name: mitochondrial cytochrome c oxidase assembly

description: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane.


TAP1 binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein.


cytoplasmic translational termination

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.


description: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+.


name: 'de novo' NAD biosynthetic process from tryptophan

description: The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.


name: T cell proliferation involved in immune response

description: The expansion of a T cell population by cell division as part of an immune response.


CNS metastases

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A malignant neoplasm that has spread to the central nervous system from another anatomic site or system. The majority are carcinomas (usually lung or breast carcinomas).


gamma DNA polymerase complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.


name: modulation by host of viral catalytic activity

description: The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected.


glycerol-3-phosphate metabolic process

description: The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.


name: positive regulation of cholesterol efflux

description: Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate.


name: bundle of His cell to Purkinje myocyte signaling

description: Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte.


regulation of kidney size

description: Any process that modulates the size of a kidney.


name: very-low-density lipoprotein particle receptor binding

description: Binding to a very-low-density lipoprotein receptor.


name: single-stranded DNA 3'-5' DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.


sebum

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Fatty lubricant matter secreted by sebaceous glands, and made of made of triglyceride oils, wax, squalene, and metabolytes of fat-producing cells[BTO,WP].


name: nuclear cyclin-dependent protein kinase holoenzyme complex

description: Cyclin-dependent protein kinase (CDK) complex found in the nucleus.


geranyltranstransferase activity

description: Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.


chronic liver failure

description: Liver failure that develops slowly and gradually for some time, possibly for years, often as the result of cirrhosis, or malnutrition.


Taste salty

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


scleral disorder

description: A disorder affecting the sclera. Examples include inflammatory processes (e.g., scleritis and episcleritis), and degenerative processes. Primary tumors of the sclera are extremely rare.


facial nerve structural organization

description: The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial ophthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.


neonatal abstinence syndrome

description: A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors.


tRNA-intron endonuclease activity

description: Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.


name: regulation of isotype switching to IgG isotypes

description: Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes.


ethanolamine kinase activity

description: Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine.


regulation of ATP biosynthetic process

description: Any process that modulates the frequency, rate or extent of ATP biosynthetic process.


regulation of neuronal action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


mitochondrial degradosome

description: A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.


name: negative regulation of B cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.


Impaired vibratory sensation

description: A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.


description: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.


vocal learning

description: A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.


pancreatic neoplasm

description: A benign or malignant neoplasm involving the pancreas.


name: regulation of thyroid hormone generation

description: Any process that modulates the frequency, rate or extent of thyroid hormone generation.


glutamate decarboxylase activity

description: Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.


name: positive regulation of T-helper 17 type immune response

description: Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.


cellular response to forskolin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.


name: non-canonical Wnt signaling pathway involved in heart development

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time.


duodenitis

description: Acute or chronic inflammation of the duodenum. Causes include bacterial and viral infections and gastroesophageal reflux disease. Symptoms include vomiting and abdominal pain.


pulmonary artery morphogenesis

description: The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.


name: minus-end-directed organelle transport along microtubule

description: The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.


name: receptor localization to non-motile cilium

description: A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium.


DNA rewinding

description: The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA.


name: positive regulation of potassium ion import across plasma membrane

description: Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.


heart trabecula morphogenesis

description: The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


cranial nerve palsy

description: Injury to any of the cranial nerves or their nuclei in the brain resulting in muscle weakness.


name: positive regulation of cellular pH reduction

description: Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell.


name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


name: regulation of retrograde protein transport, ER to cytosol

description: Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol.


CURI complex

description: A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.


RNA transmembrane transporter activity

description: Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.


lipase activator activity

description: Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


diabetes insipidus

description: A disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. It may also be drug-related.


Necrosis of pancreas

description: A necrotic process affecting the pancreas.


keratohyalin granule

description: A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope.


