name: positive regulation of eosinophil chemotaxis

description: Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis.


Golgi transport vesicle coating

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles.


atovaquone

A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.


chloride ion homeostasis

description: Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell.


name: sequestering of extracellular ligand from receptor

description: The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.


name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.


name: positive regulation of glial cell migration

description: Any process that activates or increases the frequency, rate or extent of glial cell migration.


cytomegalovirus retinitis

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in aids patients and can cause blindness.


name: negative regulation of collagen biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


anatomical structure regression

description: The developmental process in which an anatomical structure is destroyed as a part of its normal progression.


protein farnesylation

description: The covalent attachment of a farnesyl group to a protein.


anileridine

A piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl)ethyl group.


protein-lipid complex remodeling

description: The acquisition, loss or modification of a protein or lipid within a protein-lipid complex.


Cholestatic liver disease

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: nucleotide-sugar transmembrane transporter activity

description: Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


name: regulation of nuclear-transcribed mRNA poly(A) tail shortening

description: Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


succinate dehydrogenase activity

description: Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.


Decreased lacrimation

description: Abnormally decreased lacrimation, that is, reduced ability to produce tears.


voltage-gated sodium channel activity

description: Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


tryptophanyl-tRNA aminoacylation

description: The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


name: negative regulation of DNA recombination at telomere

description: Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere.


sex determination

description: Any process that establishes and transmits the specification of sexual status of an individual organism.


'de novo' UMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen.


name: double-strand break repair via alternative nonhomologous end joining

description: An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.


name: regulation of wound healing, spreading of epidermal cells

description: Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells.


lipoprotein transport

description: The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


dermatophytosis

description: A common fungal infection of the stratum corneum of the skin, hair, or nails by a dermatophyte. It is characterized by itching, inflammation, redness of the skin, small papular vesicles, central clearing, fissures, scaling, and/or hair loss in the affected area.


V(D)J recombination

description: The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


5'-3' DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.


formaldehyde metabolic process

description: The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent.


name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.


name: negative regulation of nitric oxide biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.


name: regulation of extracellular matrix assembly

description: Any process that modulates the frequency, rate or extent of extracellular matrix assembly.


amino acid import

description: The directed movement of amino acids into a cell or organelle.


name: establishment or maintenance of polarity of embryonic epithelium

description: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo.


name: negative regulation of vascular associated smooth muscle cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.


netrin-activated signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.


animal organ maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.


name: regulation of long-term synaptic potentiation

description: Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.


name: regulation of cell migration involved in sprouting angiogenesis

description: Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.


heparin metabolic process

description: The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


MDA-5 signaling pathway

description: The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.


Necrotizing Arteritis

description: An arteritis characterized by the presence of inflammation and necrosis in the arterial wall.


leukotriene catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.


rRNA 3'-end processing

description: Any process involved in forming the mature 3' end of an rRNA molecule.


name: snRNA transcription by RNA polymerase II

description: The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.


name: positive regulation of protein targeting to membrane

description: Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


pantothenate metabolic process

description: The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.


name: positive regulation of prostaglandin-endoperoxide synthase activity

description: Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.


response to cortisol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.


titin binding

description: Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.


intracellular chloride ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell.


skin morphogenesis

description: The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.


name: P-type proton-exporting transporter activity

description: Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.


DNA replication factor A complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.


CDP-diacylglycerol metabolic process

description: The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis.


peptidyl-lysine monomethylation

description: The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.


regulation of mitochondrial fission

description: Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


name: negative regulation of norepinephrine secretion

description: Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.


name: regulation of non-canonical Wnt signaling pathway

description: Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway.


tau-protein kinase activity

description: Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.


chemokine (C-C motif) ligand 5 binding

description: Binding to chemokine (C-C motif) ligand 5.


name: regulation of neutrophil apoptotic process

description: Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process.


name: regulation of development, heterochronic

description: Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.


name: purine deoxyribonucleoside diphosphate metabolic process

description: The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.


cytokinetic process

description: A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).


polar microtubule

description: Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.


interleukin-13 production

description: The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


cellular response to interleukin-12

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


positive regulation of appetite

description: Any process that increases appetite.


radiculopathy

description: Disease involving a spinal nerve root (see spinal nerve roots) which may result from compression related to intervertebral disk displacement; spinal cord injuries; spinal diseases; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.


name: Abnormality on pulmonary function testing

description: Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.


postherpetic neuralgia

description: Pain that occurs after the disappearance of herpes zoster infection lesions.


ubiquitin-dependent endocytosis

description: Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.


