name: positive regulation of fatty acid oxidation

description: Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.


protein secretion

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The controlled release of proteins from a cell.


locomotory behavior

description: The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.


muscle tissue development

description: The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.


fatty acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.


Lip Pain

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Painful sensation in the lip.


determination of left/right symmetry

description: The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.


name: phenol-containing compound metabolic process

description: The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.


Crying

category: biolink:Behavior biolink:OntologyClass biolink:ActivityAndBehavior biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


regulation of bone development

description: Any process that modulates the frequency, rate or extent of bone development.


darifenacin

2-[(3S)-1-Ethylpyrrolidin-3-yl]-2,2-diphenylacetamide in which one of the hydrogens at the 2-position of the ethyl group is substituted by a  2,3-dihydro-1-benzofuran-5-yl group. It is a selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, and is used as the hydrobromide salt in the management of urinary incontinence.


name: negative regulation of bone mineralization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.


mitochondrial genome maintenance

description: The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.


melanosome

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.


regulation of protein dephosphorylation

description: Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein.


name: regulation of respiratory gaseous exchange

description: Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.


T cell homeostasis

description: The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


hydroxychloroquine

An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.


name: glycolytic process through fructose-6-phosphate

description: The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.


Irregular menstruation

description: Abnormally high variation in the amount of time between periods.


Panic attack

description: A sudden episode of intense fear in a situation where there is no danger or apparent cause.


ribonucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


cardiac muscle contraction

description: Muscle contraction of cardiac muscle tissue.


SWI/SNF superfamily-type complex

description: A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.


name: positive regulation of adenylate cyclase activity

description: Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.


name: high-density lipoprotein particle clearance

description: The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


name: acute inflammatory response to antigenic stimulus

description: An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.


protein kinase complex

description: A protein complex which is capable of protein kinase activity.


name: regulation of adherens junction organization

description: Any process that modulates the frequency, rate or extent of adherens junction organization.


Depressed Level Of Consciousness

description: A neurologic state characterized by decreased ability to perceive and respond.


viral transcription

description: The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.


name: negative regulation of protein polymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.


regulation of odontogenesis

description: Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.


telencephalic ventricle

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere.


Glycosuria

description: An increased concentration of glucose in the urine.


name: negative regulation of glycoprotein metabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.


compact myelin

description: The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.


name: positive regulation of synaptic transmission

description: Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.


glucan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.


keratinization

description: The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.


protein phosphatase regulator activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Binds to and modulates the activity of a protein phosphatase.


neuroepithelial cell differentiation

description: The process in which epiblast cells acquire specialized features of neuroepithelial cells.


name: voltage-gated potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


protein homotrimerization

description: The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.


carbohydrate transmembrane transport

description: The process in which a carbohydrate is transported across a membrane.


photoreceptor outer segment membrane

description: The membrane surrounding the outer segment of a vertebrate photoreceptor.


monoatomic ion-gated channel activity

description: Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.


name: vascular endothelial growth factor signaling pathway

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


glibenclamide

An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.


name: positive regulation of embryonic development

description: Any process that activates or increases the frequency, rate or extent of embryonic development.


name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

description: An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.


name: mitochondrial calcium ion transmembrane transport

description: The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.


name: response to transforming growth factor beta

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.


amsacrine

A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits  antineoplastic activity.


metallopeptidase activity

description: Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


negative regulation of axon extension

description: Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.


name: negative regulation of natural killer cell mediated immunity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.


methyltestosterone

A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.


cytosolic large ribosomal subunit

description: The large subunit of a ribosome located in the cytosol.


Slurred speech

description: Abnormal coordination of muscles involved in speech.


name: TRIF-dependent toll-like receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


Abnormal erythrocyte production

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


melanocyte differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.


protein depolymerization

description: The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.


vaginitis

description: A non-infectious or infectious inflammatory process affecting the vagina.


chromosome separation

description: The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).


Intracranial hemorrhage

description: Hemorrhage occurring within the skull.


intramolecular transferase activity

description: Catalysis of the transfer of a functional group from one position to another within a single molecule.


name: positive regulation of protein polymerization

description: Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.


retina development in camera-type eye

description: The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.


cell cycle DNA replication

description: The DNA-dependent DNA replication that takes place as part of the cell cycle.


Behcet disease

description: A chronic, relapsing, multisystemic vasculitis characterized by mucocutaneous lesions, as well as articular, vascular, ocular and central nervous system manifestations.


