name: Pneumonia caused by respiratory syncytial virus

description: Pneumonia that is attributed to the respiratory syncytial virus.


Paracicatricial Emphysema

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The development of dilated terminal airspaces in the lung adjacent to parenchymal scarring.


name: Chronic obstructive asthma (with obstructive pulmonary disease)

description: Chronic airway obstruction caused by asthma.


Pulmonary vascular disorder

description: A category of non-neoplastic disorders that affect the blood vessels in the lungs.  Representative examples include pulmonary embolism, pulmonary hypertension, and arteriovenous malformations.


Steroid-Refractory Pneumonitis

description: Pneumonitis that does not respond to corticosteroid therapy.


Tuberculous bronchiectasis

description: Bronchiectasis that develops in patients with a history of pulmonary tuberculosis.  It is usually associated with healed scars but occasionally may be seen in patients with active pulmonary tuberculosis.


Severe acute respiratory infection

description: A respiratory infectious disorder that leads to an acute illness that requires medical attention.


Stannosis

description: A disorder associated with chronic exposure to inhaled tin oxide dust or fumes.


Severe Bronchopulmonary Dysplasia

description: Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased.


name: Pneumonia caused by methicillin resistant Staphylococcus aureus

description: Pneumonia that is caused by Staphylococcus aureus that is resistant to methicillin treatment.


Cannabinosis

description: A disorder associated with chronic exposure to inhaled dust during the processing of hemp.


Asbestos-Related Lung Disorder

description: A disorder affecting the lungs due to asbestos exposure. Examples include asbestosis and lung carcinoma.


Toxoplasma Pneumonia

description: Pneumonia caused by the parasite Toxoplasma gondii.  It usually presents as an opportunistic infection in immunocompromised patients, especially patients with AIDS.  It is rare in immunocompetent individuals.  Signs and symptoms include cough, fever, and dyspnea.


Secondary Pneumonia

description: A pneumonia that occurs during or following treatment for an acute (primary) pneumonia that was caused by a different organism. It may be the result of increased susceptibility due to the initial treatment.


Pulmonary trunk hypoplasia

description: Underdeveloped pulmonary arteries.


name: Respiratory Failure Related to Central Nervous System Disorder

description: Impaired gas exchange by the respiratory system resulting in hypoxemia and decreased oxygenation of the tissues that may be associated with increased arterial levels of carbon dioxide; the respiratory failure is due to a central nervous system disorder.


name: Autoimmune Pulmonary Alveolar Proteinosis

description: A type of pulmonary alveolar proteinosis associated with low concentrations of GM-CSF.


Sickle Cell Chronic Lung Disease

description: A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present.


Hyaline Membrane Syndrome

description: A serious disorder affecting newborns, particularly premature infants. It is caused by deficiency of surfactant, resulting in the formation of a membrane in the alveoli lining. This membrane contains fibrin and cellular debris and interferes with respiration. Infants with this disorder develop breathing problems immediately or in a few hours after delivery. It may lead to respiratory failure.


Fibrotic Hypersensitivity Pneumonitis

description: Interstitial lung fibrosis resulting from chronic hypersensitivity pneumonitis.


AIDS-Related Pneumocystis Pneumonia

description: A serious AIDS-related opportunistic infection of the lungs, caused by Pneumocystis jirovecii.  It is one of the most common AIDS-related illnesses and is a major cause of morbidity in patients with AIDS.  Signs and symptoms include cough, fever, dyspnea, and pain or tightness in the chest.


Pulmonary Precancerous Condition

description: A premalignant pathologic process that affects the lungs.  This category includes bronchial intraepithelial neoplasia and atypical adenomatous hyperplasia.


Diffuse Panbronchiolitis

description: A clinico-pathologic syndrome primarily affecting the respiratory bronchioles with evidence of inflammation in all layers of the bronchiole. Sinusitis is often an accompanying feature.


hepatopancreas

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An organ of the digestive tract of arthropods and molluscs. It provides the functions which in mammals are provided separately by the liver and pancreas, including the production of digestive enzymes, and absorption of digested food.


arthropod hepatopancreas

description: Digestive gland of crustaceans with functions approximately analogous to liver and pancreas of vertebrates - enzyme secretion, food absorption and storage.


Mesothelial hyperplasia

description: A hyperplasia of the mesothelial cells.


Atypical Mesothelial Hyperplasia

description: An atypical hyperplasia of the mesothelial cells.


Infectious Salpingitis

description: An acute or chronic infectious process affecting the fallopian tube. Chlamydia trachomatis, Neisseria gonorrhea, Mycoplasma, Staphylococcus, and Streptococcus are the most common causative agents.


ovarian vein

description: A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries.


left ovarian vein

description: Ovarian vein, each instance of which is a tributary  of some left renal vein that drains the left pampiniform plexus of some broad ligament.


right ovarian vein

description: Ovarian vein, each instance of which is a tributary  of some inferior vena cava that drains the right pampiniform plexus of some broad ligament.


Other Embryologic Structure

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


metanephros

description: In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO].


pharyngeal pouch 3

description: A pharyngeal pouch that between pharyngeal arches 3 and 4.


neural plate

description: A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].


atrial septum secundum

description: Missing definition for term UBERON:0004155. Please replace it using linked reference.


lung bud

description: Structure derived from foregut that becomes a lung[GO].


subcardinal vein

description: A vein in the mammalian embryo or the adult of some lower vertebrates that is located on each side of the abdominal region ventromedial to the mesonephros and that in mammals participates in the formation of the inferior vena cava and the renal vein.


optic stalk

description: The narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain.


neural fold

description: One of the two elevated edges of the neural groove[GO,MP].


primitive streak

description: The primitive streak is a structure that forms during the early stages of avian, reptilian and mammalian embryonic development[WP]. the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm[MP].


stapedial artery

description: A small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood[MP].


pronephros

description: In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO].


atrial septum primum

description: In the developing heart, the cavity of the primitive atrium becomes subdivided into right and left chambers by a septum, the septum primum, which grows downward into the cavity. The increasingly smaller gap below it (before it fuses with the endocardial cushion) is known as the ostium primum. The septum primum eventually fuses with the endocardial cushion, closing the ostium primum off completely. Meanwhile, perforations appear in the superior part of the septum primum, forming the ostium secundum. This will eventually form part of the fossa ovalis.


vitelline vein

description: The paired veins that carry blood from the yolk sac back to the embryo.


central tendon of diaphragm

description: The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers.


ovary sex cord

description: Structures that develop from sex cords in the female. After further development they become the ovarian follicles.


truncus arteriosus

description: The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles.


periderm

description: The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm.


pharyngeal pouch 1

description: A pharyngeal pouch that is between pharyngeal arches 1 and 2.


embryonic cardiovascular system

description: A cardiovascular system that is part of a conceptus.


sex cord

description: Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female.


ventral mesogastrium

description: Portion of ventral mesentery closest to the stomach.


ductus arteriosus

description: A fetal blood vessel connecting the pulmonary artery with the descending aorta[MESH]. In the developing fetus, the ductus arteriosus is a shunt connecting the pulmonary artery to the aortic arch. It allows most of the blood from the right ventricle to bypass the fetus' fluid-filled lungs, protecting the lungs from being overworked and allowing the left ventricle to strengthen. There are two other fetal shunts, the ductus venosus and the foramen ovale[MP]. the fetal vessel that connects the left pulmonary artery with the descending aorta; the ductus arteriosus normally regresses into a fibrous cord, the ligamentum arteriousum after birth[MP].


dorsal mesogastrium

description: The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum.


indifferent gonad

description: A gonad prior to differentiating into a definitive testis or ovary.


pharyngeal pouch 5

description: A pharyngeal pouch between pharyngeal arches 5 and 6.


somite

description: Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.


nasolacrimal groove

description: Groove between maxillary prominence and lateral nasal process.


pharyngeal pouch

description: An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches.


