Leukemia, Myeloid, Chronic-Phase

description: A phase of chronic myeloid leukemia, BCR-ABL1 positive in which the peripheral blood smear shows leukocytosis with neutrophils in different stages of maturation, less than 2% blasts, and normal or increased platelet count. Most patients have mild anemia. The bone marrow is hypercellular due to increased numbers of neutrophils and their precursors, and blasts usually account for fewer than 5% of the marrow cells. Megakaryocytes are smaller than normal and have hypolobated nuclei. The spleen is enlarged due to infiltration of the cords of the red pulp by granulocytes.


Abnormal granulation tissue

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


regulation of tooth mineralization

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.


beta-galactosidase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.


bombesin receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: establishment of body hair or bristle planar orientation

description: Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project.


activin responsive factor complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.


name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.


description: The series of molecular signals initiated by interleukin-4 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


ductus arteriosus closure

description: The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.


nuclear lamina

description: The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.


Eye Injuries, Penetrating

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


dentin sensitivity

description: Pain or discomfort caused by exposure of the dentin layer of tooth to thermal, tactile, or other stimuli.


amide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.


beta-alanine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.


flap endonuclease activity

description: Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.


regulation of eosinophil migration

description: Any process that modulates the frequency, rate or extent of eosinophil migration.


name: cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

description: Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.


geographic tongue

description: A benign condition characterized by the development of irregular patches in the surface of the tongue resulting in a map-like appearance. The patches migrate from day to day and usually resolve without treatment.


regulation of endocytic recycling

description: Any process that modulates the frequency, rate or extent of endocytic recycling.


interleukin-27 receptor activity

description: Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: positive regulation of melanin biosynthetic process

description: Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.


tryptophan-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).


name: positive regulation of interleukin-3 production

description: Any process that activates or increases the frequency, rate, or extent of interleukin-3 production.


retinal perforation

description: A usually small tearing of the retina occurring when the vitreous separates from the retina. It may lead to retinal detachment. Symptoms include flashes and floaters.


Aspiration

description: Inspiration of a foreign object into the airway.


microfibril binding

description: Binding to a microfibril, any small fibril occurring in biological material.


marginal zone B cell differentiation

description: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).


glucosylceramidase activity

description: Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.


regulation of neutrophil extravasation

description: Any process that modulates the frequency, rate or extent of neutrophil extravasation.


name: long-chain fatty acid import into peroxisome

description: The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: negative regulation of macrophage colony-stimulating factor signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway.


name: negative regulation of type B pancreatic cell development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development.


name: tRNA (adenine) methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine.


Lesion of cervix

description: A localized pathological or traumatic structural change, damage, deformity, or discontinuity of the cervix uteri.


Malignant Solid Neoplasm

description: A malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include carcinomas and sarcomas. Hematopoietic and lymphoid tissue malignancies are not considered solid neoplasms.


dibenzo-p-dioxin metabolic process

description: The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern.


name: B cell proliferation involved in immune response

description: The expansion of a B cell population by cell division following B cell activation during an immune response.


skeleton

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.


name: positive regulation of eosinophil migration

description: Any process that activates or increases the frequency, rate or extent of eosinophil migration.


nitroxoline

A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.


name: regulation of peptidyl-cysteine S-nitrosylation

description: Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


name: regulation of smooth muscle cell-matrix adhesion

description: Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion.


name: negative regulation of mRNA catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process.


corpus luteum cyst

description: A ovarian cyst (disease) that involves the corpus luteum.


name: positive regulation of vitamin D 24-hydroxylase activity

description: Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D.


CHOP-C/EBP complex

description: A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors.


sno(s)RNA metabolic process

description: The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA.


Dyschromatopsia

description: A form of colorblindness in which only two of the three fundamental colors can be distinguished due to a lack of one of the retinal cone pigments.


mitotic cohesin complex

description: A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.


endothelin receptor activity

description: Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


response to symbiotic bacterium

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.


fucosidase activity

description: Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative.


mononeuritis simplex

description: Neuritis of a single nerve.


Hyperchloremia

description: An abnormally increased chloride concentration in the blood.


gastric acid secretion

description: The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


D2 dopamine receptor binding

description: Binding to a D2 dopamine receptor.


endomyocardial fibrosis

description: A disease characterized by fibrotic thickening of the endocardium, particularly the right and/or left inflow tracts. The disease often involves the atrioventricular valves, leading to valvular regurgitaion. It most commonly occurs in children living within 15 degrees of the equator.


name: negative regulation of relaxation of cardiac muscle

description: Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle.


