Male Reproductive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the male reproductive system.


name: Injury of esophagus without open wound into thoracic cavity

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Trauma to the esophagus without indication of associated damage to the skin and other internal and external tissues.


Hemorrhage of prostate

description: Bleeding originating from the prostate gland.


Fallopian tube perforation

description: A rupture of the fallopian tube wall due to tubal pregnancy, or other traumatic or pathologic processes.


Postpartum Complication

description: Any adverse event that arises in the six week period immediately following the delivery of a fetus.


Fetal virilism

description: Inappropriate secondary sex characteristics in the neonate usually due to in utero androgen exposure.


Gastric Obstruction

description: Blockage of the normal flow of the contents in the stomach.


Subclinical Seizure

description: A seizure with no apparent symptoms.


Pathologic Laughter

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A condition defined by relatively uncontrollable episodes of laughing.


Injury of larynx

description: Trauma to the larynx.


Injury of anus

description: Trauma to the anus.


Syphilitic aneurysm of aorta

description: Aneurysm of the aorta secondary to syphilis.


Early Pregnancy Loss

description: Pregnancy loss before 10th week of gestation with documentation of a confirmed pregnancy.


Endocrine System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the endocrine system.


Laceration of the Globe

description: Full-thickness wound of the eyewall (cornea and/or sclera) caused by a sharp object.


Baseline Fetal Heart Rate

description: The number of fetal cardiac beats per minute, considered as the reference value against which measurements in the future can be made.


Foreign body in stomach

description: Extraneous material located within the stomach.


Arteriovenous fistula aneurysm

description: A bulge in a weakened vessel wall segment of an arteriovenous fistula.


Coma Greater than 24 Hours

description: An indication that coma has lasted more than 24 hours.


name: Proximal Left Anterior Descending Coronary Artery Stenosis

description: A narrowing of the proximal portion of the left main coronary artery, usually considered significant if the stenosis is 70% or greater.


Fine corneal edema

description: Corneal edema of inflammatory origin associated with contact lens wear and morphologically characterized by presence of epithelial microcysts. Microcysts are small (typically 10-50 microns in diameter), clear, irregularly shaped high refractive inclusions that form in the basal layers of the epithelium and move towards the anterior surface of the cornea, surrounding epithelial haze. The cause of microcytic edema is related to the physical presence of contact lenses and possibly a mechanical effect of lens wear.


Leukoderma

description: Localized loss of skin pigmentation, often in patches.


Penetrating open globe injury

description: Full thickness wound of the eyewall (cornea and/or sclera) caused by the entry of a sharp object into the eye. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Achalasia

description: Failure of the smooth muscle fibers of the gastrointestinal tract to relax at any one point of junction of one part with another.


Cartilage injury

description: Trauma to cartilage.


Macropsia

description: An alteration in visual perception that causes objects to appear larger than their actual size.


Erythema of the Oropharyngeal Mucosa

description: Erythema of the mucus membranes lining the part of the pharynx located between the soft palate and the upper portion of the epiglottis.


Tracheostomy Site Bleeding

description: Bleeding from the tracheostomy site.


left main coronary artery stenosis

description: Percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery.


Eye muscle weakness

description: A reduction in the strength of the eye muscles.


Urinary Tract Stenosis

description: An intrinsic narrowing of a lumen of the urinary tract.


Sensory Change

description: An alteration in the perceptual senses an individual.


Ileal Obstruction

description: Blockage of the normal flow of the small intestinal contents in the ileum.


name: Ventricular Tachycardia/Ventricular Fibrillation Arrest

description: A cardiac arrest attributed to ventricular tachycardia or ventricular fibrillation.


name: AV Block Second Degree Mobitz Type I by ECG Finding

description: An electrocardiographic finding of intermittent failure of atrial electrical impulse conduction to the ventricles, characterized by a progressively lengthening PR interval prior to the block of an atrial impulse. (CDISC)


Spinal Injuries

description: Damage to the spine that results in impaired function.


Familial Male Precocious Puberty

description: Early development of isosexual secondary characteristics in boys, due to autosomal dominant mutations in the LHCGR gene.


Pigmentary Change in Skin

description: Abnormal skin pigmentation.


Injury to Superior Vena Cava

description: Damage to the superior vena cava from traumatic or pathologic processes.


Antepartum Uterine Rupture

description: An acute symptomatic tearing of the uterine wall prior to the onset of labor.


Carotid Artery Injuries

description: Damage to the carotid artery. Causes include blunt injuries (e.g., motor vehicle accidents and sports-related injuries) and penetrating traumas (e.g., gunshot and knife injuries).


Dissecting Abdominal Aortic Aneurysm

description: A dissecting aneurysm in the portion of the descending aortic wall that is within the abdomen.


Chronic peritoneal effusion (disorder)

description: Persistent or recurring accumulation of fluid in the peritoneal cavity.


Vaginal Discharge

description: Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer.


Erb-Duchenne Paralysis

description: Weakness or paralysis of muscles in the arm due to damage in the upper brachial plexus.


Spontaneous Intestinal Perforation

description: A focal intestinal perforation without a definite cause, commonly located in the terminal ileum, lacking the transmural inflammation and/or pneumatosis typically seen in necrotizing enterocolitis.


Injury of kidney

description: Trauma to the kidney.


Cardioinhibitory Syncope

description: A condition in which neurally-mediated syncope occurs in which the blood pressure falls and heart rate falls. (ACC/AHA)


Zenker Diverticulum

description: A diverticulum of the posterior pharyngeal wall opening, which is located just posterior the cricoid cartilage, between the inferior pharyngeal constrictor and the cricopharyngeus muscles.


Visual Change

description: An alteration in the visual system of an individual.


Foot Or Leg Hypoesthesia

description: Consisting of abnormally decreased sensitivity, particularly to touch in the foot or leg.


Hormone Resistance

description: A finding indicating decreased tissue sensitivity to a hormone.


Finger Injuries

description: Trauma to one of the digits on the hand.


Myxedema coma

description: A life-threatening condition characterized by altered mental status and defective thermoregulation. It is seen in individuals with severe, decompensated hypothyroidism.


Gastrointestinal Adhesion

description: A fibrous connection of tissue that joins together normally separate gastrointestinal regions.


Urostomy perforation

description: A perforation in the anatomic parts which are used in the construction of a urostomy.


Heart Block by ECG Finding

description: An electrocardiographic finding of blocked cardiac electrical impulses along the fibers normally responsible for impulse conduction.


Unilateral Numbness

description: A loss of the sensation of feeling on one side of the body.


Perforating open globe injury

description: Open globe injury with both entrance and exit wounds in the eyewall (cornea and/or sclera) caused by the same object.


Cushing Triad

description: A group of signs that often occurs in response to increased intracranial pressure: hypertension, bradycardia, and irregular breathing.


Flasher

description: The perception of sudden or brief bursts (flashes) of light.


Hemorrhage of digestive system

description: Bleeding originating from any part of the digestive system.


Syncope due to Migraine

description: A condition in which syncope occurs associated with the occurrence of cerebral vasospasm. (ACC/AHA)


Caries, Region Unknown

description: Tooth decay of an unspecified location.


name: Cardiogenic Shock Stage B Related to COVID-19

description: Clinical signs of shock or compensated shock in a patient with probable or confirmed acute COVID-19 wherein they may be volume overloaded, tachycardic, and/or hypotensive but no evidence of hypoperfusion on physical exam or laboratory studies.


Malignant ascites

description: Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic malignant neoplasms in the peritoneum.


Vasoconstriction

description: Vasoconstriction involves narrowing of a blood vessel lumen due to smooth muscle contraction in the vessel wall and leads to decreased blood flow.


Connective and Soft Tissue Injury

description: Damage inflicted on the soft tissues and their supporting structures as the direct or indirect result of an external force, with or without disruption of structural continuity.


Motor Manifestations

description: The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent.


Ureterovesical Obstruction

description: Blockage of the opening between the ureter and the bladder resulting in the reduction or prevention of the urine flow from the ureter to the bladder.


name: Supraventricular Arrhythmia by ECG Finding

description: An electrocardiographic finding of an arrhythmia originating in the atrium, AV node or AV junction.


Electrocardiographic Finding

description: Graphic representation and categorization of the electrical vectors produced by the depolarization and repolarization of myocardial tissue.


Unspecified antepartum hypertension

description: High blood pressure in the period of time preceding labor and delivery.


Primary Cough Headache

description: Headache triggered by coughing or straining in the absence of an intracranial disorder.


Seizure Related to COVID-19

description: Seizure in a patient with probable or confirmed acute COVID-19.


Digestive System Signs and Symptoms

description: Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion.


Intestinal Stoma Site Hemorrhage

description: A finding of blood leakage from the intestinal stoma.


name: Cardiogenic Shock Stage C Related to COVID-19

description: Clinical signs of cardiogenic shock with clinical evidence of hypotension and hypoperfusion (cold and wet) on physical examination that requires intervention (inotrope, pressor or mechanical support, including extracorporeal membrane oxygenation (ECMO)) beyond volume resuscitation to restore normal perfusion in a patient with probable or confirmed acute COVID-19.  Invasive hemodynamics may demonstrate the classic depressed cardiac index associated with cardiogenic shock.


