vestibular ligament

description: The vestibular fold is a fibroelastic band which passes from the ventral margin of the cuneiform cartilage to the cranial dorsal surface of the thyroid cartilage. It forms the support for the free edge of the vestibular fold.


lieno-renal ligament

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Peritoneum that attaches the spleen to the posterior abdominal wall over the left kidney. develops from the dorsal mesogastrium of the embryo[umich].


suspensory ligament of ovary

description: A fold of peritoneum that extends out from the ovary to the wall of the pelvis.


round ligament of uterus

description: The round ligament of the uterus originates at the uterine horns, in the parametrium. It leaves the pelvis via the deep inguinal ring, passes through the inguinal canal and continues on to the labia majora where its fibers spread and mix with the tissue of the mons pubis[WP]. A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus[MESH].


cricothyroid ligament

description: This attaches the caudal border of the thyroid cartilage to the ventral arch of the cricoid cartilage. Its sheetlike ventral portion is sometimes referred to as the cricothyroid membrane. Being elastic, it 'balances' movement at the hinge-like cricothyroid joint and determines the resting position of the larynx when the muscles are relaxed[MURDOCH]. The cricothyroid ligament is the larger part of the laryngeal membrane, continuing inferiorly as a median or anterior part and twin lateral ligaments. The median cricothyroid ligament is a flat band of white tissue joining the cricoid and thyroid cartilages, while the lateral cricothyroid ligament is also known as the cricothyroid membrane (also called conus elasticus).


crico-esophageal tendon

description: Longitudinal fibers of the esophagus that attaches to the posterior aspect of the cricoid cartilage of the larynx.


cranial suspensory ligament

description: Connects the cranial tip of the future gonad to the dorsocranial abdominal cavity.


posterior incudal ligament

description: A fold of mucous membrane that runs from the fossa incudus to the incus.


falciform ligament

description: A ligament that attaches the liver to the anterior body wall. It is a broad and thin antero-posterior peritoneal fold, falciform in shape, its base being directed downward and backward and its apex upward and backward. It is a remnant of the ventral mesentery of the fetus. It is situated in an antero-posterior plane but lies obliquely, so that one surface faces forward and is in contact with the peritoneum behind the right rectus and the diaphragm, while the other is directed backward and is in contact with the left lobe of the liver. It is attached by its left margin to the under surface of the diaphragm and the posterior surface of the sheath of the right Rectus as low down as the umbilicus; by its right margin it extends from the notch on the anterior margin of the liver, as far back as the posterior surface. It is composed of two layers of peritoneum closely united together. Its base or free edge contains between its layers the round ligament and the paraumbilical veins[WP].


hepatogastric ligament

description: Ligament extending between the liver and stomach.


annular ligament of stapes

description: A ring of fibrous tissue that connects the base of the stapes to the oval window of the inner ear.


thyroepiglottic ligament

description: Laryngeal ligament that connects the epiglottis to the thyroid cartilage[WP,modified].


suspensory ligament

description: A ligament that supports a body part, especially an organ.


gubernaculum (female)

description: A gubernaculum that is part of a female reproductive system.


lateral thyrohyoid ligament

description: The lateral thyrohyoid ligament (lateral hyothyroid ligament) is a round elastic cord, which forms the posterior border of the hyothyroid membrane and passes between the tip of the superior cornu of the thyroid cartilage and the extremity of the greater cornu of the hyoid bone. The recurrent laryngeal nerve typical lies lateral to this ligament.


indole phytoalexin catabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response.


melatonin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine).


name: melibiose transmembrane transporter activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants.


name: melibiose:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in).


name: melibiose:monoatomic cation symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in).


cellular response to neutral pH

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


Recurrent Acute Monocytic Leukemia

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: The reemergence of acute monocytic leukemia after a period of remission.


Acute monocytic/monoblastic leukemia

description: Acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage, including monoblasts, promonocytes, and monocytes. Bleeding disorders are common presenting features.


Childhood Acute Monoblastic Leukemia

description: An acute monoblastic leukemia occurring in children.


name: acute monoblastic/monocytic leukemia in relapse

description: The reemergence of acute monoblastic and monocytic leukemia after a period of remission.


Adult Acute Monoblastic Leukemia

description: An acute monoblastic leukemia occurring in adults.


name: Refractory Acute Monoblastic and Monocytic Leukemia

description: Acute monoblastic and monocytic leukemia that does not respond to treatment.


name: Adult Acute Monoblastic and Monocytic Leukemia

description: An acute monoblastic and monocytic leukemia occurring in adults.


adult acute monocytic leukemia

description: A acute monocytic leukemia that occurs in an adult.


aleukemic monocytic leukemia cutis

description: Aleukemic leukemia cutis where the skin in infiltrated by neoplastic monocytes.


Childhood Acute Monocytic Leukemia

description: An acute monocytic leukemia occurring in children.


name: Childhood Acute Monoblastic and Monocytic Leukemia

description: An acute monoblastic and monocytic leukemia occurring in children.


Tonic Neck Reflex

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: An involuntary, primal response in the neonate in which the arm extends to follow the infant's gaze, while the opposing arm and leg flex inward.


Developmental Finding

description: Symptoms, physical examination results, and/or laboratory test results related to physical, emotional, behavioral, or social development.


Iatrogenic Growth Failure

description: Growth failure due to medical intervention.


name: Periventricular Hemorrhage of the Newborn

description: Bleeding into the brain tissue adjacent to the lateral cerebral ventricles of newborn infant.


name: Small for Gestational Age for Weight and Length

description: Birth weight and length greater than two standard deviations below the mean for the reference population of the same sex and gestational age.


Sucking Reflex

description: An involuntary, primal response in the neonate when a nipple is placed on an infant's lips.


Step Reflex

description: An involuntary, primal response in the neonate to take brisk steps when the feet are placed on a surface whilst in a supported standing position.


Small for Gestational Age for Weight

description: Birth weight greater than two standard deviations below the mean for the reference population of the same sex and gestational age.


Rooting Reflex

description: An involuntary, primal response in the neonate to search for the nipple when the cheek is touched.