L-aspartate transmembrane transport

description: The directed movement of L-aspartate across a membrane by means of some agent such as a transporter or a pore.


name: box C/D methylation guide snoRNP complex

description: A ribonucleoprotein complex containing a box C/D type RNA that is capable of ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya.


masoprocol

The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.


deuterosome

description: A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles.


uropod organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated.


name: regulation of collagen catabolic process

description: Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.


miRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.


name: testosterone 17-beta-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione.


name: positive regulation of viral budding via host ESCRT complex

description: Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex.


mismatch repair complex binding

description: Binding to a mismatch repair complex.


name: sodium:dicarboxylate symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in).


name: cardiac muscle cell-cardiac muscle cell adhesion

description: The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.


name: heparan sulfate sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate.


oligosaccharyltransferase complex

description: A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.


name: regulation of organelle transport along microtubule

description: Any process that modulates the frequency, rate or extent of organelle transport along microtubule.


activin receptor activity, type I

description: Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.


lipase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.


name: negative regulation of immature T cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation.


name: negative regulation of response to nutrient levels

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels.


name: mature conventional dendritic cell differentiation

description: The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.


name: flavin-dependent sulfhydryl oxidase activity

description: Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins.


RNA 7-methylguanosine cap binding

description: Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.


name: epithelial cell differentiation involved in embryonic placenta development

description: The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer.


positive regulation of amine transport

description: Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


alkaloid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).


mesangial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state.


follicular fluid

description: The fluid surrounding the ovum and granulosa cells in the ovarian follicle.


name: positive regulation of gamma-delta T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.


aorta coarctation

description: Congenital narrowing of a segment of the aorta. Signs and symptoms include hypertension, muscle weakness, shortness of breath, headaches and leg cramps.


mesonephric duct morphogenesis

description: The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros.


ascending aorta morphogenesis

description: The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


XPC complex

description: A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2.


plasma membrane tubulation

description: A membrane tubulation process occurring in a plasma membrane.


NADPH binding

description: Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.


catecholamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


myoblast fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


tolerance induction to self antigen

description: Tolerance induction directed at self antigens.


apolipoprotein A-I binding

description: Binding to apolipoprotein A-I.


thiamylal

A member of the class of  barbiturates that is 2-thioxodihydropyrimidine-4,6(1H,5H)-dione substituted by a pentan-2-yl and prop-2-en-1-yl group at position 5.


B-1 B cell differentiation

description: The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.


activated T cell proliferation

description: The expansion of a T cell population following activation by an antigenic stimulus.


leukotriene B4 catabolic process

description: The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


description: Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.


riboflavin

D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.


chloride ion binding

description: Binding to a chloride ion (Cl-).


regulation of proton transport

description: Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


filamin binding

description: Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


enprofylline

Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.


detection of virus

description: The series of events in which a stimulus from a virus is received and converted into a molecular signal.


name: estradiol 17-beta-dehydrogenase [NAD(P)+] activity

description: Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.


methotrexate transport

description: The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.


axonemal dynein complex

description: A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


brainstem development

description: The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.


mercury ion binding

description: Binding to a mercury ion (Hg2+).


glossopharyngeal nerve morphogenesis

description: The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.


serotonin transport

description: The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.


Clostridium infectious disease

description: Infections with bacteria of the genus clostridium.


interleukin-2 production

description: The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


coronary vasospasm

description: Sudden coronary artery smooth muscle contraction leading to lumen constriction and decreased blood flow.


posterior cerebral artery

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The posterior cerebral artery (PCA) is one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain in human anatomy]. It arises near the intersection of the posterior communicating artery and the basilar artery and connects with the ipsilateral middle cerebral artery (MCA) and internal carotid artery via the posterior communicating artery (PCommA). [WP,unvetted].


name: very long-chain fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.


platelet dense granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.


myeloid cell apoptotic process

description: Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.


description: Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.


regulation of monocyte aggregation

description: Any process that modulates the frequency, rate or extent of monocyte aggregation.


aldosterone metabolic process

description: The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.


name: signal recognition particle, endoplasmic reticulum targeting

description: A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.


name: protein targeting to vacuole involved in autophagy

description: The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm.


necrotizing enterocolitis

description: Necrotizing enterocolitis (NEC) is a devastating disease that affects mostly the intestine of premature infants. The wall of the intestine is invaded by bacteria, which cause local infection and inflammation that can ultimately destroy the wall of the bowel (intestine). Such bowel wall destruction can lead to perforation of the intestine and spillage of stool into the infant's abdomen, which can result in an overwhelming infection and death.


name: positive regulation of hyaluronan biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.


name: diacylglycerol-dependent, calcium-independent serine/threonine kinase activity

description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.