Conjunctival Ecchymosis

description: Bleeding between the conjunctiva and episclera in the absence of discharge or inflammation.


name: Paroxysmal Atrial Fibrillation by ECG Finding

description: An electrocardiographic tracing demonstrating intermittent atrial fibrillation in the presence of sinus rhythm, junctional rhythm, or an atrial paced rhythm.


Jejunal hemorrhage

description: Bleeding originating from the jejunal wall.


Recurrent Large Pleural Effusion

description: The reemergence of a large pleural effusion after a period of remission.


Uncomplicated hypertension

description: A condition of high blood pressure without resulting clinical disorders.


name: Cervical Spine Joint Range of Motion Decreased

description: Decreased flexibility of a cervical spine joint.


Phosphene Visualization

description: An objective visual sensation that appears with the eyes closed and in the absence of visual light.


Testicular Cyst

description: A cystic lesion located in the testes.


Valvular stenosis

description: Narrowing of the opening of one or more of the four valves of the heart.


Inferior vena cava stenosis

description: Abnormal narrowing of the lumen of the inferior vena cava.


Coronary artery perforation

description: A dissection that extends through the full thickness of the coronary arterial wall. (ACC)


Page kidney

description: Hypertension resulting from activation of the renin-angiotensin system in response to prolonged compression of the renal parenchyma and blood vessels.


name: Decreased Visual Acuity with Current Correction

description: Diminished clarity of vision with current correction (glasses and/or contacts).


name: Congenital obstruction of ureteropelvic junction

description: Complete or partial blockage of the ureter at the point where it enters the kidney that is present at birth.


Phantogeusia

description: A lingering, usually unpleasant, taste without the associated stimulus.


Breastfeeding Jaundice

description: Yellow coloring of skin, mucous membranes and eyes in an otherwise healthy breast-fed newborn due to insufficient intake of maternally-expressed milk. It commonly appears four to seven days after birth.


Carcinomatous ascites

description: Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic carcinoma in the peritoneum.


Atrial Flutter by ECG Finding

description: An electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth like pattern between the QRS complexes. (CDISC)


Neck sprain

description: Stretching or tearing of ligaments in the neck.


Laceration of liver

description: A cut or tear in the liver.


name: Incomplete Left Bundle Branch Block by ECG Finding

description: An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifest as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration less than 120 ms. (CDISC)


name: Left Main Coronary Artery Stenosis, Percentage

description: The percentage of narrowing of the left main coronary artery.


Extraocular Muscle Paresis

description: A slight or incomplete paralysis of an extraocular muscle.


Open globe injury

description: A full thickness wound of the eyewall (sclera and cornea). (Birmingham Eye Trauma Terminology System (BETTS))


Primary Exertional Headache

description: Headache triggered by exercise.


Pregnancy Related Skin Change

description: Alterations in the skin's appearance during pregnancy due to hormonal level changes.


Atrial Premature Complex by ECG Finding

description: An electrocardiographic finding of an ectopic impulse originating in the atria and not specifically in the sinus node. The P wave morphology of these complexes is often different from a sinus P wave and the RR intervals preceding these complexes is also shorter than those of the regular beats. (CDISC)


Active Caries

description: Tooth decay that is increasing in size or scope.


Hemorrhagic ascites

description: Accumulation of hemorrhagic fluid in the peritoneal cavity.


Late Fetal Death

description: Death of a fetus at 16 weeks, 0 days to 19 weeks, 6 days of gestation.


Hemorrhage of spermatic cord

description: Bleeding originating from the spermatic cord.


Chemical burns of eye

description: Injury to the eye secondary to a chemical substance.


name: Sternocleidomastoid Injury Related to Birth

description: Disruption of the sternocleidomastoid muscle incurred during delivery.


Vas deferens obstruction

description: Blockage of the normal flow of the sperm in the vas deferens.


Bowel Burn

description: A thermal, chemical or radiation injury to the bowels.


name: injury of rectum with open wound into cavity

description: Trauma to the rectum associated with a break in the tissue that extends into the rectum.


Brachial Plexus Palsy

description: An injury that results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm. In the majority of cases there is spontaneous recovery.


Bone injury

description: Trauma to bone.


Pleural Effusion, Malignant

description: A collection of fluid in the pleural cavity resulting from malignant disease. Malignant pleural effusions often contain free-floating malignant cells.


Endoleak

description: Persistent blood flow/pressure in the aneurysm sac following an endovascular aneurysm repair (EVAR) procedure.


Bradycardia Arrest

description: Cardiac arrest that was a result of bradycardia.


Connective and Soft Tissue Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the connective and soft tissue.


Fetal Hypoxemia

description: Abnormally low arterial blood oxygen concentration in a fetus.


Muscular Tic

description: An involuntary, compulsive, repetitive stereotyped movement, usually of the face or shoulders.


Unspecified renovascular hypertension

description: High blood pressure caused by renal artery stenosis.


Nervous System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the nervous system.


Early Fetal Death

description: Death of a fetus at 10 weeks, 0 days to 15 weeks, 6 days of gestation.


Neurogenic Orthostatic Hypotension

description: Orthostatic hypotension due to autonomic dysfunction. Primary neurogenic orthostatic hypotension (nOH) may be associated with disorders such as Parkinson disease (PD) and multiple system atrophy (MSA) whereas secondary nOH may be seen in peripheral neuropathies.


Delayed Postpartum Hemorrhage

description: Excessive blood loss between 24 hours after delivery through four weeks that requires intervention.


Poor Sucking Reflex

description: Uncoordinated or ineffective drawing of saliva or breast milk by a newborn infant.


Abnormal Sensation of Face and Limbs

description: Sensations of the face and limbs that are not considered normal.


Tongue biting

description: Clamping of the teeth on the tongue, as can accompany a seizure. (ACC/AHA)


Injury of ear

description: Trauma to the ear.


Chronic Maternal Hypertension

description: Hypertension that predates pregnancy.


Junctional premature complex (disorder)

description: An electrocardiographic finding of an ectopic impulse originating in the AV junction presenting as a QRS complex of supraventricular origin which is not preceded by a P wave. (CDISC)


name: Immunodeficiency due to Quantitative Defects

description: An indication that an immunodeficiency disorder is caused by a partial or complete loss of one or more of the hematopoietic cell lineages that are involved in host defense.


name: Injury of duodenum with open wound into abdominal cavity

description: Trauma to the duodenum associated with a break in the tissue that extends into the abdominal cavity.


Drug-induced Syncope

description: A condition in which syncope occurs due to the ingestion or administration of a chemical substance. (ACC/AHA)


Hand Injuries

description: Trauma to the hand.


Bursa injury

description: Trauma to a bursa.


Abnormal Gait and Coordination

description: Gait and coordination movements that are not considered normal.


Endobronchial Obstruction

description: Partial or complete blockage of the bronchial lumen by a pathological process that occurs within the bronchus.


Mottling

description: Irregularly shaped, patchy discolorations in the skin.


Third Trimester Antepartum Hemorrhage

description: Excessive blood loss within the third trimester but prior to onset of labor.


Iris pigment epithelial cyst

description: A cystic lesion arising from the iris pigment epithelium at the posterior iris surface. (WHO 2018)


Abortion complete

description: Expulsion of all the products of conception following spontaneous, medical or operative pregnancy termination.


Induced Abortion Finding

description: Abortion brought on intentionally.


Corneal burn

description: Chemical or radiant injury to the cornea.


Right Ventricular Dysfunction

description: Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall.


Arteriovenous graft aneurysm

description: A bulge in a weakened wall segment of an arteriovenous graft.


Spermatic cord obstruction

description: Blockage of the normal flow of the contents of the spermatic cord.


Atrial Fibrillation by ECG Finding

description: An electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregularly irregular ventricular response. (CDISC)


name: Intra-Atrial Conduction Delay by ECG Finding

description: An electrocardiographic finding of a delay in impulse propagation through the atria. This is characterized by broad P waves which are often biphasic in V1. (CDISC)


Hematosalpinx

description: The presence of blood in a fallopian tube.


name: Associated Pulmonary Arterial Hypertension

description: Pulmonary hypertension that results from another disorder (e.g., connective tissue disorder).


ST Segment Abnormality by ECG Finding

description: An electrocardiographic finding of ST segment elevation or depression.


Ovarian Hyperandrogenism

description: Increased production of androgens by the ovaries.


Exit Block by ECG Finding

description: An electrocardiographic finding in which impaired conduction or automaticity within the sinus node results in the failure of impulse transmission from the sinoatrial node. This is manifested as dropped P waves during sinus rhythm. (CDISC)


Intraoperative Venous Injury

description: Damage to a vein during a surgical procedure.


Urinary Tract Diverticulum

description: A pouch or sac-like protrusion in the urinary tract.