Infantile Colic

description: Paroxysms of irritability, fussing or crying that starts and stops without obvious cause in an infant up to four months of age without failure to thrive. Episodes last three or more hours per day for at least three days per week for at least on week.


name: Small for Gestational Age with Failure of Catch-Up Growth

description: A condition in which a child who was born small for gestational age, fails to achieve a linear growth rate sufficient to restore height to within the normal range for the reference population.


name: Transient Leukemoid Reaction of the Newborn

description: Increased white blood cell count and increased neutrophil precursors resembling leukemia in a neonate or fetus. Often, this is a response to medications received, infection or Down syndrome.


Newborn or Infant Finding

description: Clinical, laboratory or molecular evidence, or absence of evidence of disease in a neonate or infant.


Failure to thrive in infant

description: A clinical finding indicating less than normal growth in infancy.


Growth Failure of Unknown Etiology

description: Subnormal linear growth rate in an infant, child or adolescent based on the normative values for the age and sex of the reference population; the cause of the growth failure is unknown.


name: Intraventricular (nontraumatic) hemorrhage, grade 1, of fetus and newborn

description: Bleeding into the thick layer of immature cells under the ependymal lining at the ventrolateral aspect of the lateral cerebral ventricles of a newborn.


Failure of Catch-Up Growth

description: Failure to achieve a linear growth rate sufficient to restore height to within the normative range for the reference population.


Small for Gestational Age for Length

description: Birth length greater than two standard deviations below the mean for the reference population of the same sex and gestational age.


Infant Reflex

description: Primitive reflex actions that newborns display in response to specific stimuli. These reflexes are involuntary and most disappear as the infant matures.


Galant Reflex

description: An involuntary, primal response in the neonate in which a finger is run down one side of the spine and the neonate laterally flexes toward that side.


Grasp Reflex

description: An involuntary, primal response in the neonate to grasp the fingers when their palm is touched. This reflex is present until six months of age.


name: Intraparenchymal Hemorrhage of the Newborn

description: Bleeding into the brain tissue of a newborn infant.


Moro Reflex

description: An involuntary, primal response in the neonate to loud noise or the feeling of falling. The response is characterized by the infant's arms symmetrically spreading out to the side and then back to the midline, and involuntarily flexing the fingers and toes.


Plantar Grasp Reflex

description: A newborn reflex that is characterized by flexion of the toes when the sole of the foot is stroked.


name: negative regulation of stomach neuroendocrine cell differentiation

description: Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.


name: regulation of stomach neuroendocrine cell differentiation

description: Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.


RD3-related retinopathy

description: Any retinopathy caused by variants in the RD3 gene.


Leber congenital amaurosis 12

description: Any Leber congenital amaurosis in which the cause of the disease is a mutation in the RD3 gene.


name: mitochondrial complex 1 deficiency, nuclear type 14


3,4-dihydrocoumarin hydrolase activity

description: Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate.


name: negative regulation of angiotensin-activated signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway.


dense regular connective tissue

description: Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).


dense connective tissue

description: Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.


dense irregular connective tissue

description: Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.


name: RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-threonine (consensus YSPTSPS)(position 4) + H2O = RNA polymerase II large subunit + phosphate.


glycerol-3-phosphatase activity

description: Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.


name: protein tyrosine phosphatase activity, metal-dependent

description: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions.


description: Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate.


description: Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate.


thymidylate 5'-phosphatase activity

description: Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate.


3-phosphoglycerate phosphatase activity

description: Catalysis of the reaction: 3-phospho-D-glycerate + H2O = D-glycerate + phosphate.


name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity

description: Catalysis of the reaction: H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.


description: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.


description: Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate.


name: calcium-dependent phospholipase C activity

description: Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+.


ecdysone-phosphate phosphatase activity

description: Catalysis of the reaction: ecdysone 22-phosphate + H2O = ecdysone + hydrogenphosphate.


description: Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate.


name: calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

description: Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.


description: Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate.


description: Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate.


description: Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate.


name: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands

description: Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand.


name: sphingomyelin phosphodiesterase D activity

description: Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+.


description: Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate.


description: Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate.


trehalose-phosphatase activity

description: Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate.


description: Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate.


pseudouridine 5'-phosphatase activity

description: Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.


description: Catalysis of the reaction: 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate.


name: acid sphingomyelin phosphodiesterase activity

description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment.


streptomycin-6-phosphatase activity

description: Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin.


description: Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate.


protein histidine phosphatase activity

description: Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate.


glucosylglycerol 3-phosphatase activity

description: Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate.


name: RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate.


IMP 5'-nucleotidase activity

description: Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate.


name: D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase activity

description: Catalysis of the reaction: D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate.


description: Catalysis of the reaction: H2O + phosphoenolpyruvate = phosphate + pyruvate.


[phosphorylase] phosphatase activity

description: Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate.


description: Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate.


dGTPase activity

description: Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate.


3'-nucleotidase activity

description: Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.


description: Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.


description: Catalysis of the reaction: H2O + serine phosphoethanolamine = H+ + phosphoethanolamine + serine.


5-phytase activity

description: Catalysis of the reaction: 1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate.


glycerol-2-phosphatase activity

description: Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate.


histidinol-phosphatase activity

description: Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate.


description: Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate.


glucose-1-phosphatase activity

description: Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate.


name: RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate.


phosphocholine phosphatase activity

description: Catalysis of the reaction: choline phosphate + H2O = choline + phosphate.


sorbitol-6-phosphatase activity

description: Catalysis of the reaction: D-glucitol 6-phosphate + H2O = D-glucitol + phosphate.


description: Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.


tyrosyl-RNA phosphodiesterase activity

description: Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.


ribitol-5-phosphatase activity

description: Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate.


name: photoreceptor cyclic-nucleotide phosphodiesterase activity

description: Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide.


description: Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate.


name: RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate.


description: Catalysis of the reaction: sn-glycero-3-phosphocholine + H2O = choline phosphate + glycerol + H+.


alkylacetylglycerophosphatase activity

description: Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = 2-acetyl-1-alkyl-sn-glycerol + phosphate.


phosphoglycerate phosphatase activity

description: Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate.


description: Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+.


dolichyl-phosphatase activity

description: Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate.


description: Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate.


name: mannosyl-inositol phosphorylceramide phospholipase activity

description: Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol.


phosphatidylglycerophosphatase activity

description: Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.


name: triphosphoric monoester hydrolase activity

description: Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group.


deoxynucleotide 3'-phosphatase activity

description: Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate.


protein arginine phosphatase activity

description: Catalysis of the reaction: phospho-L-arginyl-[protein] +H2O = L-arginyl-[protein] + phosphate.


cardiolipin hydrolase activity

description: Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA).


name: deoxynucleoside triphosphate hydrolase activity

description: Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate.


acireductone synthase activity

description: Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate.