Multiple lentigines

description: Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots.


diapedesis

description: The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.


response to hydroxyurea

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.


lymphangioleiomyomatosis

description: A multifocal neoplasm with perivascular epithelioid cell differentiation affecting almost exclusively females of child-bearing age. It is characterized by the presence of smooth muscle and epithelioid cells and by the proliferation of lymphatic vessels. Sites of involvement include the lungs, mediastinum, and the retroperitoneum. It usually presents with chylous pleural effusion or ascites.


terminal cisterna

description: The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release.


maxillary sinus

description: One of the paired paranasal sinuses, located in the body of the maxilla, communicating with the middle meatus of the nasal cavity.


regulation of grooming behavior

description: Any process that modulates the frequency, rate or extent of grooming behavior.


Rab GDP-dissociation inhibitor activity

description: Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.


regulation of microvillus length

description: A process that modulates the length of a microvillus.


name: regulation of mitochondrial electron transport, NADH to ubiquinone

description: Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.


dynein complex binding

description: Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.


name: external encapsulating structure organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.


name: histone H3K27me2/H3K27me3 demethylase activity

description: Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


thiamine transport

description: The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.


name: cholesterol biosynthetic process via desmosterol

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol.


cellular response to muramyl dipeptide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.


podosome assembly

description: The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell.


calcitonin family receptor activity

description: Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity.


Limb muscle weakness

description: Reduced strength and weakness of the muscles of the arms and legs.


gamma-glutamylcyclotransferase activity

description: Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.


complex regional pain syndrome type 2

description: Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia, not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area.


Mask-like facies

description: A lack of facial expression often with staring eyes and a slightly open mouth.


Elevated jugular venous pressure

description: Increased jugular venous pressure.


U6 snRNA binding

description: Binding to a U6 small nuclear RNA (U6 snRNA).


name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

description: All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.


name: isopentenyl diphosphate biosynthetic process, mevalonate pathway

description: The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.


ureter morphogenesis

description: The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder.


name: regulation of metanephric glomerular mesangial cell proliferation

description: Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation.


Pneumoperitoneum

description: Free air within the peritoneal cavity.


vestibulocochlear nerve formation

description: The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.


galactosylceramide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.


name: negative regulation of calcium ion binding

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding.


name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

description: Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP.


central nervous system segmentation

description: Division of the central nervous system into a series of semi-repetitive parts or segments.


name: glutathione disulfide oxidoreductase activity

description: Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.


Tooth Fractures

description: Broken tooth affecting any portion of tooth: root fracture, crown-root, broken tooth (crown fracture), chipped tooth. A crown fracture can involve the pulp. Tooth fracture sequelae range in severity from cosmetic defects to tooth death. Involvement of the pulp is a more important indicator of severity of tooth fracture than is the amount of the tooth affected.


soft palate

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The muscular, non-bony arch-shaped posterior portion of the palate extending from the posterior edge of the hard palate.


MHC class I protein complex binding

description: Binding to a class I major histocompatibility complex.


frontal suture morphogenesis

description: The process in which the frontal suture is generated and organized.


name: negative regulation of exo-alpha-sialidase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity.


periciliary membrane compartment

description: A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.


hair follicle placode formation

description: The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


male pronucleus assembly

description: The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division.


name: thorax and anterior abdomen determination

description: Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.


name: establishment of cell polarity involved in ameboidal cell migration

description: The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.


name: positive regulation of metanephric mesenchymal cell migration

description: Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration.


pyrimidine ribonucleotide binding

description: Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


sterol O-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.


Venous occlusion

description: Blockage of venous return (flow of blood from the periphery back towards the right atrium) in a vein.


response to genistein

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.


chlamydia infectious disease

description: Infections with bacteria of the genus CHLAMYDIA.


