description: The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.


neuropeptide receptor binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to a neuropeptide receptor.


GTP metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways involving GTP, guanosine triphosphate.


description: The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine.


response to thyroid hormone

description: A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.


neural plate pattern specification

description: The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate.


lymphadenitis

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Acute or chronic inflammation of one or more lymph nodes. It is usually caused by an infectious process.


xanthine metabolic process

description: The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.


name: regulation of interleukin-1 alpha production

description: Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production.


name: peripheral nervous system axon regeneration

description: The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury.


Soft Tissue Infection

description: A bacterial infectious process affecting the soft tissues. A severe form caused by anaerobic or aerobic bacteria is associated with soft tissues necrosis and affects the subcutaneous adipose tissue, muscles, fascia, and the skin.


Fetal distress

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.


name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide.


name: cerebellar Purkinje cell layer development

description: The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


name: negative regulation of cell fate specification

description: Any process that restricts, stops or prevents a cell from adopting a specific cell fate.


name: negative regulation of T-helper 17 cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation.


uracil DNA N-glycosylase activity

description: Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.


name: positive regulation of lipoprotein particle clearance

description: Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


name: protein quality control for misfolded or incompletely synthesized proteins

description: The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.


description: The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.


name: glycine decarboxylation via glycine cleavage system

description: The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.


epiboly

description: The expansion of one cell sheet over other cells or yolk.


lamellar body membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.


name: regulation of intestinal cholesterol absorption

description: Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.


name: nucleoside diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.


lysosome localization

description: Any process in which a lysosome is transported to, and/or maintained in, a specific location.


name: phosphogluconate dehydrogenase (decarboxylating) activity

description: Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.


positive regulation of telomere capping

description: Any process that activates or increases the frequency, rate or extent of telomere capping.


regulation of t-circle formation

description: Any process that modulates the frequency, rate or extent of t-circle formation.


cellular pigment accumulation

description: The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus.


programmed DNA elimination

description: A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing.


regulation of chromatin binding

description: Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


name: negative regulation of transcription initiation by RNA polymerase II

description: Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.


name: regulation of melanin biosynthetic process

description: Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.


psychogenic polydipsia

description: A form of primary polydipsia caused by underlying psychiatric symptoms, including those caused by psychoses and rarely by affective disorders.


exo-alpha-(2->6)-sialidase activity

description: Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates.


telomeric repeat-containing RNA binding

description: Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats.


5'-3' DNA helicase activity

description: Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis.


protein hydroxylation

description: The addition of a hydroxy group to a protein amino acid.


maintenance of blood-brain barrier

description: Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.


name: positive regulation of killing of cells of another organism

description: Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism.


cellular response to nicotine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.


dorsal aorta development

description: The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.


name: ventral spinal cord interneuron specification

description: The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.


aldehyde oxidase activity

description: Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.


negative regulation of macroautophagy

description: Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.


procyclidine

A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.


name: nicotinamide nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.


acute stress disorder

description: An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by dissociative symptoms; vivid recollections of the traumatic event; avoidance of stimuli associated with the traumatic event; and a constant state of hyperarousal for no more than one month.


physiological muscle hypertrophy

description: The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.


ligand-gated sodium channel activity

description: Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


metastatic melanoma

description: A melanoma that has spread from its primary site to another anatomic site. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.


kinesin binding

description: Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.


name: regulation of dendritic cell cytokine production

description: Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.


name: fatty acid elongation, unsaturated fatty acid

description: Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced.


Hemothorax

description: The presence of blood in the pleural space.


description: Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.


pre-B cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.


CCR7 chemokine receptor binding

description: Binding to a CCR7 chemokine receptor.


name: central nervous system projection neuron axonogenesis

description: Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.


chromosome condensation

description: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.


lung carcinoma

description: A carcinoma that arises from epithelial cells of the lung


name: regulation of heterotypic cell-cell adhesion

description: Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion.


name: symbiont-mediated perturbation of host programmed cell death

description: A process in which a symbiont gene product alters or subverts host programmed cell death, leading to a change in the frequency, rate or extent of host programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.


ovarian cumulus expansion

description: Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.


regulation of mRNA catabolic process

description: Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


name: negative regulation of t-circle formation

description: Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.


cysteine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid.


protein K6-linked ubiquitination

description: A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair.