Neurogenic bladder

description: A type of bladder dysfunction caused by neurologic damage. Neurogenic bladder can be flaccid or spastic. Common manifestatios of neurogenic bladder are overflow incontinence, frequency, urgency, urge incontinence, and retention.


name: intraciliary transport involved in cilium assembly

description: The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.


name: negative regulation of erythrocyte differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.


macroautophagy

description: The autophagic process that proceeds via the formation of an autophagosome.


sulfadiazine

A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.


regulation of fatty acid oxidation

description: Any process that modulates the frequency, rate or extent of fatty acid oxidation.


Splenomegaly

description: Abnormal increased size of the spleen.


name: multicellular organismal-level water homeostasis

description: A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.


calcium ion export

description: The directed movement of calcium ion out of a cell or organelle.


ulcerative stomatitis

description: Inflammation of the mouth mucosa associated with the presence of ulcers.


long-chain fatty acid metabolic process

description: The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: regulation of tumor necrosis factor production

description: Any process that modulates the frequency, rate or extent of tumor necrosis factor production.


triprolidine

An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.


name: CD4-positive, alpha-beta T cell activation

description: The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


Petechiae

description: Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae.


name: pyrimidine deoxyribonucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.


blood vessel remodeling

description: The reorganization or renovation of existing blood vessels.


neutral lipid metabolic process

description: The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.


name: transition metal ion transmembrane transporter activity

description: Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.


name: multicellular organismal response to stress

description: Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


description: The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis.


Laryngeal stridor

description: An abnormal high-pitched noisy sound, occurring during inhalation or exhalation caused by the incomplete obstruction in the throat.


myoblast proliferation

description: The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.


Dysarthria

description: Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.


acalculous cholecystitis

description: Inflammation of the gallbladder in the absence of gallstones.


defense response to protozoan

description: Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.


cyclophosphamide

A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.


toxic shock syndrome

description: A rare acute life-threatening systemic bacterial noncontagious illness caused by exotoxins from bacteria of either the Streptococcus pyogenes or Staphylococcus aureus type. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.


myosin filament

description: A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.


exocytic vesicle

description: A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.


name: delayed rectifier potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.


dynein complex

description: Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.


name: negative regulation of transforming growth factor beta receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.


symbiont entry into host cell

description: The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell.


name: positive regulation of guanylate cyclase activity

description: Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.


regulation of cation channel activity

description: Any process that modulates the frequency, rate or extent of cation channel activity.


endoderm development

description: The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.


Golgi lumen

description: The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.


description: Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.


name: Abnormal circulating lipid concentration

description: Any deviation from the normal concentration of a lipid in the blood circulation.


ribosomal large subunit biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.


memory

description: The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).


name: positive regulation of cardiac muscle contraction

description: Any process that increases the frequency, rate or extent of cardiac muscle contraction.


filopodium tip

description: The end of a filopodium distal to the body of the cell.


name: positive regulation of neuron projection development

description: Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


zuclopenthixol

The (Z)-isomer of clopenthixol.


breast fibrocystic disease

description: Fibrosis associated with cyst formation in the breast parenchyma.


name: regulation of synapse structure or activity

description: Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).


regulation of monoatomic ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: negative regulation of gene expression, epigenetic

description: An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation.


embryo implantation

description: Attachment of the blastocyst to the uterine lining.


receptor metabolic process

description: The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


telencephalon cell migration

description: The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.


regulation of protein import

description: Any process that modulates the frequency, rate or extent of protein import.


hexose metabolic process

description: The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.


name: labyrinthine layer blood vessel development

description: The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.


name: aminoacyl-tRNA synthetase multienzyme complex

description: A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.


queuosine metabolic process

description: The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.


name: positive regulation of blood coagulation

description: Any process that activates or increases the frequency, rate or extent of blood coagulation.


name: inner mitochondrial membrane protein complex

description: Any protein complex that is part of the inner mitochondrial membrane.


Roundabout binding

description: Binding to Roundabout (ROBO) receptor, a transmembrane receptor.


dental caries

description: The decay of a tooth, in which it becomes softened, discolored, and/or porous.


benzodiazepine receptor activity

description: Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.


name: regulation of mammary gland epithelial cell proliferation

description: Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation.


name: negative regulation of epidermal growth factor receptor signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.


regulation of hippo signaling

description: Any process that modulates the frequency, rate or extent of hippo signaling.