DNA topoisomerase binding

description: Binding to a DNA topoisomerase.


hepatic immune response

description: An immune response taking place in the liver.


tinea corporis

description: A dermatophyte disease of the glabrous skin, excluding the scalp, beard, face, hands, feet, and groin.


acute cystitis

description: An acute infection of the bladder. It is usually caused by bacteria. Signs and symptoms include increased frequency of urination, pain or burning during urination, fever, cloudy or bloody urine, and suprapubic pain.


plasma cell differentiation

description: The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.


dolichol metabolic process

description: The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.


response to bile acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.


purine nucleotide salvage

description: Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis.


name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development.


name: ATP-activated inward rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.


name: negative regulation of mitochondrial membrane potential

description: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


name: positive regulation of plasminogen activation

description: Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.


name: regulation of synaptic vesicle endocytosis

description: Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.


name: regulation of neurofibrillary tangle assembly

description: Any process that modulates the frequency, rate or extent of neurofibrillary tangle assembly.


name: regulation of cellular response to X-ray

description: Any process that modulates the frequency, rate or extent of cellular response to X-ray.


fasciculation of sensory neuron axon

description: The collection of sensory neuron axons into a bundle of rods, known as a fascicle.


type 5 melanocortin receptor binding

description: Binding to a type 5 melanocortin receptor.


bacterial vaginosis

description: Infection caused by bacterial overgrowth in the vagina. Most affected women are asymptomatic. When symptoms occur, they include foul-smelling vaginal discharge, vaginal itching, and burning. Risk factors include sexual activity with multiple partners and the use of vaginal douches and intrauterine devices. Up to a third of cases resolve without treatment. Antibiotic treatment is recommended when symptoms are present and for women that are pregnant at the time of infection.


name: positive regulation of transcription elongation by RNA polymerase II

description: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


name: potassium ion export across plasma membrane

description: The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.


name: positive regulation of T cell tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.


pilomotor reflex

description: The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect.


name: negative regulation of mitochondrial DNA replication

description: Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.


interneuron migration

description: The orderly movement of an interneuron from one site to another.


name: chromosome localization to nuclear envelope involved in homologous chromosome segregation

description: The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.


name: positive regulation of luteinizing hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone.


name: negative regulation of gene expression via chromosomal CpG island methylation

description: An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes.


Spemann organizer formation

description: Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan.


name: negative regulation of miRNA transcription

description: Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription.


malignant histiocytosis

description: Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of macrophages and dendritic cells.


rDNA heterochromatin

description: A region of heterochromatin located at the rDNA repeats in a chromosome.


cellular heat acclimation

description: Any process that increases heat tolerance of a cell in response to high temperatures.


peripheral arterial disease

description: A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest.


nickel cation binding

description: Binding to a nickel (Ni) cation.


name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration

description: The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.


negative regulation of bone development

description: Any process that stops, prevents or reduces the frequency, rate or extent of bone development.


name: cellular response to mineralocorticoid stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance.


taste receptor complex

description: A protein complex which is capable of taste receptor activity.


courtship behavior

description: The behavior of an organism for the purpose of attracting sexual partners.


breast cyst

description: A cystic lesion located in breast tissue.


name: pyrimidine nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.


name: positive regulation of type B pancreatic cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.


name: serotonin secretion involved in inflammatory response

description: The regulated release of serotonin by a cell as part of an inflammatory response.


bacterial meningitis

description: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.


CA3 pyramidal cell dendrite

description: A dendrite of a hippocampal CA3 pyramidal cell.


name: positive regulation of gastric acid secretion

description: Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


name: tRNA transcription by RNA polymerase III

description: The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.


regulation of muscle atrophy

description: Any process that modulates the frequency, rate or extent of muscle atrophy.


membrane raft localization

description: Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


circadian rhythm sleep disorder

description: A persistent or recurrent pattern of sleep disruption that is primarily due to an alteration of the circadian system or to a misalignment between the endogenous circadian rhythm and the sleep-wake schedule required by an individual's physical environment or social or professional schedule.(DSM IV)


description: Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.


ERBB2 signaling pathway

description: The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.


ichthyosis prematurity syndrome

description: Ichthyosis prematurity syndrome is a rare, syndromic congenital ichthyosis characterized by premature birth (at gestational weeks 30-32, in general) in addition to thick, caseous and desquamating epidermis, neonatal respiratory asphyxia, and persistent eosinophilia. After the perinatal period, a spontaneous improvement in the health of affected patients is observed and skin features (vernix caseosa-like scale) evolve into a mild presentation of flat follicular hyperkeratosis with atopy.


name: negative regulation of multicellular organism growth

description: Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.


name: positive regulation of platelet activation

description: Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.


fatty-acyl-CoA synthase activity

description: Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.


name: positive regulation of T cell extravasation

description: Any process that activates or increases the frequency, rate or extent of T cell extravasation.


name: positive regulation of T-helper 2 cell cytokine production

description: Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.