Embryonic palate

description: The development of the roof of the oral cavity from the fusion of median palatine process to the paired lateral palatine processes, which occurs between the six and twelfth weeks of gestation.


supracardinal vein

description: Either of two veins in the mammalian embryo and various adult lower vertebrate forms located in the thoracic and abdominal regions dorsolateral to and on either side of the descending aorta and giving rise to the azygos and hemiazygos veins and a part of the inferior vena cava[MW]. These veins drain the body wall via the segmental intercostal veins, thus taking over the function of the posterior cardinals[ISBN].


ductus venosus

description: The vascular channel in the fetus passing through the liver and joining the umbilical vein with the inferior vena cava.


pharyngeal arch artery

description: One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].


notochordal plate

description: The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.


pharyngeal pouch 2

description: A pharyngeal puch that is between the pharyngeal arches 2 and 3.


pharyngeal pouch 4

description: A pharyngeal pouch between pharyngeal arch 4 and arch 5 or 6 (a fifth arch never establishes in amniotes).


Conjunctival Rhabdomyosarcoma

description: A rhabdomyosarcoma that arises from the conjunctiva.


mitomycin

A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.


onium betaine

Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


O-acetylcarnitine

An O-acylcarnitine having acetyl as the acyl substituent.


saturated fatty acyl-L-carnitine

An O-acylcarnitine in which the R is a saturated fatty acyl chain.


THIAMIN DIPHOSPHATE

An ammonium betaine that is the conjugate base of thiamine(1+) diphosphate arising from the deprotonation of one of the hydroxy groups of the terminal phosphate group.


O-acylcarnitine

Any carboxylic ester obtained by the O-acylation of carnitine.


thiaminium carboxylate betaine

An ammonium betaine that is the conjugate base of thiamine(1+) carboxylic acid arising from the deprotonation of the carboxy group.


amino-acid betaine

Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms.


fatty acyl-L-carnitine

Any O-acylcarnitine in which the carnitine component has L-configuration and the acyl group is a fatty acid.


CARNITINE

An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4.


thiamine(1+) triphosphate(1-)

An ammonium betaine that is the conjugate base of thiamine(1+) triphosphate arising from the deptoronation of one of the hydroxy groups of the terminal phosphate group.


thiamine(1+) monophosphate(1-)

An ammonium betaine that is the conjugate base of thiamine(1+) monophosphate arising from the deprotonation of one of the phosphate hydroxy groups.


O-acyl-L-carnitine

An O-acylcarnitine in which the carnitine component has L-configuration.


sulfonium betaine

Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


ammonium betaine

Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.


mitochondrial [4Fe-4S] assembly complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex capable of condensing two 2Fe-2S clusters into one 4Fe-4S center in mitochondria. In S. cerevisiae, it consists of Isa1 and Isa2. In humans it consists of ISCA1 and ISCA2. Additional proteins may be present.


iron-sulfur cluster assembly complex

description: A protein complex capable of assembling an iron-sulfur (Fe-S) cluster.


IscS-IscU complex

description: A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consists of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group.


mitochondrial [2Fe-2S] assembly complex

description: A protein complex capable of forming 2Fe-2S clusters in mitochondria. In humans it consists of ISCU, NFS1, LYRM4, NDUFAB1 and FXN.


name: cytosolic [4Fe-4S] assembly scaffold complex

description: A heterotetrameric complex with weak ATPase activity that is capable of scaffolding a 4Fe-4S (iron-sulfur) cluster. In yeast, the subunits are Nbp35 and Cfd1. In humans, the subunits are NUBP1 and NUBP2.


name: crista of ampulla of anterior semicircular duct of membranous laybrinth

description: A crista ampullaris neuroepithelium that is part of a anterior semicircular duct.


crista ampullaris neuroepithelium

description: An epithelium that is part of a crista ampullaris.


name: crista of ampulla of lateral semicircular duct of membranous laybrinth

description: A crista ampullaris neuroepithelium that is part of a lateral semicircular duct.


name: crista of ampulla of posterior semicircular duct of membranous laybrinth

description: A crista ampullaris neuroepithelium that is part of a posterior semicircular duct.


name: Stage IA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT1, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Immature Teratoma

description: An immature teratoma occurring in children.


name: Localized Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Tumor confined to the testes. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Choriocarcinoma

description: A choriocarcinoma occurring in children.


name: Stage III Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, Any N, M1, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Testicular Yolk Sac Tumor, Prepubertal-Type

description: Testicular yolk sac tumor that almost always occurs in pure form and is not associated with germ cell neoplasia in situ. It affects young children and is the most frequently seen testicular neoplasm in prepubertal children.


Childhood Mature Teratoma

description: A mature teratoma occurring in children.


name: Refractory Childhood Malignant Germ Cell Tumor

description: A malignant germ cell tumor that occurs during childhood and is resistant to treatment.


name: Stage IIIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-N3, M0, S3 or Any pT, Any N, M1, S3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-N3, M0, S2 or Any pT, Any N, M1, S2. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Malignant Testicular Germ Cell Tumor

description: A malignant germ cell tumor in children arising from the testis.  It includes the embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mixed germ cell tumors.


name: Recurrent Childhood Malignant Germ Cell Tumor

description: The reemergence of a malignant germ cell tumor in children after a period of remission.


name: Stage IB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT2-4, N0, M0, S0. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Germinomatous Germ Cell Tumor

description: A germinomatous germ cell tumor occurring in children.


Childhood Mixed Germ Cell Tumor

description: A mixed germ cell tumor occurring in children.


name: Stage IIA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage II Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N1-3, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Extracranial Germ Cell Tumor

description: A childhood benign or malignant germ cell tumor arising from an anatomic site other than the brain.


name: Metastatic Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Teratoma

description: A mature or immature teratoma occurring in children.


Childhood Seminoma

description: A seminoma occurring in children.


Childhood Embryonal Carcinoma

description: An embryonal carcinoma occurring in children.


Childhood Extragonadal Teratoma

description: An extragonadal teratoma that occurs during childhood.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 2

description: A term that refers to the staging of childhood testicular germ cell tumor according to the tier 2 Toronto childhood cancer staging guidelines v2.


name: Regional Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Tumor extension to regional lymph nodes: interaortocaval, para-aortic (periaortic), paracaval, preaortic, precaval, retroaortic, retrocaval, and along spermatic cord. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIB Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N2, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Childhood Extragonadal Malignant Germ Cell Tumor

description: A malignant germ cell tumor in children arising from an anatomic site other than the testis or ovary.


name: Childhood Central Nervous System Teratoma

description: A mature or immature teratoma affecting the central nervous system and occurring in children.


Childhood Benign Germ Cell Tumor

description: A germ cell tumor that occurs during childhood and is characterized by the absence of atypia and metastatic potential.


name: Childhood Nongerminomatous Germ Cell Tumor

description: A nongerminomatous germ cell tumor occurring in children.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage, Tier 1

description: A term that refers to the staging of childhood testicular germ cell tumor according to the tier 1 Toronto childhood cancer staging guidelines v2.


name: Childhood Testicular Non-Seminomatous Germ Cell Tumor

description: A non-seminomatous germ cell tumor that arises in the testis and occurs in children.


name: Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood testicular germ cell tumor according to the Toronto childhood cancer staging guidelines v2.


name: Stage IS Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N0, M0, S1-3. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage I Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: pT1-4, N0, M0, SX. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage IIC Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, N3, M0, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Testicular Yolk Sac Tumor

description: A yolk sac tumor that arises from the testis during childhood.


stomach non-glandular epithelium

description: Am epithelium that lines the stomach which lacks glands. In addition to a glandular epithelium, the stomachs of some vertebrates also has a second region characterized by a nonglandular epithelium, devoid of gastric glands.


rumen epithelium

description: The rumen epithelium is the tissue which lines the largest of the four fore stomachs in the ruminant animal -cows and sheep. Rumen epithelial cells are important because they are responsible for the absorption of nutrients from the rumen into the blood.


Intermediate Grade Osteosarcoma

description: An osteosarcoma with intermediate-grade morphological features. A representative example is periosteal osteosarcoma.


name: Peripheral Nervous System Infectious Disorder

description: An infectious process affecting the peripheral nerves.


B-Cell Malignant Neoplasm

description: A clonal lymphoproliferative disorder composed of neoplastic B-cells. It includes B-cell non-Hodgkin lymphomas, B-cell leukemias, and plasma cell myeloma.


