name: pigment metabolic process involved in developmental pigmentation

description: The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism.


maintenance of lens transparency

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.


mitochondrial RNA 5'-end processing

description: Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.


Peripheral neuropathy aggravated

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


polyphosphate metabolic process

description: The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid.


name: protein tyrosine/threonine phosphatase activity

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.


Painful penile erection

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


name: positive regulation of protein activation cascade

description: Any process that activates or increases the frequency, rate or extent of protein activation cascade.


fat pad development

description: The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue.


description: Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.


name: negative regulation of cardiac muscle contraction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.


Premature Obstetric Labor

description: Regular uterine activity with associated cervical change prior to 37 weeks gestation.


name: positive regulation of response to type II interferon

description: Any process that increases the rate, frequency or extent of a response to type II interferon (interferon-gamma). Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus.


linoleate 13S-lipoxygenase activity

description: Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.


histone mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).


name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

description: Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.


name: positive regulation of response to alcohol

description: Any process that activates or increases the frequency, rate or extent of response to alcohol.


acylglycerol transport

description: The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids.


name: site-specific endodeoxyribonuclease activity, specific for altered base

description: Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks.


name: positive regulation of protein deubiquitination

description: Any process that activates or increases the frequency, rate or extent of protein deubiquitination.


capillary leak syndrome

description: A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.


Clostridium colitis

description: An acute inflammatory disorder of the colon secondary to infection with any species of the bacterial genus Clostridium. Symptoms include acute diarrhea, abdominal pain, and myalgia.


galactolipid metabolic process

description: The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.


congenital arteriovenous fistula

description: An abnormal, epithelial-lined connection between an artery and vein that is present at the time of birth.


lung growth

description: The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.


name: negative regulation of ATP biosynthetic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process.


cellular response to pheromone

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.


name: maintenance of unfolded protein involved in ERAD pathway

description: Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome.


complement component C3a binding

description: Binding to a C3a product of the complement cascade.


name: regulation of smooth muscle cell chemotaxis

description: Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis.


acetylcholine binding

description: Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.


name: phosphatidylinositol 3-kinase regulatory subunit binding

description: Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.


streptobacillary rat-bite fever

description: Streptobacillary rat-bite fever (RBF) is a systemic zoonosis caused by the aerobic gram-negative bacterium Streptobacillus moniliformis and is transmitted to humans through the bites and scratches of infected rats.


pleural disorder

description: A non-neoplastic or neoplastic disorder that affects the pleura. Representative examples include pleural infection, pleural mesothelioma, and pleural solitary fibrous tumor.


name: positive regulation of voltage-gated potassium channel activity

description: Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity.


name: regulation of muscle filament sliding speed

description: Any process that modulates the velocity of muscle filament sliding.


name: lateral sprouting involved in lung morphogenesis

description: The process in which a branch forms along the side of the lung epithelial tube.


exogenous lipid antigen binding

description: Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).


name: regulation of barbed-end actin filament capping

description: Any process that modulates the frequency, rate or extent of barbed-end actin filament capping.


name: negative regulation of DNA catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process.


name: positive regulation of protein localization to synapse

description: Any process that activates or increases the frequency, rate or extent of protein localization to synapse.


response to interleukin-13

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


name: positive regulation of mesenchymal cell apoptotic process

description: Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.


name: chromosome attachment to the nuclear envelope

description: The process in which chromatin is anchored to the nuclear envelope.


DNA integration

description: The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.


microprocessor complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.


name: hepatocyte growth factor receptor binding

description: Binding to an hepatocyte growth factor receptor.


histone H3T6 kinase activity

description: Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3.


