of remission.


left renal pelvis

description: A renal pelvis that is part of a left ureter.


right renal pelvis

description: A renal pelvis that is part of a right ureter.


metanephric renal pelvis

description: A renal pelvis that is part of a metanephros.


name: Stage I Rectal Neuroendocrine Tumor AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


CIC-DUX4 Sarcoma

description: An undifferentiated, high grade small round cell sarcoma affecting predominantly young adults. It is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and DUX4 gene on chromosome 4. The translocation results in CIC-DUX4, t(4;19)(q35;q13) fusions.


Senile dementia

description: Loss of intellectual abilities in an elderly person, interfering with this person's activities.


adrenomedullin binding

description: Binding to adrenomedullin (AM).


ubiquitin activating enzyme binding

description: Binding to a ubiquitin activating enzyme, any of the E1 proteins.


myosin III binding

description: Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain.


prostaglandin D2 receptor binding

description: Binding to a prostaglandin D2 receptor.


type 2 neuromedin U receptor binding

description: Binding to a type 2 neuromedin U receptor.


leukotriene receptor binding

description: Binding to a leukotriene receptor.


cysteinyl leukotriene receptor binding

description: Binding to a cysteinyl leukotriene receptor.


actin lateral binding

description: Binding to an actin filament along its length.


B1 bradykinin receptor binding

description: Binding to a B1 bradykinin receptor.


SUMO-modified protein reader activity

description: A molecular adaptor that recognizes and binds a target protein containing a SUMO modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.


alpha-1D adrenergic receptor binding

description: Binding to an alpha-1D adrenergic receptor.


name: receptor tyrosine kinase-like orphan receptor binding

description: Binding to a receptor tyrosine kinase-like orphan receptor (Ror).


adipokinetic hormone binding

description: Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


name: glutamate-cysteine ligase catalytic subunit binding

description: Binding to the catalytic subunit of glutamate-cysteine ligase.


name: type 4 proteinase activated receptor binding

description: Binding to a type 4 proteinase activated receptor.


type 6 serotonin receptor binding

description: Binding to a type 6 serotonin receptor.


type 2B serotonin receptor binding

description: Binding to a type 2B serotonin receptor.


interleukin-9 binding

description: Binding to interleukin-9.


name: type 2 metabotropic GABA receptor binding

description: Binding to a type 2 metabotropic GABA receptor.


protein phosphatase 5 binding

description: Binding to protein phosphatase 5.


type 1 cannabinoid receptor binding

description: Binding to a type 1 cannabinoid receptor.


GAF domain binding

description: Binding to a GAF protein domain.


enzyme binding

description: Binding to an enzyme, a protein with catalytic activity.


sevenless binding

description: Binding to a sevenless (sev) protein, a receptor tyrosine kinase.


type-I cohesin domain binding

description: Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain.


complement component C5a binding

description: Binding to a C5a product of the complement cascade.


type 2 somatostatin receptor binding

description: Binding to a type 2 somatostatin receptor.


substance P receptor binding

description: Binding to a substance P receptor.


type A cholecystokinin receptor binding

description: Binding to a type A cholecystokinin receptor.


amylin binding

description: Binding to amylin.


receptor-receptor interaction

description: The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.


name: RNA polymerase II-specific DNA-binding transcription factor binding

description: Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.


complement component iC3b binding

description: Binding to a iC3b product of the complement cascade.


type 2 neuropeptide Y receptor binding

description: Binding to a type 2 neuropeptide Y receptor.


D4 dopamine receptor binding

description: Binding to a D4 dopamine receptor.


alpha-2B adrenergic receptor binding

description: Binding to an alpha-2B adrenergic receptor.


name: TFIIE-class transcription factor complex binding

description: Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


preprotein binding

description: Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.


interleukin-21 binding

description: Binding to interleukin-21.


hemoglobin beta binding

description: Binding to a hemoglobin beta chain.


SOCS family protein binding

description: Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions.


name: MHC class Ib protein binding, via antigen binding groove

description: Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove.


GTP cyclohydrolase binding

description: Binding to a GTP cyclohydrolase.


P2Y10 nucleotide receptor binding

description: Binding to a P2Y10 nucleotide receptor.


P2Y8 nucleotide receptor binding

description: Binding to a P2Y8 nucleotide receptor.


thromboxane A2 receptor binding

description: Binding to a thromboxane A2 receptor.


type-II cohesin domain binding

description: Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain.


type 1 somatostatin receptor binding

description: Binding to a type 1 somatostatin receptor.


name: G protein-coupled histamine receptor binding

description: Binding to a G protein-coupled (metabotropic) histamine receptor.


myosin I tail binding

description: Binding to the tail region of a myosin I heavy chain.


myosin XI tail binding

description: Binding to the tail region of a myosin XI heavy chain.