Pharyngeal edema

description: Abnormal accumulation of fluid leading to swelling of the pharynx.


pancreatic insulinoma

description: An insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin.


name: Edg-2 lysophosphatidic acid receptor binding

description: Binding to an Edg-2 lysophosphatidic acid receptor.


vascular wound healing

description: Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


name: positive regulation of CD8-positive, alpha-beta T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.


name: extrinsic component of mitochondrial inner membrane

description: The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


ureter

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs.


name: negative regulation of interleukin-5 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.


pantetheine hydrolase activity

description: Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine.


rhodopsin kinase activity

description: Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin.


mating behavior

description: The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.


B cell costimulation

description: The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.


intravascular large B-cell lymphoma

description: Intravascular large B-cell lymphoma (IVLBCL) is a very rare form of diffuse large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of small blood vessels (especially the capillaries) that most often presents with a wide range of clinical manifestations (as potentially any tissue can be involved), with patients from Western countries more frequently manifesting with neurological and cutaneous symptoms while patients from Asian countries more frequently displaying hepatosplenomegaly and thrombocytopenia. IVLBCL is characterized by an absence of lymphadenopathy, an aggressive clinical course and a poor prognosis.


name: regulation of regulatory ncRNA processing

description: Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing.


decamethonium

A quaternary ammonium ion that is a depolarising muscle relaxant whose structure comprises a decane-1,10-diamine core in which each amino group carries three methyl substituents.


Rab protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal.


Intoxication

description: Disturbances in psychophysiological functions and responses as a result of administration or ingestion of a psychoactive substance.


glycogen granule

description: Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.


Neutrophilia

description: Increased number of neutrophils circulating in blood.


name: isocitrate dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H.


glyoxalase III activity

description: Catalysis of the reaction: methylglyoxal + H2O = D-lactate.


name: mitochondrial electron transport, ubiquinol to cytochrome c

description: The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.


name: nucleoside diphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


heart valve morphogenesis

description: The process in which the structure of a heart valve is generated and organized.


chlormezanone

A 1,3-thiazine that is 1,3-thiazinan-4-one S,S-dioxide in which a hydrogen at position 2 is substituted by a 4-chlorophenyl group and the hydrogen attached to the nitrogen is substituted by methyl. A non-benzodiazepine muscle relaxant, it was used in the management of anxiety and in the treatment of muscle spasms until being discontinued worldwide by its manufacturer in 1996, due to rare but serious cutaneous reactions.


alpha-mannosidase activity

description: Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.


clitoris

description: The small, erectile body located at the anterior end of the vulva.


hemoglobin binding

description: Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


name: negative regulation of sodium ion transmembrane transporter activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.


name: positive regulation of mitochondrial membrane permeability

description: Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.


hemolysis in another organism

description: The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another.


name: positive regulation of mRNA catabolic process

description: Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


sensory system development

description: The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.


dyschromatosis universalis hereditaria

description: A pigmentation disease characterized by reticulate hyper- and hypo-pigmentated macules in a generalized distribution.


name: negative regulation of ryanodine-sensitive calcium-release channel activity

description: Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


Lipoatrophy

description: Localized loss of fat tissue.