NADPH phosphatase activity

description: Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate.


name: 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity

description: Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = H+ + alpha-D-ribose 1,5-bisphosphate.


name: mannosyl-diinositol phosphorylceramide phospholipase activity

description: Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol.


sedoheptulose-bisphosphatase activity

description: Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate.


description: Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.


name: inositol pentakisphosphate phosphatase activity

description: Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate.


description: Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate.


description: Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene.


myosin-light-chain-phosphatase activity

description: Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate.


NADP phosphatase activity

description: Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate.


myosin phosphatase activity

description: Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.


5'-deoxynucleotidase activity

description: Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate.


2-deoxyglucose-6-phosphatase activity

description: Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.


description: Catalysis of the reaction: (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate.


name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate

description: The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate.


description: Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate.


description: Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.


description: Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.


description: Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate.


description: Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate.


description: Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.


description: Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.


description: Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.


description: Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate.


FMN hydrolase activity

description: Catalysis of the reaction: FMN + H2O = phosphate + riboflavin.


glycerol-1-phosphatase activity

description: Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate.


description: Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.


description: Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol.


name: [isocitrate dehydrogenase (NADP+)] phosphatase activity

description: Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate.


name: phosphatidylglycerol phospholipase C activity

description: Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate.


name: D-ribose 2,5-bisphosphate 2-phosphohydrolase activity

description: Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate = hydrogenphosphate + D-ribofuranose 5-phosphate.


4-phytase activity

description: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.


description: Catalysis of the reaction: geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate.


name: inositol phosphorylceramide phospholipase activity

description: Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol.


description: Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+.


description: Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate.


name: diphosphoric monoester hydrolase activity

description: Catalysis of the hydrolysis of a diphosphoester, releasing a diphosphate and a free hydroxyl group.


JUN kinase phosphatase activity

description: Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate.


description: Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.


name: inositol phosphosphingolipid phospholipase activity

description: Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol.


description: Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate.


name: RNA 2',3'-cyclic 3'-phosphodiesterase activity

description: Catalysis the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H+.


name: phosphatidylcholine phospholipase C activity

description: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine.


fructose-1-phosphatase activity

description: Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O = beta-D-fructofuranose + hydrogenphosphate.


sucrose-phosphate phosphatase activity

description: Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate.


name: RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity

description: Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 7) + H2O = RNA polymerase II large subunit + phosphate.


protein adenylylhydrolase activity

description: Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins.


NMN phosphatase activity

description: Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate.


phosphoric triester hydrolase activity

description: Catalysis of the hydrolysis of a phosphoric triester.


mannitol-1-phosphatase activity

description: Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate.


name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity

description: Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)].


prenyl-diphosphatase activity

description: Catalysis of the reaction: dimethylallyl diphosphate + H2O = diphosphate + prenol.


description: Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose.


[pyruvate kinase]-phosphatase activity

description: Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate.


description: Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA.


thiamine phosphate phosphatase activity

description: Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate.


description: Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate.


description: Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H+.


description: Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP.


name: neutral sphingomyelin phosphodiesterase activity

description: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment.


description: Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid.


description: Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate.


name: inositol hexakisphosphate 2-phosphatase activity

description: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate.


name: 3',5'-nucleotide bisphosphate phosphatase activity

description: Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate.


name: GPI-mannose ethanolamine phosphate phosphodiesterase activity

description: A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor.


name: 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity

description: Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = D-ribofuranose 2,5-bisphosphate + H+.


name: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity

description: Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+.


description: Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate.


L-phosphoserine phosphatase activity

description: Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid.


XMP 5'-nucleosidase activity

description: Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine.


description: Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate.


name: glycosylphosphatidylinositol phospholipase D activity

description: Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.


name: L-threonine O-3-phosphate phosphatase activity

description: Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate.


description: Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate.


description: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.


description: Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate.


alpha-ribazole phosphatase activity

description: Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.


3-phytase activity

description: Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate.


name: positive regulation of autophagic cell death

description: Any process that activates or increases the frequency, rate or extent of autophagic cell death.


iliolumbar vein

description: The iliolumbar vein is the vena comitans of the iliolumbar artery. The obturator nerve crosses superficial to it. A single vein is found more commonly than a double vein. It drains vertebral segments four and five. It is closely related to the ascending lumbar vein. [WP,unvetted].


4-nitrophenol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion.


name: Resectable Adenocarcinoma of Unknown Primary

description: An adenocarcinoma of unknown primary that is amenable to surgical resection.


Resectable Carcinoma of Unknown Primary

description: A carcinoma of unknown primary that is amenable to surgical resection.


Nipple Sensation Change or Loss

description: Excessive sensitivity or changes in sensitivity in the nipple(s).


gibberellin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.


secretory meningioma

description: A WHO grade I meningioma characterized by the presence of epithelial differentiation and numerous intracellular PAS positive bodies that are rich in glycogen.


description: Catalysis of the reaction:guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine.


Red cell adenylate kinase deficiency

description: An autosomal recessive disorder caused by mutation of the AK1 gene. It is associated with moderate to severe non-spherocytic hemolytic anemia and, in some cases, with intellectual disability and psychomotor impairment.


name: anemia due to erythrocyte enzyme disorder

description: Any form of anemia that results from the absence of, or the defective action of, any enzyme involved in erythropoiesis.


name: glycogen storage disease due to phosphoglycerate mutase deficiency

description: A rare, autosomal recessive, inherited disorder caused by mutation of the PGAM2 gene. It is characterized by non-spherocytic hemolytic anemia, exercise-induced cramping, myoglobinuria, and presence of tubular aggregates on muscle biopsy.


Deficiency of hexokinase (disorder)

description: A rare, autosomal recessive, inherited disorder caused by mutation of the HK1 gene. It is characterized by the early-onset of severe, non-spherocytic hemolytic anemia.


Glucose phosphate isomerase deficiency

description: A rare, autosomal recessive, inherited disorder caused by mutation of the GPI gene. It is characterized by chronic, non-spherocytic hemolytic anemia.