hepatocellular adenoma

description: A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears as a soft, round mass which often contains areas of hemorrhage and necrosis. Morphologically, the neoplastic cells resemble normal hepatocytes and form plates separated by sinusoids. Most patients have a history of contraceptive or anabolic steroids use.


central nervous system maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.


name: negative regulation of nucleobase-containing compound transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of DNA damage response, signal transduction by p53 class mediator

description: Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.


poliomyelitis

description: An acute infectious disorder that affects the nervous system. It is caused by the poliovirus. The virus spreads by direct contact, and can be prevented by prophylaxis with the polio vaccine.


interleukin-2 receptor activity

description: Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


radiation myelitis

description: A disease characterized by white matter damage to the spinal cord developed after a certain period of application of ionizing radiation.


response to chlorate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus.


bile acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.


name: glomerular parietal epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


name: negative regulation of excitatory postsynaptic potential

description: Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


name: negative regulation of lamellipodium morphogenesis

description: Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis.


name: inner medullary collecting duct development

description: The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla.


name: negative regulation of uterine smooth muscle contraction

description: Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction.


microspike

description: A dynamic, actin-rich projection extending from the surface of a migrating animal cell.


name: membrane protein proteolysis involved in retrograde protein transport, ER to cytosol

description: Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol.


mannosamine metabolic process

description: The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins.


type 3 galanin receptor binding

description: Binding to a type 3 galanin receptor.


name: response to human chorionic gonadotropin

description: Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.


name: negative regulation of response to type II interferon

description: Any process that decreases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus.


type B pancreatic cell maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.


snRNA export from nucleus

description: The directed movement of snRNA from the nucleus to the cytoplasm.


name: positive regulation of immune complex clearance by monocytes and macrophages

description: Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.


reproductive system disorder

description: A disease involving the reproductive system.


AMP transmembrane transporter activity

description: Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other.


name: Infection by Pneumocystis jirovecii (disorder)


name: meiotic DNA double-strand break formation

description: The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.


UDP-glucuronate metabolic process

description: The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.


name: regulation of high-density lipoprotein particle clearance

description: Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


kidney neoplasm

description: A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma.


name: positive regulation of fibroblast growth factor production

description: Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


Hypervigilance

description: A heightened alertness is characterized by a broad awareness and/or excessive scanning of environmental stimuli.


ASAP complex

description: A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.


four-way junction helicase activity

description: Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.


name: regulation of complement activation, lectin pathway

description: Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.


ATP transport

description: The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


multivesicular body, internal vesicle

description: A membrane-bounded vesicle wholly contained within a multivesicular body.


polyarticular arthritis

description: An arthritis affecting five or more separate joints.


staphylococcal scalded skin syndrome

description: A blistering skin disorder caused by exfoliative toxins produced by Staphylococcus aureus infection. The toxins cause the formation of bullae and diffuse skin desquamation. The lesions may be localized or generalized, far away from the initial site of infection.


name: glutamate:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).


name: metaphase/anaphase transition of cell cycle

description: The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle.


name: negative regulation of smooth muscle cell-matrix adhesion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion.


rosoxacin

A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by an ethyl group at position 1 and by a pyridin-4-yl group at position 7. An antibacterial drug, active against Neisseria gonorrhoeae, it has been used for treating urinary tract infections and certain sexually transmitted diseases.


description: Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.


natural killer cell chemotaxis

description: The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


name: positive regulation of vacuolar transport

description: Any process that activates or increases the frequency, rate or extent of vacuolar transport.


name: negative regulation of maintenance of mitotic sister chromatid cohesion

description: Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle.


follicular dendritic cell activation

description: A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.


name: positive regulation of the force of heart contraction

description: Any process that increases the force of heart muscle contraction.


SUMO activating enzyme complex

description: A conserved heterodimeric complex with SUMO activating enzyme activity.


Thyroid nodule

description: A nodular lesion that develops in the thyroid gland. The term "thyroid nodule" refers to any abnormal growth that forms a lump in the thyroid gland.


