potassium deficiency

description: A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing polyuria and decreased maximal urinary concentrating ability with secondary polydipsia. (Merck Manual, 16th ed)


supramolecular fiber organization

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.


vulvitis

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Inflammation of the vulva. It is characterized by pruritus and painful urination.


acute closed-angle glaucoma

description: Acute form of angle-closure glaucoma.


ovarian follicle atresia

description: A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed.


sex-chromosome dosage compensation

description: Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.


cefoperazone

A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.


name: positive regulation of acrosome reaction

description: Any process that activates or increases the frequency, rate or extent of the acrosome reaction.


name: negative regulation of inner ear receptor cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation.


Neck Edema

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Swelling due to an accumulation of excessive fluid in the neck.


name: negative regulation of immunoglobulin production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.


cellular lipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells.


precocious puberty

description: Unusually early sexual maturity.


name: pyrimidine nucleoside diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.


alpha-2C adrenergic receptor binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binding to an alpha-2C adrenergic receptor.


name: negative regulation of voltage-gated calcium channel activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity.


hypotrichosis

description: A congenital condition, usually due to genetic aberrations, that is characterized by a lack of hair growth on the head and/or body.


Renal Colic

description: Paroxysmal and severe flank pain radiating to the inguinal area. It is caused by the passage of a kidney stone through the ureter.


stem cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell.


description: Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.


norepinephrine metabolic process

description: The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.


ureteral obstruction

description: Blockage in any part of the ureter causing obstruction of urine flow from the kidney to the urinary bladder. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as hydronephrosis and obstructive nephropathy.


aldose reductase (NADPH) activity

description: Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.


esophageal varices

description: Abnormally dilated veins of the esophagus.


post-chaperonin tubulin folding pathway

description: Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors.


SUMO polymer binding

description: Binding to a polymer of the small ubiquitin-like protein SUMO.


name: positive regulation of synaptic transmission, GABAergic

description: Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).


metallochaperone activity

description: Binding to and delivering metal ions to a target protein.


name: adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor, and ending with the regulation of a downstream cellular process.


name: positive regulation of MHC class II biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.


GDP metabolic process

description: The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate.


name: positive regulation of synaptic plasticity

description: A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


name: clathrin-sculpted glutamate transport vesicle

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate.


dATP binding

description: Binding to dATP, deoxyadenosine triphosphate.


name: inositol hexakisphosphate 3-kinase activity

description: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate.


salt transmembrane transporter activity

description: Enables the transfer of salt from one side of a membrane to the other.


name: membrane depolarization during SA node cell action potential

description: The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


menaquinone catabolic process

description: The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.


atrophy of testis

description: Loss of testicular volume.


basal protein localization

description: Any process in which a protein is transported to, or maintained in, basal regions of the cell.


description: Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.


doxacurium

A mixture of the (1R,2S,1'S,2'R), (1R,2S,1'R,2'S) and (1S,2R,1'S,2'R) stereoisomers (a meso isomer and two enantiomers, respectively) of 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium], all of which are in a trans configuration at the 1 and 2 positions of the tetrahydroisoquinolinium rings. A competitive neuromuscular blocker, the chloride salt is used to provide muscle relaxation in general anaesthesia and to facilitate mechanical ventilation in patients in intensive care.


name: positive regulation of interleukin-17 production

description: Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


name: positive regulation of dendritic cell chemotaxis

description: Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.


mammary placode formation

description: The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper.


name: alanine transmembrane transporter activity

description: Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid.


scleroderma

description: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc).


complement component C3b binding

description: Binding to a C3b product of the complement cascade.


name: cerebellar cortex structural organization

description: The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


latamoxef

A broad-spectrum oxacephem antibiotic in which the oxazine ring is substituted with a tetrazolylthiomethyl group and the azetidinone ring carries methoxy and 2-carboxy-2-(4-hydroxyphenyl)acetamido substituents.


fucose binding

description: Binding to fucose, the pentose 6-deoxygalactose.


proteasome regulatory particle assembly

description: The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex.


Golgi reassembly

description: The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.


Bell's palsy

description: Partial or complete paralysis of the facial muscles of one side of a person's face. It is caused by damage to the seventh cranial nerve. It is usually temporary but it may recur.


hyoid bone

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A horseshoe shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. The hyoid bone provides attachment to the muscles of the floor of the mouth and the tongue above, the larynx below, and the epiglottis and pharynx behind. [WP,modified].


small cell lung carcinoma

description: Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure.