Deficiency of enolase

description: A rare, autosomal dominant, inherited disorder caused by mutation of the ENO1 gene. It is associated with spherocytic hemolytic anemia, exercise-induced myalgia and weakness.


triosephosphate isomerase deficiency

description: Triosephosphate isomerase (TPI) deficiency is a severe autosomal recessive inherited multisystem disorder of glycolytic metabolism characterized by hemolytic anemia and neurodegeneration.


name: hemolytic anemia due to diphosphoglycerate mutase deficiency

description: A rare, autosomal recessive, inherited disorder caused by mutation of the BPGM gene. It is characterized by hemolytic anemia and splenomegaly.


name: Uridine monophosphate hydrolase deficiency

description: An autosomal recessive disorder caused by mutation of the NT5C3A gene. It is the most frequent abnormality of red cell nucleotide metabolism, causing chronic, non-spherocytic hemolytic anemia. Most affected individuals have Mediterranean, Jewish, or African ancestry. Basophilic stippling and accumulation of pyrimidines within erythrocytes are hallmarks of this disorder.


name: positive regulation of mitotic nuclear envelope disassembly

description: Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly.


thiocarbamic ester

Any organonitrogen compound with formula RS-C(=X)NH2 where X = O (monothiocarbamic esters) or S (dithiocarbamic esters), or their N-substituted derivatives.


monothiocarbamic ester

A thiocarbamic ester formally derived from a monothiocarbamic acid.


4-chlorobenzaldehyde oxidase activity

description: Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-.


composite hemangioendothelioma

description: An intermediate, locally aggressive and rarely metastasizing blood vessel neoplasm. It is characterized by the presence of spindle, plump, and epithelioid endothelial cells and cellular atypia.


Intermediate Vascular Neoplasm

description: A vascular neoplasm with borderline malignant potential.


retiform hemangioendothelioma

description: An intermediate, locally aggressive and rarely metastasizing blood vessel neoplasm. It is characterized by the presence of hobnail endothelial cells and formation of arborizing vascular channels.


kaposiform hemangioendothelioma

description: Kaposiform hemangioendothelioma is a very rare, aggressive, vascular tumor manifesting in the neonatal period or in infancy as cutaneous vascular tumors to large infiltrative lesions.


name: Endovascular papillary angioendothelioma of childhood

description: A papillary intralymphatic angioendothelioma that occurs during childhood.


name: Intermediate (Locally Aggressive) Blood Vessel Neoplasm

description: A borderline blood vessel neoplasm that has locally aggressive behavior.


name: Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma

description: An intermediate, rarely metastasizing blood vessel neoplasm that more frequently affects young adult males and usually arises in the lower limbs.  In approximately half of the affected patients the tumor is painful and in two-thirds of the patients the tumor is multifocal.  Morphologically it is characterized by the presence of sheets and fascicles of spindle cells with abundant eosinophilic cytoplasm and vesicular nuclei.  Cytologic atypia is usually mild.  Approximately 60% of the patients develop local recurrences or additional tumors in the same anatomic region.


name: Intermediate (Rarely Metastasizing) Blood Vessel Neoplasm

description: A borderline blood vessel neoplasm that may metastasize on rare occasions.


Intermediate Blood Vessel Neoplasm

description: A borderline blood vessel neoplasm that can be locally aggressive, and may metastasize on rare occasions.


description: A pseudomyogenic hemangioendothelioma that occurs during childhood.


description: An intermediate, rarely metastasizing blood vessel neoplasm. It is characterized by the presence of lymphatic-like vascular channels and papillary endothelial proliferation.


description: A kaposiform hemangioendothelioma that occurs during childhood.


Polymorphus Hemangioendothelioma

description: An intermediate, rarely metastasizing blood vessel neoplasm. It is characterized by the presence of a polymorphic cellular infiltrate.


mild ichthyosis vulgaris

description: An instance of ichthyosis vulgaris in which the disease presentation is mild in severity. Heterozygote FLG mutation carriers often have mild manifestations.


Elevated Expression

description: An indication that the expression of a gene, transcript or protein is higher than a previous value or a normal range of values.


TP53 Overexpression Positive

description: An indication that overexpression of TP53 has been detected in a sample.


Melanosomal Genes Overexpression

description: An indication that overexpression of genes involved in melanosomal biogenesis or melanin biosynthesis has been detected in a sample.


TBX21 Overexpression Positive

description: An indication that overexpression of T-box 21 (TBX21) has been detected in a sample.


MiRNA 371-373 Overexpression

description: An indication that microRNAs found in the miRNA 371-373 cluster are overexpressed in a sample.


Achaete-Scute Homolog 1 Overexpression

description: An indication that overexpression of achaete-scute homolog 1 has been detected in a sample.


name: Fibroblast Growth Factor 1 Overexpression


BCL2 Overexpression Positive

description: An indication that overexpression of BCL2 has been detected in a sample.


name: Presence of ERBB2 Overexpressing Disseminated Tumor Cells

description: An indication that single tumor cells or small clusters of tumor cells that are overexpressing ERBB2 are present in a tissue sample.


Elevated ALCAM

description: A finding indicating elevated concentrations of ALCAM in a sample.


BCL6 Overexpression Positive

description: An indication that overexpression of BCL6 has been detected in a sample.


name: Interleukin-6 Greater than or Equal to 80 pg/ml

description: A finding indicating that the concentration of the interleukin-6 in a sample is greater than or equal to 80 pg/mL.


THBS1 Overexpression Positive

description: An indication that overexpression of THBS1 has been detected in a sample.


HIF1A Overexpression Positive

description: An indication that overexpression of HIF1A has been detected in a sample.


MYC Overexpression

description: An indication that overexpression of the MYC gene has been detected in a sample.


HRAS Overexpression Positive

description: An indication that overexpression of HRAS has been detected in a sample.


Elevated SLC34A2 Positive

description: A finding indicating detection of elevated expression of SLC34A2 in a sample.


name: Neurogenic Differentiation Factor 1 Overexpression

description: An indication that overexpression of neurogenic differentiation factor 1 has been detected in a sample.


FGFR1 Overexpression Positive

description: An indication that overexpression of FGFR1 has been detected in a sample.


name: Transforming Growth Factor-Beta Overexpression


Elevated CCR8 Expression

description: A finding indicating elevated levels of expression of CCR8 were detected in a sample.


NY-ESO-1 Overexpression Positive

description: An indication that overexpression of NY-ESO-1 has been detected in a sample.


Elevated MET Protein Expression

description: An indication that elevated concentrations of MET protein were found in a sample.


