icosanoid secretion

description: The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.


sister chromatid segregation

category: biolink:BiologicalProcess biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.


metanephric collecting duct development

description: The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder.


emtricitabine

An organofluorine compound  that is 5-fluorocytosine substituted at the 1 position by a 2-(hydroxymethyl)-1,3-oxathiolan-5-yl group (2R,5S configuration). It is used in combination therapy for the treatment of HIV-1 infection.


name: regulation of actin filament polymerization

description: Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.


Oligomenorrhea

category: biolink:PhenotypicFeature biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: Infrequent menses (less than 6 per year or more than 35 days between cycles).


name: negative regulation of protein-containing complex disassembly

description: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.


tolbutamide

An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.


hepatic porphyria

category: biolink:Disease biolink:DiseaseOrPhenotypicFeature biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing

description: A group of metabolic diseases due to deficiency of one of a number of liver enzymes in the biosynthetic pathway of heme. They are characterized by the accumulation and increased excretion of porphyrins or its precursors. Clinical features include neurological symptoms (porphyria, acute intermittent), cutaneous lesions due to photosensitivity (porphyria cutanea tarda), or both (hereditary coproporphyria). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.


glycosphingolipid biosynthetic process

description: The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.


allergic contact dermatitis

description: An inflammatory skin condition caused by an immune response to direct contact between the skin and an allergen. It consists of a delayed type of allergic reaction at the affected site with resulting red, swollen, and blistered skin that may itch or leak.


name: translation factor activity, RNA binding

category: biolink:MolecularActivity biolink:Occurrent biolink:OntologyClass biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.


cytoplasmic side of membrane

category: biolink:CellularComponent biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The side of a membrane that faces the cytoplasm.


name: Cushing disease due to pituitary adenoma

description: Cushing's syndrome due to abnormally high secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland.


protein targeting to mitochondrion

description: The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.


name: regulation of G1/S transition of mitotic cell cycle

description: Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


asymmetric cell division

description: The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.


desvenlafaxine

A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.


response to fungus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.


name: tRNA (cytidine) methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.


calcium ion transmembrane transport

description: A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


regulation of muscle hypertrophy

description: Any process that modulates the frequency, rate or extent of muscle hypertrophy.


extraembryonic membrane development

description: The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure.


Vaginal pruritus

description: A sensation of itching in the vagina.


positive regulation of gluconeogenesis

description: Any process that activates or increases the frequency, rate or extent of gluconeogenesis.


snRNA 3'-end processing

description: Any process involved in forming the mature 3' end of an snRNA molecule.


cellular response to virus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


name: positive regulation of hematopoietic progenitor cell differentiation

description: Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.


dihydroergotamine

Ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension.


name: chemical synaptic transmission, postsynaptic

category: biolink:Pathway biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.


name: regulation of myeloid leukocyte differentiation

description: Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.


Decreased body mass index

description: Abnormally decreased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of underweight compared to averages.


histone methyltransferase activity

description: Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue.


vein disorder

description: A disease involving the vein.


Altered state of consciousness

category: biolink:Behavior biolink:OntologyClass biolink:ActivityAndBehavior biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: NAD-dependent histone H3K14 deacetylase activity

description: Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.


aminoacyl-tRNA hydrolase activity

description: Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.


cardiac muscle cell fate commitment

description: The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.


name: folic acid-containing compound metabolic process

description: The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.


ochronosis disorder

description: A disorder characterized by bluish-black discoloration of the cartilaginous tissues due to accumulation of homogentisic acid. It is associated with alkaptonuria. Signs and symptoms include dark urine, skin pigmentation, and arthritis.


ubiquitin-like protein binding

description: Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.


tumor necrosis factor receptor activity

description: Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.


dendritic spine organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.


deoxyribose phosphate metabolic process

description: The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose.


collagen V binding

description: Binding to a type V collagen trimer.


peritoneum cancer

description: A malignant neoplasm involving the peritoneum


name: regulation of ubiquitin-dependent protein catabolic process

description: Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process.


mismatch repair

description: A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.


dopamine receptor binding

description: Binding to a dopamine receptor.


hydralazine

The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.


ribonuclease III activity

description: Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.


name: cellular response to purine-containing compound

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.


cutaneous vasculitis

description: Inflammation of the blood vessel wall characterized by palpable purpura.


name: glutamine family amino acid catabolic process

description: The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.


integrin binding

description: Binding to an integrin.


detection of bacterium

description: The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.


Tearing

description: Shedding of tears.


vision disorder

description: Any impairment to the vision.


glycine transport

description: The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


description: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.


chemokine-mediated signaling pathway

description: The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


cellular response to radiation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.


name: MyD88-independent toll-like receptor signaling pathway

description: A toll-like receptor signaling pathway not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate an immune response.


coumarin catabolic process

description: The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids.


cellular response to cAMP

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.


name: positive regulation of fibroblast migration

description: Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.


name: positive regulation of dendritic spine development

description: Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


gastrulation

description: A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.


coated membrane

description: A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes.


adenosine deaminase activity

description: Catalysis of the reaction: adenosine + H2O = inosine + NH3.


Anejaculation

description: Inability to ejaculate.


induction of bacterial agglutination

description: Any process in which infecting bacteria are clumped together by a host organism.


positive regulation of TORC1 signaling

description: Any process that activates or increases the frequency, rate or extent of TORC1 signaling.


clathrin-dependent endocytosis

description: An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.


Hernia

description: The protrusion of part of an organ or fibroadipose tissue through an abnormal opening.


nuclear receptor activity

description: A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.


cefditoren

A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.


name: regulation of postsynaptic membrane potential

description: Any process that modulates the potential difference across a post-synaptic membrane.


cellular response to ionizing radiation

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.


description: Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.


folic acid receptor activity

description: Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis.


tetrahydrofolate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.


androgen receptor signaling pathway

description: A nuclear receptor-mediated signaling pathway initiated by an androgen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.


cortical cytoskeleton

description: The portion of the cytoskeleton that lies just beneath the plasma membrane.


adrenergic receptor signaling pathway

description: A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


regulation of epithelial cell migration

description: Any process that modulates the frequency, rate or extent of epithelial cell migration.


name: phospholipase C-activating G protein-coupled receptor signaling pathway

description: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).


Papule

description: A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point.


name: epidermal growth factor receptor binding

description: Binding to an epidermal growth factor receptor.


name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

description: The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules.


cellular response to oxygen levels

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


polyol biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms.


Muscle fibrillation

description: Fine, rapid twitching of individual muscle fibers with little or no movement of the muscle as a whole. If a motor neuron or its axon is destroyed, the muscle fibers it innervates undergo denervation atrophy. This leads to hypersensitivity of individual muscle fibers to acetyl choline so that they may contract spontaneously. Isolated activity of individual muscle fibers is generally so fine it cannot be seen through the intact skin, although it can be recorded as a short-duration spike in the EMG.


name: double-strand break repair via classical nonhomologous end joining

description: An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining).


name: P-type potassium:proton transporter activity

description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).


circadian regulation of gene expression

description: Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.


regulation of mRNA metabolic process

description: Any process that modulates the frequency, rate or extent of mRNA metabolic process.


taurine metabolic process

description: The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.


name: regulation of androgen receptor signaling pathway

description: Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.


name: negative regulation of adherens junction organization

description: Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization.


name: negative regulation of isotype switching to IgE isotypes

description: Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes.


name: positive regulation of ubiquitin protein ligase activity

description: Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity.


Respiratory alkalosis

description: Alkalosis due to excess loss of carbon dioxide from the body.


tonsillitis

description: Inflammation of the tonsillar tissue.


name: thiamine-containing compound metabolic process

description: The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.


Recurrent fractures

description: The repeated occurrence of bone fractures (implying an abnormally increased tendency for fracture).


Trismus

description: Limitation in the ability to open the mouth.


regulation of microtubule nucleation

description: Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


chemokine activity

description: The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


response to virus

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


aminoacyl-tRNA editing activity

description: The hydrolysis of an incorrectly aminoacylated tRNA.


name: phosphatidylinositol phosphate biosynthetic process

description: The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.


steroid hydroxylase activity

description: Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.


name: cellular detoxification of nitrogen compound

description: Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.


cerebral cortex cell migration

description: The orderly movement of cells from one site to another in the cerebral cortex.


hydrarthrosis

description: Accumulation of watery fluid in the cavity of a joint. (Dorland, 27th ed)


transport of virus

description: The directed movement of a virus, or part of a virus, into, out of, or within a host cell.


neural precursor cell proliferation

description: The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.


neural crest cell development

description: The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.


AMP biosynthetic process

description: The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.


fructose metabolic process

description: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.


phosphatase inhibitor activity

description: Binds to and stops, prevents or reduces the activity of a phosphatase.


name: positive regulation of blood vessel endothelial cell migration

description: Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.


regulation of amine transport

description: Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


bromodiphenhydramine

A  tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.


Sinus tachycardia

description: Heart rate of greater than 100 beats per minute.


name: B cell activation involved in immune response

description: The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


Lymphadenopathy

description: Enlargment (swelling) of a lymph node.


labetalol

A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.


Ocular hypertension

description: Intraocular pressure that is 2 standard deviations above the population mean.


name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

description: Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.


regulation of steroid hormone secretion

description: Any process that modulates the frequency, rate or extent of steroid hormone secretion.


name: regulation of catecholamine uptake involved in synaptic transmission

description: Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell.


vesicle transport along microtubule

description: The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.


positive regulation of saliva secretion

description: Any process that activates or increases the frequency, rate or extent of the regulated release of saliva.


regulation of cell-matrix adhesion

description: Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.


regulation of behavior

description: Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.


bismuth subsalicylate

A bismuth salt of salicylic acid.


gamma-catenin binding

description: Binding to catenin complex gamma subunit.


name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

description: The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.


name: actin polymerization or depolymerization

description: Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.


response to mineralocorticoid

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance.


name: positive regulation of nuclease activity

description: Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.


name: phenol-containing compound biosynthetic process

description: The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.


congenital generalized lipodystrophy

description: An extremely rare autosomal recessive condition, characterized by an extreme scarcity of fat in the subcutaneous tissues.


name: organic acid transmembrane transporter activity

description: Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage.


gastroparesis

description: Paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine.


cerebellar cortex development

description: The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


name: negative regulation of steroid biosynthetic process

description: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.


Tongue edema

description: An abnormal accumulation of fluid and swelling in the tongue.


name: miRNA-mediated gene silencing by inhibition of translation

description: An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.


reciprocal meiotic recombination

description: The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.


DNA repair complex

description: A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.


METHYSERGIDE

A synthetic ergot alkaloid, structurally related to the oxytocic agent methylergonovine and to the potent hallucinogen LSD and used prophylactically to reduce the frequency and intensity of severe vascular headaches.


name: positive regulation of immunoglobulin production

description: Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.


name: regulation of endodermal cell differentiation

description: Any process that modulates the frequency, rate or extent of endodermal cell differentiation.


mast cell degranulation

description: The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.


maintenance of cell number

description: Any process by which the numbers of cells of a particular type or in a tissue are maintained.


photoreceptor cell development

description: Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.


DNA integrity checkpoint signaling

description: A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.


name: negative regulation of neuron projection development

description: Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


perinuclear endoplasmic reticulum

description: The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.


phosphatase regulator activity

description: Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.


regulation of ATP-dependent activity

description: Any process that modulates the rate of an ATP-dependent activity.


name: positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

description: Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.


nuclear estrogen receptor binding

description: Binding to a nuclear estrogen receptor.


Gamma-Glutamyltransferase Increased

description: Increase in the level of the enzyme gamma-glutamyltransferase in the blood, which catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, aminoacids, or water.


peptide cross-linking

description: The formation of a covalent cross-link between or within protein chains.


name: negative regulation of post-transcriptional gene silencing

description: Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism.


regulation of reproductive process

description: Any process that modulates the frequency, rate or extent of reproductive process.


apraclonidine

An imidazoline that is 2-amino 4,5-dihydro-1H-imidazoline in which one of the exocyclic amino hydrogens has been replaced by a 4-amino-2,6-dichlorophenyl group.


cellular metabolic compound salvage

description: Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells.


name: nuclear thyroid hormone receptor binding

description: Binding to a nuclear thyroid hormone receptor.


name: negative regulation of microtubule depolymerization

description: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.


cobalamin metabolic process

description: The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.


cilium assembly

description: The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.


Deviated nasal septum

description: Positioning of the nasal septum to the right or left in contrast to the normal midline position of the nasal septum.


name: negative regulation of proteolysis involved in protein catabolic process

description: Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process.


bepridil

A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.


name: regulation of angiotensin metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin.


sulfadimethoxine

A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.


specification of symmetry

description: The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.


ANIDULAFUNGIN

A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.


symporter activity

description: Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.


detection of calcium ion

description: The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.


carboplatin

A platinum coordination entity with cis square-planar geometry in which  platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.


constrictive pericarditis

description: A heart disorder in which the pericardial sac becomes thickened and fibrotic, tightening the myocardium and impeding the normal myocardial function.


omega peptidase activity

description: Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes.


age-related macular degeneration

description: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.


Hemorrhage of the eye

description: Bleeding from vessels of the various tissues of the eye.


apicolateral plasma membrane

description: The apical end of the lateral plasma membrane of epithelial cells.


sex differentiation

description: The establishment of the sex of an organism by physical differentiation.


sunburn

description: An inflammatory reaction from ultraviolet radiation characterized by transient redness, tenderness and occasional blistering.


corneal epithelium

category: biolink:GrossAnatomicalStructure biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The smooth stratified squamous epithelium that covers the outer surface of the cornea.


depersonalization disorder

description: A disorder characterized by persistent or recurrent episodes of feeling detached from one's self (either one's body or one's mental processes), although the sufferer remains aware that this is only a feeling and does not represent reality.


post-embryonic eye morphogenesis

description: The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight.


sarcolemma

description: The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.


name: negative regulation of viral genome replication

description: Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.


name: retrograde transport, vesicle recycling within Golgi

description: The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.


ATP-gated ion channel activity

description: Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.


name: fatty acid elongation, polyunsaturated fatty acid

description: Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced.


regulation of stress fiber assembly

description: Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.


proteinuria

description: The presence of abnormal amounts of protein in the urine.


sarcomere organization

description: The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


name: negative regulation of thymocyte aggregation

description: Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation.


myotube differentiation

description: The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


retrograde transport, endosome to Golgi

description: The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.


name: positive regulation of protein-containing complex disassembly

description: Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.


thoracic aortic aneurysm

description: An aneurysm formed in the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.


name: positive regulation of synaptic vesicle recycling

description: Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling.


macromolecule methylation

description: The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.


name: regulation of bile acid biosynthetic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


name: regulation of opsin-mediated signaling pathway

description: Any process that modulates the frequency, rate or extent of opsin-mediated signaling.


name: positive regulation of potassium ion transmembrane transporter activity

description: Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity.


name: positive regulation of nitric-oxide synthase activity

description: Any process that activates or increases the activity of the enzyme nitric-oxide synthase.


Fetal Death

description: A fetus of at least 20 weeks gestation, or of a birth weight of at least 350 grams if the gestational age is unknown, that is born without signs of life at the time of delivery, and with an Apgar score of zero at both one and five minutes.


chlordiazepoxide

A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.


clozapine

A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like  schizophrenia.


name: purine nucleoside bisphosphate metabolic process

description: The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar.


Urinary hesitancy

description: Difficulty in beginning the process of urination.


name: positive regulation of actin filament bundle assembly

description: Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.


mRNA 3'-end processing

description: Any process involved in forming the mature 3' end of an mRNA molecule.


gastrulation with mouth forming second

description: A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.


hydroflumethiazide

A benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide.


name: positive regulation of antigen receptor-mediated signaling pathway

description: Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.


peroxisomal transport

description: Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.


serotonin receptor signaling pathway

description: The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.


itraconazole

An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.


name: regulation of small GTPase mediated signal transduction

description: Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.


sensory perception of sound

description: The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.


name: positive regulation of peptide hormone secretion

description: Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


negative chemotaxis

description: The directed movement of a motile cell or organism towards a lower concentration of a chemical.


polyol catabolic process

description: The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms.


embryonic axis specification

description: The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.


histone binding

description: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.


chlorzoxazone

A member of the class of  1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.


name: negative regulation of phosphoprotein phosphatase activity

description: Any process that stops or reduces the activity of a phosphoprotein phosphatase.


name: regulation of mitochondrial DNA replication

description: Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.


autophagic cell death

description: A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.


intercalated disc

description: A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.


protein palmitoylation

description: The covalent attachment of a palmitoyl group to a protein.


name: positive regulation of translational initiation in response to stress

description: Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.


erythrocyte maturation

description: A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.


name: myeloid dendritic cell activation involved in immune response

description: The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.


lymphocyte mediated immunity

description: Any process involved in the carrying out of an immune response by a lymphocyte.


Golgi to plasma membrane transport

description: The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.


name: regulation of phospholipid metabolic process

description: Any process that modulates the frequency, rate or extent of phospholipid metabolic process.


hepatic encephalopathy

description: Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.Signs and symptomsmay be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may includepersonality or moodchanges, intellectual impairment, abnormal movements,a depressed level of consciousness, and other symptoms.There are several theories regarding the exact cause, butdevelopment of the condition isprobablyat least partiallydue to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis.


Ino80 complex

description: A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.


large ribosomal subunit

description: The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).


DBIRD complex

description: A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD.


name: negative regulation of cyclin-dependent protein kinase activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity.


name: preassembly of GPI anchor in ER membrane

description: The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane.


nuclear stress granule

description: A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.


calcium-dependent cell-matrix adhesion

description: The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction.


IgG binding

description: Binding to an immunoglobulin of an IgG isotype.


condensed nuclear chromosome

description: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.


tRNA dihydrouridine synthesis

description: The process whereby a uridine in a transfer RNA is converted to dihydrouridine.


leg

description: The portion of the hindlimb that contains both the stylopod and zeugopod.


name: negative regulation of lymphocyte proliferation

description: Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.


Acute abdomen

description: A sudden onset of abdominal pain with associated nausea or vomiting. The acute abdomen may be caused by an infection, inflammation, vascular occlusion, or obstruction.


name: regulation of synaptic transmission, GABAergic

description: Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).


carnitine transport

description: The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.


heart process

description: A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.


paraspeckles

description: Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.


DNA helicase activity

description: Unwinding of a DNA helix, driven by ATP hydrolysis.


mannosyltransferase complex

description: A complex that possesses mannosyltransferase activity.


regulation of catecholamine secretion

description: Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.


Decreased cardiac output

description: A decreased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat.


name: transmitter-gated monoatomic ion channel activity

description: Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.


name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine

description: The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids.


embryonic camera-type eye morphogenesis

description: The process in which the anatomical structures of the eye are generated and organized during embryonic development.


mononuclear cell proliferation

description: The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.


ventricular septum development

description: The progression of the ventricular septum over time from its formation to the mature structure.


description: Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid.


regulation of receptor recycling

description: Any process that modulates the frequency, rate, or extent of receptor recycling.


tight junction

description: A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


pentobarbitone

A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.


name: DNA-directed 5'-3' RNA polymerase activity

description: Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.


sapropterin

A tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer).


name: regulation of cytokine production involved in inflammatory response

description: Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.


name: positive regulation of tolerance induction

description: Any process that activates or increases the frequency, rate, or extent of tolerance induction.


channel regulator activity

description: Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.


name: macromolecule transmembrane transporter activity

description: Enables the transfer of a macromolecule from one side of a membrane to the other.


name: positive regulation of BMP signaling pathway

description: Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.


acepromazine

A member of the class of  phenothiazines that is 10H-phenothiazine substituted by an acetyl group at position 2 and a 3-(dimethylamino)propyl group at position 10.


name: regulation of peptidyl-threonine phosphorylation

description: Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.


name: regulation of nitric-oxide synthase activity

description: Any process that modulates the activity of the enzyme nitric-oxide synthase.


Bulla

description: A large (greater than 5-10 mm) intraepidermal/subepidermal cavity filled with clear, serosanguineous or cloudy fluid.


name: negative regulation of extrinsic apoptotic signaling pathway

description: Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.


Shock

description: The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.


Schwann cell differentiation

description: The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.


actin filament bundle organization

description: A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


gastrointestinal stromal tumor

description: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal (GI) tract, typically presenting in adults over the age of 40 (mean age 63), and only rarely in children, in various regions of the GI tract, most commonly the stomach or small intestine but also less commonly in the esophagus, appendix, rectum and colon. GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass, blood in stool, and intestinal obstruction. GISTs can also be seen in familial syndromes such as Carney triad and neurofibromatosis type 1.


metanephric epithelium development

description: The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


alanine transport

description: The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


response to defenses of other organism

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of another organism.


name: negative regulation of signaling receptor activity

description: Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.


peptidyl-lysine methylation

description: The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative.


replication fork

description: The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.


name: metanephric part of ureteric bud development

description: The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros.


negative regulation of phagocytosis

description: Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.


Atelectasis

description: Collapse of part of a lung associated with absence of inflation (air) of that part.


mood disorder

description: A cognitive disorder a disturbance in which the person's mood is hypothesized to be the main underlying feature.


quinidine

A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.


optic atrophy

description: A disorder characterized by loss of optic nerve fibers. It may be inherited or acquired. Acquired causes include ischemia, optic nerve neuropathy, glaucoma, trauma, radiation, brain tumors, and multiple sclerosis. It leads to vision disturbances.


collagen trimer

description: A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.


name: smooth muscle contraction involved in micturition

description: The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body.


clemastine

2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.


multivesicular body sorting pathway

description: A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.


azatadine

A benzo[5,6]cyclohepta[1,2-b]pyridine having a 1-methylpiperidin-4-ylidene group at the 11-position.


Chest tightness

description: An unpleasant sensation of tightness or pressure in the chest.


morphogenesis of a branching epithelium

description: The process in which the anatomical structures of a branched epithelium are generated and organized.


name: negative regulation of T-helper cell differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation.


peptidyl-lysine acetylation

description: The acetylation of peptidyl-lysine.


cornea

description: The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.


name: Blood thyroid stimulating hormone increased


symbiont-mediated killing of host cell

description: A process mediated by a symbiont that results in the death of a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


Femoral Neck Fractures

description: Traumatic or pathological injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. Symptoms include pain in the hip or groin, bruising and swelling in and around the hip area. The injured hip is turned outward and the leg appears shorter on that side.


acquired lipodystrophy

description: An instance of lipodystrophy (disease) that is acquired during the lifetime of the individual.


name: regulation of branching involved in mammary gland duct morphogenesis

description: Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis.


description: Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.


GMP metabolic process

description: The chemical reactions and pathways involving GMP, guanosine monophosphate.


histone deacetylase binding

description: Binding to histone deacetylase.


moclobemide

A member of the class of  benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.


neuron recognition

description: The process in which a neuronal cell in a multicellular organism interprets its surroundings.


nephron epithelium morphogenesis

description: The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron.


etomidate

The ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity.


heart looping

description: The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation.


name: positive regulation of presynaptic membrane organization

description: Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization.


name: regulation of T-helper 2 cell cytokine production

description: Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production.


name: antigen processing and presentation of peptide antigen via MHC class II

description: The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.


Sertoli cell proliferation

description: The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.


Golgi-associated vesicle membrane

description: The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.


name: oxidoreductase activity, acting on metal ions

description: Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered.


Focal-onset seizure

description: A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures.


manubrium of sternum

description: The cranial most segment of the sternum. Located ventrally with a quadrangular shape, wider superiorly and narrower inferiorly, it articulates with the clavicles and the first two ribs[MP,WP].


mediator complex

description: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


inner cell mass cellular morphogenesis

description: The morphogenesis of cells in the inner cell mass.


name: endoplasmic reticulum-Golgi intermediate compartment

description: A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.


name: response to platelet-derived growth factor

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.


arthritic joint disease

description: An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.


otolithic part of statoconial membrane

category: biolink:AnatomicalEntity biolink:PhysicalEssence biolink:OrganismalEntity biolink:SubjectOfInvestigation biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent

description: The layer of the statoconial membrane that is composed of otoliths.


name: negative regulation of CREB transcription factor activity

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.


name: arterial endothelial cell differentiation

description: The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.


organellar large ribosomal subunit

description: The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).


name: regulation of mast cell activation involved in immune response

description: Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response.


Urinary incontinence

description: Loss of the ability to control the urinary bladder leading to involuntary urination.


name: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

description: The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number.


kidney disorder

description: A disease involving the kidney.


description: Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.


dystonic disorder

description: A movement disorder characterized by sustained or intermittent muscle contractions, resulting in abnormal movements and/or postures.


name: regulation of axon extension involved in axon guidance

description: Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.


peptide hormone binding

description: Binding to a peptide with hormonal activity in animals.


autoimmune hemolytic anemia

description: Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia.


tRNA methylation

description: The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.


Night sweats

description: Occurrence of excessive sweating during sleep.


name: establishment of epithelial cell polarity

description: The specification and formation of anisotropic intracellular organization of an epithelial cell.


name: cellular response to catecholamine stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.


name: negative regulation of transmembrane transport

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.


cell adhesion molecule binding

description: Binding to a cell adhesion molecule.


trans-Golgi network membrane

description: The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.


urea transmembrane transporter activity

description: Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.


cellular response to leptin stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.


name: positive regulation of myeloid leukocyte differentiation

description: Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.


name: type I transforming growth factor beta receptor binding

description: Binding to a type I transforming growth factor beta receptor.


cytarabine

A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties.


name: regulation of SMAD protein signal transduction

description: Any process that modulates the rate, frequency or extent of SMAD protein signal transduction.


cellular response to fluid shear stress

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.


Lower limb pain

description: An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg.


peptide catabolic process

description: The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.


name: negative regulation of interleukin-10 production

description: Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.


name: nucleobase transmembrane transporter activity

description: Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other.


Eye Injuries

description: Damage to the eye.


EPA

An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.


arginine biosynthetic process

description: The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.


beta-catenin destruction complex

description: A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.


intraciliary transport

description: The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.


sweat gland

description: Any of the coil glands of the skin that secrete sweat.


name: endocardial cushion to mesenchymal transition

description: A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


regulation of renal system process

description: Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system.


miliaria

description: A small (one mm or less) vesicular, papular or pustular monomorphous rash, which is associated with heat, fever or occlusion of sweat glands.


name: negative regulation of platelet activation

description: Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.


cardiac ventricle morphogenesis

description: The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.


name: negative regulation of synaptic transmission, GABAergic

description: Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).


regulation of sulfur metabolic process

description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.


cellulitis

description: Inflammation of the dermis and subcutaneous tissues caused by a bacterial infection. Symptoms include erythema, edema, and pain to the affected area.


name: positive regulation of female receptivity

description: Any process that activates or increases the receptiveness of a female to male advances.


protein peptidyl-prolyl isomerization

description: The modification of a protein by cis-trans isomerization of a proline residue.


fatty acid derivative transport

description: The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cutaneous lupus erythematosus

description: An autoimmune disorder that manifests as different lupus-specific skin disorders; it can occur with systemic lupus erythematosus, or as a singular disease.


symbiont entry into host

description: Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction.


microvillus

description: Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.


negative regulation of lipase activity

description: Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.


anisocoria

description: Unequal pupil size, which may represent a benign physiologic variant or a manifestation of disease. Pathologic anisocoria reflects an abnormality in the musculature of the iris (iris diseases) or in the parasympathetic or sympathetic pathways that innervate the pupil. Physiologic anisocoria refers to an asymmetry of pupil diameter, usually less than 2mm, that is not associated with disease.


external acoustic meatus

description: A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter.


name: regulation of mitotic sister chromatid segregation

description: Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.


synaptic vesicle localization

description: Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location.


response to pH

description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


oncostatin-M receptor binding

description: Binding to an oncostatin-M receptor.


name: regulation of DNA topoisomerase (ATP-hydrolyzing) activity

description: Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity.


cardiovascular disorder

description: A disease involving the cardiovascular system.


nabumetone

A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.


name: negative regulation of osteoclast differentiation

description: Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.


name: cellular response to mechanical stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.


innervation

description: The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.


organellar small ribosomal subunit

description: The smaller of the two subunits of an organellar ribosome.


masseter muscle

description: Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by masseteric nerve branches of the trigeminal nerve (CN V), and attaches to mandible and zygomatic arch.


name: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

description: Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.


internal ear

description: Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation.


neutrophil migration

description: The movement of a neutrophil within or between different tissues and organs of the body.


rough endoplasmic reticulum

description: The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.


Breast Feeding

category: biolink:PhysiologicalProcess biolink:OntologyClass biolink:BiologicalProcess biolink:Occurrent biolink:BiologicalProcessOrActivity biolink:BiologicalEntity biolink:ThingWithTaxon biolink:NamedThing biolink:PhysicalEssenceOrOccurrent


name: regulation of inward rectifier potassium channel activity

description: Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity.


triflupromazine

A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position.


name: positive regulation of mitochondrial membrane potential

description: Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


name: regulation of glycoprotein metabolic process

description: Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.


CoA-transferase activity

description: Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).


Dysesthesia

description: Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.


side of membrane

description: A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface.


dicarboxylic acid transport

description: The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


MAP kinase activity

description: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.


choline metabolic process

description: The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.


orgasm disorder

description: A change in the ability to obtain orgasm or in the quality of the orgasmic sensation.


uterus morphogenesis

description: The process in which anatomical structures of the uterus are generated and organized.


Hyperplasia of the endometrium

description: A proliferation of the endometrial cells resulting in glandular enlargement and budding. The proliferation may or may not be associated with atypia of the endometrial cells. When the hyperplastic changes are excessive, there is formation of complex epithelial structures (complex endometrial hyperplasia).


atopic conjunctivitis

description: Conjunctivitis due to hypersensitivity to various allergens.


thrombophlebitis

description: Inflammation of the veins associated with the presence of a thrombus.


lamellipodium membrane

description: The portion of the plasma membrane surrounding a lamellipodium.


Hyperventilation

description: Hyperventilation refers to an increased pulmonary ventilation rate that is faster than necessary for the exchange of gases. Hyperventilation can result from increased frequency of breathing, an increased tidal volume, or both, and leads to an excess intake of oxygen and the blowing off of carbon dioxide.


ganglioside metabolic process

description: The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.


daunorubicin metabolic process

description: The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.


Numbness

description: A loss of the sensation of feeling in an area of the body.


face development

description: The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.


oxybuprocaine

A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester "caine") used especially in ophthalmology and otolaryngology.


endothelial cell migration

description: The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.


hyperglycemia

description: Abnormally high level of glucose in the blood.


hormone secretion

description: The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.


name: regulation of autophagy of mitochondrion

description: Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process.


Smc5-Smc6 complex

description: A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.


name: regulation of microtubule cytoskeleton organization

description: Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.


name: cellular response to dexamethasone stimulus

description: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.


peroxisome organization

description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.


pulmonary myocardium development

description: The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.


methamphetamine

A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.


amphetamine

A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.


regulation of gastric acid secretion

description: Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.


name: establishment or maintenance of cell polarity

description: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


Cryptococcal meningitis

description: Meningeal inflammation produced by cryptococcus neoformans, an encapsulated yeast that tends to infect individuals with acquired immunodeficiency syndrome and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature headache; nausea; photophobia; focal neurologic deficits; seizures; cranial neuropathies; and hydrocephalus. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)


name: nucleoside diphosphate phosphatase activity

description: Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate.


name: negative regulation of lipid metabolic process

description: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.


name: negative regulation of telomerase activity

description: Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


prostaglandin transport

description: The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


cell body membrane

description: The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections.