CTP synthase activity

description: Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.


arteriosclerotic retinopathy

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A arteriosclerosis disorder that involves the retina.


pre-B cell allelic exclusion

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Expression of a single heavy chain allele during pre-B cell differentiation.


Palmar erythema

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: positive regulation of peptidyl-serine dephosphorylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation.


name: regulation of acetyl-CoA biosynthetic process from pyruvate

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.


ventricular septal defect

description: The presence of a defect (opening) in the septum that separates the two ventricles of the heart. It can be congenital or acquired.


trigeminal sensory nucleus development

description: The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure.


name: regulation of immature T cell proliferation

description: Any process that modulates the frequency, rate or extent of immature T cell proliferation.


GABA receptor activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.


regulation of type IV hypersensitivity

description: Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.


name: regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

description: Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis.


name: regulation of transcription of nucleolar large rRNA by RNA polymerase I

description: Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I.


azole transmembrane transport

description: The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane.


name: negative regulation by host of viral exo-alpha-sialidase activity

description: The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein.


description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R.


regulation of aldosterone secretion

description: Any process that modulates the frequency, rate or extent of aldosterone secretion.


galactose metabolic process

description: The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.


telomeric loop formation

description: The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region.


name: regulation of transmission of nerve impulse

description: Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.


name: negative regulation of mesenchymal cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.


serotonin secretion by platelet

description: The regulated release of serotonin by a platelet or group of platelets.


name: positive regulation of cellular response to insulin stimulus

description: Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.


Systolic Hypertension

description: Abnormally high systolic blood pressure.


SREBP signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.


regulation of exit from mitosis

description: Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.


Tooth Discoloration

description: A change in tooth color. Causes may be local or systemic and include tobacco use, foods, dental plaques, caries, restorative filling materials, trauma, medications, infections, hereditary diseases, and nutritional deficiencies.


name: negative regulation of cytokine production involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.


Brain Diseases, Metabolic

description: A group of neurologic disorders caused by alterations to the biochemical functioning of the brain. They are characterized by an altered level of consciousness and depressed cerebral functioning.


Cognitive impairment

description: Abnormal cognition is characterized by deficits in thinking, reasoning, or remembering.


name: negative regulation of very-low-density lipoprotein particle remodeling

description: Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.


commissural neuron axon guidance

description: The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.


name: brain-derived neurotrophic factor binding

description: Binding to brain-derived neurotrophic factor.


actin crosslink formation

description: The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.


late endosome lumen

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The volume enclosed by the membrane of a late endosome.


microtubule plus-end binding

description: Binding to the plus end of a microtubule.


cytoplasmic translational initiation

description: The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.


C4-dicarboxylate transport

description: The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.


name: positive regulation of epidermal cell differentiation

description: Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.


name: regulation of branching involved in salivary gland morphogenesis

description: Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium.


regulation of exocyst localization

description: Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


regulation of cellular extravasation

description: Any process that modulates the frequency, rate, or extent of cellular extravasation.


aortic valve morphogenesis

description: The process in which the structure of the aortic valve is generated and organized.


flavonol 3-sulfotransferase activity

description: Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate.


name: negative regulation of triglyceride biosynthetic process

description: Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.


regulation of cilium movement

description: Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.


name: positive regulation of lymphocyte apoptotic process

description: Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.


name: epithelial cell proliferation involved in liver morphogenesis

description: The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver.


sequestering of neurotransmitter

description: The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system.


stress granule assembly

description: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.


fovea centralis

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A depression in the inner retinal surface within the macula lutea, the photoreceptor layer of which is entirely cones and which is specialized for maximum visual acuity.


regulation of isomerase activity

description: Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.


maternal behavior

description: Female behaviors associated with the care and rearing of offspring.


name: regulation of glucuronosyltransferase activity

description: Any process that modulates the frequency, rate or extent of glucuronosyltransferase activity.


intraciliary transport particle A

description: The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.


name: extrinsic component of endoplasmic reticulum membrane

description: The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


establishment of T cell polarity

description: The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.


name: regulation of macrophage differentiation

description: Any process that modulates the frequency, rate or extent of macrophage differentiation.


name: heparan sulfate proteoglycan catabolic process

description: The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.


skeletal muscle atrophy

description: A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.


central nervous system vasculogenesis

description: The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.


aspartate metabolic process

description: The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.


name: metanephric glomerulus vasculature development

description: The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.