name: ventral spinal cord interneuron fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


name: positive regulation of endoplasmic reticulum unfolded protein response

description: Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


name: positive regulation of uterine smooth muscle contraction

description: Any process that increases the frequency, rate or extent of uterine smooth muscle contraction.


name: clathrin-coated endocytic vesicle membrane

description: The lipid bilayer surrounding a clathrin-coated endocytic vesicle.


submandibular salivary gland formation

description: The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed.


keratin filament

description: A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.


nitric oxide metabolic process

description: The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.


name: proton-transporting V-type ATPase complex assembly

description: The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient.


name: inherited bleeding disorder, platelet-type


name: negative regulation of glucocorticoid metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


phenylpropanoid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid.


Fuchs' endothelial dystrophy

description: Fuchs endothelial corneal dystrophy (FECD) is the most frequent form of posterior corneal dystrophy and is characterized by excrescences on a thickened Descemet membrane (corneal guttae), generalized corneal edema, with gradually decreased visual acuity.


dermoid cyst

description: A mature teratoma characterized by the presence of a cyst which is lined by mature tissue resembling the epidermis and the epidermal appendages. It occurs in the ovary, testis, and extragonadal sites including central nervous system and skin.


name: regulation of extracellular exosome assembly

description: Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.


carnitine O-acyltransferase activity

description: Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule.


name: regulation of cyclic-nucleotide phosphodiesterase activity

description: Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.


catecholamine transport

description: The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


name: regulation of delayed rectifier potassium channel activity

description: Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.


name: late endosome to vacuole transport via multivesicular body sorting pathway

description: The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.


positive regulation of glucose import

description: Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.


microvillus assembly

description: Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.


name: positive regulation of extracellular matrix organization

description: Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.


name: pyrimidine dimer repair by nucleotide-excision repair

description: The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.


potassium channel regulator activity

description: Binds to and modulates the activity of a potassium channel.


L-cystine

The L-enantiomer of the sulfur-containing amino acid cystine.


name: positive regulation of synaptic vesicle transport

description: Any process that activates or increases the frequency, rate or extent of synaptic vesicle transport.


Bone marrow hyperplasia

description: Increase in the number of hematopoietic cells in the bone marrow. It may involve all or individual hematopoietic cell lines.


sulfate transport

description: The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Abnormality of fluid regulation

description: An abnormality of the regulation of body fluids.


Abnormal bowel sounds

description: An anomaly of the amount or nature of abdominal sounds. Abdominal sounds (bowel sounds) are made by the movement of the intestines as they promote passage of abdominal contents by peristalsis.


name: negative regulation of nitric-oxide synthase biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme.


congenital hypothyroidism

description: A thyroid hormone deficiency present from birth.


name: regulation of memory T cell differentiation

description: Any process that modulates the frequency, rate, or extent of memory T cell differentiation.


name: regulation of synapse structural plasticity

description: Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane.


name: regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

description: Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.


cytosolic proteasome complex

description: A proteasome complex found in the cytosol of a cell.


creatinine metabolic process

description: The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine.


granulomatous hepatitis

description: Hepatitis that is characterized by the presence of granulomas.


hepoxilin-epoxide hydrolase activity

description: Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.


name: skeletal muscle acetylcholine-gated channel clustering

description: The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.


extranodal nasal NK/T cell lymphoma

description: Extranodal nasal NK/T cell lymphoma (NKTCL) is a rare, malignant neoplasm mainly affecting men in the fifth decade of life, that usually arises in the nose, paranasal sinuses, orbits or upper airway, and that can present with a nasal mass, nasal bleeding, nasal obstruction, palate perforation (i.e. midline perforation of the hard palate), and mid-facial and/or upper airway destructive lesions. In advanced disease stages, which are associated with a poor prognosis, NKTCL may disseminate to other organs. A few cases of NKTCL presenting primarily in the lymph nodes have also been described.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.


triglyceride binding

description: Binding to a triester of glycerol.


histone H3K14 deacetylase activity

description: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.


regulation of action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


positive regulation of hair cycle

description: Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.


neural plate development

description: The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.


name: positive regulation of fibroblast growth factor receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.


category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


ribosome disassembly

description: The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.


hyperosmotic salinity response

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


somatic motor neuron differentiation

description: The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


sialic acid binding

description: Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.


name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.


name: regulation of centromeric sister chromatid cohesion

description: Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome.


name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


acute myeloid leukemia

description: Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.