Hemorrhage of testis

description: Bleeding originating from the testis.


Resuscitated Cardiac Arrest Event

description: Cardiac arrest that is reversed, usually by CPR and/or defibrillation or cardioversion, or cardiac pacing.


Disturbance of Skin Sensation

description: Disruption of the normal functioning of the sensory nerves in the skin.


Early Stillbirth

description: Delivery of a dead fetus greater than 22 weeks but less than 28 weeks gestational age, and/or whose birth weight is greater than 500 grams but less than 1,000 grams.


Injury of gallbladder

description: Trauma to the gallbladder.


Intraoperative Ocular Injury

description: Damage to the eye during a surgical procedure.


Heart Sound

description: Auditory vibrations of varying intensity (loudness), frequency (pitch), quality, and duration noted during auscultation of the thorax as part of the examination of the cardiovascular system. (ACC/AHA)


Neonatal melena

description: Abnormally dark tarry feces containing blood, usually due to gastrointestinal bleeding or swallowed maternal blood in neonates.


Opioid-Induced Constipation

description: Constipation that results from, or follows, treatment with an opioid or opioid-containing medication.


Closed injury of kidney

description: Trauma to the kidney without indication of associated damage to the skin and other internal and external tissues.


Paroxysmal atrioventricular block

description: An electrocardiographic finding of the sudden onset of transient AV block, which is often associated with preexisting conduction disorders. (CDISC)


Arm Or Hand Hypoesthesia

description: Consisting of abnormally decreased sensitivity, particularly to touch in the arm or hand.


Delayed Epiphyseal Fusion

description: Abnormally late fusion of the bone growth plate.


Surgical Shock

description: Hypoperfusion of body tissues occurring during or after a surgical procedure, and resulting in cellular injury and vital organ dysfunction.


Cardiac perforation

description: The presence of an acquired hole in the heart. Cardiac perforation may or may not be symptomatic and may or may not be self sealing. (ACC)


Female Reproductive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the female reproductive system.


Ambulation or Postural Difficulties

description: Any persistent problem with walking, gait or maintaining posture (sitting, standing).


name: Central Nervous System Signs and Symptoms

description: Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges.


Intraoperative Digestive System Injury

description: Damage to any part of the digestive system during a surgical procedure.


Syncope with Exertion

description: A condition in which syncope occurs either during or after physical activity. (ACC/AHA)


Premature Epiphyseal Fusion

description: Abnormally early fusion of the bone growth plate.


Vasodepressor Syncope

description: A condition in which neurally-mediated syncope occurs in which the blood pressure falls and the heart rate increases. (ACC/AHA)


name: Cardiac Arrest Prior to Percutaneous Coronary Intervention

description: Cardiac arrest which occurs before a percutaneous coronary intervention can take place. (ACC)


Toxic Erythema of Chemotherapy

description: Painful red or purple patches, edematous plaques or blisters on the hands, feet, extremities or intertriginous regions; the onset can occur days to months after receiving chemotherapy.


Neonatal Vaginal Discharge

description: Secretions which may be thin or tenacious, mucoid or glairy, grayish or milky, occasionally blood tinged, that originate in the vagina and are a consequence of the residual influence of maternal estrogen.


Vasovagal Reaction

description: Sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the activity of the vagus nerve. It may be triggered by emotions of fear or pain or gastrointestinal upset and may be relieved by lying down while keeping the legs elevated.


Illegal Abortion

description: Unlawfully induced expulsion of all products of conception.


Postcoital bleeding

description: Non-menstrual bleeding that occurs during or after sexual intercourse.


Hemorrhage of vas deferens

description: Bleeding originating from the vas deferens.


Injury of musculoskeletal system

description: Damage to the muscles, bones and their supportive structural attachments.


Immediate Postpartum Hemorrhage

description: Cumulative blood loss of greater than or equal to 1000 ML or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours following the birth process (includes intrapartum loss). (reVITALize)


Infectious Hidradenitis

description: Hidradenitis that is caused by an infectious agent, usually a bacterium.


Skin Type

description: A distinctive characteristic of the skin marked by the amount of sebum secreted by sebaceous glands.


Binocular Diplopia

description: Perception of two images secondary to misalignment of the eyes.


Gum injury

description: Trauma to the gingiva


name: Atrioventricular Reentrant Tachycardia by ECG Finding

description: An electrocardiographic finding of a regular supraventricular tachycardia which utilizes an atrioventricular bypass tract as its retrograde limb (orthodromic tachycardia) or as its antegrade limb (antidromic tachycardia). QRS complexes during sinus rhythm may show preexcitation. During orthodromic tachycardia the preexcitation is not present and a retrograde P wave may appear after the QRS complex. During antidromic tachycardia the QRS complex is preexcited. (CDISC)


Labial Fusion

description: Usually found in girls between 6 months and 6 years of age, this condition occurs wherein the labia grow together instead of as 2 separate folds, thereby blocking the opening of the vagina. It is caused by conditions such as repeated diaper rash, urine and stool infections, and sexual abuse. The condition often spontaneously corrects or responds to the application of estrogen cream.


Fecal Urgency

description: A continual or recurrent inclination to evacuate the bowels.


name: Infertility Related to Medical Condition

description: Infertility that is associated with a medical condition.


Rathke Cleft Cysts

description: Rathke's pouch cysts are rarely symptomatic in the first two decades of life though they may produce symptoms in the third and fourth decades of life.  When the cysts do present in the first decades of life, the symptoms are generally associated with diabetes insipidus or other conditions related to hypopituitarism.


name: COVID-19-Associated Acute Digestive System Injury

description: Acute digestive system injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Hypertension Secondary To Endocrine Disorders

description: Evidence of hypertension secondary to endocrine disorders.


In Utero Bowel Perforation

description: Bowel perforation in utero that may result in meconium peritonitis.


Benign congenital hypotonia

description: Mild hypotonia that usually appears early in infancy and has a favorable outcome. It is not a manifestation of another disorder that may cause hypotonia (e.g., cerebral palsy or muscular dystrophy).


Malignant biliary obstruction

description: Blockage in the biliary tract caused by a malignant neoplasm.


Hepatojugular Reflex

description: Distension of the neck veins precipitated by sustained pressure over the liver while patient is semi-recumbent. With normal heart function, pressure on the liver does not elevate the venous blood level in the neck veins.


Aortic Injury

description: Damage to the aorta from traumatic or pathologic processes.


Secondary caries

description: A carious lesion adjacent to an existing restoration.


Reflex

description: An automatic instinctive unlearned reaction to a stimulus.


Focal Motor Weakness

description: Impairments of brain function, the nerve or spinal cord that affect a specific region of the body.


psychogenic syncope

description: A condition in which syncope occurs due to a conversion disorder. (ACC/AHA)


Urostomy Site Bleeding

description: Hemorrhage from the urostomy site.


Spontaneous Preterm Birth

description: Preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes.


Peritumoral Brain Edema

description: An intracranial edema that develops around a tumor in the meninges or brain.


Perforation of jejunum

description: A rupture in the jejunal wall due to traumatic or pathologic processes.


Prostatic perforation

description: An opening in the prostate gland due to traumatic or pathologic processes.


Heat Sensation

description: An internal feeling of being warmer without a concomitant change in the ambient environment. (ACC/AHA)


Varicose veins of lower extremity

description: An abnormally dilated superficial vein in the legs.


Injury of cardiac valve

description: An event causes abnormal valve function; this is usually a tear in leaflet or chordae tendinae and manifests as a new regurgitant. (ACC)


Muscle Weakness Trunk

description: A reduction in the strength of the trunk muscles.


Blood Pressure Finding

description: A test result that reports the diastolic and systolic pressure of the blood.


name: Syncope with High Risk Cardiac Characteristics

description: A sudden loss of consciousness with loss of postural tone not related to anesthesia with high risk characteristics. High risk characteristics include non-ischemic dilated cardiomyopathy, or ischemic heart disease with significant ventricular dysfunction, hypertrophic cardiomyopathy, Brugada Syndrome, or Long QT Syndrome. (ACC)


name: COVID-19-Associated Acute Intestinal Injury

description: Acute intestinal injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Berry Aneurysm

description: A small cerebral artery aneurysm, characterized by a saccular appearance, that typically forms at the junction of vessels in the circle of Willis.


Cisplatin-Induced Tinnitus

description: Tinnitus that is caused by exposure to cisplatin.


Grade 3 Seizure, ASTCT ICANS

description: Any clinical seizure focal or generalized that resolves rapidly or nonconvulsive seizures on EEG that resolve with intervention, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


name: Congenital obstruction of ureteral orifice

description: Complete or partial blockage of the ureter at the point where it enters the bladder that is present at birth.


Digestive System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the digestive system.


Muscle Weakness Left-Sided

description: A reduction in the strength of the muscles in the left side of the body.


Ventricular Tachycardia by ECG Finding

description: An electrocardiographic finding of three or more consecutive complexes of ventricular organ with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC)


name: Varicose veins of lower extremities with inflammation

description: Inflammation of enlarged and tortuous veins in the hip, thigh, leg and/or foot.