RISC-loading complex

description: A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.


cycloplegia

description: Cycloplegia is paralysis of the ciliary muscle of the eye, resulting in a loss of accommodation.


IgE responsiveness, atopic

description: Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.


DNA secondary structure binding

description: Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction.


thyroiditis

description: Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis.


pathologic fistula

description: Abnormal epithelial-lined communication between two anatomical structures.


name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen.


beta-catenin-TCF complex

description: A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.


name: ubiquitin-dependent protein catabolic process via the N-end rule pathway

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.


cholestenol delta-isomerase activity

description: Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol.


tryptophan catabolic process

description: The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


name: medium-chain fatty acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


growth hormone secretion

description: The regulated release of growth hormone from secretory granules into the blood.


Nerve palsy

description: Paralysis that is caused by damage to a nerve.


vitamin D 24-hydroxylase activity

description: Catalysis of the hydroxylation of C-24 of any form of vitamin D.


heat acclimation

description: Any process that increases heat tolerance of an organism in response to high temperatures.


name: negative regulation of cholangiocyte apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process.


name: positive regulation of steroid biosynthetic process

description: Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.


eukaryotic 48S preinitiation complex

description: The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC.


name: positive regulation of mesonephros development

description: Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


excitatory synapse assembly

description: The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse.


description: Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001)


name: regulation of apoptotic DNA fragmentation

description: Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation.


name: proteasome regulatory particle, base subcomplex

description: The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.


acylphosphatase activity

description: Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.


peritonsillar abscess

description: An abscess that develops in the space surrounding one or both palatine tonsils.


endocytic recycling

description: The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.


cytosolic ribosome assembly

description: The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol.


description: A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.


common fibular nerve

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A nerve arising at the terminal division of the sciatic nerve at the popliteal fossa and extending to the neck of the fibula, ultimately innervating the Peroneus muscle[MP].


odontoblast differentiation

description: The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin.


name: regulation of lens fiber cell differentiation

description: Any process that modulates the frequency, rate or extent of lens fiber cell differentiation.


name: long-chain fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


Uterine rupture

description: The complete, nonsurgical disruption of all layers of the uterus.


renal papilla

description: Tip of renal pyramid projecting into a minor calyx.


neuron fate determination

description: The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed.


intestinal disorder

description: A non-neoplastic or neoplastic disorder that affects the small or large intestine.


disorder of pilosebaceous unit

description: A disease that involves the pilosebaceous unit.


description: Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.


name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex

description: A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.


name: regulation of stem cell population maintenance

description: Any process that modulates the frequency, rate or extent of stem cell population maintenance.


protein-glutamic acid ligase activity

description: Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein.


name: positive regulation of antigen processing and presentation of peptide antigen

description: Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen.


DNA strand invasion

description: The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


opsonization

description: The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.


natural killer cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.


regulation of spindle checkpoint

description: Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.


tetrahydrobiopterin binding

description: Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions.


name: positive regulation of ATP biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.


diterpenoid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units.