TIR domain binding

description: Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.


kringle domain binding

description: Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors.


interleukin-26 binding

description: Binding to interleukin-26.


beta-endorphin receptor binding

description: Binding to a beta-endorphin receptor.


interleukin-11 binding

description: Binding to interleukin-11.


type 1B melatonin receptor binding

description: Binding to a type 1B melatonin receptor.


name: type B gastrin/cholecystokinin receptor binding

description: Binding to a type B gastrin/cholecystokinin receptor.


hexon binding

description: Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus.


P2Y6 nucleotide receptor binding

description: Binding to a P2Y6 nucleotide receptor.


name: type 1 cysteinyl leukotriene receptor binding

description: Binding to a type 1 cysteinyl leukotriene receptor.


name: G protein-coupled acetylcholine receptor binding

description: Binding to a G protein-coupled acetylcholine receptor.


denatured protein binding

description: Binding to a denatured protein.


urotensin receptor binding

description: Binding to a urotensin receptor.


name: TFIIA-class transcription factor complex binding

description: Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.


chemokine (C-C motif) ligand 21 binding

description: Binding to chemokine (C-C motif) ligand 21.


neuromedin K receptor binding

description: Binding to a neuromedin K receptor.


glycosylated region protein binding

description: Binding to a glycosylated region of a protein.


ganglioside binding

description: Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues.


V2 vasopressin receptor binding

description: Binding to a V2 vasopressin receptor.


H3 histamine receptor binding

description: Binding to a H3 histamine receptor.


name: type 4 metabotropic glutamate receptor binding

description: Binding to a type 4 metabotropic glutamate receptor.


name: MHC class I protein binding, via antigen binding groove

description: Binding to a major histocompatibility complex class I molecules via the antigen binding groove.


myosin I heavy chain binding

description: Binding to a heavy chain of a myosin I complex.


zf-TRAF domain binding

description: Binding to a TRAF-type zinc finger domain of a protein.


G-protein gamma-subunit binding

description: Binding to a G-protein gamma subunit.


cytoskeletal regulatory protein binding

description: Binding to a protein involved in modulating the reorganization of the cytoskeleton.


name: Edg-6 sphingosine 1-phosphate receptor binding

description: Binding to an Edg-6 sphingosine 1-phosphate receptor.


interleukin-22 binding

description: Binding to interleukin-22.


name: plastid single-subunit type RNA polymerase binding

description: Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


name: TFIIIB-class transcription factor complex binding

description: Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.


C2 domain binding

description: Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes.


cholecystokinin receptor binding

description: Binding to a cholecystokinin receptor.


talin binding

description: Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types.


name: type 2 metabotropic glutamate receptor binding

description: Binding to a type 2 metabotropic glutamate receptor.


name: prolactin-releasing peptide receptor binding

description: Binding to a prolactin-releasing peptide receptor.


glycosylation-dependent protein binding

description: Binding to a protein upon glycosylation of the target protein.


BH1 domain binding

description: Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.


name: EP3 subtype prostaglandin E2 receptor binding

description: Binding to an EP3 subtype prostaglandin E2 receptor.


type III interferon binding

description: Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far.


protein dimerization activity

description: The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.


peptidyl-proline 4-dioxygenase binding

description: Binding to a peptidyl-proline 4-dioxygenase.


name: Edg-4 lysophosphatidic acid receptor binding

description: Binding to an Edg-4 lysophosphatidic acid receptor.


name: mitochondrial single-subunit type RNA polymerase binding

description: Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


chemokine (C-C motif) ligand 7 binding

description: Binding to chemokine (C-C motif) ligand 7.


name: RNA polymerase II complex recruiting activity

description: Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.


MDA-5 binding

description: Binding to MDA-5, a cytoplasmic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.


CH domain binding

description: Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins.


name: cadherin binding involved in cell-cell adhesion

description: Any cadherin binding that occurs as part of the process of cell-cell adhesion.


interleukin-19 binding

description: Binding to interleukin-19.


C-X3-C chemokine binding

description: Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.


collectin binding

description: Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.


secretin receptor binding

description: Binding to a secretin receptor.


RBL family protein binding

description: Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose.


calcitonin binding

description: Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.


neuromedin U receptor binding

description: Binding to one or more specific sites on a neuromedin U receptor.


name: K6-linked polyubiquitin modification-dependent protein binding

description: Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein.


eukaryotic initiation factor 4G binding

description: Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.


interleukin-18 binding

description: Binding to interleukin-18.