Chronic lymphocytic leukemia stage 1

description: Risk: Intermediate; Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


name: Multiple Myeloma with MAF Family Translocation

description: Multiple myeloma characterized by the presence of a translocation involving a MAF family gene.


DS Stage IA Multiple Myeloma

description: Durie/Salmon stage I multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: B Acute Lymphoblastic Leukemia with t(4;11)(q21;23.3); KMT2A-AFF1

description: A B-cell acute lymphoblastic leukemia associated with t(4;11)(q21;23.3). This translocation leads to the generation of the fusion gene KMT2A-AFF1.


name: Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: A B acute lymphoblastic leukemia that occurs during childhood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


name: Hypodiploid B Acute Lymphoblastic Leukemia

description: A B-cell acute leukemia characterized by the presence of lymphoblasts which contain less than 46 chromosomes. It occurs in both children and adults. It has an unfavorable clinical outcome.


Recurrent Chronic Lymphoid Leukemia

description: The reemergence of chronic lymphocytic leukemia after a period of remission.


name: Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

description: Chronic lymphocytic leukemia/small lymphocytic lymphoma that does not respond to treatment.


name: Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

description: The reemergence of chronic lymphocytic leukemia/small lymphocytic lymphoma after a period of remission.


name: Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: B-acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 that is resistant to treatment.


Leptomeningeal myelomatosis

description: A central nervous system multiple myeloma involving the leptomeninges.


name: B Acute Lymphoblastic Leukemia with Recurrent Genetic Abnormalities

description: B-acute lymphoblastic leukemias characterized by the presence of recurring cytogenetic and/or molecular abnormalities.


name: Refractory B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia that does not respond to treatment.


Plasma cell myeloma recurrent

description: The reemergence of multiple myeloma after a period of remission.


DS Stage IIIB Multiple Myeloma

description: Durie/Salmon stage III multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: Recurrent B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: The reemergence of  B-acute lymphoblastic leukemia, BCR-ABL1-like after a period of remission.


name: B Acute Lymphoblastic Leukemia with ETV6-RUNX1-Like Features

description: B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B acute lymphoblastic leukemia, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


name: Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

description: A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed B-lymphocytes or plasma cells. The clonal cellular infiltrates fulfill the criteria for a diffuse large B-cell lymphoma, Burkitt lymphoma, or a plasma cell neoplasm.


name: Recurrent B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: The reemergence of B acute lymphoblastic leukemia, Philadelphia chromosome negative, after a period of remission.


name: Multiple Myeloma, Not Otherwise Specified

description: Multiple myelomas characterized by the absence of recurrent genetic abnormalities.


name: B Acute Lymphoblastic Leukemia, Not Otherwise Specified

description: B-acute lymphoblastic leukemias characterized by the absence of recurrent genetic abnormalities.


name: Extramedullary Disease in Multiple Myeloma Involving the Central Nervous System

description: Multiple myeloma involving the central nervous system. It manifests with single or multiple intraparenchymal lesions and/or leptomeningeal involvement. Patients present with diffuse cerebral dysfunction and nerve paralysis. The prognosis is poor.


Stage A Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


name: Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene

description: Chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.


name: B Acute Lymphoblastic Leukemia with Mutated ZEB2 (p.H1038R)

description: B-acute lymphoblastic leukemia associated with mutations in the ZEB2 gene that encode a histidine to arginine amino acid substitution at codon 1038. This variation appears to phenocopy the IGH-CEBPE gene fusion. This is a provisional entity.


name: Refractory B-Cell Prolymphocytic Leukemia

description: B-cell prolymphocytic leukemia that is resistant to treatment.


name: Chronic Lymphocytic Leukemia- Binet Staging System

description: A term that refers to the staging of chronic lymphocytic leukemia according to Binet staging system. This system is in wide use outside the United States.


Chronic lymphocytic leukemia stage 4

description: Risk: High; Findings: Lymphocytosis and platelets less than 100,000/microliter; Survival (months): 30. (from AJCC 8th Ed.)


name: Cutaneous B Lymphoblastic Leukemia/Lymphoma

description: B-lymphoblastic leukemia/lymphoma that affects the skin.


Recurrent Extraosseous Plasmacytoma

description: The reemergence of extraosseous plasmacytoma after a period of remission.


Recurrent Solitary Plasmacytoma

description: The reemergence of solitary plasmacytoma after a period of remission.


Stage B Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis and adenopathy; Survival (months): 95. (from AJCC 8th Ed.)


name: Multiple Myeloma Post-Transplant Lymphoproliferative Disorder

description: A lymphoproliferative disorder that develops following an organ transplantation and exhibits multiple myeloma features.


name: Multiple Myeloma with Recurrent Genetic Abnormalities

description: Multiple myelomas characterized by the presence of recurring cytogenetic abnormalities.


name: Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder

description: A plasmacytoma-like hematologic malignancy that arises in a patient with a history of organ transplantation.


name: B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Multilineage Involvement

description: B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by both lymphoblastic and differentiating myeloid cell proliferation.


name: B Acute Lymphoblastic Leukemia with Germline IKZF1 Mutation

description: B-acute lymphoblastic leukemia that results from germline mutation of the IKZF1 gene.


Chronic lymphocytic leukemia stage 2

description: Risk: Intermediate; Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


name: Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: A B acute lymphoblastic leukemia that occurs during adulthood. It is characterized by the presence of lymphoblasts that carry a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein. It has an unfavorable clinical outcome.


Refractory B-Cell Malignant Neoplasm

description: A B-cell malignant neoplasm that is resistant to treatment.


name: Multiple Myeloma with CCND Family Translocation

description: Multiple myeloma characterized by the presence of a translocation involving a CCND family gene.


RISS Stage I Multiple Myeloma

description: Serum beta-2-microglobulin less than 3.5 mg/L and serum albumin 3.5 g/dL or more and no high-risk cytogenetics and normal LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


DS Stage IIB Multiple Myeloma

description: Durie/Salmon stage II multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation

description: A chronic lymphocytic leukemia characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology.


name: Near-Haploid B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia associated with a near haploid karyotype.


name: B Acute Lymphoblastic Leukemia with IKZF1 N159Y Mutation

description: B-acute lymphoblastic leukemia associated with IKZF1 missense mutation p.Asn159Tyr (N159Y).


name: B Acute Lymphoblastic Leukemia with UBTF-ATXN7L3/PAN3, CDX2 ("CDX2/UBTF")

description: B-acute lymphoblastic leukemia associated with concomitant CDX2 deregulation and expression of the chimeric UBTF-ATXN7L3 fusion oncoprotein. It usually affects female adolescents and young adults. The prognosis is poor following treatment with conventional chemotherapy.


name: Extramedullary Disease in Plasma Cell Myeloma

description: Infiltration of organs and soft tissues by malignant (clonal) plasma cells in patients with history of multiple myeloma. Skin, liver, lymph nodes, pleura, and central nervous system are the most frequently affected sites.


Head and Neck Plasmacytoma

description: A plasmacytoma that arises from the head and neck region.


Sinonasal Plasmacytoma

description: A plasmacytoma that arises from the sinonasal tract.


DS Stage IIA Multiple Myeloma

description: Durie/Salmon stage II multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: Progressive Hairy Cell Leukemia Initial Treatment

description: A hairy cell leukemia requiring initial treatment because of the presence of signs of progression.  Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications.  Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.


name: Refractory Transformed Chronic Lymphocytic Leukemia

description: Chronic lymphocytic leukemia which has undergone histologic transformation to an aggressive diffuse large B-cell lymphoma (Richter's transformation) and has become resistant to treatment.


name: B Lymphoblastic Leukemia/Lymphoma with MYC Rearrangement

description: B-lymphoblastic leukemia/lymphoma associated with MYC gene rearrangement. The prognosis is poor.