Perceptual disturbance

description: A misperception of sensory stimuli.


description: Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase.


polycystic kidney disease

description: A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.


name: regulation of CD4-positive, alpha-beta T cell proliferation

description: Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.


name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.


platelet dense granule membrane

description: The lipid bilayer surrounding the platelet dense granule.


postmenopausal atrophic vaginitis

description: Inflammation of the vagina due to thinning of the vaginal wall and decreased lubrication associated with reduced estrogen levels at menopause.


connexin complex

description: An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.


nucleoside salvage

description: Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis.


name: very long-chain fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


name: clathrin-sculpted gamma-aminobutyric acid transport vesicle

description: A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle.


name: negative regulation of trophoblast cell migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.


receptor localization to synapse

description: Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


proteasome assembly

description: The aggregation, arrangement and bonding together of a mature, active proteasome complex.


name: positive regulation of lipoprotein metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


name: regulation of granulocyte macrophage colony-stimulating factor production

description: Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


name: branching involved in labyrinthine layer morphogenesis

description: The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.


name: adenosine 3',5'-bisphosphate transmembrane transport

description: The process in which adenosine 3',5'-bisphosphate is transported across a membrane.


norepinephrine transport

description: The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.


name: negative regulation of smooth muscle cell migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.


name: regulation of natural killer cell chemotaxis

description: Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis.


name: regulation of cytoplasmic pattern recognition receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway.


xenobiotic transport

description: The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


hemolytic-uremic syndrome

description: Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia.


regulation of germinal center formation

description: Any process that modulates the frequency, rate, or extent of germinal center formation.


Decreased Drug Level

description: A reduction in the expected therapeutic effect of a drug due to increased clearance.


name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

description: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.


name: ATP-dependent diacylglycerol kinase activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.


description: Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.


name: desensitization of G protein-coupled receptor signaling pathway

description: The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.


bradykinin receptor binding

description: Binding to a bradykinin receptor.


name: regulation of retina development in camera-type eye

description: Any process that modulates the frequency, rate or extent of retina development in camera-type eye.


name: positive regulation of spindle checkpoint

description: Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.


ESCRT II complex

description: An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.


muscle myosin complex

description: A filament of myosin found in a muscle cell of any type.


response to L-leucine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus.


name: regulation of binding of sperm to zona pellucida

description: Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida.


mannoprotein biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a mannoprotein, a protein that contains covalently bound mannose residues.


lens fiber cell apoptotic process

description: Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


peptidoglycan immune receptor activity

description: Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response.


name: ureter smooth muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter.


Pill-rolling tremor

description: A type of resting tremor characterized by simultaneous rubbing movements of thumb and index fingers against each other.


name: hydroxymethyl-, formyl- and related transferase activity

description: Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor).


Thromboembolic stroke

description: A cerebrovascular accident (stroke) that occurs because of thromboembolism.


gamma-aminobutyric acid transport

description: The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


action potential propagation

description: The propagation of an action potential along the plane of an excitable membrane. Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold.


Chemical conjunctivitis

description: Inflammation of the conjunctiva in a newborn due to chemical irritation which was acquired postnatally from iatrogenic causes.


cranial suture morphogenesis

description: The process in which any suture between cranial bones is generated and organized.


negative regulation of urine volume

description: Any process that decreases the amount of urine excreted from the body over a unit of time.


cinalukast

2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in the human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma.


L-alanine metabolic process

description: The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.


chitin binding

description: Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


name: calcium-dependent protein kinase activity

description: Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP.


name: cellular response to insulin-like growth factor stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.


name: eukaryotic translation initiation factor 2 complex

description: Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.


name: positive regulation of humoral immune response

description: Any process that activates or increases the frequency, rate, or extent of a humoral immune response.


name: positive regulation of calcium ion-dependent exocytosis

description: Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.


name: negative regulation of humoral immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.


name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).


T-tubule organization

description: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


name: negative regulation of telomere maintenance via semi-conservative replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA.


smooth muscle cell proliferation

description: The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.


Hemorrhagic complication of pregnancy

description: Bleeding occurring during pregnancy.


interleukin-20 binding

description: Binding to interleukin-20.


artemether

An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.


Hyposmia

description: A decreased sensitivity to odorants (that is, a decreased ability to perceive odors).