ATP transmembrane transporter activity

description: Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other.


name: hemolysis by symbiont of host erythrocytes

description: The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction.


name: positive regulation by virus of viral protein levels in host cell

description: Any process where the infecting virus increases the levels of viral proteins in a cell.


description: The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


lysophosphatidic acid binding

description: Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.


threonine metabolic process

description: The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.


name: atrial cardiac muscle cell to AV node cell communication

description: The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


negative regulation of hypersensitivity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity.


name: glycerol-3-phosphate dehydrogenase (quinone) activity

description: Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.


name: positive regulation of deoxyribonuclease activity

description: Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.


negative regulation of action potential

description: Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.


Vulvar abscess

description: A circumscribed area of pus or necrotic debris in the vulvar region.


intracranial embolism

description: Blocking of a blood vessel in the skull by an embolus which can be a blood clot (thrombus) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with heart diseases. Other non-cardiac sources of emboli are usually associated with vascular diseases.


neurofibroma

description: An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.


name: negative regulation of dopamine secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.


mitochondrial crista

description: Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.


name: modulation of apoptotic process in another organism

description: A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism.


femoral nerve

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The femoral nerve, the largest branch of the lumbar plexus, arises from the ventral divisions of the second, third, and fourth lumbar nerves. It descends through the fibers of the Psoas major, emerging from the muscle at the lower part of its lateral border, and passes down between it and the Iliacus, behind the iliac fascia; it then runs beneath the inguinal ligament, into the thigh, and splits into an anterior and a posterior division. Under the inguinal ligament, it is separated from the femoral artery by a portion of the Psoas major. [WP,unvetted].


metanephric S-shaped body morphogenesis

description: The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros.


name: positive regulation of fat cell proliferation

description: Any process that activates or increases the rate or extent of fat cell proliferation.


ATF1-ATF4 transcription factor complex

description: Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.


name: protein O-linked glycosylation via serine

description: The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine.


neural crest formation

description: The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.


transketolase or transaldolase activity

description: Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor).


name: positive regulation of transcription from RNA polymerase II promoter by glucose

description: Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.


Granulocytosis

description: An increased count of granulocytes in the peripheral blood circulation.


ITP metabolic process

description: The chemical reactions and pathways involving ITP, inosine triphosphate.


name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound.


growth plate cartilage morphogenesis

description: The process in which the anatomical structures of growth plate cartilage are generated and organized.


name: blood vessel endothelial cell fate commitment

description: The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell.


Caustic injury

description: Tissue corrosion or chemical burn.


arylamine N-acetyltransferase activity

description: Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.


name: regulation of the force of heart contraction by cardiac conduction

description: A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled.


axonal spine

description: A spine that originates from the axon, usually from the initial segment.


plasma membrane to endosome transport

description: Transport of a vesicle from the plasma membrane to the endosome.


description: Catalysis of the reaction: (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


name: thyroid hormone transmembrane transporter activity

description: Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.


Tactile hallucination

description: Perception of touch without a tactile stimulus.


cefaloridine

A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.


detection of carbohydrate stimulus

description: The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal.


arthritis, sacroiliac

description: Inflammation of the sacroiliac joint, generally accompanied by lower back pain.


name: positive regulation of dipeptide transmembrane transport

description: Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport.


name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity

description: Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.


asymmetric Golgi ribbon formation

description: The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity.


name: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

description: The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.


Hemodynamic instability

description: A state of hypoperfusion that does not support normal organ perfusion or function. It can include periods of reduced, unstable, or abnormal blood pressure with near syncope, or episodes of syncope.


nuclear estrogen receptor activity

description: Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.


name: maintenance of protein location in extracellular region

description: Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere.


name: regulation of cell chemotaxis to fibroblast growth factor

description: Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor.


name: regulation of T cell tolerance induction

description: Any process that modulates the frequency, rate, or extent of T cell tolerance induction.


regulation of thymocyte migration

description: Any process that modulates the frequency, rate or extent of thymocyte migration.


name: negative regulation of T cell mediated immunity

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.


cervical lymphadenitis

description: Inflammation of the cervical lymph nodes.


prenylcysteine metabolic process

description: The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.