Decreased red blood cell count

description: An abnormal reduction below the normal number of red blood cells per volume in the circulation.


siderophore transport

description: The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


regulation of stem cell division

description: Any process that modulates the frequency, rate or extent of stem cell division.


late viral transcription

description: The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins.


phosphorylase kinase complex

description: An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.


Hyperfibrinogenemia

description: Increased concentration of fibrinogen in the blood.


interferon-beta production

description: The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


exocyst localization

description: Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.


DNA replication origin binding

description: Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.


pituitary tumor

description: A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland.


surfactant homeostasis

description: Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.


description: Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate.


astrocyte end-foot

description: Terminal process of astrocyte abutting non-neuronal surfaces in the brain.


description: Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.


name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

description: The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.


U6 snRNP

description: A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes.


(S)-limonene 7-monooxygenase activity

description: Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


retinal degeneration

description: Degeneration of the retina.


name: magnesium ion transmembrane transporter activity

description: Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.


name: regulation of resting membrane potential

description: Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.


name: positive regulation of protein kinase A signaling

description: Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.


Teething syndrome

description: An expected condition experienced by children during the emergence of deciduous teeth. Though a full set of 20 primary teeth takes more than two years to emerge, teething syndrome may be variably noted from the first paired eruption (usually at the sixth month) until the last. Characteristically, irritability, inflamed gingivae, drooling and chewing on solid objects may be seen several days prior to the eruption with rapid resolution. Typically, the lower central incisors appear first followed by the upper central incisors. Molars and canine teeth are the last to erupt.  Anecdotal associations with fever and diarrhea are misattributed.


oligosaccharyl transferase activity

description: Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.


histone H4R3 methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me.


tongue morphogenesis

description: The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.


JUN phosphorylation

description: The process of introducing a phosphate group into a JUN protein.


B cell homeostatic proliferation

description: The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.


fucosylation

description: The covalent attachment of a fucosyl group to an acceptor molecule.


pivmecillinam

A penicillanic acid ester that is the [(2,2-dimethylpropanoyl)oxy]methyl ester and prodrug of mecillinam.


name: regulation of translation, ncRNA-mediated

description: Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein.


Fractured rib

description: A partial or complete breakage of the rib.


Fetal acidosis

description: An abnormally high hydrogen ion concentration (umbilical arterial blood pH less than 7.00) in fetal blood or tissue.


prenylation

description: The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added.


Complications of Diabetes Mellitus

description: Organ or tissue damage due to diabetes mellitus. It includes heart disease and stroke, renal disease and renal failure, retinopathy, neuropathies, and erectile dysfunction.


neurotrophin TRKB receptor binding

description: Binding to a neurotrophin TRKB receptor.


name: positive regulation of histamine secretion by mast cell

description: Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell.


name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process

description: The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


name: negative regulation of oocyte maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.


oculomotor nerve morphogenesis

description: The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.


transepithelial transport

description: The directed movement of a substance from one side of an epithelium to the other.


name: negative regulation of bile acid biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


name: somatic recombination of T cell receptor gene segments

description: The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments.


name: regulation of cardioblast differentiation

description: Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.


name: endocytosis involved in viral entry into host cell

description: Any endocytosis that is involved in the uptake of a virus into a host cell.


transmitter-gated channel activity

description: Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.


embryonic cleavage

description: The first few specialized divisions of an activated animal egg.


microcephaly

description: A congenital or acquired developmental disorder in which the circumference of the head is smaller than normal for the person's age and sex.


Hypoplastic anemia

description: Anemia with varying degrees of erythrocytic hypoplasia without leukopenia or thrombocytopenia.


forebrain neuron fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.


name: response to follicle-stimulating hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.


protein adenylylation

description: The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid.


inamrinone

A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.


Benign neoplasm of female breast

description: A neoplasm that arises from the breast in females and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


carcinoma of esophagus

description: Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).


Orthopnea

description: A sensation of breathlessness in the recumbent position, relieved by sitting or standing.


name: regulation of collateral sprouting of intact axon in response to injury

description: Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon.


name: negative regulation of neurotrophin TRK receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.