Spermatic Cord Perforation

description: An opening in the wall of the spermatic cord.


Hemorrhage in bile duct

description: Bleeding originating from the bile duct.


Closed injury of eyeball

description: Traumatic injury to one or more intraocular structures without full thickness wound of the eyewall (sclera and cornea). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Hemorrhage of pancreas

description: Bleeding originating from the pancreas.


name: Cardiac Arrest Requiring Cardiopulmonary Resuscitation

description: Cardiac arrest that is treated by CPR and/or defibrillation, regardless of outcome.


Integumentary System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the integumentary system.


Diplopia, Unilateral

description: Perception of more than one image when viewing with one eye.


Neutrophilic Eccrine Hidradenitis

description: Painful red or pink edematous nodules most commonly found on the palmar and/or plantar regions.


Injury of nose

description: Trauma to the nose.


Traumatic chylothorax

description: Accumulation of lymph fluid in the pleural cavity as a result of thoracic trauma.


Jaundice, Hemolytic

description: Jaundice occurring as a result of red blood cell rupture.


Immune-Mediated Diarrhea

description: Diarrhea caused by an immune reaction to an antigen, including a therapeutically administered agent.


Indicated Preterm Birth

description: Preterm birth from 20 weeks to 36 weeks, and 6 days of gestation that is necessitated by the medical condition of the mother or fetus.


Arteriovenous graft stenosis

description: Narrowing of the lumen of an arteriovenous graft.


name: Acquired supradiaphragmatic diverticulum of esophagus


name: Pericardial Effusion Related to COVID-19

description: Pericardial effusion in a patient with probable or confirmed acute COVID-19.


Testicular perforation

description: A rupture through the testicular tissue.


Arrhythmia by ECG Finding

description: An arrhythmia that is detected on an electrocardiograph.


Late Pregnancy Loss

description: The loss of a pregnancy between 13 and 22 weeks.


Carious Dentin

description: Tooth decay that has invaded the dentin, creating dentin that is partially demineralized and containing mineral crystals in the tubules.


Myocardial Contusions

description: A bruise to the heart.


Faceplant

description: A syncopal event in which there is no attempt to protect oneself from the effects of the fall.


name: Injury to kidney with open wound into cavity

description: Trauma to the kidney associated with a break in the tissue that extends into the retroperitoneum.


Grade 4 Seizure, ASTCT ICANS

description: Life-threatening prolonged seizure (>5 min); or repetitive clinical or electrical seizures without return to baseline in between seizures, as defined by the American Society for Transplantation and Cellular Therapy (ASTCT) and the Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) Consensus Grading for Adults.


Congenital Testicular Failure

description: Testicular failure, the cause of which is present at birth.


Miscarriage in second trimester

description: Pregnancy loss between 14 weeks 0 days and 21 weeks 6 days gestation.


name: Multifocal Atrial Premature Complex by ECG Finding

description: An electrocardiographic finding of premature atrial complexes which have 2 or more distinct morphologies, suggesting origin at more than one atrial site. (CDISC)


description: Diminished mental function after chemotherapy.


Postpartum Shock

description: Severe loss of blood pressure leading to inadequate tissue perfusion after the delivery of the fetus.


name: Acquired solitary multilocular renal cyst

description: A single cyst in the kidney with several compartments.


name: injury of esophagus with open wound into cavity

description: Trauma to the esophagus associated with a break in the tissue that extends into the thoracic cavity.


Left Bundle Branch Block by ECG Finding

description: An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifested as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration greater than or equal to 120 ms. (CDISC)


Persistent Fetal Bradycardia

description: A decrease in the fetal heart beat rate below 110 per minute or below the normal baseline value expected for the particular fetal age for a period of more than 10 minutes.


Contusion of liver

description: Bruising of the liver.


Rupture of globe

description: Full thickness wound of the eyewall (cornea and/or sclera) due to blunt trauma. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Intraocular Pressure

description: The fluid pressure within the eye.


Persistent Fetal Tachycardia

description: A fetal heart rate above 160 bpm that is sustained for longer than 10 minutes.


name: Cardiogenic Shock Stage A Related to COVID-19

description: Clinical signs of warmth and perfusion without volume overload or hypoperfusion and with a normal cardiac index in a patient with probable or confirmed acute COVID-19 that is not currently experiencing signs or symptoms of cardiogenic shock but is at risk for its development. These patients may include those with large acute myocardial infarction or prior infarction, or those with acute or acute on chronic heart failure symptoms.


Cardiac Arrest Requiring Defibrillation

description: Cardiac arrest that is treated by defibrillation, regardless of outcome.


Peripheral Embolus

description: Acute occlusion of a peripheral blood vessel resulting from intravascular migration of material. Examples of embolic material include thrombus, fat, bone marrow, air, and amniotic fluid. (ACC)


name: Injury of liver without open wound into abdominal cavity

description: Trauma to the liver without indication of associated damage to the skin and other internal and external tissues.


Left ventricular aneurysm

description: A bulge or ballooning in the wall of the left ventricle of the heart.


Spontaneous rupture of urinary bladder

description: Rupture in the bladder wall due to a pathologic process, in the absence of trauma.


Distributive Shock Related to COVID-19

description: Systemic vasodilation leading to decreased blood flow to organs in a patient with probable or confirmed acute COVID-19.


Cerebral Venous Aneurysm

description: A balloon type pouch or bulge in the wall of a cerebral vein.


Rectal Obstruction

description: Blockage of the normal flow of the intestinal contents in the rectum.


Foot Injuries

description: Trauma to the foot.


Urethral Perforation

description: A rupture in the wall of the urethra due to traumatic or pathologic processes.


Intraoperative Hepatobiliary Injury

description: Damage to the hepatic parenchyma and biliary tract during a surgical procedure.


Central nervous system epidermoid tumor

description: A lesion which is characterized by an irregularly nodular opalescent wall which has caused it to be termed a "pearly tumor". The Intramural contents are soft and waxy with a variable amount of cholesterol.


Laryngopharyngeal Dysesthesia

description: A disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.


Legally Induced Abortion

description: Lawfully induced expulsion of all products of conception.


Prostatic Obstruction

description: Squeezing of the urethra secondary to enlargement of the prostate gland, resulting in voiding symptoms (straining to void, slow urine stream, and incomplete emptying of the bladder).


name: Frequent Premature Atrial Complexes by ECG Finding

description: An electrocardiographic tracing demonstrating frequent premature atrial contractions that exceed an acceptable, predetermined threshold. Different thresholds may apply to different patient populations.


Decreased Best Corrected Visual Acuity

description: Diminished clarity of vision despite optimal optical correction (glasses and/or contacts).


Eye Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the eye.


Lupus Headache

description: A severe, persistent headache that occurs in patients with systemic lupus erythematosus, and is nonresponsive to narcotic analgesia.


Unspecified postpartum hypertension

description: High blood pressure in the period of time immediately after labor and delivery.


idiopathic precocious puberty

description: Precocious puberty for which no underlying cause can be identified.


Normal Sinus Rhythm

description: An electrocardiographic finding of an atrial rhythm which originates from the sinoatrial node that is considered normal for the population. There are no extra beats or conduction abnormalities. (CDISC)


Late Preterm Birth

description: Birth when a fetus is between 34 weeks and 0 days through 36 weeks and 6 days gestational age.


Back Arching

description: A convex curvature of the spine that occurs when an individual thrusts forward the shoulders and pulls back the abdomen.


Antepartum Stillbirth

description: Fetal death greater than or equal to 20 weeks of gestation prior to labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.


Injury of pancreas

description: Trauma to the pancreas.


Syncope due to Pulmonary Hypertension

description: A condition in which syncope occurs associated with a sudden and severe increase in pulmonary vascular resistance. (ACC/AHA)


Pharyngeal Dysesthesia

description: An unusual sensation in the area of pharynx. It may be the initial manifestation of seizures associated with temporal lobe epilepsy.


Vessel perforation

description: Damage to a blood vessel resulting from a full thickness disruption in the integrity of the vessel wall.


Foreign Body in Digestive Tract

description: Extraneous material located within the gastrointestinal tract.


Ocular Contusion

description: A closed globe injury without violation of the eyewall (cornea and/or sclera), resulting in injury to one or more intraocular structures. (adapted from the Birmingham Eye Trauma Terminology System (BETTS))


Acute Ischemic Limb Related to COVID-19

description: A sudden or severe decrease in limb perfusion in a patient with probable or confirmed acute COVID-19, usually producing new or worsening symptoms or signs, and often threatening limb viability or resulting in limb amputation.


Atrial perforation

description: A rupture in atrial tissue due to traumatic or pathologic processes.


Cardiovascular System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the cardiovascular system.


Second trimester bleeding

description: Excessive blood loss within the second trimester but prior to onset of labor.


Superior vena cava stenosis

description: Abnormal narrowing of the lumen of the superior vena cava.


