negative regulation of heart rate

description: Any process that stops, prevents or reduces the frequency or rate of heart contraction.


acquired Fanconi syndrome

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Fanconi Syndrome caused by exposure to noxious agents.


name: regulation of sulfur amino acid metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.


Guillain-Barre syndrome

description: A spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients. GBS is clinically heterogeneous and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS) and some other regional variants.


Upper airway obstruction

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Increased resistance to the passage of air in the upper airway.


name: positive regulation of brown fat cell differentiation

description: Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.


name: adenylate cyclase-inhibiting dopamine receptor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor, and ending with the regulation of a downstream cellular process.


name: regulation of protein heterodimerization activity

description: Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.


name: positive regulation of neurotransmitter uptake

description: Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.


name: crossover junction DNA endonuclease activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).


name: type II transforming growth factor beta receptor binding

description: Binding to a type II transforming growth factor beta receptor.


name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process.


name: negative regulation of proteasomal protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.


pia mater

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The innermost layer of the leptomeninges, consisting of a delicate membrane closely covering the surface of the brain and spinal cord,and lying under the arachnoid membrane. The pia, unlike the arachnoid, extends into the sulci in gyrencephalic animals.


Vascular resistance

category: biolink:PhysiologicalProcess biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: immunoglobulin transcytosis in epithelial cells

description: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.


yohimbine

An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.


opsonin receptor activity

description: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: L-glutamate transmembrane transporter activity

description: Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.


Gangrene

description: A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).


actinic keratosis

description: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.


name: cell fate commitment involved in pattern specification

description: The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.


aldehyde catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.


name: negative regulation of blood vessel endothelial cell migration

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.


insulin metabolic process

description: The chemical reactions and pathways involving insulin.


retinol binding

description: Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.


interleukin-8 production

description: The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


pyrimidine nucleoside catabolic process

description: The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


name: tRNA-type intron splice site recognition and cleavage

description: RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.


arachnoiditis

description: Arachnoiditis (ARC) is a chronic inflammation of the arachnoid layer of the meninges, of which adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems.


colon carcinoma

description: A carcinoma that arises from epithelial cells of the colon


fungiform papilla development

description: The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue.


name: melanocyte-stimulating hormone receptor activity

description: Combining with melanocyte-stimulating hormone to initiate a change in cell activity.


name: porphyrin-containing compound catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.


CAAX-box protein maturation

description: A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase.


endothelial cell proliferation

description: The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.


Hepatosplenomegaly

description: Simultaneous enlargement of the liver and spleen.


description: A disorder characterized by an enduring pattern of inflexibility, extreme orderliness, and perfectionism which interfere with efficiency and which may manifest in many different contexts, including work and leisure activities, financial matters, and issues of morality or ethics.


Edema of the upper limbs

description: An abnormal accumulation of fluid beneath the skin of the arms.


alcohol dehydrogenase (NADP+) activity

description: Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.


hemoglobin complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group.


name: epithelial cell proliferation involved in salivary gland morphogenesis

description: The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland.


cellular response to alkaloid

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.


synaptonemal complex assembly

description: The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination.


name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound.


DEAD/H-box RNA helicase binding

description: Binding to a DEAD/H-box RNA helicase.


C-terminal protein deglutamylation

description: The removal of a C-terminal, gene-encoded glutamate residue from a protein.


regulation of glomerulus development

description: Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


trochlear nerve development

description: The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.


eosinophil mediated immunity

description: Any process involved in the carrying out of an immune response by an eosinophil.


volume-sensitive anion channel activity

description: Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.


collagen type IV trimer

description: A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.


type II interferon production

description: The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.


serine binding

description: Binding to 2-amino-3-hydroxypropanoic acid.


heart trabecula formation

description: The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.


name: extracellular matrix constituent conferring elasticity

description: A component of the extracellular matrix that enables the matrix to recoil after transient stretching.


response to mycophenolic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus.


name: regulation of activation-induced cell death of T cells

description: Any process that modulates the occurrence or rate of activation-induced cell death of T cells.


cellular response to hyperoxia

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.


name: negative regulation of nervous system process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.


POZ domain binding

description: Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.


positive regulation of ovulation

description: Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.


name: negative regulation of endothelial cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.


interchromatin granule

description: A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs).


pancreatic juice secretion

description: The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.


amino-acid betaine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid.


name: peroxisome proliferator activated receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a ligand binding to an intracellular peroxisome proliferator activated receptor (alpha, beta or gamma) of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


host cell

description: A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.


adaptation of signaling pathway

description: The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.


protoporphyrinogen IX metabolic process

description: The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation.