CD8 receptor binding

description: Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.


glucagon receptor activity

description: Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


name: double-strand/single-strand DNA junction binding

description: Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA.


name: regulation of translational initiation by iron

description: Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron.


name: cell differentiation involved in salivary gland development

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland.


regulation of TORC1 signaling

description: Any process that modulates the frequency, rate or extent of TORC1 signaling.


name: negative regulation of Rho protein signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.


transition between slow and fast fiber

description: The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation.


integrin alpha2-beta1 complex

description: An integrin complex that comprises one alpha2 subunit and one beta1 subunit.


regulation of vitamin metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


name: modulation by host of viral exo-alpha-sialidase activity

description: The process in which a host organism effects a change in viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein.


labyrinthine layer morphogenesis

description: The process in which the labyrinthine layer of the placenta is generated and organized.


name: oxidoreductase activity, acting on metal ions, oxygen as acceptor

description: Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor.


'de novo' NAD biosynthetic process

description: The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.


name: negative regulation of neutrophil chemotaxis

description: Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


Seroma

description: A collection of serum in the body.


G protein-coupled receptor complex

description: A protein complex that contains G protein-coupled receptors.


inferior colliculus development

description: The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally.


tyrosine-tRNA ligase activity

description: Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+.


name: regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

description: Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.


regulation of myoblast proliferation

description: Any process that modulates the frequency, rate or extent of myoblast proliferation.


collecting duct development

description: The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder.


clathrin coat of coated pit

description: The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.


name: negative regulation of circadian sleep/wake cycle, REM sleep

description: Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.


facial muscle

description: A muscle innervated by a facial nerve.


cellular response to water stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.


AMPA glutamate receptor clustering

description: The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.


macula lutea

description: An oval area in the retina, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototopic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed).


name: susceptibility to natural killer cell mediated cytotoxicity

description: The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.


polyamine oxidase activity

description: Catalysis of the oxidative degradation or interconversion of polyamines.


Shuffling gait

description: A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground.


name: regulation of prostaglandin biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


name: regulation of lipoprotein metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


SNARE complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


lipid phosphatase activity

description: Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.


name: alcohol dehydrogenase (NAD+) activity, zinc-dependent

description: Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.


mammary gland involution

description: The tissue remodeling that removes differentiated mammary epithelia during weaning.


name: regulation of dendritic cell differentiation

description: Any process that modulates the frequency, rate or extent of dendritic cell differentiation.


description: The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.


chronic primary adrenal insufficiency

description: A chronic disorder of the adrenal cortex resulting in the inadequate production of glucocorticoid and mineralocorticoid hormones.


name: cellular response to high density lipoprotein particle stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus.


name: regulation of type II interferon-mediated signaling pathway

description: Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.


name: traversing start control point of mitotic cell cycle

description: A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.


name: negative regulation of hormone biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.


progesterone receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a progesterone binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


stereotypic movement disorder

description: Motor behavior that is repetitive, often seemingly driven, and nonfunctional. This behavior markedly interferes with normal activities or results in severe bodily self-injury. The behavior is not due to the direct physiological effects of a substance or a general medical condition. (dsm-iv, 1994)


primary amine oxidase activity

description: Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.


ripoptosome assembly

description: The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.


Left ventricular hypertrophy

description: Enlargement or increased size of the heart left ventricle.


name: atrial cardiac muscle cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ.


Cdc73/Paf1 complex

description: A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.


cell wall biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.


antifungal humoral response

description: An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.


exo-alpha-(2->3)-sialidase activity

description: Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates.


name: complement component C1q complex binding

description: Binding to a C1q complex, a component of the classical complement cascade.


name: regulation of forebrain neuron differentiation

description: Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.


interleukin-5 receptor binding

description: Binding to an interleukin-5 receptor.


subthalamus development

description: The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis.


corticotropin secretion

description: The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.


Pyrin domain binding

description: Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.


name: extracellular matrix constituent, lubricant activity

description: Functions as a lubricant for an extracellular matrix, such as a mucous membrane.


description: The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of catecholamine secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.


description: Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage.


mepyramine

An ethylenediamine derivative that is  ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.


regulation of hepatocyte proliferation

description: Any process that modulates the frequency, rate or extent of hepatocyte proliferation.


name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule.


integrin alpha9-beta1 complex

description: An integrin complex that comprises one alpha9 subunit and one beta1 subunit.


transformation of host cell by virus

description: A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication.


acid-amino acid ligase activity

description: Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.