Cold Sensation

description: An internal feeling of being cooler without a concomitant change in the ambient environment. (ACC/AHA)


Injury to Inferior Vena Cava

description: Damage to the inferior vena cava from traumatic or pathologic processes.


Immune System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the immune system.


Syncope Related to COVID-19

description: Syncope in a patient with probable or confirmed acute COVID-19.


Cyst of parathyroid

description: An epithelium-lined, fluid-filled cyst containing parathyroid hormone that is usually located in an inferior parathyroid gland, but may be found in other locations in the neck or mediastinum.


Malignant pericardial effusion

description: Presence of fluid in the pericardial space as a complication of malignant disease.


Laceration of esophagus

description: A torn, ragged, mangled wound, or an accidental cut of esophagus.


Bladder hemorrhage

description: Bleeding originating from the urinary bladder wall.


Miscarriage in first trimester

description: Pregnancy loss at less than 14 weeks 0 days gestation.


Hemorrhage from ureter

description: Bleeding originating from the ureter.


Head and Neck Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the head and neck.


Dissecting Thoracic Aortic Aneurysm

description: A dissecting aneurysm formed between the intimal and medial layers of the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.


Fetal Finding

description: Any intrauterine symptom or result related to the fetus.


name: Incomplete Right Bundle Branch Block by ECG Finding

description: An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration less than 120 ms. (CDISC)


Disturbance in Bowel Function

description: Abnormal functioning of the small and/or large intestine.


name: Unifocal Atrial Premature Complex by ECG Finding

description: An electrocardiographic finding of premature atrial complexes which have a single distinct morphology, suggesting origin at one atrial site.


Acquired chylothorax

description: Chylothorax that results from malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, or sarcoidosis.


Heart Injuries

description: Trauma to the cardiac muscle or valves.


Respiratory System Finding

description: Symptoms, physical examination results, and/or laboratory test results related to the respiratory system.


Refractory Erectile Dysfunction

description: Erectile dysfunction that does not respond to treatment.


Level of Consciousness

description: The level of awareness of an organism.


name: Locally Advanced Malignant Peripheral Nerve Sheath Tumor

description: A malignant peripheral nerve sheath tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


Vulvar Acquired Melanocytic Nevus

description: A benign nevus that arises from the vulva during childhood and grows with increasing age.


COCARBOXYLASE

An organic chloride salt of thiamine(1+) diphosphate.


category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion.


right lung

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].


left lung

description: Lung which consists of the left upper lobe and left lower lobe.[FMA].


Mucous polyp of cervix

description: A polypoid lesion that arises from the cervix and contains mucus.


WHO Grade 1 Glioma

description: A category of low grade gliomas that includes subependymal giant cell astrocytoma, pilocytic astrocytoma, angiocentric glioma, and subependymoma.


Adult Myxopapillary Ependymoma

description: A myxopapillary ependymoma that occurs during adulthood.


Adult Pilocytic Astrocytoma

description: A pilocytic astrocytoma occurring in adults.


Recurrent WHO Grade 1 Glioma

description: The reemergence of WHO grade 1 glioma after a period of remission.


Adult Subependymoma

description: A subependymoma that occurs during adulthood.


Refractory WHO Grade 1 Glioma

description: WHO grade 1 glioma that is resistant to treatment.


name: Adult Subependymal Giant Cell Astrocytoma

description: A subependymal giant cell astrocytoma occurring in adults.


Childhood Myxopapillary Ependymoma

description: A myxopapillary ependymoma that occurs during childhood.


name: Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

description: Stage II includes: T2, N0, M0. T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Perinatal intracranial hemorrhage

description: Bleeding within the skull of a newborn infant occurring around the time of birth.


Perinatal intraventricular hemorrhage

description: Bleeding within the cerebral ventricles occurring around the time of birth.


name: Perinatal subependymal hemorrhage with intraventricular and intracerebral extension

description: A hemorrhage that involves the subependymal region, the lateral cerebral ventricles and the brain tissue occurring around the time of birth.


Subependymal haemorrhage

description: Bleeding within the subependymal germinal matrix.


name: Intraventricular hemorrhage of prematurity

description: Bleeding within the cerebral ventricles in a preterm infant.


Intracranial tumor hemorrhage

description: A  brain hemorrhage caused by an intracranial tumor.


name: Intraventricular Hemorrhage Related to Birth

description: Bleeding into the cerebral ventricles that occurs during labor and/or delivery.


name: Grade 2 Intraventricular Hemorrhage of the Newborn

description: Bleeding into the lateral cerebral ventricles of a newborn infant without acute ventricular dilatation.


name: Intraventricular (nontraumatic) hemorrhage, grade 3, of fetus and newborn

description: Bleeding into the lateral cerebral ventricles of a newborn infant with ventricular dilatation directly attributable to the acute bleeding.


name: Intracranial Hemorrhage Related to Birth

description: Bleeding within the skull of a newborn infant occurring during labor and/or delivery.


name: Intraventricular Hemorrhage with Parenchymal Hemorrhage of the Newborn

description: Bleeding into the lateral cerebral ventricles and the adjacent brain tissue of a newborn infant.


Cerebral Hemorrhage Related to Birth

description: Intracranial bleeding in the tissue of the cerebrum of a newborn infant occurring during labor and/or delivery.


Parotid Gland Warthin Tumor

description: An adenoma that arises from the parotid gland. It is characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland.


Skin Cavernous Hemangioma

description: A cavernous hemangioma arising from the skin.


Penile Lymphoepithelioma-Like Carcinoma

description: A variant of penile squamous cell carcinoma characterized by the presence of islands of malignant cells with uniform vesicular nuclei and prominent nucleoli, and a dense lymphocytic infiltrate.


Penile Carcinoma Cuniculatum

description: A variant of verrucous carcinoma of the penis. It is characterized by a labyrinthine growth pattern.


Penile Lymphoma

description: A lymphoma that arises from penile skin, subcutis, corpora cavernosa, and spongiosum. Diffuse large B-cell lymphoma is the most common primary penile lymphoma. (WHO 2016)


Stage 0is Penile Cancer AJCC v8

description: Stage 0is includes: Tis, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Refractory Penile Carcinoma

description: Penile carcinoma that is resistant to treatment.


Penile Lymphangioma

description: A lymphangioma that occurs in the skin of the penis.


Childhood Malignant Penile Neoplasm

description: A rare malignant neoplasm of the penis that occurs during childhood.


Stage IIA Penile Cancer AJCC v8

description: Stage IIA includes: (T1b, N0, M0); (T2, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage III Penile Cancer AJCC v8

description: Stage III includes: IIIA: T1-3, N1, M0; IIIB: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N1: Penile cancer with two or less unilateral inguinal metastases, no extranodal extension. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


Penile Hemangioma

description: A hemangioma that occurs in the skin of the penis.


name: Grade II Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower two thirds of the epithelial thickness.


Penis carcinoma recurrent

description: A carcinoma of the penis that reappears after a period of remission.


Unresectable Penile Carcinoma

description: Penile carcinoma that is not amenable to surgical resection.


Penile Mucosal Melanoma

description: A melanoma that arises from the mucosa of the penis.


name: Penile Human Papillomavirus-Independent Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the penis and is not caused by human papillomavirus infection. Morphologic variants include pseudohyperplastic, pseudoglandular, verrucous, papillary, and sarcomatoid carcinoma.


Penile intraepithelial neoplasia

description: A precancerous neoplastic lesion that arises from the penis. It is characterized by dysplastic changes of the squamous epithelium with an intact basement membrane.


Bowenoid papulosis of penis

description: A cutaneous, usually multifocal lesion in the penis characterized by the presence of verrucous papules.  It is caused by human papillomavirus infection.  Morphologically there is bowenoid dysplasia present.  Progression to invasive carcinoma is infrequent.


Penile Schwannoma

description: A schwannoma that occurs in the penis.


Myointimoma

description: A rare benign mesenchymal neoplasm that occurs in the glans and corpora of the penis. It is characterized by the proliferation of spindle-shaped myofibroblasts in the intravascular spaces.


