name: Pathologic Stage I Retinoblastoma AJCC v8

description: Stage I includes: pT1, pT2, pT3, pN0, cM0, Any H. pT1: Intraocular tumor(s) without any local invasion, focal choroidal invasion, or pre-or intralaminar involvement of the optic nerve head. pT2: Intraocular tumor(s) with local invasion. pT3: Intraocular tumor(s) with significant local invasion. pN0: No lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


name: Lacrimal Drainage System Non-Keratinizing Squamous Cell Carcinoma

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A squamous cell carcinoma of the lacrimal drainage system characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization.


Actinic Damage

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing


Refractory Urinary System Carcinoma

description: Urinary system carcinoma that does not respond to treatment.


name: Recurrent Malignant Male Reproductive System Neoplasm

description: The reemergence of a malignant male reproductive system neoplasm after a period of remission.


name: Invasive Bladder Urothelial Carcinoma with Squamous Differentiation

description: An invasive urothelial carcinoma of the bladder that exhibits squamous differentiation.


name: Mixed Phenotype Acute Leukemia, T/Megakaryocytic

description: A very rare mixed phenotype acute leukemia in which the blasts show evidence of T-cell and megakaryocytic lineage but are negative for KMT2A rearrangement and t(9;22)(q34;q11.2) translocation.


Conjunctival Melanoma In Situ

description: A term that refers to conjunctival melanocytic intraepithelial lesions with severe atypia involving close to full thickness of the epithelium or lesions with histologic characteristics of melanoma that lack documented evidence of subepithelial invasion.


Thyroid colloid nodule

description: A non-cancerous thyroid gland nodule that contains colloid material.


Clinical Stage I Retinoblastoma AJCC v8

description: Stage I includes: cT1, cT2, cT3, cN0, cM0, Any H. cT1: Intraretinal tumor(s) with subretinal fluid 5 mm or less from the base of any tumor. cT2: Intraocular tumor(s) with retinal detachment, vitreous seeding, or subretinal seeding. cT3: Advanced intraocular tumor(s). cN0: No regional lymph node involvement. cM0: No signs or symptoms of intracranial or distant metastasis. HX: Unknown or insufficient evidence of a constitutional RB1 gene mutation. H0: Normal RB1 alleles in blood tested with demonstrated high-sensitivity assays. H1: Bilateral retinoblastoma, retinoblastoma with an intracranial primitive neuroectodermal tumor (i.e., trilateral retinoblastoma), patient with family history of retinoblastoma, or molecular definition of a constitutional RB1 gene mutation. (AJCC 8th ed.)


Papillary serous cystadenoma

description: A serous benign or low malignant potential cystic epithelial neoplasm characterized by the presence of glandular epithelial cells forming papillary structures.


name: Steroid Resistant Acute Graft Versus Host Disease

description: Acute graft versus host disease that is resistant to treatment with steroids.


name: Fallopian Tube Metaplastic Papillary Tumor

description: A rare metaplastic lesion that arises from the fallopian tube. It is characterized by the presence of an intraluminal papillary proliferation composed of atypical epithelial cells with abundant eosinophilic cytoplasm. In the vast majority of cases, it is an incidental finding during microscopic examination of a fallopian tube in the postpartum period.


Recurrent Fallopian Tube Carcinoma

description: The reemergence of fallopian tube carcinoma after a period of remission.


Premalignant Neoplasm

description: A neoplasm that is composed of dysplastic cells and there is no morphologic evidence of infiltration of the surrounding tissues.


name: Non-Neoplastic Disorder by Special Category


ROSE Cluster 1

description: Gene expression cluster 1 as determined by Recognition of Outliers by Sampling Ends (ROSE) in high-risk B-precursor acute lymphoblastic leukemia.


Recurrent Nervous System Neoplasm

description: The reemergence of a nervous system neoplasm after a period of remission.


Astler-Coller C1 Colon Carcinoma

description: Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.)


name: Refractory T-Cell Large Granular Lymphocyte Leukemia

description: T-cell large granular lymphocyte leukemia that is resistant to treatment.


Hereditary Malignant Neoplasm

description: Malignant neoplasms occurring in families at a rate greater than that expected by chance and caused by germline mutations in a specific gene.


Occlusion of inferior vena cava

description: Blockage of the lumen of the inferior vena cava.


name: Lugano Classification Advanced Stage Adult Lymphoma AJCC v8

description: Advanced stage adult lymphoma based on the Lugano classification criteria. It includes stages III and IV. (from AJCC 8th Ed.)


Monogenic Hyperinsulinism

description: A genetically heterogenous group of hyperinsulinemic conditions caused by mutation(s) in one of the many genes involved in the regulation of insulin secretion.


Cervix carcinoma recurrent

description: The reemergence of cervical carcinoma after a period of remission.


Cancer of Urinary Tract

description: A primary or metastatic malignant neoplasm involving the urinary tract.


Ectopic ureter

description: A congenital anomaly in which the ureteral orifice drains into an abnormal location.


Advanced Rare Malignant Solid Neoplasm

description: A rare malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Endometrial Endometrioid Adenocarcinoma with Clear Cell Change

description: A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.


name: Extended Oligoarticular Juvenile Idiopathic Arthritis

description: Oligoarticular juvenile idiopathic arthritis that eventually involves more than four separate joints.


name: Staphylococcal arthritis and polyarthritis


name: Intellectual Disability, Autosomal Dominant 4

description: An autosomal dominant condition caused by mutation(s) in the CHAMP1 gene, encoding chromosome alignment-maintaining phosphoprotein 1. It is characterized by moderate to severe intellectual disability with poor speech acquisition. Variable dysmorphic features may be present as well.


Neoplasm of lacrimal drainage system

description: A benign or malignant neoplasm that affects the lacrimal drainage system.


Ovarian Infection

description: An infectious process affecting the ovary.


name: Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


name: Invasive Urothelial Carcinoma with Trophoblastic Differentiation

description: An invasive urothelial carcinoma characterized by the presence of trophoblastic differentiation.


Occupational Malignant Neoplasm

description: Malignant neoplasm secondary to occupational exposure to carcinogens.


Neuroendocrine cervical carcinoma

description: A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma.


Acute Stroke Related to COVID-19

description: The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system in a patient with probable or confirmed acute COVID-19.


name: Verrucous carcinoma of the oral cavity stage IV


Supratentorial Meningioma

description: A meningioma that affects the supratentorial brain.


Glassy cell carcinoma

description: A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm.


name: Stage IIC Fallopian Tube Cancer AJCC v6 and v7

description: Stage IIC includes: T2c, N0, M0.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th and 7th eds.)


Low grade appendiceal mucinous neoplasm

description: A well differentiated mucinous neoplasm that arises from the appendix.  It is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei.


Distress

description: A state of physiological or psychological stress that cannot be compensated for by normal adaptive measures.


Genitourinary System Neoplasm

description: A benign or malignant neoplasm that affects the genitourinary system.


Urethral Cancer by AJCC v8 Stage

description: A term that refers to the staging of urethral cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs).  (from AJCC 8th Ed.)


Diffuse Non-Pontine Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system, other than the pons.


name: Cerebral Venous Thrombosis Related to COVID-19


Perihepatic abscess

description: An abscess that is located in the anatomical space surrounding the liver, but which is outside of the liver capsule itself.


Panniculitis Ossificans

description: A condition characterized by subcutaneous fat necrosis with heterotopic calcification. It often occurs as a result of injury to the area.


name: Recurrent Fallopian Tube Clear Cell Adenocarcinoma

description: The reemergence of fallopian tube clear cell adenocarcinoma after a period of remission.


Astler-Coller B3 Rectal Carcinoma

description: Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.)


name: Vaginal Mucinous Adenocarcinoma, Intestinal-Type

description: A vaginal mucinous adenocarcinoma that resembles a large intestinal adenocarcinoma.


Meningeal Leukemia

description: Infiltration of the meninges by an acute or chronic leukemia.


Locally Advanced Malignant Mesothelioma

description: Malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.


Acquired hydrocephalus

description: Hydrocephalus that results from head trauma, brain tumors, intracranial hemorrhage, or meningitis.


name: Recurrent Childhood Undifferentiated High Grade Pleomorphic Sarcoma of Bone

description: The reemergence of undifferentiated high grade pleomorphic sarcoma of bone in childhood after a period of remission.


name: Refractory Adult Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that occurs in adulthood and does not respond to treatment.