left lung morphogenesis

description: The process in which anatomical structures of the left lung are generated and organized.


hypoparathyroidism

description: Hypoparathyroidism is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.


nail development

description: The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.


mRNA 3'-UTR AU-rich region binding

description: Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.


pICln-Sm protein complex

description: A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.


name: pentacyclic triterpenoid metabolic process

description: The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.


positive regulation of urine volume

description: Any process that increases the amount of urine excreted from the body over a unit of time.


name: regulation of respiratory burst involved in inflammatory response

description: Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


leukostasis

description: A disorder involving the aberrant infiltration and aggregation of leukocytes into the vasculature of the body. Leukostasis is typically detected in the brain and lungs of persons with leukemia. It requires substantial ablative modalities to both reduce the number of cells present and to ensure dispersion of the aggregates.


Increased Therapeutic Response

description: An increase in the desirable and beneficial effects resulting from a medical  treatment.


pulmonary valve formation

description: The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.


name: positive regulation of centriole replication

description: Any process that activates or increases the frequency, rate or extent of centriole replication.


Catheter related infection

description: An infection that arises secondary to catheter use.


iodide transport

description: The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

description: The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.


inositol metabolic process

description: The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.


name: negative regulation of mesodermal cell fate specification

description: Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.


name: negative regulation of plasminogen activation

description: Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.


opioid receptor binding

description: Binding to an opioid receptor.


spontaneous synaptic transmission

description: The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.


name: positive regulation of bone mineralization involved in bone maturation

description: Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation.


response to heparin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.


positive regulation of hypersensitivity

description: Any process that activates or increases the frequency, rate, or extent of hypersensitivity.


name: deoxyribonucleoside diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.


Lewy body core

description: The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments.


cellular response to cGMP

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.


deoxynucleoside kinase activity

description: Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.


name: positive regulation of cardiac muscle cell differentiation

description: Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.


sequestering of actin monomers

description: The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.


name: positive regulation of transmission of nerve impulse

description: Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.


name: meiotic sister chromatid cohesion, centromeric

description: The cell cycle process in which centromeres of sister chromatids are joined during meiosis.


cerebellar degeneration

description: Degeneration of the cerebellum. It may be an inherited condition, a paraneoplastic syndrome, or secondary to autoimmune disorders.


name: regulation of cell adhesion molecule production

description: Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.


Dissociation

description: Disruption or detachment of certain aspects of one's normal psychological functioning typically involves a disconnection or separation from thoughts, feelings, sensations, memories, or one's sense of identity or reality.


name: L-asparagine transmembrane transporter activity

description: Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid.


name: regulation of dopamine uptake involved in synaptic transmission

description: Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell.


congenital factor XI deficiency

description: Congenital factor XI deficiency is an inherited bleeding disorder characterized by reduced levels and activity of factor XI (FXI) resulting in moderate bleeding symptoms, usually occurring after trauma or surgery.


name: vasoactive intestinal polypeptide receptor activity

description: Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.


name: T follicular helper cell differentiation

description: The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell.


pro-B cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.


dysentery

description: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.


response to interleukin-15

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus.


name: intracellularly cAMP-activated cation channel activity

description: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.


3M complex

description: A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity.


cytidine deaminase activity

description: Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+.


polyarteritis nodosa

description: Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney.


name: positive regulation of cardiac muscle adaptation

description: Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.


description: Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP.


Fever Chills

description: Shivering secondary to a febrile process.


regulation of receptor clustering

description: Any process that modulates the frequency, rate or extent of receptor clustering.


smooth muscle hyperplasia

description: A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ.


name: positive regulation of B cell receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.


name: pyridine-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.


pointed-end actin filament capping

description: The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.


name: positive regulation of T cell cytokine production

description: Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.


neuron cell-cell adhesion

description: The attachment of a neuron to another cell via adhesion molecules.


name: negative regulation of transforming growth factor beta2 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2.


cementum mineralization

description: The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum.


name: fructose 1,6-bisphosphate 1-phosphatase activity

description: Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.


Metastatic malignant neoplasm to bone

description: Evidence of secondary malignant neoplasm of bone and bone marrow.


chronic urticaria

description: An urticaria that is characterized by the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week.


name: chloride:monoatomic cation symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).


polydactyly

description: A disease characterized by the presence of polydactyly, including syndromic and non-syndromic forms.


name: ribonucleoside monophosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.