Joint Range of Motion Decreased

description: Decreased joint flexibility.


microtubule nucleation

description: The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).


name: regulation of antibacterial peptide production

description: Any process that modulates the frequency, rate, or extent of antibacterial peptide production.


RNA 5'-end processing

description: Any process involved in forming the mature 5' end of an RNA molecule.


MHC protein complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.


cervical vertebra

description: A vertebra that is located in the cervical region of the vertebral column.


pericardium morphogenesis

description: The process in which the anatomical structure of the pericardium is generated and organized.


renal artery

description: One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates.


name: positive regulation of voltage-gated chloride channel activity

description: Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity.


Abnormality of skin pigmentation

description: An abnormality of the pigmentation of the skin.


maintenance of organelle location

description: Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere.


proline biosynthetic process

description: The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.


name: negative regulation of respiratory burst involved in inflammatory response

description: Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


chondroitin sulfate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


name: single-stranded DNA endodeoxyribonuclease activity

description: Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.


subclavian vein

description: The subclavian vein is a paired large vein, one on either side of the body. Their diameter is approximately that of the smallest finger.


name: positive regulation of receptor catabolic process

description: Any process that activates or increases the frequency, rate or extent of receptor catabolic process.


ovarian hyperstimulation syndrome

description: A complication of ovulation induction in infertility treatment. It is graded by the severity of symptoms which include ovary enlargement, multiple ovarian follicles; ovarian cysts; ascites; and generalized edema. The full-blown syndrome may lead to renal failure, respiratory distress, and even death. Increased capillary permeability is caused by the vasoactive substances, such as vascular endothelial growth factors, secreted by the overly-stimulated ovaries.


name: positive regulation of glomerular mesangial cell proliferation

description: Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation.


putrescine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine.


skin squamous cell carcinoma

description: A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated.


purine metabolism disease

description: A disease that has its basis in the disruption of purine nucleobase metabolic process.


name: negative regulation of establishment of blood-brain barrier

description: Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.


iris morphogenesis

description: The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.


name: negative regulation of Schwann cell proliferation

description: Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


peptidyl-glutamine methylation

description: The addition of a methyl group to a glutamine residue in a protein.


Sickle Cell Dactylitis

description: A severe acute inflammatory response affecting the hands and feet of individuals with with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and finally infarction of the distal portions of the extremities. Clinical signs of pain, swelling and tenderness of digits usually begin in early childhood and may be the initial manifestations of sickle cell anemia. Clinical course is self-limited with instances typically lasting a few weeks and occurring during sickling crises. An initial episode before the age of 1 strongly correlates with a more severe disease course.


regulation of heat generation

description: Any process that modulates the rate or extent of heat generation.


name: columnar/cuboidal epithelial cell development

description: The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.


T cell cytokine production

description: Any process that contributes to cytokine production by a T cell.


direct ossification

description: The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.


name: insulin-like growth factor receptor binding

description: Binding to an insulin-like growth factor receptor.


name: protein transmembrane transporter activity

description: Enables the transfer of a protein from one side of a membrane to the other.


name: regulation of inner ear auditory receptor cell differentiation

description: Any process that modulates the frequency, rate or extent of auditory hair cell differentiation.


retinal metabolic process

description: The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.


name: midbrain dopaminergic neuron differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron.


negative regulation of sterol transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of androgen secretion

description: Any process that modulates the frequency, rate or extent of androgen secretion.


telomere cap complex

description: A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.


nicotinamide metabolic process

description: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms.


alkali metal ion binding

description: Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen.


name: regulation of intracellular lipid transport

description: Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.