Golgi to lysosome transport

description: The directed movement of substances from the Golgi to lysosomes.


name: regulation of hypoxia-induced intrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.


name: histone H3K36 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein.


benign meningioma

description: A grade I, slowly growing meningioma. Only a minority of tumors recur following complete resection.


perennial allergic rhinitis

description: Allergic rhinitis caused by indoor allergens and lasting year round.


MAP-kinase scaffold activity

description: The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.


cardiac right ventricle formation

description: The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.


name: modulation by host of viral glycoprotein metabolic process

description: A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process.


Gum Infection

description: An acute or chronic infectious process affecting the gums.


name: regulation of store-operated calcium entry

description: Any process that modulates the frequency, rate or extent of store-operated calcium entry.


U4/U6 snRNP

description: A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes.


name: negative regulation of leukocyte tethering or rolling

description: Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling.


Athetosis

description: A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest.


ceramide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid.


ATF4-CREB1 transcription factor complex

description: Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.


L-serine ammonia-lyase activity

description: Catalysis of the reaction: L-serine = pyruvate + NH3.


name: protein kinase A catalytic subunit binding

description: Binding to one or both of the catalytic subunits of protein kinase A.


name: fructose 2,6-bisphosphate metabolic process

description: The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.


BAT3 complex binding

description: Binding to a BAT3 complex.


phylloquinone metabolic process

description: The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1.


internal capsule of telencephalon

description: White matter regional part of brain which is flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem and spinal cord. It consists of three distinct parts: an anterior limb, posterior limb, and genu. (Adapted from MSH by Maryann Martone).


Hypocapnia

description: Abnormally reduced blood carbon dioxide (CO2) level.


methylarsonate reductase activity

description: Catalysis of the reaction: 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acid.


6-phosphofructokinase complex

description: A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.


synaptic transmission, GABAergic

description: The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


expressive language disorder

description: A disorder characterized by an impairment in the development of an individual's expressive language which is in contrast to his/her nonverbal intellect and receptive language development. The impairment may be acquired (i.e., due to a brain lesion or head trauma) or developmental (i.e., no known neurological insult).


peptidyl-cysteine S-trans-nitrosylation

description: Transfer of a nitric oxide (NO) group from one cysteine residue to another.


endosome lumen

description: The volume enclosed by the membrane of an endosome.


nuclear pore cytoplasmic filaments

description: Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component.


dendritic spine maintenance

description: The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.


interleukin-1, type I receptor binding

description: Binding to a Type I interleukin-1 receptor.


name: immune response-inhibiting signal transduction

description: The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.


ectopic germ cell programmed cell death

description: Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.


GDP-L-fucose biosynthetic process

description: The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate.


description: The removal of the ubiquitin group from a monoubiquitinated protein.


response to selenite ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus.


ceramide transport

description: The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.


name: regulation of cell proliferation involved in kidney development

description: Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development.


name: negative regulation of helicase activity

description: Any process that stops or reduces the activity of a helicase.


name: regulation of lamellipodium morphogenesis

description: Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis.


CatSper complex

description: A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.


mediator complex binding

description: Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


DNA primase activity

description: Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer.


somite specification

description: The process in which individual somites establish identity during embryogenesis.


name: glucose:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in).


otolith morphogenesis

description: The process in which the anatomical structures of an otolith are generated and organized.


MutLalpha complex binding

description: Binding to a MutLalpha mismatch repair complex.


mestranol

A terminal acetylenic compound that is (17alpha)-17-ethynylestra-1(10),2,4-triene substituted by a methoxy group at position 3 and a hydroxy group at position 17.


name: positive regulation of natural killer cell degranulation

description: Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation.


luteinizing hormone secretion

description: The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.


name: negative regulation of anion channel activity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity.


name: Ric1-Rgp1 guanyl-nucleotide exchange factor complex

description: A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi.


Blanching

description: Transient pallor of the skin caused by reduced blood flow to the affected region.


positive regulation of mismatch repair

description: Any process that activates or increases the frequency, rate or extent of mismatch repair.


folic acid metabolic process

description: The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.


corneal endothelium

description: A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP].


name: protein localization to microtubule cytoskeleton

description: A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.