Ejection Fraction Decreased

description: A finding indicating a decrease in the volume of blood ejected during ventricular heart contraction.


histamine secretion

description: The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.


name: regulation of phospholipid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids.


name: regulation of epithelial cell differentiation involved in kidney development

description: Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development.


name: positive regulation of signal transduction by p53 class mediator

description: Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.


name: regulation of skeletal muscle cell proliferation

description: Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.


name: regulation of amino acid import across plasma membrane

description: Any process that modulates the frequency, rate or extent of amino acid import into a cell.


oculomotor nerve paralysis

description: Paralysis of the oculomotor nerve.


name: regulation of cell proliferation in bone marrow

description: A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow.


name: xenobiotic transmembrane transporter activity

description: Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


name: positive regulation of determination of dorsal identity

description: Any process that activates or increases the frequency, rate or extent of determination of dorsal identity.


name: Infection and inflammatory reaction due to internal orthopedic fixation device

description: An infectious process involving an implanted medical device and the surrounding tissues.


bopindolol

A methylindole that is 2-methyl-1H-indol-4-ol in which the hydrogen of the hydroxy group is replaced by a 2-(benzoyloxy)-3-(tert-butylamino)propyl group.


appendicitis

description: Acute inflammation of the vermiform appendix.


germ plasm

description: Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.


oxygen transport

description: The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


intracellular copper ion homeostasis

description: A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell.


name: regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

description: Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation.


motor neuron axon guidance

description: The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.


pituitary gland adenoma

description: A non-metastasizing tumor that arises from the adenohypophysial cells of the anterior lobe of the pituitary gland. The tumor can be hormonally functioning or not. The diagnosis can be based on imaging studies and/or radioimmunoassays. Due to its location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss.


name: glucosamine-containing compound metabolic process

description: The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines).


glial cell apoptotic process

description: Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.


name: cell migration involved in heart development

description: The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.


name: hyperphenylalaninemia due to tetrahydrobiopterin deficiency

description: Hyperphenylalaninemia (HPA) due to tetrahydrobiopterin (BH4) deficiency, also known as malignant HPA is an amino acid disorder with neonatal onset that is clinically characterized by the classic manifestations of phenylketonuria (PKA) and that later on is clinically differentiated by neurologic symptoms such as microcephaly, intellectual disability, central hypotonia, delayed motor development, peripheral spasticity and seizures, that develop and persist despite an established metabolic control of plasma phenylalanine.


name: negative regulation of autophagosome maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation.


cellular response to interleukin-7

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.


name: positive regulation of sprouting angiogenesis

description: Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.


protein K6-linked deubiquitination

description: A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein.


Cajal body organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.


description: Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate.


description: Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site.


regulation of DNA endoreduplication

description: Any process that modulates the frequency, rate or extent of DNA endoreduplication.


Stress

description: The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities.


name: positive regulation of alcohol biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process.


lateral inhibition

description: Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.


name: regulation of interleukin-1-mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway.


Corneal erosion

description: An erosion or abrasion of the cornea's outermost layer of epithelial cells.


Atrial arrhythmia

description: A type of supraventricular tachycardia in which the atria are the principal site of electrophysiologic disturbance.


name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


catenin-TCF7L2 complex

description: A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


tRNA transcription

description: The synthesis of transfer RNA (tRNA) from a DNA template.


name: negative regulation of lipoprotein lipase activity

description: Any process that stops or reduces the activity of the enzyme lipoprotein lipase.


protein K48-linked deubiquitination

description: A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.


name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

description: The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade.


cholangiocyte proliferation

description: The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.


central nervous system cancer

description: A malignant neoplasm involving the central nervous system


ethanol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.


name: negative regulation of dendrite morphogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis.


chemorepulsion of axon

description: The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


name: regulation of ATPase-coupled calcium transmembrane transporter activity

description: Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.


epicondylitis

description: Inflammation of the lateral epicondyle.


name: positive regulation of substrate adhesion-dependent cell spreading

description: Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.


response to testosterone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.


paranodal junction

description: A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.


creatine kinase activity

description: Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H+.