C-X-C chemokine binding

description: Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.


angiotensin-activated signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: purine nucleoside monophosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.


heme transport

description: The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


B-1a B cell differentiation

description: The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.


positive regulation of cytolysis

description: Any process that activates or increases the frequency, rate or extent of cytolysis.


chitin metabolic process

description: The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.


cytotoxic T cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.


amacrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.


name: negative regulation of centriole replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.


glycerol ether metabolic process

description: The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.


name: positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

description: Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.


name: negative regulation of granulocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.


cobalamin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.


dendritic spine morphogenesis

description: The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


meiotic DNA repair synthesis

description: During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template.


name: regulation of gastro-intestinal system smooth muscle contraction

description: Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.


mitotic DNA replication

description: Any nuclear DNA replication that is involved in a mitotic cell cycle.


description: The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


guanylate cyclase complex, soluble

description: Complex that possesses guanylate cyclase activity and is not bound to a membrane.


Ankle pain

description: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ankle.


eclampsia

description: A potentially life-threatening pregnancy-related disorder characterized by tonic-clonic seizures in association with hypertension after the twentieth week of gestation and up to six weeks postpartum and in the absence of other potential causes of seizures.


name: rRNA (guanine) methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine.


etidocaine

An amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid  and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given by injection during surgical procedures and during labour and delivery.


galactose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.


SCAR complex

description: A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.


immunodeficiency disease

description: Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.


description: Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate.


regulation of vesicle fusion

description: Any process that modulates the frequency, rate or extent of vesicle fusion.


alpha-amylase activity

description: Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.


cervicothoracic ganglion

description: The group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia.


name: G protein-coupled adenosine receptor signaling pathway

description: The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.


clathrin coat of endocytic vesicle

description: A clathrin coat found on an endocytic vesicle.


name: negative regulation of calcium ion import into sarcoplasmic reticulum

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum.


name: positive regulation of T cell differentiation in thymus

description: Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.


name: meiotic attachment of telomere to nuclear envelope

description: The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation.


stress granule disassembly

description: The disaggregation of a stress granule into its constituent protein and RNA parts.


name: cell proliferation in external granule layer

description: The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere.


integrin activation

description: The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.


regulation of cellular glucuronidation

description: Any process that modulates the frequency, rate or extent of cellular glucuronidation.


carbetocin

Oxytocin in which the hydrogen on the phenolic hydroxy group is substituted by methyl, the amino group on the cysteine residue is substituted by hydrogen, and the sulfur of the cysteine residue is replaced by a methylene group. A synthetic carba-analogue of oxytocin, it is used to control bleeding after giving birth. Like oxytocin, it causes contraction of the uterus.


name: negative regulation of dendritic cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.


retinoic acid biosynthetic process

description: The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.


name: regulation of macrophage colony-stimulating factor production

description: Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production.


lumenal side of lysosomal membrane

description: The side (leaflet) of the lysosomal membrane that faces the lumen.


description: The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.


name: positive regulation of exosomal secretion

description: Any process that activates or increases the frequency, rate or extent of exosomal secretion.


description: Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin.


metacycline

A tetracycline that is the 6-methylene analogue of oxytetracycline, obtained by formal dehydration at position 6.


name: purine nucleoside transmembrane transporter activity

description: Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other.


burning mouth syndrome

description: A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth.


carbohydrate phosphatase activity

description: Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate.


endosomal vesicle fusion

description: The homotypic fusion of endocytic vesicles to form or add to an early endosome.


name: transmembrane receptor protein tyrosine phosphatase activity

description: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


trigeminal nucleus

description: A nucleus of brain that is part of a trigeminal nuclear complex.


intracellular phosphate ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell.


description: Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA.


response to isoquinoline alkaloid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.


ribosomal large subunit binding

description: Binding to a large ribosomal subunit.


Back Injuries

description: Trauma to the posterior trunk.


name: hindbrain radial glia guided cell migration

description: The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain.


herpes labialis

description: A lesion caused by type 1 or type 2 herpes simplex virus, typically involving the oralfacial region.


lymphatic system cancer

description: A malignant neoplasm involving the lymphatic part of lymphoid system


regulation of microtubule binding

description: Any process that modulates the frequency, rate or extent of microtubule binding.


regulation of potassium ion import

description: Any process that modulates the frequency, rate or extent of potassium ion import.


regulation of asymmetric cell division

description: Any process that modulates the frequency, rate or extent of asymmetric cell division.


name: telomere maintenance via telomere lengthening

description: Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.


eribulin

A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage


brain renin-angiotensin system

description: The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.


name: negative regulation of icosanoid secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.