Eye foreign bodies

description: External material inside the eyeball.


name: nucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.


response to zinc ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.


obstructive jaundice

description: A finding indicating increased bilirubin levels in the blood and urine, due to intrahepatic or extrahepatic obstruction of the biliary system.


phosphate ion transport

description: The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: positive regulation of cyclin-dependent protein kinase activity

description: Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity.


regulation of nitrogen utilization

description: Any process that modulates the frequency, rate or extent of nitrogen utilization.


Skin Pain

description: Painful sensation in the skin.


name: negative regulation of interleukin-17 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


sotalol

A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.


name: negative regulation of molecular function in another organism

description: Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism.


glycogen catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.


cisplatin

A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).


name: dermatan sulfate proteoglycan metabolic process

description: The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


amnionitis

description: Inflammation of the amnion.


pethidine

A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.


Failure to thrive

description: Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.


N-terminal protein myristoylation

description: The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.


Z disc

description: Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.


ethosuximide

A  dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.


name: regulation of toll-like receptor 4 signaling pathway

description: Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway.


kidney failure

description: An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood.


name: negative regulation of lamellipodium assembly

description: Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.


azathioprine

A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.


inner ear development

description: The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.


regulation of leukocyte degranulation

description: Any process that modulates the frequency, rate, or extent of leukocyte degranulation.


Arthritis NOS aggravated

description: Exacerbation of an arthritic condition.


apical cortex

description: The region that lies just beneath the plasma membrane on the apical edge of a cell.


name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

description: Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.


regulation of stem cell differentiation

description: Any process that modulates the frequency, rate or extent of stem cell differentiation.


negative regulation of viral life cycle

description: Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle.


regulation of monocyte chemotaxis

description: Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.


nuclear steroid receptor activity

description: Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.


response to catecholamine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.


neurotransmitter transport

description: The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.


glucosylceramide metabolic process

description: The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative.


name: serine family amino acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.


prazosin

A member of the class of  piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.


mitotic sister chromatid segregation

description: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.


toll-like receptor 4 signaling pathway

description: The series of molecular signals initiated by a ligand binding to toll-like receptor 4.


ceftriaxone

A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.


regulation of phagocytosis

description: Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.


protein heterotetramerization

description: The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.


cardiac septum development

description: The progression of a cardiac septum over time, from its initial formation to the mature structure.


regulation of leukocyte migration

description: Any process that modulates the frequency, rate, or extent of leukocyte migration.


regulation of pentose-phosphate shunt

description: Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.


ear development

description: The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.


adapalene

A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.


name: purine deoxyribonucleoside triphosphate metabolic process

description: The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.


T cell mediated immunity

description: Any process involved in the carrying out of an immune response by a T cell.


skin atrophy

description: The degeneration and thinning of the epidermis and dermis. It is usually a manifestation of aging.


name: signal transduction by p53 class mediator

description: An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein.


protein tyrosine phosphatase activity

description: Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


apical junction complex

description: A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.


ribonucleoprotein granule

description: A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.


ciliary base

description: Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.


name: negative regulation of protein processing

description: Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.


musculoskeletal system disorder

description: A disease involving the musculoskeletal system.


circadian rhythm

description: Any biological process in an organism that recurs with a regularity of approximately 24 hours.


centriole replication

description: The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.


response to lithium ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.


name: negative regulation of hematopoietic progenitor cell differentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.


phagosome maturation

description: A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.


cellular detoxification

description: Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


name: positive regulation of glutamate secretion

description: Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate.


modulation by symbiont of host process

description: The process in which a symbiont organism effects a change in the structure or processes of its host organism.


name: positive regulation of fatty acid biosynthetic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.


midbrain development

description: The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).


name: regulation of toll-like receptor 3 signaling pathway

description: Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway.


regulation of norepinephrine secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.


ritodrine

A 4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol that has (1S,2R)-configuration.


name: protein kinase C-activating G protein-coupled receptor signaling pathway

description: The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).


lipoprotein metabolic process

description: The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


vesicle budding from membrane

description: The evagination of a membrane, resulting in formation of a vesicle.


protein-macromolecule adaptor activity

description: The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.


L-fucose metabolic process

description: The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants.


negative regulation of wound healing

description: Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.


nuclear membrane

description: Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.


name: positive regulation of canonical NF-kappaB signal transduction

description: Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade.


response to type I interferon

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


cysteine-tRNA ligase activity

description: Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).


arm

description: The part of the forelimb extending from the shoulder to the autopod[cjm].


profilin binding

description: Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.


nucleotidyltransferase activity

description: Catalysis of the transfer of a nucleotidyl group to a reactant.


name: positive regulation of cytokine-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.


regulation of cellular respiration

description: Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.


intramolecular oxidoreductase activity

description: Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears.


penicillamine

An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.