Primary cutaneous plasmacytoma

description: A plasmacytoma that arises in the skin.


name: B Acute Lymphoblastic Leukemia with PAX5 Alteration

description: B-acute lymphoblastic leukemia associated with PAX5 gene alteration, including rearrangements, point mutations, and intragenic lesions. This is a provisional entity.


name: B Lymphoblastic Leukemia/Lymphoma with TCF3-HLF Rearrangement

description: An exceptionally rare childhood B-lymphoblastic leukemia/lymphoma associated with TCF3-HLF gene rearrangement resulting in the formation of TCF3-HLF chimeric transcription factor. The prognosis is poor.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, JAK-STAT Activated

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with aberrant activation of the JAK-STAT signaling pathway.


name: Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

description: Chronic lymphocytic leukemia characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.


Plasma cell myeloma refractory

description: Multiple myeloma that is resistant to treatment.


Testicular Plasmacytoma

description: A rare plasmacytoma that arises in the testis. At presentation the involvement is usually unilateral.


name: B Acute Lymphoblastic Leukemia with Germline PAX5 Mutation

description: B-acute lymphoblastic leukemia that results from germline mutation of the PAX5 gene.


DS Stage II Plasma Cell Myeloma

description: Multiple myeloma that fits in neither stage I nor stage III.  Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden).  The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL.  Impaired renal function worsens prognosis regardless of stage.  Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months).  (PDQ)


name: B Acute Lymphoblastic Leukemia with MEF2D Rearrangement

description: B-acute lymphoblastic leukemia associated with MEF2D gene rearrangement. The prognosis is poor.


Chronic lymphocytic leukemia refractory

description: Chronic lymphocytic leukemia that is resistant to treatment.


name: Transformed Chronic Lymphocytic Leukemia to Hodgkin Lymphoma

description: Histologic transformation of chronic lymphocytic leukemia to Hodgkin lymphoma.


name: Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

description: The reemergence of B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 after a period of remission.


name: Extramedullary Disease in Multiple Myeloma Involving the Uterine Corpus

description: Infiltration of the uterine corpus by malignant (clonal) plasma cells in patients with history of multiple myeloma.


name: Childhood B Lymphoblastic Leukemia/Lymphoma

description: B lymphoblastic leukemia/lymphoma that occurs during childhood.


Multiple Myeloma with t(11;14)(q13;q32)

description: Multiple myeloma characterized by the presence of t(11;14)(q13;q32). It is the most common immunoglobulin heavy chain translocation found in multiple myeloma and results in CCND1 overexpression.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: B acute lymphoblastic leukemia characterized by a gene-expression profile similar to that of BCR-ABL1-positive B acute lymphoblastic leukemia, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL1 Rearranged

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with ABL1 gene rearrangement.


name: Chronic Lymphocytic Leukemia- Modified Rai Staging System

description: A term that refers to the staging of chronic lymphocytic leukemia according to modified Rai staging system. This system is mainly used in North America.


Chronic lymphocytic leukemia stage 3

description: Risk: High; Findings: Lymphocytosis and hemoglobin less than 11 g/dL; Survival (months): 30. (from AJCC 8th Ed.)


RISS Stage II Multiple Myeloma

description: Not stage I or III. (from AJCC 8th Ed.)


name: Low-Hypodiploid B Acute Lymphoblastic Leukemia

description: B-acute lymphoblastic leukemia associated with a low hypodiploid karyotype.


Multiple Myeloma by ISS Stage

description: A header term that refers to the staging of multiple myeloma according to the International Staging System.


Recurrent Burkitt Leukemia

description: The reemergence of Burkitt leukemia after a period of remission.


name: Plasma Cell Post-Transplant Lymphoproliferative Disorder

description: A plasma cell neoplasm that arises in a patient with a history of organ transplantation.


Multiple Myeloma by RISS Stage

description: A staging system for multiple myeloma based on the Revised International Staging System (RISS) criteria. This staging system does not apply to smoldering multiple myeloma (no AJCC staging system), monoclonal gammopathy of undetermined significance (no AJCC staging system), and Waldenstrom macroglobulinemia (no AJCC staging system). (from AJCC 8th Ed.)


name: B Acute Lymphoblastic Leukemia with Germline Predisposition

description: B-acute lymphoblastic leukemia that results from germline gene mutations. This category includes B-acute lymphoblastic leukemia with germline PAX5 mutation and B-acute lymphoblastic leukemia with germline IKZF1 mutation.


Adult Burkitt Leukemia

description: The leukemic counterpart of Burkitt lymphoma occurring in adults.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


ISS Stage II Plasma Cell Myeloma

description: Multiple myeloma with blood levels of beta-2-microglobulin between 3.5 and 5.5 mg/L.


Recurrent B-Cell Malignant Neoplasm

description: The reemergence of a B-cell malignant neoplasm after a period of remission.


Plasmacytoma anaplastic

description: A plasmacytoma characterized by the presence of malignant plasma cells with anaplastic features.


name: B Acute Lymphoblastic Leukemia with MYC Rearrangement

description: B-acute lymphoblastic leukemia associated with MYC gene rearrangement. The prognosis is poor.


Refractory Burkitt Leukemia

description: Burkitt leukemia resistant to treatment.


name: Multiple Myeloma with NSD2 Translocation

description: Multiple myeloma characterized by the presence of a translocation involving the NSD2 gene.


name: Recurrent Transformed Chronic Lymphocytic Leukemia

description: The reemergence of chronic lymphocytic leukemia transformed to aggressive diffuse large B-cell lymphoma (Richter's transformation) after a period of remission.


name: Extramedullary Disease in Multiple Myeloma Involving the Skin

description: Infiltration of the skin by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Advanced B-Cell Malignant Neoplasm

description: A B-cell malignant neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: B Acute Lymphoblastic Leukemia with ZNF384 Rearrangement

description: B-acute lymphoblastic leukemia associated with ZNF384 gene rearrangement. The prognosis is variable.


name: B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 with Lymphoid Only Involvement

description: B-acute lymphoblastic leukemia associated with t(9;22)(q34.1;q11.2); BCR-ABL1 and characterized by lymphoblastic proliferation without differentiating myeloid cell proliferation.


Stage C Chronic Lymphocytic Leukemia

description: Findings: Lymphocytosis, adenopathy, and enlarged spleen and/or liver; Survival (months): 72. (from AJCC 8th Ed.)


Cutaneous Chronic Lymphocytic Leukemia

description: A chronic lymphocytic leukemia that affects the skin.


DS Stage III Plasma Cell Myeloma

description: Multiple myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ)


DS Stage I Plasma Cell Myeloma

description: Multiple myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)


name: B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: A B-acute lymphoblastic leukemia (B-ALL) that does not have the cytogenetic abnormality t(9;22)(q34;q11.2). Most cases of B-ALL do not have this translocation.


DS Stage IIIA Multiple Myeloma

description: Durie/Salmon stage III multiple myeloma associated with a relatively normal renal function (serum creatinine concentration < 2.0 mg/dL).


name: B Lymphoblastic Leukemia/Lymphoma with ETV6-RUNX1-Like Features

description: B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of ETV6-RUNX1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic ETV6-RUNX1 rearrangement, and rearrangements or deletions of ETV6 and IKZF1 genes.


name: Recurrent B Acute Lymphoblastic Leukemia

description: The reemergence of B acute lymphoblastic leukemia after a period of remission.


RISS Stage III Multiple Myeloma

description: Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.)


name: B Acute Lymphoblastic Leukemia Associated with Down Syndrome

description: A B-acute lymphoblastic leukemia that occurs in patients with Down syndrome. It usually affects young children, but it can occur in adults as well. It has an unfavorable clinical outcome. Cases of T-acute lymphoblastic leukemia in patients with Down syndrome have not been reported.


name: Hyperdiploid B Acute Lymphoblastic Leukemia

description: A B-cell acute leukemia characterized by the presence of lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome.


name: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

description: B-lymphoblastic leukemias/lymphomas characterized by the absence of recurrent genetic abnormalities.


name: B Acute Lymphoblastic Leukemia with NUTM1 Rearrangement

description: B-acute lymphoblastic leukemia associated with NUTM1 gene rearrangement. The prognosis is good.


ISS Stage III Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)


DS Stage IB Multiple Myeloma

description: Durie/Salmon stage I multiple myeloma associated with abnormal renal function (serum creatinine concentration greater than or equal to 2.0 mg/dL).