DNA cytosine deamination

description: The removal of an amino group from a cytosine residue in DNA, forming a uracil residue.


microtubule minus-end binding

description: Binding to the minus end of a microtubule.


name: cellular response to lipoprotein particle stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus.


name: bile acid transmembrane transporter activity

description: Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.


thyroid hormone metabolic process

description: The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


male germ cell nucleus

description: The nucleus of a male germ cell, a reproductive cell in males.


name: 'de novo' cotranslational protein folding

description: The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.


name: non-arteritic anterior ischemic optic neuropathy

description: An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disk or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates.


name: myoblast differentiation involved in skeletal muscle regeneration

description: The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


Hyperuricosuria

description: An abnormally high level of uric acid in the urine.


name: positive regulation of immune response to tumor cell

description: Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.


metanephric nephron development

description: The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.


clathrin adaptor complex

description: A membrane coat adaptor complex that links clathrin to a membrane.


vitamin B12 deficiency

description: A disease characterized by low serum levels of vitamin B12, either inherited or acquired.


Schmidt-Lanterman incisure

description: Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.


name: cardiac vascular smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers.


primosome complex

description: Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart.


description: The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


anuria

description: Absence of urine output.


Abnormal breath sound

description: An anomalous (adventitious) sound produced by the breathing process.


pole plasm assembly

description: Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.


telencephalon regionalization

description: The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.


Ketosis

description: Presence of elevated levels of ketone bodies in the body.


name: regulation of long-chain fatty acid import across plasma membrane

description: Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: sarcoplasmic reticulum calcium ion transport

description: The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum.


heparin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


regulation of mitochondrial translation

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


description: Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein].


muscle hyperplasia

description: A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ.


name: striated muscle myosin thick filament assembly

description: The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.


lacrimal apparatus

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta.


Anterior chamber flare

description: An abnormal appearance of the beam of light traveling through the anterior chamber of the eye in a slit lamp examination. The flare is produced by an increased concentration of proteins in the aqueous humor in the anterior chamber.


name: phosphatidylinositol bisphosphate phosphatase activity

description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate.


Atg8-family ligase activity

description: Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifier to phosphatidylethanolamine or phosphatidylserine on a membrane.


histone H3K36 demethylase activity

description: Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


galactose binding

description: Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides.


DNA alkylation repair

description: The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases.


name: hereditary thrombophilia due to congenital protein C deficiency

description: Congenital protein C deficiency is an inherited coagulation disorder characterized by deep venous thrombosis symptoms due to reduced synthesis and/or activity levels of protein C.


Sinus operation

category: biolink:Procedure biolink:ActivityAndBehavior biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


PTW/PP1 phosphatase complex

description: A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.


name: monoamine transmembrane transporter activity

description: Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other.


cranial nerve neuropathy

description: A neoplastic or non-neoplastic disorder that affects one of the cranial nerves.


name: regulation of translation initiation in response to endoplasmic reticulum stress

description: Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress.


membrane invagination

description: The infolding of a membrane.


Hematospermia

description: A finding indicating the presence of blood in the semen.


Premature epimetaphyseal fusion

description: Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at each end of a long bone, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.


vaginal neoplasm

description: A benign or malignant neoplasm affecting the vagina. Representative examples of benign neoplasms include squamous papilloma and melanocytic nevus. Representative examples of malignant neoplasms include carcinoma, melanoma, and sarcoma.


sex chromatin

description: Chromatin that is part of a sex chromosome.


name: positive regulation of activation of membrane attack complex

description: Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.


Paraparesis

description: Weakness or partial paralysis in the lower limbs.


pentose metabolic process

description: The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.


intracellular lipid transport

description: The directed movement of lipids within cells.


telomere localization

description: Any process in which a telomere is transported to, and/or maintained in, a specific location.


hyperplasia

description: An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement.


U1 snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a U1 snRNA molecule.