(-)-menthol

A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer.


name: positive regulation of cyclin-dependent protein serine/threonine kinase activity

description: Any process that activates or increases the frequency, rate or extent of CDK activity.


biotinidase activity

description: Catalysis of the reaction: biotin amide + H2O = biotin + NH3.


name: pyrimidine ribonucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.


FACT complex

description: A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage.


name: negative regulation of T cell differentiation in thymus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.


ATPase activator activity

description: Binds to and increases the activity of an ATP hydrolysis activity.


name: positive regulation of protein linear polyubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination.


name: positive regulation of macrophage chemotaxis

description: Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


name: regulation of oxidative phosphorylation uncoupler activity

description: Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity.


adenosine to inosine editing

description: The conversion of an adenosine residue to inosine in an RNA molecule by deamination.


melanin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.


suckling behavior

description: Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.


echolalia

description: A symptom of neurologic or psychiatric dysfunction in which the individual involuntarily and meaninglessly repeats a recently heard word, series of words, or a song.


respiratory chain complex II

description: A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.


neural tube patterning

description: The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.


name: regulation of skeletal muscle contraction

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction.


name: regulation of mitochondrial DNA metabolic process

description: Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process.


imipenem

A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.


name: tail-anchored membrane protein insertion into ER membrane

description: A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.


D5 dopamine receptor binding

description: Binding to a D5 dopamine receptor.


protein localization to nucleolus

description: A process in which a protein is transported to, or maintained in, a location within a nucleolus.


name: regulation of dopaminergic neuron differentiation

description: Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation.


name: photoreceptor cell outer segment organization

description: A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.


name: positive regulation of autophagosome assembly

description: Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.


name: pyrimidine- and adenosine-specific:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in).


name: deoxyribonucleoside triphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.


O-acyltransferase activity

description: Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.


name: positive regulation of T-helper 2 cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.


name: negative regulation of protein oligomerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization.


name: negative regulation of execution phase of apoptosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.


metanephric glomerulus development

description: The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros.


Renal infarction

description: Ischemic necrosis of the kidney caused by interruption of the blood supply to the area.


tumor necrosis factor binding

description: Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.


septum primum development

description: The progression of the septum primum over time, from its formation to the mature structure.


stomach polyp

description: A polyp that arises from the stomach. This category includes neoplastic polyps (intestinal-type adenomatous polyps, gastric-type adenomas, and fundic gland polyps), and non-neoplastic polyps (hyperplastic polyps and hamartomatous polyps).


negative regulation of serotonin uptake

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.


name: negative regulation of glucuronosyltransferase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of glucuronosyltransferase activity.


phospholipid translocation

description: The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.


interleukin-12 binding

description: Binding to interleukin-12.


name: negative regulation of DNA recombination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.


protein-glycine ligase activity

description: Catalysis of the reaction: ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H+ + phosphate.


vitamin D catabolic process

description: The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).


plantar fasciitis

description: Inflammation of the thick tissue on the bottom of the foot (plantar fascia) causing heel pain. The plantar fascia (also called plantar aponeurosis) are bands of fibrous tissue extending from the calcaneal tuberosity to the toes. The etiology of plantar fasciitis remains controversial but is likely to involve a biomechanical imbalance. Though often presenting along with heel spur, they do not appear to be causally related.


glycyl-tRNA aminoacylation

description: The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.


name: microtubule nucleation by interphase microtubule organizing center

description: The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation.


name: regulation of single stranded viral RNA replication via double stranded DNA intermediate

description: Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate.