L-phenylalanine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.


zymogen granule

description: A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.


name: gamma-aminobutyric acid:sodium:chloride symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in).


icosanoid receptor activity

description: Combining with an icosanoid to initiate a change in cell activity.


meiotic spindle

description: A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.


name: positive regulation of Rac protein signal transduction

description: Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.


name: negative regulation of macrophage activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.


name: positive regulation by host of viral genome replication

description: A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication.


NAD+ nucleosidase activity

description: Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.


name: cellular response to cell-matrix adhesion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.


name: negative regulation of prostaglandin biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


name: protein localization to extracellular region

description: Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location.


desmosome assembly

description: A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


name: response to manganese-induced endoplasmic reticulum stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus.


uterine polyp

description: A benign protruding lesion arising either from the endometrial cavity (endometrial polyp) or the endocervix (endocervical polyp). It may occasionally recur following complete resection.


canalicular bile acid transport

description: Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.


Joint dislocation

description: Displacement or malalignment of joints.


name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

description: Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.


name: positive regulation of cell-matrix adhesion

description: Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.


name: vascular endothelial growth factor receptor 1 binding

description: Binding to a vascular endothelial growth factor receptor 1.


name: negative regulation of protein K63-linked ubiquitination

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination.


regulation of membrane tubulation

description: Any process that modulates the frequency, rate or extent of membrane tubulation.


cellular response to peptidoglycan

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.


metanephric nephron tubule development

description: The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.


piRNA binding

description: Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.


pyridoxine metabolic process

description: The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


Hyperphosphaturia

description: An increased excretion of phosphates in the urine.


GARP complex

description: A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.


cardiac Purkinje fiber

description: The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.


name: proton-transporting ATP synthase complex, catalytic core F(1)

description: The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.


iron-responsive element binding

description: Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins.


DNA replication, removal of RNA primer

description: Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.


name: determination of digestive tract left/right asymmetry

description: Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed.


name: iron ion transmembrane transporter activity

description: Enables the transfer of iron (Fe) ions from one side of a membrane to the other.


phospholipid homeostasis

description: Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.


Ridged nail

description: Longitudinal, linear prominences in the nail plate.


FANCM-MHF complex

description: A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes.


neuronal signal transduction

description: The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.


name: protein localization to basolateral plasma membrane

description: Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane.


malate metabolic process

description: The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.


name: positive regulation of ureteric bud formation

description: Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct.


urate transport

description: The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


citrullinemia

description: Citrullinemia is an autosomal recessively inherited disorder of urea cycle metabolism and ammonia detoxification characterized by elevated concentrations of serum citrulline and ammonia. The disease presents with a large range of manifestations including neonatal hyperammonemic encephalopathy with lethargy, seizures and coma; hepatic dysfunction in all age groups; episodes of hyperammonemia and neuropsychiatric symptoms in children or adults, or, can be asymptomatic in some cases (detected in newborn screening programs). Citrullinemia is divided into two main groups that are encoded by different genes: citrullinemia type I (comprised of acute neonatal citrullinemia type I and adult-onset citrullinemia type I) and citrin deficiency (comprised of adult-onset citrullinemia type II and neonatal intrahepatic cholestasis due to citrin deficiency).


3'-UTR-mediated mRNA destabilization

description: An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.


Toll signaling pathway

description: The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


mimosine

An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.


name: inositol hexakisphosphate 1-kinase activity

description: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate.


fatty acid alpha-oxidation

description: A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.


NADP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH.


name: regulation of T cell mediated immune response to tumor cell

description: Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell.


articular capsule

description: An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].


name: negative regulation of low-density lipoprotein particle receptor catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.


facial spasm

description: Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face.


name: positive regulation of microtubule depolymerization

description: Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.


glycolipid mannosyltransferase activity

description: Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.


cell tip

description: The region at the end of the longest axis of a cylindrical or elongated cell.