GINS complex

description: A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.


regulation of osteoclast development

description: Any process that modulates the frequency, rate or extent of osteoclast development.


name: positive regulation of cell fate commitment

description: Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


name: negative regulation of neurotransmitter secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.


name: regulation of cell-cell adhesion mediated by integrin

description: Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin.


name: nucleoside triphosphate diphosphatase activity

description: Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.


name: regulation of circadian sleep/wake cycle, non-REM sleep

description: Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.


Polydipsia

description: Excessive thirst manifested by excessive fluid intake.


germinal vesicle

description: The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.


name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

description: Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.


cortical endoplasmic reticulum

description: A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.


atrioventricular node

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.


neuronal ribonucleoprotein granule

description: A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.


radial artery

description: Branch of the brachial artery beginning below the elbow and extending down the forearm around the wrist and into the palm.


name: negative regulation of endothelial cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.


name: learned vocalization behavior or vocal learning

description: Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned.


name: protein localization to chromosome, telomeric region

description: Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.


name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

description: Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.


energy homeostasis

description: Any process involved in the balance between food intake (energy input) and energy expenditure.


name: selenocysteine insertion sequence binding

description: Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.


name: positive regulation of cardiac muscle hypertrophy

description: Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.


CCR10 chemokine receptor binding

description: Binding to a CCR10 chemokine receptor.


protein desumoylation

description: The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.


cochlear nucleus development

description: The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.


laminin binding

description: Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells.


pyrimidine nucleotide binding

description: Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate.


COPI vesicle coat

description: One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.


name: negative regulation of fatty acid beta-oxidation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.


SODIUM TETRADECYL SULFATE

An organic sodium salt having tetradecyl sulfate as the counterion. Used in the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.


urea transport

description: The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.


name: cell wall macromolecule metabolic process

description: The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.


name: central nervous system myelin maintenance

description: The process in which the structure and material content of mature central nervous system myelin is kept in a functional state.


name: positive regulation of phagocytosis, engulfment

description: Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.


name: auditory receptor cell stereocilium organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.


type 1 angiotensin receptor binding

description: Binding to a type 1 angiotensin receptor.


name: ATP-dependent polynucleotide 5'-hydroxyl-kinase activity

description: Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.


vitamin D metabolic process

description: The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).


quinolinate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.


negative regulation of neuron migration

description: Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.


multivesicular body membrane

description: The lipid bilayer surrounding a multivesicular body.


negative regulation of hippo signaling

description: Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.


tRNA 3'-end processing

description: The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.


face

description: A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc).


aldehydo-N-acetyl-D-glucosamine

The open-chain form of N-acetyl-D-glucosamine.


name: positive regulation of autophagy of mitochondrion

description: Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy.


name: positive regulation of cell proliferation in bone marrow

description: A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.


NLRP3 inflammasome complex

description: An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.


bleb

description: A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.


description: Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.


name: regulation of platelet-derived growth factor production

description: Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: iodide transmembrane transporter activity

description: Enables the transfer of iodide ions from one side of a membrane to the other.


xenobiotic glucuronidation

description: The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion.


carbuncle

description: An infection of cutaneous and subcutaneous tissue that consists of a cluster of boils. Commonly, the causative agent is staphylococcus aureus. Carbuncles produce fever, leukocytosis, extreme pain, and prostration.


protein localization to membrane raft

description: A process in which a protein is transported to, or maintained in, a location within a membrane raft.


P granule

description: A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.


mitochondrial protein catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure.


name: regulation of mineralocorticoid secretion

description: Any process that modulates the frequency, rate or extent of mineralocorticoid secretion.


Vitreous hemorrhage

description: Bleeding within the vitreous compartment of the eye.


oligodendrocyte development

description: The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.


acetylcholine receptor activity

description: Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


thiamine

A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.


cell wall organization or biogenesis

description: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.


postsynaptic membrane assembly

description: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


name: ciliary receptor clustering involved in smoothened signaling pathway

description: Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway.


iron deficiency anemia

description: Anemia caused by low iron intake, inefficient iron absorption in the gastrointestinal tract, or chronic blood loss.


name: CD4-positive, alpha-beta T cell lineage commitment

description: The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell.


nonsyndromic congenital nail disorder 9

description: Deformity or discoloration of a fingernail or toenail.


interleukin-4 production

description: The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


name: regulation of long-term neuronal synaptic plasticity

description: A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.