MET Overexpression Positive

description: An indication that overexpression of MET has been detected in a sample.


name: Elevated Inflammatory Gene Signature Expression

description: A genetic finding indicating that tumor cells express elevated levels of genes encoding proteins involved in inflammation and immunity. This signature may include elevated expression of genes involved in interferon signaling, antigen presentation, immune checkpoint regulation and/or the differentiation and activation of cytotoxic T-cells.


VEGF Overexpression Positive

description: An indication that overexpression of a member of the VEGF family has been detected in a sample.


FGFR3 Overexpression Positive

description: An indication that overexpression of FGFR3 has been detected in a sample.


AXL Overexpression Positive

description: An indication that overexpression of AXL has been detected in a sample.


POU Class 2 Homeobox 3 Overexpression

description: An indication that overexpression of POU class 2 homeobox 3 has been detected in a sample.


NTRK1 Overexpression Positive

description: An indication that overexpression of NTRK1 has been detected in a sample.


FGF23 Overexpression Positive

description: An indication that overexpression of FGF23 has been detected in a sample.


name: Fibroblast Growth Factor 2 Overexpression


EZHIP Overexpression Positive

description: An indication that overexpression of EZHIP has been detected in a sample.


Yes-Associated Protein 1 Overexpression

description: An indication that overexpression of yes-associated protein 1 has been detected in a sample.


name: Sonic Hedgehog Pathway Genes Overexpression

description: An indication that overexpression of one or more genes in the sonic hedgehog (SHH) pathway has been detected in a sample.


FGFR2 Overexpression Positive

description: An indication that overexpression of FGFR2 has been detected in a sample.


GRPR Overexpression Positive

description: An indication that overexpression of GRPR has been detected in a sample.


GATA3 Overexpression Positive

description: An indication that overexpression of GATA3 has been detected in a sample.


ERBB2 Overexpression

description: An indication that overexpression of ERBB2 has been detected in a sample.


KIT Overexpression Positive

description: An indication that overexpression of KIT has been detected in a sample.


NECTIN4 Overexpression Positive

description: An indication that overexpression of NECTIN4 has been detected in a sample.


description: Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA.


description: Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA.


description: Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA.


description: Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA.


glycine C-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA.


formate C-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.


Hemolymphangioma

description: A hemorrhagic lymphatic lesion characterized by the presence of dilated lymphatic spaces, extravasation of red blood cells, hemosiderin deposition, and fibrosis.


name: Stage IIIA Childhood Testicular Germ Cell Tumor by Toronto Guidelines v2

description: Any pT, Any N, M1, S0, S1. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


chilblain lupus 1

description: Any chilblain lupus in which the cause of the disease is a mutation in the TREX1 gene.


chronic cutaneous lupus erythematosus

description: Chronic cutaneous lupus erythematosus (CCLE) is a form of cutaneous lupus erythematosus (CLE) that includes five different forms: discoid lupus erythematosus (DLE), chilblain lupus, hypertrophic or verrucous lupus erythematosus, lupus erythematosus tumidus, and lupus erythematosus panniculitis.


name: hypertrophic or verrucous lupus erythematosus


familial chilblain lupus

description: An instance of Chilblain lupus that is caused by an inherited modification of the individual's genome.


lupus erythematosus panniculitis

description: A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.


chilblain lupus 2

description: Any chilblain lupus in which the cause of the disease is a mutation in the SAMHD1 gene.


chilblain lupus

description: A rare, chronic cutaneous lupus erythematosus disease characterized by red or violaceous, initially pruritic (evolving to painful) papules and plaques located on acral areas (especially dorsal aspects of fingers and toes, while the nose and ear involvement is uncommon), exacerbated by cold and damp conditions, with fissuring and ulceration occasionally observed. Coexistence of discoid lupus erythematosus lesions elsewhere on the body and occasional progression to systemic lupus erythematosus may be associated. Histological examination and direct immunofluorescence studies reveal nonspecific inflammatory lupus erythematosus changes while results of cryoglobulin and cold agglutinin studies are negative.


oxidized pyrimidine DNA binding

description: Binding to a DNA region containing an oxidized pyrimidine residue.


8-hydroxy-2'-deoxyguanosine DNA binding

description: Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA.


description: Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+.


Spiral Tube of Schchowa

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The portion of the renal tubule located inside the renal cortex between the proximal convoluted tubule and the loop of Henle.


nuclear inner membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane.


nuclear membrane fusion

description: The joining of 2 or more lipid bilayer membranes that surround the nucleus.


nuclear outer membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane.


sperm nuclear envelope removal

description: Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus.


name: nuclear membrane fusion involved in karyogamy

description: The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei.


levamlodipine

The (4S)-enantiomer of amlodipine.


heterochromatin island

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A region of facultative heterochromatin formed dynamically at specific loci in response to environmental signals, independently of RNAi.


name: respiratory system lymphatic vessel smooth muscle

description: A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition].


lymphatic vessel smooth muscle

description: A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition].


inferior pancreaticoduodenal artery

description: The inferior pancreaticoduodenal artery is a branch of the superior mesenteric artery or from its first intestinal branch, opposite the upper border of the inferior part of the duodenum. It courses to the right between the head of the pancreas and duodenum, and then ascends to anastomose with the anterior and posterior superior pancreaticoduodenal artery. It distributes branches to the head of the pancreas and to the descending and inferior parts of the duodenum. [WP,unvetted].


Angelucci syndrome

description: Atopic conjunctivitis that is of relatively short duration and that has a rapid onset.


acute conjunctivitis

description: Acute inflammation of the conjunctiva.


acute contagious conjunctivitis

description: Acute inflammation of the conjunctiva characterized by pink or red color in the eyes.


name: extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration

description: The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells.


name: (Z,E)-alpha- farnesene synthase activity

description: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid.


wing and notum subfield formation

description: The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures.


Pancreatic Serous Adenoma

description: A benign, non-metastasizing, usually cystic epithelial neoplasm arising from the exocrine pancreas.  It is composed of glycogen-rich epithelial cells which produce a watery fluid.  Signs and symptoms include abdominal mass, abdominal pain, nausea, vomiting, and weight loss.


name: Pancreatic Macrocystic Serous Cystadenoma

description: A benign, non-metastasizing epithelial neoplasm arising from the exocrine pancreas.  It is characterized by the presence of a few large cysts and is composed of glycogen-rich epithelial cells which produce a watery fluid.