Dysphoria

description: A state of feeling very unhappy, uneasy, or dissatisfied.


name: negative regulation of fibroblast apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.


protein localization to chromatin

description: Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.


regulation of melanosome transport

description: Any process that modulates the frequency, rate or extent of melanosome transport.


nephrogenic mesenchyme morphogenesis

description: The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron.


name: rRNA (uridine) methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine.


name: regulation of peptidyl-lysine acetylation

description: Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation.


integrin alphav-beta3 complex

description: An integrin complex that comprises one alphav subunit and one beta3 subunit.


name: regulation of steroid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.


name: positive regulation of melanocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.


striated muscle atrophy

description: A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.


macrophage chemotaxis

description: The movement of a macrophage in response to an external stimulus.


Growth delay

description: A deficiency or slowing down of growth pre- and postnatally.


name: oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin.


Rectal abscess

description: A collection of pus in the area of the rectum.


glycine N-acyltransferase activity

description: Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.


dephospho-CoA kinase activity

description: Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+.


name: positive regulation of cardiac muscle tissue growth

description: Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth.


cellular response to ATP

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.


name: negative regulation of calcium ion transmembrane transport

description: Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport.


name: secondary active sulfate transmembrane transporter activity

description: Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.


name: positive regulation of miRNA transcription

description: Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription.


establishment of lymphocyte polarity

description: The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.


podocyte cell migration

description: The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.


endothelial cell activation

description: The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


cellular response to interleukin-2

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus.


name: regulation of maintenance of mitotic sister chromatid cohesion, telomeric

description: Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric.


Wound dehiscence

description: Splitting of the sutured margins of a surgical wound. Risk factors include diabetes mellitus, obesity, and advanced age.


name: negative regulation of protein localization to cell periphery

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery.


name: establishment of epithelial cell apical/basal polarity

description: The specification and formation of the apicobasal polarity of an epithelial cell.


name: negative regulation of macrophage chemotaxis

description: Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


prostanoid metabolic process

description: The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure.


name: growth hormone-releasing hormone receptor activity

description: Combining with growth hormone-releasing hormone to initiate a change in cell activity.


structural constituent of nuclear pore

description: The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.


copper chaperone activity

description: Directly binding to and delivering copper ions to a target protein.


name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

description: A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.


protein localization to endosome

description: A process in which a protein is transported to, or maintained in, a location within an endosome.


name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP.


name: meiotic chromosome movement towards spindle pole

description: The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis.


name: negative regulation of integrin-mediated signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway.


actin filament bundle assembly

description: The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.


name: positive regulation of glycolytic process

description: Any process that activates or increases the frequency, rate or extent of glycolysis.


hyperphosphatemia

description: Abnormally high level of phosphate in the blood.


network-forming collagen trimer

description: A collagen trimer that forms networks.


MutSbeta complex

description: A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.


name: negative regulation of striated muscle contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.


phospholipase A2 activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.


activation of protein kinase A activity

description: Any process that initiates the activity of the inactive enzyme protein kinase A.


transcription factor TFTC complex

description: A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.


thyrotoxicosis

description: A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.


name: purine deoxyribonucleotide metabolic process

description: The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


regulation of cGMP-mediated signaling

description: Any process that modulates the rate, frequency or extent of cGMP-mediated signaling.


intestinal cholesterol absorption

description: Uptake of cholesterol into the blood by absorption from the small intestine.


bundle of His development

description: The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.


Abnormal urinary odor

description: A deviation from the normal odor of the urine.


name: cellular response to jasmonic acid stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.


neuropilin binding

description: Binding to a member of the neuropilin family.


spliceosomal tri-snRNP complex assembly

description: The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.


membrane biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.


AIP1-IRE1 complex

description: A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).


Traumatic hemorrhage

description: Vascular rupture, and the resulting loss of blood, due to physical injury.


response to interleukin-4

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.


thrombospondin receptor activity

description: Combining with thrombospondin and transmitting the signal to initiate a change in cell activity.


adenylyltransferase activity

description: Catalysis of the transfer of an adenylyl group to an acceptor.


name: regulation of pancreatic juice secretion

description: Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


G protein-coupled ATP receptor activity

description: Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


blackwater fever

description: A complication of malaria resulting from hemolysis.


name: radial glia guided migration of Purkinje cell

description: The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.


name: regulation of hormone biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.


name: negative regulation of natural killer cell chemotaxis

description: Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis.


name: negative regulation of mast cell activation involved in immune response

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response.


name: branching involved in prostate gland morphogenesis

description: The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.


name: negative regulation of cell adhesion mediated by integrin

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin.


3-hydroxyacyl-CoA dehydratase activity

description: Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O.


acetylcholine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.


regulation of ovulation

description: Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.


name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

description: Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.


response to linoleic acid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.


PeBoW complex

description: A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.


Intestinal bleeding

description: Bleeding from the intestines.


name: cerebellar Purkinje cell differentiation

description: The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.


type 2 immune response

description: An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.


homocysteine metabolic process

description: The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.


name: phosphatidylinositol monophosphate phosphatase activity

description: Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate.


name: negative regulation of lamellipodium organization

description: Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization.


name: establishment of mitotic spindle localization

description: The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.


hyperinsulinism

description: Abnormally high levels of insulin in the blood.


collagen receptor activity

description: Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


nuclear receptor coactivator activity

description: A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.


thioproperazine

A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10.


fourth ventricle

description: Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures.


name: dinucleotide insertion or deletion binding

description: Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion.


polyp of colon

description: A polyp that involves the colon.


Dsl1/NZR complex

description: A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p.


name: regulation of antigen processing and presentation

description: Any process that modulates the frequency, rate, or extent of antigen processing and presentation.


nephrogenic systemic fibrosis

description: Nephrogenic systemic fibrosis (NSF) is a rare systemic fibrosing condition observed in renally impaired patients and characterized by a hardening and thickening of the skin with fibrotic plaques or papules, pruritus, joint pain and stiffness, muscle weakness, limitation of range of motion, and yellowed eyes. It is generally associated with administration of gadolinium-based magnetic resonance imaging contrast agents (GBCA) in patients with kidney disease.


name: inward rectifier potassium channel complex

description: A protein complex which is capable of inward rectifier potassium channel activity.


name: positive regulation of dermatome development

description: Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.


regulation of miRNA transcription

description: Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription.


microtubule plus-end

description: The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.


Obsessive thoughts

description: A series of thoughts that are difficult to suppress and may be a consequence or cause of anxiety.


name: negative regulation of alpha-beta T cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+.


ligase regulator activity

description: Binds to and modulates the activity of a ligase.


name: phosphotransferase activity, nitrogenous group as acceptor

description: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor).


radiation pneumonitis

description: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.


name: transforming growth factor beta receptor activity

description: Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.


cytoplasmic dynein complex

description: Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.


cupric reductase activity

description: Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.


nucleotide transmembrane transport

description: The directed movement of nucleotide across a membrane.


name: positive regulation of miRNA-mediated gene silencing

description: A process that activates or increases the frequency, rate or extent of gene silencing by a microRNA (miRNA).


Metastatic liver carcinoma

description: A carcinoma that arises from the liver and has spread to another anatomic site.


name: proteasome regulatory particle, lid subcomplex

description: The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.


name: inositol bisphosphate phosphatase activity

description: Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate.


kidney vasculature morphogenesis

description: The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form.


response to forskolin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.


name: primary cutaneous T-cell non-Hodgkin lymphoma

description: A T-cell non-Hodgkin lymphoma arising from the skin. Representative examples include mycosis fungoides and primary cutaneous anaplastic large cell lymphoma.


renal water transport

description: The directed movement of water (H2O) by the renal system.


guanylate cyclase activity

description: Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.


biotin carboxylase activity

description: Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.


name: kainate selective glutamate receptor activity

description: An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist.


name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.


cellular response to misfolded protein

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.


name: somatotropin secreting cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.


DNA topological change

description: The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.


cAMP-dependent protein kinase complex

description: An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.


pro-T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.


cis-trans isomerase activity

description: Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers.


name: regulation of acyl-CoA biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.


name: guanosine-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines).


name: mature B cell differentiation involved in immune response

description: The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.


purine ribonucleoside catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.


name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.


T-helper 1 type immune response

description: An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.


natriuretic peptide receptor activity

description: Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.


Hypotonic uterine inertia

description: Greater than 20 hours of labor in nulliparous women and greater than 14 hours in parous women.


mitochondrial transcription

description: The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.


vagus nerve development

description: The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.


lipoma

description: A benign, usually painless, well-circumscribed lipomatous tumor composed of adipose tissue.


name: G protein-coupled pyrimidinergic nucleotide receptor activity

description: Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


name: cellular response to gonadotropin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.


growth involved in heart morphogenesis

description: Developmental growth that contributes to the shaping of the heart.


fasciitis

description: Inflammation process in fascia.


brachial artery

description: The brachial artery is the major blood vessel of the (upper) arm. It is the continuation of the axillary artery beyond the lower margin of teres major muscle. It continues down the ventral surface of the arm until it reaches the cubital fossa at the elbow. It then divides into the radial and ulnar arteries which run down the forearm. In some individuals, the bifurcation occurs much earlier and the ulnar and radial arteries extend through the upper arm. The pulse of the brachial artery is palpable on the anterior aspect of the elbow, medial to the tendon of the biceps, and, with the use of a stethoscope and sphygmomanometer (blood pressure cuff) often used to measure the blood pressure. The brachial artery is closely related to the median nerve; in proximal regions, the median nerve is immediately lateral to the brachial artery. Distally, the median nerve crosses the medial side of the brachial artery and lies anterior to the elbow joint. [WP,unvetted].


mesenchymal cell proliferation

description: The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.


cortisol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


learning disability

description: A group of disorders that affect a person's ability to learn or process specific types of information which is in contrast to his/her apparent level of intellect.


name: acetylcholine receptor regulator activity

description: Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.


ganglion mother cell fate determination

description: The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.


CCR4-NOT core complex

description: The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.


phosphate ion binding

description: Binding to a phosphate ion.


dGDP metabolic process

description: The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate).


response to muscle inactivity

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus.


quinone binding

description: Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.


glial cell proliferation

description: The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.


L-valine transaminase activity

description: Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.


retinal vascular disorder

description: Retinal damage resulting from diminished blood flow/oxygenation due to abnormalities of the retinal vessels. Causes include hypertension, diabetes, thrombosis, embolism, and hemorrhage.


rDNA binding

description: Binding to a DNA sequence encoding a ribosomal RNA.


IMP metabolic process

description: The chemical reactions and pathways involving IMP, inosine monophosphate.


eritrityl tetranitrate

Erythritol in which each of the hydroxy groups has been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to nitroglycerin. It is usually used diluted with lactose or other suitable inert excipients, in order to minimise the risk of explosion; undiluted erythrityl tetranitrate can be exploded by percussion or excessive heat.


corneal edema

description: Hazy, swollen cornea.


description: An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.


dUDP metabolic process

description: The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate.


zymogen granule membrane

description: The lipid bilayer surrounding a zymogen granule.


name: positive regulation of intracellular estrogen receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


DNA strand exchange activity

description: Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.


name: positive regulation of glucose mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway.


name: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

description: Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c.


name: positive regulation of protein depolymerization

description: Any process that activates or increases the frequency, rate or extent of protein depolymerization.


anchoring collagen complex

description: Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures.


Menometrorrhagia

description: Prolonged/excessive menses and bleeding at irregular intervals.


thymine metabolic process

description: The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.


telomeric DNA binding

description: Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.


neuron projection extension

description: Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


Generalized lymphadenopathy

description: A generalized form of lymphadenopathy.


centromeric DNA binding

description: Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis.


name: regulation of serine-type endopeptidase activity

description: Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity.


pulmonary venoocclusive disease

description: A disorder characterized by pulmonary venous constriction or occlusion, resulting in pulmonary hypertension.


response to stilbenoid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.


polycystin complex

description: A stable heterodimeric complex composed of polycystin-1 and polycystin-2.


peptidyl-aspartic acid hydroxylation

description: The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.


alpha2-adrenergic receptor activity

description: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.


lateral ventricle development

description: The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.


oligopeptide binding

description: Binding to an oligopeptide.


name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline

description: The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase.


name: negative regulation of chemokine (C-X-C motif) ligand 2 production

description: Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production.


cortical microtubule organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.


name: THO complex part of transcription export complex

description: The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.


name: positive regulation of vascular endothelial growth factor production

description: Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.


name: trimming of terminal mannose on B branch

description: The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.


sweet taste receptor complex

description: A protein complex which is capable of sweet taste receptor activity.


name: negative regulation of DNA-templated transcription initiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation.


Mucosal ulcer

description: A circumscribed loss of integrity of the mucous membrane.


cryptogenic organizing pneumonia

description: Cryptogenic organizing pneumonia (COP) is a form of idiopathic interstitial pneumonia characterized pathologically by organizing pneumonia (OP) that presents with non-specific flu-like symptoms, as well as cough and dyspnea and where no etiological agent is found.


synaptic vesicle lumen acidification

description: The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.


protein oxidation

description: The modification of a protein amino acid by oxidation.


Skin Burning Sensation

description: A sensation of dermal stinging or heat, not necessarily accompanied by redness or physical signs of skin irritation.


regulation of feeding behavior

description: Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.


response to glycoprotein

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.


name: positive regulation of skeletal muscle tissue growth

description: Any process that activates, maintains or increases the rate of skeletal muscle growth.


Leukoencephalopathy

description: This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells.


tooth mineralization

description: The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum.


name: hangover (any Alcohol or Other Drugs substance)


formation of radial glial scaffolds

description: The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells.


strongyloidiasis

description: An infection that is caused by nematodes of the genus Strongyloides, most commonly Strongyloides stercoralis, which is a soil-transmitted helminth, and which is characterized by a variety of gastrointestinal, dermatologic, and, occasionally, pulmonary manifestations. The worm's autoinfective life cycle can lead to hyper-infection and life-threatening dissemination in immunocompromised hosts decades after initial infection.


name: positive regulation of ryanodine-sensitive calcium-release channel activity

description: Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


ulnar nerve

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A nerve which runs near the ulna bone.


name: negative regulation of B cell mediated immunity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.


Negativism

category: biolink:Behavior biolink:OntologyClass biolink:ActivityAndBehavior biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


trimethobenzamide

The amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans.


storage vacuole

description: A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.


response to vitamin A

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.


name: neuron projection extension involved in neuron projection guidance

description: Any neuron projection extension that is involved in neuron projection guidance.


name: formation of cytoplasmic translation initiation complex

description: Joining of the large ribosomal subunit with the translation preinitiation complex, with release of IF2/eIF2 and IF3/eIF3 or IF5B/eIF5B. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.


name: negative regulation of Rac protein signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.


patched binding

description: Binding to a patched (ptc) protein, a receptor for hedgehog proteins.


name: cellular response to prostaglandin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus.


Irregular Pulse

description: Not rhythmic pulse irregular in beat or accent.


name: positive regulation of epithelial cell proliferation involved in lung morphogenesis

description: Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.


name: positive regulation of cell adhesion molecule production

description: Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.


aminophenazone

A  pyrazolone  that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.


hypertensive nephropathy

description: Kidney damage that results from chronically elevated blood pressure; complications include glomerular damage resulting in proteinuria and hematuria.


N-acetyllactosamine synthase activity

description: Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.


ribosome binding

description: Binding to a ribosome.


chemosensory behavior

description: Behavior that is dependent upon the sensation of chemicals.


name: positive regulation of protein homooligomerization

description: Any process that activates or increases the frequency, rate or extent of protein homooligomerization.


peliosis hepatis

description: A vascular disease of the liver characterized by the occurrence of multiple blood-filled cysts or cavities. The cysts are lined with endothelial cells; the cavities lined with hepatic parenchymal cells (hepatocytes). Peliosis hepatis has been associated with use of anabolic steroids (anabolic agents) and certain drugs.


name: positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity

description: Any process that activates or increases the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity.


protein-arginine deiminase activity

description: Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent.


name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

description: Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.


type I pneumocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.


rolitetracycline

A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.


endocardial cushion morphogenesis

description: The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


photoreceptor cell maintenance

description: Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.


name: large conductance calcium-activated potassium channel activity

description: Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


name: negative regulation of dopamine receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


eye pigment biosynthetic process

description: The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.


rib

description: An intersegmental rod-shaped bone that forms in the peritoneal membrane and attach to the vertebral parapophyses.


flupentixol

A flupenthixol in which the double bond adopts a cis-configuration.


Bloody Discharge

description: The leaking of serosanguinous fluids from an orifice or wound.


name: germ-line stem cell population maintenance

description: Any process by which an organism or tissue maintains a population of germ-line stem cells.


myocardial rupture

description: Disease-related laceration or tearing of tissues of the heart, including the free-wall MYOCARDIUM; HEART SEPTUM; PAPILLARY MUSCLES; CHORDAE TENDINEAE; and any of the HEART VALVES. Pathological rupture usually results from myocardial infarction (HEART RUPTURE, POST-INFARCTION).


name: calcium-induced calcium release activity

description: Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration.


Monoplegia

description: Paralysis that affects one limb.


name: establishment of planar polarity involved in neural tube closure

description: Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


Leg Ulcer

description: A circumscribed, inflammatory, and often suppurating lesion that causes necrosis of tissue on the skin of the limb comprising the hip, thigh, leg and foot.


regulation of mitotic recombination

description: Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.


epidermal lamellar body

description: A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.


name: gamma-aminobutyric acid transmembrane transporter activity

description: Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA).


cerebrospinal fluid secretion

description: The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces.


formate metabolic process

description: The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.


name: positive regulation of Rho protein signal transduction

description: Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.


response to herbicide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.


glycogenin glucosyltransferase activity

description: Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin.


sternum

description: A midventral endochondral skeletal element which represents the origin site of the pectoral muscles[PHENOSCAPE:ad].


name: adenylate cyclase-inhibiting opioid receptor signaling pathway

description: An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process.


name: negative regulation of dopaminergic neuron differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation.


name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

description: Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.


neurofilament bundle assembly

description: The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules.


Loss of voice

description: A term referring to the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).


name: positive regulation of somatostatin secretion

description: Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


name: dopamine neurotransmitter receptor activity

description: Combining with the neurotransmitter dopamine to initiate a change in cell activity.


CXCR3 chemokine receptor binding

description: Binding to a CXCR3 chemokine receptor.


name: positive regulation of alkaline phosphatase activity

description: Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.


Eyelid retraction

description: With the eyes in primary position, the sclera is visible above the superior corneal limbus.


methotrexate binding

description: Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.


name: baroreceptor response to decreased systemic arterial blood pressure

description: The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels.


THO complex

description: The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.


corpus luteum

description: A transient endocrine gland that develops from the postovulatory or atretic follicles and secretes progesterone; it is thought to be related to egg retention[PMID].


flagellated sperm motility

description: The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.


adenosine-phosphate deaminase activity

description: Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP.


ichthyosis

description: Disorders of cornification that are characterized by visible scaling and/or hyperkeratosis of most or all of the skin. Inherited ichthyoses, defined as the generalized form of Mendelian disorders of cornification, affect most or all of the skin. This etiologically and phenotypically heterogenous group of conditions is caused by mutations in various different genes important for keratinocyte differentiation and epidermal barrier function. Acquired forms of ichthyosis can be observed with certain autoimmune, inflammatory, metabolic, endocrine, or infectious diseases or with malignancies.


name: thyroid-stimulating hormone-secreting cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin.


T-wave inversion

description: An inversion of the T-wave (which is normally positive).


name: ciliary neurotrophic factor receptor binding

description: Binding to a ciliary neurotrophic factor receptor.


dimethylallyltranstransferase activity

description: Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.


name: double-stranded RNA-specific ribonuclease activity

description: Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules.


Lower gastrointestinal hemorrhage

description: Bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).


polyprenol metabolic process

description: The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.


name: negative regulation of cytoplasmic pattern recognition receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway.


name: negative regulation of skeletal muscle tissue development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.


regulation of NK T cell proliferation

description: Any process that modulates the frequency, rate or extent of natural killer T cell proliferation.


ATP-dependent protein binding

description: Binding to a protein or protein complex using energy from ATP hydrolysis.


glycerol channel activity

description: Enables the energy-independent facilitated diffusion of glycerol through a transmembrane aqueous pore or channel.


optic chiasma

description: A decussation of the diencephalon where the fibers of the optic nerve cross.


PAN complex

description: A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.


name: positive regulation of trophoblast cell migration

description: Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.


name: negative regulation of photoreceptor cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.


salicylamide

The simplest member of the class of salicylamides derived from salicylic acid.


name: positive regulation of fibroblast apoptotic process

description: Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.


histone locus body

description: A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.


prostate glandular acinus development

description: The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland.


name: positive regulation of miRNA metabolic process

description: Any process that activates or increases the frequency, rate or extent of miRNA metabolic process.


L-ascorbic acid

The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.


name: negative regulation of biomineral tissue development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.


post-embryonic animal morphogenesis

description: The process, occurring after animal embryonic development, by which anatomical structures are generated and organized.


name: nuclear polyadenylation-dependent mRNA catabolic process

description: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA.


name: nonribosomal peptide biosynthetic process

description: The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.


X chromosome

description: The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.


cloacal exstrophy

description: A major birth defect representing the severe end of the spectrum of the exstrophy-epispadias complex (EEC) characterized by omphalocele, exstrophy, imperforate anus and spinal defects (also referred to as the OEIS complex), often associated with other malformations.


equilibrioception

description: The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.


RNA polymerase III complex

description: RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.


inositol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.


name: regulation of ketone biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells.


dTTP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.


name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan

description: The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring.


DNA double-strand break processing

description: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.


Muscle hemorrhage

description: Bleeding occuring within a muscle


BLOC-2 complex binding

description: Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.


reticular formation

description: A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ).


middle ear morphogenesis

description: The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).


fat-soluble vitamin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.


name: minor groove of adenine-thymine-rich DNA binding

description: Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins.


endothelial cell apoptotic process

description: Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.


cyclase activator activity

description: Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction.


sweet syndrome

description: Sweet's syndrome (the eponym for acute febrile neutrophilic dermatosis) is characterized by a constellation of clinical symptoms, physical features, and pathologic findings which include fever, neutrophilia, tender erythematous skin lesions (papules, nodules, and plaques), and a diffuse infiltrate consisting predominantly of mature neutrophils that are typically located in the upper dermis.


vitamin transmembrane transport

description: The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


Acute sinusitis

description: An acute form of sinusitis.


diphosphotransferase activity

description: Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor).


paranodal junction assembly

description: Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.


JUN kinase binding

description: Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.


primary lysosome

description: A lysosome before it has fused with a vesicle or vacuole.


adenyl deoxyribonucleotide binding

description: Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


description: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+.


name: regulation of phospholipid catabolic process

description: Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.


bone tissue

description: Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.


response to corticosterone

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.


immunoglobulin complex

description: A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.


name: inositol trisphosphate phosphatase activity

description: Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate.


Hypergastrinemia

description: An elevated amount of gastrin in the blood.


name: atrial cardiac muscle cell to AV node cell signaling

description: Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell.


dysthymic disorder

description: A chronic mood disorder in which the symptoms are similar to, though milder than, those diagnosed in depression.


Male sexual dysfunction

description: A problem occurring during any phase of the male sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity


name: respiratory syncytial virus infectious disease

description: Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children.


Golgi ribbon formation

description: The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae.


tubulin deacetylase activity

description: Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate.


name: negative regulation of antigen receptor-mediated signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.


hindgut development

description: The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.


name: L-glutamine transmembrane transporter activity

description: Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid.


name: regulation of branching involved in prostate gland morphogenesis

description: Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.


cellular response to leucine starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine.


B cell chemotaxis

description: The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


ophthalmic herpes zoster

description: Virus infection of the Gasserian ganglion and its nerve branches characterized by pain and vesicular eruptions with much swelling. Ocular involvement is usually heralded by a vesicle on the tip of the nose. This area is innervated by the nasociliary nerve.


name: plus-end-directed microtubule motor activity

description: A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.


Injection site thrombophlebitis

description: Thrombophlebitis in the veins surrounding an injection site.


name: regulation of cargo loading into COPII-coated vesicle

description: Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle.


name: protein transport from ciliary membrane to plasma membrane

description: The directed movement of protein from ciliary membrane to plasma membrane.


N-acetylneuraminate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.


macropinosome

description: A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.


name: modulation by host of symbiont transcription

description: Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription.


membrane lipid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane.


name: positive regulation of renal sodium excretion

description: Any process that increases the amount of sodium excreted in urine over a unit of time.


protein transport within lipid bilayer

description: The directed movement of a protein from one location to another within a lipid bilayer.


testicular disorder

description: A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.


morphogenesis of a polarized epithelium

description: The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.


TRAF2-GSTP1 complex

description: A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.


name: positive regulation of cortisol secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell.


name: TIM23 mitochondrial import inner membrane translocase complex

description: The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.


description: Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.


immunological synapse

description: An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.


lipid phosphorylation

description: The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.


hyperosmotic response

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.


name: L-ornithine transmembrane transporter activity

description: Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.


name: mitochondrial outer membrane translocase complex

description: A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments.


palmitoyl-(protein) hydrolase activity

description: Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.


name: regulation of glucocorticoid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.