L-cysteine metabolic process

description: The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.


cilium-dependent cell motility

description: Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.


name: regulation of neurotrophin TRK receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.


name: respiratory burst involved in defense response

description: A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.


name: follicular dendritic cell differentiation

description: The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.


olfactory learning

description: Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.


vasopressin secretion

description: The regulated release of vasopressin from secretory granules into the blood.


olfactory placode formation

description: The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.


name: negative regulation of meiotic cell cycle phase transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition.


name: negative regulation of skeletal muscle cell proliferation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.


eating disorder

description: A broad group of psychological disorders with abnormal eating behaviors leading to physiological effects from overeating or insufficient food intake.


name: glomerular mesangial cell differentiation

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state.


sheath of Schwann

description: The outermost nucleated cytoplasmic layer of Schwann cells that surrounds the axon of the neuron. It forms the outermost layer of the nerve fiber in the peripheral nervous system. The neurolemma is underlain by the basal lamina (referred to as the medullary sheath in the included illustrations. In CNS, axons are myelinated by oligodendrocytes, thus lack neurolemma.


6-phosphofructokinase activity

description: Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.


lipoprotein lipase activator activity

description: Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.


Lipedema

description: Disorder of adipose tissue characterized by symmetric and bilateral enlargement of the lower extremities due to abnormal deposition of subcutaneous fat often in obese women. It is associated with hematoma, pain and may progress to secondary lymphedema which is known as lipolymphedema.


germinal center B cell differentiation

description: The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).


actomyosin contractile ring

description: A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.


regulation of mitophagy

description: Any process that modulates the frequency, rate or extent of macromitophagy.


name: cholesterol biosynthetic process via lathosterol

description: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol.


endoplasmic reticulum mannose trimming

description: Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC).


name: negative regulation of mesoderm development

description: Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.


benign vaginal neoplasm

description: A non-metastasizing neoplasm that arises from the vagina. Representative examples include squamous papilloma and melanocytic nevus.


name: positive regulation of postsynaptic membrane organization

description: Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization.


name: positive regulation of timing of catagen

description: Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


CD40 receptor binding

description: Binding to CD40, a receptor found on the surface of all B-lymphocytes.


Klebsiella pneumonia

description: An pneumonia caused by infection with Klebsiella.


central nervous system malformation

description: An abnormality of the nervous system.


name: regulation of NLRP3 inflammasome complex assembly

description: Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly.


name: negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

description: Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.


name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

description: Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.


Chronic constipation

description: Constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard stools, and a sensation of anorectal obstruction or incomplete defecation.


NK T cell proliferation

description: The expansion of a NK T cell population by cell division.


lung lymphoma

description: A rare non-Hodgkin or Hodgkin lymphoma that arises in and is confined to the lung at the time of diagnosis.


cold acclimation

description: Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.


ovarian neoplasm

description: A benign, borderline, or malignant neoplasm involving the ovary.


name: ABC-type peptide antigen transporter activity

description: Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate.


name: calcium-independent phospholipase A2 activity

description: Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.


fructose catabolic process

description: The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose.


Fractured ankle

description: A fracture or multiple fractures of one or more of three bones in the ankle joint: the tibia (shinbone), the fibula (outer ankle bone), and the talus (which is the bone that connects your leg to your foot).


beta-N-acetylhexosaminidase activity

description: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.


name: potassium:chloride symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).


Rho GDP-dissociation inhibitor binding

description: Binding to a Rho GDP-dissociation inhibitor protein.


Chemical Burns

description: A burn caused by exposure to chemical substances.


His bundle tachycardia

description: His bundle tachycardia is a very rare congenital genetic tachyarrhythmia characterized by incessant tachycardia and high morbidity and mortality.


cytosine metabolic process

description: The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.


regulation of mRNA binding

description: Any process that modulates the frequency, rate or extent of mRNA binding.


acute intermittent porphyria

description: Acute intermittent porphyria is the most frequent and the most severe form of the acute hepatic porphyrias. It is characterized by the occurrence of neuro-visceral attacks without cutaneous manifestations.


Shc-EGFR complex

description: A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.


name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

description: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.


Rad51C-XRCC3 complex

description: A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.


osteochondrosis

description: A condition that is characterized by defective bone growth that affects the growth centers of bone.


name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


Bilateral Deafness

description: Partial or total inability to hear sounds in both ears.


phytoalexin metabolic process

description: The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response.


aspartate carbamoyltransferase activity

description: Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.


Noc complex

description: Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis.


response to luteinizing hormone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus.


name: positive regulation of membrane tubulation

description: Any process that activates or increases the frequency, rate or extent of membrane tubulation.


name: Trichomonas vaginitis urogenital infection

description: A sexually transmitted parasitic infection caused by Trichomonas vaginalis. Symptoms include vaginal discharge, vaginal odor, vaginal itching, and discomfort during intercourse.