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, ABL Class Rearranged

description: B-acute lymphoblastic leukemia, BCR-ABL1-like associated with rearrangement of an ABL class gene (e.g., ABL1, ABL2, CSF1R, PDGFRA, and PDGFRB).


name: Recurrent B-Cell Prolymphocytic Leukemia

description: The reemergence of a B-cell prolymphocytic leukemia after a period of remission.


name: Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

description: Histologic transformation of an indolent chronic lymphocytic leukemia to an aggressive diffuse large B-cell lymphoma.


name: Extramedullary Disease in Multiple Myeloma Involving the Kidney

description: Infiltration of the kidney by malignant (clonal) plasma cells in patients with history of multiple myeloma.


Multiple Myeloma with Hyperdiploidy

description: Multiple myeloma characterized by the presence of plasma cells in which the chromosomal number is greater than the normal diploid number.


Chronic lymphocytic leukemia stage 0

description: Risk: Low; Findings: Lymphocytosis only; Survival (months): more than 120. (from AJCC 8th Ed.)


name: Refractory B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

description: B acute lymphoblastic leukemia, Philadelphia chromosome negative, that does not respond to treatment.


name: B Acute Lymphoblastic Leukemia with ZNF362 Rearrangement

description: B-acute lymphoblastic leukemia associated with ZNF362 gene rearrangement. The prognosis is variable.


name: Refractory B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

description: B-acute lymphoblastic leukemia, BCR-ABL1-like that does not respond to treatment.


ISS Stage I Plasma Cell Myeloma

description: Multiple myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)


name: B-lymphoblastic leukemia lymphoma BCR-ABL1-like

description: B lymphoblastic leukemia/lymphoma characterized by a gene-expression profile similar to that of BCR-ABL1-positive B lymphoblastic leukemia/lymphoma, absence of the pathognomonic BCR-ABL1 rearrangement, alterations of lymphoid transcription factor genes, and a poor outcome.


name: B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, Not Otherwise Specified

description: B-acute lymphoblastic leukemia, BCR-ABL1-like in which further genetic/molecular characterization is not available.


Multiple Myeloma Myeloma by DS Stage

description: A header term that refers to the staging of multiple myeloma according to the Durie/Salmon staging system.


Childhood Burkitt Leukemia

description: The leukemic counterpart of Burkitt lymphoma occurring in children.  The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood.  This is an aggressive leukemia.


Nasal Cavity Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that arises from the nasal cavity.


Nasal Cavity Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the nasal cavity.


name: Nasal Cavity Large Cell Neuroendocrine Carcinoma

description: A large cell neuroendocrine carcinoma that arises from the nasal cavity.


name: Nasal Cavity Small Cell Neuroendocrine Carcinoma

description: A small cell neuroendocrine carcinoma that arises from the nasal cavity.


peri-centrosomal recycling endosome

description: A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes.


name: Penile Undifferentiated Pleomorphic Sarcoma

description: A rare undifferentiated pleomorphic sarcoma that occurs in the penis.


Non-Neoplastic Vision Disorder

description: A non-neoplastic disorder that causes a disturbance in normal vision. Representative examples include amblyopia, astigmatism, myopia, and cataracts.


Color Blindness, Inherited

description: Genetic based difficulty in distinguishing colors.


Optical Illusion

description: The visual perception of an image that differs from the reality of the image.


name: Advanced Extracranial Malignant Solid Neoplasm

description: A malignant solid neoplasm that arises from any anatomic site other than the brain and has spread extensively to other anatomic sites or is no longer responding to treatment.


Ciliary Body Adenocarcinoma

description: An adenocarcinoma arising from the pigmented or non-pigmented ciliary epithelium.


Stage IIB Uveal Melanoma AJCC v7

description: Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Stage IIA Uveal Melanoma AJCC v7

description: Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0). T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Choroid Melanoma

description: Choroid melanoma that has spread from its primary site to another anatomic site.


name: Metastatic Malignant Neoplasm in the Uvea

description: A malignant neoplasm that has spread to the uvea from another anatomic site.


Uveal Melanocytoma

description: A subtype of ciliary body, iris, and choroidal nevi. It is intensely pigmented and composed of large, plump, polyhedral cells.


Choroid Spindle Cell Type A Melanoma

description: A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


name: Uveal Melanoma by Gene Expression Profile


name: Locally Advanced Unresectable Uveal Melanoma

description: Uveal melanoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.


Uveal Spindle Cell Type A Melanoma

description: A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage III Uveal Melanoma AJCC v7

description: Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC (T4d-e, N0, M0).  T2c: Ciliary body and choroid: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T2d: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T3b: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement. T3c: Ciliary body and choroid: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. T4a: Iris: Tumor with extrascleral extension less than or equal to 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 without ciliary body involvement and extraocular extension.  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Uveal Class 2 Melanoma

description: Gene expression profiling that classifies uveal melanomas into a high-grade group.


Uveal Class 1a Melanoma

description: Uveal melanoma with low metastatic risk as defined by gene expression profiling.


Ciliary Body Nevus

description: A benign nevus that arises from the ciliary body. Only a small percentage of cases progress to ciliary body melanoma.


Stage IIIC Uveal Melanoma AJCC v7

description: Stage IIIC includes: T4d-e, N0, M0.  T4d: Ciliary body and choroid: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4e: Ciliary body and choroid: Any tumor size category with extraocular extension more than 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Refractory Uveal Melanoma

description: Uveal melanoma that is resistant to treatment.


Choroidal Ganglioneuroma

description: A rare ganglioneuroma that arises from the choroid.


Uveal Melanocytic Neoplasm

description: A melanocytic neoplasm that arises from the iris, ciliary body, and choroid. This category includes nevus and its subtype melanocytoma, and melanoma.


name: Choroidal and Ciliary Body Melanoma by AJCC v8 Stage

description: A term that refers to the staging of choroidal and ciliary body melanoma, following the rules of the TNM AJCC v8 classification system.


Unresectable Uveal Melanoma

description: Uveal melanoma that is not amenable to surgical resection.


name: Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIB includes: (T2b, N0, M0); (T3a, N0, M0).  T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Choroid Spindle Cell Type B Melanoma

description: A choroid melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


name: Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0). T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Uveal Class 1b Melanoma

description: Uveal melanoma with intermediate metastatic risk as defined by gene expression profiling.


name: Ciliary Body Spindle Cell Type B Melanoma

description: A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Stage II Uveal Melanoma AJCC v7

description: Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Iris: Tumor limited to the iris more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 with ciliary body involvement.  T1c: Iris: Tumor limited to the iris with secondary glaucoma.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  T1d: Ciliary body and choroid: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter. T2a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with secondary glaucoma.  Ciliary body and choroid: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Ciliary body and choroid: Tumor size category 2 with ciliary body involvement.  T3a: Iris: Tumor confluent with or extending into the ciliary body, choroid, or both, with sclera extension and secondary glaucoma. Ciliary body and choroid: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage III Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage III includes: IIIA (T2c-d, N0, M0); (T3b-c, N0, M0); (T4a, N0, M0); IIIB (T3d, N0, M0); (T4b-c, N0, M0); IIIC: (T4d-e, N0, M0). T2c: Tumor size category 2 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T2d: Tumor size category 2 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T3b: Tumor size category 3 with ciliary body involvement. T3c: Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4a: Tumor size category 4 without ciliary body involvement and extraocular extension. T3d: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter.  T4b: Tumor size category 4 with ciliary body involvement. T4c: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


Stage I Uveal Melanoma AJCC v7

description: Stage I includes: T1a, N0, M0.  T1a: Iris: Tumor limited to the iris not more than 3 clock hours in size.  Ciliary body and choroid: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIA includes: (T1b-d, N0, M0); (T2a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


name: Stage I Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage I includes: T1a, N0, M0. T1a: Tumor size category 1 without ciliary body involvement and extraocular extension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 8th ed.)


name: Stage IV Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c). N1: Regional lymph node metastasis or discrete tumor deposits in the orbit. M0: No distant metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less. M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm. M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.1 cm or more.  (AJCC 8th ed.)


name: Ciliary Body Spindle Cell Type A Melanoma

description: A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli.


