facial paralysis

description: Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. facial nerve diseases generally results in generalized hemifacial weakness. neuromuscular junction diseases and muscular diseases may also cause facial paralysis or paresis.


acylglycerol metabolic process

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.


name: positive regulation of sister chromatid cohesion

description: Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion.


myotube cell development

description: The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.


response to starvation

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.


name: positive regulation of vitamin D receptor signaling pathway

description: Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity.


cullin-RING ubiquitin ligase complex

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


maintenance of location

description: Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.


sprouting angiogenesis

description: The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.


nuclear export

description: The directed movement of substances out of the nucleus.


amino acid transport

description: The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


T cell costimulation

description: The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.


protein acetyltransferase complex

description: A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule.


name: signal transduction in absence of ligand

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.


name: odontogenesis of dentin-containing tooth

description: The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.


Lupus-like syndrome

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


arginine catabolic process

description: The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


name: positive regulation of DNA metabolic process

description: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.


glial cell development

description: The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


response to UV

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.


vaginal cancer

description: A primary or metastatic malignant neoplasm involving the vagina. Representative examples include carcinomas and sarcomas.


endocrine system

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.


name: protection from non-homologous end joining at telomere

description: A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse.


name: nucleoside triphosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.


response to water

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.


propofol

A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.


name: SRP-dependent cotranslational protein targeting to membrane

description: The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.


virus receptor activity

description: Combining with a virus component and mediating entry of the virus into the cell.


calcium channel inhibitor activity

description: Binds to and stops, prevents, or reduces the activity of a calcium channel.


regulation of humoral immune response

description: Any process that modulates the frequency, rate, or extent of a humoral immune response.


stem cell development

description: The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.


regulation of DNA recombination

description: Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.


cis-Golgi network

description: The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.


name: positive regulation of circadian sleep/wake cycle, sleep

description: Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.


ameboidal-type cell migration

description: Cell migration that is accomplished by extension and retraction of a pseudopodium.


positive regulation of fever generation

description: Any process that activates or increases the frequency, rate, or extent of fever generation.


morphogenesis of an endothelium

description: The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.


estramustine

A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.


pigment metabolic process

description: The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.


Blurred vision

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Lack of sharpness of vision resulting in the inability to see fine detail.


name: proximal/distal pattern formation involved in nephron development

description: The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end).


RNA polymerase core enzyme binding

description: Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.


name: Left ventricular ejection fraction decreased


cochlear duct of membranous labyrinth

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP].


axon terminus

description: Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.


name: negative regulation of reactive oxygen species metabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.


chemorepellent activity

description: Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.


hormone receptor binding

description: Binding to a receptor for a hormone.


acyl-CoA dehydrogenase activity

description: Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].


Pedal edema

description: An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg.


platelet alpha granule membrane

description: The lipid bilayer surrounding the platelet alpha granule.


conivaptan

The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).


atorvastatin

A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.


name: negative regulation of lymphocyte activation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.


sterol metabolic process

description: The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.


name: negative regulation of cell-cell adhesion

description: Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.


phospholipid transporter activity

description: Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.


terbinafine

A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.


postsynaptic membrane

description: A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.


angioedema

description: Swelling involving the deep dermis, subcutaneous, or submucosal tissues, representing localized edema. Angioedema often occurs in the face, lips, tongue, and larynx.


nitrofurantoin

An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.


cerebellum development

description: The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.


name: catecholamine uptake involved in synaptic transmission

description: The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


posaconazole

An N-arylpiperazine that consists of piperazine carrying two 4-substituted phenyl groups at positions 1 and 4. A triazole antifungal drug.


Bloody diarrhea

description: Passage of many stools containing blood.


name: negative regulation of response to external stimulus

description: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.


monosaccharide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.


monoatomic cation homeostasis

description: Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.


tinidazole

1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group.  It is used as an antiprotozoal, antibacterial agent.


transcription regulator complex

description: A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.


leukocyte mediated immunity

description: Any process involved in the carrying out of an immune response by a leukocyte.


name: branching involved in blood vessel morphogenesis

description: The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.


serine-type peptidase activity

description: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


epithelial cell fate commitment

description: The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell.


name: chlorinated hydrocarbon metabolic process

description: The chemical reactions and pathways involving chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms.


fibronectin binding

description: Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.


regulation of mRNA processing

description: Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.


name: transforming growth factor beta receptor binding

description: Binding to a transforming growth factor beta receptor.


name: regulation of type I interferon-mediated signaling pathway

description: Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway.