NADP catabolic process

description: The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.


name: RNA polymerase II CTD heptapeptide repeat phosphatase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate.


vertebral artery

description: The first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck.


name: negative regulation of heart contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.


name: regulation of cardiac muscle cell action potential involved in regulation of contraction

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction.


name: structural molecule activity conferring elasticity

description: The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.


protein localization to vacuole

description: A process in which a protein is transported to, or maintained at, a location in a vacuole.


semicircular canal morphogenesis

description: The process in which the anatomical structures of the semicircular canals are generated and organized.


name: positive regulation of epithelial cell proliferation involved in wound healing

description: Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.


sphingolipid mediated signaling pathway

description: The series of molecular signals mediated by a sphingolipid.


zona pellucida receptor complex

description: A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.


CAF-1 complex

description: A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.


cellular response to salt

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.


interleukin-1 production

description: The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.


description: Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2.


name: regulation of nucleotide-excision repair

description: Any process that modulates the frequency, rate or extent of nucleotide-excision repair.


name: regulation of extracellular matrix constituent secretion

description: Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.


name: regulation of anti-Mullerian hormone signaling pathway

description: Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway.


Mullerian duct regression

description: The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.


galanin receptor activity

description: Combining with galanin to initiate a change in cell activity.


name: positive regulation of striated muscle tissue development

description: Any process that activates or increases the frequency, rate or extent of striated muscle development.


name: optic cup formation involved in camera-type eye development

description: The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.


nucleotide-excision repair complex

description: Any complex formed of proteins that act in nucleotide-excision repair.


endothelial microparticle

description: A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell.


stereocilia ankle link

description: A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.


name: positive regulation of triglyceride lipase activity

description: Any process that increases the activity of triglyceride lipase.


megestrol acetate

A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.


L-serine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.


nuclear glucocorticoid receptor binding

description: Binding to a nuclear glucocorticoid receptor.


name: negative regulation of membrane protein ectodomain proteolysis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.


neurofilament cytoskeleton organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins.


Vascular Headaches

description: Headache caused by abnormal functioning of the vascular system.


name: equatorial microtubule organizing center

description: A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.


Pericardial friction rub

description: A pericardial friction rub is a grating, to-and-fro sound that occurs in phase with the heart sounds.


name: polyadenylation-dependent ncRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA.


hypersomnia

description: A sleep disorder characterized by excessive sleepiness.


regulation of lymphocyte anergy

description: Any process that modulates the frequency, rate, or extent of lymphocyte anergy.


nuclear proteasome complex

description: A proteasome found in the nucleus of a cell.


name: isopentenyl diphosphate metabolic process

description: The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids.


GDP-L-fucose metabolic process

description: The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate.


vitamin D3 25-hydroxylase activity

description: Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+.


coronary vasculature morphogenesis

description: The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.


name: ATP-binding cassette (ABC) transporter complex

description: A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.


status epilepticus

description: A life-threatening situation in which the brain is in a continuous state of seizure.


mannose metabolic process

description: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.


Prolonged partial thromboplastin time

description: Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms.


corneal disorder

description: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.


MHC class I receptor activity

description: Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.


name: positive regulation of sequestering of calcium ion

description: Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


eye pigment metabolic process

description: The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.


name: negative regulation of protein exit from endoplasmic reticulum

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum.


neuroblast division

description: The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron.


name: aromatic amino acid transmembrane transporter activity

description: Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.


name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.


protein digestion

description: The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism.


host cell cytoplasm part

description: Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction.


prenylcysteine oxidase activity

description: Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.


name: nitric oxide dioxygenase NAD(P)H activity

description: Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+.


hexitol metabolic process

description: The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule.


interleukin-4 receptor binding

description: Binding to an interleukin-4 receptor.


name: regulation of blood volume by renin-angiotensin

description: The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.


regulation of platelet activation

description: Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.


glucose import

description: The directed movement of the hexose monosaccharide glucose into a cell or organelle.


bruxism

description: Excessive clenching of the jaw and grinding of the teeth.


benzylpenicilloyl polylysine

Poly-L-lysine (n > 40) in which 50-70% of the epsilon-amino groups are substituted with benzylpenicilloyl groups. It is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy.


name: protein folding in endoplasmic reticulum

description: A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).