Penile Neurofibroma

description: A neurofibroma that occurs in the penis.


name: Basaloid (Undifferentiated) Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by full-thickness replacement of the squamous epithelium by immature, small, monotonous, basophilic cells. The cells have round to oval nuclei, inconspicuous nucleoli, and scant cytoplasm. Apoptosis and mitotic figures are prominent. (WHO 2016)


Stage IV Penile Cancer AJCC v8

description: Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1). T4: Penile cancer with tumor invading into adjacent structures (i.e., scrotum, prostate, pubic bone). N3: Penile cancer with extranodal extension of lymph node metastases or pelvic lymph node metastases. M1: Distant metastasis present. (AJCC 8th ed.)


name: Penile Clear Cell Squamous Cell Carcinoma

description: A variant of penile squamous cell carcinoma characterized by the presence of malignant cells with clear cytoplasm.


name: Penile Squamous Cell Carcinoma, Not Otherwise Specified

description: A penile squamous cell carcinoma characterized by the absence of special morphologic features and lack of information on p16 immunohistochemistry and human papilloma virus testing status.


name: Warty (Bowenoid) Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by a slightly spiking papillomatous surface with atypical parakeratosis. There is prominent cellular pleomorphism, koilocytosis, and mitoses. Unlike in basaloid penile intraepithelial neoplasia, there is squamous maturation. (WHO 2016)


Stage IIIA Penile Cancer AJCC v8

description: Stage IIIA includes: T1-3, N1, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N1: Penile cancer with two or less unilateral inguinal metastases, no extranodal extension. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIB Penile Cancer AJCC v8

description: Stage IIB includes: T3, N0, M0. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Condyloma Acuminatum

description: A human papillomavirus-related benign neoplasm affecting the penis. Most often it arises from the glans penis in young men. It usually presents with a nodular wart. Morphologically, it is characterized by an exophytic papillary proliferation of squamous cells and acanthosis. Most cases either resolve spontaneously or do not recur following removal.


Penile Adenosquamous Carcinoma

description: An extremely rare carcinoma that arises from the penis and is characterized by the presence of glandular and squamous components.


Penile Cancer by AJCC v8 Stage

description: A term that refers to the staging of penile cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to penile squamous cell carcinoma and associated histologic subtypes. It does not apply to urethral carcinomas, sarcomas, and melanomas. (from AJCC 8th Ed.)


name: Unresectable Penile Squamous Cell Carcinoma

description: Penile squamous cell carcinoma that is not amenable to surgical resection.


Penile Cutaneous Melanoma

description: A melanoma that arises from the skin of the penis.


name: Differentiated penile intraepithelial neoplasia

description: Intraepithelial neoplasia of the penis that is not caused by human papillomavirus infection. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present. It is characterized by a thickened epithelium, subtle abnormal cellular maturation, and atypical basal layer cells. Parakeratosis is common. (WHO 2016)


Penile Pseudohyperplastic Carcinoma

description: A multifocal, extremely differentiated squamous cell carcinoma of the penis. It typically occurs in older patients and is associated with lichen sclerosus.


Adult Penile Carcinoma

description: A carcinoma of the penis that occurs during adulthood.


Penile Epithelioid Hemangioendothelioma

description: An epithelioid hemangioendothelioma that occurs in the penis.


Penile Leiomyoma

description: A leiomyoma that occurs in the penis.


Penile Soft Tissue Neoplasm

description: A rare mesenchymal neoplasm that arises from the penis.


Penile Pseudoglandular Carcinoma

description: A penile squamous cell carcinoma characterized by the formation of gland-like structures.


Stage 0 Penile Cancer AJCC v8

description: Stage 0 includes: 0is: Tis, N0, M0; 0a: Ta, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Stage IIIB Penile Cancer AJCC v8

description: Stage IIIB includes: T1-3, N2, M0. T1: Glans: Penile cancer with tumor invading lamina propria. Foreskin: Penile cancer with tumor invading dermis, lamina propria, or dartos fascia. Shaft: Penile cancer with tumor invading connective tissue between epidermis and corpora regardless of location. All sites with or without lymphovascular invasion or perineural invasion and is or is not high grade. T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N2: Penile cancer with three or more unilateral inguinal metastases or bilateral metastases. M0: No distant metastasis. (AJCC 8th ed.)


name: Human Papillomavirus-Related Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis caused by human papillomavirus infection.


name: Penile Malignant Peripheral Nerve Sheath Tumor

description: A rare malignant peripheral nerve sheath tumor that occurs in the penis.


Penile Papillary-Basaloid Carcinoma

description: A variant of penile basaloid squamous cell carcinoma. It is characterized by a papillary exophytic or endophytic growth pattern.


Stage 0a Penile Cancer AJCC v8

description: Stage 0a includes: Ta, N0, M0. Ta: Penile cancer with a finding of noninvasive localized squamous cell carcinoma. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


name: Low Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower one third of the epithelial thickness.


Penile Epithelioid Hemangioma

description: An epithelioid hemangioma that occurs in the skin of the penis.


name: High Grade Penile Intraepithelial Neoplasia

description: Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy either the lower two thirds of the epithelial thickness (grade II) or the entire thickness of the epithelium (grade III, Bowen atypia, or squamous cell carcinoma in situ).


Stage II Penile Cancer AJCC v8

description: Stage II includes: IIA: (T1b, N0, M0); (T2, N0, M0); IIB: (T3, N0, M0). T1b: Penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid). T2: Penile cancer with tumor invading into corpus spongiosum (either glans or ventral shaft) with or without urethral invasion. T3: Penile cancer with tumor invading into corpora cavernosum (including tunica albuginea) with or without urethral invasion. N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Warty-Basaloid Carcinoma

description: A squamous cell carcinoma that arises from the penis. It is characterized by warty (condylomatous) and basaloid features.


Penile Angiosarcoma

description: A rare angiosarcoma that affects the penis.


name: Warty-Basaloid Penile Intraepithelial Neoplasia

description: Intraepithelial neoplasia of the penis characterized by the presence of a variable mixture of warty and basaloid cells. (WHO 2016)


melanoma of penis

description: A melanoma that arises from the penis. It may be cutaneous or mucosal. The most common site of involvement is glans penis.


Metastatic Penile Cancer

description: Carcinoma of the penis that has spread from its original site of growth to another anatomic site.


Stage I Penile Cancer AJCC v8

description: Stage I includes: T1a, N0, M0. T1a: Penile cancer with tumor without lymphovascular invasion or perineural invasion and is not high grade (i.e., grade 3 or sarcomatoid). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Penile Mucoepidermoid Carcinoma

description: An extremely rare carcinoma that arises from the penis and is characterized by the presence of mucinous and squamous components.


Penile Rhabdomyosarcoma

description: A rhabdomyosarcoma that occurs in the penis. It usually affects young children. Embryonal rhabdomyosarcoma is the most common type.


Locally Advanced Penile Carcinoma

description: Penile carcinoma that has spread to nearby tissues or lymph nodes.


Current Hepatitis B Infection

description: Hepatitis B infection is evident at the time of testing.


Vein of the Head or Neck

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any blood vessel within in the head or neck that transports deoxygenated blood.


Acute Intrapartum Hypoxic Event

description: A sentinel hypoxic event occurring during labor, with evidence of fetal metabolic acidosis in the fetal umbilical arterial blood; a sudden and sustained fetal bradycardia or the absence of fetal heart rate variability in the presence of persistent, late, or variable decelerations (category III tracing); previously normal Apgar scores that are 0-3 beyond 5 minutes.


Stage IIIB Anal Cancer AJCC v8

description: Stage IIIB includes: T4, N0, M0. T4: Tumor of any size invading adjacent organ(s), such as the vagina, urethra, or bladder. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


amino acid transport complex

description: A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane.


name: anterior inferior pancreaticoduodenal lymph node

description: Inferior pancreaticoduodenal lymph node located on the anterior aspect of inferior region of head of pancreas.


name: posterior inferior pancreaticoduodenal lymph node

description: Inferior pancreaticoduodenal lymph node located on the posterior aspect of inferior region of head of pancreas.


repressor ecdysone receptor complex

description: A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.


vagus X nerve trunk

description: A nerve trunk that is part of a vagus nerve.


Esophageal Fistula

description: An abnormal communication between the esophagus and another organ or anatomic site.


name: smooth muscle tissue of respiratory bronchiole

description: A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition].


name: Uterine Corpus Spindle Smooth Muscle Tumor of Uncertain Malignant Potential

description: A smooth muscle tumor of uncertain malignant potential that arises from the uterine corpus and is composed of neoplastic spindle cells.


description: A rare serous cystadenocarcinoma that arises from the paratesticular structures.


D-threonine

An optically active form of threonine having D-configuration.


name: Fumarate Hydratase-Deficient Renal Cell Carcinoma

description: A rare, highly aggressive renal cell carcinoma caused by germline or (in a subset) somatic mutation of fumarate hydratase gene. It arises mostly in the setting of hereditary leiomyomatosis-renal cell carcinoma syndrome.


Acephalostomia

description: A congenital defect characterized by the absence of most or all of the head, with the presence of a mouth-like opening on the upper thorax.


Myositis, Proliferative

description: A rapidly growing, poorly circumscribed, mass-forming proliferation that arises from the skeletal muscle. It is characterized by the presence of spindle-shaped fibroblasts, round ganglion-like cells, myxoid to collagenous stroma formation, and high mitotic activity. It recurs only rarely following local excision and does not metastasize.


Pancreatic Beta Cell Adenoma

description: An adenoma arising from the beta cells of the pancreas.  It produces insulin.


Carcinoma of lower gum

description: A carcinoma of the oral cavity that arises from the lower gingiva.


Carcinoma of upper gum

description: A carcinoma of the oral cavity that arises from the upper gingiva.


Gingival Spindle Cell Carcinoma

description: A poorly differentiated squamous cell carcinoma that arises from the gingiva. It is characterized by the presence of malignant pleomorphic spindle cells.