double-strand break repair

description: The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.


protein-DNA complex disassembly

description: The disaggregation of a protein-DNA complex into its constituent components.


trans-Golgi network

description: The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.


amnestic disorder

description: Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories.


glomerular mesangium development

description: The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus.


photoperiodism

description: Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.


name: nuclear-transcribed mRNA catabolic process

description: The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.


olfactory nerve

description: Nerve that carries information from the olfactory epithelium to the olfactory bulb[Butler and Hodos].


opsonin binding

description: Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.


nucleosome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.


name: spinal cord motor neuron differentiation

description: The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


mesenchyme development

description: The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.


cellular aldehyde metabolic process

description: The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.


organic hydroxy compound transport

description: The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.


blastocyst development

description: The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.


leukocyte cell-cell adhesion

description: The attachment of a leukocyte to another cell via adhesion molecules.


nephron tubule development

description: The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney.


angle-closure glaucoma

description: The sudden increase of intraocular pressure, resulting in pain and an abrupt decrease in visual acuity.


glycosylceramide metabolic process

description: The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group.


name: positive regulation of T cell differentiation

description: Any process that activates or increases the frequency, rate or extent of T cell differentiation.


transcription repressor complex

description: A protein complex that possesses activity that prevents or downregulates transcription.


4 iron, 4 sulfur cluster binding

description: Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.


floxuridine

A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.


name: regulation of potassium ion transmembrane transporter activity

description: Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity.


sodium lauryl sulfate

An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.


name: negative regulation of endothelial cell migration

description: Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.


Emotional Distress

description: Disturbed mental state characterized by moodiness, irritability, agitation, anxiety, and/or depression resulting from physical or mental stress.


carboxylic acid transport

description: The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).


Epistaxis

description: Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.


tubulin binding

description: Binding to monomeric or multimeric forms of tubulin, including microtubules.


cromoglicic acid

A  dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer.


Hemoptysis

description: Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.


mitral valve morphogenesis

description: The process in which the structure of the mitral valve is generated and organized.


morphogenesis of an epithelial sheet

description: The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.


chlorhexidine

A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.


phagophore assembly site

description: Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.


oxidoreductase activity

description: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.


ethotoin

An imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective.


primidone

A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an  anticonvulsant for treatment of various types of seizures.


post-Golgi vesicle-mediated transport

description: The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.


bHLH transcription factor binding

description: Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.


name: transmembrane receptor protein tyrosine kinase activity

description: Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.


myenteric nerve plexus

description: One of two ganglionated neural networks which together form the enteric nervous system. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility.


response to calcium ion

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.


L-carnitine

The (R)-enantiomer of carnitine.


protein O-linked mannosylation

description: The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.


lamellipodium

description: A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.


name: glial cell-derived neurotrophic factor receptor activity

description: Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


primary miRNA binding

description: Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.


name: regulation of MHC class II biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.


name: negative regulation of protein-containing complex assembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.


name: regulation of animal organ morphogenesis

description: Any process that modulates the frequency, rate or extent of animal organ morphogenesis.


cartilage condensation

description: The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.


name: low-density lipoprotein particle binding

description: Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.


JUN kinase activity

description: Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.


name: negative regulation of interleukin-2 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.


striatum development

description: The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.


UDP phosphatase activity

description: Catalysis of the reaction: UDP + H2O = UMP + phosphate.


cervicitis

description: An acute or chronic inflammatory process that affects the cervix. Causes include sexually transmitted diseases and bacterial infections. Clinical manifestations include abnormal vaginal bleeding and vaginal discharge.


name: cellular response to glucocorticoid stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.


protein kinase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a protein kinase.


diverticulitis

description: An infection that develops in the diverticula of the intestinal tract. Signs and symptoms include abdominal pain, fever, and leukocytosis.


Prolonged QT interval

description: Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).


fatty liver disease

description: A reversible condition wherein large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis.


mitochondrial outer membrane

description: The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.


droperidol

An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.