Adverse reactions

description: Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.


scapula

description: Endochondral bone that is dorsoventrally compressed and provides attachment site for muscles of the pectoral appendage.


name: regulation of the force of skeletal muscle contraction

description: Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges.


myelodysplastic syndrome

description: A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)


guanylate cyclase activator activity

description: Binds to and increases the activity of guanylate cyclase.


heme transmembrane transporter activity

description: Enables the transfer of heme from one side of a membrane to the other.


name: extracellular polysaccharide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.


name: regulation of intracellular cholesterol transport

description: Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells.


cellular response to ionomycin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.


leukemoid reaction

description: A hematology test result that indicates the presence of an increased white blood cell count and increased neutrophil precursors resembling leukemia, in a peripheral blood smear.


endothelial cell morphogenesis

description: The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.


hamartoma

description: A benign and excessive tumor-like growth of mature cells and normal tissues which grow in a disorganized pattern.


description: An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein).


name: mitochondrial respiratory chain complex IV

description: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).


butyrylcholinesterase deficiency

description: Butyrylcholinesterase (BChE) deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency.


warfarin

A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.


antral ovarian follicle growth

description: Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.


name: positive regulation of secondary heart field cardioblast proliferation

description: Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).


caffeine oxidase activity

description: Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O.


NADPH dehydrogenase (quinone) activity

description: Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.


microfibril

description: Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.


ethanol metabolic process

description: The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.


name: sugar transmembrane transporter activity

description: Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides.


name: metanephric nephron epithelium development

description: The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros.


nitrogen cycle metabolic process

description: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.


name: positive regulation of cell adhesion mediated by integrin

description: Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.


name: epithelial cell proliferation involved in mammary gland duct elongation

description: The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth.


name: dimethylallyl diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate.


name: establishment of melanosome localization

description: The directed movement of a melanosome to a specific location.


parasitic infectious disease

description: A successful invasion of a host by an organism that uses the host for food and shelter.


oocyte construction

description: The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.


probucol

A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.


cellular response to alkaline pH

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.


regulation of somitogenesis

description: Any process that modulates the frequency, rate or extent of somitogenesis.


protein ufmylation

description: Covalent attachment of the ubiquitin-like protein UFM1 to another protein.


name: positive regulation of aconitate hydratase activity

description: Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.


NADPH-hemoprotein reductase activity

description: Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.


inner cell mass cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.


Dysmetria

description: A type of ataxia characterized by the inability to carry out movements with the correct range and motion across the plane of more than one joint related to incorrect estimation of the distances required for targeted movements.


Epiphyses, Slipped

description: Abnormal separation of an epiphysis from the shaft of a bone.


RNA capping

description: The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts.


fumarate metabolic process

description: The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.


regulation of phagocytosis, engulfment

description: Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


vitamin K metabolic process

description: The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.


cellular response to interleukin-8

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus.


name: regulation of metalloendopeptidase activity

description: Any process that modulates the frequency, rate or extent of metalloendopeptidase activity.


anisindione

A cyclic beta-diketone consisting of indane-1,3-dione having a 4-methoxyphenyl substituent at the 4-position.


area postrema

description: A small, rounded eminence on each side of the fourth ventricle, which receives nerve fibers from the solitary nucleus , spinal cord, and adjacent areas of the medulla. The area postrema lies outside the blood-brain barrier and its functions include acting as an emetic chemoreceptor.


name: Mental disorder due to a general medical condition

description: A category of psychiatric disorders which are the direct physiologic consequence of a general medical condition.


regulation of aerobic respiration

description: Any process that modulates the frequency, rate or extent of aerobic respiration.


name: macrophage colony-stimulating factor receptor binding

description: Binding to a macrophage colony-stimulating factor receptor.


name: calcium:monoatomic cation antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in).