Stage IIIB Uveal Melanoma AJCC v7

description: Stage IIIB includes: (T3d, N0, M0); (T4b-c, N0, M0).  T3d: Ciliary body and choroid: Tumor size category 3 with ciliary body involvement and extraocular extension less than or equal to 5 mm in diameter.  T4b: Iris: Tumor with extrascleral extension more than 5 mm in diameter.  Ciliary body and choroid: Tumor size category 4 with ciliary body involvement.  T4c: Ciliary body and choroid: Tumor size category 4 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Metastatic Uveal Melanoma

description: Uveal melanoma that has spread from its primary site to another anatomic site.


Iris Mixed Cell Melanoma

description: A melanoma arising from the iris. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells.


Stage IV Uveal Melanoma AJCC v7

description: Stage IV includes: (Any T, N1, M0); (Any T, Any N, M1a-c).  N1: Regional lymph node metastasis. M1a: Distant metastasis, with the largest diameter of the largest metastasis measuring 3 cm or less.  M1b: Distant metastasis, with the largest diameter of the largest metastasis measuring 3.1-8.0 cm.  M1c: Distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.  (AJCC 7th ed.)


Benign neoplasm of uveal tract

description: A neoplasm that arises from the uvea and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential..


name: Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage IIIC includes: T4d-e, N0, M0. T4d: Tumor size category 4 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T4e: Any tumor size category with extraocular extension more than 5 mm in largest diameter. N0: No regional lymph node metastasis. M0: No distant metastasis.  (AJCC 8th ed.)


name: Metastatic Malignant Neoplasm in the Iris

description: A malignant neoplasm that has spread to the iris from another anatomic site.


name: Stage II Choroidal and Ciliary Body Melanoma AJCC v8

description: Stage II includes: IIA (T1b-d, N0, M0); (T2a, N0, M0); IIB (T2b, N0, M0); (T3a, N0, M0).  T1b: Tumor size category 1 with ciliary body involvement.  T1c: Tumor size category 1 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in largest diameter.  T1d: Tumor size category 1 with ciliary body involvement and extraocular extension less than or equal to 5 mm in largest diameter. T2a: Tumor size category 2 without ciliary body involvement and extraocular extension. T2b: Tumor size category 2 with ciliary body involvement. T3a: Tumor size category 3 without ciliary body involvement and extraocular extension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 8th ed.)


Uveal Melanoma by AJCC v7 Stage

description: A term that refers to the staging of uveal melanoma, following the rules of the TNM AJCC v7 classification system.


Uveal Spindle Cell Type B Melanoma

description: A uveal melanoma characterized by the presence of malignant spindle-shaped melanocytes with larger nuclei and distinct nucleoli.


Uveal Class 1 Melanoma

description: Gene expression profiling that classifies uveal melanomas into a low-grade group.


Uveal Nevus

description: A benign nevus derived from melanocytes of the uveal tract. Only a small percentage of cases progress to uveal melanoma.


Advanced Uveal Melanoma

description: Uveal melanoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Iridociliary Melanoma

description: Melanoma that affects both the iris and ciliary body.


Iris Epithelioid Cell Melanoma

description: An iris melanoma characterized by the presence of malignant large epithelioid melanocytes.


name: Metastatic malignant neoplasm to ciliary body

description: A malignant neoplasm that has spread to the ciliary body from another anatomic site.


Conjunctival keratoacanthomas

description: A rapidly growing neoplasm that arises from the conjunctiva. It is characterized by a proliferation of squamous cells, acanthosis, keratinization, dysplasia, increased mitotic activity, and a central crater filled with keratinocytes. It is considered a variant of well-differentiated squamous cell carcinoma with distinct clinical behavior.


Conjunctival Spindle Cell Carcinoma

description: A variant of conjunctival squamous cell carcinoma characterized by the presence of malignant spindle cells and/or pleomorphic cells.


Stage II Fallopian Tube Cancer AJCC v8

description: Stage II includes: T2, N0, M0. T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIA Fallopian Tube Cancer AJCC v8

description: Stage IIA includes: T2a, N0, M0. T2a: Fallopian tube cancer with extension and/or implants on the uterus and/or fallopian tube(s) and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IIB Fallopian Tube Cancer AJCC v8

description: Stage IIB includes: T2b, N0, M0. T2b: Fallopian tube cancer with tumor extension to and/or implants on other pelvic tissues. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Laryngeal Paraganglioma

description: An extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to the larynx.  Patients may present with hoarseness and dysphagia.


Finding by Site or System

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A term that refers to the classification of a clinical or laboratory finding according to the anatomic site or system that is involved.


Muscle Weakness Right-Sided

description: A reduction in the strength of the muscles in the right side of the body.


Congenital urinary tract obstruction

description: An impediment to the flow of urine along the urinary tract, which is present at birth.


Atrial Couplet by ECG Finding

description: An electrocardiographic finding in which two premature atrial complexes occur sequentially. (CDISC)


name: Right Bundle Branch Block by ECG Finding

description: An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration greater than or equal to 120 ms.  An RsR' complex is typically present in leads V1 and V2. (CDISC)


name: AV Block Second Degree Mobitz Type II by ECG Finding


Jejunal Obstruction

description: Blockage of the normal flow of the small intestinal contents in the jejunum.


Todd's Paralysis

description: A neurological condition experienced by individuals with epilepsy, in which a seizure is followed by a brief period of temporary paralysis.


Fallopian tube obstruction

description: Blockage of the normal flow of the contents in the fallopian tube.


Gastrointestinal stenosis

description: A narrowing or stricture within the digestive system.


Carpal Spasm

description: A spasmodic contraction of the muscles of the hands, especially the wrists, such as during alkalosis or tetany. (ACC/AHA)


New daily persistent headache

description: A bilateral, unremitting headache of mild to moderate intensity that occurs daily and may be associated with photophobia, phonophobia, or mild nausea.


Perforation of bladder

description: A rupture in the bladder wall due to traumatic or pathologic processes.


Pregnancy Finding

description: Symptoms, signs, diagnostic examinations or a test results in a pregnant mother.


AV Block Third Degree by ECG Finding

description: An electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC)


Hypotonic-hyporesponsive episode

description: Acute onset of unresponsiveness or diminished level of consciousness, associated with loss of muscle tone and pallor or cyanosis, that occurs within 48 hours after childhood immunizations. It is primarily associated with pertussis-containing vaccines administered to children under two years of age.


Subclavian vein stenosis

description: Narrowing of the lumen of the subclavian vein.


Obstruction of trachea

description: Blockage of the lumen of the trachea. Causes include secretions, foreign bodies, and tumors.


Damage of Vaginal Mucosa

description: Injury to vaginal mucosa.


Caries into Dentin

description: Tooth decay that extends through the enamel into the dentin layer.


Intrapartum Shock

description: Severe loss of blood pressure leading to inadequate tissue perfusion after the onset of labor but prior to the delivery of the fetus.


Neurogenic shock (disorder)

description: Shock resulting from neurogenic vasodilation, which can be produced by cerebral trauma or hemorrhage, spinal cord injury, deep general or spinal anesthesia, or toxic central nervous system depression.


name: Brachial plexus palsy due to birth trauma

description: Birth injury to the brachial plexus. It results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm, usually in the first week of life. In the majority of cases there is spontaneous recovery.


Pedal Spasm

description: A spasmodic contraction of the muscles of the feet, especially the ankles, such as during alkalosis or tetany. (ACC/AHA)


Syncope due to Acquired Heart Lesion

description: A condition in which syncope occurs due to a disease process of the heart with which the patient was not born. (ACC/AHA)


Superficial injury of cornea

description: Trauma to the corneal epithelium.


Palsy

description: Muscle weakness or paralysis of neurologic origin.


Cardiac septal defect residual shunt

description: Irregular blood flow in the heart after surgical correction of a septal defect.


Shock, Traumatic

description: Any shock produced by trauma.


Psychogenic tremor

description: An involuntary, compulsive, repetitive stereotyped movement.


R Wave Abnormality by ECG Finding

description: An electrocardiographic finding of an atypical R wave within the QRS complex; it is due to a disturbance in the depolarization mechanism of the ventricular myocardium.


Infertility Related to Treatment

description: Infertility that is associated with a treatment.