prostate gland morphogenesis

description: The process in which the anatomical structures of a prostate gland are generated and organized.


peptidoglycan catabolic process

description: The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.


cranial ganglion development

description: The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.


acute necrotizing pancreatitis

description: An acute pancreatitis that is characterized by one or more areas of necrosis in the pancreas with varying degree of involvement of the surrounding tissues or organ systems.


lysosomal lumen acidification

description: Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


pseudouridine synthesis

description: The intramolecular conversion of uridine to pseudouridine within an RNA molecule.


dipeptidyl-peptidase activity

description: Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.


name: planar cell polarity pathway involved in neural tube closure

description: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


CD4 receptor binding

description: Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages.


formestane

A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.


name: positive regulation of protein polyubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.


ketone body metabolic process

description: The chemical reactions and pathways involving ketone body.


name: wound healing involved in inflammatory response

description: The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.


RISC complex

description: A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.


Ketoacidosis

description: Acidosis resulting from accumulation of ketone bodies.


axonal growth cone

description: The migrating motile tip of a growing nerve cell axon.


Conjunctival icterus

description: Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease.


name: fusion of sperm to egg plasma membrane involved in single fertilization

description: The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.


natural killer cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.


pancreatic A cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.


dipeptidase activity

description: Catalysis of the hydrolysis of a dipeptide.


sphingolipid binding

description: Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


muscle cell projection membrane

description: The portion of the plasma membrane surrounding a muscle cell projection.


name: oxidoreductase activity, acting on phosphorus or arsenic in donors

description: Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


pars planitis

description: An inflammatory disorder of the cilliary body in the uvea that affects healthy, younger individuals who are often asymptomatic. It has a long clinical course with relapses and remissions. Symptoms include mildly decreased vision and floaters. It may be associated with autoimmune disorders.


name: positive regulation of NLRP3 inflammasome complex assembly

description: Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.


name: regulation of positive thymic T cell selection

description: Any process that modulates the frequency, rate or extent of positive thymic T cell selection.


name: meiotic metaphase I homologous chromosome alignment

description: A cell cycle process whereby homlogous chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator) by the spindle machinery and centromere/kinetochore arrangement during meiosis I chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division.


name: mannose trimming involved in glycoprotein ERAD pathway

description: The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD).


ciliary transition zone

description: A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.


mRNA transcription

description: The cellular synthesis of messenger RNA (mRNA) from a DNA template.


Dysphasia

description: Impairment of verbal communication skills, often resulting from brain damage.


name: protein localization to plasma membrane raft

description: A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft.


name: negative regulation of respiratory burst

description: Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


myoblast migration

description: The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


name: epithelial cilium movement involved in extracellular fluid movement

description: The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.


telomere maintenance via telomerase

description: The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.


regulation of interleukin-23 production

description: Any process that modulates the frequency, rate, or extent of interleukin-23 production.


name: negative regulation of antigen processing and presentation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.


regulation of phospholipase A2 activity

description: Any process that modulates the activity of the enzyme phospholipase A2.


Kyphosis

description: Exaggerated anterior convexity of the thoracic vertebral column.


name: interneuron migration from the subpallium to the cortex

description: The directed movement of interneurons from the subpallium to the cortex during forebrain development.


S-acetyltransferase activity

description: Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule.


nuclear membrane reassembly

description: The reformation of the nuclear membranes following their breakdown in the context of a normal process.


name: protein localization to paranode region of axon

description: A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.


description: Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine.


protein kinase B binding

description: Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.


Diaper Rash

description: An inflammatory skin condition in the diaper area that may be caused by irritation or infection.


name: interleukin-1 receptor antagonist activity

description: Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.


aspartic-type endopeptidase activity

description: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.


cellular hyperosmotic response

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.


glomerulus morphogenesis

description: The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


name: metanephric glomerular mesangial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state.


name: convergent extension involved in neural plate elongation

description: The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate.