Gingival Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the gingival mucosa. It presents as an ulcerated lesion or exophytic mass. The prognosis is usually poor.


Gingival Angiofibroma

description: A benign neoplasm arising from the fibrous soft tissues of the gingiva. It is characterized by the presence of spindle-shaped fibroblasts and numerous dilated vascular channels.


squamous cell carcinoma of lower gum

description: A squamous cell carcinoma of the oral cavity that arises from the lower gingiva.


carcinoma of gingiva

description: A carcinoma of the oral cavity that arises from the upper or lower gingiva.


squamous cell carcinoma of upper gum

description: A squamous cell carcinoma of the oral cavity that arises from the upper gingiva.


name: Retromolar Trigone Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the retromolar trigone. Pain, often radiating to the ear, is the presenting symptom. The prognosis is poor.


seminal clot

description: A portion of semen in a coagulated state.


nacre

description: An organic-inorganic composite material produced by some mollusks as an inner shell layer; it is also what makes up pearls. It is very strong, resilient, and iridescent. Nacre is found in some ancient lineages of bivalve gastropod and cephalopod. The inner layer in the great majority of mollusk shells is porcellaneous, not nacreous, frequently resulting in a non-iridescent shine or less commonly in non-nacreous iridescence such as flame structure (e.g. conch pearl). Pearls and the inside layer of pearl oyster and freshwater pearl mussel shells are made of nacre. Many other families of mollusk also have a nacreous inner shell layer, including marine gastropods such as the Haliotidae, the Trochidae and the Turbinidae. Nacre is composed of hexagonal platelets of aragonite (a form of calcium carbonate) 10-20 µm wide and 0.5 µm thick arranged in a continuous parallel lamina. These layers are separated by sheets of organic matrix composed of elastic biopolymers (such as chitin, lustrin and silk-like proteins)[WP].


scrotal sweat

description: Any portion of sweat that is produced by a sweat gland of the scrotum.


mammary gland fluid/secretion

description: A substance that is secreted by a mammary gland. The substance may differ depending on phase, with colostrum produced during pregancy/early lactation, and milk produced afterwards.


ocular refractive media

description: Body substance in a liquid or semi-solid state in the eyeball which serves to refract light.


excreta

description: A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.


bulbourethral gland secretion

description: A bodily secretion that is produced by a bulbourethral gland.


meibum

description: An oily substance that prevents evaporation of the eye's tear film.


bodily fluid

description: Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.


sweat of palm

description: Sweat that is produced by the glands on the palmar and plantar surfaces.


haemolymphatic fluid

description: Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.


milk

description: An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation.


meconium

description: A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth.


secretion of exocrine gland

description: A portion of organism substance that is produced by exocrine glands.


sweat of axilla

description: Sweat that is produced by the glands of the axilla.


secretion of serous gland

description: Any fluid produced by a serous gland.


mating plug

description: A gelatinous secretion used in the mating of some species. It is deposited by a male into a female genital tract and later hardens into a plug or glues the tract together.


transudate

description: Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.


seminal vesicle fluid

description: A bodily secretion that is produced by a seminal vesicle.


prostate gland secretion

description: A bodily secretion that is produced by the prostate gland.


name: Paranasal sinus teratocarcinosarcoma (type)

description: A malignant sinonasal neoplasm with combined histological features of teratoma and carcinosarcoma, lacking malignant germ cell components. (WHO 2017)


carcinosarcoma of salivary gland

description: An aggressive, high grade malignant tumor that arises from the salivary gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Lacrimal Gland Carcinosarcoma

description: An aggressive, high grade malignant neoplasm that arises from the lacrimal gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.


Pleomorphic adenoma of parotid gland

description: A benign, slow-growing tumor that arises from the parotid gland.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin and women are more often affected than men.


name: Recurrent Childhood Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma in childhood after a period of remission.


name: Malignant Mixed Tumor of the Major Salivary Gland

description: A malignant tumor arising from the parotid gland, submandibular gland, or sublingual gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Conjunctival Adenosquamous Carcinoma

description: A carcinoma that arises from the conjunctiva. It is characterized by the presence of a variable combination of squamous (epidermoid) cells and mucous cells, arranged in invasive sheets, cords, and ducts. (WHO 2018)


name: Stage III Uterine Corpus Adenosarcoma AJCC v8

description: Stage III includes: IIIA: T3a, N0, M0; IIIB: T3b, N0, M0; IIIC: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Adenocarcinoma with cartilaginous and osseous metaplasia

description: An invasive adenocarcinoma characterized by focal or extensive cartilage and/or bone formation.


Recurrent Anaplastic Oligoastrocytoma

description: The reemergence of anaplastic oligoastrocytoma after a period of remission.


Uterine Carcinosarcoma, Homologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements that arise from the tissues of the uterus.


name: Uterine Corpus Adenosarcoma by AJCC v8 Stage

description: A term that refers to the staging of uterine corpus adenosarcoma according to the American Joint Committee on Cancer, 8th edition.


name: Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component.


name: Metastatic Endometrial Adenosquamous Carcinoma

description: Endometrial adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: mixed acinar-endocrine carcinoma of pancreas

description: A carcinoma that arises from the pancreas and is composed of acinar carcinoma and neuroendocrine carcinoma components in both the primary tumor and the metastatic sites.


name: Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm

description: A neoplasm that arises from the cervix and is characterized by the presence of benign epithelial and benign mesenchymal elements. This category includes adenofibroma and adenomyoma.


Primary peritoneal carcinosarcoma

description: An extremely rare and highly aggressive malignant neoplasm arising from the peritoneum.  Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.


Hybrid Salivary Gland Tumor

description: A rare neoplasm that arises from the salivary gland and consists of at least two histologically distinct types of tumor within the same topographic location. The tumor components can be either benign or malignant.


name: Uterine Carcinosarcoma, Heterologous Type

description: A carcinosarcoma of the uterus characterized by the presence of sarcomatous elements composed of tissues that are not found in the uterus (e.g., bone, cartilage, skeletal muscle).


name: Appendix Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the appendix.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Metastasizing Pleomorphic Adenoma of the Salivary Gland

description: A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features.  The most common sites of metastasis are bone, lung, and head and neck.


Oropharyngeal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the oropharynx.


name: Stage IIIA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIA includes: T3a, N0, M0. T3a: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Borderline Serous Cystadenofibroma

description: A neoplasm of low malignant potential arising from a site in the female reproductive system. Almost all cases have been reported in the ovary. It is characterized by the presence of cystic spaces which are lined by atypical serous epithelial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion.


Advanced Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage IIIC Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Advanced Malignant Mixed Mesodermal (Mullerian) Tumor

description: A malignant mixed mesodermal (Mullerian) tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage I Uterine Corpus Adenosarcoma AJCC v8

description: Stage I includes: T1, N0, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Metastatic Cervical Adenosquamous Carcinoma

description: A cervical adenosquamous carcinoma that has spread to another anatomic site.


name: Testicular Mixed Choriocarcinoma and Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Metastatic Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Skin Squamous Cell Carcinoma with Sarcomatoid Differentiation

description: A rare carcinoma of the skin characterized by the presence of squamous cell carcinomatous and sarcomatous components.


Sellar Mixed Germ Cell Tumor

description: A mixed germ cell tumor that arises from or adjacent to the sellar region.


Cellular Pleomorphic Adenoma

description: A pleomorphic adenoma with increased cellularity.


name: Metastatic Vaginal Adenosquamous Carcinoma

description: Vaginal adenosquamous carcinoma that has spread from its original site of growth to another anatomic site.


name: Anal Canal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the anal canal.  It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Recurrent Childhood Oligoastrocytoma

description: The reemergence of oligoastrocytoma in childhood after a period of remission.


Hard Palate Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the minor salivary glands in the hard palate.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


carcinosarcoma of gallbladder

description: A carcinoma that arises from the gallbladder and it is characterized by the presence of a sarcomatous component.  The sarcomatous component may contain osteosarcoma, chondrosarcoma, or rhabdomyosarcoma elements.


name: Mixed neuroendocrine-non neuroendocrine neoplasm

description: A rare neoplasm that consists of neuroendocrine and non-neuroendocrine cellular components. At least 30% of either component should be present for the diagnosis to be made.


name: Metastatic Uterine Corpus Carcinosarcoma

description: Uterine corpus carcinosarcoma that has spread from its original site of growth to another anatomic site.


name: Pancreatic Mixed Ductal Adenocarcinoma-Neuroendocrine Tumor

description: A very rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine tumor component.


name: Testicular Mixed Embryonal Carcinoma and Teratoma

description: A malignant mixed germ cell tumor arising from the testis, characterized by the presence of an embryonal carcinomatous component and a teratomatous component.


name: Gallbladder Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the gallbladder and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Sinonasal Pleomorphic Adenoma

description: A pleomorphic adenoma that arises from the sinonasal tract.


Metastatic Carcinosarcoma

description: Carcinosarcoma that has spread from its original site of growth to another anatomic site.