Hemobilia

description: Bleeding into the biliary tree.


negative regulation of vasoconstriction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction.


name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube.


name: positive regulation of T-helper 2 cell activation

description: Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation.


morphogen activity

description: Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.


insecticide metabolic process

description: The chemical reactions and pathways involving insecticides, chemicals used to kill insects.


description: Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.


Paroxysmal ventricular tachycardia

description: Episodes of ventricular tachycardia that have a sudden onset and ending.


asymmetric stem cell division

description: Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity.


transcription corepressor binding

description: Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.


name: endoplasmic reticulum quality control compartment

description: A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.


VCP-NSFL1C complex

description: A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.


(S)-limonene 6-monooxygenase activity

description: Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].


Low Blood Oxygen Saturation

description: A low level of the degree to which oxygen is bound to hemoglobin given as a percentage calculated by dividing the maximum oxygen capacity into the actual oxygen content and multiplying by 100. Oxygen saturation usually is measured using pulse oximetry.


dihydrofolate metabolic process

description: The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.


name: positive regulation of transferrin receptor binding

description: Any process that activates or increases the frequency, rate or extent of transferrin receptor binding.


signal recognition particle binding

description: Binding to a signal recognition particle.


uridine kinase activity

description: Catalysis of the reaction: ATP + uridine = ADP + UMP.


diacylglycerol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.


GDP phosphatase activity

description: Catalysis of the reaction: GDP + H2O = GMP + phosphate.


name: negative regulation of odontogenesis of dentin-containing tooth

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.


protein linear polyubiquitination

description: A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein.


name: negative regulation of mononuclear cell migration

description: Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.


response to prolactin

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation.


name: ciliary neurotrophic factor-mediated signaling pathway

description: The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cerebrospinal fluid leak

description: Discharge of cerebrospinal fluid through a hole through the skull bone most commonly draining from the nose (CEREBROSPINAL FLUID RHINORRHEA) or the ear (CEREBROSPINAL FLUID OTORRHEA).


name: retrograde transport, plasma membrane to Golgi

description: The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.


name: negative regulation of long-term synaptic potentiation

description: Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation.


name: negative regulation of interleukin-6-mediated signaling pathway

description: Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway.


Abnormality of the mouth

description: An abnormality of the mouth.


name: corticotrophin-releasing factor receptor activity

description: Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.


name: positive regulation of anion transmembrane transport

description: Any process that activates or increases the frequency, rate or extent of anion transmembrane transport.


name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.


name: long-chain fatty acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.


name: 'de novo' pyrimidine nucleobase biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.


description: Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.


base-excision repair, AP site formation

description: The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.


name: regulation of skeletal muscle cell differentiation

description: Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.


name: [heparan sulfate]-glucosamine N-sulfotransferase activity

description: Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.


name: symbiont-mediated activation of host programmed cell death

description: A process in which a symbiont gene product activates host programmed cell death, leading to an increase in the frequency, rate or extent of programmed cell death in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Atypical pneumonia

description: Historical term that references a form of pneumonia caused by Mycoplasma pneumoniae, Chlamydophila pneumoniae, or Legionella species.


acetyl-CoA transport

description: The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.


name: negative regulation of chemokine-mediated signaling pathway

description: Any process that decreases the rate, frequency or extent of a chemokine-mediated signaling pathway.


Papulopustular Rash

description: Skin eruption consisting of papules and pustules, most often appearing in the face, scalp, and upper trunk.  It is usually caused by corticosteroids or epidermal growth factor receptor inhibitors.


chondrocalcinosis

description: An acute episode of pain, swelling, and redness, sometimes associated with fever. It is caused by the deposition of calcium pyrophosphate crystals in the joints.


description: Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.


description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.


positive regulation of T cell anergy

description: Any process that activates or increases the frequency, rate, or extent of T cell anergy.


ear malformation

description: An abnormality of the ear.


name: RNA polymerase III transcription regulatory region sequence-specific DNA binding

description: Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.


secretory granule localization

description: Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.


name: pyridoxal phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.