DNA polymerase binding

description: Binding to a DNA polymerase.


name: Arp2/3 complex-mediated actin nucleation

description: The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.


DNA recombinase assembly

description: The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.


penetration of zona pellucida

description: The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm.


name: positive regulation of protein export from nucleus

description: Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.


venous blood vessel morphogenesis

description: The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.


name: regulation of skeletal muscle acetylcholine-gated channel clustering

description: Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.


name: positive regulation of glycogen (starch) synthase activity

description: Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity.


motor neuron migration

description: The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.


laminin-5 complex

description: A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains.


name: acidic amino acid transmembrane transporter activity

description: Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3.


name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.


name: negative regulation of endoplasmic reticulum unfolded protein response

description: Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.


extracellular matrix assembly

description: The aggregation, arrangement and bonding together of the extracellular matrix.


Chronic pain

description: Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.


name: postsynaptic density protein 95 clustering

description: The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins.


virion binding

description: Binding to a virion, either by binding to components of the capsid or the viral envelope.


name: regulation of circadian sleep/wake cycle, REM sleep

description: Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.


estrous cycle

description: A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.


cellular response to amine stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.


nuclear migration

description: The directed movement of the nucleus to a specific location within a cell.


ethanol binding

description: Binding to ethanol, CH(3)-CH(2)-OH.


Femur fracture

description: A break or crush injury of the thigh bone (femur).


lung induction

description: The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung.


name: deadenylation-independent decapping of nuclear-transcribed mRNA

description: Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening.


Fontanelle Bulging

description: Membranous areas between cranial bones in a newborn that appear elevated or full.


positive regulation of fibrinolysis

description: Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.


superior olivary nucleus maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


anterior spinal artery syndrome

description: Ischemia or infarction of the spinal cord in the distribution of the anterior spinal artery, which supplies the ventral two-thirds of the spinal cord. This condition is usually associated with atherosclerosis of the aorta and may result from dissection of an aortic aneurysm or rarely dissection of the anterior spinal artery. Clinical features include weakness and loss of pain and temperature sensation below the level of injury, with relative sparing of position and vibratory sensation. (From Adams et al., Principles of Neurology, 6th ed, pp1249-50)


name: high-density lipoprotein particle assembly

description: The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


name: positive regulation of protein autoubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein autoubiquitination.


name: posterior mesonephric tubule development

description: The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros.


Microscopic hematuria

description: Microscopic hematuria detected by dipstick or microscopic examination of the urine.


name: regulation of inositol phosphate biosynthetic process

description: Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


dermatan sulfate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


astral microtubule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.


name: regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

description: Any process that modulates the frequency, rate or extent of regulation of metanephric mesenchymal cell migration, by platelet-derived growth factor receptor-beta signaling pathway.


positive regulation of xenophagy

description: Any process that activates or increases the frequency, rate or extent of xenophagy.


Cytopenia

description: A laboratory test result indicating an abnormally low quantity of circulating blood cells.


description: The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cerebellar granular layer formation

description: The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.


ribonuclease inhibitor activity

description: Binds to and stops, prevents or reduces the activity of ribonuclease.


catecholamine secretion

description: The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.


name: ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

description: The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination.


regulation of cytolysis

description: Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm.


diencephalon morphogenesis

description: The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.


calcium import into the mitochondrion

description: A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.


UBC13-MMS2 complex

description: A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains. In Saccharomyces cerevisiae, the complex comprises Ubc13p and Mms2p; in human it comprises UBE2N and UBE2V1/UBE2V2; and in plants UBC35/UBC36 and UEV1A/UEV1B/UEV1C/UEV1D-4.


platelet alpha granule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets.


name: inhibition of cysteine-type endopeptidase activity involved in apoptotic process

description: Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process.


Abnormal leukocyte morphology

description: An abnormality of leukocytes.


peptidyl-proline 4-dioxygenase activity

description: Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.


name: positive regulation of protein lipidation

description: Any process that activates or increases the frequency, rate or extent of protein lipidation.


common hepatic duct

description: Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP].


torsion dystonia

description: Sustained involuntary muscle contractions that produce twisting and repetitive movements of the body.


name: positive regulation of follicle-stimulating hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone.


carbohydrate kinase activity

description: Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule.


name: negative regulation of somatic stem cell population maintenance

description: Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance.


name: ossification involved in bone remodeling

description: The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.


name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

description: The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.


name: nuclear fragmentation involved in apoptotic nuclear change

description: The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.


name: forebrain anterior/posterior pattern specification

description: The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.


name: negative regulation of appetite by leptin-mediated signaling pathway

description: The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.


gingival disorder

description: A disease involving the gingiva.


name: positive regulation of heparan sulfate proteoglycan biosynthetic process

description: Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues.