Infusion-Related Reaction

description: A reaction to the infusion of pharmacological or biological substances. Symptoms may appear within minutes to hours following the infusion and may include pruritus, flushing, swelling, dyspnea, bronchospasm, and hypotension.


stress-induced premature senescence

description: A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.


deNEDDylase activity

description: An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.


name: endothelial differentiation G protein-coupled receptor binding

description: Binding to an endothelial differentiation G protein-coupled receptor.


tRNA methyltransferase complex

description: A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.


eosinophil chemotaxis

description: The movement of an eosinophil in response to an external stimulus.


name: regulation of definitive erythrocyte differentiation

description: Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis.


description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.


fibroblast migration

description: Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.


peptide amidation

description: The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions.


proline metabolic process

description: The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.


name: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

description: The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.


fibroblast proliferation

description: The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.


Y chromosome

description: The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.


name: positive regulation of antibacterial peptide biosynthetic process

description: Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.


inner dynein arm assembly

description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


name: negative regulation of amino acid transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


prosthetic group metabolic process

description: The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.


name: regulation of CD8-positive, alpha-beta T cell extravasation

description: Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation.


NatB complex

description: A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.


stria vascularis of cochlear duct

description: The upper portion of the spiral ligament contains numerous capillary loops and small blood vessels, and is termed the stria vascularis. It produces endolymph for the scala media, one of the three fluid-filled compartments of the cochlea. [WP,unvetted].


name: azole transmembrane transporter activity

description: Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other.


alcoholic liver cirrhosis

description: A disorder of the liver characterized by the presence of fibrotic scar tissue instead of healthy liver tissue. This condition is attributed to excessive consumption of alcoholic beverages.


name: regulation of nucleobase-containing compound transport

description: Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


lingual-facial-buccal dyskinesia

description: Syndromes which feature dyskinesias as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.


varicosity

description: Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.


CUT catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs).


nucleobase binding

description: Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.


peptidyl-serine autophosphorylation

description: The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.


name: cellular response to methyl methanesulfonate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus.


name: regulation of dopamine receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


name: pyruvate dehydrogenase (acetyl-transferring) kinase activity

description: Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.


olecranon bursitis

description: A bursitis that involves the olecranon.


homocysteine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.


name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


pre-miRNA binding

description: Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.


name: negative regulation of protein localization to cell surface

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface.


MHC class Ib receptor activity

description: Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


name: mammary gland epithelial cell differentiation

description: The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.


chondroitin 4-sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.


name: inhibitory MHC class I receptor activity

description: Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte.


circadian sleep/wake cycle

description: The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.


T-helper 17 type immune response

description: An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22.


coumarin metabolic process

description: The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids.


Flight of ideas

description: Successive thoughts and speech are easily diverted by external stimuli or internal superficial associations.


name: negative regulation of hair follicle development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development.


epsilon DNA polymerase complex

description: A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.


name: post-embryonic retina morphogenesis in camera-type eye

description: The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage.


thyroxine 5'-deiodinase activity

description: Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.


copper ion import

description: The directed movement of copper ions into a cell or organelle.


Episcleritis

description: Inflammation of the episclera, a thin layer of tissue covering the white part (sclera) of the eye.


name: negative regulation of inorganic anion transmembrane transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport.


nystatin

A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.


banded collagen fibril

description: A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands).


response to symbiont

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


tipranavir

A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor.


malathion

A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.


glutamate binding

description: Binding to glutamate, the anion of 2-aminopentanedioic acid.


prostatic bud formation

description: The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.


CCR5 chemokine receptor binding

description: Binding to a CCR5 chemokine receptor.


otic vesicle formation

description: The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.


carnitine metabolic process, CoA-linked

description: The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.


herpangina

description: A viral infectious disease that results in infection located in mouth, has material basis in Human coxsackievirus A16, has material basis in Human enterovirus 71, has material basis in group B coxsackievirus, or has material basis in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.


skin carcinoma

description: A carcinoma that arises from epithelial cells of the zone of skin


hyperpigmentation of eyelid

description: Over-production of pigment in the eyelid.


myosin heavy chain binding

description: Binding to a heavy chain of a myosin complex.


astrocyte fate commitment

description: The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte.


name: negative regulation of syncytium formation by plasma membrane fusion

description: Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.


chondroitin sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate.


renal filtration cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


intestinal lipid absorption

description: A process in which lipids are taken up from the contents of the intestine.


specification of axis polarity

description: The pattern specification process in which the polarity of a body or organ axis is established and maintained.


cranial suture

description: Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture.


paraxial mesoderm morphogenesis

description: The process in which the anatomical structures of the paraxial mesoderm are generated and organized.


name: positive regulation of peptidyl-tyrosine autophosphorylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.


gastric motility

description: The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum.


name: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity

description: Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH.


creatine

A glycine derivative having methyl and amidino groups attached to the nitrogen.


name: vitamin K deficiency hemorrhagic disease

description: Deficiency of vitamin K. It may lead to bleeding, manifested with ecchymoses, petechiae, and hematomas. In infants it may cause hemorrhagic disease of newborn with intracranial and retroperitoneal bleeding.


name: synaptic assembly at neuromuscular junction

description: The assembly of a synapse at a neuromuscular junction.


sclerotome development

description: The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.


name: negative regulation of steroid hormone biosynthetic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.


name: nicotinate-nucleotide diphosphorylase (carboxylating) activity

description: Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate.


interleukin-8 receptor activity

description: Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: piccolo histone acetyltransferase complex

description: A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.


alanine-oxo-acid transaminase activity

description: Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid.


hereditary myoglobinuria

description: The presence of myoglobin in the urine.


diabetic neuropathy

description: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.


name: ubiquitin-protein transferase activator activity

description: Binds to and increases the activity of a ubiquitin-protein transferase.


positive regulation of heat generation

description: Any process that activates or increases the rate or extent of heat generation.


neurofibrillary tangle

description: Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.


name: regulation of aconitate hydratase activity

description: Any process that modulates the frequency, rate or extent of aconitate hydratase activity.


keratin filament binding

description: Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.


Skin nodule

description: Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat.


description: A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).


hypogonadism

description: A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation.


basilar membrane of cochlea

description: A stiff structural element that separates two liquid-filled tubes that run along the coil of the cochlea, the scala media and the scala tympani[WP].


cellular response to erythropoietin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus.


hexose phosphate transport

description: The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


NatC complex

description: A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.


description: A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).


name: purine deoxyribonucleoside triphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.


name: negative regulation of cell adhesion involved in substrate-bound cell migration

description: The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction.


positive regulation of TRAIL production

description: Any process that activates or increases the frequency, rate, or extent of TRAIL production.


name: cell-matrix adhesion involved in ameboidal cell migration

description: The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.


somatostatin receptor activity

description: Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).


isoquinoline alkaloid metabolic process

description: The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.


endolysosome

description: An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.


name: G protein-coupled receptor catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor.


Paroxysmal hypertension

description: Hypertension that presents intermittently.


alpha-1B adrenergic receptor binding

description: Binding to an alpha-1B adrenergic receptor.


anthrax infection

description: An infection caused by Bacillus anthracis bacteria. It may affect the lungs, gastrointestinal tract, or skin. Patients with lung infection present with fever, headaches, cough, chest pain and shortness of breath. Patients with gastrointestinal infection present with nausea, vomiting and bloody diarrhea. Patients with skin infection develop blisters and ulcers.


name: negative regulation of transcription by transcription factor localization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.


NURF complex

description: An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters.


name: positive regulation of respiratory burst involved in inflammatory response

description: Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


name: calcium-dependent protein serine/threonine kinase activity

description: Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.


condensin complex

description: A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis.


peptidyl-arginine omega-N-methylation

description: The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein.


name: negative regulation of monocyte chemotactic protein-1 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.


otic placode formation

description: The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.


nucleotidase activity

description: Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.


polysaccharide digestion

description: The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.


CAAX-box protein processing

description: The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis.


death-inducing signaling complex

description: A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.


positive regulation of vasculogenesis

description: Any process that activates or increases the frequency, rate or extent of vasculogenesis.


threonine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).


acetate ester metabolic process

description: The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.


response to UV-A

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.


description: Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides.


Brain Concussion

description: A violent jar or shock, or the condition which results from such an injury.


negative regulation of mucus secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.


mitochondrial mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.


name: calcium- and calmodulin-responsive adenylate cyclase activity

description: Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.


name: regulation of heart rate by chemical signal

description: The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine

description: The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine.


name: regulation of antimicrobial peptide biosynthetic process

description: Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis.


response to sorbitol

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.


microspike assembly

description: Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.


name: extrinsic component of omegasome membrane

description: The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


depurination

description: The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.


embryonic hindgut morphogenesis

description: The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase.


bile acid secretion

description: The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.


fatty acid synthase activity

description: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.


Abnormal erythrocyte morphology

description: Any structural abnormality of erythrocytes (red-blood cells).


iron coordination entity transport

description: The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


localized scleroderma

description: Localized scleroderma is the skin localized form of scleroderma characterized by fibrosis of the skin causing cutaneous plaques or strips.


protein unfolding

description: The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.


melanocytic nevus

description: A neoplasm composed of melanocytes that usually appears as a dark spot on the skin.


name: growth plate cartilage chondrocyte differentiation

description: The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.


circadian sleep/wake cycle, sleep

description: The part of the circadian sleep/wake cycle where the organism is asleep.


histidine transport

description: The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


description: Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.


regulation of mRNA export from nucleus

description: Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm.


name: establishment or maintenance of actin cytoskeleton polarity

description: Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.


name: G-protein activated inward rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.


glycogen phosphorylase activity

description: Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.


uridylyltransferase activity

description: Catalysis of the transfer of an uridylyl group to an acceptor.


RNA import into nucleus

description: The import of RNA from the cytoplasm to the nucleus.


name: negative regulation of nitric oxide metabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process.


closure of optic fissure

description: The closure of the temporary ventral gap in the optic cup that contributes to its shaping.


alpha-ketoacid dehydrogenase complex

description: A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present.


name: regulation of synaptic vesicle fusion to presynaptic active zone membrane

description: Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.


name: negative regulation of neutrophil migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration.


name: regulation of hydrogen peroxide biosynthetic process

description: Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


chronic graft versus host disease

description: Chronic graft versus host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body. Symptoms may include skin rash, mouth sores, dry eyes, liver inflammation, development of scar tissue in the skin and joints, and damage to the lungs. The exact cause of chronic GVHD is unknown.It likely results from a complex immune-mediated interaction between the donor and recipient cells.Chronic GVHD is treated with prednisone or other similar anti-inflammatory or immunosuppressive medications.


name: regulation of caveolin-mediated endocytosis

description: Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis.


meiotic cytokinesis

description: A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.


Junctional bradycardia

description: An electrocardiographic finding of a junctional rhythm with a heat rate which is abnormally low. (CDISC)


drug-induced liver injury

description: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to acute liver failure, caused by drugs, drug metabolites, and chemicals from the environment.


demecarium

The bis(quaternary ammonium) dication obtained by N,N'-dimethylation of the N,N'-bis[3-(dimethylamino)phenyl carbamate] derivative of 2,13-diazatetradecane.


leptin receptor binding

description: Binding to a leptin receptor.


Gtr1-Gtr2 GTPase complex

description: A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins.


G-quadruplex DNA binding

description: Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.


Abnormal heart sound

description: Any abnormal noise generated by the beating heart.


complement receptor activity

description: Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


description: Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.


name: MOZ/MORF histone acetyltransferase complex

description: A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.


mesodermal cell fate specification

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


sulfinoalanine decarboxylase activity

description: Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2.


Erythroid hyperplasia

description: Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.


name: cerebral cortex GABAergic interneuron development

description: The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.


Detachment psychological

category: biolink:Behavior biolink:OntologyClass biolink:ActivityAndBehavior biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


migraine without aura

description: A migraine disorder characterized by episodes that occur in the absence of preceding focal neurological symptoms.


P-type calcium transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).


COPII vesicle coat

description: One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.


name: protein O-linked glycosylation via threonine

description: The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine.


sulfate transmembrane transport

description: The directed movement of sulfate across a membrane.


sulfate assimilation

description: The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.


name: potassium:proton exchanging ATPase complex

description: A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present.


isocitrate metabolic process

description: The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.


cellular response to vitamin K

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.


name: regulation of endothelial cell chemotaxis to fibroblast growth factor

description: Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor.


name: negative regulation of phospholipase activity

description: Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.


name: pteridine-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.


inhibitory synapse

description: A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.


Ral protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the RaI subfamily relays a signal.