Fanconi-like syndrome

description: A syndrome characterized by pancytopenia, immune deficiency and cutaneous malignancies.


protein localization to cell cortex

description: A process in which a protein is transported to, or maintained in, the cell cortex.


Cerebral atrophy

description: Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum.


Cutis anserina

category: biolink:PhysiologicalProcess biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: ventral trunk neural crest cell migration

description: The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.


establishment of neuroblast polarity

description: The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.


unmethylated CpG binding

description: Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters.


cell communication by chemical coupling

description: The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels.


description: Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.


regulation of hyaluranon cable assembly

description: Any process that modulates the frequency, rate or extent of hyaluranon cable assembly.


pituitary gland infarction

description: Ischemic necrosis of the pituitary gland.


name: mesenchymal cell differentiation involved in renal system development

description: The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state.


diffuse large B-cell lymphoma

description: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.


phosphorylase kinase regulator activity

description: Modulation of the activity of the enzyme phosphorylase kinase.


name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses

description: Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.


autosome

description: Any chromosome other than a sex chromosome.


name: regulation of endothelial tube morphogenesis

description: Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.


neurotrophin p75 receptor binding

description: Binding to a neurotrophin p75 receptor.


description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.


brain segmentation

description: Division of the brain into a series of semi-repetitive parts or segments.


name: regulation of locomotion involved in locomotory behavior

description: Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


Iron deficiency

description: Subnormal concentrations of iron resulting from low iron intake, inefficient iron absorption in the gastrointestinal tract, or increased iron loss.


vitamin D binding

description: Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).


thyroid hormone transport

description: The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


intestinal epithelial cell migration

description: The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.


regulation of sarcomere organization

description: Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


name: regulation of bone mineralization involved in bone maturation

description: Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation.


name: negative regulation of serotonin secretion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.


name: corticosteroid receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by a corticosteroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


name: chromosome passenger complex localization to kinetochore

description: A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis.


inflammatory response to wounding

description: The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.


Preexisting Condition

description: A health condition or medical problem that was diagnosed or treated before a specific date.


name: negative regulation of mitochondrial fusion

description: Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.


RIG-I signaling pathway

description: The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.


schizophreniform disorder

description: A disorder that differs from schizophrenia specifically in total duration (schizophreniform disorder lasts at least 1 month but less than 6 months whereas schizophrenia lasts at least 6 months); schizophreniform disorder also typically causes less impairment in the individual's social and occupational functioning.


detection of endogenous stimulus

description: The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal.


intestine smooth muscle contraction

description: A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.


name: positive regulation of cAMP-dependent protein kinase activity

description: Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.


name: positive regulation of T-helper 1 cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.


nose morphogenesis

description: The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).


aortic valve insufficiency

description: Dysfunction of the aortic valve characterized by incomplete valve closure.


name: secretion by lung epithelial cell involved in lung growth

description: The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development.


calcitonin receptor binding

description: Binding to a calcitonin receptor.


name: regulation of high voltage-gated calcium channel activity

description: Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.


photoreceptor cell morphogenesis

description: The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.


lipopolysaccharide metabolic process

description: The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.


tympanitis

description: An inflammatory disease involving a pathogenic inflammatory response in the tympanic membrane.


name: regulation of telomere maintenance via semi-conservative replication

description: Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA.


Simple renal cyst

description: An isolated cyst of the kidney.


axon target recognition

description: The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.


tricuspid valve morphogenesis

description: The process in which the structure of the tricuspid valve is generated and organized.


name: negative regulation of cholesterol metabolic process

description: Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


name: negative regulation of hydrogen peroxide biosynthetic process

description: Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.


granuloma annulare

description: Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. The most commonly affected areas are the forearms, hands and feet. The lesions associated with granuloma annulare usually resolve without treatment. Strong steroids (applied as a cream or injection) are sometimes used to clear the rash more quickly. Most symptoms will disappear within 2 years (even without treatment), but recurrence is common. The underlying cause of granuloma annulare is unknown.


name: nucleoside:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in).


carbohydrate mediated signaling

description: The series of molecular signals mediated by the detection of carbohydrate.


name: dopamine neurotransmitter receptor activity, coupled via Gs

description: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.