Leukocytosis

description: An abnormal increase in the number of leukocytes in the blood.


name: negative regulation of neuron apoptotic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.


establishment of cell polarity

description: The specification and formation of anisotropic intracellular organization or cell growth patterns.


name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


regulation of glomerular filtration

description: Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.


meiotic cell cycle

description: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.


monoatomic anion homeostasis

description: Any process involved in the maintenance of an internal steady state of monoatomic anions within an organism or cell. Monatomic anions (also called simple anions) are anions consisting of exactly one atom.


gatifloxacin

A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.


Reduced visual acuity

description: Diminished clarity of vision.


name: ribonucleoside monophosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.


name: termination of RNA polymerase I transcription

description: A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit.


regulatory ncRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a regulatory non-coding RNA molecule.


mammary gland alveolus development

description: The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.


name: gamma-aminobutyric acid signaling pathway

description: The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.


L-arginine

An L-alpha-amino acid that is the L-isomer of arginine.


L-lysine

An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of L-lysine; major species at pH 7.3.


felypressin

A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is used as a vasoconstrictor in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth.


name: negative regulation of peptidase activity

description: Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.


Ache

description: A dull persistent (usually moderately intense) pain.


name: regulation of epidermal growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.


neural tube formation

description: The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.


synaptic transmission, cholinergic

description: The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


name: regulation of activated T cell proliferation

description: Any process that modulates the frequency, rate or extent of activated T cell proliferation.


name: regulation of osteoclast differentiation

description: Any process that modulates the frequency, rate or extent of osteoclast differentiation.


cardiac muscle cell differentiation

description: The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.


electron transport chain

description: A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.


name: positive regulation of epithelial to mesenchymal transition

description: Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


name: establishment or maintenance of bipolar cell polarity

description: Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns.


name: negative regulation of protein modification by small protein conjugation or removal

description: Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal.


epithelial tube formation

description: The developmental process pertaining to the initial formation of an epithelial tube.


oxygen carrier activity

description: Binding to oxygen and delivering it to an acceptor molecule or a specific location.


T cell selection

description: The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.


name: regulation of double-strand break repair

description: Any process that modulates the frequency, rate or extent of double-strand break repair.


modafinil

A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.


carnitine metabolic process

description: The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


voltage-gated chloride channel activity

description: Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


name: positive regulation of hair follicle cell proliferation

description: Any process that activates or increases the rate or extent of hair follicle cell proliferation.


detection of light stimulus

description: The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.


name: positive regulation of proteolysis involved in protein catabolic process

description: Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process.


name: negative regulation of kidney development

description: Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


hormone binding

description: Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.


nuclear membrane disassembly

description: The controlled breakdown of the nuclear membranes, for example during cellular division.


name: regulation of cellular response to growth factor stimulus

description: Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.


name: regulation of tumor necrosis factor superfamily cytokine production

description: Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.


palmitoyltransferase activity

description: Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.


name: regulation of protein targeting to membrane

description: Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


vesicle docking

description: The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.


name: energy coupled proton transmembrane transport, against electrochemical gradient

description: The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport.


name: regulation of leukocyte mediated cytotoxicity

description: Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.


male gonad development

description: The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.


regulation of pinocytosis

description: Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.


Hematuria

description: The presence of blood in the urine. Hematuria may be gross hematuria (visible to the naked eye) or microscopic hematuria (detected by dipstick or microscopic examination of the urine).


translational termination

description: The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).


name: nicotinamide nucleotide metabolic process

description: The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.


protein heterooligomerization

description: The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.


MKS complex

description: A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.


name: myeloid cell activation involved in immune response

description: A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.


cellular response to hypoxia

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


RNA polymerase complex

description: Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.


name: positive regulation of T cell mediated cytotoxicity

description: Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.


adaptive thermogenesis

description: The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.


G6PD deficiency

description: An X-linked genetic condition caused by alterations in the gene G6PD that result in moderately to severely decreased activity levels of the enzyme glucose-6-phosphate dehydrogenase. Most individuals with G6PD deficiency are asymptomatic. Individuals with G6PD variants that cause G6PD deficiency are at risk for neonatal jaundice. These individuals are also at risk for acute hemolytic anemia in response to certain medication exposures, chemical exposures, infections, or consumption of fava beans.


name: high voltage-gated calcium channel activity

description: Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.


aerobic respiration

description: The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.


name: negative regulation of organelle organization

description: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


name: serine family amino acid metabolic process

description: The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.


selenium binding

description: Binding to a selenium (Se) ion.


name: cellular response to monosaccharide stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus.


spermatid nucleus differentiation

description: The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.


phospholipid transport

description: The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.


name: somatic recombination of immunoglobulin gene segments

description: The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.


Regurgitation

description: Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent.


difenoxin

A piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group.


diphenoxylate

A piperidinecarboxylate ester that is the ethyl ester of difenoxin.


regulation of neural retina development

description: Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


response to L-glutamate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus.


hesperetin

A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.


description: The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


Prolonged PR interval

description: Increased time for the PR interval (beginning of the P wave to the beginning of the QRS complex).


Lethargy

description: A state of disinterest, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating.


Premature ventricular contraction

description: Premature ventricular contractions (PVC) or ventricular extrasystoles are premature contractions of the heart that arise in response to an impulse in the ventricles rather than the normal impulse from the sinoatrial (SA) node.


chloride transmembrane transport

description: The process in which chloride is transported across a membrane.


sterol transport

description: The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


name: negative regulation of phosphorus metabolic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.


name: secondary active organic cation transmembrane transporter activity

description: Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.


Nasal congestion

description: Reduced ability to pass air through the nasal cavity often leading to mouth breathing.


phosphatidylinositol dephosphorylation

description: The process of removing one or more phosphate groups from a phosphatidylinositol.


peripheral vascular disease

description: Any disorder affecting blood flow through the veins or arteries outside of the heart.


name: positive regulation of actin filament depolymerization

description: Any process that activates or increases the frequency, rate or extent of actin depolymerization.


biperiden

A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.


Golgi organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.


name: positive regulation of T cell proliferation

description: Any process that activates or increases the rate or extent of T cell proliferation.


Flu-Like Symptoms

description: Complaints describing a pattern similar to influenza, which may include one or more of the following symptoms: fever, chills, muscle or body aches, cough, sore throat, rhinitis, or fatigue.


loperamide

A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.


cellular response to calcium ion

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.


Gingival bleeding

description: Hemorrhage affecting the gingiva.


viral life cycle

description: A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.


protein acetylation

description: The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


developmental pigmentation

description: The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.


cytosolic ribosome

description: A ribosome located in the cytosol.


clathrin coat assembly

description: The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.


name: NAD-dependent histone H3K9 deacetylase activity

description: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.


Pelvic pain

description: Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones.


name: positive regulation of G2/M transition of mitotic cell cycle

description: Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


mismatched DNA binding

description: Binding to a double-stranded DNA region containing one or more mismatches.


esophagitis

description: An acute or chronic inflammatory disease affecting the esophageal wall.


name: renal system process involved in regulation of blood volume

description: A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.


name: regulation of neurotransmitter secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.


name: reactive nitrogen species metabolic process

description: The chemical reactions and pathways involving a reactive nitrogen species.


tRNA modification

description: The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.


darunavir

An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease  enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.


Rigors

description: Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever.


name: termination of RNA polymerase II transcription

description: A transcription termination process that completes the production of a primary RNA polymerase II transcript.


dUTP metabolic process

description: The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate.


glycosyltransferase activity

description: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).


synovial fluid

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Joint fluid is a transudate of plasma that is actively secreted by synovial cells.


name: right ventricular cardiac muscle tissue morphogenesis

description: The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.


zonula adherens

description: A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.


paraplegia

description: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.


valsartan

A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a  [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits  antihypertensive activity.


Skin ulcer

description: A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat.


Abnormal Laboratory Test Result

description: A laboratory test result that falls outside of the normal, acceptable range.


protein polyglycylation

description: The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid.


hindbrain development

description: The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).


name: response to endoplasmic reticulum stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


lymphocyte migration

description: The movement of a lymphocyte within or between different tissues and organs of the body.


name: negative regulation of leukocyte mediated immunity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.


name: positive regulation of astrocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.


trandolapril

A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.


clathrin-coated vesicle membrane

description: The lipid bilayer surrounding a clathrin-coated vesicle.


lamivudine

A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B.


pure red-cell aplasia

description: A disease characterized by normocytic, normochromic anemia, low hematocrit, reticulocytopenia, and selective erythroid hypoplasia.


phosphoric ester hydrolase activity

description: Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.


mating

description: The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.


name: regulation of sequestering of calcium ion

description: Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


aspiration pneumonia

description: A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper respiratory tract.


name: glandular epithelial cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.


name: positive regulation of response to wounding

description: Any process that activates or increases the frequency, rate or extent of response to wounding.


vitamin binding

description: Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


name: purine nucleoside monophosphate metabolic process

description: The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.


name: negative regulation of epithelial cell apoptotic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.


name: Fc-gamma receptor signaling pathway involved in phagocytosis

description: An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.


diphenhydramine

An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.


pyrimidine nucleoside metabolic process

description: The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


name: regulation of G2/M transition of mitotic cell cycle

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.


vestibular disorder

description: Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.


vein smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds.


cytisine

An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking.


Embolism

description: The blockage of a blood vessel lumen by air or solid material such as blood clot or other tissues (e.g., adipose tissue, cancer cells) that have migrated from another anatomic site.


Laceration

description: A cut or tear in any tissue.


mesoderm morphogenesis

description: The process in which the anatomical structures of the mesoderm are generated and organized.


osteoarthritis

description: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterized by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.


sialadenitis

description: Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front ofthe ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common.


iloprost

A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.


ESCRT complex

description: An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes.


response to monosaccharide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus.


name: anterior/posterior axis specification, embryo

description: The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.


response to ketone

description: A response that results in a state of tolerance to ketone.


mammary gland morphogenesis

description: The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


propafenone

An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.


codeine

A  morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.


segmentation

description: The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.


endocrine hormone secretion

description: The regulated release of a hormone into the circulatory system.


Eosinophilia

description: Abnormal high level of eosinophils in the blood.


protein K11-linked ubiquitination

description: A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.


Diplopia

description: Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.


C-5 sterol desaturase activity

description: Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.


acid secretion

description: The controlled release of acid by a cell or a tissue.


name: negative regulation of sequestering of calcium ion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.


ubiquitin ligase complex

description: A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.


fat cell differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.


aminoacyl-tRNA ligase activity

description: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.


regulation of cell projection assembly

description: Any process that modulates the rate, frequency, or extent of cell projection assembly.


restless legs syndrome

description: A condition that occurs while resting or lying in bed; it is characterized by an irresistible urgency to move the legs to obtain relief from a strange and uncomfortable sensation in the legs.


asenapine

An organic heterotetracyclic compound that is 2,3,3a,12b-tetrahydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole bearing methyl and chloro substituents at positions 2 and 5 respectively.


Inflammation

description: A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.


leukocyte differentiation

description: The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.


triiodothyronine

An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.


myeloid cell development

description: The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.


name: ligand-activated transcription factor activity

description: A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.


negative regulation of cell maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation.


natural killer cell activation

description: The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.


name: regulation of tyrosine phosphorylation of STAT protein

description: Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


genitalia development

description: The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.


cardiac muscle cell contraction

description: The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.


name: G protein-coupled purinergic nucleotide receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process.


monoatomic anion channel activity

description: Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel.


name: negative regulation of bone mineralization involved in bone maturation

description: Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation.


vacuole organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.


Toothache

description: A painful sensation originating from a tooth.


AP-type membrane coat adaptor complex

description: Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa).


S-methyltransferase activity

description: Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.


regulation of cellular senescence

description: Any process that modulates the frequency, rate or extent of cellular senescence.


cell fate specification

description: The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.


phosphatidic acid metabolic process

description: The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.


positive regulation of protein import

description: Any process that activates or increases the frequency, rate or extent of protein import.


name: pyridine-containing compound metabolic process

description: The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof.


organelle assembly

description: The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.


name: Electrocardiogram signs of myocardial ischemia


name: T cell activation involved in immune response

description: The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.


protein stabilization

description: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.


neurotrophin TRK receptor binding

description: Binding to a neurotrophin TRK receptor.


amoxicillin

A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.


cranial nerve II

description: Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA].


name: negative regulation of small GTPase mediated signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.


name: ribonucleoside monophosphate metabolic process

description: The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.


inappropriate ADH syndrome

description: A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.


name: deoxyribonucleoside monophosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.


name: negative regulation of Wnt signaling pathway

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.


cellular response to heat

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.


sulfur amino acid metabolic process

description: The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.


plasma membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.


amyloid-beta binding

description: Binding to an amyloid-beta peptide/protein.


mitochondrial translational initiation

description: The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.


nail

description: A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP].


COPII-coated vesicle budding

description: The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


Heat sensation

category: biolink:PhysiologicalProcess biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


negative regulation of kinase activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.


name: unsaturated fatty acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.


ceramide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.