Atrioventricular junctional rhythm

description: An electrocardiographic finding of a rhythm which originates in the AV junction and results in a normal heart rate. It is characterized by retrograde P waves which may be obscured by or may follow the QRS complexes. The QRS complexes may be narrow or may demonstrate aberration. (CDISC)


name: cell migration involved in sprouting angiogenesis

description: The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.


name: negative regulation of mitochondrial depolarization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.


color vision disorder

description: The absence of or defect in the perception of colors.


zona fasciculata of adrenal gland

description: The wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone).


heme catabolic process

description: The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.


angiogenin-PRI complex

description: A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis.


molybdenum ion binding

description: Binding to a molybdenum ion (Mo).


intestinal volvulus

description: Twisting of a loop of bowel that results in intestinal obstruction.


urinary bladder disorder

description: A disease involving the urinary bladder.


name: oxalate transmembrane transporter activity

description: Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.


name: microglial cell activation involved in immune response

description: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


serous membrane

description: Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.


name: CD8-positive, alpha-beta T cell activation

description: The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


name: transforming growth factor beta receptor activity, type II

description: Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor.


regulation of glucocorticoid secretion

description: Any process that modulates the frequency, rate or extent of glucocorticoid secretion.


name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule.


NuRD complex

description: An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.


sperm mitochondrion organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm.


name: mRNA export from nucleus in response to heat stress

description: The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export.


ureter development

description: The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


Anoxia

description: Absence or reduction of oxygen in body tissue.


name: negative regulation of fatty acid biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.


xylulose 5-phosphate metabolic process

description: The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway.


name: negative regulation of fatty acid oxidation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.


ptosis

description: The drooping of the upper eyelid.


name: P-type potassium transmembrane transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).


Nipple Discharge

description: The flow of fluid from the nipple of the breast.


axon extension

description: Long distance growth of a single axon process involved in cellular development.


mannokinase activity

description: Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate.


Decreased systolic blood pressure

description: Abnormal decrease in systolic blood pressure.


Lack of insight

description: Lack of insight (Anosognosia) is a neurological condition in which an individual is unaware of his or her own neurological deficit or psychiatric condition. Anosognosia can be associated with mental illness, dementia, and structural brain lesions and can affect an indviduals's conscious awareness of deficits involving judgment, emotions, memory, executive function, language skills, and motor ability.


name: negative regulation of osteoblast proliferation

description: Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.


inhibin A complex

description: Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit.


regulation of protein kinase C activity

description: Any process that modulates the frequency, rate or extent of protein kinase C activity.


actin filament depolymerization

description: Disassembly of actin filaments by the removal of actin monomers from a filament.


name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage

description: Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.


name: regulation of synaptic vesicle recycling

description: Any process that modulates the frequency, rate or extent of synaptic vesicle recycling.


regulation of icosanoid secretion

description: Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell.


name: positive regulation of collateral sprouting

description: Any process that activates or increases the frequency, rate or extent of collateral sprouting.


name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.


succinyl-CoA metabolic process

description: The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.


ubiquitin activating enzyme activity

description: Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.


AMPylase activity

description: Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins.


name: organ or tissue specific immune response

description: An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.


myelin maintenance

description: The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.


name: RNA N6-methyladenosine methyltransferase complex

description: A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).


oxaliplatin

A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.


name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

description: Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.


glutaminase activity

description: Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.


lumbosacral nerve plexus

description: An arrangement of nerve fibers, running from the spine that travels to the pelvic appendage where it innervates skin and muscle.


name: G protein-coupled acetylcholine receptor activity

description: Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


cyclothiazide

3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema.


Hypoglycemic coma

description: Coma induced by low blood sugar.


response to ozone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.


Pitting Edema

description: Swelling due to excessive accumulation of fluid under the skin defined by a persistent indentation when pressure is applied to the swollen area.  Causes include systemic conditions (e.g., heart failure, liver failure, or kidney failure) and local conditions affecting the extremities.


name: negative regulation of cholesterol biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.


carbonyl reductase (NADPH) activity

description: Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.