Decreased serum creatinine

description: An abnormally reduced amount of creatinine in the blood.


name: negative regulation of glucokinase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


name: positive regulation of glucocorticoid secretion

description: Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion.


name: negative regulation of cell proliferation involved in kidney development

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development.


D1 dopamine receptor binding

description: Binding to a D1 dopamine receptor.


name: alcohol transmembrane transporter activity

description: Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group.


Prinzmetal angina

description: A syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel walls rather than directly by atherosclerosis (buildup of fatty plaque and hardening of the arteries). For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma.


name: isolated growth hormone deficiency type IA

description: An isolated growth hormone deficiency characterized by autosomal recessive inheritance of severe dwarfism with onset by 6 months of age and variable development of antibodies to growth hormone following exogenous supplementation that has material basis in null mutations in the GH1 gene on chromosome 17q23.3.


protein nitrosylation

description: The covalent addition of a nitric oxide group to an amino acid within a protein.


response to phenylpropanoid

description: Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin.


spongiotrophoblast differentiation

description: The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell.


short-term memory

description: The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.


renal sodium ion absorption

description: A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


name: short-chain fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.


name: regulation of vascular associated smooth muscle contraction

description: Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.


name: insulin secretion involved in cellular response to glucose stimulus

description: The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.


elastin metabolic process

description: The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue.


name: microtubule nucleation by microtubule organizing center

description: The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.


skeletal myofibril assembly

description: The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.


name: paraxial mesodermal cell fate commitment

description: The process in which a cell becomes committed to become a paraxial mesoderm cell.


Uric acid crystalluria

description: The presence of uric acid crystals in the urine.


negative regulation of feeding behavior

description: Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.


name: positive regulation of skeletal muscle tissue regeneration

description: Any process that activates or increase the rate of skeletal muscle regeneration.


name: regulation of antigen processing and presentation of peptide antigen via MHC class I

description: Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.


cytidine to uridine editing

description: The conversion of a cytosine residue to uridine in an RNA molecule by deamination.


name: insulin-like growth factor ternary complex

description: A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development.


dynactin complex

description: A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.


name: optic cup morphogenesis involved in camera-type eye development

description: The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.


name: directional guidance of interneurons involved in migration from the subpallium to the cortex

description: The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex.


name: positive regulation of muscle hypertrophy

description: Any process that activates or increases the frequency, rate or extent of muscle hypertrophy.


type I interferon production

description: The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


muscle alpha-actinin binding

description: Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.


name: negative regulation of apoptotic process involved in development

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development.


name: regulation of guanylate cyclase activity

description: Any process that modulates the frequency, rate or extent of guanylate cyclase activity.


description: Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.


name: negative regulation of epithelial cell proliferation involved in prostate gland development

description: Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time.


respiratory chain complex IV

description: A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).


description: Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.


dystocia

description: Slow or difficult obstetric labor or childbirth.


regulation of neutrophil degranulation

description: Any process that modulates the frequency, rate, or extent of neutrophil degranulation.


Umbilical hernia

description: Protrusion of abdominal contents through a defect in the abdominal wall musculature around the umbilicus. Skin and subcutaneous tissue overlie the defect.


histidine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).


alditol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group.


name: fructose 1,6-bisphosphate metabolic process

description: The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.


I-kappaB/NF-kappaB complex

description: A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm.


name: meiotic telomere tethering at nuclear periphery

description: The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle.


name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

description: Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.


regulation of T cell costimulation

description: Any process that modulates the frequency, rate or extent of T cell costimulation.


name: positive regulation of circadian sleep/wake cycle, REM sleep

description: Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.


seborrheic infantile dermatitis

description: Excessive shedding of dry scaly material from the scalp in humans.