T cell receptor V(D)J recombination

description: The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


name: positive regulation of nuclear cell cycle DNA replication

description: Any process that activates or increases the frequency, rate or extent of the DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.


epinephrine binding

description: Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.


negative regulation of vesicle fusion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.


name: negative regulation of female gonad development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.


inflammatory cell apoptotic process

description: Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.


spermine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.


sequestering of zinc ion

description: The process of binding or confining zinc ions such that they are separated from other components of a biological system.


name: vasculogenesis involved in coronary vascular morphogenesis

description: The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.


name: Retained placenta and membranes (disorder)


name: regulation of Notch signaling pathway involved in somitogenesis

description: Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis.


name: Gonadotropic luteinizing hormone increased


name: acetate ester transmembrane transporter activity

description: Enables the transfer of an acetate ester from one side of a membrane to the other.


compound eye development

description: The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.


apelin receptor binding

description: Binding to an apelin receptor.


name: regulation of glucose catabolic process to lactate via pyruvate

description: Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.


nitrobenzene metabolic process

description: The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline.


name: leukemia inhibitory factor receptor activity

description: Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: mismatch base pair DNA N-glycosylase activity

description: Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.


description: Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.


name: negative regulation of skeletal muscle satellite cell proliferation

description: Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation.


protein phosphatase 4 complex

description: A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.


name: positive regulation of telomeric DNA binding

description: Any process that activates or increases the frequency, rate or extent of telomeric DNA binding.


DNA replication factor C complex

description: A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.


description: Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.


integrin alpha3-beta1 complex

description: An integrin complex that comprises one alpha3 subunit and one beta1 subunit.


meiotic spindle assembly

description: The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.


skeletal muscle cell proliferation

description: The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.


acute graft versus host disease

description: A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and GI tract. The onset is usually within one hundred days of transplantation or immunologic manipulation.


name: regulation of serine C-palmitoyltransferase activity

description: Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity.


name: camera-type eye photoreceptor cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye.


eye photoreceptor cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.


monoclonal gammopathy

description: A condition characterized by the abnormal presence of monoclonal immunoglobulins in the blood or urine.


U7 snRNP

description: A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs.


name: positive regulation of t-circle formation

description: Any process that activates or increases the frequency, rate or extent of t-circle formation.


cerumen

description: The yellow or brown waxy secretions produced by vestigial apocrine sweat glands in the external ear canal[MESH].


name: endoplasmic reticulum membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane.


alpha-1,3-mannosyltransferase activity

description: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.


vascular malformation

description: A non-neoplastic disorder that is the result of defects of vascular morphogenesis.


Complete Hearing Loss

description: Total inability to hear sounds in one or both ears.


name: negative regulation of apoptotic process involved in metanephric nephron tubule development

description: Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development.


name: positive regulation of peptidyl-cysteine S-nitrosylation

description: Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.


global gene silencing by mRNA cleavage

description: A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner.


regulation of collagen binding

description: Any process that modulates the frequency, rate or extent of collagen binding.


exosomal secretion

description: The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.


mesangial cell-matrix adhesion

description: The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney.


mitotic centrosome separation

description: Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


Ketonuria

description: High levels of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the urine. Ketone bodies are insignificant in the blood and urine of normal individuals in the postprandial or overnight-fasted state.


Oculorespiratory syndrome

description: A transient condition that can occur following influenza vaccination that is characterized by bilateral conjunctivitis, facial edema, and upper respiratory symptoms.


name: regulation of skeletal muscle contraction by calcium ion signaling

description: Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction.


name: regulation of non-motile cilium assembly

description: Any process that modulates the frequency, rate or extent of non-motile cilium assembly.


constitutive secretory pathway

description: A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space.


name: spermine:oxygen oxidoreductase (spermidine-forming) activity

description: Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine.


name: negative regulation of T-helper 2 cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.


Scrotal pain

description: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the scrotum.


name: regulation of cap-independent translational initiation

description: Any process that modulates the frequency, rate or extent of cap-independent translational initiation.


name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the adenylate cyclase-activating adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands.


polyp of rectum

description: A polyp that involves the rectum.


valyl-tRNA aminoacylation

description: The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.


Epstein-Barr virus infection

description: An infection that is caused by Epstein-Barr virus.


name: positive regulation of calcium:sodium antiporter activity

description: Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity.


Coombs Test Positive

description: A laboratory test result demonstrating the presence of antibodies that act against red blood cells.


name: L-histidine catabolic process to glutamate and formamide

description: The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide.


serotonin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.


circadian temperature homeostasis

description: Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.