Pancreatic Solid Serous Adenoma

description: A well-circumscribed serous adenoma that is solid and lacks cystic changes.


name: Von Hippel Lindau Syndrome-Associated Pancreatic Serous Adenoma

description: A serous adenoma that develops in a patient with Von Hippel-Lindau syndrome.  Usually there are multiple serous adenomas present of the macrocystic type.


name: Locally Advanced Gastrointestinal Stromal Tumor

description: Gastrointestinal stromal tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Metastatic Gastrointestinal Stromal Tumor

description: Gastrointestinal stromal tumor which has spread from its original site of growth to another anatomic site.


Advanced Gastrointestinal Stromal Tumor

description: A gastrointestinal stromal tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: mitochondrial complex 1 deficiency, nuclear type 16


name: smooth muscle tissue layer of ejaculatory duct

description: A smooth muscle tissue that is part of a ejaculatory duct.


name: cellular response to N-acetyl-D-glucosamine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus.


name: cellular response to chondroitin 6'-sulfate

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus.


name: metanephric glomerular endothelium development

description: The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros.


name: mesonephric glomerular epithelium development

description: The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros.


Vaginal Blue Nevus

description: A neoplasm that arises from the vagina and is characterized by the proliferation of subepithelial benign dendritic melanocytes.


humeroradial joint

description: A hinge joint between the head of the radius and the capitulum of the humerus.


diiodophenylpyruvate reductase activity

description: Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH.


Charcot-Marie-Tooth disease type 2B

description: Autosomal dominant Charcot-Marie-Tooth disease type 2B (CMT2B) is a severe form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy. CMT2B onset, in the 2nd or 3rd decade, is characterized by ulcerations and infections of feet. Symmetric and distal weakness develops mostly in the legs together with a severe symmetric distal sensory loss, tendon reflexes are only reduced at ankles and foot deformities, including pes cavus or planus and hammer toes, appear in childhood.


PIGA Deficiency

description: An X-linked recessive inherited disorder caused by loss of function mutations in the PIGA gene. It is characterized by deficient GPI-anchor synthesis. Patients may develop somatic paroxysmal nocturnal hemoglobinuria (PNH) or multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2; early infantile epileptic encephalopathy 20; EIEE20).


name: nystagmus 3, congenital, autosomal dominant


name: Chest Pain Along Right Upper Sternal Border

description: The location of the chest pain is along the right upper border of the sternum.


orbitosphenoid-lateral ethmoid joint

description: Joint that articulates the orbitosphenoid cartilage or bone and lateral ethmoid cartilage or bone. Orbitosphenoid-lateral ethmoid joint is paired.


spondylo-ocular syndrome

description: Spondylo-ocular syndrome is a very rare association of spinal and ocular manifestations that is characterized by dense cataracts, and retinal detachment along with generalized osteoporosis and platyspondyly. Mild craniofacial dysphormism has been reported including short neck, large head and prominent eyebrows.


name: neurological muscular channelopathy due to a genetic chloride channel defect


Solid Cystic Hidradenoma

description: A hidradenoma characterized by the presence of solid lobular neoplastic cell proliferations and cystic spaces filled with homogeneous eosinophilic material.


Intraoperative skin injury

description: Damage to the skin during a surgical procedure.


Injury of integument

description: Damage to the skin.


Frostbite

description: An injury to the skin and/or its underlying tissues that results from exposure of the affected area to extreme cold.


Skin Bruise

description: Extravasation of blood into the subcutaneous space.


Traumatic subcutaneous emphysema

description: The infiltration of air into the skin tissue secondary to traumatic tissue disruption.


polyamino carboxylic acid

An amino acid containing one or more nitrogen atoms connected through carbon atoms to one or more carboxy groups.


Acute Thymic Involution

description: The sudden shrinking and/or complete disappearance of the thymus gland; this often happens as a response to a physiologic stressor, such as infection or malnutrition.


regulation of myofibril number

description: Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.


geissoschizine dehydrogenase activity

description: Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + H+ + NADPH.


juvenile open angle glaucoma

description: Juvenile glaucoma (JG) is a rare autosomal dominant open angle glaucoma, characterized by early onset, severe elevation of intra ocular pressure of rapid progression, leading to optic nerve excavation and, when untreated, substantial visual impairment.


glaucoma 1, open angle, O

description: Any open-angle glaucoma in which the cause of the disease is a mutation in the NTF4 gene.


low tension glaucoma

description: A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure.


OPTN-related open angle glaucoma

description: Any open angle glaucoma in which the cause of the disease is a mutation in the OPTN gene.


glaucoma 1, open angle, A

description: Any juvenile glaucoma in which the cause of the disease is a mutation in the MYOC gene.


name: persistent polyclonal B-cell lymphocytosis

description: Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by: chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.


(S)-ethotoin

The (S)-enantiomer of ethotoin.


(R)-ethotoin

The (R)-enantiomer of ethotoin.


HYDANTOIN

An imidazolidinone with oxo groups at position 2 and 4.


imidazolidinone

An imidazolidine containing one or more oxo groups.


platelet-derived growth factor complex

description: A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD).


VEGF-A complex

description: A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase.


name: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol

description: The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine.


Multinodular Adrenal Hyperplasia

description: A subtype of adrenal hyperplasia, based on histopathologic features, in which there are multiple nodules.


cellular response to red light

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.


response to red light

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.


response to photoperiod, red light

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm.


name: response to very low fluence red light stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec.


red light signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.


name: response to low fluence red light stimulus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec.


description: Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA.