Recurrent Fallopian Tube Carcinosarcoma

description: The reemergence of fallopian tube carcinosarcoma after a period of remission.


Hybrid Salivary Gland Carcinoma

description: A rare carcinoma that arises from the salivary gland and consists of at least two histologically distinct types of carcinoma within the same topographic location. The carcinoma components usually are adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, and/or salivary duct carcinoma. Adenoid cystic carcinoma is commonly the predominant component.


Adult Mixed Glioma

description: A mixed glioma that occurs during adulthood.


Malignant chondroid syringoma

description: A rare malignant skin neoplasm that arises from a benign mixed tumor of the skin (chondroid syringoma).


Uterine Ligament Adenomyoma

description: A benign neoplasm that arises from the broad or other uterine ligaments. It is characterized by the presence of a glandular and a mesenchymal component.


name: Testicular Mixed Choriocarcinoma and Embryonal Carcinoma

description: A malignant mixed germ cell tumor that arises from the testis and is characterized by the presence of choriocarcinoma and embryonal carcinoma morphologic components.


name: Stage IIIB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IIIB includes: T3b, N0, M0. T3b: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues at more than one site. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Mixed parotid tumor

description: A benign or malignant neoplasm that arises from the parotid gland.  It is characterized by the presence of epithelial and mesenchymal elements.  This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma.


name: Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal-Type

description: A very rare testicular germ cell tumor that combines teratoma and yolk sac tumor. It usually affects young children. It is not associated with chromosome 12p amplification or germ cell neoplasia in situ.


Childhood Oligoastrocytoma

description: An oligoastrocytoma that occurs during childhood.


name: Gastric Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the stomach and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


name: Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma

description: A carcinoma that arises from a pleomorphic adenoma in the minor salivary glands.  Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months.  Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis.  In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.


Oral Cavity Pleomorphic Adenoma

description: A benign, slow-growing and painless neoplasm that arises from the salivary glands in the oral cavity.  It is composed of cells that demonstrate both epithelial and mesenchymal differentiation.


name: Stage IA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IA includes: T1a, N0, M0. T1a: Uterine corpus adenosarcoma with tumor limited to the endometrium/endocervix. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of choriocarcinoma and yolk sac tumor morphologic elements.  Patients may present with painless or painful testicular swelling.


Recurrent Oligoastrocytoma

description: The reemergence of oligoastrocytoma after a period of remission.


name: Pancreatic Mixed Ductal-Neuroendocrine Neoplasm

description: A rare mixed neuroendocrine non-neuroendocrine neoplasm that arises from the pancreas and is composed of ductal adenocarcinoma and a neuroendocrine neoplastic component. The latter is usually a poorly differentiated neuroendocrine carcinoma and rarely a well differentiated neuroendocrine tumor.


name: Testicular Mixed Yolk Sac Tumor and Teratoma

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac and teratomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Malignant Submandibular Gland Mixed Tumor

description: A malignant tumor arising from the submandibular gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


name: Benign Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm

description: A non-metastasizing neoplasm that arises from the uterine corpus and is composed of epithelial and mesenchymal elements. Representative examples include adenomyoma and adenofibroma.


name: Testicular Mixed Yolk Sac Tumor and Teratoma with Seminoma

description: A malignant germ cell tumor arising from the testis.  It is characterized by a mixture of yolk sac, teratomatous, and seminomatous morphologic elements.  Patients may present with painless or painful testicular swelling.


Mixed Carcinoma

description: A carcinoma characterized by the presence of more than one malignant epithelial histologic pattern.


name: Stage IVB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVB includes: Any T, Any N, M1. M1: M1: Distant metastasis (excluding adnexa, pelvic, and abdominal tissues). (from AJCC 8th Ed.)


name: Recurrent Cervical Adenosquamous Carcinoma

description: The reemergence of cervical adenosquamous carcinoma after a period of remission.


name: Stage IB Uterine Corpus Adenosarcoma AJCC v8

description: Stage IB includes: T1b, N0, M0. T1b: Uterine corpus adenosarcoma with tumor invading to less than half of the myometrium. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


name: Recurrent Primary Peritoneal Carcinosarcoma

description: The reemergence of primary peritoneal carcinosarcoma after a period of remission.


name: Malignant Mixed Tumor, Not Otherwise Specified

description: A malignant myoepithelioma characterized by the presence of a minor ductal component.


Childhood Anaplastic Oligoastrocytoma

description: An anaplastic oligoastrocytoma that occurs during childhood.


Childhood Breast Fibroadenoma

description: A fibroadenoma that arises from the breast and occurs during childhood.


name: Ampulla of Vater Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the ampulla of Vater and the periampullary region. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Childhood Mixed Glioma

description: A mixed glioma that occurs during childhood.


name: Stage II Uterine Corpus Adenosarcoma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


adenosquamous carcinoma of tongue

description: A rare adenosquamous carcinoma that arises from the tongue.


name: Testicular Mixed Embryonal Carcinoma and Seminoma

description: A malignant mixed germ cell tumor arising from the testis.  It is characterized by the presence of a mixture of embryonal carcinoma and a seminomatous component.


name: Refractory Uterine Corpus Carcinosarcoma

description: Uterine Corpus Carcinosarcoma that is resistant to treatment.


Advanced Carcinosarcoma

description: Carcinosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Choriocarcinoma combined with other germ cell elements

description: A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous component admixed with another germ cell component (e.g. embryonal carcinoma, teratoma, or seminoma).


name: Recurrent Endometrial Adenosquamous Carcinoma

description: The reemergence of endometrial adenosquamous carcinoma after a period of remission.


name: Malignant Vaginal Mixed Tumor Resembling Synovial Sarcoma

description: A very rare malignant mixed epithelial and mesenchymal neoplasm that arises from the vagina and resembles synovial sarcoma.  It is characterized by a biphasic pattern and is composed of gland-like structures that are lined by epithelial cells and a cellular mesenchymal component.


Malignant Parotid Gland Mixed Tumor

description: A malignant tumor arising from the parotid gland.  It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.


Odontogenic Carcinosarcoma

description: An extremely rare malignant mixed odontogenic neoplasm in which both the epithelial and the mesenchymal components are cytologically malignant. (WHO 2017)


name: Advanced Pancreatic Adenosquamous Carcinoma

description: Pancreatic adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Invasive Bladder Mixed Carcinoma

description: An invasive bladder carcinoma characterized by the presence of more than one histologic pattern.


name: Human Papillomavirus-Related Adenosquamous Carcinoma

description: An adenosquamous carcinoma associated with the presence of human papillomavirus infection.


name: Esophageal Mixed Adenoneuroendocrine Carcinoma

description: A carcinoma that arises from the esophagus and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component.  At least 30 percent of either component should be present for the diagnosis to be made.


Vaginal Adenosquamous Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the presence of malignant glandular and malignant squamous epithelial components.


Laryngeal Pleomorphic Adenoma

description: A very rare pleomorphic adenoma that arises from the larynx.


name: Stage IVA Uterine Corpus Adenosarcoma AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Uterine corpus adenosarcoma with tumor invading bladder or rectum. M0: No distant metastasis. (from AJCC 8th Ed.)


Mixed Tumor, Not Otherwise Specified

description: A benign myoepithelioma characterized by the presence of a minor ductal component.


name: Vulvar Composite Hidradenoma Papilliferum and Fibroadenoma

description: A benign composite neoplasm that arises from the vulva and is characterized by mixed histopathologic features of hidradenoma papilliferum and fibroadenoma.


name: Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor

description: A malignant non-seminomatous germ cell tumor arising from the testis.  It is characterized by a mixture of embryonal carcinoma and yolk sac morphologic elements.  Patients may present with painless or painful testicular swelling.


name: Pancreatic Mixed Acinar-Ductal Neuroendocrine Carcinoma

description: A very rare carcinoma that arises from the pancreas and is composed of ductal adenocarcinoma, acinar carcinoma, and neuroendocrine carcinoma components.


Trichoblastic carcinosarcoma

description: A rare biphasic follicular neoplasm consisting of a malignant epithelial component resembling follicular germinative cells closely associated with a malignant stromal component differentiating towards specific follicular mesenchyme. (WHO 2018)


name: Metastatic Digestive System Mixed Adenoneuroendocrine Carcinoma

description: Mixed adenoneuroendocrine carcinoma that arises from the digestive system and has metastasized to other anatomic sites.


Hybrid nerve sheath tumor

description: A benign nerve sheath tumor characterized by the combination of histologic features seen in schwannomas, neurofibromas, and perineuriomas.


Pleomorphic adenoma of lacrimal gland

description: A benign, usually encapsulated neoplasm of the lacrimal gland composed of epithelial and mesenchymal cells.  Pleomorphic adenomas are neoplasms that develop in the salivary glands or heterotopic salivary gland tissues.  It has been suggested that myoepithelial cells play a major role in the histogenesis of these tumors.  In the lacrimal gland, pleomorphic adenomas presumably develop from metaplastic myoepithelial cells.