SUMO-targeted ubiquitin ligase complex

description: A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes.


name: clathrin-sculpted monoamine transport vesicle

description: A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines.


name: transforming growth factor beta receptor activity, type I

description: Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.


name: His-Purkinje system cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.


pyloric stenosis

description: Narrowing of the pyloric lumen caused either by hypertrophy of the surrounding muscles or tissue scarring due to a chronic peptic ulcer.


name: positive regulation of tooth mineralization

description: Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.


DNA replication, synthesis of primer

description: The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer.


galanin receptor binding

description: Binding to a galanin receptor.


Corneal Abrasions

description: Injury to the epithelium of the cornea.


AIM2 inflammasome complex

description: An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.


embryonic brain development

description: The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.


response to sodium phosphate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus.


response to sodium arsenite

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus.


name: positive regulation of antimicrobial peptide production

description: Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.


name: positive regulation of DNA endoreduplication

description: Any process that activates or increases the frequency, rate or extent of DNA endoreduplication.


name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


QT interval feature (observable entity)

category: biolink:ClinicalAttribute biolink:Attribute biolink:OntologyClass biolink:NamedThing


hepatosplenic T-cell lymphoma

description: An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic T-cells, usually of gamma/delta T-cell type. It is characterized by the presence of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A similar infiltrating pattern is also present in the spleen and bone marrow that are usually involved at the time of the diagnosis.


nucleotide-sugar catabolic process

description: The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.


Peripheral Nerve Injuries

description: Sensory or motor loss of peripheral nerve function due to a traumatic event. (ACC)


name: striatal medium spiny neuron differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.


nuclear pore nuclear basket

description: A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.


vitamin E binding

description: Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.


cellular response to oleic acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus.


cellular response to bile acid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.


name: positive regulation of amyloid precursor protein biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.


name: mitochondrial proton-transporting ATP synthase complex assembly

description: The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane.


vacuolar protein processing

description: Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.


name: medium-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.


anaphase-promoting complex binding

description: Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.


vitamin D receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by vitamin D binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: double-strand break repair via single-strand annealing

description: Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.


name: positive regulation of endothelial cell development

description: Any process that activates or increases the frequency, rate or extent of endothelial cell development.


L-glutamine aminotransferase activity

description: Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid.


name: Pwp2p-containing subcomplex of 90S preribosome

description: A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.


name: negative regulation of amyloid precursor protein biosynthetic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.


rhombomere 2 development

description: The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.


Pulmonary Alveolar Hemorrhage

description: Bleeding in the alveoli.


Fracture of pelvis

description: A traumatic break in one or more of the bones that compose the bony structure of the pelvis.


response to interleukin-11

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus.


Infectious Enterocolitis

description: An infectious process affecting the small and large intestines. Symptoms include diarrhea, cramping abdominal pain, and fever.


complex regional pain syndrome

description: Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.


translation release factor complex

description: A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.


tricuspid valve

description: An atrioventricular valve that is part of the outflow part of the right atrium.


pyridoxal

A pyridinecarbaldehyde that is pyridine-4-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 5 respectively. The 4-carboxyaldehyde form of vitamin B6, it is converted into pyridoxal phosphate, a coenzyme for the synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.


integrin alpha1-beta1 complex

description: An integrin complex that comprises one alpha1 subunit and one beta1 subunit.


Cdc42 protein signal transduction

description: An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal.


name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

description: Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


cellular response to anoxia

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.


regulation of osteoclast proliferation

description: Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.


Bacterial prostatitis

description: An acute or chronic bacterial infection that affects the prostate gland.


alpha-beta T cell lineage commitment

description: The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.


name: Mo-molybdopterin cofactor biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.


name: positive regulation of necroptotic process

description: Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.


name: regulation of neutrophil differentiation

description: Any process that modulates the frequency, rate or extent of neutrophil differentiation.


lipoxin biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid.


Lymphocytosis

description: A finding indicating the presence of a non-neoplastic or neoplastic proliferation of lymphocytes in the peripheral blood, effusions, or bone marrow.


response to glucoside

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus.


zona reticularis of adrenal gland

description: The inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids.