Vulvar Alveolar Rhabdomyosarcoma

description: An extremely rare malignant mesenchymal neoplasm of the vulva exhibiting skeletal muscle differentiation with an alveolar pattern.


ovarian lymphoma

description: A lymphoma that affects the ovary. Lymphomatous involvement of the ovary is rare and in approximately half of the cases both ovaries are affected.


name: CYP1B1-related glaucoma with or without anterior segment dysgenesis

description: Any primary congenital glaucoma in which the cause of the disease is a mutation in the CYP1B1 gene.


name: Unresectable Digestive System Mixed Adenoneuroendocrine Carcinoma

description: Digestive system mixed adenoneuroendocrine carcinoma that is not amenable to surgical resection.


hydroxynitrilase activity

description: Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone.


name: aliphatic (S)-hydroxynitrile lyase activity

description: Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide.


name: aromatic (S)-hydroxynitrile lyase activity

description: Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide.


hydroxymandelonitrile lyase activity

description: Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate.


name: aliphatic (R)-hydroxynitrile lyase activity

description: Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide.


name: positive regulation of preblastoderm mitotic cell cycle

description: Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle.


juvenile polymyositis

description: An idiopathic inflammatory myopathy of childhood resulting in muscle weakness.


name: folate:monoatomic anion antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF.


name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol

description: The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter.


name: anaerobic organosilicon metabolic process

description: The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen.


name: protein localization to nuclear inner membrane

description: A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.


name: protein-glutamic acid ligase activity, elongating

description: Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H+ + phosphate.


name: protein-glutamic acid ligase activity, initiating

description: Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H+ + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate.


name: ribosomal protein S6 glutamate-glutamate ligase activity

description: Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate.


name: ribosomal S6-glutamic acid ligase activity

description: Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6.


name: Advanced Pancreatic Neuroendocrine Tumor

description: A pancreatic neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Pancreatic neuroendocrine tumor metastatic

description: A neuroendocrine tumor that arises from the islet cells of the pancreas and has spread to another anatomic site.


name: Advanced Pancreatic Neuroendocrine Tumor G1

description: Pancreatic neuroendocrine tumor G1 that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Metastatic Pancreatic Neuroendocrine Tumor G3

description: Panreatic neuroendocrine tumor G3 that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Pancreatic Neuroendocrine Tumor G3

description: Pancreatic neuroendocrine tumor G3 that has spread from its original site of growth to nearby tissues or lymph nodes.


name: Metastatic Pancreatic Neuroendocrine Tumor G1

description: Pancreatic neuroendocrine tumor G1 that has spread from its original site of growth to another anatomic site.


name: Locally Advanced Pancreatic Neuroendocrine Tumor

description: A pancreatic neuroendocrine tumor that has spread from its original site of growth to nearby tissues or lymph nodes.


ABC-type heme transporter activity

description: Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out).


puerperal infection

description: An infection occurring in puerperium, the period of 6-8 weeks after giving birth.


postpartum psychosis

description: Postpartum psychosis is a rare psychiatric emergency in which symptoms of high mood and racing thoughts (mania), depression, severe confusion, loss of inhibition, paranoia, hallucinations and delusions set in, beginning suddenly in the first two weeks after childbirth. The symptoms vary and can change quickly.


serous cystadenofibroma

description: A benign neoplasm characterized by the presence of cystic structures lined by serous epithelial cells in a fibrotic stroma. Most commonly the primary site is the ovary, but serous cystadenofibromas can occur in the pancreas as well.


uterine corpus apoplectic leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by zones of hemorrhagic infarction surrounded by hypercellular areas. It usually develops in women of childbearing years, particularly those that are pregnant, post-partum, or taking oral contraceptives.


ovarian clear cell adenofibroma

description: An uncommon benign neoplasm of glandular epithelium characterized by the presence of clear or hobnail cells within a dense fibrous stroma.


fibroma of prostate

description: A fibroma that involves the prostate gland.


uterine corpus cellular leiomyoma

description: A morphologic variant of leiomyoma arising from the uterine corpus. It is characterized by a dense cellular infiltrate composed of spindle or round cells with scant cytoplasm and a less obvious interlacing fascicle pattern.


oral fibroma

description: A non-metastasizing oral neoplasm arising from fibrous tissue characterized by the presence of spindle-shaped fibroblasts.


uterine corpus bizarre leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by significant cytologic atypia. The atypical cells are large with pleomophic hyperchromatic nuclei.


uterine corpus dissecting leiomyoma

description: A rare morphologic variant of uterine corpus leiomyoma. Macroscopically, it is characterized by large, fungating, and multinodular neoplasm masses arising from the uterine corpus, and extending into the broad ligament or the peritoneal cavity. Microscopically, it shows neoplastic smooth muscle cells infiltrating the myometrium. The neoplastic cells are arranged in a micronodular pattern. Hydropic changes and increased vascularity are also present.


uterine corpus adenofibroma

description: A usually polypoid, benign neoplasm that arises from the endometrial cavity. It is characterized by the presence of a mesenchymal core component and an epithelial component that forms a lining on the mesenchymal core.


testicular fibroma

description: A benign neoplasm that arises from the testis and is characterized by the presence of fusiform cells and collagenization.


ovarian clear cell cystadenofibroma

description: A benign neoplasm of glandular epithelium characterized by the presence of clear or hobnail cells within a dense fibrous stroma and cystic structures.


cystadenofibroma

description: A benign or borderline neoplasm that arises from the ovaries and the fallopian tubes. It is characterized by the presence of cystic glandular structures and fibrous tissue.


adenofibroma

description: A benign neoplasm characterized by the presence of connective tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, uterine corpus, and cervix. Cases of adenofibroma of the ovary with low grade malignant potential have also been reported.


clear cell adenofibroma

description: A benign neoplasm characterized by the presence of glandular structures which contain clear cells and a fibrotic stroma.


ovarian endometrioid cystadenofibroma

description: A benign neoplasm of the ovary characterized by the presence of cystic structures lined by endometrial-type well-differentiated cells in a fibrotic stroma.


uterine corpus diffuse leiomyomatosis

description: An unusual condition characterized by the presence of numerous small benign smooth muscle neoplasms located throughout the body of the uterus.


rete ovarii cystadenofibroma

description: An exceptionally rare cystadenofibroma that arises from the rete ovarii.


ovarian serous adenofibroma

description: A benign neoplasm of the ovary characterized by the presence of glands with serous epithelial cells in a fibrotic stroma.


uterine corpus lipoleiomyoma

description: A rare morphologic variant of uterine corpus leiomyoma characterized by the presence of scattered islands of mature adipocytes within the smooth muscle neoplasm.


serous adenofibroma

description: A benign adenofibroma characterized by the presence of serous secretory cells and minute cystic spaces filled with watery fluid. A representative example is the ovarian serous adenofibroma. Cases with epithelial atypia described in the ovary lacking stromal invasion are designated as borderline serous adenofibromas and have a low grade malignant potential.


papillary adenofibroma

description: A biphasic polypoid neoplasm characterized by the presence of papillary projections that are lined by epithelial cells and fibrotic stroma.


tendon sheath fibroma

description: A small, slow growing, benign neoplasm arising from the tendon sheaths. The tumor is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation.