P2Y11 nucleotide receptor binding

description: Binding to a P2Y11 nucleotide receptor.


cargo receptor ligand activity

description: The activity of a gene product that interacts with a cargo receptor and initiates endocytosis.


description: Binding to a protein upon phosphorylation of the target protein.


name: type 1 metabotropic GABA receptor binding

description: Binding to a type 1 metabotropic GABA receptor.


type 2C serotonin receptor binding

description: Binding to a type 2C serotonin receptor.


name: melanin-concentrating hormone receptor binding

description: Binding to a melanin-concentrating hormone receptor.


name: Edg-1 sphingosine 1-phosphate receptor binding

description: Binding to an Edg-1 sphingosine 1-phosphate receptor.


name: K11-linked polyubiquitin modification-dependent protein binding

description: Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein.


type 5B serotonin receptor binding

description: Binding to a type 5B serotonin receptor.


name: gonadotropin-releasing hormone receptor binding

description: Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


type 1 neuromedin U receptor binding

description: Binding to a type 1 neuromedin U receptor.


name: platelet activating factor receptor binding

description: Binding to a platelet activating factor receptor.


parathyroid hormone receptor binding

description: Binding to a parathyroid hormone receptor.


name: nuclear mineralocorticoid receptor binding

description: Binding to a nuclear mineralocorticoid receptor.


identical protein binding

description: Binding to an identical protein or proteins.


name: macrophage migration inhibitory factor binding

description: Binding to the cytokine, macrophage migration inhibitory factor.


exogenous protein binding

description: Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein.


name: granulocyte macrophage colony-stimulating factor complex binding

description: Binding to a granulocyte macrophage colony-stimulating factor complex.


corticotropin-releasing hormone binding

description: Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.


pentraxin binding

description: Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.


A2B adenosine receptor binding

description: Binding to an A2B adenosine receptor.


name: cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication

description: Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.


name: bacterial-type RNA polymerase core enzyme binding

description: Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.


name: high molecular weight B cell growth factor receptor binding

description: Binding to a high molecular weight B cell growth factor receptor.


name: TFIIH-class transcription factor complex binding

description: Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


STAT family protein binding

description: Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.


Hsp27 protein binding

description: Binding to Hsp27 proteins, a lightweight heat shock protein.


BIR domain binding

description: Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain.


name: RNA polymerase II C-terminal domain binding

description: Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function.


interleukin-12 alpha subunit binding

description: Binding to the alpha subunit of interleukin-12.


prostacyclin receptor binding

description: Binding to a prostacyclin receptor.


interleukin-13 binding

description: Binding to interleukin-13.


cell adhesion receptor activity

description: The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins.


name: EP2 subtype prostaglandin E2 receptor binding

description: Binding to an EP2 subtype prostaglandin E2 receptor.


somatostatin binding

description: Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin.


fMet-Leu-Phe receptor binding

description: Binding to a fMet-Leu-Phe receptor.


name: MHC class II protein binding, via lateral surface

description: Binding to the lateral surface of major histocompatibility complex class II molecules.


scavenger receptor binding

description: Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.


name: type 6 metabotropic glutamate receptor binding

description: Binding to a type 6 metabotropic glutamate receptor.


name: type 7 metabotropic glutamate receptor binding

description: Binding to a type 7 metabotropic glutamate receptor.


DH domain binding

description: Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.


type 1 orexin receptor binding

description: Binding to a type 1 orexin receptor.


complement component C3d binding

description: Binding to a C3d product of the complement cascade.


translation elongation factor binding

description: Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.


name: single-subunit type RNA polymerase binding

description: Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.


interleukin-27 binding

description: Binding to interleukin-27.


name: TFIIB-class transcription factor binding

description: Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.


type 1B serotonin receptor binding

description: Binding to a type 1B serotonin receptor.


name: Edg-7 lysophosphatidic acid receptor binding

description: Binding to an Edg-7 lysophosphatidic acid receptor.


arrestin family protein binding

description: Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.


dynein light chain binding

description: Binding to a light chain of the dynein complex.


type 1 neurotensin receptor binding

description: Binding to a type 1 neurotensin receptor.


type-III cohesin domain binding

description: Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain.


penicillin binding

description: Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.


name: TFIIIA-class transcription factor binding

description: Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters.


DNA binding domain binding

description: Binding to a protein's DNA binding domain (DBD).


name: ADP-D-ribose modification-dependent protein binding

description: Binding to a protein upon ADP-ribosylation of the target protein.


ciliary neurotrophic factor binding

description: Binding to the cytokine ciliary neurotrophic factor.


orexin receptor binding

description: Binding to an orexin receptor.


zymogen binding

description: Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.


name: EP4 subtype prostaglandin E2 receptor binding

description: Binding to an EP4 subtype prostaglandin E2 receptor.


FYXD domain binding

description: Binding to a FXYD domain.


name: calcium-dependent outer dynein arm binding

description: Binding to an outer dynein arm in the presence of calcium.


interleukin-33 binding

description: Binding to interleukin-33.


triacyl lipopeptide binding

description: Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups.


name: glial cell-derived neurotrophic factor receptor binding

description: A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


GBD domain binding

description: Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.


proctolin receptor binding

description: Binding to a proctolin receptor.


hepatocyte growth factor binding

description: Binding to a hepatocyte growth factor.


H9 melatonin receptor binding

description: Binding to a H9 melatonin receptor.


glucagon receptor binding

description: Binding to a glucagon receptor.