Pigmented Actinic Keratosis

description: Actinic keratosis characterized by the presence of increased melanin pigmentation in the basal keratinocytes.


name: Metastatic Childhood Retinoblastoma by Toronto Guidelines v2

description: Distant metastases present. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Stage II Extragonadal Non-Seminomatous Germ Cell Tumor


Myxoid pleomorphic liposarcoma

description: An exceptionally rare, aggressive adipocytic neoplasm, typically occurring in children and adolescents. Myxoid pleomorphic liposarcoma shows mixed histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and lacks the gene fusions and amplifications of myxoid liposarcoma, atypical lipomatous tumor, and dedifferentiated liposarcoma. (WHO 2020)


name: T Acute Lymphoblastic Leukemia with SPI1 Rearrangement

description: T acute lymphoblastic leukemia characterized by the presence of SPI1 gene rearrangement. It has a poor prognosis.


name: Pediatric Non-Congenital Ventricular Tachycardia

description: A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin that was not present at birth in an individual under age 21. The QRS complexes are wide and have an abnormal morphology.


Esophageal carcinoma recurrent

description: An esophageal carcinoma which has reappeared after a period of remission or after presumed treatment.


Stage II Fallopian Tube Cancer

description: Stage II includes: (T2, N0, M0); IIA: (T2a, N0, M0); IIB (T2b, N0, M0); IIC (T2c, N0, M0).  T2: Tumor involves one or both fallopian tubes with pelvic extension.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  T2b: Extension to other pelvic structures.  T2c: Pelvic extension with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th and 7th eds.)


Hyperviscosity

description: An increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity.


Stage IB Cervical Cancer AJCC v6 and v7

description: Stage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)


Perceptual Distortion

description: An incorrect understanding or interpretation of sensory input.


Metastatic High Grade Sarcoma

description: High-grade sarcoma that has spread from its original site of growth to another anatomic site.


name: benign granular cell tumor of gallbladder

description: A granular cell tumor that arises from the gallbladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


Aplastic Anemia due to Hepatitis

description: Bone marrow failure defined as pancytopenia, secondary to hepatitis.


Reticulosarcoma of spleen

description: An antiquated term that refers to a non-Hodgkin lymphoma composed of diffuse infiltrates of large, often anaplastic lymphocytes affecting the spleen.


name: immune effector cell-associated neurotoxicity syndrome, grade 4

description: Immune effector cell-associated neurotoxicity syndrome (ICANS) characterized by an immune-effector cell-associated encephalopathy (ICE) tool score of 0 or if the ICE scale cannot be performed (for adults and children over 12), or if the Cornell Assessment of Pediatric Delirium (CAPD) scale cannot be performed (for children 12 and under), the inability of the affected individual to be arousable without vigorous or repetitive tactile stimuli, life-threatening prolonged (greater than 5 minutes) seizures, or repetitive clinical or electroencephalographically-detected seizures without ever returning to baseline, deep focal motor weakness, diffuse cerebral edema evident on neuroimaging, decerebrate or decorticate posturing, cranial nerve VI palsy, papilledema or Cushing's triad (bradycardia, hypertension, respiratory depression).


Cervical Neuroendocrine Tumor G2

description: A well-differentiated, intermediate grade neuroendocrine neoplasm arising from the cervix.


name: Ancylostomiasis due to Ancylostoma braziliense (disorder)

description: Infection by Ancylostoma braziliense.


Metastatic Cervical Adenocarcinoma

description: A cervical adenocarcinoma that has spread to another anatomic site.


Refractory Cutaneous Melanoma

description: Melanoma of the skin that is resistant to treatment.


Breast Schwannoma

description: A schwannoma that arises from the breast.


Decreased Concomitant Drug Half Life

description: Decreased period of time required for the concentration or amount of a concomitant drug in the body to be reduced to exactly one-half of a given concentration or amount.


Gastrointestinal disorder congenital

description: An abnormality of the digestive system that is present at birth or detected in the neonatal period.


Structural Heart Abnormality

description: An anatomic deformity of the heart, ventricles or great vessels.


Retinal arteriovenous malformation

description: A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures in the retina.


Foreign body granuloma of muscle

description: An inflammatory lesion in the muscle comprised of epithelioid histiocytes and chronic inflammation that is caused by the presence of extraneous material .


name: Refractory Cervical Squamous Cell Carcinoma

description: Cervical squamous cell carcinoma that is resistant to treatment.


Recurrent EBV-Related Lymphoma

description: The reemergence of EBV-related lymphoma after a period of remission.


Paratesticular Adenomatoid Tumor

description: An adenomatoid tumor arising from the paratesticular structures. It is the most common tumor of the paratesticular region. The tail of the epididymis is the most common site of involvement.


Pancreatic adenocarcinoma metastatic

description: An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites.


description: A lymphoproliferative disorder that develops in an individual with HIV infection.


name: Glioneuronal Tumor with Neuropil-Like Islands

description: A rare, WHO grade II or III infiltrating astrocytoma characterized by the presence of sharply demarcated foci, composed of a neuropil-like matrix.


Stage IIIC Esophageal Cancer AJCC v7

description: Stage IIIC includes: For squamous cell carcinoma: (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus. For adenocarcinoma: (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 7th ed.)


name: Extrahepatic Bile Duct Neuroendocrine Tumor

description: A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts.


Diabetic foetopathy

description: A constellation of features seen in the hyperinsulinemic fetus of a diabetic mother that include macrosomia, postnatal hypoglycemia and polycythemia.


name: Type III Total Anomalous Pulmonary Venous Return

description: Total anomalous pulmonary venous return in which the common pulmonary vein connects to the portal venous system through the diaphragm.


name: Malignant Outer Hair Sheath and Infundibulum Neoplasm

description: A malignant neoplasm that arises from the outer hair sheath and infundibulum.


Stage IIA Bone Sarcoma AJCC v7

description: Stage IIA includes: T1, N0, M0, G3, G4.  T1: Tumor 8 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Myopathy Secondary to Glycogen Storage Disorder

description: A myopathy that was caused by a primary disorder of glycogen storage.


Lacrimal Gland Oncocytic Adenocarcinoma

description: An adenocarcinoma that arises from the lacrimal gland. It is characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm.


name: Hodgkin's disease of intrapelvic lymph nodes

description: Stage I Hodgkin lymphoma involving the subdiaphragmatic region.


name: T Acute Lymphoblastic Leukemia, HOXA Dysregulated

description: T acute lymphoblastic leukemia characterized by an ectopic activation of the HOXA genes.


Vulvar Yolk Sac Tumor

description: A rare yolk sac tumor that arises from the vulva.


Bone marrow mastocytosis

description: A variant of indolent systemic mastocytosis that affects predominantly older males. It is characterized by a limited degree of bone marrow infiltration by clonal mast cells and an absence of skin involvement. The serum tryptase levels are normal or slightly elevated.


Radiation retinopathy

description: Injury of the retina following exposure to radiation.  The retinal injury results from occlusive microangiopathy caused by endothelial cell loss.


Stage 0 Vulvar Cancer

description: Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma). N0: No regional lymph node metastasis.  M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)


name: Chest Pain in Right Fourth Intercostal Space

description: The location of the chest pain is within the fourth intercostal space on the right side.


Fibroblastic reticular cell neoplasm

description: A very rare dendritic cell sarcoma affecting the lymph nodes, spleen, and soft tissues. Morphologically it is similar to the interdigitating dendritic cell sarcoma or follicular dendritic cell sarcoma. The tumor cells are positive for cytokeratin and CD68.


Bacterial Toxemia

description: The condition resulting from the spread of bacterial products (toxins) by the bloodstream.


Slipped extraocular muscle

description: Weakness of extraocular muscle function as a result of inadequate securing of the muscle to the sclera during strabismus surgery.


Excessive weight gain in pregnancy

description: In a woman with a normal weight pre-pregnancy body mass index (BMI), i.e. 18.5-24.9, the weight gained during pregnancy exceeds a total weight gain of 35 lbs. In a woman with an underweight pre-pregnancy body mass index (BMI), i.e. less than 18.5, the weight gained during pregnancy exceeds a total weight gain of 40 lbs. In a woman with an overweight pre-pregnancy body mass index (BMI), i.e. 25.0-29.9, the weight gained during pregnancy exceeds a total weight gain of 25 lbs. In a woman with an obese pre-pregnancy body mass index (BMI), i.e. greater than 30, the weight gained during pregnancy exceeds a total weight gain of 20 lbs. These standards are supported for the whole population irrespective of height, race or ethnicity.


name: Stage IIIA1 Fallopian Tube Cancer AJCC v8

description: Stage IIIA1 includes: T1/2, N1, M0. T1: T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis. (AJCC 8th Ed.)