Cardiogenic Shock Related to COVID-19

description: Cardiogenic shock in a patient with probable or confirmed acute COVID-19.


Normal Virilization

description: The normal development of male secondary sexual characteristics (such as hirsutism, deepening of the voice) in pubertal boys due to testosterone effects.


Dactylitis

description: Inflammation of the fingers or toes. This may be accompanied by pain and discoloration.


Insulin Coma

description: A hypoglycemia-induced comatose state resulting from a large dose of exogenous insulin.


Dissecting aortic aneurysm

description: A dissecting aneurysm formed between the intimal and medial layers of the aortic wall due to a tear in the tunica intima.


Venous Injury

description: Damage to a vein from traumatic or pathologic processes.


Persistent Atrial Flutter

description: An electrocardiographic finding of atrial flutter which is present during the entire recording.


Large Pleural Effusion

description: A pleural effusion that is typically characterized as more than one liter.


Pregnancy Outcome

description: Findings observed at the end of a pregnancy.


name: Maximum ST Segment Depression by ECG Finding

description: An electrocardiographic finding of the maximum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Hypotension due to Cardiac Dysfunction

description: A condition in which there is hypotension because of inadequate pumping function of the heart. (ACC/AHA)


Cerebral cyst

description: A fluid filled sac within the cerebrum. It is can be congenital, trauma related or secondary to another medical condition for example an infarction.


Intestinal Stoma Obstruction

description: A blockage of the intestinal stoma.


Injury of gastrointestinal tract

description: Trauma to the gastrointestinal tract or accessory organs of digestions.


Cyst of thyroid

description: Abnormal fluid filled sac within the thyroid gland.


Secondary pulmonary hypertension

description: Pulmonary hypertension that is caused by an underlying condition.


Reproductive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the reproductive system.


Vaginal Perforation

description: A rupture in the vaginal wall due to traumatic or pathologic processes.


Intraoperative Arterial Injury

description: Damage to an artery during a surgical procedure.


Pregnancy Status

description: The pregnancy status of an individual.


name: High Grade Atrioventricular Block by ECG Finding

description: An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by two or more consecutive non-conducted P waves. (CDISC)


Ureter Compression

description: Narrowing of the luminal diameter of one or both ureters due to extrinsic pressure.


COVID-19-Associated Acute Liver Injury

description: Acute liver injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Foreign body in esophagus

description: Extraneous material located within the esophagus.


name: Immunodeficiency due to Functional Defects

description: An indication that an immunodeficiency disorder is caused by the presence of immune cells that are dysfunctional.


Moderate Hepatic Insufficiency

description: Findings indicating moderate impairment of liver function.


name: Chronic Maternal Hypertension with Superimposed Preeclampsia

description: Chronic hypertension in association with preeclampsia.


Reproductive System Hemorrhage

description: Bleeding originating in the organs and tissue that aid in reproduction.


Cardiovascular injury

description: Trauma to the heart and/or blood vessels.


Urostomy Obstruction

description: Blockage of the urostomy.


Esophageal injury

description: Trauma to the esophagus.


Extreme Preterm Birth

description: Birth when a fetus is less than 28 weeks gestational age.


Sinus Bradycardia by ECG Finding

description: An electrocardiographic finding of abnormally slow heart rate with its origin in the sinus node. Thresholds for different age, gender, and patient populations exist. (CDISC)


Female Virilization

description: The development of male secondary sexual characteristics (such as hirsutism, deepening of the voice, or clitoral enlargement) in girls or adult females.


Vaginal obstruction

description: Congenital or acquired blockage of the vagina.


Anterior segment ischemia

description: Compromise of blood supply to the anterior segment of the eye.


Burn of esophagus

description: Thermal or caustic injury to the esophagus.


Spinal Meningeal Cyst

description: A cerebrospinal fluid-filled pouch or sac-like protrusion of the arachnoid, dura mater, or nerve root sheath which may contain neural tissue.


Eye and Ear Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the organs of special sense.


Intrapartum Stillbirth

description: Fetal death greater than or equal to 20 weeks of gestation during labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.


Visual Halo

description: Hazy ring around bright lights seen by some patients with refractive error or optical defects, e.g. cataracts, or corneal swelling.


Injury of conjunctiva

description: Trauma to the conjunctiva of the eye.


Elective Abortion Finding

description: An abortion performed due to individual choice, in the absence of a harmful medical condition caused by pregnancy.


Leg Injuries

description: Trauma to the lower extremity, which is confined to the area between the hip and ankle joints.


Craniotabes

description: Softening of the skull seen in newborns due to incomplete mineralization.


Injury of colon

description: Trauma to the colon.


Fetal Heart Finding

description: An observation of the fetal heart that may or may not be abnormal.


Urethral cyst

description: A cystic lesion located in the urethra.


Pulmonary vein obstruction

description: Blockage of the lumen of the pulmonary vein.


Testosterone Excess

description: Abnormally high level of testosterone.


Ureteric Perforation

description: A rupture in the wall of the ureter due to traumatic or pathologic processes.


name: Minimum ST Segment Depression by ECG Finding

description: An electrocardiographic finding of the minimum depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Urinary System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the urinary system.


Reperfusion Injury

description: Tissue damage caused when blood supply returns to tissue after a period of ischemia or lack of oxygen. The restoration of circulation results in inflammation and oxidative damage.


name: Cardiogenic Shock Stage D Related to COVID-19

description: Clinical signs of deteriorating cardiogenic shock in a patient with probable or confirmed acute COVID-19. Failure to respond to initial interventions to restore adequate perfusion after 30 minutes. Further more intensive therapies are required, including the addition of mechanical circulatory support.


Undesired Nerve Stimulation

description: Unintended reaction in nervous system caused by electrical stimulation.


Carotenosis Cutis

description: Orange or yellow discoloration of the skin caused by excessive deposits of carotene.


Anticipatory Vomiting

description: A situation in which an individual vomits prior to a medical treatment, commonly chemotherapy, as part of a conditioned/learned response after having previously experienced nausea and/or vomiting as a direct result of that same (or a similar) treatment.


name: COVID-19-Associated Acute Gastrointestinal Tract Injury

description: Acute gastrointestinal tract injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Enhanced Tendon Reflex

description: Greater than normal deep tendon reflexes.


Visceral Artery Ischemia

description: Decreased blood supply to the small or large intestine due to narrowing or blockage of a visceral (mesenteric) artery. The ischemia results to the damage of the intestinal tissues. It may be chronic, caused by atherosclerosis or acute, secondary to the formation of a thrombus or embolus in the mesenteric arterial lumen. In chronic ischemia, patients present with abdominal pain manifested in a short time after a meal and weight loss. In acute ischemia, patients present with sudden and acute abdominal pain, nausea and vomiting, and blood in the stool.


Caries Restricted to Enamel

description: Tooth decay that is restricted to the enamel layer.


Adrenal Cyst

description: A cyst located in the adrenal gland.


Duodenal hemorrhage

description: Bleeding originating from the duodenum.


Congenital Neurogenic Bladder

description: Neurogenic bladder, the cause of which is present at birth.


AV Block Second Degree by ECG Finding

description: An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles. This is manifest on the ECG by regular P waves which intermittently are not followed by QRS complexes. (CDISC)


Borderline hypertension

description: Blood pressure in the zone between the highest normal level and the level that is considered hypertensive.


Jacksonian Seizure

description: A partial motor seizure that begins in a single area of the body and progresses to include other areas on the same side of the body.


Oculocardiac Reflex

description: Slowing or cessation of the heart rate secondary to traction on the extraocular muscle.


Intraoperative cardiac valve injury

description: An intraoperative event that causes abnormal valve function; this is usually a tear in the leaflet or the chordae tendinae.


Rheumatic tricuspid valve stenosis

description: Tricuspid valve stenosis secondary to rheumatic fever.


name: Cardiogenic Shock with Distributive Shock Related to COVID-19


name: Intervertebral Disc Compression or Protrusion

description: Degenerative, pathological or traumatic changes in the cartilaginous tissue of the spine leading to unwanted compression or protrusion of the disc.