Hyperemia

description: The presence of an increased amount of blood in a part or organ; engorgement.


regulation of collateral sprouting

description: Any process that modulates the frequency, rate or extent of collateral sprouting.


name: SA node cell to atrial cardiac muscle cell communication

description: The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


name: cerebellar Purkinje cell layer structural organization

description: The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


microtubule end

description: Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end.


third ventricle development

description: The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina.


Knee pain

description: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee.


Arthralgia of the hip

description: Joint pain affecting the hip.


integrin alpha8-beta1 complex

description: An integrin complex that comprises one alpha8 subunit and one beta1 subunit.


outer dynein arm

description: Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


name: cell communication by electrical coupling involved in cardiac conduction

description: The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.


name: purine deoxyribonucleoside metabolic process

description: The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).


description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in).


name: negative regulation of digestive system process

description: Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


fatty-acyl-CoA biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.


D-cycloserine

A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and  D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).


ferroxidase activity

description: Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.


Granuloma

description: A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.


platelet aggregation

description: The adhesion of one platelet to one or more other platelets via adhesion molecules.


superoxide anion generation

description: The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.


CCR2 chemokine receptor binding

description: Binding to a CCR2 chemokine receptor.


name: positive regulation of protein localization to Cajal body

description: Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.


DNA clamp loader activity

description: Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.


heme a metabolic process

description: The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3.


hereditary fructose intolerance

description: Hereditary fructose intolerance (HFI) is an autosomal recessive disorder of fructose metabolism, resulting from a deficiency of hepatic fructose-1-phosphate aldolase activity and leading to gastrointestinal disorders and postprandial hypoglycemia following fructose ingestion. HFI is a benign condition when treated, but it is life-threatening and potentially fatal if left untreated.


name: negative regulation of cardiac muscle hypertrophy in response to stress

description: Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.


name: apoptotic process involved in development

description: Any apoptotic process that is involved in anatomical structure development.


name: negative regulation of sprouting angiogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.


Lyme disease

description: Lyme disease (named after the towns in the USA where the disease was first identified) is a bacterial infection caused by Borrelia burgdorferi.


retinopathy of prematurity

description: A bilateral retinopathy characterized by neovascularization, scarring, retinal detachment, and eventually blindness. It may be mild or severe. It occurs in babies born prematurely. Causes include oxygen toxicity and hypoxia.


ionotropic glutamate receptor binding

description: Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.


hepatic vein

description: Vein that carries blood away from the liver[ZFA].


AMP binding

description: Binding to AMP, adenosine monophosphate.


metabolic disease

description: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.


cytoskeletal calyx

description: A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins.


protein exit from endoplasmic reticulum

description: The directed movement of proteins from the endoplasmic reticulum.


name: postural orthostatic tachycardia syndrome

description: A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart.


osteoblast fate commitment

description: The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.


Fasciculations

description: Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units.


megaloblastic anemia

description: Anemia characterized by the presence of unusually large erythroblasts in the bone marrow called megaloblasts. It is usually caused by vitamin B12 or folic acid deficiency. Other causes include toxins and drugs.


ferritin complex

description: A protein complex that binds iron and acts as a major iron storage system. There are three major subclasses of ferritins: the classical ferritins (Ftn), the heme-containing bacterioferritins (Bfr) and the DNA-binding proteins from starved cells (Dps). Ftn and Bfr are made of 24 subunits, whereas Dps are smaller with 12 subunits. Ftn is found in most kindoms, while Bfr and Dps are restricted to prokaryotes.


response to epinephrine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.


name: regulation of type B pancreatic cell proliferation

description: Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.


name: negative regulation of transcription regulatory region DNA binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.


description: Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.


macular retinal edema

description: Accumulation of intraretinal fluid and protein in the macula, which may result in swelling and decreased central vision.


name: positive regulation of endothelial cell differentiation

description: Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.


ephrin receptor activity

description: Combining with an ephrin receptor ligand to initiate a change in cell activity.


sequestering of triglyceride

description: The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.


name: aminoglycoside antibiotic metabolic process

description: The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.


pyrimidine nucleoside transport

description: The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cytolytic granule

description: A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.


quaternary ammonium group transport

description: The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.


hereditary angioedema

description: Hereditary angioedema (HAE) is a genetic disease characterized by the occurrence of transitory and recurrent subcutaneous and/or submucosal edemas resulting in swelling and/or abdominal pain.


name: positive regulation of meiotic cell cycle

description: Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.


name: intrinsic apoptotic signaling pathway in response to hypoxia

description: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered.