Milia

description: Presence of multiple small cysts containing keratin (skin protein) and presenting as tiny pearly-white bumps just under the surface of the skin.


spermatocele

description: A benign testicular cyst that is located in the epididymis, and which contains serous fluid, lymphocytes, spermatozoa, and debris.


name: positive regulation of telomerase catalytic core complex assembly

description: Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly.


Post procedural hemorrhage

description: Bleeding occurring after a medical intervention.


name: non-membrane spanning protein tyrosine phosphatase activity

description: Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.


ocular hypertension

description: Abnormally high intraocular pressure.


protein phosphatase type 1 complex

description: A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.


pre-snoRNP complex

description: A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.


calcinosis

description: Deposition of calcium in the tissues. It may be the result of a metabolic disorder or long-standing infection, or it may be associated with the presence of cancer.


PML body organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).


name: release of sequestered calcium ion into cytosol by endoplasmic reticulum

description: The directed movement of calcium ion from endoplasmic reticulum to cytosol.


name: regulation of peroxisome proliferator activated receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.


mRNA methyltransferase activity

description: Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.


name: Familial hypercholesterolemia - heterozygous


name: regulation of platelet-derived growth factor receptor-beta signaling pathway

description: Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.


AP-1 adaptor complex

description: A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).


name: amino acid:monoatomic cation symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in).


eosinophil degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil.


MIT domain binding

description: Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.


NAD+ binding

description: Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.


name: bundle of His cell to Purkinje myocyte communication

description: The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


myeloid dendritic cell differentiation

description: The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.


name: positive regulation of female gonad development

description: Any process that activates or increases the frequency, rate or extent of female gonad development.


name: kidney interstitial fibroblast differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state.


name: regulation of macrophage apoptotic process

description: Any process that modulates the frequency, rate or extent of macrophage apoptotic process.


name: positive regulation of mast cell degranulation

description: Any process that activates or increases the frequency, rate or extent of mast cell degranulation.


sarcoglycan complex

description: A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.


name: regulation of postsynaptic membrane organization

description: Any process that modulates the frequency, rate or extent of postsynaptic membrane organization.


metanephric tubule morphogenesis

description: The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros.


tioconazole

A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.


musculoskeletal system

description: Anatomical system that consists of the muscular and skeletal systems.


Physiologic warmth

category: biolink:PhysiologicalProcess biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: positive regulation of Golgi to plasma membrane protein transport

description: Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.


name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


guanethidine

A member of the class of  guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.


Thin skin

description: Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.


name: succinate dehydrogenase (quinone) activity

description: Catalysis of the reaction: a quinone + succinate = a quinol + fumarate.


establishment of viral latency

description: A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects.


Hemorrhage of colon

description: Bleeding originating from the colon.


biotin metabolic process

description: The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.


name: Fracture of distal end of radius and ulna


rhythmic synaptic transmission

description: Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit.


name: oocyte anterior/posterior axis specification

description: Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.


rRNA pseudouridine synthesis

description: The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.


septin cytoskeleton

description: The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes.


name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen.


female germ cell nucleus

description: The nucleus of the female germ cell, a reproductive cell in females.


oligodendrocyte apoptotic process

description: Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.


cytoplasmic ubiquitin ligase complex

description: A ubiquitin ligase complex found in the cytoplasm.


troponin C binding

description: Binding to troponin C, the calcium-binding subunit of the troponin complex.


name: positive regulation of intracellular steroid hormone receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


cell-cell adhesion mediated by cadherin

description: The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.


kinetochore binding

description: Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.


name: negative regulation of gene silencing by regulatory ncRNA

description: Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.


succinate transport

description: The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: inorganic cation import across plasma membrane

description: The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol.


cellular response to UV-B

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.


Ragulator complex

description: A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).


butenafine

Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.


endothelin B receptor binding

description: Binding to an endothelin B receptor.


positive regulation of cell maturation

description: Any process that activates or increases the frequency, rate or extent of cell maturation.