CERF complex

description: An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters.


name: G protein-coupled opsin signaling pathway

description: A G protein-coupled receptor signaling pathway that starts with an opsin being activated by a photon, and ending with the light signal being trasmitted through the synapses. The signal can be transmitted via different Galpha subunits types: Go, Gs, Gq, and Gt.


description: Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide.


nitrate metabolic process

description: The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid.


mRNA modification

description: The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


Gallop rhythm

description: In the normal heart cycle, two heart sounds can be heard by auscultation per cycle: S1 and S2. A gallop rhythm refers to the presence of three or four heart sounds per cardiac cycle, which is said to resemble the gallop of a horse.


name: regulation of very-low-density lipoprotein particle remodeling

description: Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.


riboflavin transport

description: The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins.


name: positive regulation of catecholamine uptake involved in synaptic transmission

description: Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell.


TAP binding

description: Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2.


name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor

description: Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen.


basal dendrite

description: A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon.


regulation of podosome assembly

description: Any process that modulates the frequency, rate or extent of podosome assembly.


T-helper cell differentiation

description: The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.


breast benign neoplasm

description: A non-metastasizing neoplasm arising from the breast parenchyma.


negative regulation of DNA binding

description: Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).


name: negative regulation of activin receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway.


description: Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate.


negative regulation of appetite

description: Any process that reduces appetite.


name: positive regulation of gamma-delta T cell activation

description: Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation.


female meiosis I

description: The cell cycle process in which the first meiotic division occurs in the female germline.


Post-Procedural Pain

description: Pain experienced after a medical intervention through the time expected for associated acute effects to abate.


Fracture of clavicle

description: A traumatic or pathologic injury to the clavicle in which the continuity of the clavicle is broken.


description: The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.


response to mercury ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.


name: negative regulation of cellular extravasation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.


protein localization to kinetochore

description: Any process in which a protein is transported to, or maintained at, the kinetochore.


Sertoli cell development

description: The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate.


lung secretory cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.


name: negative regulation of glucose transmembrane transport

description: Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

description: Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


TORC2 complex

description: A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.


name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

description: Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.


troponin I binding

description: Binding to troponin I, the inhibitory subunit of the troponin complex.


ocular vascular disorder

description: A disorder that is caused by pathologic changes in the ocular vasculature.


name: transcription elongation by RNA polymerase III

description: The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III.


name: cytochrome-b5 reductase activity, acting on NAD(P)H

description: Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).


name: regulation of macrophage cytokine production

description: Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


dedifferentiation

description: The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors.


name: negative regulation of non-canonical NF-kappaB signal transduction

description: Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade.


description: Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H+.


renal aminoaciduria

description: A group of inherited kidney disorders characterized by the abnormally elevated levels of amino acids in urine. Genetic mutations of transport proteins result in the defective reabsorption of free amino acids at the proximal renal tubules. Renal aminoaciduria are classified by the specific amino acid or acids involved.


dendritic spine neck

description: Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine.


name: positive regulation of nitric-oxide synthase biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.


name: negative regulation of amine metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.


Morphea

description: Isolated patches of hardened skin (scleroderma).


Hemorrhage urinary tract

description: Bleeding originating from any part of the urinary system.


name: regulation of uterine smooth muscle contraction

description: Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction.


phosphopyruvate hydratase complex

description: A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.


name: regulation of cell communication by electrical coupling

description: Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


name: CD4-positive, alpha-beta T cell differentiation involved in immune response

description: The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.


description: Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA.


rRNA transport

description: The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cyclase regulator activity

description: Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction.


vesicle uncoating

description: A protein depolymerization process that results in the disassembly of vesicle coat proteins.


name: negative regulation of G2/M transition of mitotic cell cycle

description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


microsatellite binding

description: Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem.


Raynaud disease

description: An episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease.


mitochondrial fission

description: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


CNTFR-CLCF1 complex

description: A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space.


name: Crouzon syndrome-acanthosis nigricans syndrome

description: Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features and premature synostosis of cranial sutures (Crouzon disease), associated with acanthosis nigricans (AN).


blood coagulation, extrinsic pathway

description: A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.


lipoprotein particle receptor activity

description: Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.