Ectopic Atrial Rhythm by ECG Finding

description: An electrocardiographic finding of a regular atrial rhythm with atrial rate of less than 101 beats per minute which does not originate in the sinus node, and which is characterized by P waves whose morphology differs from the P wave morphology during sinus rhythm. (CDISC)


Ventricular Arrhythmia by ECG Finding

description: An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles.


Ear Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the ear.


name: Coronary Artery Aneurysm Related to COVID-19

description: Coronary artery aneurysm in a patient with probable or confirmed acute COVID-19.


Alterations in Smell or Taste

description: A change to taste and/or olfactory perception resulting from disease processes or treatment.


Non-Febrile Seizure

description: A seizure that is not associated with fever.


Jugular vein injury

description: Damage to the jugular vein from traumatic or pathologic processes.


name: Psychosexual dysfunction with inhibited sexual excitement

description: Recurrent and persistent suppression of sexual excitement during sexual activity.


Decreased Physical Activity

description: A reduction in the normal physical activity for an individual.


Cecal Hemorrhage

description: Bleeding originating in the cecum.


name: Mean ST Segment Depression by ECG Finding

description: An electrocardiographic finding of the average depression of the ST segment, obtained from a set of measurements of the depression of the ST segment.


Arrhythmogenic Syncope

description: A condition in which syncope occurs due to an arrhythmia. (ACC/AHA)


Intraoperative Ear Injury

description: Damage to the ear during a surgical procedure.


Arterial Injury

description: Damage to an artery from traumatic or pathologic processes.


Endocrine System Signs and Symptoms

description: Patient complaints, physical findings, laboratory findings referable to the endocrinologic system.


Therapeutic Abortion Finding

description: An abortion performed on the individual due to a harmful medical condition caused by pregnancy.


Drug-induced hypotension

description: A condition in which there is hypotension because of the effects of a medication or other substance. (ACC/AHA)


Micropsia

description: An alteration in visual perception that causes objects to appear smaller than their actual size.


Hormone Imbalance

description: An abnormal finding indicating that the level of a particular hormone is not within the expected normal values.


Syncope due to Congenital Heart Lesion

description: A condition in which syncope occurs due to a disease process of the heart with which the patient was born. (ACC/AHA)


Rheumatic mitral stenosis

description: Mitral valve stenosis secondary to rheumatic fever.


name: Headache due to external compression of head

description: Headache resulting from pressure applied to the cutaneous nerves of the head.


Acoustic Trauma

description: Injury to the hearing mechanisms within the inner ear, caused by excessively loud noise.


Cyst of pharynx

description: A cervical cyst that occurs as a result of the persistence of one or more of the pharyngeal grooves.


Intraoperative Renal Injury

description: Damage to the kidney during a surgical procedure.


Perforation of great vessels

description: Damage to the venae cavae, pulmonary artery, pulmonary veins or aorta resulting from a full thickness disruption in the integrity of the vessel wall.


Blocked premature atrial contraction

description: An electrocardiographic finding of premature atrial complexes which are not conducted to the ventricle, and which are not followed by a QRS complex. (CDISC)


Aneurysm, Ruptured

description: An aneurysm that has burst, resulting in hemorrhage into adjacent tissues.


Malignant Bowel Obstruction

description: Obstruction of the bowel by an advanced malignant tumor. It is a complication especially in patients with an advanced abdominal malignant tumor.


Ileal hemorrhage

description: Bleeding originating from the ileal wall.


Paroxysmal atrial flutter

description: An electrocardiographic finding of atrial flutter which occurs intermittently during the recording. Other rhythms which may be present are sinus rhythm, junctional rhythm, or an atrial paced rhythm.


Atrial bigeminy

description: An electrocardiographic finding of a sinus beat followed by a premature atrial complexes for three or more consecutive cycles; a regularly irregular rhythm of normal and abnormal P waves in a 1-1 ratio. (CDISC)


Intraoperative Cardiac Injury

description: Damage to the heart during a surgical procedure.


name: Incomplete Bundle Branch Block by ECG Finding

description: An electrocardiographic finding of partially blocked cardiac electrical impulse conduction along the fibers of one or both bundle branches.


Paronychial Inflammation

description: Swelling and redness of the nail folds.


Umbilical Cord Finding

description: Clinical and laboratory findings about the umbilical cord.


First Trimester Antepartum Hemorrhage

description: Excessive blood loss within the first trimester but prior to onset of labor.


name: Injury of liver with open wound into abdominal cavity

description: Trauma to the liver associated with a break in the tissue that extends into the abdominal cavity.


Aneurysm, Bacterial

description: An aneurysm caused by an infection.


Endometrioma

description: A cystic form of endometriosis affecting the ovary.  It may or may not be associated with endometriosis in other areas in the pelvis.


Marked Sinus Bradycardia by ECG Finding

description: An electrocardiographic tracing demonstrating sinus bradycardia, with a heart rate lower than an acceptable, predetermined threshold.  Different thresholds, for rate and/or duration, may apply to different patient populations.


Lamellar laceration of the globe

description: Traumatic injury to the globe, resulting in a partial thickness wound of the eyewall (cornea and/or sclera). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


name: Acute Liver Injury with Fulminant Failure Related to COVID-19

description: Acute liver injury manifested by rapid loss of liver function associated with abnormal liver enzyme levels, coagulopathy or encephalopathy, and often multiorgan failure in a patient with probable or confirmed acute COVID-19.


Cerebrospinal Fluid Otorrhea

description: Discharge of cerebrospinal fluid through the ear structures.


In-Hospital Cardiac Arrest

description: Cardiac arrest which occurs in the hospital setting.


Knee Injuries

description: Trauma to the knee.


Malignant Effusion

description: An accumulation of fluid that contains floating individual or groups of malignant cells in a body cavity. It results from either the development of a primary malignant neoplasm in the lining of the cavity or spread of a malignant neoplasm in the cavity from another site.


Elbow Injuries

description: Trauma to the elbow joint.


Atrial trigeminy

description: An electrocardiographic finding of two sinus beats followed by a premature atrial complex for 3 or more consecutive cycles; a regularly irregular rhythm of normal and abnormal P waves in a 2-1 ratio. (CDISC)


Congenital stenosis of pulmonary valve

description: Pulmonary valve stenosis that is present at birth.


Intracranial Colloid Cyst

description: Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection.


name: Atrioventricular Nodal Reentry Tachycardia by ECG Finding

description: An electrocardiographic finding of a regular supraventricular tachycardia due to reentry within the AV node. It is characterized by P waves which typically occur nearly simultaneously with the QRS complex, resulting in a P wave which is obscured by the QRS, merged with the QRS or which may follow the QRS. (CDISC)


Acquired Neurogenic Bladder

description: Neurogenic bladder, the cause of which is not present at birth.


Migraine-triggered seizure

description: A seizure triggered by a migraine.


Musculoskeletal Finding

description: Symptoms, physical examination results, and/or laboratory rest results related to the muscles and bones.


Kidney perforation

description: A rupture in the kidney due to traumatic or pathologic processes.


Decreased Uncorrected Visual Acuity

description: Diminished clarity of vision without optical correction (glasses and/or contacts).


name: Cardiac Arrest/Arrhythmia Etiology Unknown

description: An episode of cardiac arrest or arrhythmia where the etiology was unknown. (ACC)


Acquired Urinary Tract Obstruction

description: A urinary tract obstruction, the cause of which is not present at birth.


Adrenal Androgen Excess

description: Excessive secretion of the androgen hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Clinical manifestations may include virilization.


name: Cardiogenic Shock Stage E Related to COVID-19

description: Clinical signs of extremis in a patient with cardiogenic shock and probable or confirmed acute COVID-19. Highly unstable, often with circulatory collapse and/or refractory cardiac arrest with ongoing cardiopulmonary resuscitation (CPR). They are being supported by multiple simultaneous acute interventions including extracorporeal membrane oxygenation (ECMO)-facilitated CPR (eCPR).


name: Complicated Parapneumonic Pleural Effusion

description: An accumulation of fluid in the pleural space adjacent to an infectious pulmonary process, such as a pneumonia or a lung abscess, and that requires therapeutic drainage.


Mitral perforation

description: A rupture in the mitral valve tissue due to traumatic or pathologic processes.