EMC complex

description: A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.


minoxidil

A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.


name: antigen processing and presentation via MHC class Ib

description: The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


ectodermal placode development

description: The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.


bubble DNA binding

description: Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.


endosome to pigment granule transport

description: The directed movement of substances from endosomes to pigment granules.


kynurenine metabolic process

description: The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.


name: positive regulation of retrograde protein transport, ER to cytosol

description: Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol.


cell envelope organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present.


Fanconi renotubular syndrome

description: A genetic or acquired disorder characterized by impairment of the function of the proximal tubules of the kidney. It results in decreased reabsorption of electrolytes, glucose, amino acids, and other nutrients.


serine C-palmitoyltransferase activity

description: Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA.


name: mesenchymal cell proliferation involved in ureteric bud development

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development.


myosin tail binding

description: Binding to the tail region of a myosin heavy chain.


hepatocyte proliferation

description: The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.


endometritis

description: An acute or chronic, usually bacterial infectious process affecting the endometrium. It may extend to the myometrium and parametrial tissues. Symptoms include lower abdominal pain, vaginal discharge, and vaginal bleeding.


name: negative regulation of type 2 immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.


normocytic anemia

description: Anemia in which the red blood cell volume is normal.


name: somatic diversification of T cell receptor genes

description: The somatic process that results in the generation of sequence diversity of T cell receptor genes.


water intoxication

description: A condition resulting from the excessive retention of water with sodium depletion.


structural constituent of bone

description: The action of a molecule that contributes to the structural integrity of bone.


name: positive regulation of RIG-I signaling pathway

description: Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.


NLRP1 inflammasome complex

description: An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.


name: methotrexate transmembrane transporter activity

description: Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.


deafness, unilateral

description: A unilateral absence of sensory perception of sound.


determination of dorsal identity

description: Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


phospholipase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.


tetrapyrrole biosynthetic process

description: The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


name: TRAIL-activated apoptotic signaling pathway

description: An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.


name: baroreceptor response to increased systemic arterial blood pressure

description: The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels.


name: post-translational protein targeting to endoplasmic reticulum membrane

description: The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.


vesicle coat

description: A membrane coat found on a coated vesicle.


metanephric renal vesicle formation

description: The developmental process pertaining to the initial formation of the metanephros.


name: immune response-inhibiting cell surface receptor signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of inhibiting an immune response.


name: negative regulation of cytokine production involved in inflammatory response

description: Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.


otosalpingitis

description: An inflammatory disease involving a pathogenic inflammatory response in the pharyngotympanic tube.


essential hypertension

description: Hypertension that presents without an identifiable cause.


integrin alphav-beta5 complex

description: An integrin complex that comprises one alphav subunit and one beta5 subunit.


description: Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.


Abdominal obesity

description: Excessive fat around the stomach and abdomen.


name: positive regulation of cell-cell adhesion mediated by integrin

description: Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin.


name: positive regulation of dense core granule biogenesis

description: Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis.


paronychia

description: An acute or chronic infection of the soft tissues around the nail. Symptoms include pain, tenderness, erythema, and swelling around the nail. Acute infection results from minor trauma to the fingertip and Staphylococcus aureus is usually the causative agent. Chronic infection is usually caused by Candida albicans.


piP-body

description: A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.


name: regulation of follicle-stimulating hormone secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone.


name: regulation of heparan sulfate proteoglycan biosynthetic process

description: Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.


mitral valve development

description: The progression of the mitral valve over time, from its formation to the mature structure.


thyroid gland disorder

description: A disease involving the thyroid gland.


name: chromosome movement towards spindle pole

description: The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes.


name: negative regulation of G0 to G1 transition

description: A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.


name: negative regulation of intracellular estrogen receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


osteomyelitis

description: An acute or chronic inflammation of the bone and its structures due to infection with pyogenic bacteria.


behavioral response to cocaine

description: Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.