A 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-isopropylpiperazine in which positions 2 and 4 of the 1,3-dioxolane moiety have S and R configuration, respectively.


tonic smooth muscle contraction

description: A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction.


intestinal D-glucose absorption

description: Uptake of D-glucose into the blood by absorption from the small intestine.


RNA localization to Cajal body

description: A process in which an RNA is transported to, or maintained in, a Cajal body.


metanephric mesenchyme morphogenesis

description: The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros.


malabsorption syndrome

description: A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea.


name: positive regulation of cytokine production involved in immune response

description: Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.


Premature skin wrinkling

description: The presence of an increased degree of wrinkling (irregular folds and indentations) of the skin as compared with age-related norms.


maintenance of Golgi location

description: Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere.


U2-type prespliceosome

description: A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.


name: UDP-N-acetylglucosamine transmembrane transporter activity

description: Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.


Nasal ulcer

description: An open sore of the nasal mucosa.


name: negative regulation of cholesterol transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Visual hallucination

description: Visual perception in the absence of a visual stimulus.


angiotensin maturation

description: The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.


sulfisoxazole

A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.


cefmenoxime

A third-generation cephalosporin antibiotic, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position and a [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl group at the 3-position.


negative regulation of DNA repair

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.


acute pyelonephritis

description: Sudden onset pyelonephritis.


disaccharide metabolic process

description: The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units.


name: negative regulation of glucocorticoid receptor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.


name: corticotropin-releasing hormone receptor 1 binding

description: Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.


name: peptide antigen assembly with MHC protein complex

description: The binding of a peptide to the antigen binding groove of an MHC protein complex.


thalamus development

description: The process in which the thalamus changes over time, from its initial formation to its mature state.


name: regulation of hematopoietic stem cell migration

description: Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration.


response to dopamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.


name: positive regulation of miRNA catabolic process

description: Any process that activates or increases the frequency, rate or extent of miRNA catabolic process.


urinary tract smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.


steroid delta-isomerase activity

description: Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.


name: regulation of cardiac muscle cell contraction

description: Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.


name: substrate-dependent cerebral cortex tangential migration

description: The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions.


name: negative regulation of protein glycosylation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.


GABA receptor complex

description: A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor.


alcoholic hepatitis

description: Acute hepatitis resulting from ingestion of alcohol.


prostate glandular acinus morphogenesis

description: The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland.


natamycin

A macrolide antibiotic that has formula C33H47NO13, produced by several Streptomyces species including Streptomyces natalensis. It exhibits broad spectrum antifungal activity and used in eye drops, and as a food preservative, and also as a postharvest biofungicide for citrus and other fruit crops.


A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.


name: regulation of mitotic centrosome separation

description: Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis.


lung morphogenesis

description: The process in which the anatomical structures of the lung are generated and organized.


cloaca development

description: The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.


peroxisome fission

description: The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.


tic disorder

description: Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)


name: regulation of endodeoxyribonuclease activity

description: Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


aconitate hydratase activity

description: Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.


regulation of B cell chemotaxis

description: Any process that modulates the frequency, rate or extent of B cell chemotaxis.


Epidermal necrosis

description: Death of keratinocytes in the epidermis layer of the skin, which generally manifests as extensive exfoliation (separation of the epidermis from the underlying dermis).


name: deoxyribonucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.


L-amino acid transport

description: The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: embryonic retina morphogenesis in camera-type eye

description: The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.


nitrogen utilization

description: A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism.


cytomegalovirus infection

description: A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies.


lateral mesoderm development

description: The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.


knee joint

description: The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted].


name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification

description: The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization.


name: pyrimidine nucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.


glycogen binding

description: Binding to glycogen.


balanitis

description: An infectious or non-infectious inflammatory process that affects the glans penis. Symptoms include redness and pain of the glans penis and foreskin and discharge.


name: transmembrane receptor protein tyrosine kinase activator activity

description: Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.


nuclear mRNA surveillance

description: A process that identifies and degrades defective or aberrant mRNAs within the nucleus.


amlexanox

A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.


name: sodium ion export across plasma membrane

description: The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.


name: regulation of ubiquitin protein ligase activity

description: Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity.


regulation of eye pigmentation

description: Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism.


name: positive regulation of cell communication by chemical coupling

description: Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels.


dinucleotide phosphatase activity

description: Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides.


methylglyoxal metabolic process

description: The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.