Uterine cyst

description: A closed sack of tissue (cyst) located in the uterus.


name: double-stranded DNA 3'-5' DNA exonuclease activity

description: Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule.


popliteal vein

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The popliteal vein course runs alongside the popliteal artery but carries the blood from the knee joint and muscles in the thigh and calf back to the heart. Its origin is defined by the junction of the posterior tibial vein and anterior tibial vein. It drains the peroneal vein before reaching the knee joint and turns into the femoral vein when leaving the adductor canal (also known as Hunter's canal). The popliteal artery extends from the femoral artery behind the popliteal fossa which is the space behind the knee. [WP,unvetted].


synaptic vesicle clustering

description: The process that results in grouping synaptic vesicles in presynaptic structures.


autonomic ganglion

description: Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.


antimicrobial peptide production

description: The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.


name: positive regulation of sensory perception of pain

description: Any process that activates or increases the frequency, rate or extent of sensory perception of pain.


name: response to Thyroglobulin triiodothyronine

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.


regulation of neutrophil activation

description: Any process that modulates the frequency, rate or extent of neutrophil activation.


name: positive regulation of immature T cell proliferation

description: Any process that activates or increases the frequency, rate or extent of immature T cell proliferation.


terminal web assembly

description: The aggregation, arrangement and bonding together of a set of components to form a terminal web.


histone H3T11 kinase activity

description: Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3.


digestive system neoplasm

description: A neoplasm (disease) that involves the digestive system.


name: purine deoxyribonucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

description: Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.


name: positive regulation of cytoplasmic mRNA processing body assembly

description: Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.


name: negative regulation of rDNA heterochromatin formation

description: Any process that decreases the rate, frequency, or extent of ribosomal DNA heterochromatin formation.


isoleucine-tRNA ligase activity

description: Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+.


name: negative regulation of intestinal phytosterol absorption

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine.


Facial Injuries

description: Trauma to the face.


acute respiratory failure

description: Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock.


prenylcysteine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.


name: positive regulation of B cell apoptotic process

description: Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process.


name: negative regulation of sister chromatid cohesion

description: Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion.


mesendoderm development

description: The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues.


name: miRNA-mediated gene silencing by mRNA destabilization

description: An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.


name: positive regulation of mesoderm development

description: Any process that activates or increases the frequency, rate or extent of mesoderm development.


germinal center formation

description: The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.


bacterial pneumonia

description: Acute infection of the lung parenchyma caused by bacteria (e.g., Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila). Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain.


peptidyl-glycine modification

description: The modification of peptidyl-glycine.


asparaginase activity

description: Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.


name: L-serine transmembrane transporter activity

description: Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid.


dense core granule maturation

description: Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.


histone H3K9 demethylase activity

description: Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein.


name: medial motor column neuron differentiation

description: The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate.


renal system vasculature morphogenesis

description: The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form.


acetyl-L-carnitine

An O-acyl-L-carnitine where the acyl group specified is acetyl. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids.


T cell receptor binding

description: Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells.


name: regulation of single strand break repair

description: Any process that modulates the frequency, rate or extent of single strand break repair.


name: post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

description: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.


name: P-type divalent copper transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out).


name: positive regulation of corticotropin-releasing hormone secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell.


phosphorylase kinase activity

description: Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.


laminin-3 complex

description: A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.


name: Serum Total Iron-Binding Capacity result


Accelerated Growth

description: A finding indicating a faster than normal rate of development.