Adult Acute Myelomonocytic Leukemia

description: An acute myelomonocytic leukemia occurring in adults.


Viremia

description: A laboratory test result indicating the presence of a virus in the blood.


Locally Recurrent Merkel Cell Carcinoma

description: The reemergence of Merkel cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.


Refractory WHO Grade 4 Glioma

description: A WHO grade 4 glioma that is resistant to treatment.


name: Clinical Stage IIA Cutaneous Melanoma AJCC v8

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Childhood Digestive System Neuroendocrine Tumor

description: A neuroendocrine tumor that arises from the digestive system and occurs during childhood.


name: Deletion of Chromosome 3p Associated Meningioma

description: A meningioma that is associated with deletion of chromosomal arm 3p.


name: Metastatic Peritoneal Malignant Mesothelioma

description: Peritoneal malignant mesothelioma that has spread from its original site of growth to another anatomic site.


name: Prostate Acinar Pseudohyperplastic Adenocarcinoma

description: Acinar prostate adenocarcinoma characterized by the presence of neoplastic large glands that resemble the benign, non-neoplastic prostate glands.


Spermatogenic granuloma

description: A lump of extravasated sperm in the paratesticular region in men who have undergone vasectomy.


Other Finding

description: An additional finding not previously noted.


Microbiology Laboratory Test Result

description: Clinical laboratory test findings associated with detection, identification or quantitation of microorganisms or products derived from them.


description: Malignant neoplasm occurring in immunodeficient patients.


Hydroxyproline Urine Increased

description: A laboratory test result indicating abnormally high concentration of hydroxyproline in the urine.


Renal granular cell carcinoma

description: A renal cell carcinoma with eosinophilic cytoplasm and high nuclear grade.  Granular cells can be seen in any subtype of renal cell carcinoma, including conventional clear cell carcinoma.  This term does not represent a specific subtype of renal cell carcinoma and should no longer be used.


name: Malignant Peripheral Nerve Sheath Tumor of the Skin

description: A malignant peripheral nerve sheath tumor that arises from the skin.


Coronary Venous Dissection

description: A tear within the wall of a coronary vein. (ACC)


name: Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin


Stage IVA Vulvar Cancer AJCC v8

description: Stage IVA includes: (T1-T2, N3, M0); (T3, Any N, M0). T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


name: Chondromesenchymal hamartoma of chest wall

description: A rare benign lesion that arises from the rib cage and affects infants.  It results in the formation of a mass which is composed of spindle cells, cartilage, and hemorrhagic cysts.  Surgical resection is usually curative.


name: Acute Myeloid Leukemia with Recurrent Genetic Abnormalities

description: A group of acute myeloid leukemias characterized by recurrent genetic abnormalities, mainly balanced translocations.  (WHO, 2001)


Immunoglobulin deposition disease

description: A mature B-cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease.


name: Disorder of eye due to diabetes mellitus

description: A group of disorders affecting the eye in patients with diabetes mellitus. It includes cataract, glaucoma, retinopathy, and blindness.


Testicular Cancer by AJCC v8 Stage

description: A term that refers to the staging of testicular cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to postpubertal germ cell tumors of the testis and malignant sex cord-stromal tumors of the testis. It does not apply to spermatocytic tumors (no AJCC staging system), nonmalignant sex cord-/gonadal -stromal tumors (no AJCC staging system), prepubertal germ cell tumors (no AJCC staging system), hematolymphoid tumors (hematologic malignancies staging system), and paratesticular neoplasms (no AJCC staging system).  (from AJCC 8th Ed.)


Refractory Appendix Adenocarcinoma

description: Appendix adenocarcinoma that is resistant to treatment.


Decreased NCF2 Expression

description: An indication that the expression of NCF2 is lower than the normal range of values.


Second Primary Cancers

description: A primary malignant neoplasm in a patient who has been already diagnosed with a primary malignant neoplasm in another anatomic site.


name: Solar Radiation-Related Cutaneous Melanoma

description: Cutaneous melanoma that arises following exposure to solar radiation.


Stage II Vulva Cancer AJCC v6

description: Stage II includes: T2, N0, M0.  T2: Tumor confined to the vulva or vulva and perineum, more than 2cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)


Thrombocytopenia 5

description: An autosomal dominant disorder characterized by decreased platelets, bleeding tendency, and mutation in the ETV6 gene. It is associated with an increased risk of developing hematologic malignancy.


Silicon granuloma

description: A granuloma that forms in response to silicone exposure.


Stage IVA Cervical Cancer AJCC v8

description: Stage IVA includes: T4, Any N, M0. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (from AJCC 8th Ed.)


name: Prolonged depressive adjustment reaction

description: Temporary but prolonged and maladaptive depressive signs and symptoms associated with a life event.


Recurrent Paraganglioma

description: The reemergence of paraganglioma after a period of remission.


Microabscess

description: A very small, tiny abscess.


name: Moderately Differentiated Prostate Adenocarcinoma

description: An invasive prostate adenocarcinoma characterized by the presence of malignant cells exhibiting moderate differentiation.


Acute pulmonary embolism

description: An acute embolism to the pulmonary vasculature.


Very Severe Aplastic Anemia

description: Aplastic anemia that is characterized by bone marrow (BM) cellularity less than 25% (or less than 50% if BM is comprised of less than 30% hematopoietic cells), and two or more of the following: absolute neutrophil count of less than 200 per microliter; platelet count of less than 20,000 per microliter; or an absolute reticulocyte count of less than 20,000 per microliter.


name: Angiotensin converting enzyme inhibitor foetopathy

description: Fetal embryopathy associated with maternal angiotensis converting enzyme (ACE) inhibitor use during pregnancy that may include fetal acute renal failure, growth restriction, oligohydramnios, calvaria abnormalities, preterm birth, and pulmonary hypoplasia with respiratory distress.


name: Decreased Concomitant Drug Peak Blood Concentration

description: Decreased maximum (peak) concentration of a concomitant drug observed after its administration.


Appendix Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the appendix.


Leukemia recurrent

description: The reemergence of leukemia after a period of remission.


Metastatic Non-Cutaneous Melanoma

description: A non-cutaneous melanoma that has spread from its original site of growth to another anatomic site.


Childhood Large Cell Lymphoma

description: A large cell lymphoma occurring in childhood.


Refractory Esophageal Carcinoma

description: Esophageal carcinoma that is resistant to treatment.


name: Non-Neoplastic, Non-Molar Gestational Trophoblastic Disorder

description: A category of non-neoplastic gestational trophoblastic disorders that includes the exaggerated placental site reaction and placental site nodule or plaque. It does not include hydatidiform mole.


Conjunctival Carcinoma

description: A carcinoma that arises from the conjunctiva.


Esophageal Neuroendocrine Carcinoma

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Placental aromatase deficiency

description: An autosomal recessive condition that results in aromatase deficiency in the placenta, causing temporary virilization of the pregnant woman and virilization of her 46,XX fetus.


name: Invasive Large Nested Urothelial Carcinoma

description: A rare invasive urothelial carcinoma characterized by the presence of medium to large nests of malignant cells.


Refractory Malignant Germ Cell Tumor

description: Malignant germ cell tumor resistant to treatment.


Refractory Neuroendocrine Neoplasm

description: A neuroendocrine neoplasm that does not respond to treatment.


Non-Neoplastic Breast Disorder

description: A non-neoplastic disorder that affects the breast. Representative examples include fibrocystic disease, gynecomastia, mastitis, and adenosis.


High Grade Intraepithelial Neoplasia

description: A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia).


name: Transient myocardial ischemia of newborn

description: A condition characterized by a temporary imbalance between the oxygen supply and demand of the heart muscle in the newborn.


Refractory Adenovirus Infection

description: An adenovirus infection that does not respond to treatment.


name: Unresectable Renal Pelvis and Ureter Urothelial Carcinoma

description: Renal pelvis and ureter urothelial carcinoma that is not amenable to surgical resection.


name: Adverse Drug Reaction to Systemic Antibiotic

description: A detrimental or unintended response associated with the use of a systemic antibiotic.