Dyssynergia

description: A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts.


trabectedin

A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.


neutropenia

description: A decrease in the number of neutrophils found in the blood.


name: negative regulation of nucleocytoplasmic transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.


name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

description: Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.


name: positive regulation of mast cell activation

description: Any process that activates or increases the frequency, rate, or extent of mast cell activation.


cerebral infarction

description: An ischemic condition of the brain, producing a persistent focal neurological deficit in the area of distribution of the cerebral arteries.


name: positive regulation of telomerase activity

description: Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


name: positive regulation of peptidyl-threonine phosphorylation

description: Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


iodixanol

A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.


hydroxyapatite binding

description: Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin.


regulation of interleukin-13 production

description: Any process that modulates the frequency, rate, or extent of interleukin-13 production.


levodopa

An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease


synaptic vesicle

description: A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.


fascia adherens

description: A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.


name: regulation of mitochondrial membrane potential

description: Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


slit diaphragm

description: A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.


foscarnet

Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.


description: The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.


polycythemia

description: Abnormally high mass or concentration of red blood cells in the blood, either due to an increase in erythropoiesis or a decrease in plasma volume.


protein polyufmylation

description: Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain.


name: extracellular matrix structural constituent conferring compression resistance

description: A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.


osteoclast differentiation

description: The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.


camera-type eye development

description: The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.


name: regulation of photoreceptor cell differentiation

description: Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.


name: positive regulation of myeloid leukocyte mediated immunity

description: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.


Drug Eruptions

description: An eruption in the skin due to exposure to a pharmacologic substance.


Photophobia

description: Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.


endothelium development

description: The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.


spinal cord patterning

description: The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord.


anxiety disorder

description: A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety.


fat-soluble vitamin metabolic process

description: The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.


cysteine-type peptidase activity

description: Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


mismatch repair complex

description: Any complex formed of proteins that act in mismatch repair.


single-stranded RNA binding

description: Binding to single-stranded RNA.


extrinsic component of plasma membrane

description: The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


phototoxic dermatitis

description: Dermatitis caused or precipitated by exposure to ultraviolet sunlight, or by mediating phototoxic or photoallergic material in response to ultraviolet sunlight.


Notch binding

description: Binding to a Notch (N) protein, a surface receptor.


embryonic appendage morphogenesis

description: The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.


ovarian cyst

description: A cyst that arises from the ovary. Representative examples include simple, complex, corpus luteum, and endometrioid cysts. Symptoms include pelvic and abdominal pain and irregular periods.


glucosylceramide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.


regulation of cell division

description: Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.


asparagine metabolic process

description: The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid.


Hypercholesterolemia

description: An increased concentration of cholesterol in the blood.


cardiac conduction

description: Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.


name: positive regulation of intracellular transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.


name: cysteine-type endopeptidase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase.


hyperpigmentation of the skin

description: Darkening of the skin due to excessive melanin deposition. Causes include skin injuries, pregnancy, eczema, and Addison disease.


serine phosphorylation of STAT protein

description: The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


C-fiber

description: The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated.


fluconazole

A member of the class of  triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.


Female sexual dysfunction

description: A problem occurring during any phase of the female sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity


name: positive regulation of calcium ion transport

description: Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


protein targeting to ER

description: The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.


trigeminal ganglion development

description: The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.


in utero embryonic development

description: The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.


cerebellar mossy fiber

description: An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations.


cellular response to interleukin-4

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.


response to hyperoxia

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.


cellular response to lipopolysaccharide

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.


orphenadrine

A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.


hippo signaling

description: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.


Gemini of coiled bodies

description: Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA).


liposaccharide metabolic process

description: The chemical reactions and pathways involving liposaccharide.


glaucoma

description: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.


actin nucleation

description: The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.


name: TRAM-dependent toll-like receptor 4 signaling pathway

description: The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


glutamine metabolic process

description: The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.


Hypernatremia

description: An abnormally increased sodium concentration in the blood.


ribosome assembly

description: The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.


positive regulation of heart rate

description: Any process that activates or increases the frequency or rate of heart contraction.


name: positive regulation of sodium ion transmembrane transporter activity

description: Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.


name: nucleotide-binding oligomerization domain containing 2 signaling pathway

description: The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.


locomotory exploration behavior

description: The specific movement from place to place of an organism in response to a novel environment.


virion attachment to host cell

description: The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.


sulfur compound metabolic process

description: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.


collagen catabolic process

description: The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.


retina homeostasis

description: A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.


centrosome separation

description: The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


pigment accumulation

description: The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus.


cochlea

description: The spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. [WP,modified].


regulation of extent of cell growth

description: Any process that modulates the extent of cell growth.


name: positive regulation of cerebellar granule cell precursor proliferation

description: The process that activates or increases the rate or extent of granule cell precursor proliferation.


name: regulation of Golgi to plasma membrane protein transport

description: Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.


nitrogen compound transport

description: The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


acetyl-CoA hydrolase activity

description: Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+.


cellular response to estrogen stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.


name: protein transmembrane import into intracellular organelle

description: The directed movement of proteins into an intracellular organelle, across a membrane.


name: DNA replication-dependent chromatin assembly

description: The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation.


name: solute:proton symporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).


name: positive regulation of peptidyl-serine phosphorylation of STAT protein

description: Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


tRNA wobble uridine modification

description: The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.


biogenic amine biosynthetic process

description: The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.


Pharyngalgia

description: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the throat.


cartilage development

description: The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


name: homologous chromosome pairing at meiosis

description: The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.


calcium-dependent phospholipid binding

description: Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.


name: positive regulation of microtubule polymerization or depolymerization

description: Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.


name: cellular response to amino acid stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.


name: negative regulation of ion transmembrane transporter activity

description: Any process that stops or reduces the activity of an ion transporter.


regulation of chromatin organization

description: Any process that modulates the frequency, rate or extent of chromatin organization.


homeostasis of number of cells

description: Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.


chondrocyte development

description: The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.


negative regulation of growth

description: Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.


DNA-directed RNA polymerase complex

description: A protein complex that possesses DNA-directed RNA polymerase activity.


pigment granule localization

description: Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell.


MAPK cascade

description: An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.


Virilization

description: The development of normal male puberty due to testosterone effect or the abnormal development of male secondary sexual characteristics in children and females due to excessive androgens.


regulation of fibroblast proliferation

description: Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.


name: negative regulation of ubiquitin-dependent protein catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


relaxation of muscle

description: A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain.


name: regulation of collagen metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


lactation

description: The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.


Blood Alkaline Phosphatase Increased

description: A laboratory test result which indicates an increased level of alkaline phosphatase in a biological specimen.


name: hematopoietic progenitor cell differentiation

description: The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.


ribonucleoprotein complex binding

description: Binding to a complex of RNA and protein.


monosaccharide transmembrane transport

description: The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.


name: regulation of osteoblast differentiation

description: Any process that modulates the frequency, rate or extent of osteoblast differentiation.


name: regulation of nucleotide biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.


nucleoside metabolic process

description: The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).


cytoplasmic microtubule

description: Any microtubule in the cytoplasm of a cell.


Irritability

description: A proneness to anger, i.e., a tendency to become easily bothered or annoyed.


name: DNA double-strand break processing involved in repair via single-strand annealing

description: The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing.


cellular response to type II interferon

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.


cellular response to nutrient levels

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


penis

description: An intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination.


animal organ regeneration

description: The regrowth of a lost or destroyed animal organ.


detection of abiotic stimulus

description: The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.


tooth disorder

description: A disease involving the calcareous tooth.


name: positive regulation of mitotic cell cycle phase transition

description: Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition.


response to interferon-alpha

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.


regulation of tube size

description: Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes.


trabecula morphogenesis

description: The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


Hirschsprung disease

description: Hirschsprung disease (HSCR) is a congenital intestinal motility disorder that is characterized by signs of intestinal obstruction due to the presence of an aganglionic segment of variable extent in the terminal part of the colon.


GTPase activity

description: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.


name: regulation of endothelial cell proliferation

description: Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.


vesicle coating

description: A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination.


almotriptan

An indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position.


Somatic sensory dysfunction

description: An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing.


alpha-beta T cell activation

description: The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


transferrin transport

description: The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


translation release factor activity

description: Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.


clathrin-coated pit

description: A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.


response to methotrexate

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


name: purine ribonucleoside monophosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.


name: regulation of calcium ion transport into cytosol

description: Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.


name: negative regulation of cellular catabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


name: neuromuscular process controlling balance

description: Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.


nitisinone

A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.


cancer

description: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas.


name: regulation of monoatomic ion transmembrane transport

description: Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.


aciclovir

An oxopurine that is  guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.


limb morphogenesis

description: The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.


phospholipid binding

description: Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.


mRNA export from nucleus

description: The directed movement of mRNA from the nucleus to the cytoplasm.


methylglyoxal catabolic process

description: The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.


name: positive regulation of filopodium assembly

description: Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.


endocardial cushion development

description: The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


name: regulation of mitochondrion organization

description: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.


name: heparan sulfate proteoglycan biosynthetic process

description: The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.


neuron projection terminus

description: The specialized, terminal region of a neuron projection such as an axon or a dendrite.


name: A-type (transient outward) potassium channel activity

description: Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.


name: G protein-coupled dopamine receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.


germ cell development

description: The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.


name: cellular response to tumor necrosis factor

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.


basilar artery insufficiency

description: A syndrome which occurs as a result of the occlusion of the basilar artery. It may be caused by atherosclerosis, embolism or hemorrhage. Clinical signs include dizziness, headache, vomiting, hemiparesis or hemiplegia, dysarthria, dysphagia, blurred vision and loss of consciousness. The clinical course is variable and is dependent upon the extent of the occlusion and the location of the clot along the basilar artery which determines the resultant neurologic impairment. Prognosis is dismal in cases where a complete occlusion occurs with rapid deterioration of neurological function.


auranofin

An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally for the treatment of active progressive rheumatoid arthritis.


neuropil

description: A cluster of neurites that is part of a nervous system and forms a network of dendrites and axons where synapses are present and in which neuronal somata do not occur.


carbon-oxygen lyase activity

description: Catalysis of the breakage of a carbon-oxygen bond.


regulation of mitotic nuclear division

description: Any process that modulates the frequency, rate or extent of mitosis.


name: positive regulation of lymphocyte differentiation

description: Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.


dTTP metabolic process

description: The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate.


type 4 melanocortin receptor binding

description: Binding to a type 4 melanocortin receptor.


pallium development

description: The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.


name: detection of chemical stimulus involved in sensory perception of smell

description: The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal.


purine nucleoside metabolic process

description: The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).


optic nerve disorder

description: A non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve).


transcription elongation factor complex

description: Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.


chloroprocaine

Procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding.


sodium ion binding

description: Binding to a sodium ion (Na+).


phosphatidylcholine metabolic process

description: The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.


regulation of sister chromatid cohesion

description: Any process that modulates the frequency, rate or extent of sister chromatid cohesion.


positive regulation of DNA repair

description: Any process that activates or increases the frequency, rate or extent of DNA repair.


inner ear morphogenesis

description: The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.


dexfenfluramine

The S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects.


cytoplasmic ribonucleoprotein granule

description: A ribonucleoprotein granule located in the cytoplasm.


mezlocillin

A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.


name: natural killer cell lectin-like receptor binding

description: Binding to a lectin-like natural killer cell receptor.


Lassitude

description: Physical or mental fatigue.


regeneration

description: The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).


actin cytoskeleton

description: The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.


name: regulation of protein localization to nucleus

description: Any process that modulates the frequency, rate or extent of protein localization to nucleus.


developmental cell growth

description: The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.


muscular atrophy

description: The loss of muscle tissue due to inactivity or disease.


branch elongation of an epithelium

description: The growth process in which a branch increases in length from its base to its tip.


GABA receptor binding

description: Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.


enflurane

An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.


long-term synaptic potentiation

description: A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.


herpes simplex infectious disease

description: A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)


purine ribonucleotide metabolic process

description: The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


interleukin-1 beta production

description: The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


developmental growth

description: The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.


name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

description: Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.


name: regulation of canonical Wnt signaling pathway

description: Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


name: negative regulation of cell cycle phase transition

description: Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition.


iron-sulfur cluster assembly

description: The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.


ribosome biogenesis

description: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.


Anger

category: biolink:Behavior biolink:OntologyClass biolink:ActivityAndBehavior biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


umbilical vein

description: The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. [WP,unvetted].


name: regulation of type II interferon production

description: Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


name: regulation of alpha-beta T cell proliferation

description: Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation.


dextropropoxyphene

The (1S,2R)-(+)-diastereoisomer of propoxyphene.


metabolic acidosis

description: Increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock.


name: RNA polymerase II core promoter sequence-specific DNA binding

description: Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.


endocrine process

description: The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.


regulation of ligase activity

description: Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.


terbutaline

A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.


dexamfetamine

A 1-phenylpropan-2-amine that has S configuration.


axonogenesis involved in innervation

description: The neurite development process that generates a long process of a neuron, as it invades a target tissue.


axo-dendritic transport

description: The directed movement of organelles or molecules along microtubules in neuron projections.


lipid droplet organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.


Vitreous floaters

description: Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humor, which is normally transparent.


response to unfolded protein

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.


panophthalmitis

description: Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture.


DNA replication checkpoint signaling

description: A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.


lincomycin

A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.


name: ethanolamine-containing compound metabolic process

description: The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it.


name: negative regulation of cytokine production

description: Any process that stops, prevents, or reduces the rate of production of a cytokine.


response to carbon monoxide

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus.


cellular response to glucose starvation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.


tricarboxylic acid metabolic process

description: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).


name: negative regulation of meiotic nuclear division

description: Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.


Personality changes

description: An abnormal shift in patterns of thinking, acting, or feeling.


U4 snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of a U4 snRNA molecule.


cefaclor

A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.


amino acid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.


fallopian tube

description: Initial section of the oviduct through which the ova pass from the ovary to the uterus.


name: positive regulation of cell cycle G2/M phase transition

description: Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.


name: nucleoside monophosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.


Fibrosis

description: The formation of fibrous tissue.


axoneme

description: The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.


nafcillin

A penicillin in which the substituent at position 6 of the penam ring is a (2-ethoxy-1-naphthoyl)amino group.


name: positive regulation of mammary gland involution

description: Any process that activates or increases the frequency, rate or extent of mammary gland involution.


regulation of potassium ion transport

description: Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


name: cellular component assembly involved in morphogenesis

description: The cellular component assembly that is part of the initial shaping of the component during its developmental progression.


steroid binding

description: Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.


vilazodone

A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.


name: glycolytic process through glucose-6-phosphate

description: The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP.


lurasidone

An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizophrenia.


mononuclear cell migration

description: The movement of a mononuclear cell within or between different tissues and organs of the body.


subclavian artery

description: One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta.


Wound Infection

description: Infection of a break in the skin or other tissue.


name: positive regulation of lymphocyte activation

description: Any process that activates or increases the frequency, rate or extent of lymphocyte activation.


photoreceptor inner segment

description: The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.


name: negative regulation of NF-kappaB transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.


name: negative regulation of microtubule polymerization or depolymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.


negative regulation of gliogenesis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.


name: regulation of ER to Golgi vesicle-mediated transport

description: Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.


cellular response to toxic substance

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.


triglyceride catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.


name: regulation of vascular endothelial growth factor receptor signaling pathway

description: Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


regulation of mRNA stability

description: Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.


RNA 3'-end processing

description: Any process involved in forming the mature 3' end of an RNA molecule.


UMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate.


purine nucleotide biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.


vacuolar acidification

description: Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.


response to ether

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.


methoxamine

An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine .


calcium ion binding

description: Binding to a calcium ion (Ca2+).


regulation of pH

description: Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.


mitotic sister chromatid cohesion

description: The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.


name: regulation of receptor signaling pathway via JAK-STAT

description: Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.


name: glutathione derivative metabolic process

description: The chemical reactions and pathways involving glutathione derivative.


mRNA splice site recognition

description: Selection of a splice site by components of the assembling spliceosome.


neurotransmitter uptake

description: The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.


ribonuclease A activity

description: Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.


name: voltage-gated monoatomic ion channel activity

description: Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


nerve growth factor binding

description: Binding to nerve growth factor (NGF).


regulation of calcium ion import

description: Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


regulation of sprouting angiogenesis

description: Any process that modulates the frequency, rate or extent of sprouting angiogenesis.


peptide hormone processing

description: The generation of a mature peptide hormone by posttranslational processing of a prohormone.


exopeptidase activity

description: Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.


Albuminuria

description: Increased concentration of albumin in the urine.


idoxuridine

A pyrimidine 2'-deoxyribonucleoside compound having 5-iodouracil as the nucleobase; used as an antiviral agent.


Joint swelling

description: The presence of swelling in a joint.


regulation of translational initiation

description: Any process that modulates the frequency, rate or extent of translational initiation.


lung disorder

description: A disease involving the lung.


name: regulation of mitochondrial membrane permeability

description: Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.


name: negative regulation of Ras protein signal transduction

description: Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.


adrenal medulla

description: The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine.


name: negative regulation of cell cycle G1/S phase transition

description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.


Derlin-1 retrotranslocation complex

description: A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.


regulation of T cell apoptotic process

description: Any process that modulates the occurrence or rate of T cell death by apoptotic process.


name: negative regulation of transporter activity

description: Any process that stops or reduces the activity of a transporter.


smoothened signaling pathway

description: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.


XY body

description: A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.


proguanil

A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.


chlorpropamide

An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.


galactorrhea

description: Excessive or inappropriate lactation in females or males, and not necessarily related to pregnancy. Galactorrhea can occur either unilaterally or bilaterally, and be profuse or sparse. Its most common cause is hyperprolactinemia.


pyelonephritis

description: An inflammatory process affecting the kidney. The cause is most often bacterial, but may also be fungal in nature. Signs and symptoms may include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion.


name: cellular response to molecule of bacterial origin

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.


name: deoxyribonucleoside diphosphate metabolic process

description: The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.


diltiazem

A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.