Scarring

description: A scar refers to a lesion in which wound, burn, or sore has not healed completely and fibrous connective tissue has developed.


name: positive regulation of NAD(P)H oxidase activity

description: Any process that activates or increases the activity of the enzyme NAD(P)H oxidase.


diaphysis

description: Subdivision of long bone which forms the part of the bone between the two epiphyses, excluding the metaphyses[FMA,modified].


name: regulation of histamine secretion by mast cell

description: Any process that modulates the frequency, rate or extent of histamine secretion by mast cell.


Abnormality of eye movement

description: An abnormality in voluntary or involuntary eye movements or their control.


name: positive regulation of monocyte chemotactic protein-1 production

description: Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.


name: regulation of retinal cell programmed cell death

description: Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.


name: negative regulation of transcription by RNA polymerase I

description: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I.


description: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+.


Red man syndrome

description: An abrupt onset drug reaction characterized by a red rash that involves the face, neck, and upper torso.


heme A biosynthetic process

description: The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3.


tachykinin receptor activity

description: Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein.


regulation of macrophage chemotaxis

description: Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.


name: negative regulation of PERK-mediated unfolded protein response

description: Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response.


female breast carcinoma

description: A carcinoma that arises from the breast in females. It is the most common malignant tumor that affects females.


interleukin-18 production

description: The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


D-amino acid transport

description: The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


carnosine metabolic process

description: The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine).


cerebellum vasculature development

description: The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure.


name: positive regulation of chemokine (C-C motif) ligand 5 production

description: Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5.


name: negative regulation of germinal center formation

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation.


name: negative regulation of interleukin-4 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.


name: presynaptic active zone cytoplasmic component

description: A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.


ribonuclease H2 complex

description: A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.


name: regulation of CD8-positive, alpha-beta T cell proliferation

description: Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.


intrahepatic bile duct development

description: The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).


name: spinal cord oligodendrocyte cell fate specification

description: The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.


AIDS dementia complex

description: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)


pyrimidine ribonucleoside binding

description: Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose.


specification of loop of Henle identity

description: The process in which the loop of Henle of the kidney nephron acquires its identity.


amygdala development

description: The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.


uniplex complex

description: A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.


sphingomyelin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.


regulation of metanephros size

description: Any process that modulates the size of a metanephric kidney.


name: protein tyrosine phosphatase activator activity

description: Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.


valine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.


Oppositional

category: biolink:Behavior biolink:OntologyClass biolink:ActivityAndBehavior biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: positive regulation of the force of heart contraction by chemical signal

description: Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.


name: cerebellar Purkinje cell layer maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


aldehyde biosynthetic process

description: The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O.


aryl hydrocarbon receptor binding

description: Binding to an aryl hydrocarbon receptor.


norepinephrine binding

description: Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.


aspartate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.


left lung development

description: The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.


threonine deaminase activity

description: Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4.


common bile duct

description: The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct.


L-arginine transmembrane transport

description: The directed movement of L-arginine across a membrane.


bile acid signaling pathway

description: The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: positive regulation of glucocorticoid receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway.


proximal convoluted tubule development

description: The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule.


gas gangrene

description: A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus clostridium. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.


name: negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.


name: positive regulation of mitochondrial electron transport, NADH to ubiquinone

description: Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.


DSIF complex

description: A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.


response to triglyceride

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus.


name: negative regulation of cardiac muscle adaptation

description: Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.


menstrual cycle phase

description: The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.


sensory perception of touch

description: The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).


hepatoblast differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes.


name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development

description: The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta.


regulation of anterior head development

description: Any process that modulates the frequency, rate or extent of anterior head development.


name: zygotic specification of dorsal/ventral axis

description: The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote.


description: Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate.


extracellular matrix protein binding

description: Binding to a protein that is part of an extracellular matrix.


name: cellular response to corticosterone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.


name: positive regulation of extracellular exosome assembly

description: Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.


congenital mitral valve insufficiency

description: Dysfunction of the mitral valve characterized by incomplete valve closure.


prostatic adenoma

description: Focal benign glandular hyperplasia in the prostate gland.


synaptonemal complex disassembly

description: The controlled breakdown of a synaptonemal complex.


response to sucrose

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.


name: termination of mitochondrial transcription

description: A transcription termination process that completes the production of a primary mitochondrial transcript.


regulation of timing of catagen

description: Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle.


name: positive regulation of mitotic metaphase/anaphase transition

description: Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.


name: positive regulation of translation in response to stress

description: Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.


name: negative regulation of low-density lipoprotein particle clearance

description: Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


name: regulation of chronic inflammatory response to antigenic stimulus

description: Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.


peptide-O-fucosyltransferase activity

description: Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor.


name: positive regulation of isotype switching to IgA isotypes

description: Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes.


GATOR1 complex

description: A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.


sensory perception of sweet taste

description: The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


skeletal muscle fiber adaptation

description: Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.


name: apoptotic process involved in luteolysis

description: The apoptotic process that contributes to luteolysis.


Schwann cell proliferation

description: The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.


protein delipidation

description: The breakage of covalent bonds to detach lipid groups from a protein.


tongue cancer

description: A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas.


Pseudoporphyria

description: A drug-induced photodermatosis characterized by skin fragility, erythema, and the appearance of tense bullae, erosions and scarring in the absence of abnormalities in porphyrin metabolism.


name: G protein-coupled serotonin receptor binding

description: Binding to a metabotropic serotonin receptor.


response to pyrethroid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage.


Action tremor

description: A tremor present when the limbs are active, either when outstretched in a certain position or throughout a voluntary movement.


IgE receptor activity

description: Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


name: transcription initiation at mitochondrial promoter

description: A transcription initiation process that takes place at a promoter on the mitochondrial chromosome.


name: positive regulation of neuromuscular junction development

description: Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.


presynaptic active zone assembly

description: The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.


thyroid gland papillary carcinoma

description: A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance.


androgen binding

description: Binding to an androgen, a male sex hormone.


oligopeptide transport

description: The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


nuclear membrane organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.


spinal nucleus of trigeminal nerve

description: Nucleus extending from the upper spinal cord through the pontine tegmentum that receives sensory inputs from the trigeminal nerve. It is continuous caudally with the dorsal gray matter of the spinal cord.


name: positive regulation of G0 to G1 transition

description: A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase.


name: positive regulation of amyloid-beta formation

description: Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.


acetylcholinesterase activity

description: Catalysis of the reaction: acetylcholine + H2O = choline + acetate.


female meiosis II

description: The cell cycle process in which the second meiotic division occurs in the female germline.


epithelial-mesenchymal cell signaling

description: Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted.


name: regulation of calcium ion-dependent exocytosis of neurotransmitter

description: Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter.


fatty acyl-[ACP] hydrolase activity

description: Catalysis of the reaction: a fatty acyl-[ACP] + H2O = a fatty acid + H+ + holo-[acyl-carrier protein].


name: calcium:sodium antiporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).


name: methylenetetrahydrofolate dehydrogenase (NADP+) activity

description: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.


plasma membrane raft assembly

description: The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft.


name: substrate-dependent cell migration, cell attachment to substrate

description: The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions.


lipoic acid

The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.


Recurrent tumor

description: The reemergence of a neoplasm after a period of remission.


name: negative regulation of intestinal cholesterol absorption

description: Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.


t-UTP complex

description: A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.


name: negative regulation of heterotypic cell-cell adhesion

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.


ophthalmic artery

description: The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified].


pyruvate transport

description: The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


Assault

description: A physical attack.


polyprenol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.


sensory perception of sour taste

description: The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.


name: arterial endothelial cell fate commitment

description: The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell.


Tie signaling pathway

description: The series of molecular signals initiated by an angiopoietin binding to the Tie receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


name: Abnormality of peripheral nervous system electrophysiology

description: An abnormality of the function of the electrical signals with which peripheral nerve cells communicate with each other or with muscles.


EARP complex

description: A quatrefoil tethering complex required for endocytic recycling.


name: regulation of systemic arterial blood pressure by endothelin

description: The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.


cortisol metabolic process

description: The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.


response to prostaglandin D

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus.


temperature-gated ion channel activity

description: Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).


name: slow-twitch skeletal muscle fiber contraction

description: A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.


positive regulation of meiosis I

description: Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.


insulin receptor complex

description: A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.


name: phosphatidylinositol phosphate 4-phosphatase activity

description: Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate.


wax metabolic process

description: The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids.


name: regulation of postsynaptic density protein 95 clustering

description: Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering.


name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

description: Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.


base conversion or substitution editing

description: Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s).


thiosulfate sulfurtransferase activity

description: Catalysis of the reaction: hydrogen cyanide + thiosulfate = H+ + sulfite + thiocyanate.


name: cellular response to Thyroglobulin triiodothyronine

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus.


name: glycine:sodium symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in).


mitochondrial tRNA processing

description: The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion.


name: positive regulation of establishment of endothelial barrier

description: Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier.


regulation of heart induction

description: Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.


name: Accident while engaged in household activity


name: negative regulation of neutrophil differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation.


name: regulation of cholangiocyte apoptotic process

description: Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process.


name: semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis

description: Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis.


membrane raft assembly

description: The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.


phosphatidic acid binding

description: Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.


name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

description: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor.


phenylalanine 4-monooxygenase activity

description: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.


Hand pain

description: An unpleasant sensation characterized by physical discomfort localized to the hand.


name: negative regulation of cholesterol storage

description: Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


Atg12-Atg5-Atg16 complex

description: A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.


involuntary skeletal muscle contraction

description: A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control.


name: regulation of cardiac muscle hypertrophy in response to stress

description: Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.


Enlarged tonsils

description: Increase in size of the tonsils, small collections of lymphoid tissue facing into the aerodigestive tract on either side of the back part of the throat.


name: regulation of cell migration involved in somitogenic axis elongation

description: Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation.


dopamine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.


maintenance of DNA repeat elements

description: Any process involved in sustaining the fidelity and copy number of DNA repeat elements.


name: negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

description: Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning.


Purulent sputum

description: Sputum contains pus.


name: purine ribonucleoside bisphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar.


vestibular reflex

description: A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.


interferon receptor activity

description: Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


regulation of amyloid-beta formation

description: Any process that modulates the frequency, rate or extent of amyloid-beta formation.


name: establishment or maintenance of cytoskeleton polarity

description: Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.


name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.


description: A myelodysplastic syndrome characterized by the presence of 5-19% myeloblasts in the bone marrow or 2-19% blasts in the peripheral blood. It includes two categories: myelodysplastic syndrome with excess blasts-1 and myelodysplastic syndrome with excess blasts-2.


name: purine nucleoside diphosphate catabolic process

description: The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.


sulfurtransferase activity

description: Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).


farnesyltranstransferase activity

description: Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.


Cul2-RING ubiquitin ligase complex

description: A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


name: Fetus affected by placental transfer of anticonvulsant


epinephrine transport

description: The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: pyrimidine deoxyribonucleoside metabolic process

description: The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).


name: cytokine production involved in immune response

description: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.


name: regulation of renin secretion into blood stream

description: Any process that modulates the frequency, rate or extent of renin secretion into blood stream.


steroid 11-beta-monooxygenase activity

description: Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.


name: determination of left/right asymmetry in lateral mesoderm

description: The establishment of the lateral mesoderm with respect to the left and right halves.


regulation of glial cell migration

description: Any process that modulates the frequency, rate or extent of glial cell migration.


name: negative regulation of double-strand break repair via nonhomologous end joining

description: Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining.


name: mitochondrial outer membrane translocase complex assembly

description: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.


name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity

description: Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.


description: Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.


regulation of dipeptide transport

description: Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


H3 histone acetyltransferase complex

description: A multisubunit complex that catalyzes the acetylation of histone H3.