fallopian tube serous adenofibroma

description: A rare, benign, asymptomatic neoplasm that arises from the fallopian tube. The majority of cases are incidental findings during operation for an unrelated gynecologic disorder. The tumors are round and solitary and contain connective tissue and papillary or tubular structures lined by serous-type epithelium.


uterine corpus myxoid leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by extensive myxoid degeneration of the neoplasm connective tissue stroma.


uterine corpus epithelioid leiomyoma

description: A morphologic variant of uterine corpus leiomyoma characterized by the presence of round or polygonal epithelioid smooth muscle cells forming clusters.


clear cell cystadenofibroma

description: A benign neoplasm characterized by the presence of cystic glandular and fibrous tissues and clear cells.


calcified aponeurotic fibroma

description: A rare slow-growing benign neoplasm arising from the soft tissues in children. It is a poorly circumscribed tumor characterized by the presence of chondrocyte-like cells, nodular calcification, nuclear palisading, and in some cases osteoclastic giant cells.


ovarian serous cystadenofibroma

description: A benign neoplasm of the ovary characterized by the presence of cystic structures lined by serous epithelial cells in a fibrotic stroma.


fallopian tube cystadenofibroma

description: A rare, benign, asymptomatic neoplasm that arises from the fallopian tube. The tumors are round and solitary and contain connective tissue and cystic structures lined by serous-type epithelium. The majority of cases are incidental findings during operation for an unrelated gynecologic disorder.


name: spastic paraplegia, intellectual disability, nystagmus, and obesity


name: deactivation of mitotic spindle assembly checkpoint

description: A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint.


name: positive regulation of mitotic sister chromatid segregation

description: Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.


name: positive regulation of mitotic spindle elongation

description: Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation.


description: Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling.


name: positive regulation of mitotic spindle elongation (spindle phase three)

description: Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three).


name: negative regulation of chronic inflammatory response to antigenic stimulus

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


carotenoid isomerase activity

description: Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids.


urethral gland

description: Any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine.


female urethral gland

description: An urethral gland that is part of a female urethra.


minor vestibular gland

description: Small mucous glands opening upon the vestibular mucous membrane between the urethral and the vaginal orifice.


name: paraparetic variant of Guillain-Barre syndrome

description: Paraparetic variant of Guillain-Barré syndrome is a rare variant of Guillain-Barré syndrome characterized by isolated leg weakness, areflexia and radicular leg pain that may simulate a cauda equina or spinal cord syndrome. The arms, ocular, facial, and oropharyngeal muscles are spared, and sphincteric function is normal.


olfactory organ

description: An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ.


osphradium

description: The osphradium is the olfactory organ in certain molluscs, linked with the respiration organ. The main function of this is to test incoming water for silt and other possible food particles. It is used by all members of the Genus Conus.


chronic dacryocystitis

description: Chronic form of dacryocystitis.


name: Recurrent Prostate Acinar Adenocarcinoma

description: The reemergence of prostate acinar adenocarcinoma after a period of remission.


Prostate cancer recurrent

description: Prostate carcinoma reemerging after a period of remission.


name: Adenocarcinoma of the prostate recurrent

description: The reemergence of prostate adenocarcinoma after a period of remission.


name: Recurrent Prostate Small Cell Neuroendocrine Carcinoma

description: The reemergence of prostate small cell neuroendocrine carcinoma after a period of remission.


name: Biochemically Recurrent Prostate Carcinoma

description: Increasing prostate-specific antigen (PSA) following prostatectomy or radiation therapy in a patient with a history of localized prostate carcinoma. Signs of metastasis are absent using the currently available scanning technology.


uredinium development

description: The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores.


ocellus pigment metabolic process

description: The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.


ommochrome catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.


ocellus pigment catabolic process

description: The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.


ommochrome biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.


ocellus pigment biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.


ommochrome metabolic process

description: The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.


name: developmental and epileptic encephalopathy, 77


name: multiple congenital anomalies-hypotonia-seizures syndrome 3

description: A rare congenital disorder of glycosylation characterized by neonatal hypotonia, global development delay, developmental regress and severe to profound intellectual disability, infantile onset seizures that are initially associated with febrile episodes with subsequent transition to unprovoked seizures, impaired vision with esotropia and nystagmus, progressive cerebral and cerebellar atrophy, skeletal abnormalities (including brachycephaly, scoliosis, slender long bones, delayed bone age, pectus excavatum and osteopenia), inverted nipples and dysmorphic features including high and narrow forehead, frontal bossing, short nose, depressed nasal bridge, anteverted nares, high palate and wide open mouth consistent with facial hypotonia. Other features may include cardiac abnormalities (such as patent ductus arteriosus, atrial septal defects), urogenital abnormalities (such as nephrocalcinosis, urolithiasis), and low plasma concentration of alkaline phosphatase.


name: multiple congenital anomalies-hypotonia-seizures syndrome 2

description: Any multiple congenital anomalies/dysmorphic syndrome-intellectual disability in which the cause of the disease is a mutation in the PIGA gene.


name: negative regulation of spore-bearing organ development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores.


name: negative regulation of telium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi.


name: negative regulation of aecium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed.


name: negative regulation of sporocarp development involved in sexual reproduction

description: Any process that stops, prevents or reduces the frequency, rate or extent of sporocarp development involved in sexual reproduction.


name: negative regulation of oogonium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes.


name: negative regulation of sporangium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms.


name: negative regulation of conidiophore development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.


name: negative regulation of oomycete sporangium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated.


name: negative regulation of cleistothecium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.


name: negative regulation of basidium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi.


name: negative regulation of zygosporangium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed.


name: negative regulation of ascus development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed.


name: negative regulation of sporangium germination

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination.


name: negative regulation of phialide development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.


name: negative regulation of uredinium development

description: Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores.


receptor clustering activity

description: A protein-protein adaptor that acts as a platform for receptor clustering, often serving to amplify the sensitivity of a signaling response.


cyclin D2-CDK6 complex

description: A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin D3-CDK4 complex

description: A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


cyclin B3-CDK2 complex

description: A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


name: transforming growth factor beta ligand-receptor complex

description: A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand.


cyclin L-CDK11 complex

description: A protein complex consisting of cyclin L and cyclin-dependent kinase 11 (CDK11). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


P-TEFb complex

description: A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T.