IgE binding

description: Binding to an immunoglobulin of the IgE isotype.


chromatin silencing complex

description: Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.


name: RNA polymerase I core promoter sequence-specific DNA binding

description: Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.


loop of Henle development

description: The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule.


glycoside catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.


description: Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.


name: corticotropin-releasing hormone receptor 2 binding

description: Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery.


name: negative regulation of transcription elongation by RNA polymerase II

description: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


ammonia-lyase activity

description: Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.


name: DNA polymerase processivity factor activity

description: An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.


name: negative regulation of membrane potential

description: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


collagen type XI trimer

description: A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils.


name: regulation of sequestering of triglyceride

description: Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.


name: nuclear polyadenylation-dependent ncRNA catabolic process

description: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA.


peptidyl-arginine N-methylation

description: The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein.


glycocalyx

description: A carbohydrate rich layer at the outermost periphery of a cell.


ceramide kinase activity

description: Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate.


protein K69-linked ufmylation

description: A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.


name: histone H4K16 acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.


induction of programmed cell death

description: A process which directly activates any of the steps required for programmed cell death.


N-terminal peptidyl-lysine acetylation

description: The acetylation of the N-terminal lysine of proteins.


polynucleotide 3' dephosphorylation

description: The process of removing one or more phosphate groups from the 3' end of a polynucleotide.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.


phosphatidylethanolamine binding

description: Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.


thick ascending limb development

description: The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule.


fatty acyl-CoA hydrolase activity

description: Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.


name: halogenated hydrocarbon metabolic process

description: The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine.


calcineurin complex

description: A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.


UDP-glucuronate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.


name: negative regulation of delayed rectifier potassium channel activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity.


Drug toxicity

description: An adverse effect of a drug used therapeutically or diagnostically.


mastoiditis

description: Inflammation of the mucosal lining of the mastoid antrum and mastoid air cell system of the mastoid process.


macrolide binding

description: Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species.


menaquinone metabolic process

description: The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.


name: nuclear receptor-mediated glucocorticoid signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a glucocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: negative regulation of translation in response to stress

description: Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.


oxoglutarate dehydrogenase complex

description: A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.


name: negative regulation of toll-like receptor 4 signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


name: NAD-dependent histone deacetylase activity

description: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.


N-terminal peptidyl-serine acetylation

description: The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine.


single-stranded DNA helicase activity

description: Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.


response to iron(III) ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus.


deoxyribonuclease II activity

description: Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products.


actin modification

description: Covalent modification of an actin molecule.


cerebral arteritis

description: An inflammatory disease involving a pathogenic inflammatory response in the cerebral artery.


angiotensin receptor binding

description: Binding to an angiotensin receptor.


name: positive regulation of triglyceride catabolic process

description: Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.


anencephaly 1

description: Anencephaly is a neural tube defect. This malformation is characterized by the total or partial absence of the cranial vault and the covering skin, the brain being missing or reduced to a small mass. Most cases are stillborn, although some infants have been reported to survive for a few hours or even a few days.


alditol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group.


immature B cell differentiation

description: The process in which a precursor cell type acquires the specialized features of an immature B cell.


name: regulation of vascular associated smooth muscle cell proliferation

description: Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.


name: regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

description: Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis.


pelvic inflammatory disease

description: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.


name: type III transforming growth factor beta receptor binding

description: Binding to a type III transforming growth factor beta receptor.


paranasal sinus

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity.


Abnormal vertebral morphology

description: An abnormality of one or more of the vertebrae.


Immunologic Tests

category: biolink:Procedure biolink:ActivityAndBehavior biolink:NamedThing biolink:Occurrent biolink:PhysicalEssenceOrOccurrent


HFE-transferrin receptor complex

description: A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.


carotene metabolic process

description: The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids.


neutrophil apoptotic process

description: Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.


name: regulation of skeletal muscle tissue growth

description: Any process that modulates the frequency, rate or extent of skeletal muscle growth.


negative regulation of lipid storage

description: Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.


name: positive regulation of dendritic cell antigen processing and presentation

description: Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.


name: negative regulation of secondary metabolite biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process.


name: negative regulation of dendritic cell cytokine production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.


name: polyadenylation-dependent mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.


name: negative regulation of reactive oxygen species biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.


name: negative regulation of myeloid dendritic cell activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.


sphingolipid transporter activity

description: Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


name: bone mineralization involved in bone maturation

description: The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state.


myotome development

description: The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.


queuosine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.


guanylate cyclase regulator activity

description: Modulates the activity of guanylate cyclase.


lysine-acetylated histone binding

description: Binding to a histone in which a lysine residue has been modified by acetylation.


coronary thrombosis

description: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.