Athletic Injuries

description: An injury sustained while practicing or competing in a sport.


response to nickel cation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus.


name: inositol bisdiphosphate tetrakisphosphate diphosphatase activity

description: Catalysis of the reaction: bisdiphospho-1D-myo-inositol tetrakisphosphate + H2O = diphospho-1D-myo-inositol pentakisphosphate + phosphate.


name: polyamine transmembrane transporter activity

description: Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other.


mitochondrial tRNA methylation

description: The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.


name: regulation of T cell homeostatic proliferation

description: Any process that modulates the frequency, rate or extent of resting T cell proliferation.


carcinoid tumor

description: A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement.


name: transforming growth factor beta receptor complex assembly

description: The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.


B cell negative selection

description: Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.


Low-set ears

description: Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear.


name: positive regulation of skeletal muscle acetylcholine-gated channel clustering

description: Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.


spina bifida occulta

description: The mildest form of spina bifida, characterized by any of several neural tube defects which may go undetected until an x-ray is performed. Treatment is symptomatic.


name: inositol tetrakisphosphate phosphatase activity

description: Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate.


Postoperative Hypertension

description: A transient increase in blood pressure following a surgical procedure.


name: positive regulation of hepatic stellate cell activation

description: Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.


ureteric bud invasion

description: The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros.


omphalocele

description: Omphalocele is an embryopathy classified in the group of abdominal celosomias and is characterized by a large hernia of the abdominal wall, centered on the umbilical cord, in which the protruding viscera are protected by a sac.


NF-kappaB complex

description: A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.


name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.


Poor R Wave Progression by ECG Finding

description: An electrocardiographic finding of a lack of progression of R wave height across precordial leads. (CDISC)


name: positive regulation of smooth muscle cell chemotaxis

description: Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.


name: negative regulation of forebrain neuron differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.


leading strand elongation

description: The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork.


photoreceptor inner segment membrane

description: The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.


name: positive regulation of isomerase activity

description: Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.


name: refractory anemia with excess blasts in transformation

description: Refractory anemia with excess blasts in transformation (RAEB-T) is characterized by dysplastic features of the myeloid and usually erythroid progenitor cells in the bone marrow and an increased number of myeloblasts in the peripheral blood. The peripheral blood blast count ranges from 20% to 30%. RAEB-T used to be a subcategory of myelodysplastic syndromes in the past. Recently, the term has been eliminated from the WHO based classification of myelodysplastic syndromes. The reason is that the percentage of peripheral blood blasts required for the diagnosis of acute myeloid leukemia has been reduced to 20%. The elimination of the RAEB-T term by the WHO experts has created confusion and ongoing arguments. Currently, according to WHO classification, the vast majority of RAEB-T cases are best classified as acute leukemias (acute leukemias with multilineage dysplasia following myelodysplastic syndrome). A minority of cases are part of RAEB-2.


Wernicke-Korsakoff syndrome

description: Wernicke-Korsakoff syndrome is a brain disorder, due to thiamine deficiency that has been associated with both Wernicke's encephalopathy and Korsakoff syndrome. The term refers to two different syndromes, each representing a different stage of the disease. Wernicke's encephalopathy represents the 'acute' phase and Korsakoff's syndrome represents the 'chronic' phase. However, they are used interchangeable in many sites. Wernicke's encephalopathy is characterized by confusion, abnormal stance and gait (ataxia), and abnormal eye movements (nystagmus). Korsakoff's syndrome is observed in a small number of patients. It is a type of dementia, characterized by memory loss and confabulation (filling in of memory gaps with data the patient can readily recall) and involvement of the heart, vascular, and nervous system. Wernicke-Korsakoff syndrome mainly results from chronic alcohol use, but also from dietary deficiencies, prolonged vomiting, eating disorders, systemic diseases (cancer, AIDS, infections), bariatric surgery, transplants, or the effects of chemotherapy. Studies indicate that there may be some genetic predisposition for the disease.Treatment involves supplementing the diet with thiamine. Wernicke encephalopathy is an acute syndrome and requires emergency treatment to prevent death and neurologic complications. In cases where the diagnosis is not confirmed, patients should still be treated while additional evaluations are completed.


name: negative regulation of gonadotropin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin.


name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

description: Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.


Central line infection

description: An infectious process related to a central venous catheter.


name: dermatophytosis of groin and perianal area

description: Dermatophytosis involving the stratum corneum of the skin of the groin and perianal area.


podocyte development

description: The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells.


name: extrinsic component of mitochondrial outer membrane

description: The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


chronic pyelonephritis

description: Persistent pyelonephritis.


name: peptidyl-lysine modification to peptidyl-hypusine

description: The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.


trachea formation

description: The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.