Refractory Acute Lymphoblastic Leukemia

description: Acute lymphoblastic leukemia that does not respond to treatment.


name: Human Papillomavirus-Independent Cervical Adenocarcinoma In Situ

description: Cervical adenocarcinoma in situ not associated with human papillomavirus infection.


name: Musculoskeletal Chest Pain due to Myositis

description: A condition in which there is musculoskeletal chest pain secondary to inflammation of the muscle tissue. (ACC/AHA)


name: Hematologic Neoplasm with Germline ANKRD26 Mutation

description: An autosomal dominant disorder characterized by moderate thrombocytopenia and increased risk of developing myelodysplastic syndrome/acute myeloid leukemia. This disorder is characterized by germline mutations in ANKRD26, located on chromosome band 10p12.1. (WHO 2017)


Early Unfavorable Hodgkin Lymphoma

description: An early Hodgkin lymphoma with unfavorable prognosis.


Stage IIB Appendix Carcinoma AJCC v7

description: Stage IIB includes: T4a, N0, M0. T4a: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 7th ed.)


name: Childhood TdT Positive Acute Lymphoblastic Leukemia

description: TdT positive acute lymphoblastic leukemia that occurs during childhood.


Fetus in fetu

description: An exceptionally rare congenital abnormality in which a malformed and parasitic fetus is located within the body of its twin.


name: Endometrioid adenocarcinoma, ciliated cell variant

description: An endometrioid adenocarcinoma arising from the endometrium, in which ciliated cells line the majority of the malignant glands.


Adult Acute Myeloblastic Leukemia

description: An acute myeloid leukemia occurring in adults.


Nonorganic Insomnia

description: Insomnia as a result of an extrinsic cause.


name: EBV-Related Lymphoproliferative Disease with Primary Immunodeficiency

description: An EBV-related lymphoid proliferation that arises in the setting of immune deficiency due to a primary immunodeficiency or immunoregulatory disorder.


name: Low Grade Anal Canal Intraepithelial Neoplasia

description: Intraepithelial neoplasia involving the anal canal.  The epithelial cells exhibit mild dysplasia (grade I intraepithelial neoplasia).


name: Gallbladder Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia

description: A non-invasive mucinous cystic neoplasm that arises from the gallbladder epithelium.  It is characterized by the presence of moderate atypia.


Osteosarcoma recurrent

description: The reemergence of osteosarcoma after a period of remission.


name: Acute Myeloid Leukemia with In-Frame bZIP CEBPA Mutation

description: An acute myeloid leukemia characterized by the presence of CEBPA bZIP domain mutation. It is associated with a favorable clinical outcome.


IgD Monoclonal Gammopathy

description: An abnormal laboratory test result indicating the presence of IgD monoclonal immunoglobulin in the blood or urine.


Chest wall cyst

description: A cystic lesion in the chest wall.


Borderline Resectable Mass

description: A tumor mass finding that refers to a continuum between resectable and locally advanced unresectable disease.


name: Stage II Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8

description: Stage II includes: T2, N0, M0. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 8th Ed.)


Antenatal Hydronephrosis

description: Hydronephrosis that occurs in a fetus.


name: Stage IV Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)


Malignant Proliferating Pilar Tumor

description: A rare malignant neoplasm that arises from the outer root sheath of the hair follicle. It usually occurs in the scalp, face and trunk. Histopathology shows cords of malignant squamous cells infiltrating into the dermis.


Stage IB Bone Cancer AJCC v7

description: Stage IB includes: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX).  T2: Tumor more than 8 cm in greatest dimension.  T3: Discontinuous tumors in the primary bone site.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G1: Well differentiated-low grade.  G2: Moderately differentiated-low grade.  GX: Grade cannot be assessed. (AJCC 7th ed.)


name: Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Depletion


name: Platinum-Resistant Malignant Germ Cell Tumor

description: A malignant germ cell tumor that is resistant to platinum therapy.


name: Adult Unfavorable Prognosis Hodgkin Lymphoma

description: A Hodgkin lymphoma with unfavorable prognosis that occurs during adulthood.


Mycotic pericarditis

description: Pericarditis that is caused by an infection with a fungal agent.


name: Metastatic malignant neoplasm to conjunctiva

description: A malignant neoplasm that has spread to the conjunctiva from another anatomic site.


name: Anaplastic (Malignant) Intracranial Meningioma

description: An anaplastic meningioma that arises within the cranial cavity.


name: Hereditary factor XII deficiency disease

description: A rare autosomal recessive inherited bleeding disorder caused by deficiency of coagulation factor XII. It may be asymptomatic or manifest with bleeding.


Metastatic Vaginal Carcinoma

description: A carcinoma that arises from the vagina and has metastasized to another anatomic site.


name: Osteoclastic Giant Cell-Rich Tumor of Bone

description: A benign, intermediate, or malignant bone tumor characterized by the presence of osteoclast-like giant cells. Clinical presentation includes pain, edema, and decreased range of motion in the affected joint.


Metastatic endometrioid carcinoma

description: An endometrioid adenocarcinoma that has spread from its original site of growth to another anatomic site.


name: Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Recurrent Malignant Neoplasm of Multiple Primary Sites

description: Reemergence of a malignant neoplasm of multiple primary sites after a period of remission.


Thalassemic Osteopathy

description: Bone disorders that present in thalassemia patients.


name: Breast Fibrocystic Change, Proliferative Type without Atypia

description: Breast fibrocystic change characterized by the presence of epithelial cell hyperplasia.  There is no evidence of epithelial atypia.


Cervical Neuroendocrine Tumor G1

description: A well-differentiated, low grade neuroendocrine neoplasm that arises from the cervix.


Low ADAMTS13 Activity

description: A finding indicating that a significantly lower than expected activity for the proteinase a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) is detected in a sample. This finding is associated with thrombotic thrombocytopenic purpura.


Granular Cell Astrocytoma

description: An astrocytoma characterized by the presence of large numbers of neoplastic cells with granular, PAS-positive cytoplasm. It is associated with an aggressive clinical course, even when the histologic features suggest a lower-grade astrocytoma.


name: High Grade Conjunctival Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with high-grade dysplastic features involving the conjunctival epithelium.


name: Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage II includes: IIA: T1, N1, M0; IIB: T2, N0, M0. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


name: Intraoperative Reproductive System Injury

description: Damage to the reproductive organs during a surgical procedure.


Nuclear Cataract Grade 2

description: A stage of nuclear sclerotic cataract marked by moderate yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Retinoblastoma, undifferentiated

description: A retinoblastoma composed of small, undifferentiated cells. It is often associated with necrotic changes.


Malignant tumor, small cell type

description: A malignant neoplasm characterized by the presence of small atypical cells.


Stage IIC Prostate Cancer AJCC v8

description: Stage IIC includes: (T1-2, N0, M0, PSA less than 20, Grade Group 3); (T1-2, N0, M0, PSA less than 20, Grade Group 4). T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: T Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

description: T-lymphoblastic leukemia/lymphoma in which further genetic/molecular characterization is not available.


Bladder Paraganglioma

description: An extra-adrenal sympathetic paraganglioma arising from the urinary bladder.  Clinical signs include hypertension and hematuria.


name: Childhood Malignant Genitourinary System Neoplasm

description: A malignant neoplasm that affects the genitourinary system during childhood.


Broad Ligament Serous Adenocarcinoma

description: A rare serous adenocarcinoma that arises from the broad ligament.


name: Malignant Non-Hodgkin Lymphoma, Cleaved Cell


name: Vaginal Keratinizing Squamous Cell Carcinoma

description: A squamous cell carcinoma that arises from the vagina and is characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present.


Cutaneous neurofibroma

description: A neurofibroma that grows along small branches of nerves in the dermis in patients with neurofibromatosis. It presents as a solid cutaneous tumor.


Esophageal adenocarcinoma recurrent

description: An esophageal adenocarcinoma which has reappeared after a period of remission or after presumed treatment.


Cervical Cancer by AJCC v7 Stage

description: A term that refers to the staging of cervical cancer according to the American Joint Committee on Cancer, 7th edition.


Acute Myocardial Injury

description: Acute myocardial injury diagnosed by rise and fall in cardiac troponin above the 99th percentile of a reference population.


Stage IIA1 Cervical Cancer AJCC v9

description: Stage IIA1 includes: T2a1, N0, M0. T2a1: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Conjunctival Spitz Nevus

description: A rare nevus that arises from the conjunctiva. It is characterized by the presence of large spindle-shaped or epithelioid melanocytes.


Prostate Undifferentiated Carcinoma

description: An invasive prostate carcinoma characterized by the presence of undifferentiated malignant cells.


Actinomycotic granuloma

description: A granuloma that develops in response to Actinomycotic fungal infection.


Refractory Liposarcoma

description: Liposarcoma that does not respond to treatment.


Stage IV Cervical Cancer AJCC v6 and v7

description: Stage IV includes: IVA: (T4, Any N, M0); IVB (Any T, Any N, MI). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M1: Distant metastasis. (AJCC 6th and 7th eds.)


Anaplastic Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered, characterized by the presence of high mitotic activity, cytologic atypia, and architectural distortion.


Refractory Appendix Carcinoma

description: Appendix carcinoma that is resistant to treatment.


Critical illness myopathy

description: Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation.


name: Lugano Classification Limited Stage Adult Lymphoma AJCC v8

description: Limited stage adult lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE. (from AJCC 8th Ed.)


name: Childhood Acute Lymphoblastic Leukemia CNS 2 Toronto Guidelines v2

description: No clinical signs of CNS involvement and blasts in CSF and either: WBC < 5/μL CSF or WBC > or = 5/uL CSF and RBC > or = 10/uL CSF and WBC/RBC in CSF < or = 2x WBC/RBC in blood. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Perforation due to Lead

description: Penetration of a lead through a systemic vein, coronary vein, or the myocardium. (ACC)


Stage IIIC Appendix Carcinoma AJCC v8

description: Stage IIIC includes: Any T, N2, M0. N2: Four or more regional lymph nodes are positive. M0: No distant metastasis. (AJCC 8th ed.)


description: Trigeminal neuralgia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


Metastatic Merkel Cell Carcinoma

description: A Merkel cell carcinoma that has spread from the original site of growth to another anatomic site.


Endometrial Neuroendocrine Carcinoma

description: A small cell or large cell neuroendocrine carcinoma arising from the endometrium.


name: Ampullary Flat Intraepithelial Neoplasia, High Grade

description: A non-polypoid, preinvasive neoplasm that arises from the ampulla of Vater.  It is characterized by the presence of high grade dysplasia.


name: Chronic Ocular Graft Versus Host Disease

description: Chronic graft versus host disease occurring in the eye.


Injury Asphyxation

description: Acute compression of the thoracic cavity, causing  increased intrathoracic pressure and the backflow of blood from the right atrium and superior vena cava into the brachiocephalic and jugular veins, with resulting stagnation of blood flow and subsequent localized blood-oxygen desaturation in the head and neck.


Esophageal Basal Cell Hyperplasia

description: A reactive (non-neoplastic) hyperplastic process affecting the esophageal squamous epithelium that is caused by inflammation.  Morphologically it involves more than 15% of the thickness of the esophageal squamous epithelium.  Its association with an increase risk of developing squamous cell carcinoma remains controversial.


name: Pathologic Stage IIIA Cutaneous Melanoma AJCC v8

description: Stage IIIA includes: T1a/b-T2a, N1a or N2a, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No.  M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0); IVB: (Any T, Any N, M1). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


Diffuse Midline Glioma

description: A diffuse glioma that arises from the midline structures of the central nervous system. The majority of these tumors are found in the brainstem.


name: Unresectable Gastroesophageal Junction Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that arises from the gastroesophageal junction and is not amenable to surgical resection.


name: Adult Acute Myeloid Leukemia without Maturation

description: An acute myeloid leukemia without maturation occurring in adults.


name: Gravid Uterus Adjusted Maternal Body Weight Gain

description: The amount of maternal body weight gained over a period of time where the weight at the end of the interval is adjusted for the gravid uterus weight. This is derived by subtracting the maternal body weight adjusted for the gravid uterus from the total maternal body weight.


Advanced Angiosarcoma

description: An angiosarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Unresectable Basal Cell Carcinoma

description: Basal cell carcinoma that is not amenable to surgical resection.


anaplastic carcinoma of urethra

description: An undifferentiated carcinoma arising from the urethra.


Conjunctival Blue Nevus

description: A benign melanocytic neoplasm that arises from the conjunctiva. It is characterized by the presence of dendritic and spindle-shaped melanocytes in the subepithelial connective tissue. It presents as a dark brown or black, slightly elevated conjunctival lesion.


Intraoperative Endocrine Injury

description: Damage to an endocrine gland during a surgical procedure.


Bilateral anophthalmos of eyes

description: A rare congenital abnormality characterized by the complete absence of ocular tissue in both orbits.


name: acute megakaryoblastic leukemia in relapse

description: The reemergence of acute megakaryoblastic leukemia after a period of remission.


name: Childhood Retinoblastoma by Toronto Guidelines v2 Stage

description: A term that refers to the staging of childhood retinoblastoma according to the Toronto childhood cancer staging guidelines v2.


Localized Lymphoma

description: A lymphoma that is confined to a specific site without evidence of spread to other anatomic sites.


malignant enteroglucagonoma

description: A glucagon-producing malignant endocrine neoplasm. It displays vascular invasion and metastasizes to other anatomic sites.


name: Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma

description: Extrapulmonary large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Stage III Renal Pelvis and Ureter Cancer AJCC v7

description: Stage III includes: T3, N0, M0. T3: For renal pelvis only: tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  For ureter only: tumor invades beyond muscularis into periureteric fat.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 7th ed.)


Anal cancer recurrent

description: The reemergence of anal carcinoma after a period of remission.


Gender identity disorder

description: A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).


Thoracic Meningocele

description: A congenital abnormality in the thoracic region of the spine in which the meninges protrude through a defect in the spinal column.


name: Unresectable Glioneuronal and Neuronal Tumors

description: Glioneuronal and neuronal tumors that are not amenable to surgical resection.


name: Refractory Endometrial Clear Cell Adenocarcinoma

description: Endometrial clear cell adenocarcinoma that is resistant to treatment.


name: Locally Advanced Extrapulmonary Neuroendocrine Carcinoma

description: Extrapulmonary neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Reflux

description: An abnormal backward flow of a body fluid.


Infant T Acute Lymphoblastic Leukemia

description: A T-acute lymphoblastic leukemia that occurs in infancy.


Metastatic Urethral Carcinoma

description: A urethral carcinoma that has spread to another anatomical site.


name: FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

description: Endometrial endometrioid adenocarcinoma exhibiting 6-50% solid non-glandular, non-squamous growth.


name: Beta-2-Microglobulin Greater than 3 g/mL

description: A laboratory test result indicating that beta-2-microglobulin is present in a sample at concentrations exceeding 3 g/mL.


name: Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

description: Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene).


Refractory Mucosal Melanoma

description: Mucosal melanoma that is resistant to treatment.


Glucokinase-Associated Hyperinsulinism

description: Hyperinsulinism due to activating mutation(s) in the gene GCK, encoding glucokinase.


Childhood Grade I Meningioma

description: A grade I meningioma that occurs during childhood.


name: Stage 0 Childhood Retinoblastoma by Toronto Guidelines v2

description: The tumor is confined to the globe. Enucleation has not been performed. (The patient is treated "conservatively" with either focal therapies or chemotherapy.) (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


Childhood Astroblastoma, MN1-Altered

description: An astroblastoma, MN1-altered that occurs during childhood.


Stage IIIA Prostate Cancer AJCC v8

description: Stage IIIA includes: T1-2, N0, M0, PSA 20 or more, Grade Group 1-4; T1: Prostate cancer with clinically inapparent tumor that is not palpable. T2: Prostate cancer in which the tumor is palpable and confined within the prostate. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4. (AJCC 8th ed.)


name: Invasive Bladder Conventional Urothelial Carcinoma

description: Invasive bladder urothelial carcinoma characterized by the presence of malignant cells forming trabeculae, cords, sheets, and nests. Individual malignant cells are also present.


FNCLCC Sarcoma Grade 1

description: A sarcoma with a total score of 2 or 3 according to the FNCLCC guidelines.


Refluxing Megaureter

description: A megaureter that demonstrates retrograde urine flow without ureteral obstruction.


Meningothelial Hamartoma

description: A hamartoma characterized by the presence of collections of non-neoplastic arachnoidal cells.


name: Malignant urinary tract neoplasm metastatic

description: The spread of a malignant neoplasm to the urinary tract from an adjacent or distant anatomic site.


transvestism

description: A disorder characterized by recurrent sexual urges, fantasies, or behaviors in a heterosexual male involving cross-dressing.


name: adenocarcinoma of gallbladder with squamous metaplasia

description: An infiltrating adenocarcinoma of the gallbladder characterized by the presence of metaplastic changes of the malignant glandular cells to squamous cells.


Hodgkin Lymphoma by Ann Arbor Stage

description: An anatomic stage for Hodgkin lymphomas based on the Ann Arbor classification criteria.


Complicated malaria

description: Acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected).


name: Papillary transitional cell carcinoma, non-invasive

description: A transitional cell carcinoma characterized by a papillary growth pattern and lack of stromal invasion.


name: Non-Keratinizing Primary Intraosseous Squamous Cell Carcinoma -Solid Type

description: A squamous cell carcinoma that arises centrally from the jaw.  It is characterized by a solid pattern, lack of prominent keratinization, infiltration of the marrow spaces, and osseous resorption.


name: High Grade Prostatic Intraepithelial Neoplasia, Inverted Variant

description: High grade prostatic intraepithelial neoplasia characterized by the presence of secretory cells with their nuclei polarized towards the lumen of the glands.


Non-Neoplastic Conjunctival Disorder

description: A non-neoplastic disorder that affects the conjunctiva.


Unresectable Bladder Carcinoma

description: Bladder carcinoma that is not amenable to surgical resection.


name: Stage I Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)


Stage IV Prostate Cancer AJCC v7

description: Stage IV includes: (T4, N0, M0, Any PSA, Any Gleason); (Any T, N1, M0, Any PSA, Any Gleason); (Any T, Any N, M1, Any PSA, Any Gleason). cT4: Tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall.  pT4: Invasion of rectum, levator muscles, and/or pelvic wall.  N1: Metastasis in regional lymph node(s).  M1: Distant metastasis.  (AJCC 7th ed.)


name: Diffuse Low Grade Glioma, BRAF p.V600E-Mutant

description: Diffuse low-grade glioma characterized by the presence of BRAF gene mutations encoding a p.V600E substitution mutation.


name: Pathologic Stage IIIB Cutaneous Melanoma AJCC v8

description: Stage IIIB includes: (T0, N1b, N1c, M0); (T1a/b-T2a, N1b/c or N2b, M0); (T2b/T3a, N1a-N2b, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration.  T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Recurrent Brain Neoplasm

description: The reemergence of a brain neoplasm after a period of remission.


description: A myelodysplastic/myeloproliferative neoplasm that is resistant to treatment.


name: Postoperative Spindle Cell Nodule of the Vagina

description: A rare, benign, non-neoplastic reactive lesion that develops in the vagina at the site of a prior operative procedure. It is composed of spindle cells, small blood vessels, and chronic inflammation.


Chemical Exposure

description: Contact with a chemical substance through touch, inhalation, or ingestion.


Radiation-Induced Cancer

description: A malignant neoplasm arising in a site exposed to radiation therapy.


Vulvar Blue Nevus

description: A benign nevus that arises from the vulva and is characterized by the presence of heavily pigmented dendritic melanocytes exclusively in the dermis.


Weight Change

description: An increase or decrease in the weight of an individual.


Non-Malignant Neoplasm

description: A category that includes benign neoplasms and neoplasms with uncertain malignant potential. The latter are characterized by clinicopathological features that are not benign, including some degree of mild or mild/moderate atypia/dysplasia, but lack overt malignant morphologic characteristics and there is no evidence of metastasis at the time of diagnosis.


Gonadal Thrombosis

description: Formation of a blood clot (thrombus) in the lumen of the vein that carries blood away from the testis or ovary.


name: Gastric carcinoma stage IV without metastases

description: T4,N2,MO (from PDQ)


Therapy-Related Toxicity

description: The finding of bodily harm due to the poisonous effects associated with the action or administration of therapeutic agents.


Stage IIIB Testicular Cancer AJCC v8

description: Stage IIIB includes: (Any pT/TX, N1-3, M0, S2); (Any pT/TX, Any N, M1a, S2). TX: Testicular cancer in which the primary tumor cannot be assessed. N1: Testicular cancer with metastasis with a lymph node mass 2 cm or smaller in greatest dimension and less than or equal to five nodes positive, none larger than 2 cm in greatest dimension. N2: Testicular cancer with metastasis with a lymph node mass larger than 2 cm but not larger than 5 cm in greatest dimension; or more than five nodes positive, none larger than 5 cm; or evidence of extranodal extension of tumor. N3: Testicular cancer with metastasis with a lymph node mass larger than 5 cm in greatest dimension. M0: Testicular cancer without evidence of distant metastasis. M1a: Testicular cancer with non-retroperitoneal nodal or pulmonary metastases. S2: LDH 1.5-10 x N or hCG (mlU/mL) 5,000-50,000 or AFP (ng/mL) 1,000-10,000. N indicates the upper limit of normal for the LDH assay. (AJCC 8th ed.)


Goblet Cell Adenocarcinoma

description: A rare adenocarcinoma that exhibits neuroendocrine differentiation and is associated with the presence of neoplastic signet-ring cells resembling goblet cells of the intestine.


Transplant-Related Carcinoma

description: A carcinoma that arises in a patient with a history of organ transplantation.


Stage IA2 Cervical Cancer AJCC v9

description: Stage IA2 includes: T1a2, N0, M0. T1a2: Tumor with measured stromal invasion of more than 3.0 mm and equal or less than 5.0 mm in depth. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Duodenal fistula

description: An abnormal communication between the duodenum and another organ or cavity.


Stage I Gallbladder Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or muscular layer. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.)


Recurrent Hematologic Malignancy

description: The reemergence of a hematologic malignancy after a period of remission.


Stage II Adult Hodgkin Lymphoma

description: Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).


Hemoglobin Lepore Syndrome

description: A beta thalassemia resulting from an unequal crossover/recombination event involving portions of the delta and beta globin genes, resulting in underproduction of the abnormal delta-beta globin.


name: Unresectable Pancreatic Neuroendocrine Tumor

description: Pancreatic neuroendocrine tumor that is not amenable to surgical resection.


Lupus Flare

description: An exacerbation of the chronic disease lupus.


Palisaded encapsulated neuroma

description: A benign peripheral nerve sheath tumor characterized by the presence of Schwann cells, axons, and perineurial fibroblasts.  It usually arises from the skin of the head and neck or the oral mucosa.  It presents as a solitary and painless nodular mass.


Refractory Meningioma

description: Meningioma that is resistant to treatment.


name: Mental and Behavioral Signs and Symptoms

description: Clinical evidence of disease resulting from mental and/or behavioral dysfunction.


Staphylococcal enterocolitis

description: Gastroenteritis resulting from an infection with Staphylococcus aureus.


Advanced Carcinoma

description: Carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage II Cervical Cancer AJCC v9

description: Stage II includes: T2, N0, M0. T2: Tumor invading beyond the uterus but not to the pelvic wall or to lower third of vagina. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


name: Pathologic Stage IIIC Cutaneous Melanoma AJCC v8

description: Stage IIIC includes: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration.  N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


name: Localized Non-Muscle Invasive Bladder Urothelial Carcinoma

description: A bladder urothelial carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites, and has not invaded the bladder muscularis propria.


name: Epithelioid Hemangioendothelioma with YAP1-TFE3 Gene Fusion

description: Epithelioid hemangioendothelioma characterized by a YAP1-TFE3 gene fusion. This gene fusion occurs in a subset of epithelioid hemangioendotheliomas characterized by the presence of well-formed vessels lined by epithelioid endothelial cells with abundant eosinophilic cytoplasm. Patients with YAP1-TFE3 gene fusion tumors tend to be younger than those with a WWTR1-CAMTA1 gene fusion.


name: Neoantigen-Positive Malignant Solid Neoplasm

description: A malignant solid neoplasm characterized by the expression of antigens resulting from cancer-specific mutations (neoantigens).


name: Lugano Classification Stage IIE Adult Hodgkin Lymphoma AJCC v8

description: Stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm. (from AJCC 8th Ed.)


name: Femoral Hernia with Obstruction without Mention of Gangrene

description: The protrusion of contents of the abdominal cavity, into the femoral canal, which results in obstruction of intestinal peristalsis, with no mention of necrosis of the herniated contents.


Refractory Ependymoma

description: Ependymoma that does not respond to treatment.


Bodily Pain

description: The sensation of acute or chronic suffering in a body region.


Stage II Osteosarcoma AJCC v7

description: Stage II includes: IIA (T1, N0, M0, G3, G4); IIB (T2, N0, M0, G3, G4).  T1: Tumor 8 cm or less in greatest dimension.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Metastatic Malignant Neoplasm in the Genitourinary System

description: The spread of a malignant neoplasm to the genitourinary system from an adjacent or distant anatomic site.


name: CRP Level Greater than or Equal to 3 mg/L

description: A laboratory test result indicating that C-reactive protein is present in a sample at concentrations of 3 mg/L or more.


Disruptive mood dysregulation disorder

description: A condition in which children or adolescents experience irritability, anger, and intense temper outbursts. The episodes may be frequent and may eventually impact functioning at school, at home or with peers.


Mild Cardiac Valve Regurgitation

description: Evidence of mild retrograde blood flow through the valve(s) of the heart. (ACC)


Domestic Accident

description: An accident taking place within a home.


name: Benign Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm

description: A trichoblastoma characterized by the presence of neoplastic epithelial cells forming cribriform patterns.


Stage IV Vulvar Cancer AJCC v7

description: Stage IV includes: IVA: (T1/T2, N3, M0); (T3, Any N, M0); IVB: (Any T, Any N, M1).  T1: Invasive vulvar cancer confined to the vulva or perineum.  T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement).  T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.  N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis.  M1: distant metastasis (including pelvic lymph node metastasis).  (AJCC 7th ed.)


name: Stage IV Anal Canal Cancer AJCC v6 and v7

description: Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th and 7th Eds.)


name: Radiating Chest Pain Along Left Upper Sternal Border

description: The location of the radiating chest pain is along the left upper sternal border.


name: Acute Myeloid Leukemia with t(3;8)(q26.2;q24); MYC, MECOM

description: An acute myeloid leukemia associated with t(3;8)(q26.2;q24) resulting in MYC and MECOM rearrangement.


name: Hematologic Neoplasm with Germline Predisposition without a Constitutional Disorder Affecting Multiple Organ Systems

description: Familial hematologic neoplasms associated with germline mutations without a preexisting disorder or organ dysfunction.


Chronic pulmonary aspergillosis

description: A spectrum of disorders associated with long-term Aspergillus infection of the lung that usually occur in immunocompetent individuals with underlying respiratory disorders, and may be characterized by pulmonary fibrosis or cavitation.


name: Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma

description: Extrapulmonary small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


name: Unresectable Digestive System Adenocarcinoma

description: An adenocarcinoma that arises from the gastrointestinal system and is not amenable to surgical resection.


Acquired kyphosis

description: Kyphosis, the cause of which is not present at birth.


Cardiovascular Radiation Injury

description: Radiation injury of the cardiovascular system.


name: COVID-19-Associated Nervous System Disorder

description: A central or peripheral nervous system disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).


name: Coronary Artery Ectasia Related to COVID-19

description: Coronary artery ectasia in a patient with probable or confirmed acute COVID-19.


Childhood Pleomorphic Xanthoastrocytoma

description: A pleomorphic xanthoastrocytoma that occurs during childhood.


name: Congenital abnormality of respiratory system

description: An abnormality of the respiratory system that is present at birth or detected in the neonatal period.


Bleeding on Probing

description: Bleeding that is induced by gentle manipulation of the gingival tissue at the depth of the gingival sulcus.


Stage III Esophageal Cancer AJCC v7

description: Stage III includes: For squamous cell carcinoma: IIIA (T1-2, N2, M0, Any G, Tumor location: Any); (T3, N1, M0, Any G, Tumor location: Any); (T4a, N0, M0, Any G, Tumor location: Any); IIIB (T3, N2, M0, Any G, Tumor location: Any); IIIC (T4a, N1-2, M0, Any G, Tumor location: Any); (T4b, Any N, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any).  For adenocarcinoma: IIIA (T1-2, N2, M0, Any G); (T3, N1, M0, Any G); (T4a, N0, M0, Any G); IIIB (T3, N2, M0, Any G); IIIC (T4a, N1-2, M0, Any G); (T4b, Any N, M0, Any G); (Any T, N3, M0, Any G).  T1: Tumor invades lamina propria, muscularis mucosae, or submucosa.  T2: Tumor invades muscularis propria. T3: Tumor invades adventitia. T4a: Resectable tumor invading pleura, pericardium, or diaphragm. T4b: Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. N0: No regional lymph node metastasis.  N1: Metastasis in 1-2 regional lymph nodes.  N2: Metastasis in 3-6 regional lymph nodes.  N3: Metastasis in seven or more regional lymph nodes.  M0: No distant metastasis.  Tumor location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.  (AJCC 7th ed.)


Epididymal Papillary Cystadenoma

description: A cystadenoma that arises from the epididymis. It is characterized by the presence of small papillary projections in the inner surface of the cysts. It may be sporadic or associated with von Hippel-Lindau disease.


Advanced Basal Cell Carcinoma

description: Basal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IIB Bone Sarcoma AJCC v7

description: Stage IIB includes: T2, N0, M0, G3, G4.  T2: Tumor more than 8 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  G3: Poorly differentiated.  G4: Undifferentiated. (AJCC 7th ed.)


name: Pathologic Stage IIA Cutaneous Melanoma AJCC v8

description: Stage IIA includes: (T2b, N0, M0); (T3a, N0, M0). T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable. (AJCC 8th ed.)


Acquired Phrenic Nerve Palsy

description: Damage to the phrenic nerve that results in paralysis of the hemidiaphragm and was not present at birth.


name: Circumscribed Meningeal Melanocytic Neoplasm

description: A circumscribed neoplasm that arises from leptomeningeal melanocytes. This category includes meningeal melanocytoma and meningeal melanoma.


Mycosis fungoides (Working Formulation)

description: A peripheral (mature) T-cell lymphoma presenting in the skin with patches/plaques and it is characterized by epidermal and dermal infiltration of small to medium-sized T-cells with cerebriform nuclei.  Patients with limited disease generally have an excellent prognosis.  In the more advanced stages, the prognosis is poor. (WHO, 2001)


First degree uterine prolapse

description: The uterus has descended above the hymen.


Stage III Uterine Corpus Cancer AJCC v6

description: Stage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Local and/or regional spread as defined below.  T3a: Tumor invades serosa and/or adnexa (direct extension or metastasis) and/or cancer cells in ascites or peritoneal washings.  T3b Vaginal involvement (direct extension or metastasis). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis to pelvic and/or para-aortic nodes.  M0: No distant metastasis. (AJCC 6th ed.)


name: Stage M1 Childhood Ependymoma by Toronto Guidelines v2

description: Tumor cells in the CSF. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)


name: Human Papillomavirus-Independent Vaginal Squamous Cell Carcinoma

description: Vaginal squamous cell carcinoma not associated with human papillomavirus infection.


Stage IIA Cervical Cancer AJCC v9

description: Stage IIA includes: T2a, N0, M0. T2a: Tumor with involvement limited to the upper two-thirds of the vagina without parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (from AJCC 9th Ed.)


Post-streptococcal reactive arthritis

description: The occurrence of arthritis after infection with group A streptococcus. It is non-migratory, protracted in course, and poorly responsive to anti-inflammatory agents. (from Textbook of Pediatric Rheumatology, 6th ed. Cassidy, Petty, Laxer, and Lindsley)


name: Refractory Female Reproductive System Carcinoma

description: Female reproductive system carcinoma that is resistant to treatment.


name: Low Grade Corneal Squamous Intraepithelial Neoplasia

description: A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the corneal epithelium.


name: Intraductal papillary neoplasm with high grade intraepithelial neoplasia

description: An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of severe epithelial atypia.


Nuclear Cataract Grade 3

description: A stage of nuclear sclerotic cataract marked by pronounced yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


name: Platinum-Sensitive Fallopian Tube Carcinoma

description: Fallopian tube carcinoma that has a documented response to platinum-based chemotherapy.


Gastric mucositis

description: An inflammatory process affecting the mucous membrane of the stomach.


name: Stage IVA Cervical Cancer AJCC v6 and v7

description: Stage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)


Benign neoplasm of lacrimal apparatus

description: A neoplasm that arises from the lacrimal gland or lacrimal drainage system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.


name: FIGO Stage IIC Gestational Trophoblastic Tumor


Hyalinizing Clear Cell Carcinoma

description: A rare, slow-growing carcinoma characterized by the presence of malignant clear and eosinophilic cells in a hyalinized stroma. It has been described in the salivary glands and lung. Most cases are associated with translocation of EWSR1 and ATF1, resulting in the formation of EWSR1-ATF1 fusion gene. The prognosis is good.


Lumbar myelocele

description: Herniation of spinal cord tissue and meninges through a defect in the lumbar region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.


name: Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma

description: Bladder clear cell (glycogen-rich) urothelial carcinoma that has spread to another anatomic site.


name: Myelodysplastic Syndrome, Unclassifiable, with Defining Cytogenetic Abnormality

description: Myelodysplastic syndrome, unclassifiable characterized by persistent cytopenia (s) with 1 percent or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10 percent of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome.


Achromic nevus

description: A benign nevus characterized by the absence of melanin pigment in the melanocytes.


Papillary neoplasm

description: A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures.


name: Childhood Langerhans Cell Histiocytosis without Risk Organ Involvement

description: Langerhans cell histiocytosis that occurs during childhood and does not involve the bone marrow, spleen, liver, or lung.


Esophageal adenocarcinoma stage IV

description: An adenocarcinoma that arises from the esophagus and has metastasized to another anatomic site.


Destructive Arthritis

description: Arthritis associated with the destruction of the cartilage and the articular surface of the bone of the joint. This process severely interferes with movement in the joint.


Lymphoma by Ann Arbor Stage

description: An anatomic stage for Hodgkin and non-Hodgkin lymphomas  based on the Ann Arbor classification criteria.


Bilateral glaucoma

description: Increased pressure in both eyeballs due to obstruction of the outflow of aqueous humor.


name: Chest Pain Along Left Midclavicular Line

description: The location of the chest pain is along the left midclavicular line.


Recurrent Childhood Malignant Neoplasm

description: The reemergence of a childhood malignant neoplasm after a period of remission.


name: Locally Advanced Malignant Female Reproductive System Neoplasm

description: A malignant female reproductive system neoplasm that has spread from its original site of growth to nearby tissues or lymph nodes.


Intercalated Duct Hyperplasia

description: A salivary ductal proliferation resembling intercalated ducts. (WHO 2017)


Childhood Diabetes Mellitus

description: Diabetes mellitus that develops during childhood.


name: Precursor T-lymphoblastic lymphoma/leukemia recurrent

description: The reemergence of T-lymphoblastic leukemia/lymphoma after a period of remission.


Vaginal Undifferentiated Carcinoma

description: A carcinoma that arises from the vagina and is characterized by the lack of specific cellular differentiation.


name: DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 5

description: Dyskeratosis congenita caused by mutation(s) in the RTEL1 gene, encoding regulator of telomere elongation helicase 1.


name: Musculoskeletal Chest Pain due to Costochondritis

description: A condition in which there is musculoskeletal chest pain associated with inflammation of one or more ribs and/or cartilages. (ACC/AHA)


name: Stage III Gestational Trophoblastic Neoplasm AJCC v8

description: Stage III includes: Any T, M1a. M1a: Gestational trophoblastic neoplasm with lung metastasis. (AJCC 8th Ed.)


name: Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8

description: Stage IV includes: IVA: (T4a, N2, M0, Any G); (T4b, N0-2, M0, Any G); (Any T, N3, M0, Any G); IVB: (Any T, Any N, M1, Any G). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.)


name: Cutaneous Mature T-Cell and NK-Cell Neoplasm

description: A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells affecting the skin.


Refractory Adenocarcinoma

description: An adenocarcinoma that does not respond to treatment.


EBV-Related Hodgkin Lymphoma

description: Hodgkin lymphoma that is caused by Epstein-Barr virus infection.


name: High Grade Pancreatic Intraepithelial Neoplasia

description: A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis.  Severe dysplasia is present.


Neuroendocrine carcinoma of appendix

description: An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the appendix. The mitotic count is more than 20 per 10 HPF. It is classified as either small or large cell neuroendocrine carcinoma based on the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm.


Hindgut Neuroendocrine Tumor G3

description: A neuroendocrine tumor grade 3 that arises from the sigmoid colon, descending colon, or rectum.


name: Locally Advanced Neuroendocrine Carcinoma

description: A neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Remote Placental Infarction

description: A focus of necrotic placental parenchyma with marked hyalinization and fibrosis with complete absence of the necrotic chorionic villi, which is frequently more than 7 days of duration.


name: Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8

description: Stage IIA includes: (T2, N0, M0, G3); (T2, N0, M0, GX). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated. (AJCC 8th ed.)


Stage IIIB Bladder Cancer AJCC v8

description: Stage IIIB includes: T1-T4a, N2, N3, M0. T1: Tumor invades lamina propria (subepithelial connective tissue). T2: Tumor invades muscularis propria. T3: Tumor invades perivesical soft tissue. T4a: Extravesical tumor invades directly into prostatic stroma, uterus, vagina. N2: Multiple regional lymph node metastasis in the true pelvis (perivesical, obturator, internal and external iliac, or sacral lymph node metastasis). N3: Lymph node metastasis to the common iliac lymph nodes. M0: No distant metastasis. (AJCC 8th ed.)


Acquired methemoglobinemia

description: Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods.


Stage I Fallopian Tube Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage I Vulvar Cancer AJCC v8

description: Stage I includes: T1, N0, M0. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th Ed.)


Stage IV Bladder Cancer AJCC v8

description: Stage IV includes: IVA: (T4b, N0, M0); (Any T, Any N, M1a); IVB: (Any T, Any N, M1b). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs. M1b: Non-lymph node distant metastases. (AJCC 8th ed.)


Sharp Pain

description: A sensation of discomfort or distress that is distinct and intensely focused.


name: Helicobacter Pylori-Related Gastric Adenocarcinoma

description: An adenocarcinoma that arises from the gastric mucosa and is caused by persistent infection with Helicobacter pylori.


name: Locally Advanced Transitional Cell Carcinoma

description: Transitional cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.


Chemical esophagitis

description: Esophagitis secondary to chemical exposure.


name: Endocrine disorder arising from mental factors

description: An endocrine disorder that is caused by abnormal mental function.


Recurrent Childhood Oligodendroglioma

description: The reemergence of oligodendroglioma in childhood after a period of remission.


Familial Testicular Germ Cell Tumor

description: Germ cell tumor that arises from the testis and is diagnosed in at least two relatives.


name: Stage II Adult Diffuse Small Cleaved Cell Lymphoma

description: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)


Congenital hamartoma

description: A hamartomatous lesion which is present at birth.


Immune System and Related Disorders

description: A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation).


name: Cervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma

description: A carcinoma that arises from the cervix and is characterized by the presence of a cervical adenocarcinoma variant and a neuroendocrine carcinoma component.


Phrenic Nerve Palsy Related to Birth

description: A condition characterized by reduced or absent movement of the ipsilateral diaphragm as a consequence of an injury to the phrenic nerve or its origin in cervical roots 3 through 5 sustained during the birthing process.


name: Metastatic Malignant Neoplasm in the Visual Pathway

description: A malignant neoplasm that has spread to the visual pathway from another anatomic site.


Advanced Ampulla of Vater Carcinoma

description: Carcinoma that arises from the ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment.


Stage IVA Bladder Cancer

description: Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis.


name: Moderately Differentiated Malignant Neoplasm

description: A neoplasm whose histologic characteristics are intermediate between poorly differentiated and well differentiated.


Refractory Urothelial Carcinoma

description: Urothelial carcinoma that does not respond to treatment.


Nuclear Cataract Grade 1

description: A stage of nuclear sclerotic cataract marked by mild yellowing and sclerosis of the lens nucleus. (Modified LOCS II)


Adult Rhabdomyosarcoma

description: An aggressive malignant mesenchymal neoplasm arising from skeletal muscle in adults.


Paratesticular Endometrioid Tumor

description: A group of very rare tumors with endometrioid epithelial differentiation arising from the paratesticular structures. It includes benign tumors, borderline tumors (tumors with atypical epithelial proliferation), and malignant tumors (endometrioid adenocarcinomas).