H4 histone acetyltransferase complex

description: A protein complex which is capable of H4 histone acetyltransferase activity.


autoimmune hepatitis type 1

description: Autoimmune hepatitis characterized by the presence of antinuclear antibody (ANA) and antismooth-muscle antibody (ASMA).


cephalocele

description: A congenital neural tube closure defect resulting in the protrusion of the brain through a skull opening. When the protrusion includes the meninges, the term encephalomeningocele is used.


RNA-templated DNA biosynthetic process

description: A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.


sublingual gland

description: The small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland.


neuroendocrine cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.


name: positive regulation of type I interferon-mediated signaling pathway

description: Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway.


starch binding

description: Binding to starch.


name: regulation of smooth muscle cell differentiation

description: Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.


response to peptidoglycan

description: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.


positive regulation of penile erection

description: Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.


snRNA binding

description: Binding to a small nuclear RNA (snRNA).


glutathione binding

description: Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.


uridine phosphorylase activity

description: Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.


name: lymphoid progenitor cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.


embryonic hindlimb morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.


adjustment disorder

description: A category of psychiatric disorders which are characterized by emotional or behavioral symptoms that develop within 3 months of a stressor and do not persist for more than an additional 6 months after the stressor is no longer present.


U4atac snRNA binding

description: Binding to a U4atac small nuclear RNA (U4atac snRNA).


HLH domain binding

description: Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.


protein localization to lysosome

description: A process in which a protein is transported to, or maintained in, a location within a lysosome.


male mating behavior

description: The specific behavior of a male organism that is associated with reproduction.


isoprenaline

A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.


name: basic amino acid transmembrane transport

description: The directed movement of basic amino acids from one side of a membrane to the other.


urea metabolic process

description: The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.


cutaneous pseudolymphoma

description: A pseudolymphoma of the skin.


name: extracellular matrix structural constituent conferring tensile strength

description: A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.


name: pentose-phosphate shunt, non-oxidative branch

description: The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.


name: antigen processing and presentation of endogenous peptide antigen via MHC class I

description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.


regulation of hair cycle

description: Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.


name: establishment of endothelial blood-brain barrier

description: Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.


goiter

description: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.


name: type 3 metabotropic glutamate receptor binding

description: Binding to a type 3 metabotropic glutamate receptor.


diacylglycerol metabolic process

description: The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


name: negative regulation of lymphocyte chemotaxis

description: Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.


nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.


jaw skeleton

description: Subdivision of skeleton which includes upper and lower jaw skeletons.


2-oxoglutarate metabolic process

description: The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.


bile acid:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).


Paroxysmal atrial fibrillation

description: Episodes of atrial fibrillation that typically last for several hours up to one day and terminate spontaneously.


cellular response to histamine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.


name: negative regulation of establishment of protein localization to mitochondrion

description: Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion.


name: negative regulation of chronic inflammatory response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.


proline catabolic process

description: The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.


RNA import into mitochondrion

description: The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix.


cellular response to sterol depletion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


regulation of protein deubiquitination

description: Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein.


tamibarotene

A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.


description: The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol.


name: protein binding involved in heterotypic cell-cell adhesion

description: Binding to a protein or protein complex contributing to the adhesion of two different types of cells.


cellular response to lithium ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.


ciliary body

description: The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes.


endocardium development

description: The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


name: positive regulation of neurotransmitter secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.


Generalized-onset seizure

description: A generalized-onset seizure is a type of seizure originating at some point within, and rapidly engaging, bilaterally distributed networks. The networks may include cortical and subcortical structures but not necessarily the entire cortex.


name: catechol-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.


Ventricular Dysfunction

description: Impairment of the ventricle to either fill or eject adequately.


name: regulation of ventricular cardiac muscle cell action potential

description: Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


pyridoxal phosphate metabolic process

description: The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.


Cerebral venous thrombosis

description: Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow.


name: indole-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton.


replicative senescence

description: A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.


response to host

description: Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Protruding tongue

description: Tongue extending beyond the alveolar ridges or teeth at rest.


response to oleic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus.